SIMILAR PATTERNS OF AMINO ACIDS FOR 4CP4_A_CAMA416_0

List of similar pattern of amino acids derived from ASSAM search

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click link on the last column to view superposed patterns of amino acids in NGL viewer)
(Note that only 3-12 residue patterns can be used for ASSAM searches)
Filter list by:
Hit Macromolecule/
Organism		 Pfam Res. Interface HETATM RMSD Dali Z-score Seq. Identity (%) View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1bwd PROTEIN
(INOSAMINE-PHOSPHATE
AMIDINOTRANSFERASE)

(Streptomyces
griseus) 		no annotation 4 THR A 334
LEU A 318
VAL A  79
VAL A  16
 None
 0.90A 4cp4A-1bwdA:
undetectable		 4cp4A-1bwdA:
20.90
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ev1 ECHOVIRUS 1

(Enterovirus B) 		PF00073
(Rhv) 		4 THR 2 199
LEU 2  18
VAL 2  33
VAL 2  31
 None
 0.97A 4cp4A-1ev12:
0.0		 4cp4A-1ev12:
18.27
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1fwx NITROUS OXIDE
REDUCTASE

(Paracoccus
denitrificans) 		PF13473
(Cupredoxin_1) 		4 PHE A 549
TYR A 533
VAL A 487
VAL A 489
 None
 0.92A 4cp4A-1fwxA:
0.0		 4cp4A-1fwxA:
19.74
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1he3 BILIVERDIN IX BETA
REDUCTASE

(Homo sapiens) 		PF13460
(NAD_binding_10) 		4 TYR A 163
THR A 199
VAL A 107
VAL A 147
 None
 0.97A 4cp4A-1he3A:
0.0		 4cp4A-1he3A:
21.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1j3b ATP-DEPENDENT
PHOSPHOENOLPYRUVATE
CARBOXYKINASE

(Thermus
thermophilus) 		PF01293
(PEPCK_ATP) 		4 THR A 153
VAL A 101
ASP A 103
VAL A 119
 None
 0.90A 4cp4A-1j3bA:
0.0		 4cp4A-1j3bA:
21.62
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1j6u UDP-N-ACETYLMURAMATE
-ALANINE LIGASE MURC

(Thermotoga
maritima) 		PF01225
(Mur_ligase)
PF02875
(Mur_ligase_C)
PF08245
(Mur_ligase_M) 		4 THR A 230
LEU A 284
VAL A 208
VAL A 222
 None
 0.97A 4cp4A-1j6uA:
0.0		 4cp4A-1j6uA:
21.76
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1k7j PROTEIN YCIO

(Escherichia
coli) 		PF01300
(Sua5_yciO_yrdC) 		4 THR A  98
VAL A 195
ASP A 186
VAL A 184
 SO4  A 207 ( 4.9A)
None
None
None
 0.79A 4cp4A-1k7jA:
undetectable		 4cp4A-1k7jA:
20.10
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ko0 DIAMINOPIMELATE
DECARBOXYLASE

(Escherichia
coli) 		PF00278
(Orn_DAP_Arg_deC)
PF02784
(Orn_Arg_deC_N) 		4 THR A 335
LEU A 327
VAL A 287
VAL A 296
 None
 1.00A 4cp4A-1ko0A:
undetectable		 4cp4A-1ko0A:
21.49
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1mi1 NEUROBEACHIN

(Homo sapiens) 		PF02138
(Beach)
PF14844
(PH_BEACH) 		4 PHE A2231
LEU A2144
VAL A2205
VAL A2219
 None
 1.01A 4cp4A-1mi1A:
0.0		 4cp4A-1mi1A:
21.57
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1mk4 HYPOTHETICAL PROTEIN
YQJY

(Bacillus
subtilis) 		PF00583
(Acetyltransf_1) 		4 THR A 108
VAL A 138
ASP A 148
VAL A 150
 None
 0.85A 4cp4A-1mk4A:
undetectable		 4cp4A-1mk4A:
14.83
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1od6 PHOSPHOPANTETHEINE
ADENYLYLTRANSFERASE

(Thermus
thermophilus) 		PF01467
(CTP_transf_like) 		4 THR A 150
LEU A  45
VAL A 142
VAL A 146
 None
 0.95A 4cp4A-1od6A:
undetectable		 4cp4A-1od6A:
19.38
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1r6b CLPA PROTEIN

