SIMILAR PATTERNS OF AMINO ACIDS FOR 4C9L_B_CAMB1419_0
List of similar pattern of amino acids derived from ASSAM searchHit | Macromolecule/ Organism |
Pfam | Res. | Interface | HETATM | RMSD | Dali Z-score | Seq. Identity (%) | View | Dock | |
---|---|---|---|---|---|---|---|---|---|---|---|
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 1bhy | P64K (Neisseriameningitidis) |
PF02852(Pyr_redox_dim)PF07992(Pyr_redox_2) | 5 | ILE A 435GLY A 455VAL A 424ILE A 422VAL A 442 | None | 1.02A | 4c9lB-1bhyA:0.0 | 4c9lB-1bhyA:22.24 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 1cf2 | PROTEIN(GLYCERALDEHYDE-3-PHOSPHATEDEHYDROGENASE) (Methanothermusfervidus) |
no annotation | 5 | ILE P 261GLY P 144THR P 148ILE P 247VAL P 246 | None | 0.92A | 4c9lB-1cf2P:undetectable | 4c9lB-1cf2P:22.85 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 1e9y | UREASE SUBUNIT BETA (Helicobacterpylori) |
PF00449(Urease_alpha)PF01979(Amidohydro_1) | 5 | ILE B 419THR B 492GLY B 214ILE B 491VAL B 513 | None | 1.02A | 4c9lB-1e9yB:undetectable | 4c9lB-1e9yB:21.38 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 1f07 | COENZYMEF420-DEPENDENTN5,N10-METHYLENETETRAHYDROMETHANOPTERINREDUCTASE (Methanothermobacterthermautotrophicus) |
PF00296(Bac_luciferase) | 5 | LEU A 80THR A 53VAL A 20ILE A 16VAL A 17 | None | 0.95A | 4c9lB-1f07A:undetectable | 4c9lB-1f07A:22.12 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 1f51 | SPORULATIONINITIATIONPHOSPHOTRANSFERASE F (Bacillussubtilis) |
PF00072(Response_reg) | 5 | ILE E1272GLY E1262VAL E1251ILE E1276VAL E1278 | None | 0.98A | 4c9lB-1f51E:undetectable | 4c9lB-1f51E:15.09 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 1g0i | INOSITOLMONOPHOSPHATASE (Methanocaldococcusjannaschii) |
PF00459(Inositol_P) | 5 | ILE A 10GLY A 111VAL A 78ILE A 80VAL A 79 | None | 1.01A | 4c9lB-1g0iA:undetectable | 4c9lB-1g0iA:20.28 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 1jvb | NAD(H)-DEPENDENTALCOHOLDEHYDROGENASE (Sulfolobussolfataricus) |
PF00107(ADH_zinc_N)PF08240(ADH_N) | 5 | THR A 153LEU A 118GLY A 119VAL A 32ILE A 30 | None | 0.94A | 4c9lB-1jvbA:undetectable | 4c9lB-1jvbA:24.83 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 1m1l | SUPPRESSOR OF FUSED (Homo sapiens) |
PF05076(SUFU) | 6 | ILE A 91LEU A 98GLY A 33THR A 190VAL A 188VAL A 195 | None | 1.44A | 4c9lB-1m1lA:undetectable | 4c9lB-1m1lA:21.10 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 1ri3 | MRNA CAPPING ENZYME (Encephalitozooncuniculi) |
PF03291(Pox_MCEL) | 5 | LEU A 57THR A 62VAL A 68ASP A 70VAL A 136 | NoneNoneNoneSAH A 299 ( 4.9A)None | 0.99A | 4c9lB-1ri3A:undetectable | 4c9lB-1ri3A:20.92 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 1t4b | ASPARTATE-SEMIALDEHYDE DEHYDROGENASE (Escherichiacoli) |
PF01118(Semialdhyde_dh)PF02774(Semialdhyde_dhC) | 5 | ILE A 288LEU A 147GLY A 146VAL A 304VAL A 329 | None | 1.01A | 4c9lB-1t4bA:undetectable | 4c9lB-1t4bA:23.30 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 1v6c | ALKALINE SERINEPROTEASE (Pseudoalteromonassp. AS-11) |
PF00082(Peptidase_S8)PF02225(PA) | 6 | THR A 352LEU A 257LEU A 278THR A 340VAL A 231VAL A 336 | None | 1.35A | 4c9lB-1v6cA:undetectable | 4c9lB-1v6cA:19.31 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 1y1p | ALDEHYDE REDUCTASEII (Sporidiobolussalmonicolor) |
PF01370(Epimerase) | 5 | THR A 312LEU A 316LEU A 319GLY A 326ILE A 253 | None | 0.99A | 4c9lB-1y1pA:undetectable | 4c9lB-1y1pA:21.08 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 1z72 | TRANSCRIPTIONALREGULATOR, PUTATIVE (Streptococcuspneumoniae) |
