SIMILAR PATTERNS OF AMINO ACIDS FOR 4C9N_B_CAMB1420_0

List of similar pattern of amino acids derived from ASSAM search

Hit pattern: 3D amino acid arrangements similar to known drug binding site

Query pattern: Residues from known binding site for annotated drug that match the hit pattern


(Click link on the last column to view superposed patterns of amino acids in NGL viewer)
(Note that only 3-12 residue patterns can be used for ASSAM searches)
Filter list by:
Hit Macromolecule/
Organism
Pfam Res. Interface HETATM RMSD Dali Z-score Seq. Identity (%) View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1bs0 PROTEIN
(8-AMINO-7-OXONANOAT
E SYNTHASE)


(Escherichia
coli)
PF00155
(Aminotran_1_2)
5 THR A 209
GLY A 242
VAL A 231
ASP A 204
VAL A 232
None
1.34A 4c9nB-1bs0A:
0.0
4c9nB-1bs0A:
22.47
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1d2k CHITINASE 1

(Coccidioides
immitis)
PF00704
(Glyco_hydro_18)
5 TRP A 377
THR A  65
LEU A 404
LEU A 398
VAL A 287
None
1.31A 4c9nB-1d2kA:
0.0
4c9nB-1d2kA:
20.39
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1fsu N-ACETYLGALACTOSAMIN
E-4-SULFATASE


(Homo sapiens)
PF00884
(Sulfatase)
5 THR A 368
THR A 107
LEU A 371
GLY A 101
VAL A 122
None
1.27A 4c9nB-1fsuA:
undetectable
4c9nB-1fsuA:
23.33
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1gso PROTEIN (GLYCINAMIDE
RIBONUCLEOTIDE
SYNTHETASE)


(Escherichia
coli)
PF01071
(GARS_A)
PF02843
(GARS_C)
PF02844
(GARS_N)
5 THR A 296
THR A  37
GLY A   9
VAL A   5
VAL A  30
None
1.33A 4c9nB-1gsoA:
0.0
4c9nB-1gsoA:
22.65
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1hxi PEROXISOME TARGETING
SIGNAL 1 RECEPTOR
PEX5


(Trypanosoma
brucei)
no annotation 5 THR A 392
LEU A 360
LEU A 357
GLY A 356
VAL A 375
None
1.26A 4c9nB-1hxiA:
undetectable
4c9nB-1hxiA:
14.96
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1k7j PROTEIN YCIO

(Escherichia
coli)
PF01300
(Sua5_yciO_yrdC)
5 THR A 118
THR A  98
VAL A 195
ASP A 186
VAL A 184
None
SO4  A 207 ( 4.9A)
None
None
None
1.12A 4c9nB-1k7jA:
0.0
4c9nB-1k7jA:
20.60
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1n0w DNA REPAIR PROTEIN
RAD51 HOMOLOG 1


(Homo sapiens)
PF08423
(Rad51)
5 THR A 298
LEU A 109
LEU A 113
GLY A 116
VAL A 264
None
None
MG  A 401 (-4.2A)
MG  A 401 (-3.8A)
None
1.09A 4c9nB-1n0wA:
undetectable
4c9nB-1n0wA:
21.41
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1q90 APOCYTOCHROME F
CYTOCHROME B6F
COMPLEX SUBUNIT PETL
CYTOCHROME B6F
COMPLEX SUBUNIT PETN


(Chlamydomonas
reinhardtii;
Chlamydomonas
reinhardtii;
Chlamydomonas
reinhardtii)
PF01333
(Apocytochr_F_C)
PF16639
(Apocytochr_F_N)
PF05115
(PetL)
PF03742
(PetN)
5 TRP N  93
LEU L  23
LEU L  19
GLY L  20
VAL A 267
None
1.31A 4c9nB-1q90N:
undetectable
4c9nB-1q90N:
8.71
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1s4d UROPORPHYRIN-III
C-METHYLTRANSFERASE


(Pseudomonas
denitrificans
(nomen
rejiciendum))
PF00590
(TP_methylase)
5 TYR A 183
THR A 130
LEU A 136
VAL A 152
VAL A 179
SAH  A1501 (-4.8A)
SAH  A1501 ( 3.6A)
None
None
None
1.25A 4c9nB-1s4dA:
undetectable
4c9nB-1s4dA:
21.85
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1xb7 STEROID HORMONE
RECEPTOR ERR1


(Homo sapiens)
PF00104
(Hormone_recep)
5 LEU A 398
LEU A 401
GLY A 402
VAL A 369
VAL A 366
None
1.10A 4c9nB-1xb7A:
0.0
4c9nB-1xb7A:
21.66
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1y1p ALDEHYDE REDUCTASE
II


(Sporidiobolus
salmonicolor)
PF01370
(Epimerase)
5 THR A 312
LEU A 316
LEU A 319
GLY A 326
VAL A 248
None
1.28A 4c9nB-1y1pA:
undetectable
4c9nB-1y1pA:
21.08
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1z7d ORNITHINE
AMINOTRANSFERASE


