SIMILAR PATTERNS OF AMINO ACIDS FOR 4C9L_B_CAMB1419

List of similar pattern of amino acids derived from ASSAM search

Hit pattern: 3D amino acid arrangements similar to known drug binding site

Query pattern: Residues from known binding site for annotated drug that match the hit pattern


(Click link on the last column to view superposed patterns of amino acids in NGL viewer)
(Note that only 3-12 residue patterns can be used for ASSAM searches)
Filter list by:
Hit Macromolecule/
Organism
Pfam Res. Interface HETATM RMSD Dali Z-score Seq. Identity (%) View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1bhy P64K

(Neisseria
meningitidis)
PF02852
(Pyr_redox_dim)
PF07992
(Pyr_redox_2)
5 ILE A 435
GLY A 455
VAL A 424
ILE A 422
VAL A 442
None
1.02A 4c9lB-1bhyA:
0.0
4c9lB-1bhyA:
22.24
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1cf2 PROTEIN
(GLYCERALDEHYDE-3-PH
OSPHATE
DEHYDROGENASE)


(Methanothermus
fervidus)
no annotation 5 ILE P 261
GLY P 144
THR P 148
ILE P 247
VAL P 246
None
0.92A 4c9lB-1cf2P:
undetectable
4c9lB-1cf2P:
22.85
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1e9y UREASE SUBUNIT BETA

(Helicobacter
pylori)
PF00449
(Urease_alpha)
PF01979
(Amidohydro_1)
5 ILE B 419
THR B 492
GLY B 214
ILE B 491
VAL B 513
None
1.02A 4c9lB-1e9yB:
undetectable
4c9lB-1e9yB:
21.38
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1f07 COENZYME
F420-DEPENDENT
N5,N10-METHYLENETETR
AHYDROMETHANOPTERIN
REDUCTASE


(Methanothermobacter
thermautotrophicus)
PF00296
(Bac_luciferase)
5 LEU A  80
THR A  53
VAL A  20
ILE A  16
VAL A  17
None
0.95A 4c9lB-1f07A:
undetectable
4c9lB-1f07A:
22.12
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1f51 SPORULATION
INITIATION
PHOSPHOTRANSFERASE F


(Bacillus
subtilis)
PF00072
(Response_reg)
5 ILE E1272
GLY E1262
VAL E1251
ILE E1276
VAL E1278
None
0.98A 4c9lB-1f51E:
undetectable
4c9lB-1f51E:
15.09
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1g0i INOSITOL
MONOPHOSPHATASE


(Methanocaldococcus
jannaschii)
PF00459
(Inositol_P)
5 ILE A  10
GLY A 111
VAL A  78
ILE A  80
VAL A  79
None
1.01A 4c9lB-1g0iA:
undetectable
4c9lB-1g0iA:
20.28
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1jvb NAD(H)-DEPENDENT
ALCOHOL
DEHYDROGENASE


(Sulfolobus
solfataricus)
PF00107
(ADH_zinc_N)
PF08240
(ADH_N)
5 THR A 153
LEU A 118
GLY A 119
VAL A  32
ILE A  30
None
0.94A 4c9lB-1jvbA:
undetectable
4c9lB-1jvbA:
24.83
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1m1l SUPPRESSOR OF FUSED

(Homo sapiens)
PF05076
(SUFU)
6 ILE A  91
LEU A  98
GLY A  33
THR A 190
VAL A 188
VAL A 195
None
1.44A 4c9lB-1m1lA:
undetectable
4c9lB-1m1lA:
21.10
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ri3 MRNA CAPPING ENZYME

(Encephalitozoon
cuniculi)
PF03291
(Pox_MCEL)
5 LEU A  57
THR A  62
VAL A  68
ASP A  70
VAL A 136
None
None
None
SAH  A 299 ( 4.9A)
None
0.99A 4c9lB-1ri3A:
undetectable
4c9lB-1ri3A:
20.92
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1t4b ASPARTATE-SEMIALDEHY
DE DEHYDROGENASE


(Escherichia
coli)
PF01118
(Semialdhyde_dh)
PF02774
(Semialdhyde_dhC)
5 ILE A 288
LEU A 147
GLY A 146
VAL A 304
VAL A 329
None
1.01A 4c9lB-1t4bA:
undetectable
4c9lB-1t4bA:
23.30
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1v6c ALKALINE SERINE
PROTEASE


(Pseudoalteromonas
sp. AS-11)
PF00082
(Peptidase_S8)
PF02225
(PA)
6 THR A 352
LEU A 257
LEU A 278
THR A 340
VAL A 231
VAL A 336
None
1.35A 4c9lB-1v6cA:
undetectable
4c9lB-1v6cA:
19.31
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1y1p ALDEHYDE REDUCTASE
II


(Sporidiobolus
salmonicolor)
PF01370
(Epimerase)
5 THR A 312
LEU A 316
LEU A 319
GLY A 326
ILE A 253
None
0.99A 4c9lB-1y1pA:
undetectable
4c9lB-1y1pA:
21.08
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1z72 TRANSCRIPTIONAL
REGULATOR, PUTATIVE


