SIMILAR PATTERNS OF AMINO ACIDS FOR 4CLA_A_CLMA221

List of similar pattern of amino acids derived from ASSAM search

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click link on the last column to view superposed patterns of amino acids in NGL viewer)
(Note that only 3-12 residue patterns can be used for ASSAM searches)
Filter list by:
Hit Macromolecule/
Organism		 Pfam Res. Interface HETATM RMSD Dali Z-score Seq. Identity (%) View Dock
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1cia CHLORAMPHENICOL
ACETYLTRANSFERASE

(Escherichia
coli) 		PF00302
(CAT) 		9 GLN A  92
THR A  94
ALA A 105
LEU A 134
PHE A 135
ASN A 146
VAL A 162
TYR A 168
ILE A 172
 None
None
BME  A 536 ( 4.3A)
None
None
None
None
None
None
 0.22A 4claA-1ciaA:
37.3		 4claA-1ciaA:
99.06
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1dct PROTEIN
(MODIFICATION
METHYLASE HAEIII)

(Haemophilus
influenzae) 		PF00145
(DNA_methylase) 		5 ALA A 313
LEU A  13
PHE A  17
TYR A 169
ILE A 140
 None
 1.15A 4claA-1dctA:
0.4		 4claA-1dctA:
20.36
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ddk IMP-1 METALLO
BETA-LACTAMASE

(Pseudomonas
aeruginosa) 		PF00753
(Lactamase_B) 		5 THR A  96
ALA A 114
LEU A 106
SER A  73
ILE A  47
 None
 1.48A 4claA-1ddkA:
0.0		 4claA-1ddkA:
18.80
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1f8v MATURE CAPSID
PROTEIN BETA

(Pariacoto virus) 		PF01829
(Peptidase_A6) 		5 ALA A 109
LEU A 275
PHE A 117
PHE A 159
ILE A 317
 None
 1.29A 4claA-1f8vA:
0.0		 4claA-1f8vA:
21.88
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1f8w NADH PEROXIDASE

(Enterococcus
faecalis) 		PF02852
(Pyr_redox_dim)
PF07992
(Pyr_redox_2) 		5 ALA A 420
ASN A 433
PHE A 375
VAL A 358
ILE A 434
 None
 1.15A 4claA-1f8wA:
0.0		 4claA-1f8wA:
19.33
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1f8w NADH PEROXIDASE

(Enterococcus
faecalis) 		PF02852
(Pyr_redox_dim)
PF07992
(Pyr_redox_2) 		5 THR A 339
ALA A 389
LEU A 391
PHE A 375
SER A 405
 None
 1.21A 4claA-1f8wA:
0.0		 4claA-1f8wA:
19.33
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1fy1 HEPARIN-BINDING
PROTEIN

(Homo sapiens) 		PF00089
(Trypsin) 		5 ALA A  29
LEU A 108
PHE A  14
PHE A 203
ILE A 170
 None
 1.49A 4claA-1fy1A:
0.0		 4claA-1fy1A:
20.80
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1fy1 HEPARIN-BINDING
PROTEIN

(Homo sapiens) 		PF00089
(Trypsin) 		5 ALA A  29
LEU A 108
PHE A  14
VAL A 146
ILE A 170
 None
 1.10A 4claA-1fy1A:
0.0		 4claA-1fy1A:
20.80
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1gy9 ALPHA-KETOGLUTARATE-
DEPENDENT TAURINE
DIOXYGENASE

(Escherichia
coli) 		PF02668
(TauD) 		5 GLN A  50
ALA A  21
LEU A   5
PHE A  64
ILE A 113
 None
 1.41A 4claA-1gy9A:
0.0		 4claA-1gy9A:
22.15
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1hjq BETA-1,4-GALACTANASE

(Humicola
insolens) 		PF07745
(Glyco_hydro_53) 		5 ALA A 161
LEU A 157
PHE A 201
VAL A 244
ILE A 129
 None
 1.12A 4claA-1hjqA:
0.0		 4claA-1hjqA:
20.12
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1j3u ASPARTASE

(Bacillus sp.
YM55-1) 		PF00206
(Lyase_1)
PF10415
(FumaraseC_C) 		5 GLN A 139
THR A 141
ALA A 144
LEU A  49
ASN A 136
 None
 1.39A 4claA-1j3uA:
undetectable		 4claA-1j3uA:
18.68
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1oed ACETYLCHOLINE
RECEPTOR PROTEIN,
ALPHA CHAIN
ACETYLCHOLINE
RECEPTOR PROTEIN,
GAMMA CHAIN