(Plasmodium
yoelii)
PF00202
(Aminotran_3)
5 THR A 385
THR A 381
LEU A 348
GLY A 203
VAL A 377
None
1.20A 4c9nB-1z7dA:
undetectable
4c9nB-1z7dA:
23.35
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2e7u GLUTAMATE-1-SEMIALDE
HYDE 2,1-AMINOMUTASE


(Thermus
thermophilus)
PF00202
(Aminotran_3)
5 TRP A 394
LEU A 417
LEU A 420
VAL A 350
VAL A 359
None
1.33A 4c9nB-2e7uA:
undetectable
4c9nB-2e7uA:
23.82
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2m56 CAMPHOR
5-MONOOXYGENASE


(Pseudomonas
putida)
PF00067
(p450)
5 TYR A  96
THR A 101
LEU A 244
GLY A 248
VAL A 295
CAM  A 502 (-4.5A)
HEM  A 501 (-2.9A)
HEM  A 501 (-4.5A)
HEM  A 501 (-3.9A)
HEM  A 501 (-4.6A)
1.09A 4c9nB-2m56A:
57.7
4c9nB-2m56A:
44.21
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2m56 CAMPHOR
5-MONOOXYGENASE


(Pseudomonas
putida)
PF00067
(p450)
8 TYR A  96
THR A 101
THR A 185
LEU A 244
GLY A 248
VAL A 295
ASP A 297
VAL A 396
CAM  A 502 (-4.5A)
HEM  A 501 (-2.9A)
None
HEM  A 501 (-4.5A)
HEM  A 501 (-3.9A)
HEM  A 501 (-4.6A)
HEM  A 501 (-2.8A)
None
0.58A 4c9nB-2m56A:
57.7
4c9nB-2m56A:
44.21
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2oga TRANSAMINASE

(Streptomyces
venezuelae)
PF01041
(DegT_DnrJ_EryC1)
5 THR A 206
LEU A 218
GLY A  77
VAL A 162
VAL A 184
None
1.26A 4c9nB-2ogaA:
undetectable
4c9nB-2ogaA:
24.68
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2p3j VP4

(Rotavirus A)
PF00426
(VP4_haemagglut)
5 THR A 191
THR A 176
LEU A 103
GLY A  95
VAL A 167
None
1.20A 4c9nB-2p3jA:
undetectable
4c9nB-2p3jA:
14.36
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2pfy PUTATIVE EXPORTED
PROTEIN


(Bordetella
pertussis)
PF03480
(DctP)
5 THR A  99
LEU A 295
LEU A 296
ASP A  80
VAL A  82
None
1.24A 4c9nB-2pfyA:
undetectable
4c9nB-2pfyA:
20.56
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2qa1 POLYKETIDE OXYGENASE
PGAE


(Streptomyces
sp. PGA64)
PF01494
(FAD_binding_3)
5 LEU A  17
LEU A 298
GLY A 299
VAL A 306
VAL A 305
None
1.16A 4c9nB-2qa1A:
undetectable
4c9nB-2qa1A:
23.06
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2rq6 ATP SYNTHASE EPSILON
CHAIN


(Thermosynechococcus
elongatus)
PF00401
(ATP-synt_DE)
PF02823
(ATP-synt_DE_N)
5 THR A  42
LEU A  24
LEU A  31
GLY A  32
VAL A  69
None
1.18A 4c9nB-2rq6A:
undetectable
4c9nB-2rq6A:
15.12
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2rq7 ATP SYNTHASE EPSILON
CHAIN


(Spinacia
oleracea;
Thermosynechococcus
elongatus)
PF00401
(ATP-synt_DE)
PF02823
(ATP-synt_DE_N)
5 LEU A  24
LEU A  31
GLY A  32
VAL A  74
VAL A  69
None
1.28A 4c9nB-2rq7A:
undetectable
4c9nB-2rq7A:
14.01
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2wu0 PHYTASE

(Klebsiella
pneumoniae)
PF00328
(His_Phos_2)
5 THR A 104
GLY A  58
VAL A  65
ASP A 110
VAL A  64
None
1.04A 4c9nB-2wu0A:
undetectable
4c9nB-2wu0A:
24.01
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2yg8 DNA-3-METHYLADENINE
GLYCOSIDASE II,
PUTATIVE


(Deinococcus
radiodurans)
PF00730
(HhH-GPD)
5 THR A 197
GLY A 183
VAL A  41
ASP A  39
VAL A  45
None
None
GOL  A1228 (-4.2A)
None
None
1.26A 4c9nB-2yg8A:
undetectable
4c9nB-2yg8A:
22.49
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2z01 PHOSPHORIBOSYLFORMYL
GLYCINAMIDINE
CYCLO-LIGASE


