SIMILAR PATTERNS OF AMINO ACIDS FOR 4CPZ_G_ZMRG1471_2

List of similar pattern of amino acids derived from ASSAM search

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click link on the last column to view superposed patterns of amino acids in NGL viewer)
(Note that only 3-12 residue patterns can be used for ASSAM searches)
Filter list by:
Hit Macromolecule/
Organism		 Pfam Res. Interface HETATM RMSD Dali Z-score Seq. Identity (%) View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1bpl ALPHA-1,4-GLUCAN-4-G
LUCANOHYDROLASE

(Bacillus
licheniformis) 		PF00128
(Alpha-amylase)
PF09154
(DUF1939) 		3 ARG B 354
ARG B 413
TRP B 411
 None
 1.21A 4cpzG-1bplB:
undetectable		 4cpzG-1bplB:
20.51
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1e43 ALPHA-AMYLASE

(Bacillus
amyloliquefaciens) 		PF00128
(Alpha-amylase)
PF09154
(DUF1939) 		3 ARG A 354
ARG A 413
TRP A 411
 None
 1.12A 4cpzG-1e43A:
undetectable		 4cpzG-1e43A:
21.10
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1f4h BETA-GALACTOSIDASE

(Escherichia
coli) 		PF00703
(Glyco_hydro_2)
PF02836
(Glyco_hydro_2_C)
PF02837
(Glyco_hydro_2_N)
PF02929
(Bgal_small_N)
PF16353
(DUF4981) 		3 ARG A  43
ARG A 310
TRP A 261
 None
 1.32A 4cpzG-1f4hA:
undetectable		 4cpzG-1f4hA:
16.55
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ile ISOLEUCYL-TRNA
SYNTHETASE

(Thermus
thermophilus) 		PF00133
(tRNA-synt_1)
PF08264
(Anticodon_1) 		3 ARG A 510
ARG A 509
TRP A 459
 None
 1.00A 4cpzG-1ileA:
undetectable		 4cpzG-1ileA:
19.02
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ity TRF1

(Homo sapiens) 		PF00249
(Myb_DNA-binding) 		3 ARG A 423
ARG A 380
TRP A 383
 None
 1.41A 4cpzG-1ityA:
undetectable		 4cpzG-1ityA:
10.31
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1mjt NITRIC-OXIDE
SYNTHASE HOMOLOG

(Staphylococcus
aureus) 		PF02898
(NO_synthase) 		3 ARG A  57
ARG A  65
TRP A  68
 None
 1.42A 4cpzG-1mjtA:
undetectable		 4cpzG-1mjtA:
20.67
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1nmb N9 NEURAMINIDASE

(Influenza A
virus) 		PF00064
(Neur) 		3 ARG N 152
ARG N 156
TRP N 178
 None
 0.37A 4cpzG-1nmbN:
53.3		 4cpzG-1nmbN:
30.78
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1o5w AMINE OXIDASE
[FLAVIN-CONTAINING]
A

(Rattus
norvegicus) 		PF01593
(Amino_oxidase) 		3 ARG A 454
ARG A 457
TRP A 472
 None
 1.11A 4cpzG-1o5wA:
undetectable		 4cpzG-1o5wA:
20.65
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1o9j ALDEHYDE
DEHYDROGENASE,
CYTOSOLIC 1

(Elephantulus
edwardii) 		PF00171
(Aldedh) 		3 ARG A  84
ARG A  77
TRP A  76
 None
 1.31A 4cpzG-1o9jA:
undetectable		 4cpzG-1o9jA:
22.28
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1qjs HEMOPEXIN

(Oryctolagus
cuniculus) 		PF00045
(Hemopexin) 		3 ARG A 174
ARG A 257
TRP A 268
 HEM  A 500 (-4.2A)
None
None
 1.37A 4cpzG-1qjsA:
2.2		 4cpzG-1qjsA:
20.04
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1u5l PRION PROTEIN