(Torpedo
marmorata;
Torpedo
marmorata) 		PF02932
(Neur_chan_memb)
PF02932
(Neur_chan_memb) 		5 LEU A 258
PHE E 265
SER E 235
VAL A 232
ILE A 296
 None
 1.41A 4claA-1oedA:
undetectable		 4claA-1oedA:
23.79
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1vp5 2,5-DIKETO-D-GLUCONI
C ACID REDUCTASE

(Thermotoga
maritima) 		PF00248
(Aldo_ket_red) 		5 THR A 214
ALA A 216
PHE A 191
VAL A   3
TYR A  41
 None
NAP  A 300 (-3.1A)
NAP  A 300 (-4.5A)
None
None
 1.26A 4claA-1vp5A:
undetectable		 4claA-1vp5A:
20.71
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1w3i 2-KETO-3-DEOXY
GLUCONATE ALDOLASE

(Sulfolobus
solfataricus) 		PF00701
(DHDPS) 		5 THR A 136
ALA A 100
LEU A 112
TYR A 167
ILE A 158
 None
 1.26A 4claA-1w3iA:
undetectable		 4claA-1w3iA:
21.73
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1wy2 XAA-PRO DIPEPTIDASE

(Pyrococcus
horikoshii) 		PF00557
(Peptidase_M24)
PF01321
(Creatinase_N) 		5 THR A  48
ALA A  22
LEU A  91
SER A  51
ILE A  70
 None
 1.42A 4claA-1wy2A:
undetectable		 4claA-1wy2A:
19.66
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1yw0 TRYPTOPHAN
2,3-DIOXYGENASE

(Xanthomonas
campestris) 		PF03301
(Trp_dioxygenase) 		5 LEU A 226
PHE A 272
SER A  91
VAL A 162
ILE A 134
 None
 1.44A 4claA-1yw0A:
undetectable		 4claA-1yw0A:
21.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1z2i MALATE DEHYDROGENASE

(Agrobacterium
tumefaciens) 		PF02615
(Ldh_2) 		5 THR A  87
ALA A 119
LEU A 251
PHE A 277
SER A  80
 None
 1.20A 4claA-1z2iA:
undetectable		 4claA-1z2iA:
18.33
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2fr1 ERYTHROMYCIN
SYNTHASE, ERYAI

(Saccharopolyspora
erythraea) 		PF08659
(KR) 		5 ALA A1814
LEU A1810
SER A1799
VAL A1889
ILE A1885
 None
 1.43A 4claA-2fr1A:
undetectable		 4claA-2fr1A:
16.27
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2hwk HELICASE NSP2

(Venezuelan
equine
encephalitis
virus) 		PF01707
(Peptidase_C9) 		5 THR A 704
ALA A 707
LEU A 711
SER A 719
VAL A 643
 None
 1.49A 4claA-2hwkA:
undetectable		 4claA-2hwkA:
20.99
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2pgg RNA-DIRECTED RNA
POLYMERASE

(Infectious
bursal disease
virus) 		PF04197
(Birna_RdRp) 		5 GLN A 451
THR A 455
ALA A 454
LEU A 437
PHE A 449
 None
 1.48A 4claA-2pggA:
undetectable		 4claA-2pggA:
14.62
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2v8n LACTOSE PERMEASE

(Escherichia
coli) 		PF01306
(LacY_symp) 		5 THR A 248
ALA A 244
PHE A 162
VAL A 169
ILE A  37
 None
 1.17A 4claA-2v8nA:
undetectable		 4claA-2v8nA:
18.66
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2vyo POLYSACCHARIDE
DEACETYLASE
DOMAIN-CONTAINING
PROTEIN ECU11_0510

(Encephalitozoon
cuniculi) 		PF01522
(Polysacc_deac_1) 		5 ALA A  55
LEU A  48
PHE A 166
VAL A 163
TYR A 157
 None
 1.34A 4claA-2vyoA:
undetectable		 4claA-2vyoA:
19.85
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2w3y VIRULENCE FACTOR

(Pectobacterium
carotovorum) 		no annotation 5 ALA A 126
LEU A 148
PHE A 144
PHE A 219
VAL A 221
 None
PLM  A1278 (-4.2A)
None
PLM  A1278 ( 3.7A)
None
 1.46A 4claA-2w3yA:
undetectable		 4claA-2w3yA:
22.15
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2wl1 PYRIN

(Homo sapiens) 		PF00622
(SPRY)
PF13765
(PRY) 		5 THR A 606
ALA A 607
LEU A 611
VAL A 690
ILE A 674
 None
 1.39A 4claA-2wl1A:
undetectable		 4claA-2wl1A:
17.97
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2zb3 PROSTAGLANDIN
REDUCTASE 2