(Geobacillus
kaustophilus)
PF00586
(AIRS)
PF02769
(AIRS_C)
5 LEU A  74
LEU A 206
GLY A 218
VAL A 194
VAL A 198
None
1.29A 4c9nB-2z01A:
undetectable
4c9nB-2z01A:
25.98
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2zwv PROBABLE RIBOSOMAL
RNA SMALL SUBUNIT
METHYLTRANSFERASE


(Thermus
thermophilus)
PF05175
(MTS)
5 LEU A 220
LEU A 223
VAL A 258
ASP A 239
VAL A 237
None
None
None
SAH  A 376 ( 4.2A)
None
1.17A 4c9nB-2zwvA:
undetectable
4c9nB-2zwvA:
25.16
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3asa LL-DIAMINOPIMELATE
AMINOTRANSFERASE


(Chlamydia
trachomatis)
PF00155
(Aminotran_1_2)
5 TRP A 247
THR A 207
LEU A 292
LEU A 289
GLY A 288
None
0.82A 4c9nB-3asaA:
undetectable
4c9nB-3asaA:
23.58
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3b3d PUTATIVE MORPHINE
DEHYDROGENASE


(Bacillus
subtilis)
PF00248
(Aldo_ket_red)
5 THR A  50
LEU A 107
LEU A 105
GLY A  61
VAL A  24
None
1.10A 4c9nB-3b3dA:
undetectable
4c9nB-3b3dA:
22.99
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3dla GLUTAMINE-DEPENDENT
NAD(+) SYNTHETASE


(Mycobacterium
tuberculosis)
PF00795
(CN_hydrolase)
PF02540
(NAD_synthase)
5 TYR A   7
THR A 276
LEU A 310
LEU A 166
VAL A 196
None
1.26A 4c9nB-3dlaA:
undetectable
4c9nB-3dlaA:
21.12
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3f9t L-TYROSINE
DECARBOXYLASE MFNA


(Methanocaldococcus
jannaschii)
PF00282
(Pyridoxal_deC)
5 LEU A  99
LEU A 102
GLY A 138
ASP A 206
VAL A 127
None
None
None
PLP  A 500 (-2.6A)
None
1.30A 4c9nB-3f9tA:
undetectable
4c9nB-3f9tA:
21.17
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3fha ENDO-BETA-N-ACETYLGL
UCOSAMINIDASE


(Glutamicibacter
protophormiae)
PF03644
(Glyco_hydro_85)
5 TRP A 282
LEU A  55
LEU A 296
GLY A 297
VAL A 271
None
1.20A 4c9nB-3fhaA:
undetectable
4c9nB-3fhaA:
21.71
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3g1u ADENOSYLHOMOCYSTEINA
SE


(Leishmania
major)
PF00670
(AdoHcyase_NAD)
PF05221
(AdoHcyase)
5 THR A 274
LEU A 191
GLY A 226
VAL A 240
VAL A 217
None
1.35A 4c9nB-3g1uA:
undetectable
4c9nB-3g1uA:
22.15
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3jq3 LOMBRICINE KINASE

(Urechis caupo)
PF00217
(ATP-gua_Ptrans)
PF02807
(ATP-gua_PtransN)
5 THR A 120
LEU A 244
LEU A  98
GLY A 241
VAL A 337
None
1.30A 4c9nB-3jq3A:
undetectable
4c9nB-3jq3A:
22.63
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3mwt NUCLEOPROTEIN

(Lassa
mammarenavirus)
PF00843
(Arena_nucleocap)
PF17290
(Arena_ncap_C)
5 THR A 324
LEU A 182
GLY A 243
VAL A  50
VAL A  47
None
1.34A 4c9nB-3mwtA:
undetectable
4c9nB-3mwtA:
23.01
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ndn O-SUCCINYLHOMOSERINE
SULFHYDRYLASE


(Mycobacterium
tuberculosis)
PF01053
(Cys_Met_Meta_PP)
5 THR A 181
THR A 166
LEU A 193
GLY A 205
ASP A 176
None
1.13A 4c9nB-3ndnA:
undetectable
4c9nB-3ndnA:
20.98
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3noq THIJ/PFPI FAMILY
PROTEIN


(Pseudomonas
fluorescens)
PF01965
(DJ-1_PfpI)
5 THR A 120
LEU A 128
LEU A 131
GLY A 108
VAL A  74
None
1.24A 4c9nB-3noqA:
undetectable
4c9nB-3noqA:
20.32
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3pzr ASPARTATE-SEMIALDEHY
DE DEHYDROGENASE


(Vibrio cholerae)
PF01118
(Semialdhyde_dh)
PF02774
(Semialdhyde_dhC)
5 THR A 346
LEU A 146
LEU A 143
GLY A 144
VAL A 304
None
1.20A 4c9nB-3pzrA:
undetectable
4c9nB-3pzrA:
22.20
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3sh5 LG3 PEPTIDE

