SIMILAR PATTERNS OF AMINO ACIDS FOR 4C9P_B_CAMB423_0

List of similar pattern of amino acids derived from ASSAM search

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click link on the last column to view superposed patterns of amino acids in NGL viewer)
(Note that only 3-12 residue patterns can be used for ASSAM searches)
Filter list by:
Hit Macromolecule/
Organism		 Pfam Res. Interface HETATM RMSD Dali Z-score Seq. Identity (%) View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1bs0 PROTEIN
(8-AMINO-7-OXONANOAT
E SYNTHASE)

(Escherichia
coli) 		PF00155
(Aminotran_1_2) 		5 THR A 209
GLY A 242
VAL A 231
ASP A 204
VAL A 232
 None
 1.35A 4c9pB-1bs0A:
undetectable		 4c9pB-1bs0A:
22.47
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1col COLICIN A

(Escherichia
coli) 		PF01024
(Colicin) 		5 TYR A 125
LEU A 178
LEU A 179
GLY A 176
VAL A 167
 None
 1.23A 4c9pB-1colA:
0.0		 4c9pB-1colA:
19.12
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1d2k CHITINASE 1

(Coccidioides
immitis) 		PF00704
(Glyco_hydro_18) 		5 TRP A 377
THR A  65
LEU A 404
LEU A 398
VAL A 287
 None
 1.29A 4c9pB-1d2kA:
0.0		 4c9pB-1d2kA:
20.61
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1fsu N-ACETYLGALACTOSAMIN
E-4-SULFATASE

(Homo sapiens) 		PF00884
(Sulfatase) 		5 THR A 368
THR A 107
LEU A 371
GLY A 101
VAL A 122
 None
 1.20A 4c9pB-1fsuA:
0.0		 4c9pB-1fsuA:
22.96
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1gso PROTEIN (GLYCINAMIDE
RIBONUCLEOTIDE
SYNTHETASE)

(Escherichia
coli) 		PF01071
(GARS_A)
PF02843
(GARS_C)
PF02844
(GARS_N) 		5 THR A 296
THR A  37
GLY A   9
VAL A   5
VAL A  30
 None
 1.35A 4c9pB-1gsoA:
0.0		 4c9pB-1gsoA:
22.65
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1hxi PEROXISOME TARGETING
SIGNAL 1 RECEPTOR
PEX5

(Trypanosoma
brucei) 		no annotation 5 THR A 392
LEU A 360
LEU A 357
GLY A 356
VAL A 375
 None
 1.25A 4c9pB-1hxiA:
undetectable		 4c9pB-1hxiA:
15.20
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1hyl HYPODERMA LINEATUM
COLLAGENASE

(Hypoderma
lineatum) 		PF00089
(Trypsin) 		5 TRP A  41
GLY A  76
VAL A  65
ASP A  34
VAL A  66
 None
 1.20A 4c9pB-1hylA:
0.0		 4c9pB-1hylA:
20.90
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1n0w DNA REPAIR PROTEIN
RAD51 HOMOLOG 1

(Homo sapiens) 		PF08423
(Rad51) 		5 THR A 298
LEU A 109
LEU A 113
GLY A 116
VAL A 264
 None
None
MG  A 401 (-4.2A)
MG  A 401 (-3.8A)
None
 1.21A 4c9pB-1n0wA:
undetectable		 4c9pB-1n0wA:
21.41
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1s4d UROPORPHYRIN-III
C-METHYLTRANSFERASE

(Pseudomonas
denitrificans
(nomen
rejiciendum)) 		PF00590
(TP_methylase) 		5 TYR A 183
THR A 130
LEU A 136
VAL A 152
VAL A 179
 SAH  A1501 (-4.8A)
SAH  A1501 ( 3.6A)
None
None
None
 1.24A 4c9pB-1s4dA:
undetectable		 4c9pB-1s4dA:
22.07
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1t1s 1-DEOXY-D-XYLULOSE
5-PHOSPHATE
REDUCTOISOMERASE

(Escherichia
coli) 		PF02670
(DXP_reductoisom)
PF08436
(DXP_redisom_C)
PF13288
(DXPR_C) 		5 THR A 332
LEU A 127
GLY A 131
VAL A 374
VAL A 377
 None
 1.31A 4c9pB-1t1sA:
0.0		 4c9pB-1t1sA:
21.97
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1umg 385AA LONG CONSERVED
HYPOTHETICAL PROTEIN

(Sulfurisphaera
tokodaii) 		PF01950
(FBPase_3) 		5 THR A  49
LEU A 292
LEU A 293
GLY A 294
VAL A   8
 None
 1.18A 4c9pB-1umgA:
undetectable		 4c9pB-1umgA:
23.50
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1v8b ADENOSYLHOMOCYSTEINA
SE

(Plasmodium
falciparum) 		PF00670
(AdoHcyase_NAD)
PF05221
(AdoHcyase) 		5 THR A 251
LEU A 384
LEU A 390
GLY A 341
VAL A 260
 None
 1.22A 4c9pB-1v8bA:
undetectable		 4c9pB-1v8bA:
21.11
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1xb7 STEROID HORMONE
RECEPTOR ERR1