(Mus musculus) 		PF00107
(ADH_zinc_N)
PF16884
(ADH_N_2) 		5 GLN A 145
LEU A 303
PHE A 229
VAL A 160
ILE A 251
 None
 1.45A 4claA-2zb3A:
undetectable		 4claA-2zb3A:
19.89
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2zb4 PROSTAGLANDIN
REDUCTASE 2

(Homo sapiens) 		PF00107
(ADH_zinc_N)
PF16884
(ADH_N_2) 		5 GLN A 145
LEU A 303
PHE A 229
VAL A 160
ILE A 251
 None
 1.47A 4claA-2zb4A:
undetectable		 4claA-2zb4A:
19.03
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3co1 MICROTUBULE-ASSOCIAT
ED PROTEIN RP/EB
FAMILY MEMBER 3

(Homo sapiens) 		PF00307
(CH) 		5 LEU A  78
PHE A  75
ASN A 104
VAL A  24
ILE A  35
 None
 1.30A 4claA-3co1A:
undetectable		 4claA-3co1A:
16.36
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3d8h GLYCOLYTIC
PHOSPHOGLYCERATE
MUTASE

(Cryptosporidium
parvum) 		PF00300
(His_Phos_1) 		5 THR A  84
ALA A  80
ASN A 100
VAL A 185
ILE A  99
 None
 1.40A 4claA-3d8hA:
undetectable		 4claA-3d8hA:
23.02
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ek5 URIDYLATE KINASE

(Xanthomonas
campestris) 		PF00696
(AA_kinase) 		5 THR A 142
ALA A 146
LEU A 158
VAL A  38
ILE A 130
 None
 1.49A 4claA-3ek5A:
undetectable		 4claA-3ek5A:
20.94
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3f7x PUTATIVE POLYKETIDE
CYCLASE

(Pseudomonas
putida) 		PF12680
(SnoaL_2) 		5 ALA A 104
LEU A  61
PHE A  79
PHE A  49
ILE A  34
 UNL  A 133 (-3.4A)
None
None
UNL  A 134 (-3.3A)
None
 1.33A 4claA-3f7xA:
undetectable		 4claA-3f7xA:
20.91
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3fmf DETHIOBIOTIN
SYNTHETASE

(Mycobacterium
tuberculosis) 		PF13500
(AAA_26) 		5 ALA A 200
LEU A  56
PHE A 208
SER A 170
VAL A   6
 None
 1.32A 4claA-3fmfA:
undetectable		 4claA-3fmfA:
17.51
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3h7r ALDO-KETO REDUCTASE

(Arabidopsis
thaliana) 		PF00248
(Aldo_ket_red) 		5 THR A 234
ALA A 235
LEU A 205
PHE A 278
ILE A 270
 None
NAP  A 401 (-3.2A)
NAP  A 401 (-4.0A)
None
None
 1.40A 4claA-3h7rA:
undetectable		 4claA-3h7rA:
20.36
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3hxw ALANYL-TRNA
SYNTHETASE

(Escherichia
coli) 		PF01411
(tRNA-synt_2c) 		5 THR A  88
ALA A  70
PHE A  38
VAL A 358
ILE A 313
 None
 1.48A 4claA-3hxwA:
undetectable		 4claA-3hxwA:
20.84
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3i0y PUTATIVE POLYKETIDE
CYCLASE

(Xanthomonas
campestris) 		PF12680
(SnoaL_2) 		5 LEU A  32
PHE A  52
ASN A 126
VAL A  72
TYR A  85
 None
None
UNL  A 143 ( 3.3A)
None
UNL  A 143 (-4.7A)
 1.45A 4claA-3i0yA:
undetectable		 4claA-3i0yA:
20.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3jar MICROTUBULE-ASSOCIAT
ED PROTEIN RP/EB
FAMILY MEMBER 3

(Homo sapiens) 		no annotation 5 LEU N  78
PHE N  75
ASN N 104
VAL N  24
ILE N  35
 None
 1.35A 4claA-3jarN:
undetectable		 4claA-3jarN:
20.26
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3keh GLUCOCEREBROSIDASE

(Homo sapiens) 		PF02055
(Glyco_hydro_30)
PF17189
(Glyco_hydro_30C) 		5 THR A 231
ALA A 232
LEU A 264
PHE A 259
SER A 177
 None
 1.49A 4claA-3kehA:
undetectable		 4claA-3kehA:
18.11
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3krb ALDOSE REDUCTASE

(Giardia
intestinalis) 		PF00248
(Aldo_ket_red) 		5 GLN A  85
LEU A 143
PHE A 101
ASN A  76
VAL A 131
 None
 1.44A 4claA-3krbA:
undetectable		 4claA-3krbA:
18.61
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3l88 FIBER PROTEIN

