SIMILAR PATTERNS OF AMINO ACIDS FOR 4CKJ_A_ADNA2014_1

List of similar pattern of amino acids derived from ASSAM search

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click link on the last column to view superposed patterns of amino acids in NGL viewer)
(Note that only 3-12 residue patterns can be used for ASSAM searches)
Filter list by:
Hit Macromolecule/
Organism		 Pfam Res. Interface HETATM RMSD Dali Z-score Seq. Identity (%) View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1gzk RAC-BETA
SERINE/THREONINE
PROTEIN KINASE

(Homo sapiens) 		PF00069
(Pkinase)
PF00433
(Pkinase_C) 		6 LEU A 158
GLY A 159
GLY A 161
VAL A 166
ALA A 179
TYR A 231
 None
 0.50A 4ckjA-1gzkA:
21.8		 4ckjA-1gzkA:
26.02
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1k9a CARBOXYL-TERMINAL
SRC KINASE

(Rattus
norvegicus) 		PF00017
(SH2)
PF00018
(SH3_1)
PF07714
(Pkinase_Tyr) 		7 GLY A 202
GLY A 204
VAL A 209
ALA A 220
TYR A 268
SER A 273
LEU A 321
 None
 0.56A 4ckjA-1k9aA:
35.2		 4ckjA-1k9aA:
26.74
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1py5 TGF-BETA RECEPTOR
TYPE I

(Homo sapiens) 		PF00069
(Pkinase)
PF08515
(TGF_beta_GS) 		6 GLY A 212
VAL A 219
ALA A 230
TYR A 282
SER A 287
LEU A 340
 None
PY1  A 700 ( 4.7A)
PY1  A 700 (-3.5A)
PY1  A 700 (-4.6A)
None
PY1  A 700 (-4.4A)
 0.60A 4ckjA-1py5A:
28.1		 4ckjA-1py5A:
26.06
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1rjb FL CYTOKINE RECEPTOR

(Homo sapiens) 		PF07714
(Pkinase_Tyr) 		7 LEU A 616
GLY A 617
GLY A 619
VAL A 624
ALA A 642
TYR A 693
LEU A 818
 None
 0.55A 4ckjA-1rjbA:
31.5		 4ckjA-1rjbA:
43.06
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1t46 HOMO SAPIENS V-KIT
HARDY-ZUCKERMAN 4
FELINE SARCOMA VIRAL
ONCOGENE HOMOLOG

(Homo sapiens) 		PF07714
(Pkinase_Tyr) 		7 LEU A 595
GLY A 596
GLY A 598
VAL A 603
ALA A 621
TYR A 672
LEU A 799
 STI  A   3 ( 3.8A)
None
None
STI  A   3 ( 4.6A)
STI  A   3 (-3.5A)
STI  A   3 ( 4.0A)
STI  A   3 (-4.4A)
 0.53A 4ckjA-1t46A:
33.8		 4ckjA-1t46A:
45.89
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1u59 TYROSINE-PROTEIN
KINASE ZAP-70

(Homo sapiens) 		PF07714
(Pkinase_Tyr) 		7 LEU A 344
GLY A 345
GLY A 347
VAL A 352
ALA A 367
ALA A 417
LEU A 468
 STU  A 100 (-3.8A)
STU  A 100 (-3.3A)
None
STU  A 100 (-4.8A)
STU  A 100 (-3.2A)
STU  A 100 (-3.7A)
STU  A 100 (-4.5A)
 0.57A 4ckjA-1u59A:
34.6		 4ckjA-1u59A:
34.38
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1u5q SERINE/THREONINE
PROTEIN KINASE TAO2

(Rattus
norvegicus) 		PF00069
(Pkinase) 		7 GLY A  35
GLY A  37
VAL A  42
ALA A  55
TYR A 107
SER A 111
LEU A 158
 None
 0.60A 4ckjA-1u5qA:
27.4		 4ckjA-1u5qA:
27.67
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1zlt SERINE/THREONINE-PRO
TEIN KINASE CHK1

(Homo sapiens) 		PF00069
(Pkinase) 		6 LEU A  15
GLY A  16
VAL A  23
ALA A  36
TYR A  86
LEU A 137
 HYM  A 400 (-4.2A)
HYM  A 400 ( 3.8A)
HYM  A 400 (-4.3A)
HYM  A 400 (-3.5A)
HYM  A 400 (-4.7A)
HYM  A 400 (-4.5A)
 0.50A 4ckjA-1zltA:
24.7		 4ckjA-1zltA:
25.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1zy4 SERINE/THREONINE-PRO
TEIN KINASE GCN2

(Saccharomyces
cerevisiae) 		PF00069
(Pkinase) 		6 LEU A 605
GLY A 606
GLY A 608
VAL A 613
ALA A 626
TYR A 790
 None
None
None
None
GOL  A 998 ( 3.7A)
GOL  A 998 (-4.6A)
 0.47A 4ckjA-1zy4A:
20.6		 4ckjA-1zy4A:
26.47
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2dq7 PROTO-ONCOGENE
TYROSINE-PROTEIN
KINASE FYN

(Homo sapiens) 		PF07714
(Pkinase_Tyr) 		8 LEU X  17
GLY X  18
GLY X  20
VAL X  25
ALA X  37
TYR X  84
SER X  89
LEU X 137
 STU  X 902 (-3.8A)
STU  X 902 ( 3.7A)
None
STU  X 902 ( 4.8A)
STU  X 902 (-3.1A)
STU  X 902 (-4.6A)
STU  X 902 ( 4.0A)
STU  X 902 (-4.4A)
 0.70A 4ckjA-2dq7X:
36.1		 4ckjA-2dq7X:
34.48
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2f9g MITOGEN-ACTIVATED
PROTEIN KINASE FUS3

(Saccharomyces
cerevisiae) 		PF00069
(Pkinase) 		6 LEU A  19
GLY A  20
GLY A  22
VAL A  27
ALA A  40
LEU A 144
 ADP  A 500 (-4.3A)
ADP  A 500 ( 4.1A)
ADP  A 500 ( 4.6A)
ADP  A 500 (-4.3A)
ADP  A 500 ( 3.7A)
ADP  A 500 (-4.3A)
 0.28A 4ckjA-2f9gA:
19.9		 4ckjA-2f9gA:
23.60
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2gcd SERINE/THREONINE-PRO
TEIN KINASE TAO2

(Rattus
norvegicus) 		PF00069
(Pkinase) 		7 GLY A  35
GLY A  37
VAL A  42
ALA A  55
TYR A 107
SER A 111
LEU A 158
 STU  A 400 (-3.3A)
None
STU  A 400 ( 4.8A)
STU  A 400 (-3.2A)
STU  A 400 (-4.5A)
STU  A 400 (-3.3A)
STU  A 400 ( 4.6A)
 0.65A 4ckjA-2gcdA:
28.3		 4ckjA-2gcdA:
27.53
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2h8h PROTO-ONCOGENE
TYROSINE-PROTEIN
KINASE SRC