(Trachemys
scripta) 		PF00377
(Prion) 		3 ARG A 156
ARG A 138
TRP A 150
 None
 1.37A 4cpzG-1u5lA:
undetectable		 4cpzG-1u5lA:
15.67
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ud3 AMYLASE

(Bacillus sp.
KSM-K38) 		PF00128
(Alpha-amylase)
PF09154
(DUF1939) 		3 ARG A 354
ARG A 410
TRP A 408
 None
 1.23A 4cpzG-1ud3A:
undetectable		 4cpzG-1ud3A:
21.47
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1v0z NEURAMINIDASE

(Influenza A
virus) 		PF00064
(Neur) 		3 ARG A 158
ARG A 162
TRP A 185
 None
 0.22A 4cpzG-1v0zA:
53.5		 4cpzG-1v0zA:
29.52
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1vcj NEURAMINIDASE

(Influenza B
virus) 		PF00064
(Neur) 		3 ARG A 150
ARG A 154
TRP A 177
 IBA  A   1 (-3.9A)
IBA  A   1 (-4.1A)
None
 0.38A 4cpzG-1vcjA:
73.4		 4cpzG-1vcjA:
91.52
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1vfg POLY A POLYMERASE

(Aquifex
aeolicus) 		PF01743
(PolyA_pol) 		3 ARG A 213
ARG A 216
TRP A 227
 None
 1.04A 4cpzG-1vfgA:
undetectable		 4cpzG-1vfgA:
21.90
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1vjs ALPHA-AMYLASE

(Bacillus
licheniformis) 		PF00128
(Alpha-amylase)
PF09154
(DUF1939) 		3 ARG A 354
ARG A 413
TRP A 411
 None
 1.17A 4cpzG-1vjsA:
undetectable		 4cpzG-1vjsA:
22.14
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1w9x ALPHA AMYLASE

(Bacillus
halmapalus) 		PF00128
(Alpha-amylase)
PF09154
(DUF1939) 		3 ARG A 359
ARG A 415
TRP A 413
 None
 1.13A 4cpzG-1w9xA:
undetectable		 4cpzG-1w9xA:
20.48
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1xog NEURAMINIDASE

(Influenza A
virus) 		PF00064
(Neur) 		3 ARG A 153
ARG A 157
TRP A 180
 ABW  A1000 (-4.1A)
ABW  A1000 (-4.2A)
None
 0.44A 4cpzG-1xogA:
52.9		 4cpzG-1xogA:
28.16
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2an2 P332G A333S DOUBLE
MUTANT OF NITRIC
OXIDE SYNTHASE FROM
BACILLUS SUBTILIS

(Bacillus
subtilis) 		PF02898
(NO_synthase) 		3 ARG A  57
ARG A  65
TRP A  68
 None
 1.48A 4cpzG-2an2A:
undetectable		 4cpzG-2an2A:
18.39
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2c1d SOXA

(Paracoccus
denitrificans) 		no annotation 3 ARG A  73
ARG A  68
TRP A  65
 None
HEC  A1292 (-3.1A)
None
 0.72A 4cpzG-2c1dA:
undetectable		 4cpzG-2c1dA:
18.12
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2d3l GLUCAN
1,4-ALPHA-MALTOHEXAO
SIDASE

(Bacillus sp.
707) 		PF00128
(Alpha-amylase)
PF09154
(DUF1939) 		3 ARG A 359
ARG A 415
TRP A 413
 None
 1.15A 4cpzG-2d3lA:
undetectable		 4cpzG-2d3lA:
20.39
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2d3y URACIL-DNA
GLYCOSYLASE

(Thermus
thermophilus) 		PF03167
(UDG) 		3 ARG A  41
ARG A  23
TRP A  39
 None
SF4  A 220 ( 4.8A)
None
 1.40A 4cpzG-2d3yA:
undetectable		 4cpzG-2d3yA:
17.48
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2d4z CHLORIDE CHANNEL
PROTEIN