(Human
mastadenovirus
B) 		PF00541
(Adeno_knob) 		5 THR A 191
ALA A 190
PHE A 185
VAL A 172
ILE A 272
 None
 1.41A 4claA-3l88A:
undetectable		 4claA-3l88A:
20.09
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3lml LIN1278 PROTEIN

(Listeria
innocua) 		PF04984
(Phage_sheath_1)
PF17481
(Phage_sheath_1N)
PF17482
(Phage_sheath_1C) 		5 ALA A  26
LEU A 404
ASN A 368
VAL A 432
ILE A 369
 None
 1.43A 4claA-3lmlA:
undetectable		 4claA-3lmlA:
16.95
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3mcw PUTATIVE HYDROLASE

(Chromobacterium
violaceum) 		PF00857
(Isochorismatase) 		5 THR A 129
ALA A 133
LEU A 115
PHE A 138
SER A  96
 None
 1.46A 4claA-3mcwA:
undetectable		 4claA-3mcwA:
18.94
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3n5l BINDING PROTEIN
COMPONENT OF ABC
PHOSPHONATE
TRANSPORTER

(Pseudomonas
aeruginosa) 		PF12974
(Phosphonate-bd) 		5 THR A 107
LEU A 262
PHE A  32
VAL A  62
ILE A  84
 None
 1.10A 4claA-3n5lA:
undetectable		 4claA-3n5lA:
21.45
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3nwa ENVELOPE
GLYCOPROTEIN B

(Human
alphaherpesvirus
1) 		no annotation 5 THR B 394
ALA B 504
PHE B 503
SER B 387
ILE B 450
 None
 1.38A 4claA-3nwaB:
undetectable		 4claA-3nwaB:
13.90
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3o3p MANNOSYL-3-PHOSPHOGL
YCERATE SYNTHASE

(Rubrobacter
xylanophilus) 		PF00535
(Glycos_transf_2) 		5 THR A 126
ALA A 122
LEU A 105
SER A  45
ILE A  77
 None
 1.41A 4claA-3o3pA:
undetectable		 4claA-3o3pA:
20.46
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3q4t ACTIVIN RECEPTOR
TYPE-2A

(Homo sapiens) 		PF00069
(Pkinase) 		5 ALA A 472
LEU A 383
PHE A 341
VAL A 235
ILE A 246
 None
None
None
EDO  A 489 ( 4.8A)
None
 1.40A 4claA-3q4tA:
undetectable		 4claA-3q4tA:
20.61
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3qat MALONYL COA-ACYL
CARRIER PROTEIN
TRANSACYLASE

(Bartonella
henselae) 		PF00698
(Acyl_transf_1) 		5 GLN A  13
THR A  58
ALA A  61
LEU A  95
VAL A 170
 CL  A 316 (-3.5A)
None
None
None
None
 1.32A 4claA-3qatA:
undetectable		 4claA-3qatA:
20.43
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3r6y ASPARTASE

(Bacillus sp.
YM55-1) 		PF00206
(Lyase_1) 		5 GLN A 139
THR A 141
ALA A 144
LEU A  49
ASN A 136
 GLN  A 139 ( 0.6A)
THR  A 141 ( 0.8A)
ALA  A 144 ( 0.0A)
LEU  A  49 ( 0.6A)
ASN  A 136 ( 0.6A)
 1.24A 4claA-3r6yA:
undetectable		 4claA-3r6yA:
20.15
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3syj ADHESION AND
PENETRATION PROTEIN
AUTOTRANSPORTER

(Haemophilus
influenzae) 		PF02395
(Peptidase_S6)
PF03212
(Pertactin) 		5 THR A 151
LEU A  87
PHE A 107
SER A 430
VAL A 124
 None
 1.46A 4claA-3syjA:
undetectable		 4claA-3syjA:
11.78
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3tdw GENTAMICIN
RESISTANCE PROTEIN

(Enterococcus
gallinarum) 		PF01636
(APH) 		5 THR A 143
SER A 225
PHE A 265
VAL A 266
TYR A 233
 None
 1.44A 4claA-3tdwA:
undetectable		 4claA-3tdwA:
19.09
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ugk SACCHAROPINE
DEHYDROGENASE [NAD+,
L-LYSINE-FORMING]

(Saccharomyces
cerevisiae) 		PF05222
(AlaDh_PNT_N) 		5 THR A  25
LEU A   6
PHE A  34
SER A 334
VAL A 352
 None
 1.48A 4claA-3ugkA:
undetectable		 4claA-3ugkA:
18.67
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ulk KETOL-ACID
REDUCTOISOMERASE