(Homo sapiens) 		PF00017
(SH2)
PF00018
(SH3_1)
PF07714
(Pkinase_Tyr) 		8 LEU A 273
GLY A 274
GLY A 276
VAL A 281
ALA A 293
TYR A 340
SER A 345
LEU A 393
 H8H  A 534 (-3.8A)
H8H  A 534 ( 3.8A)
None
H8H  A 534 (-4.4A)
H8H  A 534 (-3.2A)
H8H  A 534 (-4.3A)
H8H  A 534 ( 4.5A)
H8H  A 534 (-4.5A)
 0.45A 4ckjA-2h8hA:
30.8		 4ckjA-2h8hA:
24.95
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2hak SERINE/THREONINE-PRO
TEIN KINASE MARK1

(Homo sapiens) 		PF00069
(Pkinase)
PF00627
(UBA) 		6 GLY A  60
GLY A  62
VAL A  67
ALA A  80
TYR A 131
ALA A 132
 None
 0.52A 4ckjA-2hakA:
19.6		 4ckjA-2hakA:
29.08
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2hk5 TYROSINE-PROTEIN
KINASE HCK

(Homo sapiens) 		PF07714
(Pkinase_Tyr) 		7 LEU A 251
GLY A 252
GLY A 254
VAL A 259
ALA A 271
SER A 323
LEU A 371
 1BM  A 499 ( 3.7A)
None
None
1BM  A 499 ( 4.8A)
1BM  A 499 (-3.6A)
None
1BM  A 499 (-4.4A)
 0.55A 4ckjA-2hk5A:
29.0		 4ckjA-2hk5A:
39.74
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2hw6 MAP
KINASE-INTERACTING
SERINE/THREONINE-PRO
TEIN KINASE 1

(Homo sapiens) 		PF00069
(Pkinase) 		6 LEU A  55
GLY A  56
VAL A  63
ALA A  76
SER A 131
LEU A 177
 None
 0.55A 4ckjA-2hw6A:
21.1		 4ckjA-2hw6A:
27.98
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2hz0 PROTO-ONCOGENE
TYROSINE-PROTEIN
KINASE ABL1

(Homo sapiens) 		PF07714
(Pkinase_Tyr) 		6 LEU A 248
GLY A 249
GLY A 251
VAL A 256
ALA A 269
LEU A 370
 GIN  A 600 ( 4.6A)
None
None
GIN  A 600 ( 4.7A)
GIN  A 600 (-3.1A)
GIN  A 600 (-4.7A)
 0.60A 4ckjA-2hz0A:
33.4		 4ckjA-2hz0A:
38.06
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2i0e PROTEIN KINASE
C-BETA II

(Homo sapiens) 		PF00069
(Pkinase)
PF00433
(Pkinase_C) 		6 LEU A 348
GLY A 349
GLY A 351
VAL A 356
ALA A 369
TYR A 422
 PDS  A 901 (-3.9A)
PDS  A 901 ( 3.7A)
None
PDS  A 901 (-4.2A)
PDS  A 901 (-3.3A)
PDS  A 901 (-4.7A)
 0.59A 4ckjA-2i0eA:
18.5		 4ckjA-2i0eA:
24.43
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2iwi SERINE/THREONINE-PRO
TEIN KINASE PIM-2

(Homo sapiens) 		PF00069
(Pkinase) 		6 LEU A  38
GLY A  39
GLY A  41
VAL A  46
ALA A  59
LEU A 170
 HB1  A1289 ( 4.1A)
HB1  A1289 (-3.1A)
None
HB1  A1289 (-3.6A)
HB1  A1289 ( 3.7A)
HB1  A1289 (-4.7A)
 0.60A 4ckjA-2iwiA:
25.1		 4ckjA-2iwiA:
26.48
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2og8 PROTO-ONCOGENE
TYROSINE-PROTEIN
KINASE LCK

(Homo sapiens) 		PF07714
(Pkinase_Tyr) 		6 LEU A 251
GLY A 252
GLY A 254
VAL A 259
ALA A 271
TYR A 318
 None
None
None
None
1N8  A 501 ( 3.4A)
1N8  A 501 ( 3.7A)
 0.53A 4ckjA-2og8A:
31.0		 4ckjA-2og8A:
40.52
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2ogv MACROPHAGE
COLONY-STIMULATING
FACTOR 1 RECEPTOR
PRECURSOR

(Homo sapiens) 		PF07714
(Pkinase_Tyr) 		7 LEU A 588
GLY A 589
GLY A 591
VAL A 596
ALA A 614
TYR A 665
LEU A 785
 None
 0.42A 4ckjA-2ogvA:
31.5		 4ckjA-2ogvA:
43.88
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2ozo TYROSINE-PROTEIN
KINASE ZAP-70

(Homo sapiens) 		PF00017
(SH2)
PF07714
(Pkinase_Tyr) 		6 LEU A 344
GLY A 345
VAL A 352
ALA A 367
ALA A 417
LEU A 468
 ANP  A 615 (-4.4A)
ANP  A 615 ( 4.4A)
ANP  A 615 (-4.5A)
ANP  A 615 (-3.3A)
ANP  A 615 (-3.9A)
ANP  A 615 (-4.7A)
 0.47A 4ckjA-2ozoA:
27.9		 4ckjA-2ozoA:
22.51
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2phk PHOSPHORYLASE KINASE

(Oryctolagus
cuniculus) 		PF00069
(Pkinase) 		6 LEU A  25
GLY A  26
GLY A  28
VAL A  33
ALA A  46
LEU A 156
 ATP  A 381 ( 4.3A)
ATP  A 381 (-3.5A)
ATP  A 381 (-3.0A)
ATP  A 381 (-4.1A)
ATP  A 381 (-3.5A)
ATP  A 381 ( 4.8A)
 0.58A 4ckjA-2phkA:
26.0		 4ckjA-2phkA:
27.41
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2pmo SER/THR PROTEIN
KINASE

(Plasmodium
falciparum) 		PF00069
(Pkinase) 		6 LEU X  34
GLY X  37
ALA X  53
TYR X 119
SER X 124
LEU X 179
 HMD  X 400 ( 4.3A)
None
HMD  X 400 (-3.5A)
HMD  X 400 (-4.5A)
None
HMD  X 400 (-4.7A)
 0.60A 4ckjA-2pmoX:
25.2		 4ckjA-2pmoX:
24.26
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2psq FIBROBLAST GROWTH
FACTOR RECEPTOR 2

(Homo sapiens) 		PF07714
(Pkinase_Tyr) 		7 LEU A 487
GLY A 488
ALA A 515
VAL A 564
TYR A 566
ALA A 567
LEU A 633
 None
 0.72A 4ckjA-2psqA:
38.3		 4ckjA-2psqA:
44.92
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2psq FIBROBLAST GROWTH
FACTOR RECEPTOR 2

(Homo sapiens) 		PF07714
(Pkinase_Tyr) 		7 LEU A 487
VAL A 495
ALA A 515
VAL A 564
TYR A 566
ALA A 567
LEU A 633
 None
 0.38A 4ckjA-2psqA:
38.3		 4ckjA-2psqA:
44.92
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2r4b RECEPTOR
TYROSINE-PROTEIN
KINASE ERBB-4

(Homo sapiens) 		PF07714
(Pkinase_Tyr) 		6 LEU A 724
GLY A 725
GLY A 727
VAL A 732
ALA A 749
LEU A 850
 GW7  A   1 ( 4.2A)
None
None
GW7  A   1 ( 4.8A)
GW7  A   1 (-3.3A)
GW7  A   1 (-4.2A)
 0.40A 4ckjA-2r4bA:
28.4		 4ckjA-2r4bA:
33.24
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2w4o CALCIUM/CALMODULIN-D
EPENDENT PROTEIN
KINASE TYPE IV