(Escherichia
coli) 		PF00004
(AAA)
PF02861
(Clp_N)
PF07724
(AAA_2)
PF10431
(ClpB_D2-small) 		4 PHE X 493
LEU X 456
VAL X 560
VAL X 600
 None
 0.81A 4cp4A-1r6bX:
undetectable		 4cp4A-1r6bX:
21.67
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ryy ALPHA-AMINO ACID
ESTER HYDROLASE

(Acetobacter
pasteurianus) 		PF02129
(Peptidase_S15)
PF08530
(PepX_C) 		4 THR A 447
LEU A 457
VAL A 524
VAL A 664
 None
 0.73A 4cp4A-1ryyA:
undetectable		 4cp4A-1ryyA:
21.58
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1tf0 SERUM ALBUMIN

(Homo sapiens) 		PF00273
(Serum_albumin) 		4 THR A 422
LEU A 457
VAL A 415
VAL A 418
 None
 0.98A 4cp4A-1tf0A:
undetectable		 4cp4A-1tf0A:
22.18
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1xvi PUTATIVE
MANNOSYL-3-PHOSPHOGL
YCERATE PHOSPHATASE

(Escherichia
coli) 		PF08282
(Hydrolase_3) 		4 PHE A 115
THR A 117
VAL A 181
VAL A 147
 None
 0.99A 4cp4A-1xviA:
undetectable		 4cp4A-1xviA:
22.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1y7o ATP-DEPENDENT CLP
PROTEASE PROTEOLYTIC
SUBUNIT

(Streptococcus
pneumoniae) 		PF00574
(CLP_protease) 		4 PHE A 185
TYR A 183
THR A  99
VAL A 100
 None
 1.01A 4cp4A-1y7oA:
undetectable		 4cp4A-1y7oA:
20.10
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1yv9 HYDROLASE, HALOACID
DEHALOGENASE FAMILY

(Enterococcus
faecalis) 		PF13242
(Hydrolase_like)
PF13344
(Hydrolase_6) 		4 THR A 174
LEU A 143
VAL A 167
VAL A 170
 None
 0.89A 4cp4A-1yv9A:
undetectable		 4cp4A-1yv9A:
22.53
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1z0n 5'-AMP-ACTIVATED
PROTEIN KINASE,
BETA-1 SUBUNIT

(Rattus
norvegicus) 		PF16561
(AMPK1_CBM) 		4 TYR A 125
THR A 134
VAL A  91
VAL A 129
 None
 0.98A 4cp4A-1z0nA:
undetectable		 4cp4A-1z0nA:
13.19
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1zpu IRON TRANSPORT
MULTICOPPER OXIDASE
FET3

(Saccharomyces
cerevisiae) 		PF00394
(Cu-oxidase)
PF07731
(Cu-oxidase_2)
PF07732
(Cu-oxidase_3) 		4 TYR A 362
THR A 392
VAL A 479
VAL A 499
 None
 0.87A 4cp4A-1zpuA:
undetectable		 4cp4A-1zpuA:
21.14
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2f02 TAGATOSE-6-PHOSPHATE
KINASE

(Enterococcus
faecalis) 		PF00294
(PfkB) 		4 THR A  56
LEU A 118
VAL A 131
VAL A   3
 None
 0.93A 4cp4A-2f02A:
undetectable		 4cp4A-2f02A:
22.10
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2is8 MOLYBDOPTERIN
BIOSYNTHESIS ENZYME,
MOAB

(Thermus
thermophilus) 		PF00994
(MoCF_biosynth) 		4 THR A  68
LEU A  87
VAL A  43
VAL A   9
 None
 0.99A 4cp4A-2is8A:
undetectable		 4cp4A-2is8A:
16.67
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2jls SERINE PROTEASE
SUBUNIT NS3

(Dengue virus) 		PF07652
(Flavi_DEAD) 		4 THR A 407
VAL A 422
ASP A 424
VAL A 359
 None
 0.90A 4cp4A-2jlsA:
undetectable		 4cp4A-2jlsA:
22.36
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2m56 CAMPHOR
5-MONOOXYGENASE

(Pseudomonas
putida) 		PF00067
(p450) 		7 PHE A  87
TYR A  96
THR A 185
LEU A 244
VAL A 295
ASP A 297
VAL A 396
 CAM  A 502 (-4.6A)
CAM  A 502 (-4.5A)
None
HEM  A 501 (-4.5A)
HEM  A 501 (-4.6A)
HEM  A 501 (-2.8A)
None
 0.29A 4cp4A-2m56A:
67.7		 4cp4A-2m56A:
99.75
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2nyz HYPOTHETICAL PROTEIN
GAMMAHV.M3

