SIMILAR PATTERNS OF AMINO ACIDS FOR 4C9K_B_CAMB424

List of similar pattern of amino acids derived from ASSAM search

Hit pattern: 3D amino acid arrangements similar to known drug binding site

Query pattern: Residues from known binding site for annotated drug that match the hit pattern


(Click link on the last column to view superposed patterns of amino acids in NGL viewer)
(Note that only 3-12 residue patterns can be used for ASSAM searches)
Filter list by:
Hit Macromolecule/
Organism
Pfam Res. Interface HETATM RMSD Dali Z-score Seq. Identity (%) View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1b1c PROTEIN
(NADPH-CYTOCHROME
P450 REDUCTASE)


(Homo sapiens)
PF00258
(Flavodoxin_1)
5 TRP A  95
THR A  99
LEU A 132
LEU A 135
GLY A 136
None
1.42A 4c9kB-1b1cA:
undetectable
4c9kB-1b1cA:
18.35
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1c2o ACETYLCHOLINESTERASE

(Electrophorus
electricus)
PF00135
(COesterase)
5 TRP A 182
GLY A 191
THR A 103
VAL A 147
VAL A 101
None
1.34A 4c9kB-1c2oA:
0.0
4c9kB-1c2oA:
23.53
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1dt2 EXFOLIATIVE TOXIN B

(Staphylococcus
aureus)
PF13365
(Trypsin_2)
5 LEU A 152
LEU A 153
GLY A 154
THR A  51
VAL A  53
None
1.45A 4c9kB-1dt2A:
undetectable
4c9kB-1dt2A:
20.85
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1gz4 NAD-DEPENDENT MALIC
ENZYME


(Homo sapiens)
PF00390
(malic)
PF03949
(Malic_M)
5 THR A 388
LEU A 292
LEU A 291
GLY A 290
VAL A 415
None
1.40A 4c9kB-1gz4A:
0.0
4c9kB-1gz4A:
23.36
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1m1l SUPPRESSOR OF FUSED

(Homo sapiens)
PF05076
(SUFU)
5 LEU A  98
GLY A  33
THR A 190
VAL A 188
VAL A 195
None
1.42A 4c9kB-1m1lA:
undetectable
4c9kB-1m1lA:
21.10
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1n0w DNA REPAIR PROTEIN
RAD51 HOMOLOG 1


(Homo sapiens)
PF08423
(Rad51)
5 THR A 123
LEU A 109
LEU A 113
GLY A 116
VAL A 264
None
None
MG  A 401 (-4.2A)
MG  A 401 (-3.8A)
None
1.49A 4c9kB-1n0wA:
undetectable
4c9kB-1n0wA:
21.41
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1n0w DNA REPAIR PROTEIN
RAD51 HOMOLOG 1


(Homo sapiens)
PF08423
(Rad51)
5 THR A 298
LEU A 109
LEU A 113
GLY A 116
VAL A 264
None
None
MG  A 401 (-4.2A)
MG  A 401 (-3.8A)
None
1.07A 4c9kB-1n0wA:
undetectable
4c9kB-1n0wA:
21.41
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1s9u PUTATIVE COMPONENT
OF ANAEROBIC
DEHYDROGENASES


(Salmonella
enterica)
PF02613
(Nitrate_red_del)
5 TRP A  46
THR A 185
LEU A  20
LEU A  17
GLY A  18
None
1.45A 4c9kB-1s9uA:
0.0
4c9kB-1s9uA:
20.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1szp DNA REPAIR PROTEIN
RAD51


(Saccharomyces
cerevisiae)
PF08423
(Rad51)
PF14520
(HHH_5)
5 THR A 356
LEU A 167
LEU A 171
GLY A 174
VAL A 322
None
1.07A 4c9kB-1szpA:
undetectable
4c9kB-1szpA:
24.31
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1tcd TRIOSEPHOSPHATE
ISOMERASE


(Trypanosoma
cruzi)
PF00121
(TIM)
5 THR A  52
LEU A  21
LEU A  22
GLY A  17
THR A  45
None
1.47A 4c9kB-1tcdA:
0.0
4c9kB-1tcdA:
19.86
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1udx THE GTP-BINDING
PROTEIN OBG


(Thermus
thermophilus)
PF01018
(GTP1_OBG)
PF01926
(MMR_HSR1)
PF09269
(DUF1967)
5 THR A 208
LEU A 162
GLY A 161
THR A 236
VAL A 323
None
1.46A 4c9kB-1udxA:
undetectable
4c9kB-1udxA:
25.26
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1umg 385AA LONG CONSERVED
HYPOTHETICAL PROTEIN


(Sulfurisphaera
tokodaii)
PF01950
(FBPase_3)
5 THR A  49
LEU A 292
LEU A 293
GLY A 294
VAL A   8
None
1.22A 4c9kB-1umgA:
undetectable
4c9kB-1umgA:
23.50
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1v6c ALKALINE SERINE
PROTEASE