(Torpedo
marmorata) 		no annotation 3 ARG A 598
ARG A 706
TRP A 703
 None
 1.47A 4cpzG-2d4zA:
undetectable		 4cpzG-2d4zA:
19.74
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2die AMYLASE

(Bacillus sp.
(in: Bacteria)) 		PF00128
(Alpha-amylase)
PF09154
(DUF1939) 		3 ARG A 359
ARG A 415
TRP A 413
 None
 0.77A 4cpzG-2dieA:
undetectable		 4cpzG-2dieA:
20.76
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2fx5 LIPASE

(Pseudomonas
mendocina) 		no annotation 3 ARG A 201
ARG A 202
TRP A 251
 None
 1.42A 4cpzG-2fx5A:
undetectable		 4cpzG-2fx5A:
20.90
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2htv NEURAMINIDASE

(Influenza A
virus) 		PF00064
(Neur) 		3 ARG A 152
ARG A 156
TRP A 178
 None
 0.25A 4cpzG-2htvA:
51.3		 4cpzG-2htvA:
31.73
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2pbi REGULATOR OF
G-PROTEIN SIGNALING
9

(Mus musculus) 		PF00610
(DEP)
PF00615
(RGS)
PF00631
(G-gamma) 		3 ARG A 292
ARG A 295
TRP A 296
 None
 1.45A 4cpzG-2pbiA:
undetectable		 4cpzG-2pbiA:
20.60
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2qs8 XAA-PRO DIPEPTIDASE

(Alteromonas
macleodii) 		PF01979
(Amidohydro_1) 		3 ARG A 111
ARG A 367
TRP A 231
 None
 1.40A 4cpzG-2qs8A:
undetectable		 4cpzG-2qs8A:
24.56
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2vd5 DMPK PROTEIN

(Homo sapiens) 		PF00069
(Pkinase) 		3 ARG A 129
ARG A 210
TRP A 130
 None
 1.49A 4cpzG-2vd5A:
undetectable		 4cpzG-2vd5A:
22.15
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2x05 EXO-BETA-D-GLUCOSAMI
NIDASE

(Amycolatopsis
orientalis) 		PF00703
(Glyco_hydro_2)
PF02837
(Glyco_hydro_2_N) 		3 ARG A 335
ARG A 311
TRP A 301
 None
CD  A1904 ( 4.8A)
None
 1.30A 4cpzG-2x05A:
undetectable		 4cpzG-2x05A:
18.17
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3bga BETA-GALACTOSIDASE

(Bacteroides
thetaiotaomicron) 		PF00703
(Glyco_hydro_2)
PF02836
(Glyco_hydro_2_C)
PF02837
(Glyco_hydro_2_N)
PF02929
(Bgal_small_N)
PF16353
(DUF4981) 		3 ARG A 216
ARG A 230
TRP A 217
 None
 1.49A 4cpzG-3bgaA:
undetectable		 4cpzG-3bgaA:
16.24
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3bk5 PUTATIVE OUTER
MEMBRANE
LIPOPROTEIN-SORTING
PROTEIN

(Vibrio
parahaemolyticus) 		PF17131
(LolA_like) 		3 ARG A 163
ARG A  13
TRP A 193
 None
 1.36A 4cpzG-3bk5A:
undetectable		 4cpzG-3bk5A:
20.78
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3cf0 TRANSITIONAL
ENDOPLASMIC
RETICULUM ATPASE

(Mus musculus) 		PF00004
(AAA)
PF09336
(Vps4_C) 		3 ARG A 586
ARG A 599
TRP A 551
 None
 1.08A 4cpzG-3cf0A:
undetectable		 4cpzG-3cf0A:
20.17
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3ckz NEURAMINIDASE

(Influenza A
virus) 		PF00064
(Neur) 		3 ARG A 152
ARG A 156
TRP A 178
 ZMR  A 469 (-3.9A)
ZMR  A 469 (-3.4A)
None
 0.80A 4cpzG-3ckzA:
53.1		 4cpzG-3ckzA:
32.40
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3dec BETA-GALACTOSIDASE