(Streptococcus
pneumoniae)
PF03070
(TENA_THI-4)
5 LEU A  18
GLY A  15
VAL A 140
ILE A 144
VAL A 143
None
1.00A 4c9lB-1z72A:
undetectable
4c9lB-1z72A:
20.28
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1zgz TORCAD OPERON
TRANSCRIPTIONAL
REGULATORY PROTEIN
TORR


(Escherichia
coli)
PF00072
(Response_reg)
5 ILE A  76
LEU A  56
GLY A  35
THR A  32
VAL A   6
None
1.06A 4c9lB-1zgzA:
undetectable
4c9lB-1zgzA:
14.39
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1zk5 F17G ADHESIN SUBUNIT

(Escherichia
coli)
PF09222
(Fim-adh_lectin)
5 ILE A  38
THR A 142
LEU A  62
GLY A  75
THR A  77
None
0.95A 4c9lB-1zk5A:
undetectable
4c9lB-1zk5A:
18.23
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1zlp PETAL DEATH PROTEIN

(Dianthus
caryophyllus)
PF13714
(PEP_mutase)
5 LEU A 135
GLY A 111
THR A  85
VAL A  89
VAL A  88
None
1.06A 4c9lB-1zlpA:
undetectable
4c9lB-1zlpA:
22.07
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2cxi PHENYLALANYL-TRNA
SYNTHETASE BETA
CHAIN


(Pyrococcus
horikoshii)
PF03483
(B3_4)
PF03484
(B5)
5 ILE A 108
THR A 275
LEU A 247
VAL A  91
VAL A 266
None
1.04A 4c9lB-2cxiA:
undetectable
4c9lB-2cxiA:
22.33
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2dc1 L-ASPARTATE
DEHYDROGENASE


(Archaeoglobus
fulgidus)
PF01958
(DUF108)
PF03447
(NAD_binding_3)
5 ILE A 128
THR A 166
LEU A 115
GLY A 113
VAL A 163
None
None
None
None
CIT  A1585 (-4.1A)
1.02A 4c9lB-2dc1A:
undetectable
4c9lB-2dc1A:
24.15
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2dfu PROBABLE
2-HYDROXYHEPTA-2,4-D
IENE-1,7-DIOATE
ISOMERASE


(Thermus
thermophilus)
PF01557
(FAA_hydrolase)
PF10370
(DUF2437)
5 ILE A 256
GLY A 115
THR A 187
VAL A 189
ASP A 240
None
1.02A 4c9lB-2dfuA:
undetectable
4c9lB-2dfuA:
22.65
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2ego GENERAL RECEPTOR FOR
PHOSPHOINOSITIDES
1-ASSOCIATED
SCAFFOLD PROTEIN


(Rattus
norvegicus)
PF00595
(PDZ)
6 THR A 185
LEU A 101
GLY A 147
THR A 149
VAL A 134
ILE A 154
None
1.27A 4c9lB-2egoA:
undetectable
4c9lB-2egoA:
14.64
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2hoe N-ACETYLGLUCOSAMINE
KINASE


(Thermotoga
maritima)
PF00480
(ROK)
5 ILE A 123
LEU A 171
LEU A 168
ILE A  80
VAL A  82
None
1.05A 4c9lB-2hoeA:
undetectable
4c9lB-2hoeA:
22.73
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2hwy PROTEIN SMG5

(Homo sapiens)
PF13638
(PIN_4)
5 LEU A 895
LEU A 892
GLY A 891
THR A 887
ASP A 860
None
1.03A 4c9lB-2hwyA:
undetectable
4c9lB-2hwyA:
19.52
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2id5 LEUCINE RICH REPEAT
NEURONAL 6A


(Homo sapiens)
PF07679
(I-set)
PF13306
(LRR_5)
PF13855
(LRR_8)
5 ILE A  95
LEU A 109
LEU A  85
GLY A  86
VAL A  68
None
1.04A 4c9lB-2id5A:
undetectable
4c9lB-2id5A:
21.83
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2kyl MICROTUBULE-ASSOCIAT
ED
SERINE/THREONINE-PRO
TEIN KINASE 2


(Homo sapiens)
PF00595
(PDZ)
5 ILE A  80
THR A  91
GLY A  53
VAL A  40
ILE A  60
None
1.05A 4c9lB-2kylA:
undetectable
4c9lB-2kylA:
15.27
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2m56 CAMPHOR
5-MONOOXYGENASE


(Pseudomonas
putida)
PF00067
(p450)
9 THR A 101
THR A 185
LEU A 244
GLY A 248
THR A 252
VAL A 295
ASP A 297
ILE A 395
VAL A 396
HEM  A 501 (-2.9A)
None
HEM  A 501 (-4.5A)
HEM  A 501 (-3.9A)
HEM  A 501 (-3.4A)
HEM  A 501 (-4.6A)
HEM  A 501 (-2.8A)
None
None
0.77A 4c9lB-2m56A:
57.9
4c9lB-2m56A:
44.44
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2nvv ACETYL-COA
HYDROLASE/TRANSFERAS
E FAMILY PROTEIN