(Homo sapiens) 		PF00069
(Pkinase) 		6 LEU A  52
GLY A  53
GLY A  55
VAL A  60
ALA A  73
LEU A 171
 DKI  A1338 (-3.8A)
DKI  A1338 (-3.3A)
None
DKI  A1338 (-4.2A)
DKI  A1338 ( 3.7A)
DKI  A1338 (-4.9A)
 0.61A 4ckjA-2w4oA:
21.3		 4ckjA-2w4oA:
25.75
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2wtk SERINE/THREONINE-PRO
TEIN KINASE 11

(Homo sapiens) 		PF00069
(Pkinase) 		6 LEU C  55
GLY C  56
VAL C  63
ALA C  76
TYR C 131
LEU C 183
 ANP  C   2 ( 4.4A)
ANP  C   2 (-3.3A)
ANP  C   2 (-4.2A)
ANP  C   2 (-3.4A)
None
None
 0.46A 4ckjA-2wtkC:
26.5		 4ckjA-2wtkC:
26.07
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2xyu EPHRIN TYPE-A
RECEPTOR 4,

(Mus musculus) 		PF07714
(Pkinase_Tyr) 		6 GLY A 628
GLY A 630
VAL A 635
ALA A 651
TYR A 701
LEU A 753
 None
None
Q9G  A1898 ( 4.7A)
Q9G  A1898 (-3.2A)
Q9G  A1898 (-4.8A)
Q9G  A1898 (-4.3A)
 0.58A 4ckjA-2xyuA:
28.7		 4ckjA-2xyuA:
34.47
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3b2t FIBROBLAST GROWTH
FACTOR RECEPTOR 2

(Homo sapiens) 		PF07714
(Pkinase_Tyr) 		8 LEU A 487
GLY A 488
VAL A 495
ALA A 515
VAL A 564
TYR A 566
ALA A 567
LEU A 633
 M33  A1996 (-4.0A)
M33  A1996 ( 3.8A)
M33  A1996 ( 4.7A)
M33  A1996 (-3.3A)
None
M33  A1996 ( 4.7A)
M33  A1996 (-3.8A)
M33  A1996 (-4.5A)
 0.40A 4ckjA-3b2tA:
31.8		 4ckjA-3b2tA:
50.79
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3c4f BASIC FIBROBLAST
GROWTH FACTOR
RECEPTOR 1

(Homo sapiens) 		PF07714
(Pkinase_Tyr) 		7 LEU A 484
VAL A 492
ALA A 512
VAL A 561
TYR A 563
ALA A 564
LEU A 630
 C4F  A   1 ( 3.9A)
None
C4F  A   1 (-3.3A)
C4F  A   1 ( 4.8A)
None
C4F  A   1 (-3.5A)
C4F  A   1 (-4.6A)
 0.49A 4ckjA-3c4fA:
27.6		 4ckjA-3c4fA:
51.74
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3d7u TYROSINE-PROTEIN
KINASE CSK

(Homo sapiens) 		PF07714
(Pkinase_Tyr) 		7 GLY A 202
GLY A 204
VAL A 209
ALA A 220
TYR A 268
SER A 273
LEU A 321
 None
 0.55A 4ckjA-3d7uA:
28.3		 4ckjA-3d7uA:
35.33
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3dtc MITOGEN-ACTIVATED
PROTEIN KINASE
KINASE KINASE 9

(Homo sapiens) 		PF07714
(Pkinase_Tyr) 		6 GLY A 151
GLY A 153
VAL A 158
ALA A 169
ALA A 223
LEU A 275
 VIN  A6331 (-3.5A)
SO4  A8001 ( 4.3A)
VIN  A6331 (-4.7A)
VIN  A6331 (-3.4A)
VIN  A6331 (-3.8A)
VIN  A6331 (-4.5A)
 0.51A 4ckjA-3dtcA:
26.8		 4ckjA-3dtcA:
33.13
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3g2f BONE MORPHOGENETIC
PROTEIN RECEPTOR
TYPE-2

(Homo sapiens) 		PF00069
(Pkinase) 		6 GLY A 210
VAL A 217
ALA A 228
TYR A 281
SER A 286
LEU A 340
 ADP  A 900 (-3.4A)
ADP  A 900 (-4.3A)
ADP  A 900 (-3.4A)
None
ADP  A 900 (-3.6A)
ADP  A 900 (-4.6A)
 0.59A 4ckjA-3g2fA:
28.5		 4ckjA-3g2fA:
27.81
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3hng VASCULAR ENDOTHELIAL
GROWTH FACTOR
RECEPTOR 1

(Homo sapiens) 		PF07714
(Pkinase_Tyr) 		8 LEU A 833
GLY A 834
GLY A 836
VAL A 841
ALA A 859
VAL A 909
TYR A 911
LEU A1029
 8ST  A2001 ( 4.7A)
None
None
8ST  A2001 ( 4.6A)
8ST  A2001 ( 3.8A)
8ST  A2001 (-4.1A)
8ST  A2001 (-4.9A)
None
 0.55A 4ckjA-3hngA:
33.0		 4ckjA-3hngA:
42.55
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3lm5 SERINE/THREONINE-PRO
TEIN KINASE 17B

(Homo sapiens) 		PF00069
(Pkinase) 		8 LEU A  39
GLY A  40
GLY A  42
VAL A  47
ALA A  60
TYR A 112
ALA A 113
LEU A 165
 QUE  A   1 ( 3.8A)
None
None
QUE  A   1 ( 4.6A)
QUE  A   1 (-3.2A)
QUE  A   1 (-4.9A)
QUE  A   1 (-3.9A)
None
 0.64A 4ckjA-3lm5A:
26.2		 4ckjA-3lm5A:
25.83
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3mtl CELL DIVISION
PROTEIN KINASE 16

(Homo sapiens) 		PF00069
(Pkinase) 		7 LEU A 171
GLY A 172
GLY A 174
VAL A 179
ALA A 192
TYR A 242
LEU A 293
 FEF  A 668 ( 3.8A)
FEF  A 668 ( 4.2A)
None
FEF  A 668 (-4.9A)
FEF  A 668 (-3.3A)
FEF  A 668 (-4.7A)
FEF  A 668 (-4.2A)
 0.64A 4ckjA-3mtlA:
22.4		 4ckjA-3mtlA:
24.53
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3mvj CAMP-DEPENDENT
PROTEIN KINASE
CATALYTIC SUBUNIT
ALPHA

(Homo sapiens) 		PF00069
(Pkinase) 		7 LEU A  49
GLY A  50
GLY A  52
VAL A  57
ALA A  70
TYR A 122
LEU A 173
 XFE  A 351 (-4.2A)
XFE  A 351 ( 4.0A)
None
XFE  A 351 ( 4.5A)
XFE  A 351 (-3.2A)
None
XFE  A 351 (-4.6A)
 0.64A 4ckjA-3mvjA:
25.7		 4ckjA-3mvjA:
24.82
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3nuu PKB-LIKE

