SIMILAR PATTERNS OF AMINO ACIDS FOR 4CKI_A_ADNA2022

List of similar pattern of amino acids derived from ASSAM search

Hit pattern: 3D amino acid arrangements similar to known drug binding site

Query pattern: Residues from known binding site for annotated drug that match the hit pattern


(Click link on the last column to view superposed patterns of amino acids in NGL viewer)
(Note that only 3-12 residue patterns can be used for ASSAM searches)
Filter list by:
Hit Macromolecule/
Organism
Pfam Res. Interface HETATM RMSD Dali Z-score Seq. Identity (%) View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1fot CAMP-DEPENDENT
PROTEIN KINASE TYPE
1


(Saccharomyces
cerevisiae)
PF00069
(Pkinase)
6 LEU A  93
GLY A  94
GLY A  96
VAL A 101
ALA A 114
TYR A 166
None
0.62A 4ckiA-1fotA:
24.0
4ckiA-1fotA:
24.40
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1k2p TYROSINE-PROTEIN
KINASE BTK


(Homo sapiens)
PF07714
(Pkinase_Tyr)
6 GLY A 411
VAL A 416
ALA A 428
TYR A 476
GLY A 480
LEU A 528
None
0.66A 4ckiA-1k2pA:
28.1
4ckiA-1k2pA:
35.06
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1k2p TYROSINE-PROTEIN
KINASE BTK


(Homo sapiens)
PF07714
(Pkinase_Tyr)
6 LEU A 408
GLY A 411
VAL A 416
TYR A 476
GLY A 480
LEU A 528
None
0.88A 4ckiA-1k2pA:
28.1
4ckiA-1k2pA:
35.06
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1k9a CARBOXYL-TERMINAL
SRC KINASE


(Rattus
norvegicus)
PF00017
(SH2)
PF00018
(SH3_1)
PF07714
(Pkinase_Tyr)
7 GLY A 202
VAL A 209
ALA A 220
TYR A 268
GLY A 272
SER A 273
LEU A 321
None
0.38A 4ckiA-1k9aA:
35.1
4ckiA-1k9aA:
26.95
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1luf MUSCLE-SPECIFIC
TYROSINE KINASE
RECEPTOR MUSK


(Rattus
norvegicus)
PF07714
(Pkinase_Tyr)
6 GLY A 581
VAL A 588
ALA A 606
TYR A 656
GLY A 660
LEU A 731
None
0.74A 4ckiA-1lufA:
26.8
4ckiA-1lufA:
37.43
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1py5 TGF-BETA RECEPTOR
TYPE I


(Homo sapiens)
PF00069
(Pkinase)
PF08515
(TGF_beta_GS)
8 GLY A 212
GLY A 214
VAL A 219
ALA A 230
TYR A 282
GLY A 286
SER A 287
LEU A 340
None
None
PY1  A 700 ( 4.7A)
PY1  A 700 (-3.5A)
PY1  A 700 (-4.6A)
PY1  A 700 (-3.6A)
None
PY1  A 700 (-4.4A)
0.71A 4ckiA-1py5A:
28.3
4ckiA-1py5A:
25.78
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1rjb FL CYTOKINE RECEPTOR

(Homo sapiens)
PF07714
(Pkinase_Tyr)
7 LEU A 616
GLY A 617
VAL A 624
ALA A 642
TYR A 693
GLY A 697
LEU A 818
None
0.51A 4ckiA-1rjbA:
30.8
4ckiA-1rjbA:
42.77
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1rjb FL CYTOKINE RECEPTOR

(Homo sapiens)
PF07714
(Pkinase_Tyr)
6 LEU A 616
GLY A 831
ALA A 642
TYR A 693
GLY A 697
LEU A 818
None
0.67A 4ckiA-1rjbA:
30.8
4ckiA-1rjbA:
42.77
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1s9i DUAL SPECIFICITY
MITOGEN-ACTIVATED
PROTEIN KINASE
KINASE 2


(Homo sapiens)
PF00069
(Pkinase)
7 LEU A  78
GLY A  79
VAL A  86
ALA A  99
GLY A 153
SER A 154
LEU A 201
ATP  A 535 (-3.9A)
ATP  A 535 ( 3.9A)
ATP  A 535 (-4.1A)
ATP  A 535 (-3.6A)
ATP  A 535 ( 4.7A)
ATP  A 535 (-2.6A)
ATP  A 535 (-4.8A)
0.57A 4ckiA-1s9iA:
17.0
4ckiA-1s9iA:
26.26
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1t46 HOMO SAPIENS V-KIT
HARDY-ZUCKERMAN 4
FELINE SARCOMA VIRAL
ONCOGENE HOMOLOG


(Homo sapiens)
PF07714
(Pkinase_Tyr)
7 LEU A 595
GLY A 596
VAL A 603
ALA A 621
TYR A 672
GLY A 676
LEU A 799
STI  A   3 ( 3.8A)
None
STI  A   3 ( 4.6A)
STI  A   3 (-3.5A)
STI  A   3 ( 4.0A)
STI  A   3 ( 3.8A)
STI  A   3 (-4.4A)
0.51A 4ckiA-1t46A:
33.1
4ckiA-1t46A:
45.57
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1u59 TYROSINE-PROTEIN
KINASE ZAP-70


(Homo sapiens)
PF07714
(Pkinase_Tyr)
7 LEU A 344
GLY A 345
VAL A 352
ALA A 367
ALA A 417
GLY A 420
LEU A 468
STU  A 100 (-3.8A)
STU  A 100 (-3.3A)
STU  A 100 (-4.8A)
STU  A 100 (-3.2A)
STU  A 100 (-3.7A)
STU  A 100 (-3.5A)
STU  A 100 (-4.5A)
0.58A 4ckiA-1u59A:
34.0
4ckiA-1u59A:
34.38
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1u5q SERINE/THREONINE
PROTEIN KINASE TAO2


(Rattus
norvegicus)
PF00069
(Pkinase)
7 GLY A  35
VAL A  42
ALA A  55
TYR A 107
GLY A 110
SER A 111
LEU A 158
None
0.55A 4ckiA-1u5qA:
27.3
4ckiA-1u5qA:
26.24
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ua2 CELL DIVISION
PROTEIN KINASE 7


(Homo sapiens)
PF00069
(Pkinase)
6 LEU A  18
GLY A  19
GLY A  21
VAL A  26
ALA A  39
LEU A 144
ATP  A 381 (-4.4A)
ATP  A 381 ( 3.9A)
TPO  A 170 (-3.1A)
ATP  A 381 (-4.0A)
ATP  A 381 (-3.6A)
None
0.72A 4ckiA-1ua2A:
21.7
4ckiA-1ua2A:
24.56
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1zlt SERINE/THREONINE-PRO
TEIN KINASE CHK1