PF03070(TENA_THI-4) | 5 | LEU A 18GLY A 15VAL A 140ILE A 144VAL A 143 | None | 1.00A | 4c9lB-1z72A:undetectable | 4c9lB-1z72A:20.28 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 1zgz | TORCAD OPERONTRANSCRIPTIONALREGULATORY PROTEINTORR (Escherichiacoli) |
PF00072(Response_reg) | 5 | ILE A 76LEU A 56GLY A 35THR A 32VAL A 6 | None | 1.06A | 4c9lB-1zgzA:undetectable | 4c9lB-1zgzA:14.39 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 1zk5 | F17G ADHESIN SUBUNIT (Escherichiacoli) |
PF09222(Fim-adh_lectin) | 5 | ILE A 38THR A 142LEU A 62GLY A 75THR A 77 | None | 0.95A | 4c9lB-1zk5A:undetectable | 4c9lB-1zk5A:18.23 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 1zlp | PETAL DEATH PROTEIN (Dianthuscaryophyllus) |
PF13714(PEP_mutase) | 5 | LEU A 135GLY A 111THR A 85VAL A 89VAL A 88 | None | 1.06A | 4c9lB-1zlpA:undetectable | 4c9lB-1zlpA:22.07 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 2cxi | PHENYLALANYL-TRNASYNTHETASE BETACHAIN (Pyrococcushorikoshii) |
PF03483(B3_4)PF03484(B5) | 5 | ILE A 108THR A 275LEU A 247VAL A 91VAL A 266 | None | 1.04A | 4c9lB-2cxiA:undetectable | 4c9lB-2cxiA:22.33 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 2dc1 | L-ASPARTATEDEHYDROGENASE (Archaeoglobusfulgidus) |
PF01958(DUF108)PF03447(NAD_binding_3) | 5 | ILE A 128THR A 166LEU A 115GLY A 113VAL A 163 | NoneNoneNoneNoneCIT A1585 (-4.1A) | 1.02A | 4c9lB-2dc1A:undetectable | 4c9lB-2dc1A:24.15 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 2dfu | PROBABLE2-HYDROXYHEPTA-2,4-DIENE-1,7-DIOATEISOMERASE (Thermusthermophilus) |
PF01557(FAA_hydrolase)PF10370(DUF2437) | 5 | ILE A 256GLY A 115THR A 187VAL A 189ASP A 240 | None | 1.02A | 4c9lB-2dfuA:undetectable | 4c9lB-2dfuA:22.65 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 2ego | GENERAL RECEPTOR FORPHOSPHOINOSITIDES1-ASSOCIATEDSCAFFOLD PROTEIN (Rattusnorvegicus) |
PF00595(PDZ) | 6 | THR A 185LEU A 101GLY A 147THR A 149VAL A 134ILE A 154 | None | 1.27A | 4c9lB-2egoA:undetectable | 4c9lB-2egoA:14.64 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 2hoe | N-ACETYLGLUCOSAMINEKINASE (Thermotogamaritima) |
PF00480(ROK) | 5 | ILE A 123LEU A 171LEU A 168ILE A 80VAL A 82 | None | 1.05A | 4c9lB-2hoeA:undetectable | 4c9lB-2hoeA:22.73 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 2hwy | PROTEIN SMG5 (Homo sapiens) |
PF13638(PIN_4) | 5 | LEU A 895LEU A 892GLY A 891THR A 887ASP A 860 | None | 1.03A | 4c9lB-2hwyA:undetectable | 4c9lB-2hwyA:19.52 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 2id5 | LEUCINE RICH REPEATNEURONAL 6A (Homo sapiens) |
PF07679(I-set)PF13306(LRR_5)PF13855(LRR_8) | 5 | ILE A 95LEU A 109LEU A 85GLY A 86VAL A 68 | None | 1.04A | 4c9lB-2id5A:undetectable | 4c9lB-2id5A:21.83 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 2kyl | MICROTUBULE-ASSOCIATEDSERINE/THREONINE-PROTEIN KINASE 2 (Homo sapiens) |
PF00595(PDZ) | 5 | ILE A 80THR A 91GLY A 53VAL A 40ILE A 60 | None | 1.05A | 4c9lB-2kylA:undetectable | 4c9lB-2kylA:15.27 | ||
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target. | 2m56 | CAMPHOR5-MONOOXYGENASE (Pseudomonasputida) |
PF00067(p450) | 9 | THR A 101THR A 185LEU A 244GLY A 248THR A 252VAL A 295ASP A 297ILE A 395VAL A 396 | HEM A 501 (-2.9A)NoneHEM A 501 (-4.5A)HEM A 501 (-3.9A)HEM A 501 (-3.4A)HEM A 501 (-4.6A)HEM A 501 (-2.8A)NoneNone | 0.77A | 4c9lB-2m56A:57.9 | 4c9lB-2m56A:44.44 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 2nvv | ACETYL-COAHYDROLASE/TRANSFERASE FAMILY PROTEIN (Porphyromonasgingivalis) |
