SIMILAR PATTERNS OF AMINO ACIDS FOR 4CPZ_B_ZMRB1471_2

List of similar pattern of amino acids derived from ASSAM search

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click link on the last column to view superposed patterns of amino acids in NGL viewer)
(Note that only 3-12 residue patterns can be used for ASSAM searches)
Filter list by:
Hit Macromolecule/
Organism		 Pfam Res. Interface HETATM RMSD Dali Z-score Seq. Identity (%) View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ile ISOLEUCYL-TRNA
SYNTHETASE

(Thermus
thermophilus) 		PF00133
(tRNA-synt_1)
PF08264
(Anticodon_1) 		4 ASP A 496
ARG A 510
ARG A 509
TRP A 459
 None
 1.49A 4cpzB-1ileA:
undetectable		 4cpzB-1ileA:
19.02
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1nmb N9 NEURAMINIDASE

(Influenza A
virus) 		PF00064
(Neur) 		4 ASP N 151
ARG N 152
ARG N 156
TRP N 178
 None
 0.77A 4cpzB-1nmbN:
18.9		 4cpzB-1nmbN:
30.78
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1v0z NEURAMINIDASE

(Influenza A
virus) 		PF00064
(Neur) 		4 ASP A 157
ARG A 158
ARG A 162
TRP A 185
 None
 0.23A 4cpzB-1v0zA:
53.6		 4cpzB-1v0zA:
29.52
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1vcj NEURAMINIDASE

(Influenza B
virus) 		PF00064
(Neur) 		4 ASP A 149
ARG A 150
ARG A 154
TRP A 177
 IBA  A   1 (-3.6A)
IBA  A   1 (-3.9A)
IBA  A   1 (-4.1A)
None
 0.63A 4cpzB-1vcjA:
73.9		 4cpzB-1vcjA:
91.52
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1xog NEURAMINIDASE

(Influenza A
virus) 		PF00064
(Neur) 		4 ASP A 152
ARG A 153
ARG A 157
TRP A 180
 ABW  A1000 (-3.7A)
ABW  A1000 (-4.1A)
ABW  A1000 (-4.2A)
None
 0.47A 4cpzB-1xogA:
19.0		 4cpzB-1xogA:
28.16
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3ckz NEURAMINIDASE

(Influenza A
virus) 		PF00064
(Neur) 		4 ASP A 151
ARG A 152
ARG A 156
TRP A 178
 ZMR  A 469 (-3.5A)
ZMR  A 469 (-3.9A)
ZMR  A 469 (-3.4A)
None
 0.73A 4cpzB-3ckzA:
53.4		 4cpzB-3ckzA:
32.40
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3ti8 NEURAMINIDASE

(Influenza A
virus) 		PF00064
(Neur) 		4 ASP A 151
ARG A 152
ARG A 156
TRP A 178
 LNV  A 901 (-3.4A)
LNV  A 901 (-4.0A)
LNV  A 901 (-4.0A)
None
 0.12A 4cpzB-3ti8A:
53.7		 4cpzB-3ti8A:
32.22
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3tia NEURAMINIDASE

(Influenza A
virus) 		PF00064
(Neur) 		4 ASP A 151
ARG A 152
ARG A 156
TRP A 178
 LNV  A 801 (-3.4A)
LNV  A 801 (-3.9A)
LNV  A 801 (-4.0A)
None
 0.14A 4cpzB-3tiaA:
15.0		 4cpzB-3tiaA:
30.32
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4b7j NEURAMINIDASE

(Influenza A
virus) 		PF00064
(Neur) 		4 ASP A 151
ARG A 152
ARG A 156
TRP A 179
 G39  A1470 (-3.7A)
G39  A1470 (-3.9A)
None
None
 0.19A 4cpzB-4b7jA:
52.8		 4cpzB-4b7jA:
33.95
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4cpn NEURAMINIDASE

(Influenza B
virus) 		PF00064
(Neur) 		4 ASP A 148
ARG A 149
ARG A 153
TRP A 176
 ZMR  A 700 (-3.3A)
ZMR  A 700 (-4.0A)
ZMR  A 700 (-4.2A)
None
 0.13A 4cpzB-4cpnA:
75.4		 4cpzB-4cpnA:
98.50
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4h53 NEURAMINIDASE

(Influenza A
virus) 		PF00064
(Neur) 		4 ASP A 151
ARG A 152
ARG A 156
TRP A 178
 SLB  A 512 (-3.5A)
SLB  A 512 (-3.8A)
None
None
 0.20A 4cpzB-4h53A:
14.8		 4cpzB-4h53A:
28.07
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4hzz NEURAMINIDASE

(Influenza A
virus) 		PF00064
(Neur) 		4 ASP A 151
ARG A 152
ARG A 156
TRP A 178
 G39  A 509 (-3.6A)
G39  A 509 (-3.9A)
None
None
 0.19A 4cpzB-4hzzA:
52.1		 4cpzB-4hzzA:
30.42
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4mju NEURAMINIDASE

(Influenza A
virus) 		PF00064
(Neur) 		4 ASP A 151
ARG A 152
ARG A 156
TRP A 178
 27S  A 501 (-3.2A)
27S  A 501 (-4.2A)
None
None
 0.82A 4cpzB-4mjuA:
52.0		 4cpzB-4mjuA:
31.39
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4qn3 NEURAMINIDASE

(Influenza A
virus) 		PF00064
(Neur) 		4 ASP A  69
ARG A  70
ARG A  74
TRP A  97
 None
 0.35A 4cpzB-4qn3A:
53.4		 4cpzB-4qn3A:
28.36
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6br6 NEURAMINIDASE

(Influenza A
virus) 		no annotation 4 ASP A 151
ARG A 152
ARG A 156
TRP A 178
 E3M  A 511 (-2.9A)
E3M  A 511 (-3.8A)
None
None
 0.28A 4cpzB-6br6A:
14.5		 4cpzB-6br6A:
9.01