(Homo sapiens)
PF00069
(Pkinase)
8 LEU A  15
GLY A  16
GLY A  18
VAL A  23
ALA A  36
TYR A  86
GLY A  90
LEU A 137
HYM  A 400 (-4.2A)
HYM  A 400 ( 3.8A)
HYM  A 400 ( 3.7A)
HYM  A 400 (-4.3A)
HYM  A 400 (-3.5A)
HYM  A 400 (-4.7A)
None
HYM  A 400 (-4.5A)
0.74A 4ckiA-1zltA:
25.6
4ckiA-1zltA:
25.22
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2dq7 PROTO-ONCOGENE
TYROSINE-PROTEIN
KINASE FYN


(Homo sapiens)
PF07714
(Pkinase_Tyr)
8 LEU X  17
GLY X  18
VAL X  25
ALA X  37
TYR X  84
GLY X  88
SER X  89
LEU X 137
STU  X 902 (-3.8A)
STU  X 902 ( 3.7A)
STU  X 902 ( 4.8A)
STU  X 902 (-3.1A)
STU  X 902 (-4.6A)
STU  X 902 (-3.5A)
STU  X 902 ( 4.0A)
STU  X 902 (-4.4A)
0.57A 4ckiA-2dq7X:
35.7
4ckiA-2dq7X:
34.80
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2gcd SERINE/THREONINE-PRO
TEIN KINASE TAO2


(Rattus
norvegicus)
PF00069
(Pkinase)
7 GLY A  35
VAL A  42
ALA A  55
TYR A 107
GLY A 110
SER A 111
LEU A 158
STU  A 400 (-3.3A)
STU  A 400 ( 4.8A)
STU  A 400 (-3.2A)
STU  A 400 (-4.5A)
STU  A 400 (-3.4A)
STU  A 400 (-3.3A)
STU  A 400 ( 4.6A)
0.59A 4ckiA-2gcdA:
28.2
4ckiA-2gcdA:
26.06
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2h8h PROTO-ONCOGENE
TYROSINE-PROTEIN
KINASE SRC


(Homo sapiens)
PF00017
(SH2)
PF00018
(SH3_1)
PF07714
(Pkinase_Tyr)
8 LEU A 273
GLY A 274
VAL A 281
ALA A 293
TYR A 340
GLY A 344
SER A 345
LEU A 393
H8H  A 534 (-3.8A)
H8H  A 534 ( 3.8A)
H8H  A 534 (-4.4A)
H8H  A 534 (-3.2A)
H8H  A 534 (-4.3A)
H8H  A 534 (-3.3A)
H8H  A 534 ( 4.5A)
H8H  A 534 (-4.5A)
0.36A 4ckiA-2h8hA:
30.4
4ckiA-2h8hA:
25.14
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2hck HEMATOPOETIC CELL
KINASE HCK


(Homo sapiens)
PF00017
(SH2)
PF00018
(SH3_1)
PF07714
(Pkinase_Tyr)
7 LEU A 273
GLY A 274
GLY A 276
VAL A 281
ALA A 293
GLY A 344
SER A 345
QUE  A   1 (-3.9A)
QUE  A   1 ( 4.2A)
None
QUE  A   1 ( 4.8A)
QUE  A   1 (-3.5A)
QUE  A   1 (-3.0A)
QUE  A   1 ( 4.7A)
0.73A 4ckiA-2hckA:
30.1
4ckiA-2hckA:
33.86
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2hck HEMATOPOETIC CELL
KINASE HCK


(Homo sapiens)
PF00017
(SH2)
PF00018
(SH3_1)
PF07714
(Pkinase_Tyr)
7 LEU A 273
GLY A 274
VAL A 281
ALA A 293
GLY A 344
SER A 345
LEU A 393
QUE  A   1 (-3.9A)
QUE  A   1 ( 4.2A)
QUE  A   1 ( 4.8A)
QUE  A   1 (-3.5A)
QUE  A   1 (-3.0A)
QUE  A   1 ( 4.7A)
QUE  A   1 (-4.4A)
0.46A 4ckiA-2hckA:
30.1
4ckiA-2hckA:
33.86
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2hen EPHRIN TYPE-B
RECEPTOR 2


(Mus musculus)
PF07714
(Pkinase_Tyr)
7 GLY A 636
GLY A 638
VAL A 643
ALA A 659
GLY A 713
SER A 714
LEU A 761
ADP  A 400 ( 3.9A)
ADP  A 400 ( 4.0A)
ADP  A 400 ( 4.4A)
ADP  A 400 (-3.2A)
ADP  A 400 ( 4.2A)
ADP  A 400 (-3.1A)
ADP  A 400 ( 4.7A)
0.88A 4ckiA-2henA:
26.8
4ckiA-2henA:
34.06
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2hk5 TYROSINE-PROTEIN
KINASE HCK


(Homo sapiens)
PF07714
(Pkinase_Tyr)
7 LEU A 251
GLY A 252
VAL A 259
ALA A 271
GLY A 322
SER A 323
LEU A 371
1BM  A 499 ( 3.7A)
None
1BM  A 499 ( 4.8A)
1BM  A 499 (-3.6A)
1BM  A 499 (-3.5A)
None
1BM  A 499 (-4.4A)
0.49A 4ckiA-2hk5A:
30.3
4ckiA-2hk5A:
40.07
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2hw6 MAP
KINASE-INTERACTING
SERINE/THREONINE-PRO
TEIN KINASE 1


(Homo sapiens)
PF00069
(Pkinase)
7 LEU A  55
GLY A  56
VAL A  63
ALA A  76
GLY A 130
SER A 131
LEU A 177
None
0.47A 4ckiA-2hw6A:
20.4
4ckiA-2hw6A:
28.28
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2hz0 PROTO-ONCOGENE
TYROSINE-PROTEIN
KINASE ABL1


(Homo sapiens)
PF07714
(Pkinase_Tyr)
6 LEU A 248
GLY A 249
GLY A 383
VAL A 256
ALA A 269
LEU A 370
GIN  A 600 ( 4.6A)
None
None
GIN  A 600 ( 4.7A)
GIN  A 600 (-3.1A)
GIN  A 600 (-4.7A)
0.79A 4ckiA-2hz0A:
33.5
4ckiA-2hz0A:
38.39
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2hz0 PROTO-ONCOGENE
TYROSINE-PROTEIN
KINASE ABL1


(Homo sapiens)
PF07714
(Pkinase_Tyr)
6 LEU A 248
GLY A 249
VAL A 256
ALA A 269
GLY A 321
LEU A 370
GIN  A 600 ( 4.6A)
None
GIN  A 600 ( 4.7A)
GIN  A 600 (-3.1A)
None
GIN  A 600 (-4.7A)
0.39A 4ckiA-2hz0A:
33.5
4ckiA-2hz0A:
38.39
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2og8 PROTO-ONCOGENE
TYROSINE-PROTEIN
KINASE LCK