(Porphyromonas
gingivalis)
PF02550
(AcetylCoA_hydro)
PF13336
(AcetylCoA_hyd_C)
5 ILE A 314
LEU A 330
GLY A 304
ILE A 291
VAL A 290
ILE  A 314 ( 0.4A)
LEU  A 330 ( 0.6A)
GLY  A 304 ( 0.0A)
ILE  A 291 ( 0.7A)
VAL  A 290 ( 0.6A)
1.02A 4c9lB-2nvvA:
undetectable
4c9lB-2nvvA:
22.98
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2pyy IONOTROPIC GLUTAMATE
RECEPTOR BACTERIAL
HOMOLOGUE


(Nostoc
punctiforme)
PF00497
(SBP_bac_3)
5 ILE A 105
THR A 115
VAL A 113
ILE A 130
VAL A 132
None
1.04A 4c9lB-2pyyA:
undetectable
4c9lB-2pyyA:
20.95
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2qkx BIFUNCTIONAL PROTEIN
GLMU


(Mycobacterium
tuberculosis)
PF00132
(Hexapep)
PF12804
(NTP_transf_3)
5 ILE A  78
LEU A  37
GLY A 113
THR A 111
ILE A  53
None
0.97A 4c9lB-2qkxA:
undetectable
4c9lB-2qkxA:
21.72
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2qkx BIFUNCTIONAL PROTEIN
GLMU


(Mycobacterium
tuberculosis)
PF00132
(Hexapep)
PF12804
(NTP_transf_3)
5 ILE A  78
LEU A  37
GLY A 113
THR A 111
VAL A   9
None
0.96A 4c9lB-2qkxA:
undetectable
4c9lB-2qkxA:
21.72
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2qup BH1478 PROTEIN

(Bacillus
halodurans)
PF03885
(DUF327)
5 ILE A 141
GLY A  78
VAL A 108
ILE A 104
VAL A 105
None
0.99A 4c9lB-2qupA:
undetectable
4c9lB-2qupA:
16.86
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2qz6 BETA-LACTAMASE

(Pseudomonas
fluorescens)
PF00144
(Beta-lactamase)
5 ILE A 224
THR A 187
THR A  72
LEU A 184
LEU A 182
None
0.89A 4c9lB-2qz6A:
undetectable
4c9lB-2qz6A:
24.94
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2rq6 ATP SYNTHASE EPSILON
CHAIN


(Thermosynechococcus
elongatus)
PF00401
(ATP-synt_DE)
PF02823
(ATP-synt_DE_N)
5 ILE A  76
THR A  42
LEU A  24
GLY A  32
VAL A  69
None
1.02A 4c9lB-2rq6A:
undetectable
4c9lB-2rq6A:
15.12
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2rq6 ATP SYNTHASE EPSILON
CHAIN


(Thermosynechococcus
elongatus)
PF00401
(ATP-synt_DE)
PF02823
(ATP-synt_DE_N)
5 ILE A  76
THR A  42
LEU A  24
LEU A  31
GLY A  32
None
0.96A 4c9lB-2rq6A:
undetectable
4c9lB-2rq6A:
15.12
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2xkr PUTATIVE CYTOCHROME
P450 142


(Mycobacterium
tuberculosis)
PF00067
(p450)
5 ILE A  65
GLY A 231
THR A 234
VAL A 277
VAL A 381
None
HEM  A1400 (-3.2A)
HEM  A1400 (-3.7A)
HEM  A1400 (-4.5A)
None
0.88A 4c9lB-2xkrA:
44.3
4c9lB-2xkrA:
26.51
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2xkr PUTATIVE CYTOCHROME
P450 142


(Mycobacterium
tuberculosis)
PF00067
(p450)
5 ILE A  65
LEU A 226
THR A 234
VAL A 277
VAL A 381
None
HEM  A1400 (-4.4A)
HEM  A1400 (-3.7A)
HEM  A1400 (-4.5A)
None
0.59A 4c9lB-2xkrA:
44.3
4c9lB-2xkrA:
26.51
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2xkr PUTATIVE CYTOCHROME
P450 142


(Mycobacterium
tuberculosis)
PF00067
(p450)
5 LEU A 226
GLY A 230
THR A 234
VAL A 277
VAL A 381
HEM  A1400 (-4.4A)
PG4  A1399 ( 3.2A)
HEM  A1400 (-3.7A)
HEM  A1400 (-4.5A)
None
0.74A 4c9lB-2xkrA:
44.3
4c9lB-2xkrA:
26.51
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2xzd DARPIN-3.4

(synthetic
construct)
PF12796
(Ank_2)
5 ILE G  95
THR G  22
LEU G  67
LEU G  66
THR G  49
None
1.01A 4c9lB-2xzdG:
undetectable
4c9lB-2xzdG:
17.27
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3abi PUTATIVE
UNCHARACTERIZED
PROTEIN PH1688


