SIMILAR PATTERNS OF AMINO ACIDS FOR 4CI3_B_Y70B1429_1

List of similar pattern of amino acids derived from ASSAM search

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click link on the last column to view superposed patterns of amino acids in NGL viewer)
(Note that only 3-12 residue patterns can be used for ASSAM searches)
Filter list by:
Hit Macromolecule/
Organism		 Pfam Res. Interface HETATM RMSD Dali Z-score Seq. Identity (%) View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2a3k PROTEIN TYROSINE
PHOSPHATASE,
NON-RECEPTOR TYPE 7,
ISOFORM 1

(Homo sapiens) 		PF00102
(Y_phosphatase) 		5 PRO A 171
HIS A 290
SER A 177
TRP A 180
PHE A 218
 None
 1.30A 4ci3B-2a3kA:
0.0		 4ci3B-2a3kA:
22.46
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4ci2 PROTEIN CEREBLON

(Gallus gallus) 		PF02190
(LON_substr_bdg)
PF03226
(Yippee-Mis18) 		10 ASN B 353
PRO B 354
HIS B 355
HIS B 359
HIS B 380
SER B 381
TRP B 382
TRP B 388
TRP B 402
PHE B 404
 LVY  B1429 (-4.1A)
LVY  B1429 (-4.7A)
LVY  B1429 (-4.5A)
LVY  B1429 ( 4.8A)
LVY  B1429 (-4.0A)
LVY  B1429 (-3.8A)
LVY  B1429 (-3.1A)
LVY  B1429 (-3.5A)
LVY  B1429 (-3.7A)
LVY  B1429 (-4.5A)
 0.12A 4ci3B-4ci2B:
58.3		 4ci3B-4ci2B:
100.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4tzc PROTEIN CEREBLON

(Mus musculus) 		no annotation 5 SER C 381
TRP C 382
TRP C 388
TRP C 402
PHE C 404
 EF2  C 502 (-4.1A)
EF2  C 502 ( 3.2A)
EF2  C 502 (-3.5A)
EF2  C 502 (-3.8A)
EF2  C 502 (-4.5A)
 0.23A 4ci3B-4tzcC:
0.0		 4ci3B-4tzcC:
21.88
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4v30 CEREBLON ISOFORM 4

(Magnetospirillum
gryphiswaldense) 		no annotation 6 ASN A  50
PRO A  51
SER A  78
TRP A  79
TRP A  85
TRP A  99
 LVY  A 151 (-3.8A)
LVY  A 151 (-4.4A)
LVY  A 151 (-4.0A)
LVY  A 151 (-3.2A)
LVY  A 151 (-3.4A)
LVY  A 151 (-3.7A)
 0.40A 4ci3B-4v30A:
0.0		 4ci3B-4v30A:
16.01
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5hxb PROTEIN CEREBLON

(Homo sapiens) 		no annotation 10 ASN Z 351
PRO Z 352
HIS Z 353
HIS Z 357
HIS Z 378
SER Z 379
TRP Z 380
TRP Z 386
TRP Z 400
PHE Z 402
 85C  Z 502 (-3.6A)
85C  Z 502 (-4.4A)
85C  Z 502 (-3.9A)
None
85C  Z 502 (-3.8A)
85C  Z 502 (-3.2A)
85C  Z 502 (-3.2A)
85C  Z 502 (-3.4A)
85C  Z 502 (-3.7A)
None
 0.49A 4ci3B-5hxbZ:
50.9		 4ci3B-5hxbZ:
78.52
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5hxb PROTEIN CEREBLON

(Homo sapiens) 		no annotation 5 ASN Z 351
PRO Z 352
HIS Z 378
SER Z 379
PHE Z 381
 85C  Z 502 (-3.6A)
85C  Z 502 (-4.4A)
85C  Z 502 (-3.8A)
85C  Z 502 (-3.2A)
None
 1.32A 4ci3B-5hxbZ:
50.9		 4ci3B-5hxbZ:
78.52