(Escherichia
coli) 		PF01450
(IlvC)
PF07991
(IlvN) 		5 THR A 148
ALA A 127
LEU A 101
PHE A 210
ILE A 136
 THR  A 148 ( 0.8A)
ALA  A 127 ( 0.0A)
LEU  A 101 ( 0.6A)
PHE  A 210 ( 1.3A)
ILE  A 136 ( 0.7A)
 1.46A 4claA-3ulkA:
undetectable		 4claA-3ulkA:
17.11
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3vsk PENICILLIN-BINDING
PROTEIN 3

(Staphylococcus
aureus) 		PF00905
(Transpeptidase)
PF03717
(PBP_dimer) 		5 GLN A 404
ALA A 401
LEU A 486
ASN A 581
ILE A 586
 None
 1.14A 4claA-3vskA:
undetectable		 4claA-3vskA:
13.96
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3wfl BETA-MANNANASE

(Talaromyces
trachyspermus) 		PF00150
(Cellulase) 		5 GLN A 325
SER A 288
PHE A 307
TYR A  52
ILE A 333
 None
 1.42A 4claA-3wflA:
undetectable		 4claA-3wflA:
17.77
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3whl PROTEASOME-ACTIVATIN
G NUCLEOTIDASE, 26S
PROTEASE REGULATORY
SUBUNIT 6A

(Pyrococcus
furiosus;
Saccharomyces
cerevisiae) 		PF00004
(AAA) 		5 THR A 276
ALA A 270
LEU A 266
PHE A 267
ILE A 197
 THR  A 276 ( 0.8A)
ALA  A 270 ( 0.0A)
LEU  A 266 ( 0.6A)
PHE  A 267 ( 1.3A)
ILE  A 197 ( 0.7A)
 1.33A 4claA-3whlA:
undetectable		 4claA-3whlA:
19.71
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3wjs NADH OXIDASE

(Gluconobacter
oxydans) 		PF00724
(Oxidored_FMN) 		5 GLN A  77
ALA A  33
LEU A  64
PHE A 166
VAL A 169
 None
 1.34A 4claA-3wjsA:
undetectable		 4claA-3wjsA:
19.67
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4a2b CELL DIVISION
PROTEIN FTSA,
PUTATIVE

(Thermotoga
maritima) 		PF02491
(SHS2_FTSA)
PF14450
(FtsA) 		5 ALA A  36
LEU A  71
SER A  38
VAL A 181
ILE A  13
 None
 1.25A 4claA-4a2bA:
undetectable		 4claA-4a2bA:
19.85
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ay9 FOLLICLE-STIMULATING
HORMONE RECEPTOR

(Homo sapiens) 		PF01462
(LRRNT)
PF12369
(GnHR_trans)
PF13306
(LRR_5) 		5 THR X 130
ALA X 105
LEU X  83
PHE X 116
ILE X 100
 None
 1.33A 4claA-4ay9X:
undetectable		 4claA-4ay9X:
18.29
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ay9 FOLLICLE-STIMULATING
HORMONE RECEPTOR

(Homo sapiens) 		PF01462
(LRRNT)
PF12369
(GnHR_trans)
PF13306
(LRR_5) 		5 THR X 130
ALA X 105
PHE X 116
VAL X  90
ILE X 100
 None
 1.44A 4claA-4ay9X:
undetectable		 4claA-4ay9X:
18.29
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4cg4 PYRIN

(Homo sapiens) 		PF00622
(SPRY)
PF13765
(PRY) 		5 THR A 606
ALA A 607
LEU A 611
VAL A 690
ILE A 674
 None
 1.43A 4claA-4cg4A:
undetectable		 4claA-4cg4A:
20.53
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4cu8 GLYCOSIDE HYDROLASE
2

(Streptococcus
pneumoniae) 		PF00703
(Glyco_hydro_2)
PF02836
(Glyco_hydro_2_C)
PF02837
(Glyco_hydro_2_N)
PF16355
(DUF4982) 		5 ALA A 382
LEU A 384
SER A 335
VAL A 143
TYR A 409
 None
 1.44A 4claA-4cu8A:
undetectable		 4claA-4cu8A:
13.21
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4d1d HYDANTOIN TRANSPORT
PROTEIN

(Microbacterium
liquefaciens) 		PF02133
(Transp_cyt_pur) 		5 THR A 108
ALA A 111
LEU A 115
PHE A 330
VAL A 333
 None
 1.40A 4claA-4d1dA:
undetectable		 4claA-4d1dA:
15.63
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4egs RIBOSE 5-PHOSPHATE
ISOMERASE RPIB