(Homo sapiens)
PF07714
(Pkinase_Tyr)
6 LEU A 251
ALA A 271
TYR A 318
GLY A 322
SER A 323
LEU A 371
None
1N8  A 501 ( 3.4A)
1N8  A 501 ( 3.7A)
1N8  A 501 ( 3.5A)
None
1N8  A 501 ( 4.3A)
0.66A 4ckiA-2og8A:
30.2
4ckiA-2og8A:
40.85
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2ogv MACROPHAGE
COLONY-STIMULATING
FACTOR 1 RECEPTOR
PRECURSOR


(Homo sapiens)
PF07714
(Pkinase_Tyr)
7 LEU A 588
GLY A 589
VAL A 596
ALA A 614
TYR A 665
GLY A 669
LEU A 785
None
0.43A 4ckiA-2ogvA:
30.8
4ckiA-2ogvA:
43.58
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2ozo TYROSINE-PROTEIN
KINASE ZAP-70


(Homo sapiens)
PF00017
(SH2)
PF07714
(Pkinase_Tyr)
8 LEU A 344
GLY A 345
GLY A 347
VAL A 352
ALA A 367
ALA A 417
GLY A 420
LEU A 468
ANP  A 615 (-4.4A)
ANP  A 615 ( 4.4A)
ANP  A 615 (-3.6A)
ANP  A 615 (-4.5A)
ANP  A 615 (-3.3A)
ANP  A 615 (-3.9A)
ANP  A 615 ( 3.9A)
ANP  A 615 (-4.7A)
0.77A 4ckiA-2ozoA:
24.0
4ckiA-2ozoA:
22.51
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2ozo TYROSINE-PROTEIN
KINASE ZAP-70


(Homo sapiens)
PF00017
(SH2)
PF07714
(Pkinase_Tyr)
7 LEU A 344
GLY A 345
VAL A 352
ALA A 367
ALA A 417
GLY A 418
LEU A 468
ANP  A 615 (-4.4A)
ANP  A 615 ( 4.4A)
ANP  A 615 (-4.5A)
ANP  A 615 (-3.3A)
ANP  A 615 (-3.9A)
ANP  A 615 ( 4.0A)
ANP  A 615 (-4.7A)
1.08A 4ckiA-2ozoA:
24.0
4ckiA-2ozoA:
22.51
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2phk PHOSPHORYLASE KINASE

(Oryctolagus
cuniculus)
PF00069
(Pkinase)
6 LEU A  25
GLY A  26
VAL A  33
ALA A  46
GLY A 109
LEU A 156
ATP  A 381 ( 4.3A)
ATP  A 381 (-3.5A)
ATP  A 381 (-4.1A)
ATP  A 381 (-3.5A)
None
ATP  A 381 ( 4.8A)
0.50A 4ckiA-2phkA:
25.9
4ckiA-2phkA:
27.41
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2psq FIBROBLAST GROWTH
FACTOR RECEPTOR 2


(Homo sapiens)
PF07714
(Pkinase_Tyr)
7 LEU A 487
GLY A 488
VAL A 495
ALA A 515
VAL A 564
TYR A 566
ALA A 567
None
0.88A 4ckiA-2psqA:
38.0
4ckiA-2psqA:
44.65
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2psq FIBROBLAST GROWTH
FACTOR RECEPTOR 2


(Homo sapiens)
PF07714
(Pkinase_Tyr)
7 LEU A 487
GLY A 490
VAL A 495
ALA A 515
TYR A 566
ALA A 567
GLY A 570
None
1.25A 4ckiA-2psqA:
38.0
4ckiA-2psqA:
44.65
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2psq FIBROBLAST GROWTH
FACTOR RECEPTOR 2


(Homo sapiens)
PF07714
(Pkinase_Tyr)
6 LEU A 487
GLY A 493
VAL A 495
ALA A 515
VAL A 564
TYR A 566
None
0.92A 4ckiA-2psqA:
38.0
4ckiA-2psqA:
44.65
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2psq FIBROBLAST GROWTH
FACTOR RECEPTOR 2


(Homo sapiens)
PF07714
(Pkinase_Tyr)
8 LEU A 487
VAL A 495
ALA A 515
VAL A 564
TYR A 566
ALA A 567
GLY A 570
LEU A 633
None
0.46A 4ckiA-2psqA:
38.0
4ckiA-2psqA:
44.65
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2qlu ACTIVIN RECEPTOR
TYPE IIB


(Homo sapiens)
PF00069
(Pkinase)
6 GLY A 199
VAL A 204
ALA A 215
GLY A 271
SER A 272
LEU A 328
None
ADE  A 488 ( 4.9A)
ADE  A 488 (-3.2A)
ADE  A 488 ( 4.1A)
None
ADE  A 488 (-4.4A)
0.43A 4ckiA-2qluA:
28.5
4ckiA-2qluA:
23.46
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2qob EPHRIN RECEPTOR

(Homo sapiens)
PF07714
(Pkinase_Tyr)
6 GLY A 628
GLY A 630
VAL A 635
ALA A 651
GLY A 705
LEU A 753
None
None
BME  A   1 (-4.9A)
PTR  A 701 ( 4.7A)
None
None
0.92A 4ckiA-2qobA:
33.6
4ckiA-2qobA:
29.29
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2r2p EPHRIN TYPE-A
RECEPTOR 5


(Homo sapiens)
PF07714
(Pkinase_Tyr)
PF14575
(EphA2_TM)
6 GLY A 682
GLY A 684
VAL A 689
ALA A 705
TYR A 755
GLY A 759
None
0.81A 4ckiA-2r2pA:
35.7
4ckiA-2r2pA:
33.13
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2r2p EPHRIN TYPE-A
RECEPTOR 5


(Homo sapiens)
PF07714
(Pkinase_Tyr)
PF14575
(EphA2_TM)
6 GLY A 682
VAL A 689
ALA A 705
TYR A 755
GLY A 759
LEU A 807
None
0.76A 4ckiA-2r2pA:
35.7
4ckiA-2r2pA:
33.13
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2r2p EPHRIN TYPE-A
RECEPTOR 5


(Homo sapiens)
PF07714
(Pkinase_Tyr)
PF14575
(EphA2_TM)
6 VAL A 689
ALA A 705
TYR A 755
GLY A 759
SER A 760
LEU A 807
None
0.81A 4ckiA-2r2pA:
35.7
4ckiA-2r2pA:
33.13
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2r4b RECEPTOR
TYROSINE-PROTEIN
KINASE ERBB-4


(Homo sapiens)
PF07714
(Pkinase_Tyr)
6 LEU A 724
GLY A 725
VAL A 732
ALA A 749
GLY A 802
LEU A 850
GW7  A   1 ( 4.2A)
None
GW7  A   1 ( 4.8A)
GW7  A   1 (-3.3A)
GW7  A   1 (-3.6A)
GW7  A   1 (-4.2A)
0.47A 4ckiA-2r4bA:
31.4
4ckiA-2r4bA:
32.94
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2wtk SERINE/THREONINE-PRO
TEIN KINASE 11