(Homo sapiens) 		PF00104
(Hormone_recep) 		5 LEU A 398
LEU A 401
GLY A 402
VAL A 369
VAL A 366
 None
 1.18A 4c9pB-1xb7A:
undetectable		 4c9pB-1xb7A:
21.89
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1y1p ALDEHYDE REDUCTASE
II

(Sporidiobolus
salmonicolor) 		PF01370
(Epimerase) 		5 THR A 312
LEU A 316
LEU A 319
GLY A 326
VAL A 248
 None
 1.28A 4c9pB-1y1pA:
undetectable		 4c9pB-1y1pA:
21.08
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1z7d ORNITHINE
AMINOTRANSFERASE

(Plasmodium
yoelii) 		PF00202
(Aminotran_3) 		5 THR A 385
THR A 381
LEU A 348
GLY A 203
VAL A 377
 None
 1.22A 4c9pB-1z7dA:
undetectable		 4c9pB-1z7dA:
23.35
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2bpq ANTHRANILATE
PHOSPHORIBOSYLTRANSF
ERASE

(Mycobacterium
tuberculosis) 		PF00591
(Glycos_transf_3)
PF02885
(Glycos_trans_3N) 		5 LEU A 242
LEU A 218
GLY A 217
VAL A 131
VAL A 126
 None
 1.35A 4c9pB-2bpqA:
undetectable		 4c9pB-2bpqA:
24.07
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2e7u GLUTAMATE-1-SEMIALDE
HYDE 2,1-AMINOMUTASE

(Thermus
thermophilus) 		PF00202
(Aminotran_3) 		5 TRP A 394
LEU A 417
LEU A 420
VAL A 350
VAL A 359
 None
 1.33A 4c9pB-2e7uA:
undetectable		 4c9pB-2e7uA:
24.49
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2ipc PREPROTEIN
TRANSLOCASE SECA
SUBUNIT

(Thermus
thermophilus) 		PF01043
(SecA_PP_bind)
PF07516
(SecA_SW)
PF07517
(SecA_DEAD) 		5 LEU A 111
GLY A  88
VAL A  24
ASP A  82
VAL A  27
 None
 1.36A 4c9pB-2ipcA:
undetectable		 4c9pB-2ipcA:
18.56
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2m56 CAMPHOR
5-MONOOXYGENASE

(Pseudomonas
putida) 		PF00067
(p450) 		5 TYR A  96
THR A 101
LEU A 244
GLY A 248
VAL A 295
 CAM  A 502 (-4.5A)
HEM  A 501 (-2.9A)
HEM  A 501 (-4.5A)
HEM  A 501 (-3.9A)
HEM  A 501 (-4.6A)
 1.17A 4c9pB-2m56A:
57.6		 4c9pB-2m56A:
44.21
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2m56 CAMPHOR
5-MONOOXYGENASE

(Pseudomonas
putida) 		PF00067
(p450) 		8 TYR A  96
THR A 101
THR A 185
LEU A 244
GLY A 248
VAL A 295
ASP A 297
VAL A 396
 CAM  A 502 (-4.5A)
HEM  A 501 (-2.9A)
None
HEM  A 501 (-4.5A)
HEM  A 501 (-3.9A)
HEM  A 501 (-4.6A)
HEM  A 501 (-2.8A)
None
 0.69A 4c9pB-2m56A:
57.6		 4c9pB-2m56A:
44.21
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2oga TRANSAMINASE

(Streptomyces
venezuelae) 		PF01041
(DegT_DnrJ_EryC1) 		5 THR A 206
LEU A 218
GLY A  77
VAL A 162
VAL A 184
 None
 1.17A 4c9pB-2ogaA:
undetectable		 4c9pB-2ogaA:
24.68
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2p3j VP4

(Rotavirus A) 		PF00426
(VP4_haemagglut) 		5 THR A 191
THR A 176
LEU A 103
GLY A  95
VAL A 167
 None
 1.17A 4c9pB-2p3jA:
undetectable		 4c9pB-2p3jA:
14.36
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2pbi REGULATOR OF
G-PROTEIN SIGNALING
9
GUANINE
NUCLEOTIDE-BINDING
PROTEIN SUBUNIT BETA
5

(Mus musculus;
Mus musculus) 		PF00610
(DEP)
PF00615
(RGS)
PF00631
(G-gamma)
PF00400
(WD40) 		5 TYR B 155
THR A 209
LEU B 199
GLY B 216
ASP B 174
 None
 1.35A 4c9pB-2pbiB:
undetectable		 4c9pB-2pbiB:
21.19
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2pfy PUTATIVE EXPORTED
PROTEIN

(Bordetella
pertussis) 		PF03480
(DctP) 		5 THR A  99
LEU A 295
LEU A 296
ASP A  80
VAL A  82
 None
 1.27A 4c9pB-2pfyA:
undetectable		 4c9pB-2pfyA:
21.38
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2wu0 PHYTASE