(Caldanaerobacter
subterraneus) 		PF01451
(LMWPc) 		5 THR A 131
ALA A 132
LEU A  55
VAL A   3
ILE A 107
 THR  A 131 ( 0.8A)
ALA  A 132 ( 0.0A)
LEU  A  55 ( 0.6A)
VAL  A   3 ( 0.6A)
ILE  A 107 ( 0.4A)
 1.21A 4claA-4egsA:
undetectable		 4claA-4egsA:
21.24
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4elk HY19.3 TCR BETA
CHAIN (MOUSE
VARIABLE DOMAIN,
HUMAN CONSTANT
DOMAIN)

(Mus musculus) 		PF07654
(C1-set)
PF07686
(V-set) 		5 GLN B  12
THR B 113
LEU B 118
SER B  88
ILE B  80
 None
FMT  B 304 (-3.2A)
None
FMT  B 304 ( 4.4A)
None
 1.44A 4claA-4elkB:
undetectable		 4claA-4elkB:
21.83
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4eyo EXTRACELLULAR
LIGAND-BINDING
RECEPTOR

(Rhodopseudomonas
palustris) 		PF13458
(Peripla_BP_6) 		5 ALA A  45
PHE A 306
VAL A 264
TYR A 381
ILE A 254
 None
 1.40A 4claA-4eyoA:
undetectable		 4claA-4eyoA:
19.51
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4f4p TYROSINE-PROTEIN
KINASE SYK

(Homo sapiens) 		PF07714
(Pkinase_Tyr) 		5 GLN A 477
ALA A 508
LEU A 502
PHE A 566
ILE A 472
 None
 1.30A 4claA-4f4pA:
undetectable		 4claA-4f4pA:
22.14
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4fl3 TYROSINE-PROTEIN
KINASE SYK

(Homo sapiens) 		PF00017
(SH2)
PF07714
(Pkinase_Tyr) 		5 GLN A 477
ALA A 508
LEU A 502
PHE A 566
ILE A 472
 None
 1.34A 4claA-4fl3A:
undetectable		 4claA-4fl3A:
15.40
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4j4x NP PROTEIN

(Sandfly fever
Naples
phlebovirus) 		PF05733
(Tenui_N) 		5 THR A 120
ALA A 123
LEU A 127
SER A 113
VAL A  88
 None
 1.34A 4claA-4j4xA:
undetectable		 4claA-4j4xA:
20.45
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4jde PROTEIN F15E11.1

(Caenorhabditis
elegans) 		no annotation 5 THR B 126
ALA B  14
LEU B 118
VAL B  75
ILE B  55
 None
 1.29A 4claA-4jdeB:
undetectable		 4claA-4jdeB:
18.52
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4lc3 PUTATIVE
UDP-4-AMINO-4-DEOXY-
L-ARABINOSE--OXOGLUT
ARATE
AMINOTRANSFERASE

(Burkholderia
cenocepacia) 		PF01041
(DegT_DnrJ_EryC1) 		5 THR A  83
ALA A 104
LEU A 118
VAL A  74
ILE A  94
 None
 1.42A 4claA-4lc3A:
undetectable		 4claA-4lc3A:
17.88
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4lc9 GLUCOKINASE
REGULATORY PROTEIN

(Rattus
norvegicus) 		no annotation 5 THR A 280
ALA A 276
LEU A 292
VAL A 174
TYR A 134
 None
 1.40A 4claA-4lc9A:
undetectable		 4claA-4lc9A:
16.27
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4lfn GALACTOSE-6-PHOSPHAT
E ISOMERASE SUBUNIT
B

(Lactobacillus
rhamnosus) 		PF02502
(LacAB_rpiB) 		5 GLN B 151
PHE B 158
ASN B  78
VAL B  63
ILE B  81
 None
 1.19A 4claA-4lfnB:
undetectable		 4claA-4lfnB:
20.66
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4m47 DNA POLYMERASE BETA

(Homo sapiens) 		PF10391
(DNA_pol_lambd_f)
PF14716
(HHH_8)
PF14791
(DNA_pol_B_thumb)
PF14792
(DNA_pol_B_palm) 		5 ALA A 175
LEU A 195
PHE A 223
VAL A 221
ILE A 161
 None
 1.25A 4claA-4m47A:
undetectable		 4claA-4m47A:
20.18
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4mck CHITINASE

(Zea mays) 		PF00182
(Glyco_hydro_19) 		5 THR A 136
ALA A 137
PHE A  55
PHE A  23
ILE A  69
 None
 1.17A 4claA-4mckA:
undetectable		 4claA-4mckA:
20.49
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4o5j UNCHARACTERIZED
PROTEIN