(Homo sapiens)
PF00069
(Pkinase)
6 LEU C  55
GLY C  56
GLY C  58
VAL C  63
ALA C  76
LEU C 183
ANP  C   2 ( 4.4A)
ANP  C   2 (-3.3A)
ANP  C   2 (-3.0A)
ANP  C   2 (-4.2A)
ANP  C   2 (-3.4A)
None
0.83A 4ckiA-2wtkC:
26.4
4ckiA-2wtkC:
26.07
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2wtk SERINE/THREONINE-PRO
TEIN KINASE 11


(Homo sapiens)
PF00069
(Pkinase)
6 LEU C  55
GLY C  56
VAL C  63
ALA C  76
TYR C 131
LEU C 183
ANP  C   2 ( 4.4A)
ANP  C   2 (-3.3A)
ANP  C   2 (-4.2A)
ANP  C   2 (-3.4A)
None
None
0.53A 4ckiA-2wtkC:
26.4
4ckiA-2wtkC:
26.07
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2x4f MYOSIN LIGHT CHAIN
KINASE FAMILY MEMBER
4


(Homo sapiens)
PF00069
(Pkinase)
6 LEU A 112
GLY A 113
VAL A 120
ALA A 133
TYR A 182
GLY A 186
16X  A1374 (-4.1A)
16X  A1374 (-3.4A)
16X  A1374 (-4.8A)
16X  A1374 ( 3.8A)
16X  A1374 (-4.1A)
16X  A1374 (-4.0A)
0.82A 4ckiA-2x4fA:
24.9
4ckiA-2x4fA:
25.19
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2xik SERINE/THREONINE
PROTEIN KINASE 25


(Homo sapiens)
PF00069
(Pkinase)
8 GLY A  27
GLY A  29
VAL A  34
ALA A  47
TYR A  97
GLY A 101
SER A 102
LEU A 147
J60  A1294 ( 4.1A)
J60  A1294 ( 4.5A)
J60  A1294 ( 4.9A)
J60  A1294 (-3.3A)
J60  A1294 (-4.5A)
J60  A1294 ( 3.8A)
None
J60  A1294 (-4.8A)
0.90A 4ckiA-2xikA:
22.9
4ckiA-2xikA:
25.60
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2xk9 CHECKPOINT KINASE 2

(Homo sapiens)
PF00069
(Pkinase)
7 LEU A 226
GLY A 227
GLY A 229
VAL A 234
ALA A 247
GLY A 307
LEU A 354
XK9  A1511 (-3.8A)
XK9  A1511 ( 4.5A)
None
XK9  A1511 (-4.8A)
XK9  A1511 ( 4.1A)
XK9  A1511 ( 3.7A)
XK9  A1511 (-4.6A)
0.83A 4ckiA-2xk9A:
21.9
4ckiA-2xk9A:
27.12
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2xyu EPHRIN TYPE-A
RECEPTOR 4,


(Mus musculus)
PF07714
(Pkinase_Tyr)
6 GLY A 628
VAL A 635
ALA A 651
TYR A 701
GLY A 705
LEU A 753
None
Q9G  A1898 ( 4.7A)
Q9G  A1898 (-3.2A)
Q9G  A1898 (-4.8A)
Q9G  A1898 ( 3.8A)
Q9G  A1898 (-4.3A)
0.59A 4ckiA-2xyuA:
27.4
4ckiA-2xyuA:
34.78
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2xyu EPHRIN TYPE-A
RECEPTOR 4,


(Mus musculus)
PF07714
(Pkinase_Tyr)
6 GLY A 628
VAL A 635
TYR A 701
GLY A 705
SER A 706
LEU A 753
None
Q9G  A1898 ( 4.7A)
Q9G  A1898 (-4.8A)
Q9G  A1898 ( 3.8A)
Q9G  A1898 ( 4.5A)
Q9G  A1898 (-4.3A)
0.81A 4ckiA-2xyuA:
27.4
4ckiA-2xyuA:
34.78
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2z2w WEE1-LIKE PROTEIN
KINASE


(Homo sapiens)
PF00069
(Pkinase)
6 GLY A 306
VAL A 313
ALA A 326
TYR A 378
GLY A 382
SER A 383
770  A 901 ( 4.6A)
770  A 901 ( 4.7A)
770  A 901 (-3.5A)
770  A 901 (-4.2A)
770  A 901 (-3.4A)
None
0.65A 4ckiA-2z2wA:
25.6
4ckiA-2z2wA:
25.29
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2z7r RIBOSOMAL PROTEIN S6
KINASE ALPHA-1


(Homo sapiens)
PF00069
(Pkinase)
7 LEU A  68
GLY A  69
GLY A  71
VAL A  76
ALA A  92
GLY A 147
LEU A 194
STU  A   1 (-3.8A)
STU  A   1 (-3.3A)
STU  A   1 ( 4.1A)
None
STU  A   1 (-3.3A)
STU  A   1 ( 3.9A)
STU  A   1 (-4.6A)
0.85A 4ckiA-2z7rA:
23.3
4ckiA-2z7rA:
29.49
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2z8c INSULIN RECEPTOR

(Homo sapiens)
PF07714
(Pkinase_Tyr)
6 LEU A1002
GLY A1003
GLY A1005
VAL A1010
ALA A1028
GLY A1082
S91  A   1 ( 4.1A)
S91  A   1 ( 3.9A)
None
S91  A   1 ( 4.9A)
S91  A   1 (-3.2A)
S91  A   1 (-3.3A)
0.18A 4ckiA-2z8cA:
36.0
4ckiA-2z8cA:
40.25
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2zv7 TYROSINE-PROTEIN
KINASE LYN


(Mus musculus)
PF07714
(Pkinase_Tyr)
7 LEU A 253
GLY A 254
VAL A 261
ALA A 273
GLY A 325
SER A 326
LEU A 374
None
0.66A 4ckiA-2zv7A:
15.7
4ckiA-2zv7A:
35.38
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3a62 RIBOSOMAL PROTEIN S6
KINASE BETA-1


(Homo sapiens)
PF00069
(Pkinase)
6 LEU A  97
GLY A  98
GLY A 100
VAL A 105
ALA A 121
TYR A 174
STU  A 400 (-3.8A)
STU  A 400 (-3.6A)
None
STU  A 400 (-4.9A)
STU  A 400 (-3.1A)
STU  A 400 (-4.7A)
0.79A 4ckiA-3a62A:
17.2
4ckiA-3a62A:
26.81
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3b2t FIBROBLAST GROWTH
FACTOR RECEPTOR 2