(Murid
gammaherpesvirus
4) 		PF09213
(M3) 		4 THR A 183
LEU A  65
VAL A 153
VAL A 110
 None
 0.88A 4cp4A-2nyzA:
undetectable		 4cp4A-2nyzA:
21.28
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2o1b AMINOTRANSFERASE,
CLASS I

(Staphylococcus
aureus) 		PF00155
(Aminotran_1_2) 		4 PHE A 190
THR A 162
LEU A 167
VAL A 154
 None
 0.97A 4cp4A-2o1bA:
undetectable		 4cp4A-2o1bA:
22.03
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2o1e YCDH

(Bacillus
subtilis) 		PF01297
(ZnuA) 		4 THR A  21
LEU A  17
VAL A  95
VAL A  70
 None
 0.97A 4cp4A-2o1eA:
undetectable		 4cp4A-2o1eA:
19.52
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2qeq FLAVIVIRIN PROTEASE
NS3 CATALYTIC
SUBUNIT

(West Nile virus) 		PF00271
(Helicase_C)
PF07652
(Flavi_DEAD) 		4 THR A 408
VAL A 423
ASP A 425
VAL A 360
 None
 0.93A 4cp4A-2qeqA:
undetectable		 4cp4A-2qeqA:
21.89
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2qzp ACYLAMINO-ACID-RELEA
SING ENZYME

(Aeropyrum
pernix) 		PF00326
(Peptidase_S9) 		4 TYR A 444
LEU A 568
VAL A 392
VAL A 363
 None
 0.96A 4cp4A-2qzpA:
undetectable		 4cp4A-2qzpA:
21.49
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2r3v MEVALONATE KINASE

(Homo sapiens) 		PF00288
(GHMP_kinases_N)
PF08544
(GHMP_kinases_C) 		4 THR A 332
LEU A 343
VAL A  31
VAL A  14
 None
 0.98A 4cp4A-2r3vA:
undetectable		 4cp4A-2r3vA:
26.09
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2v6j RNA HELICASE

(Kokobera virus) 		PF00271
(Helicase_C)
PF07652
(Flavi_DEAD) 		4 THR A 223
VAL A 238
ASP A 240
VAL A 175
 None
 0.84A 4cp4A-2v6jA:
undetectable		 4cp4A-2v6jA:
21.87
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2v7g UROCANATE HYDRATASE

(Pseudomonas
putida) 		PF01175
(Urocanase)
PF17391
(Urocanase_N)
PF17392
(Urocanase_C) 		4 THR A 484
LEU A  72
VAL A 439
VAL A 507
 None
 0.97A 4cp4A-2v7gA:
undetectable		 4cp4A-2v7gA:
22.57
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2v8o FLAVIVIRIN PROTEASE
NS3

(Murray Valley
encephalitis
virus) 		PF00271
(Helicase_C)
PF07652
(Flavi_DEAD) 		4 THR A 408
VAL A 423
ASP A 425
VAL A 360
 None
 0.90A 4cp4A-2v8oA:
undetectable		 4cp4A-2v8oA:
20.70
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2whx SERINE
PROTEASE/NTPASE/HELI
CASE NS3

(Dengue virus) 		PF00949
(Peptidase_S7)
PF07652
(Flavi_DEAD) 		4 THR A 407
VAL A 422
ASP A 424
VAL A 359
 None
 0.94A 4cp4A-2whxA:
undetectable		 4cp4A-2whxA:
21.82
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2wv9 FLAVIVIRIN PROTEASE
NS2B REGULATORY
SUBUNIT, FLAVIVIRIN
PROTEASE NS3
CATALYTIC SUBUNIT

(Murray Valley
encephalitis
virus) 		PF00271
(Helicase_C)
PF00949
(Peptidase_S7)
PF01002
(Flavi_NS2B)
PF07652
(Flavi_DEAD) 		4 THR A 408
VAL A 423
ASP A 425
VAL A 360
 None
 1.01A 4cp4A-2wv9A:
undetectable		 4cp4A-2wv9A:
20.55
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2x86 ADP-L-GLYCERO-D-MANN
O-HEPTOSE-6-EPIMERAS
E

(Escherichia
coli) 		PF01370
(Epimerase) 		4 THR A 250
LEU A 200
VAL A 295
VAL A 299
 None
ADP  A 401 (-4.3A)
None
None
 0.97A 4cp4A-2x86A:
undetectable		 4cp4A-2x86A:
21.33
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2y5i S100 CALCIUM BINDING
PROTEIN Z

