SIMILAR PATTERNS OF AMINO ACIDS FOR 4CPZ_A_ZMRA1471_2

List of similar pattern of amino acids derived from ASSAM search

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click link on the last column to view superposed patterns of amino acids in NGL viewer)
(Note that only 3-12 residue patterns can be used for ASSAM searches)
Filter list by:
Hit Macromolecule/
Organism		 Pfam Res. Interface HETATM RMSD Dali Z-score Seq. Identity (%) View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ile ISOLEUCYL-TRNA
SYNTHETASE

(Thermus
thermophilus) 		PF00133
(tRNA-synt_1)
PF08264
(Anticodon_1) 		4 ASP A 496
ARG A 510
ARG A 509
TRP A 459
 None
 1.49A 4cpzA-1ileA:
undetectable		 4cpzA-1ileA:
19.02
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1lur ALDOSE 1-EPIMERASE

(Caenorhabditis
elegans) 		PF01263
(Aldose_epim) 		4 LEU A1126
ASP A1123
ARG A1101
ARG A1063
 None
 1.28A 4cpzA-1lurA:
undetectable		 4cpzA-1lurA:
22.20
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1nmb N9 NEURAMINIDASE

(Influenza A
virus) 		PF00064
(Neur) 		5 LEU N 134
ASP N 151
ARG N 152
ARG N 156
TRP N 178
 None
 0.71A 4cpzA-1nmbN:
53.5		 4cpzA-1nmbN:
30.78
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1qb4 PHOSPHOENOLPYRUVATE
CARBOXYLASE

(Escherichia
coli) 		PF00311
(PEPcase) 		4 LEU A 221
ASP A 378
ARG A 382
ARG A 381
 None
 1.26A 4cpzA-1qb4A:
undetectable		 4cpzA-1qb4A:
20.20
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1v0z NEURAMINIDASE

(Influenza A
virus) 		PF00064
(Neur) 		5 LEU A 140
ASP A 157
ARG A 158
ARG A 162
TRP A 185
 None
 0.20A 4cpzA-1v0zA:
53.7		 4cpzA-1v0zA:
29.52
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1vcj NEURAMINIDASE

(Influenza B
virus) 		PF00064
(Neur) 		5 LEU A 132
ASP A 149
ARG A 150
ARG A 154
TRP A 177
 None
IBA  A   1 (-3.6A)
IBA  A   1 (-3.9A)
IBA  A   1 (-4.1A)
None
 0.61A 4cpzA-1vcjA:
73.9		 4cpzA-1vcjA:
91.52
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1xog NEURAMINIDASE

(Influenza A
virus) 		PF00064
(Neur) 		5 LEU A 135
ASP A 152
ARG A 153
ARG A 157
TRP A 180
 None
ABW  A1000 (-3.7A)
ABW  A1000 (-4.1A)
ABW  A1000 (-4.2A)
None
 0.49A 4cpzA-1xogA:
53.1		 4cpzA-1xogA:
28.16
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2buj SERINE/THREONINE-PRO
TEIN KINASE 16

(Homo sapiens) 		PF00069
(Pkinase) 		4 LEU A  97
ASP A  35
ARG A  50
TRP A  95
 None
 1.42A 4cpzA-2bujA:
undetectable		 4cpzA-2bujA:
19.92
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2htv NEURAMINIDASE

(Influenza A
virus) 		PF00064
(Neur) 		4 LEU A 134
ARG A 152
ARG A 156
TRP A 178
 None
 0.52A 4cpzA-2htvA:
51.8		 4cpzA-2htvA:
31.73
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2htv NEURAMINIDASE

(Influenza A
virus) 		PF00064
(Neur) 		4 LEU A 134
ASP A 151
ARG A 152
TRP A 178
 None
 0.82A 4cpzA-2htvA:
51.8		 4cpzA-2htvA:
31.73
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3ckz NEURAMINIDASE

(Influenza A
virus) 		PF00064
(Neur) 		5 LEU A 134
ASP A 151
ARG A 152
ARG A 156
TRP A 178
 None
ZMR  A 469 (-3.5A)
ZMR  A 469 (-3.9A)
ZMR  A 469 (-3.4A)
None
 0.63A 4cpzA-3ckzA:
53.4		 4cpzA-3ckzA:
32.40
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3g9g SUPPRESSOR OF YEAST
PROFILIN DELETION

(Saccharomyces
cerevisiae) 		no annotation 4 LEU A  94
ASP A  66
ARG A  98
TRP A 101
 None
 1.28A 4cpzA-3g9gA:
undetectable		 4cpzA-3g9gA:
20.33
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3jst PUTATIVE
PTERIN-4-ALPHA-CARBI
NOLAMINE DEHYDRATASE

(Brucella
melitensis) 		PF01329
(Pterin_4a) 		4 LEU A  15
ASP A  19
ARG A  32
TRP A  21
 None
 1.47A 4cpzA-3jstA:
undetectable		 4cpzA-3jstA:
12.02
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3na0 CHOLESTEROL
SIDE-CHAIN CLEAVAGE
ENZYME,
MITOCHONDRIAL

(Homo sapiens) 		PF00067
(p450) 		4 LEU A 441
ASP A 436
ARG A 439
TRP A 440
 None
 1.50A 4cpzA-3na0A:
undetectable		 4cpzA-3na0A:
19.02
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3sdo NITRILOTRIACETATE
MONOOXYGENASE

(Burkholderia
pseudomallei) 		PF00296
(Bac_luciferase) 		4 LEU A 169
ASP A 166
ARG A 204
ARG A 203
 None
 1.36A 4cpzA-3sdoA:
undetectable		 4cpzA-3sdoA:
20.00
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3ti8 NEURAMINIDASE