(Homo sapiens)
PF00054
(Laminin_G_1)
5 THR A  40
LEU A  73
LEU A  68
GLY A  67
VAL A 160
None
1.16A 4c9nB-3sh5A:
undetectable
4c9nB-3sh5A:
22.44
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3t4c 2-DEHYDRO-3-DEOXYPHO
SPHOOCTONATE
ALDOLASE 1


(Burkholderia
ambifaria)
PF00793
(DAHP_synth_1)
5 TYR A  49
THR A  29
THR A  89
LEU A  76
GLY A  72
None
0.92A 4c9nB-3t4cA:
undetectable
4c9nB-3t4cA:
22.51
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3t5q NUCLEOPROTEIN

(Mopeia Lassa
virus
reassortant 29)
PF00843
(Arena_nucleocap)
5 THR A 324
LEU A 182
GLY A 243
VAL A  50
VAL A  47
None
1.35A 4c9nB-3t5qA:
undetectable
4c9nB-3t5qA:
19.73
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3uw3 ASPARTATE-SEMIALDEHY
DE DEHYDROGENASE


(Burkholderia
thailandensis)
PF01118
(Semialdhyde_dh)
PF02774
(Semialdhyde_dhC)
5 THR A 350
LEU A 146
LEU A 143
GLY A 144
VAL A 308
None
1.28A 4c9nB-3uw3A:
undetectable
4c9nB-3uw3A:
22.97
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3w9a PUTATIVE
UNCHARACTERIZED
PROTEIN


(Coprinopsis
cinerea)
no annotation 5 TYR A 179
LEU A 144
GLY A 156
VAL A 202
VAL A 203
None
1.09A 4c9nB-3w9aA:
undetectable
4c9nB-3w9aA:
16.55
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3wvr PGM1

(Streptomyces
cirratus)
no annotation 5 TYR A  50
LEU A 388
GLY A 396
VAL A 350
VAL A 346
None
1.33A 4c9nB-3wvrA:
undetectable
4c9nB-3wvrA:
25.20
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4bms ALCLOHOL
DEHYDROGENASE/SHORT-
CHAIN DEHYDROGENASE


(Ralstonia sp.
DSMZ 6428)
PF13561
(adh_short_C2)
5 THR A 135
THR A 118
GLY A  13
VAL A 110
VAL A  61
NAP  A1250 (-4.1A)
None
NAP  A1250 (-3.1A)
NAP  A1250 (-4.9A)
NAP  A1250 (-3.7A)
1.35A 4c9nB-4bmsA:
undetectable
4c9nB-4bmsA:
21.70
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4c7v TRANSKETOLASE

(Lactobacillus
salivarius)
PF00456
(Transketolase_N)
PF02779
(Transket_pyr)
PF02780
(Transketolase_C)
5 THR A  44
THR A  12
LEU A  80
VAL A   5
ASP A   6
None
1.16A 4c9nB-4c7vA:
undetectable
4c9nB-4c7vA:
21.65
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4c9m CYTOCHROME P450

(Novosphingobium
aromaticivorans)
PF00067
(p450)
7 TRP A  89
TYR A  98
THR A 103
LEU A 252
LEU A 255
GLY A 256
VAL A 303
None
None
GOL  A1419 (-3.8A)
HEM  A1418 (-4.0A)
GOL  A1419 ( 4.9A)
HEM  A1418 (-3.8A)
GOL  A1419 (-3.9A)
1.16A 4c9nB-4c9mA:
70.8
4c9nB-4c9mA:
99.76
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4c9m CYTOCHROME P450

(Novosphingobium
aromaticivorans)
PF00067
(p450)
10 TRP A  89
TYR A  98
THR A 103
THR A 187
LEU A 252
LEU A 255
GLY A 256
VAL A 303
ASP A 305
VAL A 404
None
None
GOL  A1419 (-3.8A)
None
HEM  A1418 (-4.0A)
GOL  A1419 ( 4.9A)
HEM  A1418 (-3.8A)
GOL  A1419 (-3.9A)
HEM  A1418 (-2.7A)
GOL  A1419 (-3.5A)
0.17A 4c9nB-4c9mA:
70.8
4c9nB-4c9mA:
99.76
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4dxy CYTOCHROME P450

(Novosphingobium
aromaticivorans)
PF00067
(p450)
5 THR A 101
LEU A 250
GLY A 254
VAL A 301
VAL A 402
HEM  A 501 ( 4.8A)
HEM  A 501 (-4.3A)
PEG  A 502 (-3.8A)
PEG  A 502 ( 4.5A)
None
0.76A 4c9nB-4dxyA:
55.0
4c9nB-4dxyA:
61.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4gj1 1-(5-PHOSPHORIBOSYL)
-5-[(5-PHOSPHORIBOSY
LAMINO)METHYLIDENEAM
INO]
IMIDAZOLE-4-CARBOXAM
IDE ISOMERASE