(Homo sapiens)
PF07714
(Pkinase_Tyr)
10 LEU A 487
GLY A 488
GLY A 490
VAL A 495
ALA A 515
VAL A 564
TYR A 566
ALA A 567
GLY A 570
LEU A 633
M33  A1996 (-4.0A)
M33  A1996 ( 3.8A)
M33  A1996 (-3.0A)
M33  A1996 ( 4.7A)
M33  A1996 (-3.3A)
None
M33  A1996 ( 4.7A)
M33  A1996 (-3.8A)
M33  A1996 ( 4.8A)
M33  A1996 (-4.5A)
0.72A 4ckiA-3b2tA:
29.5
4ckiA-3b2tA:
50.47
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3c1x HEPATOCYTE GROWTH
FACTOR RECEPTOR


(Homo sapiens)
PF07714
(Pkinase_Tyr)
6 GLY A1085
GLY A1087
VAL A1092
ALA A1108
TYR A1159
GLY A1163
None
None
CKK  A1500 ( 4.3A)
CKK  A1500 (-3.2A)
CKK  A1500 (-4.5A)
CKK  A1500 ( 4.5A)
0.90A 4ckiA-3c1xA:
26.5
4ckiA-3c1xA:
31.51
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3c4f BASIC FIBROBLAST
GROWTH FACTOR
RECEPTOR 1


(Homo sapiens)
PF07714
(Pkinase_Tyr)
8 LEU A 484
GLY A 487
ALA A 512
VAL A 561
TYR A 563
ALA A 564
GLY A 567
LEU A 630
C4F  A   1 ( 3.9A)
None
C4F  A   1 (-3.3A)
C4F  A   1 ( 4.8A)
None
C4F  A   1 (-3.5A)
None
C4F  A   1 (-4.6A)
1.21A 4ckiA-3c4fA:
34.3
4ckiA-3c4fA:
51.42
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3c4f BASIC FIBROBLAST
GROWTH FACTOR
RECEPTOR 1


(Homo sapiens)
PF07714
(Pkinase_Tyr)
8 LEU A 484
GLY A 487
VAL A 492
ALA A 512
VAL A 561
TYR A 563
ALA A 564
LEU A 630
C4F  A   1 ( 3.9A)
None
None
C4F  A   1 (-3.3A)
C4F  A   1 ( 4.8A)
None
C4F  A   1 (-3.5A)
C4F  A   1 (-4.6A)
1.25A 4ckiA-3c4fA:
34.3
4ckiA-3c4fA:
51.42
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3c4f BASIC FIBROBLAST
GROWTH FACTOR
RECEPTOR 1


(Homo sapiens)
PF07714
(Pkinase_Tyr)
8 LEU A 484
GLY A 490
VAL A 492
ALA A 512
VAL A 561
TYR A 563
ALA A 564
LEU A 630
C4F  A   1 ( 3.9A)
None
None
C4F  A   1 (-3.3A)
C4F  A   1 ( 4.8A)
None
C4F  A   1 (-3.5A)
C4F  A   1 (-4.6A)
0.78A 4ckiA-3c4fA:
34.3
4ckiA-3c4fA:
51.42
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3d7u TYROSINE-PROTEIN
KINASE CSK


(Homo sapiens)
PF07714
(Pkinase_Tyr)
7 GLY A 202
VAL A 209
ALA A 220
TYR A 268
GLY A 272
SER A 273
LEU A 321
None
0.38A 4ckiA-3d7uA:
28.7
4ckiA-3d7uA:
35.65
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3dtc MITOGEN-ACTIVATED
PROTEIN KINASE
KINASE KINASE 9


(Homo sapiens)
PF07714
(Pkinase_Tyr)
6 GLY A 151
VAL A 158
ALA A 169
ALA A 223
GLY A 226
LEU A 275
VIN  A6331 (-3.5A)
VIN  A6331 (-4.7A)
VIN  A6331 (-3.4A)
VIN  A6331 (-3.8A)
VIN  A6331 (-3.4A)
VIN  A6331 (-4.5A)
0.40A 4ckiA-3dtcA:
26.9
4ckiA-3dtcA:
32.83
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3eb0 PUTATIVE
UNCHARACTERIZED
PROTEIN


(Cryptosporidium
parvum)
PF00069
(Pkinase)
6 LEU A  15
GLY A  16
GLY A  18
VAL A  23
ALA A  36
TYR A 119
DRK  A 384 (-3.8A)
DRK  A 384 ( 4.4A)
None
None
DRK  A 384 (-3.5A)
DRK  A 384 (-4.4A)
0.81A 4ckiA-3eb0A:
23.7
4ckiA-3eb0A:
23.25
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3fme DUAL SPECIFICITY
MITOGEN-ACTIVATED
PROTEIN KINASE
KINASE 6


(Homo sapiens)
PF00069
(Pkinase)
6 LEU A  59
GLY A  60
VAL A  67
ALA A  80
SER A 135
LEU A 186
STU  A   1 (-3.8A)
STU  A   1 (-3.5A)
None
STU  A   1 (-3.4A)
STU  A   1 (-3.2A)
STU  A   1 (-4.4A)
0.55A 4ckiA-3fmeA:
17.8
4ckiA-3fmeA:
25.74
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3fzp PROTEIN TYROSINE
KINASE 2 BETA


(Homo sapiens)
PF07714
(Pkinase_Tyr)
7 LEU A 431
GLY A 432
GLY A 434
VAL A 439
ALA A 455
GLY A 508
LEU A 556
AGS  A 999 ( 4.4A)
AGS  A 999 ( 4.2A)
AGS  A 999 (-3.0A)
AGS  A 999 (-4.6A)
AGS  A 999 (-3.6A)
None
AGS  A 999 (-4.5A)
0.85A 4ckiA-3fzpA:
30.8
4ckiA-3fzpA:
36.21
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3g2f BONE MORPHOGENETIC
PROTEIN RECEPTOR
TYPE-2


(Homo sapiens)
PF00069
(Pkinase)
8 GLY A 210
GLY A 212
VAL A 217
ALA A 228
TYR A 281
GLY A 285
SER A 286
LEU A 340
ADP  A 900 (-3.4A)
ADP  A 900 (-3.0A)
ADP  A 900 (-4.3A)
ADP  A 900 (-3.4A)
None
ADP  A 900 ( 4.2A)
ADP  A 900 (-3.6A)
ADP  A 900 (-4.6A)
0.78A 4ckiA-3g2fA:
29.0
4ckiA-3g2fA:
27.42
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3gbz KINASE, CMGC CDK

(Giardia
intestinalis)
PF00069
(Pkinase)
6 LEU A  21
GLY A  22
GLY A  24
VAL A  29
ALA A  42
TYR A  93
None
0.74A 4ckiA-3gbzA:
12.3
4ckiA-3gbzA:
26.57
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3gbz KINASE, CMGC CDK

(Giardia
intestinalis)
PF00069
(Pkinase)
7 LEU A  21
GLY A  24
VAL A  29
ALA A  42
TYR A  93
ALA A  94
LEU A 143
None
0.95A 4ckiA-3gbzA:
12.3
4ckiA-3gbzA:
26.57
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3h4j SNF1-LIKE PROTEIN
KINASE SSP2