PF02550(AcetylCoA_hydro)PF13336(AcetylCoA_hyd_C) | 5 | ILE A 314LEU A 330GLY A 304ILE A 291VAL A 290 | ILE A 314 ( 0.4A)LEU A 330 ( 0.6A)GLY A 304 ( 0.0A)ILE A 291 ( 0.7A)VAL A 290 ( 0.6A) | 1.02A | 4c9lB-2nvvA:undetectable | 4c9lB-2nvvA:22.98 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 2pyy | IONOTROPIC GLUTAMATERECEPTOR BACTERIALHOMOLOGUE (Nostocpunctiforme) |
PF00497(SBP_bac_3) | 5 | ILE A 105THR A 115VAL A 113ILE A 130VAL A 132 | None | 1.04A | 4c9lB-2pyyA:undetectable | 4c9lB-2pyyA:20.95 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 2qkx | BIFUNCTIONAL PROTEINGLMU (Mycobacteriumtuberculosis) |
PF00132(Hexapep)PF12804(NTP_transf_3) | 5 | ILE A 78LEU A 37GLY A 113THR A 111ILE A 53 | None | 0.97A | 4c9lB-2qkxA:undetectable | 4c9lB-2qkxA:21.72 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 2qkx | BIFUNCTIONAL PROTEINGLMU (Mycobacteriumtuberculosis) |
PF00132(Hexapep)PF12804(NTP_transf_3) | 5 | ILE A 78LEU A 37GLY A 113THR A 111VAL A 9 | None | 0.96A | 4c9lB-2qkxA:undetectable | 4c9lB-2qkxA:21.72 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 2qup | BH1478 PROTEIN (Bacillushalodurans) |
PF03885(DUF327) | 5 | ILE A 141GLY A 78VAL A 108ILE A 104VAL A 105 | None | 0.99A | 4c9lB-2qupA:undetectable | 4c9lB-2qupA:16.86 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 2qz6 | BETA-LACTAMASE (Pseudomonasfluorescens) |
PF00144(Beta-lactamase) | 5 | ILE A 224THR A 187THR A 72LEU A 184LEU A 182 | None | 0.89A | 4c9lB-2qz6A:undetectable | 4c9lB-2qz6A:24.94 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 2rq6 | ATP SYNTHASE EPSILONCHAIN (Thermosynechococcuselongatus) |
PF00401(ATP-synt_DE)PF02823(ATP-synt_DE_N) | 5 | ILE A 76THR A 42LEU A 24GLY A 32VAL A 69 | None | 1.02A | 4c9lB-2rq6A:undetectable | 4c9lB-2rq6A:15.12 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 2rq6 | ATP SYNTHASE EPSILONCHAIN (Thermosynechococcuselongatus) |
PF00401(ATP-synt_DE)PF02823(ATP-synt_DE_N) | 5 | ILE A 76THR A 42LEU A 24LEU A 31GLY A 32 | None | 0.96A | 4c9lB-2rq6A:undetectable | 4c9lB-2rq6A:15.12 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 2xkr | PUTATIVE CYTOCHROMEP450 142 (Mycobacteriumtuberculosis) |
PF00067(p450) | 5 | ILE A 65GLY A 231THR A 234VAL A 277VAL A 381 | NoneHEM A1400 (-3.2A)HEM A1400 (-3.7A)HEM A1400 (-4.5A)None | 0.88A | 4c9lB-2xkrA:44.3 | 4c9lB-2xkrA:26.51 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 2xkr | PUTATIVE CYTOCHROMEP450 142 (Mycobacteriumtuberculosis) |
PF00067(p450) | 5 | ILE A 65LEU A 226THR A 234VAL A 277VAL A 381 | NoneHEM A1400 (-4.4A)HEM A1400 (-3.7A)HEM A1400 (-4.5A)None | 0.59A | 4c9lB-2xkrA:44.3 | 4c9lB-2xkrA:26.51 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 2xkr | PUTATIVE CYTOCHROMEP450 142 (Mycobacteriumtuberculosis) |
PF00067(p450) | 5 | LEU A 226GLY A 230THR A 234VAL A 277VAL A 381 | HEM A1400 (-4.4A)PG4 A1399 ( 3.2A)HEM A1400 (-3.7A)HEM A1400 (-4.5A)None | 0.74A | 4c9lB-2xkrA:44.3 | 4c9lB-2xkrA:26.51 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 2xzd | DARPIN-3.4 (syntheticconstruct) |
PF12796(Ank_2) | 5 | ILE G 95THR G 22LEU G 67LEU G 66THR G 49 | None | 1.01A | 4c9lB-2xzdG:undetectable | 4c9lB-2xzdG:17.27 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3abi | PUTATIVEUNCHARACTERIZEDPROTEIN PH1688 (Pyrococcushorikoshii) |