(Campylobacter
jejuni)
PF00977
(His_biosynth)
5 THR A   2
LEU A 241
LEU A 211
VAL A 184
VAL A 182
None
1.27A 4c9nB-4gj1A:
undetectable
4c9nB-4gj1A:
20.51
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4hac MEVALONATE KINASE

(Methanosarcina
mazei)
PF00288
(GHMP_kinases_N)
PF08544
(GHMP_kinases_C)
5 THR A 291
THR A 257
LEU A  31
LEU A  92
GLY A   8
None
1.29A 4c9nB-4hacA:
undetectable
4c9nB-4hacA:
23.41
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4j7b POLO-LIKE KINASE

(Danio rerio)
PF00069
(Pkinase)
5 THR A 146
THR A 229
LEU A 168
LEU A 165
GLY A 166
None
1.34A 4c9nB-4j7bA:
undetectable
4c9nB-4j7bA:
21.86
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4k9q BENZOYLFORMATE
DECARBOXYLASE


(Polynucleobacter
necessarius)
PF00205
(TPP_enzyme_M)
PF02775
(TPP_enzyme_C)
PF02776
(TPP_enzyme_N)
5 THR A 441
THR A  19
LEU A 412
GLY A 409
VAL A  65
None
1.28A 4c9nB-4k9qA:
undetectable
4c9nB-4k9qA:
22.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4kdw ANTIFREEZE PROTEIN

(Marinomonas
primoryensis)
no annotation 5 THR A  56
GLY A  32
VAL A  83
ASP A  43
VAL A  45
None
None
None
GOL  A 208 (-4.4A)
None
1.13A 4c9nB-4kdwA:
undetectable
4c9nB-4kdwA:
16.46
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ke4 HYDROXYCINNAMOYL-COA
:SHIKIMATE
HYDROXYCINNAMOYL
TRANSFERASE


(Sorghum bicolor)
PF02458
(Transferase)
5 LEU A 295
LEU A 381
GLY A 382
VAL A 417
VAL A 429
None
1.33A 4c9nB-4ke4A:
undetectable
4c9nB-4ke4A:
24.51
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4krg PHOSPHOETHANOLAMINE
N-METHYLTRANSFERASE
1


(Haemonchus
contortus)
PF08241
(Methyltransf_11)
5 LEU A  44
LEU A  47
VAL A  76
ASP A  57
VAL A  55
None
1.25A 4c9nB-4krgA:
undetectable
4c9nB-4krgA:
21.65
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4le6 ORGANOPHOSPHORUS
HYDROLASE


(Pseudomonas
pseudoalcaligenes)
PF00753
(Lactamase_B)
5 THR A 231
THR A 134
LEU A 220
LEU A 214
VAL A 101
EDO  A 403 (-3.2A)
None
EDO  A 403 ( 4.8A)
None
None
1.18A 4c9nB-4le6A:
undetectable
4c9nB-4le6A:
21.91
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4m0k ADENINE
PHOSPHORIBOSYLTRANSF
ERASE


(Rhodothermus
marinus)
PF00156
(Pribosyltran)
5 THR A 173
LEU A 165
GLY A 161
VAL A 126
ASP A 124
None
None
None
AMP  A 300 (-3.9A)
AMP  A 300 (-3.0A)
1.28A 4c9nB-4m0kA:
undetectable
4c9nB-4m0kA:
21.96
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4mfi SN-GLYCEROL-3-PHOSPH
ATE ABC TRANSPORTER
SUBSTRATE-BINDING
PROTEIN USPB


(Mycobacterium
tuberculosis)
PF13416
(SBP_bac_8)
5 THR A 331
LEU A  99
LEU A 309
GLY A 308
VAL A 348
None
1.01A 4c9nB-4mfiA:
undetectable
4c9nB-4mfiA:
23.54
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4n1a CELL
DIVISIONFTSK/SPOIIIE


(Thermomonospora
curvata)
PF01580
(FtsK_SpoIIIE)
5 THR A1310
LEU A1271
GLY A1270
VAL A1102
ASP A1095
ATP  A1402 (-4.7A)
None
None
None
None
1.28A 4c9nB-4n1aA:
undetectable
4c9nB-4n1aA:
23.93
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4n91 TRAP DICARBOXYLATE
TRANSPORTER, DCTP
SUBUNIT


(Anaerococcus
prevotii)
PF03480
(DctP)
5 THR A 147
GLY A  48
VAL A  93
ASP A 242
VAL A 244
None
None
None
GCU  A 401 ( 2.7A)
None
0.87A 4c9nB-4n91A:
undetectable
4c9nB-4n91A:
22.03
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4nh0 CELL
DIVISIONFTSK/SPOIIIE