(Pseudoalteromonas
sp. AS-11)
PF00082
(Peptidase_S8)
PF02225
(PA)
5 LEU A 257
LEU A 278
THR A 340
VAL A 231
VAL A 336
None
1.48A 4c9kB-1v6cA:
undetectable
4c9kB-1v6cA:
19.31
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1vko INOSITOL-3-PHOSPHATE
SYNTHASE


(Caenorhabditis
elegans)
PF01658
(Inos-1-P_synth)
PF07994
(NAD_binding_5)
5 THR A 292
LEU A 300
LEU A 297
GLY A 296
VAL A 267
None
1.41A 4c9kB-1vkoA:
undetectable
4c9kB-1vkoA:
21.68
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1xb7 STEROID HORMONE
RECEPTOR ERR1


(Homo sapiens)
PF00104
(Hormone_recep)
5 LEU A 398
LEU A 401
GLY A 402
VAL A 369
VAL A 366
None
1.10A 4c9kB-1xb7A:
undetectable
4c9kB-1xb7A:
21.66
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1xvx YFUA

(Yersinia
enterocolitica)
PF13343
(SBP_bac_6)
5 THR A 253
LEU A  60
GLY A 233
VAL A 271
VAL A  87
None
1.43A 4c9kB-1xvxA:
undetectable
4c9kB-1xvxA:
20.97
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1xvy SFUA

(Yersinia
enterocolitica)
PF13343
(SBP_bac_6)
5 THR A 250
LEU A  57
GLY A 230
VAL A 268
VAL A  84
None
1.44A 4c9kB-1xvyA:
undetectable
4c9kB-1xvyA:
22.02
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1zjr TRNA
(GUANOSINE-2'-O-)-ME
THYLTRANSFERASE


(Aquifex
aeolicus)
PF00588
(SpoU_methylase)
PF12105
(SpoU_methylas_C)
5 TYR A 117
GLY A 162
THR A  45
VAL A  51
VAL A  49
None
1.11A 4c9kB-1zjrA:
undetectable
4c9kB-1zjrA:
19.85
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1zzm PUTATIVE
DEOXYRIBONUCLEASE
YJJV


(Escherichia
coli)
PF01026
(TatD_DNase)
5 LEU A 115
LEU A 116
GLY A  99
VAL A  95
VAL A 130
None
1.47A 4c9kB-1zzmA:
undetectable
4c9kB-1zzmA:
21.36
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2b25 HYPOTHETICAL PROTEIN

(Homo sapiens)
PF08704
(GCD14)
5 LEU A  73
LEU A 119
GLY A 116
VAL A 131
VAL A 167
None
None
SAM  A 601 (-3.5A)
None
None
1.36A 4c9kB-2b25A:
undetectable
4c9kB-2b25A:
21.57
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2cri VESICLE-ASSOCIATED
MEMBRANE
PROTEIN-ASSOCIATED
PROTEIN A


(Mus musculus)
PF00635
(Motile_Sperm)
5 THR A  35
LEU A 126
LEU A  23
VAL A  61
VAL A  78
None
1.48A 4c9kB-2criA:
undetectable
4c9kB-2criA:
16.15
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2e7u GLUTAMATE-1-SEMIALDE
HYDE 2,1-AMINOMUTASE


(Thermus
thermophilus)
PF00202
(Aminotran_3)
5 TRP A 394
LEU A 417
LEU A 420
VAL A 350
VAL A 359
None
1.34A 4c9kB-2e7uA:
undetectable
4c9kB-2e7uA:
23.82
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2ego GENERAL RECEPTOR FOR
PHOSPHOINOSITIDES
1-ASSOCIATED
SCAFFOLD PROTEIN


(Rattus
norvegicus)
PF00595
(PDZ)
5 THR A 185
LEU A 101
GLY A 147
THR A 149
VAL A 134
None
1.33A 4c9kB-2egoA:
undetectable
4c9kB-2egoA:
14.64
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2m56 CAMPHOR
5-MONOOXYGENASE


(Pseudomonas
putida)
PF00067
(p450)
5 THR A 181
LEU A 244
GLY A 248
THR A 252
VAL A 396
None
HEM  A 501 (-4.5A)
HEM  A 501 (-3.9A)
HEM  A 501 (-3.4A)
None
1.31A 4c9kB-2m56A:
57.7
4c9kB-2m56A:
44.44
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2m56 CAMPHOR
5-MONOOXYGENASE


(Pseudomonas
putida)
PF00067
(p450)
7 TYR A  96
THR A 185
LEU A 244
GLY A 248
THR A 252
VAL A 295
VAL A 396
CAM  A 502 (-4.5A)
None
HEM  A 501 (-4.5A)
HEM  A 501 (-3.9A)
HEM  A 501 (-3.4A)
HEM  A 501 (-4.6A)
None
0.41A 4c9kB-2m56A:
57.7
4c9kB-2m56A:
44.44
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2oga TRANSAMINASE