(Klebsiella
pneumoniae) 		PF00328
(His_Phos_2) 		5 THR A 104
GLY A  58
VAL A  65
ASP A 110
VAL A  64
 None
 1.05A 4c9pB-2wu0A:
undetectable		 4c9pB-2wu0A:
24.07
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2yg8 DNA-3-METHYLADENINE
GLYCOSIDASE II,
PUTATIVE

(Deinococcus
radiodurans) 		PF00730
(HhH-GPD) 		5 THR A 197
GLY A 183
VAL A  41
ASP A  39
VAL A  45
 None
None
GOL  A1228 (-4.2A)
None
None
 1.26A 4c9pB-2yg8A:
undetectable		 4c9pB-2yg8A:
22.73
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2zwv PROBABLE RIBOSOMAL
RNA SMALL SUBUNIT
METHYLTRANSFERASE

(Thermus
thermophilus) 		PF05175
(MTS) 		5 LEU A 220
LEU A 223
VAL A 258
ASP A 239
VAL A 237
 None
None
None
SAH  A 376 ( 4.2A)
None
 1.21A 4c9pB-2zwvA:
undetectable		 4c9pB-2zwvA:
25.16
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3asa LL-DIAMINOPIMELATE
AMINOTRANSFERASE

(Chlamydia
trachomatis) 		PF00155
(Aminotran_1_2) 		5 TRP A 247
THR A 207
LEU A 292
LEU A 289
GLY A 288
 None
 0.92A 4c9pB-3asaA:
undetectable		 4c9pB-3asaA:
23.69
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3b3d PUTATIVE MORPHINE
DEHYDROGENASE

(Bacillus
subtilis) 		PF00248
(Aldo_ket_red) 		5 THR A  50
LEU A 107
LEU A 105
GLY A  61
VAL A  24
 None
 1.13A 4c9pB-3b3dA:
undetectable		 4c9pB-3b3dA:
23.57
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3bn3 INTERCELLULAR
ADHESION MOLECULE 5

(Homo sapiens) 		PF03921
(ICAM_N) 		5 THR B  45
THR B  38
LEU B  52
LEU B  36
GLY B  35
 None
 1.32A 4c9pB-3bn3B:
undetectable		 4c9pB-3bn3B:
19.50
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ce6 ADENOSYLHOMOCYSTEINA
SE

(Mycobacterium
tuberculosis) 		PF00670
(AdoHcyase_NAD)
PF05221
(AdoHcyase) 		5 THR A 269
LEU A 402
LEU A 408
GLY A 359
VAL A 278
 None
 1.21A 4c9pB-3ce6A:
undetectable		 4c9pB-3ce6A:
21.79
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3f9t L-TYROSINE
DECARBOXYLASE MFNA

(Methanocaldococcus
jannaschii) 		PF00282
(Pyridoxal_deC) 		5 LEU A  99
LEU A 102
GLY A 138
ASP A 206
VAL A 127
 None
None
None
PLP  A 500 (-2.6A)
None
 1.29A 4c9pB-3f9tA:
undetectable		 4c9pB-3f9tA:
20.96
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3fha ENDO-BETA-N-ACETYLGL
UCOSAMINIDASE

(Glutamicibacter
protophormiae) 		PF03644
(Glyco_hydro_85) 		5 TRP A 282
LEU A  55
LEU A 296
GLY A 297
VAL A 271
 None
 1.28A 4c9pB-3fhaA:
undetectable		 4c9pB-3fhaA:
21.71
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3g1u ADENOSYLHOMOCYSTEINA
SE

(Leishmania
major) 		PF00670
(AdoHcyase_NAD)
PF05221
(AdoHcyase) 		5 THR A 274
LEU A 191
GLY A 226
VAL A 240
VAL A 217
 None
 1.25A 4c9pB-3g1uA:
undetectable		 4c9pB-3g1uA:
22.58
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3jq3 LOMBRICINE KINASE

(Urechis caupo) 		PF00217
(ATP-gua_Ptrans)
PF02807
(ATP-gua_PtransN) 		5 THR A 120
LEU A 244
LEU A  98
GLY A 241
VAL A 337
 None
 1.28A 4c9pB-3jq3A:
undetectable		 4c9pB-3jq3A:
22.63
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3mwt NUCLEOPROTEIN

(Lassa
mammarenavirus) 		PF00843
(Arena_nucleocap)
PF17290
(Arena_ncap_C) 		5 THR A 324
LEU A 182
GLY A 243
VAL A  50
VAL A  47
 None
 1.26A 4c9pB-3mwtA:
undetectable		 4c9pB-3mwtA:
23.01
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ndn O-SUCCINYLHOMOSERINE
SULFHYDRYLASE

(Mycobacterium
tuberculosis) 		PF01053
(Cys_Met_Meta_PP) 		5 THR A 181
THR A 166
LEU A 193
GLY A 205
ASP A 176
 None
 1.05A 4c9pB-3ndnA:
undetectable		 4c9pB-3ndnA:
20.98
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3one ADENOSYLHOMOCYSTEINA
SE