(Bacteroides
thetaiotaomicron) 		PF00703
(Glyco_hydro_2)
PF02836
(Glyco_hydro_2_C)
PF02837
(Glyco_hydro_2_N)
PF02929
(Bgal_small_N)
PF16353
(DUF4981) 		3 ARG A 192
ARG A 206
TRP A 193
 None
 1.37A 4cpzG-3decA:
undetectable		 4cpzG-3decA:
18.93
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3gla LOW MOLECULAR WEIGHT
HEAT SHOCK PROTEIN

(Xanthomonas
citri) 		PF00011
(HSP20) 		3 ARG A  84
ARG A 101
TRP A  42
 None
 1.43A 4cpzG-3glaA:
undetectable		 4cpzG-3glaA:
10.59
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3glq ADENOSYLHOMOCYSTEINA
SE

(Burkholderia
pseudomallei) 		PF00670
(AdoHcyase_NAD)
PF05221
(AdoHcyase) 		3 ARG A  82
ARG A 189
TRP A 127
 None
 1.35A 4cpzG-3glqA:
undetectable		 4cpzG-3glqA:
21.95
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3h2i ESTERASE

(Xanthomonas
oryzae) 		PF03583
(LIP) 		3 ARG A 187
ARG A 354
TRP A 322
 None
 1.32A 4cpzG-3h2iA:
undetectable		 4cpzG-3h2iA:
22.94
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3iv0 SUSD HOMOLOG

(Bacteroides
thetaiotaomicron) 		PF07980
(SusD_RagB)
PF14322
(SusD-like_3) 		3 ARG A 162
ARG A 457
TRP A 237
 None
 1.23A 4cpzG-3iv0A:
undetectable		 4cpzG-3iv0A:
22.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3jd5 28S RIBOSOMAL
PROTEIN S5,
MITOCHONDRIAL

(Bos taurus) 		PF00333
(Ribosomal_S5)
PF03719
(Ribosomal_S5_C) 		3 ARG E 128
ARG E 176
TRP E 179
 None
 1.24A 4cpzG-3jd5E:
undetectable		 4cpzG-3jd5E:
22.91
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3jwe MGLL PROTEIN

(Homo sapiens) 		PF12146
(Hydrolase_4) 		3 ARG A  43
ARG A  73
TRP A  45
 None
 0.96A 4cpzG-3jweA:
undetectable		 4cpzG-3jweA:
19.70
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3kpx APOPHOTOPROTEIN
CLYTIN-3

(Clytia gregaria) 		PF13202
(EF-hand_5) 		3 ARG A 176
ARG A 115
TRP A 106
 None
 1.19A 4cpzG-3kpxA:
undetectable		 4cpzG-3kpxA:
19.39
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ml0 PENICILLIN G
ACYLASE, BETA
SUBUNIT

(Alcaligenes
faecalis) 		PF01804
(Penicil_amidase) 		3 ARG B 298
ARG B 295
TRP B 294
 None
 1.31A 4cpzG-3ml0B:
undetectable		 4cpzG-3ml0B:
19.68
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3pfr MANDELATE
RACEMASE/MUCONATE
LACTONIZING PROTEIN

(Actinobacillus
succinogenes) 		PF02746
(MR_MLE_N)
PF13378
(MR_MLE_C) 		3 ARG A 179
ARG A 199
TRP A 175
 None
 1.32A 4cpzG-3pfrA:
undetectable		 4cpzG-3pfrA:
22.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3s1s RESTRICTION
ENDONUCLEASE BPUSI

(Bacillus
pumilus) 		PF02384
(N6_Mtase)
PF15516
(BpuSI_N) 		3 ARG A 481
ARG A 571
TRP A 576
 None
 1.49A 4cpzG-3s1sA:
undetectable		 4cpzG-3s1sA:
19.67
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3sbg PRE-MRNA-SPLICING
FACTOR 8