(Streptomyces
venezuelae)
PF01041
(DegT_DnrJ_EryC1)
5 THR A 206
LEU A 218
GLY A  77
VAL A 162
VAL A 184
None
1.27A 4c9kB-2ogaA:
undetectable
4c9kB-2ogaA:
24.68
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2qa1 POLYKETIDE OXYGENASE
PGAE


(Streptomyces
sp. PGA64)
PF01494
(FAD_binding_3)
5 LEU A  17
LEU A 298
GLY A 299
VAL A 306
VAL A 305
None
1.21A 4c9kB-2qa1A:
undetectable
4c9kB-2qa1A:
22.87
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2rq6 ATP SYNTHASE EPSILON
CHAIN


(Thermosynechococcus
elongatus)
PF00401
(ATP-synt_DE)
PF02823
(ATP-synt_DE_N)
5 THR A  42
LEU A  24
LEU A  31
GLY A  32
VAL A  69
None
1.14A 4c9kB-2rq6A:
undetectable
4c9kB-2rq6A:
15.12
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2rq7 ATP SYNTHASE EPSILON
CHAIN


(Spinacia
oleracea;
Thermosynechococcus
elongatus)
PF00401
(ATP-synt_DE)
PF02823
(ATP-synt_DE_N)
5 LEU A  24
LEU A  31
GLY A  32
VAL A  74
VAL A  69
None
1.28A 4c9kB-2rq7A:
undetectable
4c9kB-2rq7A:
14.01
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2waa XYLAN ESTERASE,
PUTATIVE, AXE2C


(Cellvibrio
japonicus)
PF13472
(Lipase_GDSL_2)
5 TYR A 252
THR A 271
LEU A 202
GLY A 139
THR A 143
None
1.45A 4c9kB-2waaA:
undetectable
4c9kB-2waaA:
22.97
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2xkk TOPOISOMERASE IV

(Acinetobacter
baumannii)
PF00521
(DNA_topoisoIV)
PF00986
(DNA_gyraseB_C)
PF01751
(Toprim)
5 THR A1018
LEU A 572
LEU A 576
GLY A 575
VAL A 484
None
1.42A 4c9kB-2xkkA:
undetectable
4c9kB-2xkkA:
20.49
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2xkr PUTATIVE CYTOCHROME
P450 142


(Mycobacterium
tuberculosis)
PF00067
(p450)
5 LEU A 226
GLY A 230
THR A 234
VAL A 277
VAL A 381
HEM  A1400 (-4.4A)
PG4  A1399 ( 3.2A)
HEM  A1400 (-3.7A)
HEM  A1400 (-4.5A)
None
0.85A 4c9kB-2xkrA:
44.2
4c9kB-2xkrA:
26.51
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2xqh IMMUNOGLOBULIN-BINDI
NG PROTEIN EIBD


(Escherichia
coli)
PF05658
(YadA_head)
5 THR A 198
LEU A 214
GLY A 215
THR A 204
VAL A 186
None
1.45A 4c9kB-2xqhA:
undetectable
4c9kB-2xqhA:
21.43
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2z1q ACYL-COA
DEHYDROGENASE


(Thermus
thermophilus)
PF00441
(Acyl-CoA_dh_1)
PF02770
(Acyl-CoA_dh_M)
PF02771
(Acyl-CoA_dh_N)
5 THR A  39
LEU A  75
LEU A  74
VAL A  47
VAL A  43
None
1.41A 4c9kB-2z1qA:
undetectable
4c9kB-2z1qA:
22.06
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3a4t PUTATIVE
METHYLTRANSFERASE
MJ0026


(Methanocaldococcus
jannaschii)
PF01189
(Methyltr_RsmB-F)
5 THR A 136
LEU A 124
GLY A  95
THR A  99
VAL A 133
None
None
SFG  A 500 (-4.0A)
None
None
1.38A 4c9kB-3a4tA:
undetectable
4c9kB-3a4tA:
20.86
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3b3d PUTATIVE MORPHINE
DEHYDROGENASE


(Bacillus
subtilis)
PF00248
(Aldo_ket_red)
5 THR A  50
LEU A 107
LEU A 105
GLY A  61
VAL A  24
None
1.10A 4c9kB-3b3dA:
undetectable
4c9kB-3b3dA:
22.99
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3dtt NADP OXIDOREDUCTASE

(Arthrobacter
sp. FB24)
PF03807
(F420_oxidored)
5 THR A 142
LEU A 184
LEU A 181
VAL A  76
VAL A 102
None
1.01A 4c9kB-3dttA:
undetectable
4c9kB-3dttA:
21.41
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3fha ENDO-BETA-N-ACETYLGL
UCOSAMINIDASE