(Helicobacter
pylori) 		no annotation 5 ALA A  85
ASN A 352
SER A  80
PHE A  69
VAL A 360
 None
 1.39A 4claA-4o5jA:
undetectable		 4claA-4o5jA:
19.29
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ubq BETA-LACTAMASE

(Acinetobacter
baumannii) 		no annotation 5 ALA A  99
PHE A 119
SER A  83
PHE A 156
ILE A  48
 None
 1.41A 4claA-4ubqA:
undetectable		 4claA-4ubqA:
21.43
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4uis GAMMA-SECRETASE

(Homo sapiens) 		no annotation 5 GLN B 454
THR B 449
ASN B 405
VAL B  97
ILE B 408
 None
 1.32A 4claA-4uisB:
undetectable		 4claA-4uisB:
10.84
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4usr MONOOXYGENASE

(Pseudomonas
stutzeri) 		PF13738
(Pyr_redox_3) 		5 THR A 338
ALA A 339
PHE A  22
PHE A 210
ILE A 333
 None
 1.33A 4claA-4usrA:
undetectable		 4claA-4usrA:
16.16
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4uwq SULFUR OXIDATION
PROTEIN SOXB

(Thermus
thermophilus) 		PF02872
(5_nucleotid_C) 		5 PHE A 470
ASN A 275
SER A 295
VAL A 258
TYR A 198
 None
 1.44A 4claA-4uwqA:
undetectable		 4claA-4uwqA:
15.56
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4wen K88 FIMBRIAL PROTEIN
AC

(Escherichia
coli) 		PF02432
(Fimbrial_K88) 		5 ALA A 132
LEU A 163
SER A 184
VAL A 223
ILE A 190
 None
 1.17A 4claA-4wenA:
undetectable		 4claA-4wenA:
21.30
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4wm0 XYLOSIDE
XYLOSYLTRANSFERASE 1

(Mus musculus) 		PF01501
(Glyco_transf_8) 		5 ALA A 128
LEU A 136
PHE A 130
SER A 123
ILE A 380
 None
 1.07A 4claA-4wm0A:
undetectable		 4claA-4wm0A:
21.52
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4wm0 XYLOSIDE
XYLOSYLTRANSFERASE 1

(Mus musculus) 		PF01501
(Glyco_transf_8) 		5 ALA A 128
LEU A 136
PHE A 130
SER A 123
VAL A 291
 None
 1.18A 4claA-4wm0A:
undetectable		 4claA-4wm0A:
21.52
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4wop ATP-DEPENDENT
DETHIOBIOTIN
SYNTHETASE BIOD

(Mycobacterium
tuberculosis) 		PF13500
(AAA_26) 		5 ALA A 200
LEU A  56
PHE A 208
SER A 170
VAL A   6
 CTP  A 301 (-3.6A)
None
None
CTP  A 301 ( 4.2A)
None
 1.27A 4claA-4wopA:
undetectable		 4claA-4wopA:
17.77
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4xky DIHYDRODIPICOLINATE
SYNTHASE

(Bacteroides
thetaiotaomicron) 		PF00701
(DHDPS) 		5 ALA A 204
PHE A 173
SER A   6
VAL A 104
ILE A   9
 None
 1.03A 4claA-4xkyA:
undetectable		 4claA-4xkyA:
22.70
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ywr PUTATIVE
HYDROXYMETHYLPYRIMID
INE
KINASE/PHOSPHOMETHYL
PYRIMIDINE KINASE

(Acinetobacter
baumannii) 		PF08543
(Phos_pyr_kin) 		5 THR A  46
ALA A  47
PHE A  59
PHE A 133
ILE A  94
 None
 1.13A 4claA-4ywrA:
undetectable		 4claA-4ywrA:
21.43
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4zd6 HALOHYDRIN EPOXIDASE
B

(Corynebacterium
sp.) 		PF13561
(adh_short_C2) 		5 ALA A  63
LEU A  94
PHE A  65
PHE A 105
ILE A  58
 None
 1.46A 4claA-4zd6A:
undetectable		 4claA-4zd6A:
23.95
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5a4j FORMATE--TETRAHYDROF
OLATE LIGASE

(Tepidanaerobacter
acetatoxydans) 		PF01268
(FTHFS) 		5 THR A 236
ALA A 237
PHE A 482
VAL A 485
ILE A 518
 None
 1.15A 4claA-5a4jA:
undetectable		 4claA-5a4jA:
16.64
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5a6b N-ACETYL-BETA-D-GLUC
OSAMINIDASE