PF03435(Sacchrp_dh_NADP)PF16653(Sacchrp_dh_C) | 5 | ILE A 158THR A 159LEU A 146GLY A 144THR A 224 | NoneNoneNoneSO4 A2001 (-3.0A)SO4 A2001 (-3.8A) | 0.97A | 4c9lB-3abiA:undetectable | 4c9lB-3abiA:24.68 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3asa | LL-DIAMINOPIMELATEAMINOTRANSFERASE (Chlamydiatrachomatis) |
PF00155(Aminotran_1_2) | 5 | TRP A 247THR A 207LEU A 292LEU A 289GLY A 288 | None | 0.84A | 4c9lB-3asaA:undetectable | 4c9lB-3asaA:23.69 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3dj4 | BIFUNCTIONAL PROTEINGLMU (Mycobacteriumtuberculosis) |
PF00132(Hexapep)PF12804(NTP_transf_3) | 6 | ILE A 78LEU A 37GLY A 113THR A 111VAL A 9ILE A 53 | NoneNoneUD1 A4000 (-4.1A)NoneNoneNone | 1.04A | 4c9lB-3dj4A:undetectable | 4c9lB-3dj4A:21.77 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3e05 | PRECORRIN-6YC5,15-METHYLTRANSFERASE(DECARBOXYLATING) (Geobactermetallireducens) |
no annotation | 5 | ILE A 275LEU A 244LEU A 241THR A 232ILE A 264 | None | 0.98A | 4c9lB-3e05A:undetectable | 4c9lB-3e05A:18.72 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3fi9 | MALATE DEHYDROGENASE (Porphyromonasgingivalis) |
PF00056(Ldh_1_N)PF02866(Ldh_1_C) | 5 | LEU A 106GLY A 107VAL A 145ILE A 121VAL A 120 | None | 1.04A | 4c9lB-3fi9A:undetectable | 4c9lB-3fi9A:24.55 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3i2t | EPIDERMAL GROWTHFACTOR RECEPTOR,ISOFORM A (Drosophilamelanogaster) |
PF00757(Furin-like)PF01030(Recep_L_domain)PF14843(GF_recep_IV) | 5 | ILE A 109GLY A 121VAL A 115ILE A 139VAL A 140 | None | 0.80A | 4c9lB-3i2tA:undetectable | 4c9lB-3i2tA:19.42 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3i6e | MUCONATECYCLOISOMERASE I (Ruegeriapomeroyi) |
PF02746(MR_MLE_N)PF13378(MR_MLE_C) | 5 | ILE A 138LEU A 310GLY A 306VAL A 346ILE A 352 | None | 0.92A | 4c9lB-3i6eA:undetectable | 4c9lB-3i6eA:24.13 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3kxp | ALPHA-(N-ACETYLAMINOMETHYLENE)SUCCINICACID HYDROLASE (Mesorhizobiumloti) |
PF12697(Abhydrolase_6) | 5 | THR A 203LEU A 107GLY A 40THR A 42VAL A 147 | None CL A 279 (-4.4A) CL A 279 ( 4.1A)NoneNone | 1.06A | 4c9lB-3kxpA:undetectable | 4c9lB-3kxpA:23.42 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3m8l | CAPSID PROTEIN (Felinecalicivirus) |
PF00915(Calici_coat) | 5 | ILE A 456THR A 461GLY A 536VAL A 576ILE A 437 | None | 1.06A | 4c9lB-3m8lA:undetectable | 4c9lB-3m8lA:20.70 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3mpo | PREDICTED HYDROLASEOF THE HADSUPERFAMILY (Lactobacillusbrevis) |
PF08282(Hydrolase_3) | 5 | THR A 216LEU A 200GLY A 198THR A 225ASP A 9 | None | 0.97A | 4c9lB-3mpoA:undetectable | 4c9lB-3mpoA:21.38 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3mtq | PUTATIVEPHOSPHOENOLPYRUVATE-DEPENDENT SUGARPHOSPHOTRANSFERASESYSTEM (PTS)PERMEASE (Klebsiellapneumoniae) |
PF03610(EIIA-man) | 5 | ILE A 62LEU A 95LEU A 91GLY A 90ILE A 6 | None | 1.00A | 4c9lB-3mtqA:undetectable | 4c9lB-3mtqA:15.48 | ||
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target. | 3oft | CYTOCHROME P450 (Novosphingobiumaromaticivorans) |
PF00067(p450) | 5 | LEU A 87GLY A 234THR A 238VAL A 281VAL A 384 | HEM A 417 (-4.1A)HEM A 417 (-4.0A)HEM A 417 (-3.6A)HEM A 417 ( 4.8A)None | 1.04A | 4c9lB-3oftA:50.2 | 4c9lB-3oftA:35.38 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3peh | ENDOPLASMIN HOMOLOG (Plasmodiumfalciparum) |
