SIMILAR PATTERNS OF AMINO ACIDS FOR 4C9K_A_CAMA424_0

List of similar pattern of amino acids derived from ASSAM search

Hit pattern: 3D amino acid arrangements similar to known drug binding site

Query pattern: Residues from known binding site for annotated drug that match the hit pattern


(Click link on the last column to view superposed patterns of amino acids in NGL viewer)
(Note that only 3-12 residue patterns can be used for ASSAM searches)
Filter list by:
Hit Macromolecule/
Organism
Pfam Res. Interface HETATM RMSD Dali Z-score Seq. Identity (%) View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1d2k CHITINASE 1

(Coccidioides
immitis)
PF00704
(Glyco_hydro_18)
5 TRP A 377
THR A  65
LEU A 404
LEU A 398
VAL A 287
None
1.34A 4c9kA-1d2kA:
0.0
4c9kA-1d2kA:
20.39
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1dpp DIPEPTIDE BINDING
PROTEIN


(Escherichia
coli)
PF00496
(SBP_bac_5)
5 THR A  44
THR A 313
LEU A 496
LEU A 262
GLY A 407
None
1.45A 4c9kA-1dppA:
0.0
4c9kA-1dppA:
21.57
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1hxi PEROXISOME TARGETING
SIGNAL 1 RECEPTOR
PEX5


(Trypanosoma
brucei)
no annotation 5 THR A 392
LEU A 360
LEU A 357
GLY A 356
VAL A 375
None
1.45A 4c9kA-1hxiA:
undetectable
4c9kA-1hxiA:
14.96
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ibq ASPERGILLOPEPSIN

(Aspergillus
phoenicis)
PF00026
(Asp)
5 TYR A 164
THR A 215
LEU A 121
GLY A 122
THR A 138
None
1.12A 4c9kA-1ibqA:
undetectable
4c9kA-1ibqA:
21.82
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ize ASPARTIC PROTEINASE

(Aspergillus
oryzae)
PF00026
(Asp)
5 TYR A 165
THR A 215
LEU A 122
GLY A 123
THR A 139
None
1.13A 4c9kA-1izeA:
undetectable
4c9kA-1izeA:
21.15
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1n0w DNA REPAIR PROTEIN
RAD51 HOMOLOG 1


(Homo sapiens)
PF08423
(Rad51)
5 THR A 298
LEU A 109
LEU A 113
GLY A 116
VAL A 264
None
None
MG  A 401 (-4.2A)
MG  A 401 (-3.8A)
None
1.08A 4c9kA-1n0wA:
0.0
4c9kA-1n0wA:
21.41
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1nrw HYPOTHETICAL
PROTEIN, HALOACID
DEHALOGENASE-LIKE
HYDROLASE


(Bacillus
subtilis)
PF08282
(Hydrolase_3)
5 THR A 269
LEU A 245
GLY A 236
THR A  11
VAL A 277
None
1.49A 4c9kA-1nrwA:
0.0
4c9kA-1nrwA:
22.14
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1s9u PUTATIVE COMPONENT
OF ANAEROBIC
DEHYDROGENASES


(Salmonella
enterica)
PF02613
(Nitrate_red_del)
5 TRP A  46
THR A 185
LEU A  20
LEU A  17
GLY A  18
None
1.47A 4c9kA-1s9uA:
0.0
4c9kA-1s9uA:
20.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1szp DNA REPAIR PROTEIN
RAD51


(Saccharomyces
cerevisiae)
PF08423
(Rad51)
PF14520
(HHH_5)
5 THR A 356
LEU A 167
LEU A 171
GLY A 174
VAL A 322
None
1.07A 4c9kA-1szpA:
undetectable
4c9kA-1szpA:
24.31
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1udx THE GTP-BINDING
PROTEIN OBG


(Thermus
thermophilus)
PF01018
(GTP1_OBG)
PF01926
(MMR_HSR1)
PF09269
(DUF1967)
5 THR A 208
LEU A 162
GLY A 161
THR A 236
VAL A 323
None
1.46A 4c9kA-1udxA:
0.0
4c9kA-1udxA:
25.26
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1umg 385AA LONG CONSERVED
HYPOTHETICAL PROTEIN