(Saccharomyces
cerevisiae) 		PF08084
(PROCT)
PF12134
(PRP8_domainIV) 		3 ARG A2388
ARG A2153
TRP A2152
 None
 1.11A 4cpzG-3sbgA:
undetectable		 4cpzG-3sbgA:
22.01
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3ti8 NEURAMINIDASE

(Influenza A
virus) 		PF00064
(Neur) 		3 ARG A 152
ARG A 156
TRP A 178
 LNV  A 901 (-4.0A)
LNV  A 901 (-4.0A)
None
 0.16A 4cpzG-3ti8A:
53.3		 4cpzG-3ti8A:
32.22
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3tia NEURAMINIDASE

(Influenza A
virus) 		PF00064
(Neur) 		3 ARG A 152
ARG A 156
TRP A 178
 LNV  A 801 (-3.9A)
LNV  A 801 (-4.0A)
None
 0.13A 4cpzG-3tiaA:
54.8		 4cpzG-3tiaA:
30.32
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3w7b FORMYLTETRAHYDROFOLA
TE DEFORMYLASE

(Thermus
thermophilus) 		PF00551
(Formyl_trans_N)
PF01842
(ACT) 		3 ARG A 264
ARG A 267
TRP A 268
 None
 1.00A 4cpzG-3w7bA:
undetectable		 4cpzG-3w7bA:
20.50
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4af5 HTH-TYPE
TRANSCRIPTIONAL
REPRESSOR ACNR
COMPND 2

(Corynebacterium
glutamicum) 		PF00440
(TetR_N) 		3 ARG A  99
ARG A  92
TRP A  95
 None
 1.13A 4cpzG-4af5A:
undetectable		 4cpzG-4af5A:
17.31
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4agv GALECTIN

(Cinachyrella) 		PF00337
(Gal-bind_lectin) 		3 ARG A  51
ARG A  47
TRP A  50
 None
 1.37A 4cpzG-4agvA:
undetectable		 4cpzG-4agvA:
15.30
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4b7j NEURAMINIDASE

(Influenza A
virus) 		PF00064
(Neur) 		3 ARG A 152
ARG A 156
TRP A 179
 G39  A1470 (-3.9A)
None
None
 0.18A 4cpzG-4b7jA:
52.5		 4cpzG-4b7jA:
33.95
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4bzk PROTEIN TRANSPORT
PROTEIN SEC31

(Saccharomyces
cerevisiae) 		PF00400
(WD40)
PF12931
(Sec16_C) 		3 ARG A 434
ARG A 680
TRP A 447
 None
 1.40A 4cpzG-4bzkA:
8.9		 4cpzG-4bzkA:
15.44
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4cpn NEURAMINIDASE

(Influenza B
virus) 		PF00064
(Neur) 		3 ARG A 149
ARG A 153
TRP A 176
 ZMR  A 700 (-4.0A)
ZMR  A 700 (-4.2A)
None
 0.17A 4cpzG-4cpnA:
74.8		 4cpzG-4cpnA:
98.50
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4es9 EPF

(Streptococcus
pyogenes) 		no annotation 3 ARG A  79
ARG A 105
TRP A  69
 None
 1.36A 4cpzG-4es9A:
undetectable		 4cpzG-4es9A:
21.80
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4gyp GLUCARATE
DEHYDRATASE-RELATED
PROTEIN

(Escherichia
coli) 		PF02746
(MR_MLE_N)
PF13378
(MR_MLE_C) 		3 ARG C 177
ARG C 197
TRP C 173
 None
 1.26A 4cpzG-4gypC:
undetectable		 4cpzG-4gypC:
19.84
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4h53 NEURAMINIDASE

(Influenza A
virus) 		PF00064
(Neur) 		3 ARG A 152
ARG A 156
TRP A 178
 SLB  A 512 (-3.8A)
None
None
 0.15A 4cpzG-4h53A:
54.6		 4cpzG-4h53A:
28.07
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4hes BETA-LACTAMASE CLASS
A-LIKE PROTEIN