(Danio rerio) 		PF01023
(S_100) 		4 THR A  83
LEU A   5
VAL A  76
VAL A  79
 None
 0.87A 4cp4A-2y5iA:
undetectable		 4cp4A-2y5iA:
14.55
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2z83 HELICASE/NUCLEOSIDE
TRIPHOSPHATASE

(Japanese
encephalitis
virus) 		PF00271
(Helicase_C)
PF07652
(Flavi_DEAD) 		4 THR A 408
VAL A 423
ASP A 425
VAL A 360
 None
 0.98A 4cp4A-2z83A:
undetectable		 4cp4A-2z83A:
22.09
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2zwv PROBABLE RIBOSOMAL
RNA SMALL SUBUNIT
METHYLTRANSFERASE

(Thermus
thermophilus) 		PF05175
(MTS) 		4 LEU A 220
VAL A 258
ASP A 239
VAL A 237
 None
None
SAH  A 376 ( 4.2A)
None
 1.00A 4cp4A-2zwvA:
undetectable		 4cp4A-2zwvA:
24.85
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3cn7 CARBOXYLESTERASE

(Pseudomonas
aeruginosa) 		PF02230
(Abhydrolase_2) 		4 PHE A  45
THR A  43
LEU A 135
VAL A  39
 None
 0.81A 4cp4A-3cn7A:
undetectable		 4cp4A-3cn7A:
20.94
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3elu METHYLTRANSFERASE

(Wesselsbron
virus) 		PF00972
(Flavi_NS5)
PF01728
(FtsJ) 		4 THR A 142
VAL A 100
ASP A  79
VAL A  77
 None
 1.01A 4cp4A-3eluA:
undetectable		 4cp4A-3eluA:
21.31
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3fbq CONSERVED DOMAIN
PROTEIN

(Bacillus
anthracis) 		PF13786
(DUF4179) 		4 TYR A  24
THR A 103
LEU A  20
ASP A  50
 None
 0.82A 4cp4A-3fbqA:
undetectable		 4cp4A-3fbqA:
20.62
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3gcz POLYPROTEIN

(Yokose virus) 		PF01728
(FtsJ) 		4 THR A 142
VAL A 100
ASP A  79
VAL A  77
 None
 0.99A 4cp4A-3gczA:
undetectable		 4cp4A-3gczA:
20.24
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3geh TRNA MODIFICATION
GTPASE MNME

(Nostoc sp. PCC
7120) 		PF01926
(MMR_HSR1)
PF10396
(TrmE_N)
PF12631
(MnmE_helical) 		4 LEU A 237
VAL A 266
ASP A 245
VAL A 271
 None
 1.01A 4cp4A-3gehA:
undetectable		 4cp4A-3gehA:
23.45
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3gxv REPLICATIVE DNA
HELICASE

(Helicobacter
pylori) 		PF00772
(DnaB) 		4 PHE A  40
LEU A  53
ASP A  39
VAL A  98
 None
 0.69A 4cp4A-3gxvA:
undetectable		 4cp4A-3gxvA:
14.85
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3i5g MYOSIN HEAVY CHAIN
ISOFORM A

(Doryteuthis
pealeii) 		PF00063
(Myosin_head)
PF00612
(IQ)
PF02736
(Myosin_N) 		4 THR A 448
LEU A 220
ASP A 266
VAL A 445
 None
 0.96A 4cp4A-3i5gA:
undetectable		 4cp4A-3i5gA:
19.10
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ib5 SEX PHEROMONE
PRECURSOR

(Lactobacillus
salivarius) 		PF07537
(CamS) 		4 TYR A 101
THR A 169
VAL A 246
VAL A 224
 None
None
EDO  A   3 ( 4.0A)
None
 1.00A 4cp4A-3ib5A:
undetectable		 4cp4A-3ib5A:
22.58
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3kwu MUNC13-1

(Rattus
norvegicus) 		PF00168
(C2) 		4 THR A 781
LEU A 788
VAL A 716
VAL A 753
 None
 0.93A 4cp4A-3kwuA:
undetectable		 4cp4A-3kwuA:
16.07
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3rku OXIDOREDUCTASE
YMR226C

(Saccharomyces
cerevisiae) 		PF00106
(adh_short) 		4 LEU A  11
VAL A 151
ASP A 149
VAL A 100
 None
 0.83A 4cp4A-3rkuA:
undetectable		 4cp4A-3rkuA:
21.62
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3rva ORGANOPHOSPHORUS
ACID ANHYDROLASE

(Alteromonas
macleodii) 		PF00557
(Peptidase_M24) 		4 THR A  79
LEU A 109
VAL A  32
VAL A  71
 None
 0.89A 4cp4A-3rvaA:
undetectable		 4cp4A-3rvaA:
22.27
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3s5k FALCILYSIN