(Glutamicibacter
protophormiae)
PF03644
(Glyco_hydro_85)
5 TRP A 282
LEU A  55
LEU A 296
GLY A 297
VAL A 271
None
1.25A 4c9kB-3fhaA:
undetectable
4c9kB-3fhaA:
21.71
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3fn4 NAD-DEPENDENT
FORMATE
DEHYDROGENASE


(Moraxella sp.)
PF00389
(2-Hacid_dh)
PF02826
(2-Hacid_dh_C)
5 LEU A 217
GLY A 195
THR A 252
VAL A 155
VAL A 158
None
1.25A 4c9kB-3fn4A:
undetectable
4c9kB-3fn4A:
23.58
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3g1u ADENOSYLHOMOCYSTEINA
SE


(Leishmania
major)
PF00670
(AdoHcyase_NAD)
PF05221
(AdoHcyase)
5 THR A 274
LEU A 191
GLY A 226
VAL A 240
VAL A 217
None
1.34A 4c9kB-3g1uA:
undetectable
4c9kB-3g1uA:
22.37
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3i09 PERIPLASMIC
BRANCHED-CHAIN AMINO
ACID-BINDING PROTEIN


(Burkholderia
mallei)
PF13458
(Peripla_BP_6)
5 THR A 154
LEU A 224
LEU A 252
GLY A 223
VAL A 158
None
1.48A 4c9kB-3i09A:
undetectable
4c9kB-3i09A:
21.48
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3i4k MUCONATE LACTONIZING
ENZYME


(Corynebacterium
glutamicum)
PF02746
(MR_MLE_N)
PF13378
(MR_MLE_C)
5 TYR A 340
LEU A 336
GLY A 332
THR A 303
VAL A  54
TYR  A 340 ( 1.3A)
LEU  A 336 ( 0.6A)
GLY  A 332 ( 0.0A)
THR  A 303 (-0.8A)
VAL  A  54 ( 0.6A)
1.26A 4c9kB-3i4kA:
undetectable
4c9kB-3i4kA:
23.33
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3igz COFACTOR-INDEPENDENT
PHOSPHOGLYCERATE
MUTASE


(Leishmania
mexicana)
PF01676
(Metalloenzyme)
PF06415
(iPGM_N)
5 THR B 464
LEU B  82
GLY B  78
VAL B  57
VAL B 501
None
1.49A 4c9kB-3igzB:
undetectable
4c9kB-3igzB:
22.03
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3iy7 FRAGMENT FROM
NEUTRALIZING
ANTIBODY F (HEAVY
CHAIN)


(Rattus
norvegicus)
PF07686
(V-set)
5 TYR B 193
THR B 190
LEU B 167
VAL B 112
VAL B 220
None
1.36A 4c9kB-3iy7B:
undetectable
4c9kB-3iy7B:
12.23
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3lda DNA REPAIR PROTEIN
RAD51


(Saccharomyces
cerevisiae)
PF08423
(Rad51)
PF14520
(HHH_5)
5 THR A 356
LEU A 167
LEU A 171
GLY A 174
VAL A 322
None
1.08A 4c9kB-3ldaA:
undetectable
4c9kB-3ldaA:
24.52
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3mwn PHYCOERYTHRIN

(Phormidium
tenue)
PF00502
(Phycobilisome)
5 THR A1134
LEU A1159
LEU A1156
VAL A1052
VAL A1051
None
None
None
None
CYC  A3002 ( 4.5A)
1.26A 4c9kB-3mwnA:
undetectable
4c9kB-3mwnA:
13.48
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3nd1 PRECORRIN-6A
SYNTHASE/COBF
PROTEIN


(Rhodobacter
capsulatus)
PF00590
(TP_methylase)
5 TYR A 246
THR A 166
LEU A 171
GLY A 175
VAL A 164
None
1.42A 4c9kB-3nd1A:
undetectable
4c9kB-3nd1A:
21.58
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3o8o 6-PHOSPHOFRUCTOKINAS
E SUBUNIT ALPHA


(Saccharomyces
cerevisiae)
PF00365
(PFK)
5 LEU A 740
LEU A 743
THR A 782
VAL A 787
VAL A 824
None
1.19A 4c9kB-3o8oA:
undetectable
4c9kB-3o8oA:
20.48
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3one ADENOSYLHOMOCYSTEINA
SE


(Lupinus luteus)
PF00670
(AdoHcyase_NAD)
PF05221
(AdoHcyase)
5 THR A 324
LEU A 241
GLY A 276
VAL A 290
VAL A 267
None
1.35A 4c9kB-3oneA:
undetectable
4c9kB-3oneA:
21.98
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3pfe SUCCINYL-DIAMINOPIME
LATE DESUCCINYLASE