(Veillonella
parvula) 		PF13354
(Beta-lactamase2) 		3 ARG A 182
ARG A 189
TRP A 192
 None
 1.18A 4cpzG-4hesA:
undetectable		 4cpzG-4hesA:
20.90
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4hn8 D-GLUCARATE
DEHYDRATASE

(Pseudomonas
mendocina) 		PF13378
(MR_MLE_C) 		3 ARG A 195
ARG A 215
TRP A 191
 None
 1.32A 4cpzG-4hn8A:
undetectable		 4cpzG-4hn8A:
21.39
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4hzz NEURAMINIDASE

(Influenza A
virus) 		PF00064
(Neur) 		3 ARG A 152
ARG A 156
TRP A 178
 G39  A 509 (-3.9A)
None
None
 0.12A 4cpzG-4hzzA:
52.0		 4cpzG-4hzzA:
30.42
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4kwg ALDEHYDE
DEHYDROGENASE,
MITOCHONDRIAL

(Homo sapiens) 		PF00171
(Aldedh) 		3 ARG A  84
ARG A  77
TRP A  76
 None
GAI  A 605 ( 4.6A)
None
 1.20A 4cpzG-4kwgA:
undetectable		 4cpzG-4kwgA:
22.36
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4mju NEURAMINIDASE

(Influenza A
virus) 		PF00064
(Neur) 		3 ARG A 152
ARG A 156
TRP A 178
 27S  A 501 (-4.2A)
None
None
 0.60A 4cpzG-4mjuA:
51.8		 4cpzG-4mjuA:
31.39
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4p1c TOLUENE-4-MONOOXYGEN
ASE SYSTEM PROTEIN E

(Pseudomonas
mendocina) 		PF02332
(Phenol_Hydrox) 		3 ARG B 200
ARG B 187
TRP B 190
 None
 1.15A 4cpzG-4p1cB:
undetectable		 4cpzG-4p1cB:
20.73
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4pdy AMINOGLYCOSIDE
PHOSPHOTRANSFERASE

(Alicyclobacillus
acidocaldarius) 		PF01636
(APH) 		3 ARG A 166
ARG A 163
TRP A 162
 None
 1.38A 4cpzG-4pdyA:
undetectable		 4cpzG-4pdyA:
18.70
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4qi8 LYTIC POLYSACCHARIDE
MONOOXYGENASE

(Neurospora
crassa) 		PF03443
(Glyco_hydro_61) 		3 ARG A 139
ARG A  41
TRP A  99
 None
 1.40A 4cpzG-4qi8A:
undetectable		 4cpzG-4qi8A:
19.33
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4qn3 NEURAMINIDASE

(Influenza A
virus) 		PF00064
(Neur) 		3 ARG A  70
ARG A  74
TRP A  97
 None
 0.31A 4cpzG-4qn3A:
53.3		 4cpzG-4qn3A:
28.36
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4r7v ARRESTIN
DOMAIN-CONTAINING
PROTEIN 3

(Homo sapiens) 		PF00339
(Arrestin_N) 		3 ARG A  52
ARG A 135
TRP A 137
 None
 1.09A 4cpzG-4r7vA:
undetectable		 4cpzG-4r7vA:
17.17
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4uzu ALPHA-AMYLASE

(Geobacillus
stearothermophilus) 		PF00128
(Alpha-amylase)
PF09154
(DUF1939) 		3 ARG A 355
ARG A 411
TRP A 409
 None
 1.12A 4cpzG-4uzuA:
undetectable		 4cpzG-4uzuA:
21.73
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4whx BRANCHED-CHAIN-AMINO
-ACID TRANSAMINASE

(Burkholderia
pseudomallei) 		PF01063
(Aminotran_4) 		3 ARG A   6
ARG A  20
TRP A  19
 None
 0.97A 4cpzG-4whxA:
undetectable		 4cpzG-4whxA:
21.34
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5abm RETINAL
DEHYDROGENASE 1