(Plasmodium
falciparum) 		PF00675
(Peptidase_M16)
PF05193
(Peptidase_M16_C)
PF08367
(M16C_assoc) 		4 THR A 169
LEU A 136
VAL A 301
VAL A 117
 None
 0.97A 4cp4A-3s5kA:
undetectable		 4cp4A-3s5kA:
15.90
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3sim PROTEIN, FAMILY 18
CHITINASE

(Crocus vernus) 		PF00704
(Glyco_hydro_18) 		4 PHE A  94
LEU A 172
VAL A 103
VAL A  99
 None
 0.94A 4cp4A-3simA:
undetectable		 4cp4A-3simA:
20.91
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3t6g SH2
DOMAIN-CONTAINING
PROTEIN 3C

(Homo sapiens) 		PF00617
(RasGEF) 		4 PHE A 586
LEU A 590
VAL A 444
ASP A 441
 None
 0.95A 4cp4A-3t6gA:
undetectable		 4cp4A-3t6gA:
22.45
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3tcr MOLYBDOPTERIN
BIOSYNTHESIS PROTEIN

(Mycobacteroides
abscessus) 		PF00994
(MoCF_biosynth) 		4 THR A  87
LEU A 106
VAL A  63
VAL A  30
 None
 0.95A 4cp4A-3tcrA:
undetectable		 4cp4A-3tcrA:
19.07
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3wgk CELL DIVISION
PROTEIN FTSZ

(Staphylococcus
aureus) 		PF00091
(Tubulin)
PF12327
(FtsZ_C) 		4 THR A 294
LEU A 300
VAL A 203
ASP A 199
 None
 0.81A 4cp4A-3wgkA:
undetectable		 4cp4A-3wgkA:
21.24
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3wyr KILLER CELL
IMMUNOGLOBULIN-LIKE
RECEPTOR 2DL4

(Homo sapiens) 		PF00047
(ig) 		4 TYR A  72
LEU A  50
VAL A  18
VAL A  96
 None
 1.01A 4cp4A-3wyrA:
undetectable		 4cp4A-3wyrA:
20.91
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4b4u BIFUNCTIONAL PROTEIN
FOLD

(Acinetobacter
baumannii) 		PF00763
(THF_DHG_CYH)
PF02882
(THF_DHG_CYH_C) 		4 THR A  73
LEU A  79
VAL A 100
VAL A  40
 None
 1.01A 4cp4A-4b4uA:
undetectable		 4cp4A-4b4uA:
21.94
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4bof ARGININE DEIMINASE

(Streptococcus
pyogenes) 		PF02274
(Amidinotransf) 		4 TYR A 202
THR A 170
LEU A  69
VAL A   9
 None
 0.74A 4cp4A-4bofA:
undetectable		 4cp4A-4bofA:
23.78
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4c9m CYTOCHROME P450

(Novosphingobium
aromaticivorans) 		PF00067
(p450) 		6 TYR A  98
THR A 187
LEU A 252
VAL A 303
ASP A 305
VAL A 404
 None
None
HEM  A1418 (-4.0A)
GOL  A1419 (-3.9A)
HEM  A1418 (-2.7A)
GOL  A1419 (-3.5A)
 0.54A 4cp4A-4c9mA:
58.7		 4cp4A-4c9mA:
44.92
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4cyf PANTETHEINASE

(Homo sapiens) 		PF00795
(CN_hydrolase) 		4 LEU A 223
VAL A 136
ASP A 163
VAL A 165
 None
 1.01A 4cp4A-4cyfA:
undetectable		 4cp4A-4cyfA:
22.44
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4d7a TRNA
THREONYLCARBAMOYLADE
NOSINE DEHYDRATASE

(Escherichia
coli) 		PF00899
(ThiF) 		4 THR A 152
VAL A 166
ASP A 202
VAL A 204
 None
GOL  A 501 ( 4.8A)
GOL  A 502 (-4.1A)
None
 0.78A 4cp4A-4d7aA:
undetectable		 4cp4A-4d7aA:
21.48
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4de8 CPS2A

(Streptococcus
pneumoniae) 		PF02916
(DNA_PPF)
PF03816
(LytR_cpsA_psr) 		4 TYR A 167
LEU A 114
VAL A 161
VAL A 133
 None
 0.98A 4cp4A-4de8A:
undetectable		 4cp4A-4de8A:
22.75
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4dxy CYTOCHROME P450