(Legionella
pneumophila)
PF01546
(Peptidase_M20)
PF07687
(M20_dimer)
5 THR A 333
LEU A 337
LEU A 335
VAL A 368
VAL A 215
None
1.45A 4c9kB-3pfeA:
undetectable
4c9kB-3pfeA:
22.24
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3pzr ASPARTATE-SEMIALDEHY
DE DEHYDROGENASE


(Vibrio cholerae)
PF01118
(Semialdhyde_dh)
PF02774
(Semialdhyde_dhC)
5 THR A 346
LEU A 143
GLY A 144
VAL A 304
VAL A 329
None
1.46A 4c9kB-3pzrA:
undetectable
4c9kB-3pzrA:
22.87
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3pzr ASPARTATE-SEMIALDEHY
DE DEHYDROGENASE


(Vibrio cholerae)
PF01118
(Semialdhyde_dh)
PF02774
(Semialdhyde_dhC)
5 THR A 346
LEU A 146
LEU A 143
GLY A 144
VAL A 304
None
1.23A 4c9kB-3pzrA:
undetectable
4c9kB-3pzrA:
22.87
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3sh5 LG3 PEPTIDE

(Homo sapiens)
PF00054
(Laminin_G_1)
5 THR A  40
LEU A  73
LEU A  68
GLY A  67
VAL A 160
None
1.09A 4c9kB-3sh5A:
undetectable
4c9kB-3sh5A:
22.19
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3uw3 ASPARTATE-SEMIALDEHY
DE DEHYDROGENASE


(Burkholderia
thailandensis)
PF01118
(Semialdhyde_dh)
PF02774
(Semialdhyde_dhC)
5 THR A 350
LEU A 146
LEU A 143
GLY A 144
VAL A 308
None
1.29A 4c9kB-3uw3A:
undetectable
4c9kB-3uw3A:
22.35
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3w9a PUTATIVE
UNCHARACTERIZED
PROTEIN


(Coprinopsis
cinerea)
no annotation 5 TYR A 179
LEU A 144
GLY A 156
VAL A 202
VAL A 203
None
1.09A 4c9kB-3w9aA:
undetectable
4c9kB-3w9aA:
18.25
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3zby P450 HEME-THIOLATE
PROTEIN


(Mycolicibacterium
smegmatis)
PF00067
(p450)
5 LEU A 229
GLY A 233
THR A 237
VAL A 280
VAL A 383
HEM  A1402 ( 4.6A)
EDO  A1406 ( 3.4A)
HEM  A1402 (-3.7A)
HEM  A1402 (-4.4A)
None
0.90A 4c9kB-3zbyA:
41.7
4c9kB-3zbyA:
28.24
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4c9m CYTOCHROME P450

(Novosphingobium
aromaticivorans)
PF00067
(p450)
5 THR A 187
GLY A 256
THR A 260
VAL A 302
VAL A 404
None
HEM  A1418 (-3.8A)
HEM  A1418 (-3.6A)
HEM  A1418 ( 4.5A)
GOL  A1419 (-3.5A)
1.46A 4c9kB-4c9mA:
71.3
4c9kB-4c9mA:
100.00
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4c9m CYTOCHROME P450

(Novosphingobium
aromaticivorans)
PF00067
(p450)
9 TRP A  89
TYR A  98
THR A 187
LEU A 252
LEU A 255
GLY A 256
THR A 260
VAL A 303
VAL A 404
None
None
None
HEM  A1418 (-4.0A)
GOL  A1419 ( 4.9A)
HEM  A1418 (-3.8A)
HEM  A1418 (-3.6A)
GOL  A1419 (-3.9A)
GOL  A1419 (-3.5A)
0.21A 4c9kB-4c9mA:
71.3
4c9kB-4c9mA:
100.00
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4dxy CYTOCHROME P450

(Novosphingobium
aromaticivorans)
PF00067
(p450)
5 LEU A 250
GLY A 254
THR A 258
VAL A 301
VAL A 402
HEM  A 501 (-4.3A)
PEG  A 502 (-3.8A)
HEM  A 501 (-3.7A)
PEG  A 502 ( 4.5A)
None
0.94A 4c9kB-4dxyA:
55.2
4c9kB-4dxyA:
61.24
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4dxy CYTOCHROME P450

(Novosphingobium
aromaticivorans)
PF00067
(p450)
5 THR A 185
LEU A 250
LEU A 253
GLY A 254
THR A 258
None
HEM  A 501 (-4.3A)
None
PEG  A 502 (-3.8A)
HEM  A 501 (-3.7A)
1.01A 4c9kB-4dxyA:
55.2
4c9kB-4dxyA:
61.24
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4gpg PROTEASE 1

(Achromobacter
lyticus)
PF00089
(Trypsin)
5 TRP A 182
THR A 189
LEU A 209
GLY A 195
THR A  37
None
1.48A 4c9kB-4gpgA:
undetectable
4c9kB-4gpgA:
21.17
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4i3g BETA-GLUCOSIDASE