(Lupinus luteus) 		PF00670
(AdoHcyase_NAD)
PF05221
(AdoHcyase) 		5 THR A 324
LEU A 241
GLY A 276
VAL A 290
VAL A 267
 None
 1.27A 4c9pB-3oneA:
undetectable		 4c9pB-3oneA:
22.18
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3piq HUMAN MONOCLONAL
ANTIBODY 2909 FAB
HEAVY CHAIN

(Homo sapiens) 		no annotation 5 THR H 165
LEU H 124
GLY H 139
VAL H 198
VAL H 152
 None
 1.34A 4c9pB-3piqH:
undetectable		 4c9pB-3piqH:
18.80
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3rfy PEPTIDYL-PROLYL
CIS-TRANS ISOMERASE
CYP38, CHLOROPLASTIC

(Arabidopsis
thaliana) 		PF00160
(Pro_isomerase) 		5 THR A 401
LEU A 262
VAL A 422
ASP A 242
VAL A 421
 None
 1.11A 4c9pB-3rfyA:
undetectable		 4c9pB-3rfyA:
23.76
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3rnq PROGRAMMED CELL
DEATH 1 LIGAND 2

(Mus musculus) 		PF08205
(C2-set_2) 		5 TYR B 123
LEU B 173
GLY B 172
VAL B 119
VAL B  34
 None
 1.07A 4c9pB-3rnqB:
undetectable		 4c9pB-3rnqB:
18.03
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3sh5 LG3 PEPTIDE

(Homo sapiens) 		PF00054
(Laminin_G_1) 		5 THR A  40
LEU A  73
LEU A  68
GLY A  67
VAL A 160
 None
 1.10A 4c9pB-3sh5A:
undetectable		 4c9pB-3sh5A:
22.44
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3t4c 2-DEHYDRO-3-DEOXYPHO
SPHOOCTONATE
ALDOLASE 1

(Burkholderia
ambifaria) 		PF00793
(DAHP_synth_1) 		5 TYR A  49
THR A  29
THR A  89
LEU A  76
GLY A  72
 None
 0.98A 4c9pB-3t4cA:
undetectable		 4c9pB-3t4cA:
22.75
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3t5q NUCLEOPROTEIN

(Mopeia Lassa
virus
reassortant 29) 		PF00843
(Arena_nucleocap) 		5 THR A 324
LEU A 182
GLY A 243
VAL A  50
VAL A  47
 None
 1.31A 4c9pB-3t5qA:
undetectable		 4c9pB-3t5qA:
19.73
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3uw3 ASPARTATE-SEMIALDEHY
DE DEHYDROGENASE

(Burkholderia
thailandensis) 		PF01118
(Semialdhyde_dh)
PF02774
(Semialdhyde_dhC) 		5 THR A 350
LEU A 146
LEU A 143
GLY A 144
VAL A 308
 None
 1.36A 4c9pB-3uw3A:
undetectable		 4c9pB-3uw3A:
22.35
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3v57 PHYCOERYTHRIN ALPHA
SUBUNIT

(Porphyridium
purpureum) 		PF00502
(Phycobilisome) 		5 THR A 134
LEU A 159
LEU A 156
VAL A  52
VAL A  51
 None
None
None
None
PEB  A 202 (-4.7A)
 1.25A 4c9pB-3v57A:
undetectable		 4c9pB-3v57A:
18.48
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3w9a PUTATIVE
UNCHARACTERIZED
PROTEIN

(Coprinopsis
cinerea) 		no annotation 5 TYR A 179
LEU A 144
GLY A 156
VAL A 202
VAL A 203
 None
 1.08A 4c9pB-3w9aA:
undetectable		 4c9pB-3w9aA:
20.86
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4bms ALCLOHOL
DEHYDROGENASE/SHORT-
CHAIN DEHYDROGENASE

(Ralstonia sp.
DSMZ 6428) 		PF13561
(adh_short_C2) 		5 THR A 135
THR A 118
GLY A  13
VAL A 110
VAL A  61
 NAP  A1250 (-4.1A)
None
NAP  A1250 (-3.1A)
NAP  A1250 (-4.9A)
NAP  A1250 (-3.7A)
 1.35A 4c9pB-4bmsA:
undetectable		 4c9pB-4bmsA:
21.70
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4c9m CYTOCHROME P450

(Novosphingobium
aromaticivorans) 		PF00067
(p450) 		6 TRP A  89
TYR A  98
THR A 103
LEU A 252
GLY A 256
VAL A 404
 None
None
GOL  A1419 (-3.8A)
HEM  A1418 (-4.0A)
HEM  A1418 (-3.8A)
GOL  A1419 (-3.5A)
 1.26A 4c9pB-4c9mA:
70.9		 4c9pB-4c9mA:
99.76
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4c9m CYTOCHROME P450