(Novosphingobium
aromaticivorans) 		PF00067
(p450) 		4 PHE A  87
LEU A 250
VAL A 301
VAL A 402
 None
HEM  A 501 (-4.3A)
PEG  A 502 ( 4.5A)
None
 0.78A 4cp4A-4dxyA:
52.0		 4cp4A-4dxyA:
46.24
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4em7 DNA TOPOISOMERASE
IV, B SUBUNIT

(Streptococcus
pneumoniae) 		PF02518
(HATPase_c) 		4 LEU A 204
VAL A  76
ASP A  78
VAL A  66
 None
None
0RA  A 301 (-3.6A)
None
 1.00A 4cp4A-4em7A:
undetectable		 4cp4A-4em7A:
19.42
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4emk U6 SNRNA-ASSOCIATED
SM-LIKE PROTEIN LSM6

(Schizosaccharomyces
pombe) 		PF01423
(LSM) 		4 TYR B  57
THR B  54
VAL B  25
VAL B  49
 None
 0.85A 4cp4A-4emkB:
undetectable		 4cp4A-4emkB:
11.32
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4hhu OR280

(synthetic
construct) 		no annotation 4 THR A 118
LEU A  16
VAL A  88
VAL A 125
 None
 0.91A 4cp4A-4hhuA:
undetectable		 4cp4A-4hhuA:
18.29
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4kbm DNA-DIRECTED RNA
POLYMERASE SUBUNIT
BETA

(Mycobacterium
tuberculosis) 		PF04561
(RNA_pol_Rpb2_2)
PF04563
(RNA_pol_Rpb2_1) 		4 THR A 255
VAL A 210
ASP A 214
VAL A 216
 None
 0.82A 4cp4A-4kbmA:
undetectable		 4cp4A-4kbmA:
19.82
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4kdw ANTIFREEZE PROTEIN

(Marinomonas
primoryensis) 		no annotation 4 THR A  56
VAL A  83
ASP A  43
VAL A  45
 None
None
GOL  A 208 (-4.4A)
None
 0.89A 4cp4A-4kdwA:
undetectable		 4cp4A-4kdwA:
14.49
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4lhs UNCHARACTERIZED
PROTEIN

(Bacteroides
ovatus) 		PF14606
(Lipase_GDSL_3)
PF14607
(GxDLY) 		4 PHE A 343
LEU A 153
ASP A 340
VAL A 333
 None
 1.01A 4cp4A-4lhsA:
undetectable		 4cp4A-4lhsA:
20.24
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4n91 TRAP DICARBOXYLATE
TRANSPORTER, DCTP
SUBUNIT

(Anaerococcus
prevotii) 		PF03480
(DctP) 		4 THR A 147
VAL A  93
ASP A 242
VAL A 244
 None
None
GCU  A 401 ( 2.7A)
None
 0.80A 4cp4A-4n91A:
undetectable		 4cp4A-4n91A:
21.21
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4nec PUTATIVE
SAM-DEPENDENT
METHYLTRANSFERASE

(Streptomyces
lasaliensis) 		PF13649
(Methyltransf_25) 		4 THR A 107
VAL A  64
ASP A  45
VAL A  43
 None
None
SAH  A 401 ( 4.7A)
None
 1.00A 4cp4A-4necA:
undetectable		 4cp4A-4necA:
21.68
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4nwv CAPSID PROTEIN

(Orsay virus) 		PF11729
(Capsid-VNN) 		4 THR A 152
LEU A 137
VAL A 199
VAL A 103
 None
 0.75A 4cp4A-4nwvA:
undetectable		 4cp4A-4nwvA:
22.64
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4nww CAPSID PROTEIN

(Orsay virus) 		PF11729
(Capsid-VNN) 		4 THR A 152
LEU A 137
VAL A 199
VAL A 103
 None
 0.75A 4cp4A-4nwwA:
undetectable		 4cp4A-4nwwA:
22.07
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4p7c TRNA
(MO5U34)-METHYLTRANS
FERASE

(Pseudomonas
syringae group
genomosp. 3) 		PF08003
(Methyltransf_9) 		4 THR A 188
VAL A 144
ASP A 124
VAL A 122
 None
 1.00A 4cp4A-4p7cA:
undetectable		 4cp4A-4p7cA:
23.36
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4p99 MPAFP_RII
TETRA-TANDEMER

(Marinomonas
primoryensis) 		no annotation 4 THR A  56
VAL A  83
ASP A  43
VAL A  45
 None
None
CA  A 510 ( 4.9A)
None
 0.90A 4cp4A-4p99A:
undetectable		 4cp4A-4p99A:
21.01
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4p99 MPAFP_RII
TETRA-TANDEMER