(Homo sapiens) 		PF00069
(Pkinase) 		7 LEU A  88
GLY A  89
VAL A  96
ALA A 109
TYR A 161
ALA A 162
LEU A 212
 JOZ  A 361 (-4.1A)
JOZ  A 361 ( 4.3A)
JOZ  A 361 ( 4.7A)
JOZ  A 361 (-3.4A)
None
JOZ  A 361 (-3.8A)
None
 0.59A 4ckjA-3nuuA:
26.8		 4ckjA-3nuuA:
27.06
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3o96 RAC-ALPHA
SERINE/THREONINE-PRO
TEIN KINASE

(Homo sapiens) 		PF00069
(Pkinase)
PF00169
(PH) 		6 LEU A 156
GLY A 157
GLY A 159
VAL A 164
ALA A 177
TYR A 229
 LEU  A 156 ( 0.6A)
GLY  A 157 ( 0.0A)
GLY  A 159 ( 0.0A)
VAL  A 164 ( 0.6A)
ALA  A 177 ( 0.0A)
TYR  A 229 ( 1.3A)
 0.53A 4ckjA-3o96A:
20.1		 4ckjA-3o96A:
23.42
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3ppz SERINE/THREONINE-PRO
TEIN KINASE CTR1

(Arabidopsis
thaliana) 		PF07714
(Pkinase_Tyr) 		7 GLY A 558
GLY A 560
VAL A 565
ALA A 576
TYR A 627
SER A 632
LEU A 683
 STU  A   1 (-3.2A)
None
STU  A   1 (-4.9A)
STU  A   1 (-3.3A)
STU  A   1 (-4.4A)
STU  A   1 ( 4.3A)
STU  A   1 (-4.3A)
 0.71A 4ckjA-3ppzA:
32.4		 4ckjA-3ppzA:
32.65
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3sxs CYTOPLASMIC
TYROSINE-PROTEIN
KINASE BMX

(Homo sapiens) 		PF07714
(Pkinase_Tyr) 		6 LEU A 423
GLY A 424
VAL A 431
ALA A 443
TYR A 491
LEU A 543
 PP2  A   1 (-4.1A)
PP2  A   1 ( 4.1A)
PP2  A   1 (-4.5A)
PP2  A   1 (-3.2A)
PP2  A   1 ( 4.9A)
PP2  A   1 (-4.6A)
 0.39A 4ckjA-3sxsA:
33.0		 4ckjA-3sxsA:
35.22
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3tt0 BASIC FIBROBLAST
GROWTH FACTOR
RECEPTOR 1

(Homo sapiens) 		PF07714
(Pkinase_Tyr) 		8 LEU A 484
GLY A 485
VAL A 492
ALA A 512
VAL A 561
TYR A 563
ALA A 564
LEU A 630
 07J  A   1 ( 4.3A)
07J  A   1 ( 4.9A)
07J  A   1 (-4.0A)
07J  A   1 (-3.5A)
07J  A   1 (-4.7A)
07J  A   1 (-4.7A)
07J  A   1 (-3.8A)
07J  A   1 ( 4.4A)
 0.51A 4ckjA-3tt0A:
34.2		 4ckjA-3tt0A:
48.84
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3txo PROTEIN KINASE C ETA
TYPE

(Homo sapiens) 		PF00069
(Pkinase)
PF00433
(Pkinase_C) 		6 LEU A 361
GLY A 362
GLY A 364
VAL A 369
ALA A 382
LEU A 486
 07U  A   1 ( 4.8A)
07U  A   1 ( 4.2A)
None
07U  A   1 (-4.8A)
07U  A   1 (-3.3A)
07U  A   1 (-4.3A)
 0.41A 4ckjA-3txoA:
15.9		 4ckjA-3txoA:
25.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ulz BRASSINOSTEROID
INSENSITIVE
1-ASSOCIATED
RECEPTOR KINASE 1

(Arabidopsis
thaliana) 		PF00069
(Pkinase) 		7 LEU A 295
GLY A 296
VAL A 303
ALA A 315
TYR A 365
SER A 370
LEU A 423
 None
 0.76A 4ckjA-3ulzA:
26.3		 4ckjA-3ulzA:
27.20
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3vid VASCULAR ENDOTHELIAL
GROWTH FACTOR
RECEPTOR 2

(Homo sapiens) 		PF07714
(Pkinase_Tyr) 		7 LEU A 840
GLY A 841
GLY A 843
VAL A 848
ALA A 866
VAL A 916
LEU A1035
 4TT  A2001 ( 4.0A)
4TT  A2001 ( 4.8A)
None
4TT  A2001 ( 4.5A)
4TT  A2001 (-3.5A)
None
4TT  A2001 (-4.8A)
 0.43A 4ckjA-3vidA:
32.6		 4ckjA-3vidA:
43.09
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3w18 AURORA KINASE A

(Homo sapiens) 		PF00069
(Pkinase) 		8 LEU A 139
GLY A 140
GLY A 142
VAL A 147
ALA A 160
TYR A 212
ALA A 213
LEU A 263
 N13  A 501 (-3.7A)
None
None
N13  A 501 ( 4.7A)
N13  A 501 ( 4.1A)
N13  A 501 (-4.4A)
N13  A 501 (-3.7A)
N13  A 501 (-4.5A)
 0.57A 4ckjA-3w18A:
22.9		 4ckjA-3w18A:
26.20
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3wig DUAL SPECIFICITY
MITOGEN-ACTIVATED
PROTEIN KINASE
KINASE 1

(Homo sapiens) 		PF00069
(Pkinase) 		6 LEU A  75
GLY A  76
VAL A  83
ALA A  96
SER A 151
LEU A 198
 ANP  A 401 (-3.8A)
ANP  A 401 ( 3.7A)
ANP  A 401 ( 4.3A)
ANP  A 401 (-3.2A)
ANP  A 401 (-3.3A)
ANP  A 401 (-4.8A)
 0.56A 4ckjA-3wigA:
22.3		 4ckjA-3wigA:
26.55
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4af3 AURORA KINASE B

(Homo sapiens) 		PF00069
(Pkinase) 		7 LEU A  83
GLY A  84
VAL A  91
ALA A 104
TYR A 156
ALA A 157
LEU A 207
 VX6  A 500 (-3.8A)
VX6  A 500 ( 4.1A)
VX6  A 500 ( 4.8A)
VX6  A 500 (-3.4A)
VX6  A 500 (-4.2A)
VX6  A 500 (-3.7A)
VX6  A 500 (-4.6A)
 0.59A 4ckjA-4af3A:
20.3		 4ckjA-4af3A:
24.25
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4agd VASCULAR ENDOTHELIAL
GROWTH FACTOR
RECEPTOR 2

(Homo sapiens) 		PF07714
(Pkinase_Tyr) 		7 LEU A 840
GLY A 841
GLY A 843
VAL A 848
ALA A 866
VAL A 916
LEU A1035
 B49  A2000 (-3.7A)
B49  A2000 ( 4.6A)
None
None
B49  A2000 (-3.5A)
B49  A2000 (-4.8A)
B49  A2000 (-4.5A)
 0.42A 4ckjA-4agdA:
32.9		 4ckjA-4agdA:
43.02
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4agu CYCLIN-DEPENDENT
KINASE-LIKE 1