(Streptomyces
venezuelae)
PF00933
(Glyco_hydro_3)
PF01915
(Glyco_hydro_3_C)
PF14310
(Fn3-like)
5 TYR A 573
THR A 590
GLY A 440
THR A 554
VAL A 546
None
SO4  A 904 (-4.5A)
None
None
None
1.29A 4c9kB-4i3gA:
undetectable
4c9kB-4i3gA:
19.40
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4k7p ANTIBODY 10C4 FAB
FRAGMENT HEAVY CHAIN


(Mus musculus)
PF07654
(C1-set)
PF07686
(V-set)
5 TYR H 122
GLY H 118
THR H 204
VAL H 197
VAL H 206
None
1.47A 4c9kB-4k7pH:
undetectable
4c9kB-4k7pH:
23.30
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ke4 HYDROXYCINNAMOYL-COA
:SHIKIMATE
HYDROXYCINNAMOYL
TRANSFERASE


(Sorghum bicolor)
PF02458
(Transferase)
5 LEU A 295
LEU A 381
GLY A 382
VAL A 417
VAL A 429
None
1.33A 4c9kB-4ke4A:
undetectable
4c9kB-4ke4A:
24.51
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4kmh SUPPRESSOR OF FUSED
HOMOLOG


(Homo sapiens)
PF05076
(SUFU)
PF12470
(SUFU_C)
5 LEU A  98
GLY A  33
THR A 190
VAL A 188
VAL A 195
None
1.42A 4c9kB-4kmhA:
undetectable
4c9kB-4kmhA:
23.29
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4l4x AMPHI

(Streptomyces
nodosus)
PF08659
(KR)
5 THR A 283
LEU A 400
LEU A 396
VAL A 306
VAL A 308
None
1.24A 4c9kB-4l4xA:
undetectable
4c9kB-4l4xA:
24.91
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4m5b COBALAMIN
BIOSYNTHESIS PROTEIN
CBIM


(Caldanaerobacter
subterraneus)
PF01891
(CbiM)
5 THR A  77
LEU A  87
LEU A  74
GLY A  70
THR A 202
HEZ  A 312 (-4.0A)
None
None
None
None
1.34A 4c9kB-4m5bA:
undetectable
4c9kB-4m5bA:
19.43
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4mfi SN-GLYCEROL-3-PHOSPH
ATE ABC TRANSPORTER
SUBSTRATE-BINDING
PROTEIN USPB


(Mycobacterium
tuberculosis)
PF13416
(SBP_bac_8)
5 THR A 331
LEU A  99
LEU A 309
GLY A 308
VAL A 348
None
1.05A 4c9kB-4mfiA:
undetectable
4c9kB-4mfiA:
23.54
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4mnr PEPTIDOGLYCAN
GLYCOSYLTRANSFERASE


(Eggerthella
lenta)
PF00905
(Transpeptidase)
5 THR A 234
LEU A 230
GLY A 199
VAL A 371
VAL A 374
None
1.33A 4c9kB-4mnrA:
undetectable
4c9kB-4mnrA:
22.91
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4nk7 SERINE/THREONINE-PRO
TEIN KINASE PLK4


(Drosophila
melanogaster)
no annotation 5 LEU A 409
GLY A 412
THR A 391
VAL A 495
VAL A 492
None
1.14A 4c9kB-4nk7A:
undetectable
4c9kB-4nk7A:
18.63
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4nsy LYSYL ENDOPEPTIDASE

(Lysobacter
enzymogenes)
PF13365
(Trypsin_2)
5 TRP A 182
THR A 189
LEU A 209
GLY A 195
THR A  37
None
2OY  A 301 (-3.6A)
2OY  A 301 ( 4.2A)
None
None
1.48A 4c9kB-4nsyA:
undetectable
4c9kB-4nsyA:
19.07
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4oh0 BETA-LACTAMASE
OXA-58


(Acinetobacter
baumannii)
PF00905
(Transpeptidase)
5 THR A  59
LEU A 274
GLY A 275
VAL A 238
VAL A 246
None
1.04A 4c9kB-4oh0A:
undetectable
4c9kB-4oh0A:
22.88
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4p0e MAF-LIKE PROTEIN
YHDE


(Escherichia
coli)
PF02545
(Maf)
5 LEU A  16
LEU A 173
GLY A 172
THR A  71
VAL A 120
None
1.29A 4c9kB-4p0eA:
undetectable
4c9kB-4p0eA:
18.57
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4s1p UNCHARACTERIZED
PROTEIN


(Slackia
heliotrinireducens)
PF13472
(Lipase_GDSL_2)
5 TYR A  80
THR A 103
LEU A  38
GLY A   7
THR A  11
None
1.10A 4c9kB-4s1pA:
undetectable
4c9kB-4s1pA:
19.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4x4j PUTATIVE OXYGENASE