(Ovis aries) 		PF00171
(Aldedh) 		3 ARG A  84
ARG A  77
TRP A  76
 None
 1.22A 4cpzG-5abmA:
undetectable		 4cpzG-5abmA:
20.93
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5fhz ALDEHYDE
DEHYDROGENASE FAMILY
1 MEMBER A3

(Homo sapiens) 		PF00171
(Aldedh) 		3 ARG A  96
ARG A  89
TRP A  88
 None
 1.15A 4cpzG-5fhzA:
undetectable		 4cpzG-5fhzA:
22.11
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5igp MACROLIDE
2'-PHOSPHOTRANSFERAS
E

(Escherichia
coli) 		PF01636
(APH) 		3 ARG A 176
ARG A 179
TRP A 180
 None
 1.29A 4cpzG-5igpA:
undetectable		 4cpzG-5igpA:
20.13
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ixp EXTRACELLULAR
SOLUTE-BINDING
PROTEIN FAMILY 1

(Kribbella
flavida) 		PF13416
(SBP_bac_8) 		3 ARG A 164
ARG A 165
TRP A 300
 None
 1.29A 4cpzG-5ixpA:
undetectable		 4cpzG-5ixpA:
22.40
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5vm8 RIBOSOMAL RNA SMALL
SUBUNIT
METHYLTRANSFERASE E

(Neisseria
gonorrhoeae) 		PF04452
(Methyltrans_RNA) 		3 ARG A 124
ARG A 127
TRP A 128
 None
 1.47A 4cpzG-5vm8A:
undetectable		 4cpzG-5vm8A:
20.85
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5wbs FRIZZLED-7,INHIBITOR
PEPTIDE FZ7-21

(Homo sapiens) 		no annotation 3 ARG A  98
ARG A 117
TRP A 112
 None
 1.41A 4cpzG-5wbsA:
undetectable		 4cpzG-5wbsA:
11.31
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5xtc NADH DEHYDROGENASE
[UBIQUINONE] 1 BETA
SUBCOMPLEX SUBUNIT
5, MITOCHONDRIAL

(Homo sapiens) 		no annotation 3 ARG a 123
ARG a 119
TRP a 110
 None
 1.36A 4cpzG-5xtca:
undetectable		 4cpzG-5xtca:
14.38
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5y7o UGGT

(Thermomyces
dupontii) 		PF06427
(UDP-g_GGTase) 		3 ARG A 924
ARG A 927
TRP A 928
 None
 1.17A 4cpzG-5y7oA:
undetectable		 4cpzG-5y7oA:
17.45
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6az1 RIBOSOMAL PROTEIN S4

(Leishmania
donovani) 		no annotation 3 ARG D  39
ARG D  43
TRP D  11
 A  1 643 ( 3.2A)
A  1 521 ( 3.7A)
G  1 520 ( 4.4A)
 1.10A 4cpzG-6az1D:
undetectable		 4cpzG-6az1D:
11.37
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6b5i RETINAL
DEHYDROGENASE 2

(Homo sapiens) 		no annotation 3 ARG A 102
ARG A  95
TRP A  94
 None
 1.24A 4cpzG-6b5iA:
undetectable		 4cpzG-6b5iA:
9.89
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6br6 NEURAMINIDASE

(Influenza A
virus) 		no annotation 3 ARG A 152
ARG A 156
TRP A 178
 E3M  A 511 (-3.8A)
None
None
 0.19A 4cpzG-6br6A:
54.1		 4cpzG-6br6A:
9.01
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6dd6 PHOTOLYASE PHRB

(Agrobacterium
tumefaciens) 		no annotation 3 ARG A 492
ARG A 468
TRP A 484
 None
 1.17A 4cpzG-6dd6A:
undetectable		 4cpzG-6dd6A:
undetectable