(Marinomonas
primoryensis) 		no annotation 4 THR A 160
VAL A 187
ASP A 147
VAL A 149
 None
None
CA  A 507 ( 4.9A)
None
 0.88A 4cp4A-4p99A:
undetectable		 4cp4A-4p99A:
21.01
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4p99 MPAFP_RII
TETRA-TANDEMER

(Marinomonas
primoryensis) 		no annotation 4 THR A 264
VAL A 291
ASP A 251
VAL A 253
 None
None
CA  A 520 ( 4.7A)
None
 0.91A 4cp4A-4p99A:
undetectable		 4cp4A-4p99A:
21.01
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4p99 MPAFP_RII
TETRA-TANDEMER

(Marinomonas
primoryensis) 		no annotation 4 THR A 368
VAL A 395
ASP A 355
VAL A 357
 None
 0.92A 4cp4A-4p99A:
undetectable		 4cp4A-4p99A:
21.01
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4rl3 CHITINASE A

(Pteris
ryukyuensis) 		PF00704
(Glyco_hydro_18) 		4 PHE A 214
LEU A 292
VAL A 223
VAL A 219
 None
 0.99A 4cp4A-4rl3A:
undetectable		 4cp4A-4rl3A:
20.14
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4trr PUTATIVE
D-BETA-HYDROXYBUTYRA
TE DEHYDROGENASE

(Burkholderia
cenocepacia) 		PF00106
(adh_short) 		4 THR A 121
LEU A 163
ASP A 116
VAL A  64
 None
 0.97A 4cp4A-4trrA:
undetectable		 4cp4A-4trrA:
20.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4xwt DR2417

(Deinococcus
radiodurans) 		PF00753
(Lactamase_B)
PF07521
(RMMBL) 		4 THR A  35
VAL A 435
ASP A 433
VAL A  21
 None
 0.93A 4cp4A-4xwtA:
undetectable		 4cp4A-4xwtA:
20.32
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4yef 5'-AMP-ACTIVATED
PROTEIN KINASE
SUBUNIT BETA-1

(Rattus
norvegicus) 		PF16561
(AMPK1_CBM) 		4 TYR A 125
THR A 134
VAL A  91
VAL A 129
 None
 0.89A 4cp4A-4yefA:
undetectable		 4cp4A-4yefA:
12.76
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4yry DIHYDROOROTATE
DEHYDROGENASE B
(NAD(+)), ELECTRON
TRANSFER SUBUNIT
HOMOLOG
DIHYDROPYRIMIDINE
DEHYDROGENASE
SUBUNIT A

(Thermotoga
maritima;
Thermotoga
maritima) 		PF00175
(NAD_binding_1)
PF00970
(FAD_binding_6)
PF10418
(DHODB_Fe-S_bind)
PF07992
(Pyr_redox_2)
PF14691
(Fer4_20) 		4 LEU B 263
VAL A  91
ASP A  89
VAL A  40
 None
 0.84A 4cp4A-4yryB:
undetectable		 4cp4A-4yryB:
22.63
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4zc0 REPLICATIVE DNA
HELICASE

(Helicobacter
pylori) 		PF00772
(DnaB)
PF03796
(DnaB_C) 		4 PHE A  40
LEU A  53
ASP A  39
VAL A  98
 None
 0.55A 4cp4A-4zc0A:
undetectable		 4cp4A-4zc0A:
21.19
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5a7y TRNA
(ADENINE(9)-N1)-METH
YLTRANSFERASE

(Sulfolobus
acidocaldarius) 		no annotation 4 THR A 129
VAL A 178
ASP A  93
VAL A  91
 None
 0.93A 4cp4A-5a7yA:
undetectable		 4cp4A-5a7yA:
21.21
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5aca VP3

(Foot-and-mouth
disease virus) 		PF00073
(Rhv) 		4 PHE 3  76
THR 3  74
VAL 3 122
VAL 3 188
 None
 0.99A 4cp4A-5aca3:
undetectable		 4cp4A-5aca3:
18.93
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5bp7 SAM-DEPENDENT
METHYLTRANSFERASE

(Geobacter
sulfurreducens) 		PF13847
(Methyltransf_31) 		4 LEU A  26
VAL A  41
ASP A  43
VAL A 107
 None
None
SAH  A 301 ( 4.5A)
None
 0.97A 4cp4A-5bp7A:
undetectable		 4cp4A-5bp7A:
20.57
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5eks 3-DEHYDROQUINATE
SYNTHASE