(Pyrococcus
horikoshii)
PF03435
(Sacchrp_dh_NADP)
PF16653
(Sacchrp_dh_C)
5 ILE A 158
THR A 159
LEU A 146
GLY A 144
THR A 224
None
None
None
SO4  A2001 (-3.0A)
SO4  A2001 (-3.8A)
0.97A 4c9lB-3abiA:
undetectable
4c9lB-3abiA:
24.68
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3asa LL-DIAMINOPIMELATE
AMINOTRANSFERASE


(Chlamydia
trachomatis)
PF00155
(Aminotran_1_2)
5 TRP A 247
THR A 207
LEU A 292
LEU A 289
GLY A 288
None
0.84A 4c9lB-3asaA:
undetectable
4c9lB-3asaA:
23.69
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3dj4 BIFUNCTIONAL PROTEIN
GLMU


(Mycobacterium
tuberculosis)
PF00132
(Hexapep)
PF12804
(NTP_transf_3)
6 ILE A  78
LEU A  37
GLY A 113
THR A 111
VAL A   9
ILE A  53
None
None
UD1  A4000 (-4.1A)
None
None
None
1.04A 4c9lB-3dj4A:
undetectable
4c9lB-3dj4A:
21.77
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3e05 PRECORRIN-6Y
C5,15-METHYLTRANSFER
ASE
(DECARBOXYLATING)


(Geobacter
metallireducens)
no annotation 5 ILE A 275
LEU A 244
LEU A 241
THR A 232
ILE A 264
None
0.98A 4c9lB-3e05A:
undetectable
4c9lB-3e05A:
18.72
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3fi9 MALATE DEHYDROGENASE

(Porphyromonas
gingivalis)
PF00056
(Ldh_1_N)
PF02866
(Ldh_1_C)
5 LEU A 106
GLY A 107
VAL A 145
ILE A 121
VAL A 120
None
1.04A 4c9lB-3fi9A:
undetectable
4c9lB-3fi9A:
24.55
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3i2t EPIDERMAL GROWTH
FACTOR RECEPTOR,
ISOFORM A


(Drosophila
melanogaster)
PF00757
(Furin-like)
PF01030
(Recep_L_domain)
PF14843
(GF_recep_IV)
5 ILE A 109
GLY A 121
VAL A 115
ILE A 139
VAL A 140
None
0.80A 4c9lB-3i2tA:
undetectable
4c9lB-3i2tA:
19.42
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3i6e MUCONATE
CYCLOISOMERASE I


(Ruegeria
pomeroyi)
PF02746
(MR_MLE_N)
PF13378
(MR_MLE_C)
5 ILE A 138
LEU A 310
GLY A 306
VAL A 346
ILE A 352
None
0.92A 4c9lB-3i6eA:
undetectable
4c9lB-3i6eA:
24.13
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3kxp ALPHA-(N-ACETYLAMINO
METHYLENE)SUCCINIC
ACID HYDROLASE


(Mesorhizobium
loti)
PF12697
(Abhydrolase_6)
5 THR A 203
LEU A 107
GLY A  40
THR A  42
VAL A 147
None
CL  A 279 (-4.4A)
CL  A 279 ( 4.1A)
None
None
1.06A 4c9lB-3kxpA:
undetectable
4c9lB-3kxpA:
23.42
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3m8l CAPSID PROTEIN

(Feline
calicivirus)
PF00915
(Calici_coat)
5 ILE A 456
THR A 461
GLY A 536
VAL A 576
ILE A 437
None
1.06A 4c9lB-3m8lA:
undetectable
4c9lB-3m8lA:
20.70
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3mpo PREDICTED HYDROLASE
OF THE HAD
SUPERFAMILY


(Lactobacillus
brevis)
PF08282
(Hydrolase_3)
5 THR A 216
LEU A 200
GLY A 198
THR A 225
ASP A   9
None
0.97A 4c9lB-3mpoA:
undetectable
4c9lB-3mpoA:
21.38
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3mtq PUTATIVE
PHOSPHOENOLPYRUVATE-
DEPENDENT SUGAR
PHOSPHOTRANSFERASE
SYSTEM (PTS)
PERMEASE


(Klebsiella
pneumoniae)
PF03610
(EIIA-man)
5 ILE A  62
LEU A  95
LEU A  91
GLY A  90
ILE A   6
None
1.00A 4c9lB-3mtqA:
undetectable
4c9lB-3mtqA:
15.48
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3oft CYTOCHROME P450

(Novosphingobium
aromaticivorans)
PF00067
(p450)
5 LEU A  87
GLY A 234
THR A 238
VAL A 281
VAL A 384
HEM  A 417 (-4.1A)
HEM  A 417 (-4.0A)
HEM  A 417 (-3.6A)
HEM  A 417 ( 4.8A)
None
1.04A 4c9lB-3oftA:
50.2
4c9lB-3oftA:
35.38
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3peh ENDOPLASMIN HOMOLOG