PF00183(HSP90)PF02518(HATPase_c) | 5 | ILE A 228GLY A 152THR A 241VAL A 206ILE A 217 | NoneIBD A1001 (-3.9A)IBD A1001 (-3.6A)NoneNone | 1.02A | 4c9lB-3pehA:undetectable | 4c9lB-3pehA:21.32 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3pqs | TRANSFERRIN-BINDINGPROTEIN (Actinobacilluspleuropneumoniae) |
PF01298(TbpB_B_D)PF17483(TbpB_C)PF17484(TbpB_A) | 5 | ILE A 389THR A 384GLY A 504VAL A 429VAL A 436 | None | 1.05A | 4c9lB-3pqsA:undetectable | 4c9lB-3pqsA:21.94 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3tvi | ASPARTOKINASE (Clostridiumacetobutylicum) |
PF00696(AA_kinase)PF01842(ACT) | 5 | ILE A 25THR A 265LEU A 13GLY A 10ILE A 35 | None | 0.94A | 4c9lB-3tviA:undetectable | 4c9lB-3tviA:19.48 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3zby | P450 HEME-THIOLATEPROTEIN (Mycolicibacteriumsmegmatis) |
PF00067(p450) | 5 | ILE A 68GLY A 234THR A 237VAL A 280VAL A 383 | NoneHEM A1402 (-3.3A)HEM A1402 (-3.7A)HEM A1402 (-4.4A)None | 0.78A | 4c9lB-3zbyA:41.7 | 4c9lB-3zbyA:28.24 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3zby | P450 HEME-THIOLATEPROTEIN (Mycolicibacteriumsmegmatis) |
PF00067(p450) | 5 | ILE A 68LEU A 229THR A 237VAL A 280VAL A 383 | NoneHEM A1402 ( 4.6A)HEM A1402 (-3.7A)HEM A1402 (-4.4A)None | 0.58A | 4c9lB-3zbyA:41.7 | 4c9lB-3zbyA:28.24 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3zby | P450 HEME-THIOLATEPROTEIN (Mycolicibacteriumsmegmatis) |
PF00067(p450) | 5 | LEU A 229GLY A 233THR A 237VAL A 280VAL A 383 | HEM A1402 ( 4.6A)EDO A1406 ( 3.4A)HEM A1402 (-3.7A)HEM A1402 (-4.4A)None | 0.73A | 4c9lB-3zbyA:41.7 | 4c9lB-3zbyA:28.24 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3zdf | GLYCERALDEHYDE-3-PHOSPHATE DEHYDROGENASE (Thermosynechococcuselongatus) |
PF00044(Gp_dh_N)PF02800(Gp_dh_C) | 5 | ILE A 162LEU A 229GLY A 219VAL A 137VAL A 134 | None | 1.06A | 4c9lB-3zdfA:undetectable | 4c9lB-3zdfA:21.76 | ||
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target. | 4c9m | CYTOCHROME P450 (Novosphingobiumaromaticivorans) |
PF00067(p450) | 12 | ILE A 88TRP A 89THR A 103THR A 187LEU A 252LEU A 255GLY A 256THR A 260VAL A 303ASP A 305ILE A 403VAL A 404 | HEM A1418 ( 4.5A)NoneGOL A1419 (-3.8A)NoneHEM A1418 (-4.0A)GOL A1419 ( 4.9A)HEM A1418 (-3.8A)HEM A1418 (-3.6A)GOL A1419 (-3.9A)HEM A1418 (-2.7A)NoneGOL A1419 (-3.5A) | 0.33A | 4c9lB-4c9mA:71.4 | 4c9lB-4c9mA:100.00 | ||
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target. | 4c9m | CYTOCHROME P450 (Novosphingobiumaromaticivorans) |
PF00067(p450) | 6 | TRP A 89LEU A 252LEU A 255GLY A 256ILE A 403VAL A 303 | NoneHEM A1418 (-4.0A)GOL A1419 ( 4.9A)HEM A1418 (-3.8A)NoneGOL A1419 (-3.9A) | 1.31A | 4c9lB-4c9mA:71.4 | 4c9lB-4c9mA:100.00 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4cw7 | PUTATIVE ADENYLATEKINASE (Pyrococcusabyssi) |
PF13238(AAA_18) | 5 | ILE A 161LEU A 86GLY A 7VAL A 130ILE A 131 | None | 1.05A | 4c9lB-4cw7A:undetectable | 4c9lB-4cw7A:18.85 | ||
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target. | 4dxy | CYTOCHROME P450 (Novosphingobiumaromaticivorans) |
PF00067(p450) | 5 | GLY A 255THR A 258VAL A 301ILE A 401VAL A 402 | HEM A 501 (-3.3A)HEM A 501 (-3.7A)PEG A 502 ( 4.5A)NoneNone | 0.86A | 4c9lB-4dxyA:55.4 | 4c9lB-4dxyA:61.24 | ||
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target. | 4dxy | CYTOCHROME P450 (Novosphingobiumaromaticivorans) |
PF00067(p450) | 8 | ILE A 86THR A 101LEU A 250GLY A 254THR A 258VAL A 301ILE A 401VAL A 402 | NoneHEM A 501 ( 4.8A)HEM A 501 (-4.3A)PEG A 502 (-3.8A)HEM A 501 (-3.7A)PEG A 502 ( 4.5A)NoneNone | 0.68A | 4c9lB-4dxyA:55.4 | 4c9lB-4dxyA:61.24 | ||