(Influenza A
virus) 		PF00064
(Neur) 		5 LEU A 134
ASP A 151
ARG A 152
ARG A 156
TRP A 178
 None
LNV  A 901 (-3.4A)
LNV  A 901 (-4.0A)
LNV  A 901 (-4.0A)
None
 0.11A 4cpzA-3ti8A:
53.7		 4cpzA-3ti8A:
32.22
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3tia NEURAMINIDASE

(Influenza A
virus) 		PF00064
(Neur) 		5 LEU A 134
ASP A 151
ARG A 152
ARG A 156
TRP A 178
 None
LNV  A 801 (-3.4A)
LNV  A 801 (-3.9A)
LNV  A 801 (-4.0A)
None
 0.13A 4cpzA-3tiaA:
55.1		 4cpzA-3tiaA:
30.32
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4b7j NEURAMINIDASE

(Influenza A
virus) 		PF00064
(Neur) 		5 LEU A 134
ASP A 151
ARG A 152
ARG A 156
TRP A 179
 None
G39  A1470 (-3.7A)
G39  A1470 (-3.9A)
None
None
 0.19A 4cpzA-4b7jA:
52.9		 4cpzA-4b7jA:
33.95
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4cpn NEURAMINIDASE

(Influenza B
virus) 		PF00064
(Neur) 		5 LEU A 131
ASP A 148
ARG A 149
ARG A 153
TRP A 176
 None
ZMR  A 700 (-3.3A)
ZMR  A 700 (-4.0A)
ZMR  A 700 (-4.2A)
None
 0.12A 4cpzA-4cpnA:
75.5		 4cpzA-4cpnA:
98.50
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4fnq ALPHA-GALACTOSIDASE
AGAB

(Geobacillus
stearothermophilus) 		PF02065
(Melibiase)
PF16874
(Glyco_hydro_36C)
PF16875
(Glyco_hydro_36N) 		4 LEU A 380
ASP A 376
ARG A 377
ARG A 373
 None
 1.42A 4cpzA-4fnqA:
undetectable		 4cpzA-4fnqA:
20.95
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4h53 NEURAMINIDASE

(Influenza A
virus) 		PF00064
(Neur) 		5 LEU A 134
ASP A 151
ARG A 152
ARG A 156
TRP A 178
 None
SLB  A 512 (-3.5A)
SLB  A 512 (-3.8A)
None
None
 0.19A 4cpzA-4h53A:
55.0		 4cpzA-4h53A:
28.07
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4hzz NEURAMINIDASE

(Influenza A
virus) 		PF00064
(Neur) 		5 LEU A 134
ASP A 151
ARG A 152
ARG A 156
TRP A 178
 None
G39  A 509 (-3.6A)
G39  A 509 (-3.9A)
None
None
 0.14A 4cpzA-4hzzA:
52.3		 4cpzA-4hzzA:
30.42
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4j0w U3 SMALL NUCLEOLAR
RNA-INTERACTING
PROTEIN 2

(Homo sapiens) 		PF00400
(WD40) 		4 LEU A 415
ASP A 417
ARG A 401
TRP A 403
 None
 1.37A 4cpzA-4j0wA:
4.4		 4cpzA-4j0wA:
19.67
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4mju NEURAMINIDASE

(Influenza A
virus) 		PF00064
(Neur) 		5 LEU A 134
ASP A 151
ARG A 152
ARG A 156
TRP A 178
 None
27S  A 501 (-3.2A)
27S  A 501 (-4.2A)
None
None
 0.74A 4cpzA-4mjuA:
52.1		 4cpzA-4mjuA:
31.39
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4nnb OBCA, OXALATE
BIOSYNTHETIC
COMPONENT A

(Burkholderia
glumae) 		PF05853
(BKACE) 		4 LEU A 408
ASP A 415
ARG A 418
ARG A 419
 None
 1.44A 4cpzA-4nnbA:
undetectable		 4cpzA-4nnbA:
21.64
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4psw HISTONE
ACETYLTRANSFERASE
TYPE B SUBUNIT 2
HISTONE H4 TYPE VIII

(Ophiophagus
hannah;
Saccharomyces
cerevisiae) 		PF00400
(WD40)
PF12265
(CAF1C_H4-bd)
no annotation 		4 LEU B 344
ASP B 339
ARG C  42
ARG C  41
 None
 1.32A 4cpzA-4pswB:
9.5		 4cpzA-4pswB:
22.16
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4qn3 NEURAMINIDASE

(Influenza A
virus) 		PF00064
(Neur) 		5 LEU A  52
ASP A  69
ARG A  70
ARG A  74
TRP A  97
 None
 0.32A 4cpzA-4qn3A:
12.1		 4cpzA-4qn3A:
28.36
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5j55 CAROTENOID OXYGENASE

(Novosphingobium
aromaticivorans) 		PF03055
(RPE65) 		4 LEU A 391
ASP A 375
ARG A 378
TRP A 409
 None
 1.36A 4cpzA-5j55A:
5.8		 4cpzA-5j55A:
20.82
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5l6m RIBONUCLEASE VAPC
VAPB FAMILY PROTEIN

(Caulobacter
vibrioides) 		PF01850
(PIN)
PF04014
(MazE_antitoxin) 		4 LEU A  56
ASP B  15
ARG B  14
ARG B  58
 None
 1.18A 4cpzA-5l6mA:
undetectable		 4cpzA-5l6mA:
9.01
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6br6 NEURAMINIDASE

(Influenza A
virus) 		no annotation 5 LEU A 134
ASP A 151
ARG A 152
ARG A 156
TRP A 178
 None
E3M  A 511 (-2.9A)
E3M  A 511 (-3.8A)
None
None
 0.23A 4cpzA-6br6A:
54.1		 4cpzA-6br6A:
9.01