(Plasmodium
falciparum)
PF00183
(HSP90)
PF02518
(HATPase_c)
5 ILE A 228
GLY A 152
THR A 241
VAL A 206
ILE A 217
None
IBD  A1001 (-3.9A)
IBD  A1001 (-3.6A)
None
None
1.02A 4c9lB-3pehA:
undetectable
4c9lB-3pehA:
21.32
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3pqs TRANSFERRIN-BINDING
PROTEIN


(Actinobacillus
pleuropneumoniae)
PF01298
(TbpB_B_D)
PF17483
(TbpB_C)
PF17484
(TbpB_A)
5 ILE A 389
THR A 384
GLY A 504
VAL A 429
VAL A 436
None
1.05A 4c9lB-3pqsA:
undetectable
4c9lB-3pqsA:
21.94
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3tvi ASPARTOKINASE

(Clostridium
acetobutylicum)
PF00696
(AA_kinase)
PF01842
(ACT)
5 ILE A  25
THR A 265
LEU A  13
GLY A  10
ILE A  35
None
0.94A 4c9lB-3tviA:
undetectable
4c9lB-3tviA:
19.48
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3zby P450 HEME-THIOLATE
PROTEIN


(Mycolicibacterium
smegmatis)
PF00067
(p450)
5 ILE A  68
GLY A 234
THR A 237
VAL A 280
VAL A 383
None
HEM  A1402 (-3.3A)
HEM  A1402 (-3.7A)
HEM  A1402 (-4.4A)
None
0.78A 4c9lB-3zbyA:
41.7
4c9lB-3zbyA:
28.24
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3zby P450 HEME-THIOLATE
PROTEIN


(Mycolicibacterium
smegmatis)
PF00067
(p450)
5 ILE A  68
LEU A 229
THR A 237
VAL A 280
VAL A 383
None
HEM  A1402 ( 4.6A)
HEM  A1402 (-3.7A)
HEM  A1402 (-4.4A)
None
0.58A 4c9lB-3zbyA:
41.7
4c9lB-3zbyA:
28.24
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3zby P450 HEME-THIOLATE
PROTEIN


(Mycolicibacterium
smegmatis)
PF00067
(p450)
5 LEU A 229
GLY A 233
THR A 237
VAL A 280
VAL A 383
HEM  A1402 ( 4.6A)
EDO  A1406 ( 3.4A)
HEM  A1402 (-3.7A)
HEM  A1402 (-4.4A)
None
0.73A 4c9lB-3zbyA:
41.7
4c9lB-3zbyA:
28.24
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3zdf GLYCERALDEHYDE-3-PHO
SPHATE DEHYDROGENASE


(Thermosynechococcus
elongatus)
PF00044
(Gp_dh_N)
PF02800
(Gp_dh_C)
5 ILE A 162
LEU A 229
GLY A 219
VAL A 137
VAL A 134
None
1.06A 4c9lB-3zdfA:
undetectable
4c9lB-3zdfA:
21.76
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4c9m CYTOCHROME P450

(Novosphingobium
aromaticivorans)
PF00067
(p450)
12 ILE A  88
TRP A  89
THR A 103
THR A 187
LEU A 252
LEU A 255
GLY A 256
THR A 260
VAL A 303
ASP A 305
ILE A 403
VAL A 404
HEM  A1418 ( 4.5A)
None
GOL  A1419 (-3.8A)
None
HEM  A1418 (-4.0A)
GOL  A1419 ( 4.9A)
HEM  A1418 (-3.8A)
HEM  A1418 (-3.6A)
GOL  A1419 (-3.9A)
HEM  A1418 (-2.7A)
None
GOL  A1419 (-3.5A)
0.33A 4c9lB-4c9mA:
71.4
4c9lB-4c9mA:
100.00
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4c9m CYTOCHROME P450

(Novosphingobium
aromaticivorans)
PF00067
(p450)
6 TRP A  89
LEU A 252
LEU A 255
GLY A 256
ILE A 403
VAL A 303
None
HEM  A1418 (-4.0A)
GOL  A1419 ( 4.9A)
HEM  A1418 (-3.8A)
None
GOL  A1419 (-3.9A)
1.31A 4c9lB-4c9mA:
71.4
4c9lB-4c9mA:
100.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4cw7 PUTATIVE ADENYLATE
KINASE


(Pyrococcus
abyssi)
PF13238
(AAA_18)
5 ILE A 161
LEU A  86
GLY A   7
VAL A 130
ILE A 131
None
1.05A 4c9lB-4cw7A:
undetectable
4c9lB-4cw7A:
18.85
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4dxy CYTOCHROME P450

(Novosphingobium
aromaticivorans)
PF00067
(p450)
5 GLY A 255
THR A 258
VAL A 301
ILE A 401
VAL A 402
HEM  A 501 (-3.3A)
HEM  A 501 (-3.7A)
PEG  A 502 ( 4.5A)
None
None
0.86A 4c9lB-4dxyA:
55.4
4c9lB-4dxyA:
61.24
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4dxy CYTOCHROME P450