(Novosphingobium
aromaticivorans) 		PF00067
(p450) 		10 TRP A  89
TYR A  98
THR A 103
THR A 187
LEU A 252
LEU A 255
GLY A 256
VAL A 303
ASP A 305
VAL A 404
 None
None
GOL  A1419 (-3.8A)
None
HEM  A1418 (-4.0A)
GOL  A1419 ( 4.9A)
HEM  A1418 (-3.8A)
GOL  A1419 (-3.9A)
HEM  A1418 (-2.7A)
GOL  A1419 (-3.5A)
 0.26A 4c9pB-4c9mA:
70.9		 4c9pB-4c9mA:
99.76
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4dxy CYTOCHROME P450

(Novosphingobium
aromaticivorans) 		PF00067
(p450) 		5 THR A 101
LEU A 250
GLY A 254
VAL A 301
VAL A 402
 HEM  A 501 ( 4.8A)
HEM  A 501 (-4.3A)
PEG  A 502 (-3.8A)
PEG  A 502 ( 4.5A)
None
 0.66A 4c9pB-4dxyA:
55.2		 4c9pB-4dxyA:
61.00
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4dxy CYTOCHROME P450

(Novosphingobium
aromaticivorans) 		PF00067
(p450) 		5 THR A 101
THR A 185
LEU A 250
LEU A 253
GLY A 254
 HEM  A 501 ( 4.8A)
None
HEM  A 501 (-4.3A)
None
PEG  A 502 (-3.8A)
 1.15A 4c9pB-4dxyA:
55.2		 4c9pB-4dxyA:
61.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4hac MEVALONATE KINASE

(Methanosarcina
mazei) 		PF00288
(GHMP_kinases_N)
PF08544
(GHMP_kinases_C) 		5 THR A 291
THR A 257
LEU A  31
LEU A  92
GLY A   8
 None
 1.23A 4c9pB-4hacA:
undetectable		 4c9pB-4hacA:
23.41
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4k9q BENZOYLFORMATE
DECARBOXYLASE

(Polynucleobacter
necessarius) 		PF00205
(TPP_enzyme_M)
PF02775
(TPP_enzyme_C)
PF02776
(TPP_enzyme_N) 		5 THR A 441
THR A  19
LEU A 412
GLY A 409
VAL A  65
 None
 1.27A 4c9pB-4k9qA:
undetectable		 4c9pB-4k9qA:
22.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4kdw ANTIFREEZE PROTEIN

(Marinomonas
primoryensis) 		no annotation 5 THR A  56
GLY A  32
VAL A  83
ASP A  43
VAL A  45
 None
None
None
GOL  A 208 (-4.4A)
None
 1.21A 4c9pB-4kdwA:
undetectable		 4c9pB-4kdwA:
16.79
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ke4 HYDROXYCINNAMOYL-COA
:SHIKIMATE
HYDROXYCINNAMOYL
TRANSFERASE

(Sorghum bicolor) 		PF02458
(Transferase) 		5 LEU A 295
LEU A 381
GLY A 382
VAL A 417
VAL A 429
 None
 1.36A 4c9pB-4ke4A:
undetectable		 4c9pB-4ke4A:
24.05
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4lk2 PRE-MRNA-PROCESSING
ATP-DEPENDENT RNA
HELICASE PRP5

(Saccharomyces
cerevisiae) 		PF00270
(DEAD)
PF00271
(Helicase_C) 		5 THR A 329
THR A 435
LEU A 404
LEU A 396
VAL A 436
 None
 1.25A 4c9pB-4lk2A:
undetectable		 4c9pB-4lk2A:
21.83
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4m0k ADENINE
PHOSPHORIBOSYLTRANSF
ERASE

(Rhodothermus
marinus) 		PF00156
(Pribosyltran) 		5 THR A 173
LEU A 165
GLY A 161
VAL A 126
ASP A 124
 None
None
None
AMP  A 300 (-3.9A)
AMP  A 300 (-3.0A)
 1.27A 4c9pB-4m0kA:
undetectable		 4c9pB-4m0kA:
21.96
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4mfi SN-GLYCEROL-3-PHOSPH
ATE ABC TRANSPORTER
SUBSTRATE-BINDING
PROTEIN USPB

(Mycobacterium
tuberculosis) 		PF13416
(SBP_bac_8) 		5 THR A 331
LEU A  99
LEU A 309
GLY A 308
VAL A 348
 None
 1.04A 4c9pB-4mfiA:
undetectable		 4c9pB-4mfiA:
23.54
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4mnr PEPTIDOGLYCAN
GLYCOSYLTRANSFERASE

(Eggerthella
lenta) 		PF00905
(Transpeptidase) 		5 THR A 234
LEU A 230
GLY A 199
VAL A 371
VAL A 374
 None
 1.35A 4c9pB-4mnrA:
undetectable		 4c9pB-4mnrA:
22.65
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4n2c PROTEIN-ARGININE
DEIMINASE TYPE-2

(Homo sapiens) 		PF03068
(PAD)
PF08526
(PAD_N)
PF08527
(PAD_M) 		5 THR A  27
LEU A   9
GLY A 110
VAL A  50
VAL A  79
 None
 1.12A 4c9pB-4n2cA:
undetectable		 4c9pB-4n2cA:
20.65
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4n91 TRAP DICARBOXYLATE
TRANSPORTER, DCTP
SUBUNIT