(Thermomonospora
curvata)
PF01580
(FtsK_SpoIIIE)
5 THR A1310
LEU A1271
GLY A1270
VAL A1102
ASP A1095
ATP  A1404 (-4.4A)
None
None
None
None
1.30A 4c9nB-4nh0A:
undetectable
4c9nB-4nh0A:
17.44
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4oh0 BETA-LACTAMASE
OXA-58


(Acinetobacter
baumannii)
PF00905
(Transpeptidase)
5 THR A  59
LEU A 274
GLY A 275
VAL A 238
VAL A 246
None
1.05A 4c9nB-4oh0A:
undetectable
4c9nB-4oh0A:
22.88
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4p49 ANTIBODY SCFV B8

(Gallus gallus)
PF07686
(V-set)
5 TYR A 216
THR A 214
LEU A 165
GLY A 164
ASP A  36
None
1.35A 4c9nB-4p49A:
undetectable
4c9nB-4p49A:
22.41
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4p99 MPAFP_RII
TETRA-TANDEMER


(Marinomonas
primoryensis)
no annotation 5 THR A  56
GLY A  32
VAL A  83
ASP A  43
VAL A  45
None
None
None
CA  A 510 ( 4.9A)
None
1.14A 4c9nB-4p99A:
undetectable
4c9nB-4p99A:
23.08
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4p99 MPAFP_RII
TETRA-TANDEMER


(Marinomonas
primoryensis)
no annotation 5 THR A 160
GLY A 136
VAL A 187
ASP A 147
VAL A 149
None
None
None
CA  A 507 ( 4.9A)
None
1.11A 4c9nB-4p99A:
undetectable
4c9nB-4p99A:
23.08
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4p99 MPAFP_RII
TETRA-TANDEMER


(Marinomonas
primoryensis)
no annotation 5 THR A 264
GLY A 240
VAL A 291
ASP A 251
VAL A 253
None
None
None
CA  A 520 ( 4.7A)
None
1.12A 4c9nB-4p99A:
undetectable
4c9nB-4p99A:
23.08
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4p99 MPAFP_RII
TETRA-TANDEMER


(Marinomonas
primoryensis)
no annotation 5 THR A 368
GLY A 344
VAL A 395
ASP A 355
VAL A 357
None
1.13A 4c9nB-4p99A:
undetectable
4c9nB-4p99A:
23.08
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ptz FMN REDUCTASE SSUE

(Escherichia
coli)
no annotation 5 THR C 166
LEU C 104
LEU C 102
GLY C 135
ASP C 161
None
1.29A 4c9nB-4ptzC:
undetectable
4c9nB-4ptzC:
19.86
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4qbu ZMAA

(Bacillus cereus)
PF00698
(Acyl_transf_1)
5 THR A 382
LEU A  98
GLY A 190
VAL A 258
VAL A 352
None
1.21A 4c9nB-4qbuA:
undetectable
4c9nB-4qbuA:
23.68
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4qyr AT-LESS POLYKETIDE
SYNTHASE


(Streptomyces
platensis)
PF00109
(ketoacyl-synt)
PF02801
(Ketoacyl-synt_C)
PF16197
(KAsynt_C_assoc)
5 THR A3057
LEU A2995
LEU A3044
GLY A3045
VAL A3048
None
1.26A 4c9nB-4qyrA:
undetectable
4c9nB-4qyrA:
23.99
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4r33 NOSL

(Streptomyces
actuosus)
PF06968
(BATS)
5 TYR A 242
LEU A 187
GLY A 158
ASP A 195
VAL A 172
None
1.04A 4c9nB-4r33A:
undetectable
4c9nB-4r33A:
23.30
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4rbn SUCROSE
SYNTHASE:GLYCOSYL
TRANSFERASES GROUP 1


(Nitrosomonas
europaea)
PF00534
(Glycos_transf_1)
PF00862
(Sucrose_synth)
5 THR A 708
THR A 564
LEU A 580
LEU A 577
GLY A 576
None
1.14A 4c9nB-4rbnA:
undetectable
4c9nB-4rbnA:
23.39
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4wrn MALTOSE-BINDING
PERIPLASMIC
PROTEIN,UROMODULIN


(Escherichia
coli;
Homo sapiens)
PF00100
(Zona_pellucida)
PF13416
(SBP_bac_8)
5 THR A 589
LEU A 601
LEU A 602
GLY A 641
VAL A 637
None
1.25A 4c9nB-4wrnA:
undetectable
4c9nB-4wrnA:
21.99
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4x4j PUTATIVE OXYGENASE

(Amycolatopsis
orientalis)
PF01494
(FAD_binding_3)
5 LEU A  17
LEU A 298
GLY A 299
VAL A 306
VAL A 305
None
1.15A 4c9nB-4x4jA:
undetectable
4c9nB-4x4jA:
22.96
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5a5t EUKARYOTIC
TRANSLATION
INITIATION FACTOR 3
SUBUNIT K