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target. | 4dxy | CYTOCHROME P450 (Novosphingobiumaromaticivorans) |
PF00067(p450) | 6 | THR A 101THR A 185LEU A 250LEU A 253GLY A 254THR A 258 | HEM A 501 ( 4.8A)NoneHEM A 501 (-4.3A)NonePEG A 502 (-3.8A)HEM A 501 (-3.7A) | 1.22A | 4c9lB-4dxyA:55.4 | 4c9lB-4dxyA:61.24 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4fek | PUTATIVE DIFLAVINFLAVOPROTEIN A 5 (Nostoc sp. PCC7120) |
no annotation | 5 | ILE A 169THR A 167LEU A 140GLY A 50ILE A 56 | None | 0.97A | 4c9lB-4fekA:undetectable | 4c9lB-4fekA:22.01 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4g41 | MTA/SAH NUCLEOSIDASE (Streptococcuspyogenes) |
PF01048(PNP_UDP_1) | 5 | ILE A 128LEU A 222VAL A 91ILE A 190VAL A 192 | ILE A 128 ( 0.6A)LEU A 222 ( 0.6A)VAL A 91 ( 0.6A)ILE A 190 ( 0.7A)VAL A 192 ( 0.6A) | 1.06A | 4c9lB-4g41A:undetectable | 4c9lB-4g41A:20.05 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4ga6 | PUTATIVE THYMIDINEPHOSPHORYLASE (Thermococcuskodakarensis) |
PF00591(Glycos_transf_3)PF02885(Glycos_trans_3N)PF07831(PYNP_C) | 5 | ILE A 122THR A 246LEU A 260LEU A 129ILE A 91 | None | 0.99A | 4c9lB-4ga6A:undetectable | 4c9lB-4ga6A:23.09 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4gu7 | PUTATIVEUNCHARACTERIZEDPROTEIN SCO7193 (Streptomycescoelicolor) |
PF04261(Dyp_perox) | 6 | ILE A 66THR A 64LEU A 39VAL A 26ILE A 28VAL A 130 | None | 1.48A | 4c9lB-4gu7A:undetectable | 4c9lB-4gu7A:25.45 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4had | PROBABLEOXIDOREDUCTASEPROTEIN (Rhizobium etli) |
PF01408(GFO_IDH_MocA) | 5 | THR A 184LEU A 222GLY A 150VAL A 247ILE A 245 | None | 0.98A | 4c9lB-4hadA:undetectable | 4c9lB-4hadA:23.13 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4hyq | PHOSPHOLIPASE A1 (Streptomycesalbidoflavus) |
PF13472(Lipase_GDSL_2) | 5 | ILE A 80THR A 58GLY A 119ILE A 175VAL A 174 | None | 0.96A | 4c9lB-4hyqA:undetectable | 4c9lB-4hyqA:20.14 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4kbx | UNCHARACTERIZEDPROTEIN YHFX (Escherichiacoli) |
PF01168(Ala_racemase_N) | 5 | THR A 125LEU A 190GLY A 189ILE A 175VAL A 176 | None | 1.05A | 4c9lB-4kbxA:undetectable | 4c9lB-4kbxA:23.48 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4mf9 | HEMIN DEGRADINGFACTOR (Pseudomonasaeruginosa) |
PF05171(HemS) | 6 | ILE A 268LEU A 113GLY A 102THR A 94VAL A 105ASP A 110 | None | 1.13A | 4c9lB-4mf9A:undetectable | 4c9lB-4mf9A:23.67 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4mfi | SN-GLYCEROL-3-PHOSPHATE ABC TRANSPORTERSUBSTRATE-BINDINGPROTEIN USPB (Mycobacteriumtuberculosis) |
PF13416(SBP_bac_8) | 5 | THR A 331LEU A 99LEU A 309GLY A 308VAL A 348 | None | 1.04A | 4c9lB-4mfiA:undetectable | 4c9lB-4mfiA:23.54 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4n91 | TRAP DICARBOXYLATETRANSPORTER, DCTPSUBUNIT (Anaerococcusprevotii) |
PF03480(DctP) | 5 | THR A 147GLY A 48VAL A 93ASP A 242VAL A 244 | NoneNoneNoneGCU A 401 ( 2.7A)None | 0.86A | 4c9lB-4n91A:undetectable | 4c9lB-4n91A:22.03 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4n9f | TRANSCRIPTIONELONGATION FACTOR BPOLYPEPTIDE 2 (Homo sapiens) |
no annotation | 5 | ILE X 30LEU X 44LEU X 77GLY X 76ILE X 34 | None | 0.97A | 4c9lB-4n9fX:undetectable | 4c9lB-4n9fX:12.65 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4o8m | TRAP DICARBOXYLATETRANSPORTER, DCTPSUBUNIT (Actinobacillussuccinogenes) |