(Anaerococcus
prevotii) 		PF03480
(DctP) 		5 THR A 147
GLY A  48
VAL A  93
ASP A 242
VAL A 244
 None
None
None
GCU  A 401 ( 2.7A)
None
 0.83A 4c9pB-4n91A:
undetectable		 4c9pB-4n91A:
22.03
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4nh0 CELL
DIVISIONFTSK/SPOIIIE

(Thermomonospora
curvata) 		PF01580
(FtsK_SpoIIIE) 		5 THR A1310
LEU A1271
GLY A1270
VAL A1102
ASP A1095
 ATP  A1404 (-4.4A)
None
None
None
None
 1.27A 4c9pB-4nh0A:
undetectable		 4c9pB-4nh0A:
17.35
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4oh0 BETA-LACTAMASE
OXA-58

(Acinetobacter
baumannii) 		PF00905
(Transpeptidase) 		5 THR A  59
LEU A 274
GLY A 275
VAL A 238
VAL A 246
 None
 1.03A 4c9pB-4oh0A:
undetectable		 4c9pB-4oh0A:
22.88
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4okr MICRONEMAL PROTEIN
MIC2

(Toxoplasma
gondii) 		PF00090
(TSP_1)
PF00092
(VWA) 		5 THR A 155
LEU A  80
GLY A 160
VAL A 198
ASP A 194
 None
 1.30A 4c9pB-4okrA:
undetectable		 4c9pB-4okrA:
20.94
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4p99 MPAFP_RII
TETRA-TANDEMER

(Marinomonas
primoryensis) 		no annotation 5 THR A  56
GLY A  32
VAL A  83
ASP A  43
VAL A  45
 None
None
None
CA  A 510 ( 4.9A)
None
 1.21A 4c9pB-4p99A:
undetectable		 4c9pB-4p99A:
23.25
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4p99 MPAFP_RII
TETRA-TANDEMER

(Marinomonas
primoryensis) 		no annotation 5 THR A 160
GLY A 136
VAL A 187
ASP A 147
VAL A 149
 None
None
None
CA  A 507 ( 4.9A)
None
 1.18A 4c9pB-4p99A:
undetectable		 4c9pB-4p99A:
23.25
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4p99 MPAFP_RII
TETRA-TANDEMER

(Marinomonas
primoryensis) 		no annotation 5 THR A 264
GLY A 240
VAL A 291
ASP A 251
VAL A 253
 None
None
None
CA  A 520 ( 4.7A)
None
 1.19A 4c9pB-4p99A:
undetectable		 4c9pB-4p99A:
23.25
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4p99 MPAFP_RII
TETRA-TANDEMER

(Marinomonas
primoryensis) 		no annotation 5 THR A 368
GLY A 344
VAL A 395
ASP A 355
VAL A 357
 None
 1.20A 4c9pB-4p99A:
undetectable		 4c9pB-4p99A:
23.25
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4qbu ZMAA

(Bacillus cereus) 		PF00698
(Acyl_transf_1) 		5 THR A 382
LEU A  98
GLY A 190
VAL A 258
VAL A 352
 None
 1.21A 4c9pB-4qbuA:
undetectable		 4c9pB-4qbuA:
23.98
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4qdk MAGNESIUM-PROTOPORPH
YRIN
O-METHYLTRANSFERASE

(Synechocystis
sp. PCC 6803) 		PF07109
(Mg-por_mtran_C) 		5 THR A 130
LEU A  55
VAL A  87
ASP A  68
VAL A  66
 None
 1.25A 4c9pB-4qdkA:
undetectable		 4c9pB-4qdkA:
21.43
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4r33 NOSL

(Streptomyces
actuosus) 		PF06968
(BATS) 		5 TYR A 242
LEU A 187
GLY A 158
ASP A 195
VAL A 172
 None
 1.07A 4c9pB-4r33A:
undetectable		 4c9pB-4r33A:
23.51
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4rbn SUCROSE
SYNTHASE:GLYCOSYL
TRANSFERASES GROUP 1

(Nitrosomonas
europaea) 		PF00534
(Glycos_transf_1)
PF00862
(Sucrose_synth) 		5 THR A 708
THR A 564
LEU A 580
LEU A 577
GLY A 576
 None
 1.21A 4c9pB-4rbnA:
undetectable		 4c9pB-4rbnA:
23.13
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ut1 FLAGELLAR
HOOK-ASSOCIATED
PROTEIN

(Burkholderia
pseudomallei) 		PF06429
(Flg_bbr_C) 		5 THR A 166
LEU A 278
LEU A 283
GLY A 284
VAL A 159
 EDO  A1639 (-3.2A)
None
None
None
None
 1.32A 4c9pB-4ut1A:
undetectable		 4c9pB-4ut1A:
19.79
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4w8j PESTICIDAL CRYSTAL
PROTEIN CRY1AC