(Homo sapiens) 		PF00069
(Pkinase) 		6 GLY A  11
GLY A  13
VAL A  18
ALA A  31
TYR A  82
LEU A 133
 D15  A 500 (-3.8A)
D15  A 500 (-3.6A)
D15  A 500 (-4.6A)
D15  A 500 (-3.4A)
D15  A 500 (-4.8A)
D15  A 500 (-4.5A)
 0.54A 4ckjA-4aguA:
26.0		 4ckjA-4aguA:
26.56
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4aw2 SERINE/THREONINE-PRO
TEIN KINASE MRCK
ALPHA

(Rattus
norvegicus) 		PF00069
(Pkinase)
PF00433
(Pkinase_C) 		6 GLY A  84
GLY A  86
VAL A  91
ALA A 104
TYR A 156
LEU A 208
 None
None
None
EDO  A1420 (-3.4A)
EDO  A1420 (-4.9A)
EDO  A1420 ( 4.8A)
 0.50A 4ckjA-4aw2A:
24.2		 4ckjA-4aw2A:
23.49
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4c02 ACTIVIN RECEPTOR
TYPE-1

(Homo sapiens) 		PF00069
(Pkinase)
PF08515
(TGF_beta_GS) 		6 GLY A 215
GLY A 217
VAL A 222
ALA A 233
SER A 290
LEU A 343
 None
None
TAK  A1507 (-4.7A)
TAK  A1507 (-3.3A)
None
TAK  A1507 (-4.7A)
 0.40A 4ckjA-4c02A:
28.4		 4ckjA-4c02A:
25.90
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4c0t LIKELY PROTEIN
KINASE

(Candida
albicans) 		PF00069
(Pkinase) 		8 LEU A 246
GLY A 247
GLY A 249
VAL A 254
ALA A 267
TYR A 320
ALA A 321
LEU A 371
 None
 0.56A 4ckjA-4c0tA:
25.3		 4ckjA-4c0tA:
15.26
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4ckr EPITHELIAL DISCOIDIN
DOMAIN-CONTAINING
RECEPTOR 1

(Homo sapiens) 		PF07714
(Pkinase_Tyr) 		6 LEU A 616
GLY A 617
GLY A 619
VAL A 624
ALA A 653
TYR A 703
 None
None
None
DI1  A1000 (-4.8A)
DI1  A1000 (-3.6A)
DI1  A1000 (-4.0A)
 0.54A 4ckjA-4ckrA:
30.1		 4ckjA-4ckrA:
34.62
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4crs SERINE/THREONINE-PRO
TEIN KINASE N2

(Homo sapiens) 		PF00069
(Pkinase)
PF00433
(Pkinase_C) 		6 LEU A 663
VAL A 671
ALA A 684
TYR A 739
ALA A 740
LEU A 789
 AGS  A1985 (-4.2A)
AGS  A1985 (-4.6A)
AGS  A1985 (-3.5A)
None
AGS  A1985 (-3.9A)
AGS  A1985 (-4.8A)
 0.46A 4ckjA-4crsA:
24.7		 4ckjA-4crsA:
26.98
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4f0i HIGH AFFINITY NERVE
GROWTH FACTOR
RECEPTOR

(Homo sapiens) 		PF07714
(Pkinase_Tyr) 		6 LEU A 515
GLY A 516
GLY A 518
VAL A 523
ALA A 541
TYR A 590
 None
 0.51A 4ckjA-4f0iA:
23.6		 4ckjA-4f0iA:
38.94
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4fl3 TYROSINE-PROTEIN
KINASE SYK

(Homo sapiens) 		PF00017
(SH2)
PF07714
(Pkinase_Tyr) 		6 LEU A 377
GLY A 378
VAL A 385
ALA A 400
ALA A 451
LEU A 501
 ANP  A 701 ( 4.6A)
ANP  A 701 ( 4.0A)
ANP  A 701 (-4.1A)
ANP  A 701 (-3.3A)
ANP  A 701 (-4.1A)
ANP  A 701 (-4.5A)
 0.37A 4ckjA-4fl3A:
29.7		 4ckjA-4fl3A:
21.89
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4gl9 TYROSINE-PROTEIN
KINASE

(Mus musculus) 		PF07714
(Pkinase_Tyr) 		7 LEU A 855
GLY A 856
VAL A 863
ALA A 880
TYR A 931
SER A 936
LEU A 983
 IZA  A2001 (-3.7A)
IZA  A2001 ( 4.9A)
None
IZA  A2001 (-3.4A)
None
None
IZA  A2001 ( 4.7A)
 0.52A 4ckjA-4gl9A:
33.4		 4ckjA-4gl9A:
33.23
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4gv1 RAC-ALPHA
SERINE/THREONINE-PRO
TEIN KINASE

(Homo sapiens) 		PF00069
(Pkinase)
PF00433
(Pkinase_C) 		7 LEU A 156
GLY A 157
GLY A 159
VAL A 164
ALA A 177
TYR A 229
ALA A 230
 0XZ  A 501 ( 4.1A)
GOL  A 505 ( 3.4A)
0XZ  A 501 (-4.1A)
0XZ  A 501 (-4.5A)
0XZ  A 501 (-3.3A)
0XZ  A 501 ( 4.9A)
0XZ  A 501 (-3.7A)
 0.32A 4ckjA-4gv1A:
26.2		 4ckjA-4gv1A:
27.01
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4hvi TYROSINE-PROTEIN
KINASE JAK3

(Homo sapiens) 		PF07714
(Pkinase_Tyr) 		7 LEU A 828
GLY A 829
GLY A 831
VAL A 836
ALA A 853
TYR A 904
LEU A 956
 19S  A1201 (-3.9A)
19S  A1201 (-3.7A)
19S  A1201 ( 4.3A)
19S  A1201 (-4.4A)
19S  A1201 (-3.3A)
19S  A1201 (-4.7A)
19S  A1201 (-4.5A)
 0.39A 4ckjA-4hviA:
35.2		 4ckjA-4hviA:
34.83
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4id7 ACTIVATED CDC42
KINASE 1

(Homo sapiens) 		PF07714
(Pkinase_Tyr) 		7 LEU A 132
GLY A 133
VAL A 140
ALA A 156
ALA A 208
SER A 212
LEU A 259
 1G0  A 401 ( 4.5A)
1G0  A 401 ( 4.2A)
1G0  A 401 (-4.4A)
1G0  A 401 (-3.6A)
1G0  A 401 (-3.8A)
1G0  A 401 ( 4.3A)
1G0  A 401 (-4.6A)
 0.52A 4ckjA-4id7A:
34.1		 4ckjA-4id7A:
33.76
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4k11 PROTO-ONCOGENE
TYROSINE-PROTEIN
KINASE SRC

(Homo sapiens) 		PF00017
(SH2)
PF00018
(SH3_1)
PF07714
(Pkinase_Tyr) 		8 LEU A 273
GLY A 274
GLY A 276
VAL A 281
ALA A 293
TYR A 340
SER A 345
LEU A 393
 0J9  A 601 (-4.0A)
0J9  A 601 ( 4.0A)
None
0J9  A 601 (-4.4A)
0J9  A 601 (-3.3A)
0J9  A 601 ( 4.7A)
0J9  A 601 (-4.5A)
0J9  A 601 (-4.5A)
 0.57A 4ckjA-4k11A:
30.3		 4ckjA-4k11A:
26.36
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4k33 FIBROBLAST GROWTH
FACTOR RECEPTOR 3