(Schizosaccharomyces
pombe)
no annotation 6 LEU B  40
GLY B  41
GLY B  43
VAL B  48
ALA B  61
TYR B 113
None
0.69A 4ckiA-3h4jB:
15.6
4ckiA-3h4jB:
27.18
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3hdn SERINE/THREONINE-PRO
TEIN KINASE SGK1


(Homo sapiens)
PF00069
(Pkinase)
6 GLY A 105
GLY A 107
VAL A 112
ALA A 125
TYR A 178
LEU A 229
None
GMG  A   1 (-3.3A)
None
GMG  A   1 (-3.4A)
GMG  A   1 ( 4.9A)
GMG  A   1 ( 4.9A)
0.86A 4ckiA-3hdnA:
15.5
4ckiA-3hdnA:
25.06
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3hng VASCULAR ENDOTHELIAL
GROWTH FACTOR
RECEPTOR 1


(Homo sapiens)
PF07714
(Pkinase_Tyr)
8 LEU A 833
GLY A 834
VAL A 841
ALA A 859
VAL A 909
TYR A 911
GLY A 915
LEU A1029
8ST  A2001 ( 4.7A)
None
8ST  A2001 ( 4.6A)
8ST  A2001 ( 3.8A)
8ST  A2001 (-4.1A)
8ST  A2001 (-4.9A)
None
None
0.68A 4ckiA-3hngA:
32.4
4ckiA-3hngA:
42.28
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3iec SERINE/THREONINE-PRO
TEIN KINASE MARK2


(Homo sapiens)
PF00069
(Pkinase)
PF00627
(UBA)
6 GLY A  60
ALA A  80
TYR A 131
ALA A 132
GLY A 135
LEU A 182
None
0.85A 4ckiA-3iecA:
25.8
4ckiA-3iecA:
26.59
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3iec SERINE/THREONINE-PRO
TEIN KINASE MARK2


(Homo sapiens)
PF00069
(Pkinase)
PF00627
(UBA)
6 GLY A  60
VAL A  67
ALA A  80
TYR A 131
ALA A 132
LEU A 182
None
0.76A 4ckiA-3iecA:
25.8
4ckiA-3iecA:
26.59
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3igo CALMODULIN-DOMAIN
PROTEIN KINASE 1


(Cryptosporidium
parvum)
PF00069
(Pkinase)
PF13499
(EF-hand_7)
6 LEU A  82
GLY A  83
GLY A  85
VAL A  90
ALA A 103
LEU A 205
ANP  A 610 ( 4.5A)
ANP  A 610 (-3.5A)
ANP  A 610 (-2.9A)
ANP  A 610 (-3.9A)
ANP  A 610 ( 3.7A)
None
0.78A 4ckiA-3igoA:
20.0
4ckiA-3igoA:
19.85
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3kex RECEPTOR
TYROSINE-PROTEIN
KINASE ERBB-3


(Homo sapiens)
PF07714
(Pkinase_Tyr)
7 LEU A 696
GLY A 697
VAL A 704
TYR A 770
GLY A 774
SER A 775
LEU A 822
ANP  A   1 (-4.4A)
ANP  A   1 (-3.7A)
ANP  A   1 (-3.9A)
ANP  A   1 (-4.3A)
ANP  A   1 ( 4.9A)
None
ANP  A   1 (-4.7A)
0.75A 4ckiA-3kexA:
28.9
4ckiA-3kexA:
28.37
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3lj0 SERINE/THREONINE-PRO
TEIN
KINASE/ENDORIBONUCLE
ASE IRE1


(Saccharomyces
cerevisiae)
PF00069
(Pkinase)
PF06479
(Ribonuc_2-5A)
6 LEU A 680
GLY A 681
GLY A 683
VAL A 689
ALA A 700
LEU A 804
ADP  A2101 ( 4.1A)
ADP  A2101 (-3.6A)
ADP  A2101 (-3.3A)
ADP  A2101 (-4.5A)
ADP  A2101 (-3.5A)
ADP  A2101 (-4.4A)
0.73A 4ckiA-3lj0A:
25.4
4ckiA-3lj0A:
23.77
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3lm5 SERINE/THREONINE-PRO
TEIN KINASE 17B


(Homo sapiens)
PF00069
(Pkinase)
8 LEU A  39
GLY A  40
VAL A  47
ALA A  60
TYR A 112
ALA A 113
GLY A 116
LEU A 165
QUE  A   1 ( 3.8A)
None
QUE  A   1 ( 4.6A)
QUE  A   1 (-3.2A)
QUE  A   1 (-4.9A)
QUE  A   1 (-3.9A)
None
None
0.79A 4ckiA-3lm5A:
25.5
4ckiA-3lm5A:
25.83
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3lw0 INSULIN-LIKE GROWTH
FACTOR 1 RECEPTOR


(Homo sapiens)
PF07714
(Pkinase_Tyr)
6 LEU A1005
GLY A1006
GLY A1008
VAL A1013
ALA A1031
GLY A1085
None
0.62A 4ckiA-3lw0A:
30.3
4ckiA-3lw0A:
39.05
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ma6 CALMODULIN-DOMAIN
PROTEIN KINASE 1


(Toxoplasma
gondii)
PF00069
(Pkinase)
6 LEU A  40
GLY A  41
GLY A  43
VAL A  48
ALA A  61
LEU A 164
DXR  A 299 ( 4.3A)
DXR  A 299 ( 4.2A)
DXR  A 299 ( 4.1A)
DXR  A 299 (-4.3A)
DXR  A 299 ( 3.9A)
None
0.83A 4ckiA-3ma6A:
22.1
4ckiA-3ma6A:
27.91
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3mdy BONE MORPHOGENETIC
PROTEIN RECEPTOR
TYPE-1B


(Homo sapiens)
PF07714
(Pkinase_Tyr)
PF08515
(TGF_beta_GS)
8 GLY A 211
GLY A 213
VAL A 218
ALA A 229
TYR A 281
GLY A 285
SER A 286
LEU A 339
LDN  A   1 ( 4.7A)
LDN  A   1 ( 4.4A)
LDN  A   1 ( 4.8A)
LDN  A   1 (-3.6A)
LDN  A   1 ( 4.8A)
LDN  A   1 (-3.3A)
None
LDN  A   1 (-4.5A)
0.72A 4ckiA-3mdyA:
29.0
4ckiA-3mdyA:
26.37
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3mtl CELL DIVISION
PROTEIN KINASE 16


(Homo sapiens)
PF00069
(Pkinase)
6 LEU A 171
GLY A 172
VAL A 179
ALA A 192
TYR A 242
LEU A 293
FEF  A 668 ( 3.8A)
FEF  A 668 ( 4.2A)
FEF  A 668 (-4.9A)
FEF  A 668 (-3.3A)
FEF  A 668 (-4.7A)
FEF  A 668 (-4.2A)
0.54A 4ckiA-3mtlA:
22.4
4ckiA-3mtlA:
24.53
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3mvj CAMP-DEPENDENT
PROTEIN KINASE
CATALYTIC SUBUNIT
ALPHA