(Novosphingobium
aromaticivorans)
PF00067
(p450)
8 ILE A  86
THR A 101
LEU A 250
GLY A 254
THR A 258
VAL A 301
ILE A 401
VAL A 402
None
HEM  A 501 ( 4.8A)
HEM  A 501 (-4.3A)
PEG  A 502 (-3.8A)
HEM  A 501 (-3.7A)
PEG  A 502 ( 4.5A)
None
None
0.68A 4c9lB-4dxyA:
55.4
4c9lB-4dxyA:
61.24
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4dxy CYTOCHROME P450

(Novosphingobium
aromaticivorans)
PF00067
(p450)
6 THR A 101
THR A 185
LEU A 250
LEU A 253
GLY A 254
THR A 258
HEM  A 501 ( 4.8A)
None
HEM  A 501 (-4.3A)
None
PEG  A 502 (-3.8A)
HEM  A 501 (-3.7A)
1.22A 4c9lB-4dxyA:
55.4
4c9lB-4dxyA:
61.24
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4fek PUTATIVE DIFLAVIN
FLAVOPROTEIN A 5


(Nostoc sp. PCC
7120)
no annotation 5 ILE A 169
THR A 167
LEU A 140
GLY A  50
ILE A  56
None
0.97A 4c9lB-4fekA:
undetectable
4c9lB-4fekA:
22.01
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4g41 MTA/SAH NUCLEOSIDASE

(Streptococcus
pyogenes)
PF01048
(PNP_UDP_1)
5 ILE A 128
LEU A 222
VAL A  91
ILE A 190
VAL A 192
ILE  A 128 ( 0.6A)
LEU  A 222 ( 0.6A)
VAL  A  91 ( 0.6A)
ILE  A 190 ( 0.7A)
VAL  A 192 ( 0.6A)
1.06A 4c9lB-4g41A:
undetectable
4c9lB-4g41A:
20.05
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ga6 PUTATIVE THYMIDINE
PHOSPHORYLASE


(Thermococcus
kodakarensis)
PF00591
(Glycos_transf_3)
PF02885
(Glycos_trans_3N)
PF07831
(PYNP_C)
5 ILE A 122
THR A 246
LEU A 260
LEU A 129
ILE A  91
None
0.99A 4c9lB-4ga6A:
undetectable
4c9lB-4ga6A:
23.09
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4gu7 PUTATIVE
UNCHARACTERIZED
PROTEIN SCO7193


(Streptomyces
coelicolor)
PF04261
(Dyp_perox)
6 ILE A  66
THR A  64
LEU A  39
VAL A  26
ILE A  28
VAL A 130
None
1.48A 4c9lB-4gu7A:
undetectable
4c9lB-4gu7A:
25.45
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4had PROBABLE
OXIDOREDUCTASE
PROTEIN


(Rhizobium etli)
PF01408
(GFO_IDH_MocA)
5 THR A 184
LEU A 222
GLY A 150
VAL A 247
ILE A 245
None
0.98A 4c9lB-4hadA:
undetectable
4c9lB-4hadA:
23.13
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4hyq PHOSPHOLIPASE A1

(Streptomyces
albidoflavus)
PF13472
(Lipase_GDSL_2)
5 ILE A  80
THR A  58
GLY A 119
ILE A 175
VAL A 174
None
0.96A 4c9lB-4hyqA:
undetectable
4c9lB-4hyqA:
20.14
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4kbx UNCHARACTERIZED
PROTEIN YHFX


(Escherichia
coli)
PF01168
(Ala_racemase_N)
5 THR A 125
LEU A 190
GLY A 189
ILE A 175
VAL A 176
None
1.05A 4c9lB-4kbxA:
undetectable
4c9lB-4kbxA:
23.48
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4mf9 HEMIN DEGRADING
FACTOR


(Pseudomonas
aeruginosa)
PF05171
(HemS)
6 ILE A 268
LEU A 113
GLY A 102
THR A  94
VAL A 105
ASP A 110
None
1.13A 4c9lB-4mf9A:
undetectable
4c9lB-4mf9A:
23.67
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4mfi SN-GLYCEROL-3-PHOSPH
ATE ABC TRANSPORTER
SUBSTRATE-BINDING
PROTEIN USPB


(Mycobacterium
tuberculosis)
PF13416
(SBP_bac_8)
5 THR A 331
LEU A  99
LEU A 309
GLY A 308
VAL A 348
None
1.04A 4c9lB-4mfiA:
undetectable
4c9lB-4mfiA:
23.54
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4n91 TRAP DICARBOXYLATE
TRANSPORTER, DCTP
SUBUNIT


(Anaerococcus
prevotii)
PF03480
(DctP)
5 THR A 147
GLY A  48
VAL A  93
ASP A 242
VAL A 244
None
None
None
GCU  A 401 ( 2.7A)
None
0.86A 4c9lB-4n91A:
undetectable
4c9lB-4n91A:
22.03
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4n9f TRANSCRIPTION
ELONGATION FACTOR B
POLYPEPTIDE 2