(Homo sapiens) 		PF07714
(Pkinase_Tyr) 		9 LEU A 478
GLY A 479
GLY A 481
VAL A 486
ALA A 506
VAL A 555
TYR A 557
ALA A 558
LEU A 624
 ACP  A 801 (-3.8A)
ACP  A 801 (-3.4A)
ACP  A 801 (-3.6A)
ACP  A 801 (-4.2A)
ACP  A 801 (-3.3A)
ACP  A 801 (-4.7A)
None
ACP  A 801 (-3.7A)
ACP  A 801 (-4.4A)
 0.47A 4ckjA-4k33A:
32.0		 4ckjA-4k33A:
51.06
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4l52 MITOGEN-ACTIVATED
PROTEIN KINASE
KINASE KINASE 7,
TGF-BETA-ACTIVATED
KINASE 1 AND
MAP3K7-BINDING
PROTEIN 1 CHIMERA

(Homo sapiens) 		PF07714
(Pkinase_Tyr) 		7 GLY A  43
VAL A  50
ALA A  61
TYR A 106
ALA A 107
SER A 111
LEU A 163
 1UL  A 501 ( 4.1A)
1UL  A 501 ( 4.9A)
1UL  A 501 (-3.1A)
1UL  A 501 (-4.1A)
1UL  A 501 (-3.6A)
None
1UL  A 501 (-4.3A)
 0.51A 4ckjA-4l52A:
21.2		 4ckjA-4l52A:
29.81
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4lgg PROTO-ONCOGENE
TYROSINE-PROTEIN
KINASE SRC

(Gallus gallus) 		PF07714
(Pkinase_Tyr) 		8 LEU A 273
GLY A 274
GLY A 276
VAL A 281
ALA A 293
TYR A 340
SER A 345
LEU A 393
 VGG  A 601 (-3.2A)
VGG  A 601 ( 3.8A)
None
VGG  A 601 ( 3.5A)
VGG  A 601 (-3.5A)
VGG  A 601 ( 4.0A)
VGG  A 601 ( 4.4A)
VGG  A 601 (-4.5A)
 0.52A 4ckjA-4lggA:
30.4		 4ckjA-4lggA:
35.10
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4oli NON-RECEPTOR
TYROSINE-PROTEIN
KINASE TYK2

(Homo sapiens) 		PF07714
(Pkinase_Tyr) 		6 LEU A 903
GLY A 904
VAL A 911
ALA A 928
TYR A 980
LEU A1030
 2TT  A1202 (-3.5A)
2TT  A1202 ( 4.2A)
2TT  A1202 (-4.5A)
2TT  A1202 ( 3.9A)
2TT  A1202 (-4.6A)
2TT  A1202 (-4.4A)
 0.46A 4ckjA-4oliA:
31.9		 4ckjA-4oliA:
23.63
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4oli NON-RECEPTOR
TYROSINE-PROTEIN
KINASE TYK2

(Homo sapiens) 		PF07714
(Pkinase_Tyr) 		6 LEU A 903
VAL A 911
ALA A 928
TYR A 980
SER A 985
LEU A1030
 2TT  A1202 (-3.5A)
2TT  A1202 (-4.5A)
2TT  A1202 ( 3.9A)
2TT  A1202 (-4.6A)
None
2TT  A1202 (-4.4A)
 0.48A 4ckjA-4oliA:
31.9		 4ckjA-4oliA:
23.63
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4otd SERINE/THREONINE-PRO
TEIN KINASE N1

(Homo sapiens) 		PF00069
(Pkinase)
PF00433
(Pkinase_C) 		7 LEU A 627
GLY A 628
GLY A 630
VAL A 635
ALA A 648
TYR A 703
LEU A 753
 None
 0.43A 4ckjA-4otdA:
25.3		 4ckjA-4otdA:
26.48
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4q9z HUMAN PROTEIN KINASE
C THETA

(Homo sapiens) 		PF00069
(Pkinase)
PF00433
(Pkinase_C) 		7 LEU A 386
GLY A 387
GLY A 389
VAL A 394
ALA A 407
TYR A 460
LEU A 511
 PZW  A 801 (-3.9A)
PZW  A 801 ( 3.8A)
None
PZW  A 801 (-4.6A)
PZW  A 801 (-3.5A)
None
PZW  A 801 (-4.8A)
 0.48A 4ckjA-4q9zA:
24.6		 4ckjA-4q9zA:
27.93
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ra4 PROTEIN KINASE C

(Homo sapiens) 		PF00069
(Pkinase)
PF00433
(Pkinase_C) 		6 LEU A 345
GLY A 346
GLY A 348
VAL A 353
ALA A 366
TYR A 419
 3KZ  A 701 ( 4.1A)
3KZ  A 701 (-3.3A)
None
3KZ  A 701 (-3.9A)
3KZ  A 701 (-3.4A)
None
 0.43A 4ckjA-4ra4A:
24.9		 4ckjA-4ra4A:
24.62
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4rew 5'-AMP-ACTIVATED
PROTEIN KINASE
CATALYTIC SUBUNIT
ALPHA-1

(Homo sapiens) 		PF00069
(Pkinase)
PF16579
(AdenylateSensor) 		6 LEU A  24
GLY A  25
VAL A  32
ALA A  45
TYR A  97
LEU A 148
 STU  A 601 (-3.7A)
STU  A 601 (-3.5A)
STU  A 601 ( 4.8A)
STU  A 601 (-3.2A)
STU  A 601 (-4.4A)
STU  A 601 (-4.2A)
 0.58A 4ckjA-4rewA:
26.0		 4ckjA-4rewA:
23.03
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4rt7 RECEPTOR-TYPE
TYROSINE-PROTEIN
KINASE FLT3

(Homo sapiens) 		PF07714
(Pkinase_Tyr) 		7 LEU A 616
GLY A 617
GLY A 619
VAL A 624
ALA A 642
TYR A 693
LEU A 818
 P30  A1001 (-3.8A)
None
None
None
P30  A1001 (-3.4A)
P30  A1001 (-4.1A)
P30  A1001 (-4.6A)
 0.48A 4ckjA-4rt7A:
27.2		 4ckjA-4rt7A:
39.21
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4wb7 DNAJ HOMOLOG
SUBFAMILY B MEMBER
1,CAMP-DEPENDENT
PROTEIN KINASE
CATALYTIC SUBUNIT
ALPHA

(Homo sapiens) 		PF00069
(Pkinase)
PF00226
(DnaJ) 		6 LEU A 104
GLY A 105
GLY A 107
VAL A 112
ALA A 125
TYR A 177
 ATP  A 501 ( 4.3A)
ATP  A 501 (-3.5A)
ATP  A 501 (-3.2A)
ATP  A 501 (-4.0A)
ATP  A 501 (-3.4A)
None
 0.58A 4ckjA-4wb7A:
25.6		 4ckjA-4wb7A:
23.36
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4wb7 DNAJ HOMOLOG
SUBFAMILY B MEMBER
1,CAMP-DEPENDENT
PROTEIN KINASE
CATALYTIC SUBUNIT
ALPHA