(Homo sapiens)
PF00069
(Pkinase)
7 LEU A  49
GLY A  50
VAL A  57
ALA A  70
TYR A 122
GLY A 126
LEU A 173
XFE  A 351 (-4.2A)
XFE  A 351 ( 4.0A)
XFE  A 351 ( 4.5A)
XFE  A 351 (-3.2A)
None
None
XFE  A 351 (-4.6A)
0.69A 4ckiA-3mvjA:
25.7
4ckiA-3mvjA:
24.82
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3my0 SERINE/THREONINE-PRO
TEIN KINASE RECEPTOR
R3


(Homo sapiens)
PF07714
(Pkinase_Tyr)
7 GLY A 209
VAL A 216
ALA A 227
TYR A 279
GLY A 283
SER A 284
LEU A 337
None
LDN  A 600 (-4.5A)
LDN  A 600 (-3.2A)
LDN  A 600 (-4.7A)
LDN  A 600 (-3.3A)
None
LDN  A 600 (-4.6A)
0.81A 4ckiA-3my0A:
27.4
4ckiA-3my0A:
24.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3nie MAP2 KINASE

(Plasmodium
falciparum)
PF00069
(Pkinase)
6 GLY A  37
GLY A  39
VAL A  44
ALA A  57
ALA A 114
LEU A 163
ANP  A 430 (-3.5A)
ANP  A 430 (-3.0A)
ANP  A 430 (-4.2A)
ANP  A 430 (-3.5A)
ANP  A 430 (-3.9A)
ANP  A 430 (-4.4A)
0.76A 4ckiA-3nieA:
23.9
4ckiA-3nieA:
22.48
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3nuu PKB-LIKE

(Homo sapiens)
PF00069
(Pkinase)
8 LEU A  88
GLY A  89
GLY A  91
VAL A  96
ALA A 109
TYR A 161
ALA A 162
LEU A 212
JOZ  A 361 (-4.1A)
JOZ  A 361 ( 4.3A)
SO4  A   5 ( 4.4A)
JOZ  A 361 ( 4.7A)
JOZ  A 361 (-3.4A)
None
JOZ  A 361 (-3.8A)
None
0.81A 4ckiA-3nuuA:
26.8
4ckiA-3nuuA:
27.06
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3nuu PKB-LIKE

(Homo sapiens)
PF00069
(Pkinase)
8 LEU A  88
GLY A  89
VAL A  96
ALA A 109
TYR A 161
ALA A 162
GLY A 165
LEU A 212
JOZ  A 361 (-4.1A)
JOZ  A 361 ( 4.3A)
JOZ  A 361 ( 4.7A)
JOZ  A 361 (-3.4A)
None
JOZ  A 361 (-3.8A)
None
None
0.74A 4ckiA-3nuuA:
26.8
4ckiA-3nuuA:
27.06
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3nyo G PROTEIN-COUPLED
RECEPTOR KINASE 6


(Homo sapiens)
PF00069
(Pkinase)
PF00615
(RGS)
7 LEU A 192
GLY A 193
GLY A 195
VAL A 200
ALA A 213
GLY A 269
LEU A 318
AMP  A 577 ( 4.3A)
AMP  A 577 ( 3.7A)
AMP  A 577 (-3.4A)
AMP  A 577 (-4.3A)
AMP  A 577 (-3.4A)
None
AMP  A 577 (-4.8A)
0.75A 4ckiA-3nyoA:
26.0
4ckiA-3nyoA:
21.50
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3pp0 RECEPTOR
TYROSINE-PROTEIN
KINASE ERBB-2


(Homo sapiens)
PF07714
(Pkinase_Tyr)
7 LEU A 726
GLY A 727
GLY A 729
VAL A 734
ALA A 751
GLY A 804
LEU A 852
03Q  A   1 (-3.8A)
None
03Q  A   1 (-3.3A)
03Q  A   1 (-4.5A)
03Q  A   1 (-3.1A)
03Q  A   1 ( 3.9A)
03Q  A   1 (-4.4A)
0.51A 4ckiA-3pp0A:
34.5
4ckiA-3pp0A:
31.84
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3ppz SERINE/THREONINE-PRO
TEIN KINASE CTR1


(Arabidopsis
thaliana)
PF07714
(Pkinase_Tyr)
7 GLY A 558
VAL A 565
ALA A 576
TYR A 627
GLY A 631
SER A 632
LEU A 683
STU  A   1 (-3.2A)
STU  A   1 (-4.9A)
STU  A   1 (-3.3A)
STU  A   1 (-4.4A)
STU  A   1 (-3.2A)
STU  A   1 ( 4.3A)
STU  A   1 (-4.3A)
0.61A 4ckiA-3ppzA:
32.1
4ckiA-3ppzA:
32.35
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3q4t ACTIVIN RECEPTOR
TYPE-2A


(Homo sapiens)
PF00069
(Pkinase)
6 GLY A 201
VAL A 206
ALA A 217
GLY A 273
SER A 274
LEU A 329
None
TAK  A   2 ( 4.9A)
TAK  A   2 (-3.5A)
TAK  A   2 (-3.6A)
None
TAK  A   2 (-4.6A)
0.48A 4ckiA-3q4tA:
28.0
4ckiA-3q4tA:
23.77
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3qa8 MGC80376 PROTEIN

(Xenopus laevis)
PF00069
(Pkinase)
6 LEU A  21
GLY A  22
GLY A  24
VAL A  29
ALA A  42
TYR A  98
None
0.87A 4ckiA-3qa8A:
19.5
4ckiA-3qa8A:
18.77
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3she MAP KINASE-ACTIVATED
PROTEIN KINASE 3


(Homo sapiens)
PF00069
(Pkinase)
6 LEU A  50
GLY A  51
GLY A  53
VAL A  58
ALA A  71
LEU A 173
I85  A 350 (-3.7A)
I85  A 350 (-3.5A)
I85  A 350 (-3.1A)
I85  A 350 (-4.9A)
I85  A 350 (-3.3A)
None
0.88A 4ckiA-3sheA:
20.9
4ckiA-3sheA:
25.62
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3sxf CALMODULIN-DOMAIN
PROTEIN KINASE 1


(Toxoplasma
gondii)
PF00069
(Pkinase)
PF13499
(EF-hand_7)
6 LEU A  57
GLY A  58
GLY A  60
VAL A  65
ALA A  78
LEU A 181
BK5  A 701 ( 4.2A)
BK5  A 701 ( 3.8A)
BK5  A 701 ( 4.6A)
BK5  A 701 (-4.2A)
BK5  A 701 (-3.4A)
None
0.65A 4ckiA-3sxfA:
22.0
4ckiA-3sxfA:
20.69
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3sxs CYTOPLASMIC
TYROSINE-PROTEIN
KINASE BMX