(Oryctolagus
cuniculus)
PF10075
(CSN8_PSD8_EIF3K)
5 LEU K 165
LEU K 162
GLY K 163
ASP K 136
VAL K 138
None
1.31A 4c9nB-5a5tK:
undetectable
4c9nB-5a5tK:
20.14
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5az3 ABC-TYPE
TRANSPORTER,
PERIPLASMIC
COMPONENT


(Corynebacterium
glutamicum)
PF01497
(Peripla_BP_2)
5 THR A  69
THR A 108
LEU A 210
GLY A 207
VAL A 201
None
1.34A 4c9nB-5az3A:
undetectable
4c9nB-5az3A:
23.92
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5bp7 SAM-DEPENDENT
METHYLTRANSFERASE


(Geobacter
sulfurreducens)
PF13847
(Methyltransf_31)
5 LEU A  26
LEU A  29
GLY A  30
ASP A  43
VAL A 107
None
None
None
SAH  A 301 ( 4.5A)
None
1.06A 4c9nB-5bp7A:
undetectable
4c9nB-5bp7A:
21.89
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5bp7 SAM-DEPENDENT
METHYLTRANSFERASE


(Geobacter
sulfurreducens)
PF13847
(Methyltransf_31)
5 LEU A  26
LEU A  29
GLY A  30
VAL A  41
VAL A 107
None
0.70A 4c9nB-5bp7A:
undetectable
4c9nB-5bp7A:
21.89
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5d8m METAGENOMIC CARBOXYL
ESTERASE MGS0156


(uncultured
organism)
no annotation 5 THR A 252
THR A 230
LEU A 242
VAL A 198
VAL A 166
None
1.29A 4c9nB-5d8mA:
undetectable
4c9nB-5d8mA:
23.46
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5dfa BETA-GALACTOSIDASE

(Geobacillus
stearothermophilus)
PF02449
(Glyco_hydro_42)
PF08532
(Glyco_hydro_42M)
PF08533
(Glyco_hydro_42C)
5 THR A  48
THR A  10
LEU A 359
LEU A 320
VAL A 406
None
1.19A 4c9nB-5dfaA:
undetectable
4c9nB-5dfaA:
20.40
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5dmn HOMOCYSTEINE
S-METHYLTRANSFERASE


(Escherichia
coli)
PF02574
(S-methyl_trans)
5 THR A 246
LEU A 239
LEU A 250
GLY A 226
VAL A 213
None
1.29A 4c9nB-5dmnA:
undetectable
4c9nB-5dmnA:
25.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5epe SAM-DEPENDENT
METHYLTRANSFERASE


(Thiobacillus
denitrificans)
PF13847
(Methyltransf_31)
5 LEU A  25
LEU A  28
GLY A  29
ASP A  42
VAL A 106
None
None
None
SAH  A 301 ( 4.5A)
None
1.10A 4c9nB-5epeA:
undetectable
4c9nB-5epeA:
21.75
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5epe SAM-DEPENDENT
METHYLTRANSFERASE


(Thiobacillus
denitrificans)
PF13847
(Methyltransf_31)
5 LEU A  25
LEU A  28
GLY A  29
VAL A  40
VAL A 106
None
0.68A 4c9nB-5epeA:
undetectable
4c9nB-5epeA:
21.75
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5epe SAM-DEPENDENT
METHYLTRANSFERASE


(Thiobacillus
denitrificans)
PF13847
(Methyltransf_31)
5 LEU A  28
LEU A  32
GLY A  29
ASP A  42
VAL A  40
None
None
None
SAH  A 301 ( 4.5A)
None
1.34A 4c9nB-5epeA:
undetectable
4c9nB-5epeA:
21.75
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ffp IMMUNITY 23 FAMILY
PROTEIN


(Burkholderia
dolosa)
PF15593
(Imm42)
5 LEU A 105
LEU A  29
GLY A  30
VAL A 148
VAL A 151
None
1.32A 4c9nB-5ffpA:
undetectable
4c9nB-5ffpA:
14.92
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5irb RTX-ADHESIN

(Marinomonas
primoryensis)
no annotation 5 THR A 446
GLY A 422
VAL A 473
ASP A 433
VAL A 435
None
1.14A 4c9nB-5irbA:
undetectable
4c9nB-5irbA:
23.56
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5iw7 RIBOSOME BIOGENESIS
PROTEIN
TSR1,RIBOSOME
BIOGENESIS PROTEIN
TSR1


(Saccharomyces
cerevisiae)
PF04950
(RIBIOP_C)
PF08142
(AARP2CN)
5 THR A 663
LEU A 585
LEU A 584
GLY A 583
VAL A 620
None
1.33A 4c9nB-5iw7A:
undetectable
4c9nB-5iw7A:
20.72
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5j7z PUTATIVE SECRETED
ENDOGLYCOSYLCERAMIDA
SE