(Bacillus
thuringiensis) 		PF00555
(Endotoxin_M)
PF03944
(Endotoxin_C)
PF03945
(Endotoxin_N) 		5 THR A 264
GLY A 479
VAL A 487
ASP A 497
VAL A 499
 None
 1.19A 4c9pB-4w8jA:
undetectable		 4c9pB-4w8jA:
15.84
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4wrn MALTOSE-BINDING
PERIPLASMIC
PROTEIN,UROMODULIN

(Escherichia
coli;
Homo sapiens) 		PF00100
(Zona_pellucida)
PF13416
(SBP_bac_8) 		5 THR A 589
LEU A 601
LEU A 602
GLY A 641
VAL A 637
 None
 1.25A 4c9pB-4wrnA:
undetectable		 4c9pB-4wrnA:
21.92
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5a3j PUTATIVE
QUINONE-OXIDOREDUCTA
SE HOMOLOG,
CHLOROPLASTIC

(Arabidopsis
thaliana) 		PF08240
(ADH_N)
PF13602
(ADH_zinc_N_2) 		5 THR A  43
THR A 116
LEU A  40
LEU A  38
GLY A  75
 None
 1.33A 4c9pB-5a3jA:
undetectable		 4c9pB-5a3jA:
23.01
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5az3 ABC-TYPE
TRANSPORTER,
PERIPLASMIC
COMPONENT

(Corynebacterium
glutamicum) 		PF01497
(Peripla_BP_2) 		5 THR A  69
THR A 108
LEU A 210
GLY A 207
VAL A 201
 None
 1.35A 4c9pB-5az3A:
undetectable		 4c9pB-5az3A:
23.81
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5bp7 SAM-DEPENDENT
METHYLTRANSFERASE

(Geobacter
sulfurreducens) 		PF13847
(Methyltransf_31) 		5 LEU A  26
LEU A  29
GLY A  30
ASP A  43
VAL A 107
 None
None
None
SAH  A 301 ( 4.5A)
None
 1.17A 4c9pB-5bp7A:
undetectable		 4c9pB-5bp7A:
21.87
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5bp7 SAM-DEPENDENT
METHYLTRANSFERASE

(Geobacter
sulfurreducens) 		PF13847
(Methyltransf_31) 		5 LEU A  26
LEU A  29
GLY A  30
VAL A  41
VAL A 107
 None
 0.80A 4c9pB-5bp7A:
undetectable		 4c9pB-5bp7A:
21.87
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5c3l NANOBODY NB15

(Camelus
dromedarius) 		PF07686
(V-set) 		5 LEU D  79
LEU D  81
VAL D  47
ASP D  50
VAL D  48
 None
 1.25A 4c9pB-5c3lD:
undetectable		 4c9pB-5c3lD:
14.80
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5dfa BETA-GALACTOSIDASE

(Geobacillus
stearothermophilus) 		PF02449
(Glyco_hydro_42)
PF08532
(Glyco_hydro_42M)
PF08533
(Glyco_hydro_42C) 		5 THR A  48
THR A  10
LEU A 359
LEU A 320
VAL A 406
 None
 1.16A 4c9pB-5dfaA:
undetectable		 4c9pB-5dfaA:
20.54
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5dmn HOMOCYSTEINE
S-METHYLTRANSFERASE

(Escherichia
coli) 		PF02574
(S-methyl_trans) 		5 THR A 246
LEU A 239
LEU A 250
GLY A 226
VAL A 213
 None
 1.35A 4c9pB-5dmnA:
undetectable		 4c9pB-5dmnA:
25.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5epe SAM-DEPENDENT
METHYLTRANSFERASE

(Thiobacillus
denitrificans) 		PF13847
(Methyltransf_31) 		5 LEU A  25
LEU A  28
GLY A  29
ASP A  42
VAL A 106
 None
None
None
SAH  A 301 ( 4.5A)
None
 1.20A 4c9pB-5epeA:
undetectable		 4c9pB-5epeA:
20.05
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5epe SAM-DEPENDENT
METHYLTRANSFERASE

(Thiobacillus
denitrificans) 		PF13847
(Methyltransf_31) 		5 LEU A  25
LEU A  28
GLY A  29
VAL A  40
VAL A 106
 None
 0.78A 4c9pB-5epeA:
undetectable		 4c9pB-5epeA:
20.05
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ffp IMMUNITY 23 FAMILY
PROTEIN

(Burkholderia
dolosa) 		PF15593
(Imm42) 		5 LEU A 105
LEU A  29
GLY A  30
VAL A 148
VAL A 151
 None
 1.33A 4c9pB-5ffpA:
undetectable		 4c9pB-5ffpA:
14.92
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5irb RTX-ADHESIN

(Marinomonas
primoryensis) 		no annotation 5 THR A 446
GLY A 422
VAL A 473
ASP A 433
VAL A 435
 None
 1.22A 4c9pB-5irbA:
undetectable		 4c9pB-5irbA:
22.81
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5iw7 RIBOSOME BIOGENESIS
PROTEIN
TSR1,RIBOSOME
BIOGENESIS PROTEIN
TSR1