(Amycolatopsis
orientalis)
PF01494
(FAD_binding_3)
5 LEU A  17
LEU A 298
GLY A 299
VAL A 306
VAL A 305
None
1.20A 4c9kB-4x4jA:
undetectable
4c9kB-4x4jA:
23.66
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4zyl RPHYB PROTEIN

(Rhodopseudomonas
palustris)
PF00072
(Response_reg)
5 TYR A 129
LEU A 120
LEU A  99
VAL A  10
VAL A  12
None
1.44A 4c9kB-4zylA:
undetectable
4c9kB-4zylA:
18.14
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5anb EUKARYOTIC
TRANSLATION
INITIATION FACTOR 6


(Dictyostelium
discoideum)
PF01912
(eIF-6)
5 LEU I  70
LEU I  71
GLY I  65
THR I 110
VAL I 135
None
1.35A 4c9kB-5anbI:
undetectable
4c9kB-5anbI:
20.71
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5b04 TRANSLATION
INITIATION FACTOR
EIF-2B SUBUNIT ALPHA


(Schizosaccharomyces
pombe)
PF01008
(IF-2B)
5 THR A 141
LEU A 153
LEU A 152
THR A 189
VAL A 166
None
1.20A 4c9kB-5b04A:
undetectable
4c9kB-5b04A:
22.10
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5bp7 SAM-DEPENDENT
METHYLTRANSFERASE


(Geobacter
sulfurreducens)
PF13847
(Methyltransf_31)
5 LEU A  26
LEU A  29
GLY A  30
VAL A  41
VAL A 107
None
0.73A 4c9kB-5bp7A:
undetectable
4c9kB-5bp7A:
21.89
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5dmn HOMOCYSTEINE
S-METHYLTRANSFERASE


(Escherichia
coli)
PF02574
(S-methyl_trans)
5 THR A 246
LEU A 239
LEU A 250
GLY A 226
VAL A 213
None
1.29A 4c9kB-5dmnA:
undetectable
4c9kB-5dmnA:
25.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ebb ACID
SPHINGOMYELINASE-LIK
E PHOSPHODIESTERASE
3A


(Homo sapiens)
PF00149
(Metallophos)
5 TYR A 168
LEU A 160
LEU A 149
GLY A 150
VAL A 125
None
1.39A 4c9kB-5ebbA:
undetectable
4c9kB-5ebbA:
21.61
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5epe SAM-DEPENDENT
METHYLTRANSFERASE


(Thiobacillus
denitrificans)
PF13847
(Methyltransf_31)
5 LEU A  25
LEU A  28
GLY A  29
VAL A  40
VAL A 106
None
0.71A 4c9kB-5epeA:
undetectable
4c9kB-5epeA:
20.05
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5exk LIPOYL SYNTHASE

(Mycobacterium
tuberculosis)
PF04055
(Radical_SAM)
PF16881
(LIAS_N)
5 THR A 139
LEU A  98
LEU A 135
GLY A  77
VAL A 106
None
1.36A 4c9kB-5exkA:
undetectable
4c9kB-5exkA:
24.72
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ffp IMMUNITY 23 FAMILY
PROTEIN


(Burkholderia
dolosa)
PF15593
(Imm42)
5 LEU A 105
LEU A  29
GLY A  30
VAL A 148
VAL A 151
None
1.31A 4c9kB-5ffpA:
undetectable
4c9kB-5ffpA:
14.92
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5frs SISTER CHROMATID
COHESION PROTEIN
PDS5


(Saccharomyces
cerevisiae)
PF12717
(Cnd1)
5 TYR A 157
LEU A 223
LEU A 175
GLY A 176
VAL A 185
None
1.42A 4c9kB-5frsA:
undetectable
4c9kB-5frsA:
18.99
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5g5g PUTATIVE XANTHINE
DEHYDROGENASE YAGS
FAD-BINDING SUBUNIT


(Escherichia
coli)
PF01315
(Ald_Xan_dh_C)
PF02738
(Ald_Xan_dh_C2)
5 THR C 710
LEU C 725
LEU C 728
GLY C 600
VAL C 706
None
1.46A 4c9kB-5g5gC:
undetectable
4c9kB-5g5gC:
22.11
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5gja 1-AMINOCYCLOPROPANE-
1-CARBOXYLATE
OXIDASE 2


(Arabidopsis
thaliana)
PF03171
(2OG-FeII_Oxy)
PF14226
(DIOX_N)
5 TRP A  89
LEU A  72
GLY A  76
VAL A  84
VAL A  87
None
1.25A 4c9kB-5gjaA:
undetectable
4c9kB-5gjaA:
21.97
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5gje LOW-DENSITY
LIPOPROTEIN
RECEPTOR-RELATED
PROTEIN 6