(Rhodococcus
hoagii)
PF00150
(Cellulase)
5 THR A  71
LEU A  66
LEU A 112
VAL A  88
VAL A 126
None
1.31A 4c9nB-5j7zA:
undetectable
4c9nB-5j7zA:
21.99
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5jxm PRIB

(Streptomyces
sp. RM-5-8)
PF11991
(Trp_DMAT)
5 THR A  91
LEU A  35
GLY A  36
VAL A 111
VAL A  93
None
0.80A 4c9nB-5jxmA:
undetectable
4c9nB-5jxmA:
23.87
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5k8g ANTIFREEZE PROTEIN

(Marinomonas
primoryensis)
no annotation 5 THR A  56
GLY A  32
VAL A  84
ASP A  43
VAL A  45
None
None
None
CA  A 615 ( 4.7A)
None
1.15A 4c9nB-5k8gA:
undetectable
4c9nB-5k8gA:
23.94
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5k9x TRYPTOPHAN SYNTHASE
ALPHA CHAIN


(Legionella
pneumophila)
PF00290
(Trp_syntA)
5 THR A  33
LEU A  99
LEU A  50
GLY A  51
ASP A  80
None
1.06A 4c9nB-5k9xA:
undetectable
4c9nB-5k9xA:
21.91
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5kar ACID
SPHINGOMYELINASE-LIK
E PHOSPHODIESTERASE
3B


(Mus musculus)
PF00149
(Metallophos)
5 TYR A 151
LEU A 132
GLY A 133
VAL A 108
VAL A 112
None
1.33A 4c9nB-5karA:
undetectable
4c9nB-5karA:
23.12
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5kju SHIKIMATE
O-HYDROXYCINNAMOYLTR
ANSFERASE


(Arabidopsis
thaliana)
PF02458
(Transferase)
5 LEU A 279
LEU A 366
GLY A 367
VAL A 402
VAL A 414
None
1.21A 4c9nB-5kjuA:
undetectable
4c9nB-5kjuA:
22.27
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5lq3 CMEB

(Campylobacter
jejuni)
PF00873
(ACR_tran)
5 LEU A 932
GLY A 931
VAL A 449
ASP A 410
VAL A 481
None
1.35A 4c9nB-5lq3A:
undetectable
4c9nB-5lq3A:
16.97
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5nfh METHIONYL-TRNA
SYNTHETASE, PUTATIVE


(Trypanosoma
brucei)
no annotation 5 THR A 710
LEU A 606
LEU A 610
GLY A 611
VAL A 723
None
1.06A 4c9nB-5nfhA:
undetectable
4c9nB-5nfhA:
21.67
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5t5i TUNGSTEN
FORMYLMETHANOFURAN
DEHYDROGENASE
SUBUNIT B
TUNGSTEN-CONTAINING
FORMYLMETHANOFURAN
DEHYDROGENASE 2
SUBUNIT C


(Methanothermobacter
sp. CaT2;
Methanothermobacter
wolfeii)
PF00384
(Molybdopterin)
PF01493
(GXGXG)
5 TYR B 207
THR B 268
LEU C 219
GLY C 221
VAL B 227
None
1.29A 4c9nB-5t5iB:
undetectable
4c9nB-5t5iB:
22.80
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5umx GLYOXALASE/BLEOMYCIN
RESISANCE
PROTEIN/DIOXYGENASE


(Streptomyces
sp. CB03234)
no annotation 5 LEU A  73
LEU A 116
GLY A 115
VAL A  90
VAL A  92
None
1.33A 4c9nB-5umxA:
undetectable
4c9nB-5umxA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5vev PHOSPHORIBOSYLAMINE-
-GLYCINE LIGASE


(Neisseria
gonorrhoeae)
PF01071
(GARS_A)
PF02843
(GARS_C)
PF02844
(GARS_N)
5 THR A 294
THR A  37
GLY A   9
VAL A   5
VAL A  30
None
1.32A 4c9nB-5vevA:
undetectable
4c9nB-5vevA:
23.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5vxz GROWTH
ARREST-SPECIFIC
PROTEIN 6


(Homo sapiens)
PF00054
(Laminin_G_1)
PF02210
(Laminin_G_2)
5 TYR A 492
THR A 621
LEU A 525
LEU A 535
VAL A 579
None
1.31A 4c9nB-5vxzA:
undetectable
4c9nB-5vxzA:
23.89
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6cet GATOR COMPLEX
PROTEIN NPRL2


(Homo sapiens)
no annotation 5 TYR N  43
THR N  24
LEU N  50
VAL N  88
ASP N  38
None
1.32A 4c9nB-6cetN:
undetectable
4c9nB-6cetN:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6fm7 BETA-LACTAMASE

(Aeromonas
enteropelogenes)
no annotation 5 TYR A  74
THR A 175
LEU A 171
LEU A 164
GLY A 165
None
1.29A 4c9nB-6fm7A:
undetectable
4c9nB-6fm7A:
undetectable