(Saccharomyces
cerevisiae) 		PF04950
(RIBIOP_C)
PF08142
(AARP2CN) 		5 THR A 663
LEU A 585
LEU A 584
GLY A 583
VAL A 620
 None
 1.33A 4c9pB-5iw7A:
undetectable		 4c9pB-5iw7A:
20.49
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5j7z PUTATIVE SECRETED
ENDOGLYCOSYLCERAMIDA
SE

(Rhodococcus
hoagii) 		PF00150
(Cellulase) 		5 THR A  71
LEU A  66
LEU A 112
VAL A  88
VAL A 126
 None
 1.31A 4c9pB-5j7zA:
undetectable		 4c9pB-5j7zA:
21.99
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5jxm PRIB

(Streptomyces
sp. RM-5-8) 		PF11991
(Trp_DMAT) 		5 THR A  91
LEU A  35
GLY A  36
VAL A 111
VAL A  93
 None
 0.84A 4c9pB-5jxmA:
undetectable		 4c9pB-5jxmA:
24.10
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5k9x TRYPTOPHAN SYNTHASE
ALPHA CHAIN

(Legionella
pneumophila) 		PF00290
(Trp_syntA) 		5 THR A  33
LEU A  99
LEU A  50
GLY A  51
ASP A  80
 None
 1.08A 4c9pB-5k9xA:
undetectable		 4c9pB-5k9xA:
21.91
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5kar ACID
SPHINGOMYELINASE-LIK
E PHOSPHODIESTERASE
3B

(Mus musculus) 		PF00149
(Metallophos) 		5 TYR A 151
LEU A 132
GLY A 133
VAL A 108
VAL A 112
 None
 1.34A 4c9pB-5karA:
undetectable		 4c9pB-5karA:
23.12
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5kju SHIKIMATE
O-HYDROXYCINNAMOYLTR
ANSFERASE

(Arabidopsis
thaliana) 		PF02458
(Transferase) 		5 LEU A 279
LEU A 366
GLY A 367
VAL A 402
VAL A 414
 None
 1.25A 4c9pB-5kjuA:
undetectable		 4c9pB-5kjuA:
22.27
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5lae PEROXISOMAL
N(1)-ACETYL-SPERMINE
/SPERMIDINE
OXIDASE,PEROXISOMAL
N(1)-ACETYL-SPERMINE
/SPERMIDINE OXIDASE

(Mus musculus) 		PF01593
(Amino_oxidase) 		5 THR A 222
THR A 279
GLY A  19
VAL A  35
VAL A  10
 None
 1.18A 4c9pB-5laeA:
undetectable		 4c9pB-5laeA:
23.08
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5mqm GLYCOSYL HYDROLASES
FAMILY 2, SUGAR
BINDING DOMAIN

(Bacteroides
thetaiotaomicron) 		PF17132
(Glyco_hydro_106) 		5 TYR A 954
LEU A 949
LEU A1096
VAL A1021
VAL A1019
 None
 1.30A 4c9pB-5mqmA:
undetectable		 4c9pB-5mqmA:
17.69
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5umx GLYOXALASE/BLEOMYCIN
RESISANCE
PROTEIN/DIOXYGENASE

(Streptomyces
sp. CB03234) 		no annotation 5 LEU A  73
LEU A 116
GLY A 115
VAL A  90
VAL A  92
 None
 1.36A 4c9pB-5umxA:
undetectable		 4c9pB-5umxA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5vev PHOSPHORIBOSYLAMINE-
-GLYCINE LIGASE

(Neisseria
gonorrhoeae) 		PF01071
(GARS_A)
PF02843
(GARS_C)
PF02844
(GARS_N) 		5 THR A 294
THR A  37
GLY A   9
VAL A   5
VAL A  30
 None
 1.36A 4c9pB-5vevA:
undetectable		 4c9pB-5vevA:
23.61
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5vmk BIFUNCTIONAL PROTEIN
GLMU

(Acinetobacter
baumannii) 		PF00132
(Hexapep)
PF12804
(NTP_transf_3)
PF14602
(Hexapep_2) 		5 TRP A  70
THR A  62
THR A  50
LEU A  33
GLY A  34
 None
 1.31A 4c9pB-5vmkA:
undetectable		 4c9pB-5vmkA:
21.29
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5xw3 O-ACETYLSERINE LYASE

(Bacillus
anthracis) 		PF00291
(PALP) 		5 THR A 284
THR A 288
LEU A  30
VAL A 200
VAL A 174
 None
 1.23A 4c9pB-5xw3A:
undetectable		 4c9pB-5xw3A:
22.25
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6cet GATOR COMPLEX
PROTEIN NPRL2

(Homo sapiens) 		no annotation 5 TYR N  43
THR N  24
LEU N  50
VAL N  88
ASP N  38
 None
 1.35A 4c9pB-6cetN:
undetectable		 4c9pB-6cetN:
undetectable