(Streptococcus
pneumoniae) 		PF00728
(Glyco_hydro_20) 		5 LEU D  69
SER D   0
PHE D   4
VAL D  31
ILE D  15
 None
 1.31A 4claA-5a6bD:
undetectable		 4claA-5a6bD:
15.65
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5b3r IMP-18

(Pseudomonas
aeruginosa) 		no annotation 5 THR A 114
ALA A 132
LEU A 124
SER A  91
ILE A  65
 None
 1.40A 4claA-5b3rA:
undetectable		 4claA-5b3rA:
22.31
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ey7 FRUCTOKINASE

(Vibrio cholerae) 		PF00294
(PfkB) 		5 THR A 155
ALA A 158
LEU A 139
PHE A 133
SER A 151
 None
 1.08A 4claA-5ey7A:
undetectable		 4claA-5ey7A:
22.19
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5gy0 GLUCANASE

(Ruminiclostridium
thermocellum) 		PF00759
(Glyco_hydro_9)
PF00942
(CBM_3) 		5 THR A 609
LEU A 606
PHE A 580
TYR A 560
ILE A 558
 None
 1.29A 4claA-5gy0A:
undetectable		 4claA-5gy0A:
16.27
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5h7t CLASS IV CHITINASE

(Cryptomeria
japonica) 		no annotation 5 THR A 140
ALA A 141
PHE A  59
PHE A  27
ILE A  73
 None
 1.15A 4claA-5h7tA:
undetectable		 4claA-5h7tA:
20.76
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5hlb PENICILLIN-BINDING
PROTEIN 1B

(Escherichia
coli) 		PF00905
(Transpeptidase)
PF00912
(Transgly)
PF14814
(UB2H) 		5 THR A 232
ALA A 231
LEU A 380
PHE A 327
VAL A 339
 None
 1.00A 4claA-5hlbA:
undetectable		 4claA-5hlbA:
14.54
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5lox PEPTIDASE

(Pseudomonas
aeruginosa) 		no annotation 5 GLN A  47
ALA A   5
LEU A  12
PHE A  14
ILE A 127
 None
 1.25A 4claA-5loxA:
undetectable		 4claA-5loxA:
21.20
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5n4l CERULOPLASMIN

(Rattus
norvegicus) 		no annotation 5 THR A 558
ALA A 557
LEU A 652
ASN A 599
VAL A 432
 None
 1.25A 4claA-5n4lA:
undetectable		 4claA-5n4lA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ntu GROWTH/DIFFERENTIATI
ON FACTOR 8

(Homo sapiens) 		no annotation 5 THR A 240
ALA A 238
LEU A 160
VAL A 208
ILE A 225
 EDO  A 403 (-3.7A)
EDO  A 403 (-4.9A)
None
None
None
 1.48A 4claA-5ntuA:
undetectable		 4claA-5ntuA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5nyw PROTEASOME SUBUNIT

(Yersinia
bercovieri) 		no annotation 5 GLN A  47
ALA A   5
LEU A  12
PHE A  14
ILE A 130
 None
 1.21A 4claA-5nywA:
undetectable		 4claA-5nywA:
20.16
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5v4l ADENYLOSUCCINATE
LYASE

(Cryptococcus
neoformans) 		PF00206
(Lyase_1)
PF10397
(ADSL_C) 		5 THR A  29
LEU A  20
PHE A  21
PHE A 225
TYR A 236
 None
 1.48A 4claA-5v4lA:
1.7		 4claA-5v4lA:
17.78
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5vlj NUCLEAR DISTRIBUTION
PROTEIN PAC1

(Saccharomyces
cerevisiae) 		PF00400
(WD40) 		5 ASN B 490
SER B 149
PHE B 182
VAL B 172
ILE B 152
 None
 1.46A 4claA-5vljB:
undetectable		 4claA-5vljB:
19.44
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5wch PROBABLE UBIQUITIN
CARBOXYL-TERMINAL
HYDROLASE FAF-X

(Homo sapiens) 		no annotation 5 LEU A1647
PHE A1651
SER A1570
PHE A1952
VAL A1792
 None
 1.06A 4claA-5wchA:
undetectable		 4claA-5wchA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5xmb PANTOTHENATE KINASE

(Mycobacterium
tuberculosis) 		no annotation 5 THR A 293
ALA A 292
LEU A 206
PHE A  91
ILE A  60
 None
 1.27A 4claA-5xmbA:
undetectable		 4claA-5xmbA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6a8l -

(-) 		no annotation 5 THR A 140
ALA A 144
LEU A 126
PHE A 149
SER A 107
 None
 1.46A 4claA-6a8lA:
undetectable		 4claA-6a8lA:
undetectable