(Homo sapiens)
no annotation 5 ILE X  30
LEU X  44
LEU X  77
GLY X  76
ILE X  34
None
0.97A 4c9lB-4n9fX:
undetectable
4c9lB-4n9fX:
12.65
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4o8m TRAP DICARBOXYLATE
TRANSPORTER, DCTP
SUBUNIT


(Actinobacillus
succinogenes)
PF03480
(DctP)
5 THR A 233
LEU A 176
VAL A 302
ILE A 306
VAL A 305
None
1.00A 4c9lB-4o8mA:
undetectable
4c9lB-4o8mA:
20.92
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4p98 EXTRACELLULAR
SOLUTE-BINDING
PROTEIN


(Conexibacter
woesei)
PF02608
(Bmp)
6 ILE A 178
THR A 240
LEU A 229
GLY A 226
ASP A 147
ILE A 241
None
0.93A 4c9lB-4p98A:
undetectable
4c9lB-4p98A:
22.55
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4q0m L-ASPARAGINASE

(Pyrococcus
furiosus)
PF00710
(Asparaginase)
5 ILE A 227
LEU A 207
GLY A 231
VAL A 284
ILE A 248
None
0.98A 4c9lB-4q0mA:
undetectable
4c9lB-4q0mA:
23.09
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4rae HISTIDINOL-PHOSPHATE
AMINOTRANSFERASE


(Mycobacterium
tuberculosis)
PF00155
(Aminotran_1_2)
5 ILE A 365
LEU A 345
GLY A 343
ASP A 368
VAL A 370
None
0.86A 4c9lB-4raeA:
undetectable
4c9lB-4raeA:
23.43
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4u39 CELL DIVISION
PROTEIN FTSZ


(Bacillus
subtilis)
PF00091
(Tubulin)
PF12327
(FtsZ_C)
6 ILE A 120
GLY A 112
THR A 109
VAL A  43
ILE A  17
VAL A  19
None
None
PO4  A 401 (-4.1A)
None
None
None
1.36A 4c9lB-4u39A:
undetectable
4c9lB-4u39A:
24.25
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4uc0 PURINE NUCLEOSIDE
PHOSPHORYLASE


(Agrobacterium
vitis)
PF01048
(PNP_UDP_1)
6 ILE A 104
THR A 106
LEU A  27
LEU A  30
GLY A  28
ILE A  70
None
1.35A 4c9lB-4uc0A:
undetectable
4c9lB-4uc0A:
22.38
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4umf 3-DEOXY-D-MANNO-OCTU
LOSONATE 8-PHOSPHATE
PHOSPHATASE KDSC


(Moraxella
catarrhalis)
PF00702
(Hydrolase)
5 ILE A 125
LEU A  50
LEU A  47
GLY A  46
ILE A  21
None
0.89A 4c9lB-4umfA:
undetectable
4c9lB-4umfA:
17.75
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4y4n PUTATIVE RIBOSE
1,5-BISPHOSPHATE
ISOMERASE


(Methanotorris
igneus)
PF01946
(Thi4)
5 ILE A  27
GLY A  36
VAL A 146
ILE A 148
VAL A 133
None
48H  A 302 (-3.2A)
None
None
48H  A 302 (-4.2A)
1.05A 4c9lB-4y4nA:
undetectable
4c9lB-4y4nA:
22.60
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4yj5 PYRUVATE KINASE PKM

(Homo sapiens)
PF00224
(PK)
PF02887
(PK_C)
5 THR A 513
LEU A 431
VAL A 528
ILE A 510
VAL A 509
None
0.95A 4c9lB-4yj5A:
undetectable
4c9lB-4yj5A:
21.65
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ysj CALMODULIN-LIKE
DOMAIN PROTEIN
KINASE


(Eimeria tenella)
PF00069
(Pkinase)
PF13499
(EF-hand_7)
5 THR A 140
LEU A 285
LEU A 280
VAL A 210
ILE A 139
None
0.99A 4c9lB-4ysjA:
undetectable
4c9lB-4ysjA:
23.58
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5bp7 SAM-DEPENDENT
METHYLTRANSFERASE


(Geobacter
sulfurreducens)
PF13847
(Methyltransf_31)
5 LEU A  26
LEU A  29
GLY A  30
VAL A  41
VAL A 107
None
0.70A 4c9lB-5bp7A:
undetectable
4c9lB-5bp7A:
21.89
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5epe SAM-DEPENDENT
METHYLTRANSFERASE


(Thiobacillus
denitrificans)
PF13847
(Methyltransf_31)
5 LEU A  25
LEU A  28
GLY A  29
VAL A  40
VAL A 106
None
0.69A 4c9lB-5epeA:
undetectable
4c9lB-5epeA:
20.05
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5fsa CYP51 VARIANT1

(Candida
albicans)
PF00067
(p450)
5 THR A 365
LEU A 320
LEU A 323
ILE A 366
VAL A 362
None
1.06A 4c9lB-5fsaA:
25.7
4c9lB-5fsaA:
23.30
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5gkq ALYGC MUTANT - R241A