PF03480(DctP) | 5 | THR A 233LEU A 176VAL A 302ILE A 306VAL A 305 | None | 1.00A | 4c9lB-4o8mA:undetectable | 4c9lB-4o8mA:20.92 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4p98 | EXTRACELLULARSOLUTE-BINDINGPROTEIN (Conexibacterwoesei) |
PF02608(Bmp) | 6 | ILE A 178THR A 240LEU A 229GLY A 226ASP A 147ILE A 241 | None | 0.93A | 4c9lB-4p98A:undetectable | 4c9lB-4p98A:22.55 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4q0m | L-ASPARAGINASE (Pyrococcusfuriosus) |
PF00710(Asparaginase) | 5 | ILE A 227LEU A 207GLY A 231VAL A 284ILE A 248 | None | 0.98A | 4c9lB-4q0mA:undetectable | 4c9lB-4q0mA:23.09 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4rae | HISTIDINOL-PHOSPHATEAMINOTRANSFERASE (Mycobacteriumtuberculosis) |
PF00155(Aminotran_1_2) | 5 | ILE A 365LEU A 345GLY A 343ASP A 368VAL A 370 | None | 0.86A | 4c9lB-4raeA:undetectable | 4c9lB-4raeA:23.43 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4u39 | CELL DIVISIONPROTEIN FTSZ (Bacillussubtilis) |
PF00091(Tubulin)PF12327(FtsZ_C) | 6 | ILE A 120GLY A 112THR A 109VAL A 43ILE A 17VAL A 19 | NoneNonePO4 A 401 (-4.1A)NoneNoneNone | 1.36A | 4c9lB-4u39A:undetectable | 4c9lB-4u39A:24.25 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4uc0 | PURINE NUCLEOSIDEPHOSPHORYLASE (Agrobacteriumvitis) |
PF01048(PNP_UDP_1) | 6 | ILE A 104THR A 106LEU A 27LEU A 30GLY A 28ILE A 70 | None | 1.35A | 4c9lB-4uc0A:undetectable | 4c9lB-4uc0A:22.38 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4umf | 3-DEOXY-D-MANNO-OCTULOSONATE 8-PHOSPHATEPHOSPHATASE KDSC (Moraxellacatarrhalis) |
PF00702(Hydrolase) | 5 | ILE A 125LEU A 50LEU A 47GLY A 46ILE A 21 | None | 0.89A | 4c9lB-4umfA:undetectable | 4c9lB-4umfA:17.75 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4y4n | PUTATIVE RIBOSE1,5-BISPHOSPHATEISOMERASE (Methanotorrisigneus) |
PF01946(Thi4) | 5 | ILE A 27GLY A 36VAL A 146ILE A 148VAL A 133 | None48H A 302 (-3.2A)NoneNone48H A 302 (-4.2A) | 1.05A | 4c9lB-4y4nA:undetectable | 4c9lB-4y4nA:22.60 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4yj5 | PYRUVATE KINASE PKM (Homo sapiens) |
PF00224(PK)PF02887(PK_C) | 5 | THR A 513LEU A 431VAL A 528ILE A 510VAL A 509 | None | 0.95A | 4c9lB-4yj5A:undetectable | 4c9lB-4yj5A:21.65 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4ysj | CALMODULIN-LIKEDOMAIN PROTEINKINASE (Eimeria tenella) |
PF00069(Pkinase)PF13499(EF-hand_7) | 5 | THR A 140LEU A 285LEU A 280VAL A 210ILE A 139 | None | 0.99A | 4c9lB-4ysjA:undetectable | 4c9lB-4ysjA:23.58 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 5bp7 | SAM-DEPENDENTMETHYLTRANSFERASE (Geobactersulfurreducens) |
PF13847(Methyltransf_31) | 5 | LEU A 26LEU A 29GLY A 30VAL A 41VAL A 107 | None | 0.70A | 4c9lB-5bp7A:undetectable | 4c9lB-5bp7A:21.89 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 5epe | SAM-DEPENDENTMETHYLTRANSFERASE (Thiobacillusdenitrificans) |
PF13847(Methyltransf_31) | 5 | LEU A 25LEU A 28GLY A 29VAL A 40VAL A 106 | None | 0.69A | 4c9lB-5epeA:undetectable | 4c9lB-5epeA:20.05 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 5fsa | CYP51 VARIANT1 (Candidaalbicans) |
PF00067(p450) | 5 | THR A 365LEU A 320LEU A 323ILE A 366VAL A 362 | None | 1.06A | 4c9lB-5fsaA:25.7 | 4c9lB-5fsaA:23.30 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 5gkq | ALYGC MUTANT - R241A (Paraglaciecolachathamensis) |