(Acinetobacter
baumannii) 		PF01761
(DHQ_synthase) 		4 THR A  97
LEU A  59
VAL A 161
VAL A 124
 None
 0.96A 4cp4A-5eksA:
undetectable		 4cp4A-5eksA:
21.45
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5epe SAM-DEPENDENT
METHYLTRANSFERASE

(Thiobacillus
denitrificans) 		PF13847
(Methyltransf_31) 		4 LEU A  25
VAL A  40
ASP A  42
VAL A 106
 None
None
SAH  A 301 ( 4.5A)
None
 0.98A 4cp4A-5epeA:
undetectable		 4cp4A-5epeA:
19.86
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5esy SAL1 PHOSPHATASE

(Arabidopsis
thaliana) 		PF00459
(Inositol_P) 		4 THR A 297
LEU A 165
VAL A 327
VAL A 303
 None
 0.94A 4cp4A-5esyA:
undetectable		 4cp4A-5esyA:
23.30
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ffp IMMUNITY 23 FAMILY
PROTEIN

(Burkholderia
dolosa) 		PF15593
(Imm42) 		4 PHE A   9
LEU A 105
VAL A 151
VAL A 148
 None
 0.98A 4cp4A-5ffpA:
undetectable		 4cp4A-5ffpA:
19.07
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5gkx UNCHARACTERIZED
PROTEIN

(Thermococcus
onnurineus) 		PF14336
(DUF4392) 		4 PHE A 142
LEU A 110
VAL A 155
VAL A 114
 None
 0.91A 4cp4A-5gkxA:
undetectable		 4cp4A-5gkxA:
20.43
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5gte LACHRYMATORY-FACTOR
SYNTHASE

(Allium cepa) 		PF10604
(Polyketide_cyc2) 		4 PHE A 104
TYR A 114
LEU A 152
VAL A  73
 None
 0.87A 4cp4A-5gteA:
undetectable		 4cp4A-5gteA:
15.79
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5irb RTX-ADHESIN

(Marinomonas
primoryensis) 		no annotation 4 THR A 446
VAL A 473
ASP A 433
VAL A 435
 None
 0.90A 4cp4A-5irbA:
undetectable		 4cp4A-5irbA:
19.12
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5k8g ANTIFREEZE PROTEIN

(Marinomonas
primoryensis) 		no annotation 4 THR A  56
VAL A  84
ASP A  43
VAL A  45
 None
None
CA  A 615 ( 4.7A)
None
 0.89A 4cp4A-5k8gA:
undetectable		 4cp4A-5k8gA:
21.06
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5lgd PLATELET
GLYCOPROTEIN 4

(Homo sapiens) 		PF01130
(CD36) 		5 PHE A 122
TYR A  93
THR A 130
LEU A 179
VAL A 128
 None
None
NAG  A 507 ( 4.7A)
None
None
 1.45A 4cp4A-5lgdA:
undetectable		 4cp4A-5lgdA:
20.36
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5lop KLLA0A11308P

(Kluyveromyces
lactis) 		no annotation 4 THR C  20
VAL C  43
ASP C  35
VAL C  37
 None
 0.97A 4cp4A-5lopC:
undetectable		 4cp4A-5lopC:
10.65
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5mh5 D-2-HYDROXYACID
DEHYDROGENASE

(Haloferax
mediterranei) 		no annotation 4 THR A  82
VAL A  47
ASP A  45
VAL A  62
 None
 0.87A 4cp4A-5mh5A:
undetectable		 4cp4A-5mh5A:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ue8 PROTEIN UNC-13
HOMOLOG A

(Rattus
norvegicus) 		PF00130
(C1_1)
PF00168
(C2)
PF06292
(DUF1041)
PF10540
(Membr_traf_MHD) 		4 THR A 781
LEU A 788
VAL A 716
VAL A 753
 None
 0.93A 4cp4A-5ue8A:
undetectable		 4cp4A-5ue8A:
17.39
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5wwp ORF1AB

(Middle East
respiratory
syndrome-related
coronavirus) 		no annotation 4 LEU B 438
VAL B 372
ASP B 374
VAL B 397
 None
 0.99A 4cp4A-5wwpB:
undetectable		 4cp4A-5wwpB:
22.11
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5y6n HELICASE DOMAIN FROM
GENOME POLYPROTEIN

(Zika virus) 		no annotation 4 THR A 408
VAL A 423
ASP A 425
VAL A 360
 None
 0.92A 4cp4A-5y6nA:
undetectable		 4cp4A-5y6nA:
undetectable