(Homo sapiens) 		PF00069
(Pkinase)
PF00226
(DnaJ) 		6 LEU A 104
GLY A 105
VAL A 112
ALA A 125
TYR A 177
LEU A 228
 ATP  A 501 ( 4.3A)
ATP  A 501 (-3.5A)
ATP  A 501 (-4.0A)
ATP  A 501 (-3.4A)
None
ATP  A 501 (-4.5A)
 0.51A 4ckjA-4wb7A:
25.6		 4ckjA-4wb7A:
23.36
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4xi2 TYROSINE-PROTEIN
KINASE BTK

(Mus musculus) 		PF00017
(SH2)
PF00018
(SH3_1)
PF07714
(Pkinase_Tyr) 		6 LEU A 408
GLY A 409
VAL A 416
ALA A 428
TYR A 476
LEU A 528
 None
 0.50A 4ckjA-4xi2A:
27.8		 4ckjA-4xi2A:
27.17
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4xuf RECEPTOR-TYPE
TYROSINE-PROTEIN
KINASE FLT3

(Homo sapiens) 		PF07714
(Pkinase_Tyr) 		7 LEU A 616
GLY A 617
GLY A 619
VAL A 624
ALA A 642
TYR A 693
LEU A 818
 P30  A1001 (-4.0A)
None
None
P30  A1001 ( 4.8A)
P30  A1001 (-3.5A)
P30  A1001 ( 4.4A)
P30  A1001 (-4.3A)
 0.42A 4ckjA-4xufA:
23.8		 4ckjA-4xufA:
46.20
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4y93 NON-SPECIFIC
PROTEIN-TYROSINE
KINASE,NON-SPECIFIC
PROTEIN-TYROSINE
KINASE

(Bos taurus) 		PF00169
(PH)
PF00779
(BTK)
PF07714
(Pkinase_Tyr) 		6 LEU A 408
GLY A 409
VAL A 416
ALA A 428
TYR A 476
LEU A 528
 746  A 702 (-3.8A)
746  A 702 ( 3.5A)
746  A 702 ( 4.3A)
746  A 702 (-2.4A)
746  A 702 (-4.4A)
746  A 702 (-4.4A)
 0.49A 4ckjA-4y93A:
30.8		 4ckjA-4y93A:
26.42
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5a46 FIBROBLAST GROWTH
FACTOR RECEPTOR 1
(FMS-RELATED
TYROSINE KINASE 2,
PFEIFFER SYNDROME),
ISOFORM CRA_B

(Homo sapiens) 		PF07714
(Pkinase_Tyr) 		9 LEU A 484
GLY A 485
GLY A 487
VAL A 492
ALA A 512
VAL A 561
TYR A 563
ALA A 564
LEU A 630
 38O  A1769 (-3.2A)
38O  A1769 ( 4.7A)
None
38O  A1769 (-4.5A)
38O  A1769 (-3.6A)
38O  A1769 (-4.3A)
38O  A1769 (-4.2A)
38O  A1769 (-3.9A)
38O  A1769 (-4.6A)
 0.43A 4ckjA-5a46A:
33.9		 4ckjA-5a46A:
44.76
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5es1 MAP/MICROTUBULE
AFFINITY-REGULATING
KINASE 4

(Homo sapiens) 		PF00069
(Pkinase)
PF00627
(UBA) 		6 GLY A  63
GLY A  65
VAL A  70
ALA A  83
TYR A 134
ALA A 135
 5RC  A4000 ( 4.3A)
5RC  A4000 ( 3.9A)
5RC  A4000 (-4.6A)
5RC  A4000 (-3.6A)
5RC  A4000 (-4.5A)
5RC  A4000 (-3.7A)
 0.50A 4ckjA-5es1A:
24.8		 4ckjA-5es1A:
27.25
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5eyk AURORA KINASE B-A

(Xenopus laevis) 		PF00069
(Pkinase) 		6 LEU A  99
GLY A 100
VAL A 107
ALA A 120
ALA A 173
LEU A 223
 5U5  A 401 (-3.8A)
5U5  A 401 (-3.8A)
5U5  A 401 ( 4.3A)
5U5  A 401 (-3.5A)
5U5  A 401 (-3.9A)
5U5  A 401 (-4.7A)
 0.36A 4ckjA-5eykA:
25.9		 4ckjA-5eykA:
24.84
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5f1z NON-RECEPTOR
TYROSINE-PROTEIN
KINASE TYK2

(Homo sapiens) 		PF07714
(Pkinase_Tyr) 		7 LEU A 903
GLY A 904
VAL A 911
ALA A 928
TYR A 980
SER A 985
LEU A1030
 5U3  A1200 (-3.8A)
5U3  A1200 ( 3.7A)
5U3  A1200 ( 4.4A)
5U3  A1200 (-3.5A)
5U3  A1200 (-4.5A)
None
5U3  A1200 (-4.4A)
 0.41A 4ckjA-5f1zA:
32.7		 4ckjA-5f1zA:
34.63
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5fm2 PROTO-ONCOGENE
TYROSINE-PROTEIN
KINASE RECEPTOR RET

(Homo sapiens) 		PF07714
(Pkinase_Tyr) 		10 LEU A 730
GLY A 731
GLY A 733
VAL A 738
ALA A 756
VAL A 804
TYR A 806
ALA A 807
SER A 811
LEU A 881
 PP1  A2012 (-4.6A)
PP1  A2012 ( 3.9A)
None
PP1  A2012 (-4.4A)
PP1  A2012 (-3.2A)
PP1  A2012 (-4.5A)
None
PP1  A2012 ( 3.5A)
PP1  A2012 ( 4.7A)
PP1  A2012 (-4.6A)
 0.52A 4ckjA-5fm2A:
40.5		 4ckjA-5fm2A:
87.89
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5grn PLATELET-DERIVED
GROWTH FACTOR
RECEPTOR ALPHA

(Homo sapiens) 		PF07714
(Pkinase_Tyr) 		7 LEU A 599
GLY A 600
GLY A 602
VAL A 607
ALA A 625
TYR A 676
LEU A 825
 748  A1001 (-3.8A)
None
None
748  A1001 ( 4.7A)
748  A1001 (-3.7A)
748  A1001 (-4.0A)
748  A1001 (-4.3A)
 0.53A 4ckjA-5grnA:
25.4		 4ckjA-5grnA:
43.09
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5gza PROTEIN O-MANNOSE
KINASE

(Danio rerio) 		PF07714
(Pkinase_Tyr) 		7 GLY A  86
GLY A  88
VAL A  93
ALA A 104
TYR A 149
SER A 154
LEU A 214
 ADP  A 401 (-3.6A)
ADP  A 401 (-3.1A)
ADP  A 401 (-4.4A)
ADP  A 401 (-3.2A)
ADP  A 401 ( 4.8A)
ADP  A 401 ( 4.2A)
ADP  A 401 (-4.4A)
 0.73A 4ckjA-5gzaA:
22.1		 4ckjA-5gzaA:
23.19
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5iso 5'-AMP-ACTIVATED
PROTEIN KINASE
CATALYTIC SUBUNIT
ALPHA-2

(Homo sapiens) 		PF00069
(Pkinase)
PF16579
(AdenylateSensor) 		6 LEU A  22
GLY A  23
VAL A  30
ALA A  43
TYR A  95
LEU A 146
 STU  A 601 (-4.1A)
STU  A 601 (-3.4A)
STU  A 601 (-4.8A)
STU  A 601 (-3.3A)
STU  A 601 (-4.3A)
STU  A 601 (-4.5A)
 0.53A 4ckjA-5isoA:
25.5		 4ckjA-5isoA:
20.07
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5kbr SERINE/THREONINE-PRO
TEIN KINASE PAK 1