PF14592(Chondroitinas_B) | 5 | ILE A 504THR A 485LEU A 546VAL A 517ILE A 486 | None | 1.05A | 4c9lB-5gkqA:undetectable | 4c9lB-5gkqA:19.81 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 5hc4 | LIPOLYTIC ENZYME (unculturedbacterium) |
PF07859(Abhydrolase_3) | 5 | ILE A 281THR A 279LEU A 199GLY A 198ILE A 220 | None | 1.02A | 4c9lB-5hc4A:undetectable | 4c9lB-5hc4A:23.14 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 5huc | 3-DEOXY-D-ARABINO-HEPTULOSONATE7-PHOSPHATE (DAHP)SYNTHASE (Corynebacteriumglutamicum) |
PF01474(DAHP_synth_2) | 5 | ILE A 361THR A 343GLY A 417ILE A 344VAL A 345 | None | 1.06A | 4c9lB-5hucA:undetectable | 4c9lB-5hucA:23.00 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 5iy7 | GENERALTRANSCRIPTION FACTORIIE SUBUNIT 1 (Homo sapiens) |
PF02002(TFIIE_alpha)PF08271(TF_Zn_Ribbon) | 5 | ILE Q 38THR Q 98LEU Q 66VAL Q 21ILE Q 22 | None | 1.05A | 4c9lB-5iy7Q:undetectable | 4c9lB-5iy7Q:22.69 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 5jxm | PRIB (Streptomycessp. RM-5-8) |
PF11991(Trp_DMAT) | 5 | THR A 91LEU A 35GLY A 36VAL A 111VAL A 93 | None | 0.82A | 4c9lB-5jxmA:undetectable | 4c9lB-5jxmA:23.87 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 5k1b | WD REPEAT-CONTAININGPROTEIN 48 (Homo sapiens) |
PF00400(WD40)PF11816(DUF3337) | 6 | ILE B 375THR B 377THR B 430GLY B 427ILE B 431VAL B 20 | None | 1.34A | 4c9lB-5k1bB:undetectable | 4c9lB-5k1bB:21.33 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 5k1c | WD REPEAT-CONTAININGPROTEIN 48 (Homo sapiens) |
PF00400(WD40) | 6 | ILE B 375THR B 377THR B 430GLY B 427ILE B 431VAL B 20 | None | 1.43A | 4c9lB-5k1cB:undetectable | 4c9lB-5k1cB:22.88 | ||
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target. | 5kyo | CYP101J2 (Sphingobiumyanoikuyae) |
PF00067(p450) | 5 | GLY A 251THR A 254VAL A 297ILE A 397VAL A 398 | HEM A 501 (-3.3A)HEM A 501 (-3.5A)HEM A 501 (-4.3A)NoneNone | 0.84A | 4c9lB-5kyoA:48.5 | 4c9lB-5kyoA:39.64 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 5lq3 | CMEB (Campylobacterjejuni) |
PF00873(ACR_tran) | 5 | ILE A 413LEU A 932GLY A 931ASP A 410VAL A 481 | None | 0.82A | 4c9lB-5lq3A:undetectable | 4c9lB-5lq3A:16.97 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 5nfh | METHIONYL-TRNASYNTHETASE, PUTATIVE (Trypanosomabrucei) |
no annotation | 5 | THR A 710LEU A 606LEU A 610GLY A 611VAL A 723 | None | 1.05A | 4c9lB-5nfhA:undetectable | 4c9lB-5nfhA:21.67 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 5uja | BOVINE MULTIDRUGRESISTANCE PROTEIN 1(MRP1),MULTIDRUGRESISTANCE-ASSOCIATED PROTEIN 1 (Bos taurus) |
PF00005(ABC_tran)PF00664(ABC_membrane) | 5 | ILE A 726LEU A 750LEU A 753GLY A 756ILE A 761 | None | 0.97A | 4c9lB-5ujaA:undetectable | 4c9lB-5ujaA:16.04 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 5w5f | TAIL TUBE PROTEINGP19 (Enterobacteriaphage T4 sensulato) |
PF06841(Phage_T4_gp19) | 5 | ILE A 127LEU A 159LEU A 132GLY A 131ILE A 112 | None | 1.03A | 4c9lB-5w5fA:undetectable | 4c9lB-5w5fA:18.99 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 6f34 | AMINO ACIDTRANSPORTER (Geobacilluskaustophilus) |
no annotation | 5 | ILE A 314THR A 43LEU A 372ILE A 165VAL A 166 | NoneARG A 501 (-4.6A)NoneNoneNone | 0.80A | 4c9lB-6f34A:undetectable | 4c9lB-6f34A:undetectable | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 6fm7 | BETA-LACTAMASE (Aeromonasenteropelogenes) |
no annotation | 5 | ILE A 222THR A 185THR A 70LEU A 182LEU A 180 | None | 0.98A | 4c9lB-6fm7A:undetectable | 4c9lB-6fm7A:undetectable |