(Homo sapiens)
PF00058
(Ldl_recept_b)
PF14670
(FXa_inhibition)
5 TRP A 220
LEU A 239
GLY A 238
VAL A 200
VAL A 201
None
1.37A 4c9kB-5gjeA:
undetectable
4c9kB-5gjeA:
23.66
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5hqj PERIPLASMIC BINDING
PROTEIN/LACI
TRANSCRIPTIONAL
REGULATOR


(Paraburkholderia
graminis)
PF13407
(Peripla_BP_4)
5 THR A 206
LEU A 213
GLY A 215
VAL A 227
VAL A 203
None
1.41A 4c9kB-5hqjA:
undetectable
4c9kB-5hqjA:
24.04
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5jxm PRIB

(Streptomyces
sp. RM-5-8)
PF11991
(Trp_DMAT)
5 THR A  91
LEU A  35
GLY A  36
VAL A 111
VAL A  93
None
0.78A 4c9kB-5jxmA:
undetectable
4c9kB-5jxmA:
23.87
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5kar ACID
SPHINGOMYELINASE-LIK
E PHOSPHODIESTERASE
3B


(Mus musculus)
PF00149
(Metallophos)
5 TYR A 151
LEU A 132
GLY A 133
VAL A 108
VAL A 112
None
1.35A 4c9kB-5karA:
undetectable
4c9kB-5karA:
23.12
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5kju SHIKIMATE
O-HYDROXYCINNAMOYLTR
ANSFERASE


(Arabidopsis
thaliana)
PF02458
(Transferase)
5 LEU A 279
LEU A 366
GLY A 367
VAL A 402
VAL A 414
None
1.21A 4c9kB-5kjuA:
undetectable
4c9kB-5kjuA:
22.27
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5nfh METHIONYL-TRNA
SYNTHETASE, PUTATIVE


(Trypanosoma
brucei)
no annotation 5 THR A 710
LEU A 606
LEU A 610
GLY A 611
VAL A 723
None
1.04A 4c9kB-5nfhA:
undetectable
4c9kB-5nfhA:
21.67
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5u09 CANNABINOID RECEPTOR
1,GLGA GLYCOGEN
SYNTHASE


(Homo sapiens;
Pyrococcus
abyssi)
PF00001
(7tm_1)
PF00534
(Glycos_transf_1)
5 TRP A 279
THR A 283
LEU A 359
LEU A 360
GLY A 357
None
None
7DY  A1210 ( 4.9A)
None
None
1.37A 4c9kB-5u09A:
undetectable
4c9kB-5u09A:
22.57
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5umx GLYOXALASE/BLEOMYCIN
RESISANCE
PROTEIN/DIOXYGENASE


(Streptomyces
sp. CB03234)
no annotation 5 LEU A  73
LEU A 116
GLY A 115
VAL A  90
VAL A  92
None
1.34A 4c9kB-5umxA:
undetectable
4c9kB-5umxA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5vj1 MDCA

(Pseudomonas
aeruginosa)
PF16957
(Mal_decarbox_Al)
5 THR A 445
LEU A 126
LEU A 121
GLY A 118
VAL A 441
None
1.36A 4c9kB-5vj1A:
undetectable
4c9kB-5vj1A:
23.29
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5wwl CENTROMERE PROTEIN
MIS12
KINETOCHORE PROTEIN
NNF1


(Schizosaccharomyces
pombe;
Schizosaccharomyces
pombe)
no annotation
no annotation
5 THR N  19
LEU N  12
LEU N  16
THR M  21
VAL M  64
None
1.49A 4c9kB-5wwlN:
undetectable
4c9kB-5wwlN:
17.54
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5xra CANNABINOID RECEPTOR
1,FLAVODOXIN,CANNABI
NOID RECEPTOR 1


(Desulfovibrio
vulgaris;
Homo sapiens)
PF00001
(7tm_1)
PF00258
(Flavodoxin_1)
5 TRP A 279
LEU A 359
LEU A 360
GLY A 357
VAL A 204
8D3  A 602 ( 3.5A)
8D3  A 602 ( 4.5A)
None
None
None
1.29A 4c9kB-5xraA:
undetectable
4c9kB-5xraA:
22.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6bog RNA
POLYMERASE-ASSOCIATE
D PROTEIN RAPA


(Escherichia
coli)
no annotation 5 LEU A  81
LEU A  80
GLY A  79
THR A   4
VAL A  22
None
1.28A 4c9kB-6bogA:
undetectable
4c9kB-6bogA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6bog RNA
POLYMERASE-ASSOCIATE
D PROTEIN RAPA


(Escherichia
coli)
no annotation 5 LEU A  81
LEU A  80
GLY A  79
THR A   4
VAL A  22
None
1.34A 4c9kB-6bogA:
undetectable
4c9kB-6bogA:
undetectable