(Homo sapiens)
PF07714
(Pkinase_Tyr)
8 LEU A 423
GLY A 424
GLY A 426
VAL A 431
ALA A 443
TYR A 491
GLY A 495
LEU A 543
PP2  A   1 (-4.1A)
PP2  A   1 ( 4.1A)
PP2  A   1 ( 4.8A)
PP2  A   1 (-4.5A)
PP2  A   1 (-3.2A)
PP2  A   1 ( 4.9A)
PP2  A   1 ( 4.2A)
PP2  A   1 (-4.6A)
0.53A 4ckiA-3sxsA:
33.6
4ckiA-3sxsA:
35.22
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3tt0 BASIC FIBROBLAST
GROWTH FACTOR
RECEPTOR 1


(Homo sapiens)
PF07714
(Pkinase_Tyr)
7 LEU A 484
GLY A 485
GLY A 487
VAL A 492
ALA A 512
VAL A 561
TYR A 563
07J  A   1 ( 4.3A)
07J  A   1 ( 4.9A)
None
07J  A   1 (-4.0A)
07J  A   1 (-3.5A)
07J  A   1 (-4.7A)
07J  A   1 (-4.7A)
0.78A 4ckiA-3tt0A:
34.0
4ckiA-3tt0A:
48.55
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3tt0 BASIC FIBROBLAST
GROWTH FACTOR
RECEPTOR 1


(Homo sapiens)
PF07714
(Pkinase_Tyr)
9 LEU A 484
GLY A 485
VAL A 492
ALA A 512
VAL A 561
TYR A 563
ALA A 564
GLY A 567
LEU A 630
07J  A   1 ( 4.3A)
07J  A   1 ( 4.9A)
07J  A   1 (-4.0A)
07J  A   1 (-3.5A)
07J  A   1 (-4.7A)
07J  A   1 (-4.7A)
07J  A   1 (-3.8A)
07J  A   1 (-3.7A)
07J  A   1 ( 4.4A)
0.67A 4ckiA-3tt0A:
34.0
4ckiA-3tt0A:
48.55
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ulz BRASSINOSTEROID
INSENSITIVE
1-ASSOCIATED
RECEPTOR KINASE 1


(Arabidopsis
thaliana)
PF00069
(Pkinase)
8 LEU A 295
GLY A 296
GLY A 298
VAL A 303
ALA A 315
TYR A 365
GLY A 369
LEU A 423
None
1.14A 4ckiA-3ulzA:
26.4
4ckiA-3ulzA:
27.20
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ulz BRASSINOSTEROID
INSENSITIVE
1-ASSOCIATED
RECEPTOR KINASE 1


(Arabidopsis
thaliana)
PF00069
(Pkinase)
8 LEU A 295
GLY A 296
VAL A 303
ALA A 315
TYR A 365
GLY A 369
SER A 370
LEU A 423
None
0.74A 4ckiA-3ulzA:
26.4
4ckiA-3ulzA:
27.20
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3v5q NT-3 GROWTH FACTOR
RECEPTOR


(Homo sapiens)
PF07714
(Pkinase_Tyr)
6 LEU A 544
VAL A 552
ALA A 570
TYR A 619
GLY A 623
LEU A 686
0F4  A 902 ( 4.2A)
None
0F4  A 902 (-3.2A)
0F4  A 902 (-4.2A)
0F4  A 902 (-3.4A)
0F4  A 902 (-4.5A)
0.43A 4ckiA-3v5qA:
30.0
4ckiA-3v5qA:
37.03
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3vid VASCULAR ENDOTHELIAL
GROWTH FACTOR
RECEPTOR 2


(Homo sapiens)
PF07714
(Pkinase_Tyr)
7 LEU A 840
GLY A 841
VAL A 848
ALA A 866
VAL A 916
GLY A 922
LEU A1035
4TT  A2001 ( 4.0A)
4TT  A2001 ( 4.8A)
4TT  A2001 ( 4.5A)
4TT  A2001 (-3.5A)
None
4TT  A2001 (-3.7A)
4TT  A2001 (-4.8A)
0.61A 4ckiA-3vidA:
32.0
4ckiA-3vidA:
42.82
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3vn9 DUAL SPECIFICITY
MITOGEN-ACTIVATED
PROTEIN KINASE
KINASE 6


(Homo sapiens)
PF00069
(Pkinase)
6 LEU A  59
GLY A  60
VAL A  67
ALA A  80
SER A 135
LEU A 186
None
ANK  A 401 (-3.4A)
ANK  A 401 (-4.3A)
ANK  A 401 (-3.0A)
ANK  A 401 (-3.7A)
ANK  A 401 ( 4.9A)
0.87A 4ckiA-3vn9A:
22.1
4ckiA-3vn9A:
24.18
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3w18 AURORA KINASE A

(Homo sapiens)
PF00069
(Pkinase)
8 LEU A 139
GLY A 140
VAL A 147
ALA A 160
TYR A 212
ALA A 213
GLY A 216
LEU A 263
N13  A 501 (-3.7A)
None
N13  A 501 ( 4.7A)
N13  A 501 ( 4.1A)
N13  A 501 (-4.4A)
N13  A 501 (-3.7A)
N13  A 501 (-3.5A)
N13  A 501 (-4.5A)
0.70A 4ckiA-3w18A:
22.6
4ckiA-3w18A:
26.20
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3wig DUAL SPECIFICITY
MITOGEN-ACTIVATED
PROTEIN KINASE
KINASE 1


(Homo sapiens)
PF00069
(Pkinase)
7 LEU A  75
GLY A  76
GLY A  78
VAL A  83
ALA A  96
GLY A 150
SER A 151
ANP  A 401 (-3.8A)
ANP  A 401 ( 3.7A)
ANP  A 401 (-3.3A)
ANP  A 401 ( 4.3A)
ANP  A 401 (-3.2A)
ANP  A 401 ( 4.3A)
ANP  A 401 (-3.3A)
0.84A 4ckiA-3wigA:
22.5
4ckiA-3wigA:
26.27
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3wig DUAL SPECIFICITY
MITOGEN-ACTIVATED
PROTEIN KINASE
KINASE 1


(Homo sapiens)
PF00069
(Pkinase)
7 LEU A  75
GLY A  76
VAL A  83
ALA A  96
GLY A 150
SER A 151
LEU A 198
ANP  A 401 (-3.8A)
ANP  A 401 ( 3.7A)
ANP  A 401 ( 4.3A)
ANP  A 401 (-3.2A)
ANP  A 401 ( 4.3A)
ANP  A 401 (-3.3A)
ANP  A 401 (-4.8A)
0.56A 4ckiA-3wigA:
22.5
4ckiA-3wigA:
26.27