(Paraglaciecola
chathamensis)
PF14592
(Chondroitinas_B)
5 ILE A 504
THR A 485
LEU A 546
VAL A 517
ILE A 486
None
1.05A 4c9lB-5gkqA:
undetectable
4c9lB-5gkqA:
19.81
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5hc4 LIPOLYTIC ENZYME

(uncultured
bacterium)
PF07859
(Abhydrolase_3)
5 ILE A 281
THR A 279
LEU A 199
GLY A 198
ILE A 220
None
1.02A 4c9lB-5hc4A:
undetectable
4c9lB-5hc4A:
23.14
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5huc 3-DEOXY-D-ARABINO-HE
PTULOSONATE
7-PHOSPHATE (DAHP)
SYNTHASE


(Corynebacterium
glutamicum)
PF01474
(DAHP_synth_2)
5 ILE A 361
THR A 343
GLY A 417
ILE A 344
VAL A 345
None
1.06A 4c9lB-5hucA:
undetectable
4c9lB-5hucA:
23.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5iy7 GENERAL
TRANSCRIPTION FACTOR
IIE SUBUNIT 1


(Homo sapiens)
PF02002
(TFIIE_alpha)
PF08271
(TF_Zn_Ribbon)
5 ILE Q  38
THR Q  98
LEU Q  66
VAL Q  21
ILE Q  22
None
1.05A 4c9lB-5iy7Q:
undetectable
4c9lB-5iy7Q:
22.69
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5jxm PRIB

(Streptomyces
sp. RM-5-8)
PF11991
(Trp_DMAT)
5 THR A  91
LEU A  35
GLY A  36
VAL A 111
VAL A  93
None
0.82A 4c9lB-5jxmA:
undetectable
4c9lB-5jxmA:
23.87
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5k1b WD REPEAT-CONTAINING
PROTEIN 48


(Homo sapiens)
PF00400
(WD40)
PF11816
(DUF3337)
6 ILE B 375
THR B 377
THR B 430
GLY B 427
ILE B 431
VAL B  20
None
1.34A 4c9lB-5k1bB:
undetectable
4c9lB-5k1bB:
21.33
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5k1c WD REPEAT-CONTAINING
PROTEIN 48


(Homo sapiens)
PF00400
(WD40)
6 ILE B 375
THR B 377
THR B 430
GLY B 427
ILE B 431
VAL B  20
None
1.43A 4c9lB-5k1cB:
undetectable
4c9lB-5k1cB:
22.88
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5kyo CYP101J2

(Sphingobium
yanoikuyae)
PF00067
(p450)
5 GLY A 251
THR A 254
VAL A 297
ILE A 397
VAL A 398
HEM  A 501 (-3.3A)
HEM  A 501 (-3.5A)
HEM  A 501 (-4.3A)
None
None
0.84A 4c9lB-5kyoA:
48.5
4c9lB-5kyoA:
39.64
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5lq3 CMEB

(Campylobacter
jejuni)
PF00873
(ACR_tran)
5 ILE A 413
LEU A 932
GLY A 931
ASP A 410
VAL A 481
None
0.82A 4c9lB-5lq3A:
undetectable
4c9lB-5lq3A:
16.97
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5nfh METHIONYL-TRNA
SYNTHETASE, PUTATIVE


(Trypanosoma
brucei)
no annotation 5 THR A 710
LEU A 606
LEU A 610
GLY A 611
VAL A 723
None
1.05A 4c9lB-5nfhA:
undetectable
4c9lB-5nfhA:
21.67
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5uja BOVINE MULTIDRUG
RESISTANCE PROTEIN 1
(MRP1),MULTIDRUG
RESISTANCE-ASSOCIATE
D PROTEIN 1


(Bos taurus)
PF00005
(ABC_tran)
PF00664
(ABC_membrane)
5 ILE A 726
LEU A 750
LEU A 753
GLY A 756
ILE A 761
None
0.97A 4c9lB-5ujaA:
undetectable
4c9lB-5ujaA:
16.04
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5w5f TAIL TUBE PROTEIN
GP19


(Enterobacteria
phage T4 sensu
lato)
PF06841
(Phage_T4_gp19)
5 ILE A 127
LEU A 159
LEU A 132
GLY A 131
ILE A 112
None
1.03A 4c9lB-5w5fA:
undetectable
4c9lB-5w5fA:
18.99
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6f34 AMINO ACID
TRANSPORTER


(Geobacillus
kaustophilus)
no annotation 5 ILE A 314
THR A  43
LEU A 372
ILE A 165
VAL A 166
None
ARG  A 501 (-4.6A)
None
None
None
0.80A 4c9lB-6f34A:
undetectable
4c9lB-6f34A:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6fm7 BETA-LACTAMASE

(Aeromonas
enteropelogenes)
no annotation 5 ILE A 222
THR A 185
THR A  70
LEU A 182
LEU A 180
None
0.98A 4c9lB-6fm7A:
undetectable
4c9lB-6fm7A:
undetectable