(Homo sapiens) 		PF00069
(Pkinase) 		6 GLY A 277
VAL A 284
ALA A 297
TYR A 346
SER A 351
LEU A 396
 IPW  A 601 ( 3.9A)
IPW  A 601 (-4.2A)
IPW  A 601 (-3.5A)
IPW  A 601 (-4.5A)
None
IPW  A 601 (-4.5A)
 0.51A 4ckjA-5kbrA:
13.3		 4ckjA-5kbrA:
24.32
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5u94 SERINE/THREONINE-PRO
TEIN KINASE PKNB

(Mycobacterium
tuberculosis) 		no annotation 6 LEU A  17
GLY A  18
GLY A  20
VAL A  25
ALA A  38
TYR A  94
 G93  A 301 ( 3.8A)
G93  A 301 ( 3.2A)
None
G93  A 301 (-3.4A)
G93  A 301 ( 3.7A)
None
 0.21A 4ckjA-5u94A:
22.1		 4ckjA-5u94A:
14.33
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5w5j RECEPTOR-INTERACTING
SERINE/THREONINE-PRO
TEIN KINASE 2

(Homo sapiens) 		no annotation 6 LEU A  24
VAL A  32
ALA A  45
TYR A  97
SER A 102
LEU A 153
 9WS  A 401 ( 4.2A)
9WS  A 401 ( 4.6A)
9WS  A 401 (-3.3A)
None
None
9WS  A 401 (-4.6A)
 0.49A 4ckjA-5w5jA:
23.8		 4ckjA-5w5jA:
28.15
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5wnm RECEPTOR-INTERACTING
SERINE/THREONINE-PRO
TEIN KINASE 4

(Mus musculus) 		no annotation 6 GLY A  29
VAL A  36
ALA A  49
TYR A  98
SER A 103
LEU A 150
 VX6  A 402 ( 4.2A)
VX6  A 402 (-4.6A)
VX6  A 402 (-3.2A)
VX6  A 402 (-4.3A)
VX6  A 402 ( 4.7A)
VX6  A 402 (-4.4A)
 0.55A 4ckjA-5wnmA:
28.7		 4ckjA-5wnmA:
14.65
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5wno RECEPTOR
TYROSINE-PROTEIN
KINASE LET-23

(Caenorhabditis
elegans) 		no annotation 6 LEU A 891
GLY A 892
VAL A 899
ALA A 917
TYR A 965
LEU A1017
 ANP  A1201 (-4.1A)
ANP  A1201 ( 3.8A)
ANP  A1201 (-4.4A)
ANP  A1201 (-3.3A)
ANP  A1201 (-4.4A)
ANP  A1201 (-4.7A)
 0.58A 4ckjA-5wnoA:
27.7		 4ckjA-5wnoA:
15.73
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6ao5 SERINE/THREONINE-PRO
TEIN KINASE 3

(Homo sapiens) 		no annotation 7 LEU A  33
GLY A  34
GLY A  36
VAL A  41
ALA A  54
TYR A 101
LEU A 153
 ANP  A 501 ( 3.8A)
ANP  A 501 ( 3.9A)
None
ANP  A 501 (-4.4A)
ANP  A 501 ( 3.7A)
ANP  A 501 ( 4.2A)
ANP  A 501 (-4.6A)
 0.94A 4ckjA-6ao5A:
22.4		 4ckjA-6ao5A:
25.93
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6c7y TYROSINE-PROTEIN
KINASE JAK1

(Homo sapiens) 		no annotation 6 LEU A 881
GLY A 882
VAL A 889
ALA A 906
SER A 963
LEU A1010
 ADP  A1201 ( 4.5A)
ADP  A1201 (-3.5A)
ADP  A1201 (-4.3A)
ADP  A1201 (-3.4A)
ADP  A1201 (-3.3A)
ADP  A1201 (-4.5A)
 0.50A 4ckjA-6c7yA:
27.6		 4ckjA-6c7yA:
14.05
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6c9d SERINE/THREONINE-PRO
TEIN KINASE
MARK1,SERINE/THREONI
NE-PROTEIN KINASE
MARK1

(Homo sapiens) 		no annotation 7 GLY A  67
GLY A  69
VAL A  74
ALA A  87
TYR A 138
ALA A 139
LEU A 189
 None
 0.73A 4ckjA-6c9dA:
26.1		 4ckjA-6c9dA:
14.18
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6f3d INTERLEUKIN-1
RECEPTOR-ASSOCIATED
KINASE 4

(Homo sapiens) 		no annotation 7 GLY A 193
GLY A 195
VAL A 200
ALA A 211
TYR A 264
SER A 269
LEU A 318
 CJT  A 502 ( 3.9A)
None
CJT  A 502 ( 4.8A)
CJT  A 502 (-3.4A)
CJT  A 502 (-4.5A)
CJT  A 502 ( 4.3A)
CJT  A 502 (-4.7A)
 0.77A 4ckjA-6f3dA:
27.1		 4ckjA-6f3dA:
14.34
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
6fek PROTO-ONCOGENE
TYROSINE-PROTEIN
KINASE RECEPTOR RET

(Homo sapiens) 		no annotation 9 LEU A 730
GLY A 731
VAL A 738
ALA A 756
VAL A 804
TYR A 806
ALA A 807
SER A 811
LEU A 881
 ADN  A1104 ( 4.0A)
ADN  A1104 ( 3.9A)
ADN  A1104 (-4.4A)
ADN  A1104 (-3.4A)
ADN  A1104 ( 4.6A)
ADN  A1104 ( 4.1A)
ADN  A1104 (-3.6A)
ADN  A1104 (-3.7A)
ADN  A1104 (-4.3A)
 0.18A 4ckjA-6fekA:
44.9		 4ckjA-6fekA:
97.50
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6fyo DUAL SPECIFICITY
PROTEIN KINASE CLK1

(Homo sapiens) 		no annotation 6 LEU A 167
GLY A 168
GLY A 170
VAL A 175
ALA A 189
LEU A 295
 EAQ  A 501 (-3.9A)
None
None
None
EAQ  A 501 (-3.6A)
EAQ  A 501 (-4.9A)
 0.37A 4ckjA-6fyoA:
25.7		 4ckjA-6fyoA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6fyo DUAL SPECIFICITY
PROTEIN KINASE CLK1

(Homo sapiens) 		no annotation 6 LEU A 167
GLY A 168
GLY A 170
VAL A 175
ALA A 189
SER A 247
 EAQ  A 501 (-3.9A)
None
None
None
EAQ  A 501 (-3.6A)
None
 0.38A 4ckjA-6fyoA:
25.7		 4ckjA-6fyoA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6fyv DUAL SPECIFICITY
PROTEIN KINASE CLK4

(Homo sapiens) 		no annotation 6 LEU A 167
GLY A 168
GLY A 170
VAL A 175
ALA A 189
SER A 247
 3NG  A 501 (-3.9A)
3NG  A 501 (-3.5A)
3NG  A 501 ( 4.9A)
3NG  A 501 ( 4.3A)
3NG  A 501 (-3.5A)
None
 0.41A 4ckjA-6fyvA:
24.8		 4ckjA-6fyvA:
undetectable