(Sulfurisphaera
tokodaii)
PF01950
(FBPase_3)
5 THR A  49
LEU A 292
LEU A 293
GLY A 294
VAL A   8
None
1.25A 4c9kA-1umgA:
undetectable
4c9kA-1umgA:
23.50
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1v6c ALKALINE SERINE
PROTEASE


(Pseudoalteromonas
sp. AS-11)
PF00082
(Peptidase_S8)
PF02225
(PA)
5 THR A 352
LEU A 257
LEU A 278
THR A 340
VAL A 231
None
1.44A 4c9kA-1v6cA:
undetectable
4c9kA-1v6cA:
19.31
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1vko INOSITOL-3-PHOSPHATE
SYNTHASE


(Caenorhabditis
elegans)
PF01658
(Inos-1-P_synth)
PF07994
(NAD_binding_5)
5 THR A 292
LEU A 300
LEU A 297
GLY A 296
VAL A 267
None
1.43A 4c9kA-1vkoA:
undetectable
4c9kA-1vkoA:
21.68
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1y1p ALDEHYDE REDUCTASE
II


(Sporidiobolus
salmonicolor)
PF01370
(Epimerase)
5 THR A 312
LEU A 316
LEU A 319
GLY A 326
VAL A 248
None
1.27A 4c9kA-1y1pA:
undetectable
4c9kA-1y1pA:
21.08
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1yqd SINAPYL ALCOHOL
DEHYDROGENASE


(Populus
tremuloides)
PF00107
(ADH_zinc_N)
PF08240
(ADH_N)
5 THR A 211
LEU A 268
LEU A 248
GLY A 250
VAL A 190
None
1.37A 4c9kA-1yqdA:
undetectable
4c9kA-1yqdA:
22.10
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2ego GENERAL RECEPTOR FOR
PHOSPHOINOSITIDES
1-ASSOCIATED
SCAFFOLD PROTEIN


(Rattus
norvegicus)
PF00595
(PDZ)
5 THR A 185
LEU A 101
GLY A 147
THR A 149
VAL A 134
None
1.33A 4c9kA-2egoA:
undetectable
4c9kA-2egoA:
14.64
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2jek RV1873

(Mycobacterium
tuberculosis)
PF08837
(DUF1810)
5 THR A 116
THR A  82
LEU A  69
LEU A  78
GLY A  75
None
1.41A 4c9kA-2jekA:
undetectable
4c9kA-2jekA:
18.62
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2m56 CAMPHOR
5-MONOOXYGENASE


(Pseudomonas
putida)
PF00067
(p450)
5 THR A 181
LEU A 244
GLY A 248
THR A 252
VAL A 396
None
HEM  A 501 (-4.5A)
HEM  A 501 (-3.9A)
HEM  A 501 (-3.4A)
None
1.30A 4c9kA-2m56A:
57.9
4c9kA-2m56A:
44.44
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2m56 CAMPHOR
5-MONOOXYGENASE


(Pseudomonas
putida)
PF00067
(p450)
5 TYR A  96
LEU A 244
GLY A 248
THR A 252
VAL A 396
CAM  A 502 (-4.5A)
HEM  A 501 (-4.5A)
HEM  A 501 (-3.9A)
HEM  A 501 (-3.4A)
None
1.28A 4c9kA-2m56A:
57.9
4c9kA-2m56A:
44.44
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2m56 CAMPHOR
5-MONOOXYGENASE


(Pseudomonas
putida)
PF00067
(p450)
7 TYR A  96
THR A 101
THR A 185
LEU A 244
GLY A 248
THR A 252
VAL A 295
CAM  A 502 (-4.5A)
HEM  A 501 (-2.9A)
None
HEM  A 501 (-4.5A)
HEM  A 501 (-3.9A)
HEM  A 501 (-3.4A)
HEM  A 501 (-4.6A)
0.51A 4c9kA-2m56A:
57.9
4c9kA-2m56A:
44.44
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2ql8 PUTATIVE REDOX
PROTEIN


(Lactobacillus
paracasei)
PF02566
(OsmC)
5 THR A 136
LEU A  63
GLY A  76
THR A  75
VAL A 104
None
1.42A 4c9kA-2ql8A:
undetectable
4c9kA-2ql8A:
16.39
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2rq6 ATP SYNTHASE EPSILON
CHAIN


(Thermosynechococcus
elongatus)
PF00401
(ATP-synt_DE)
PF02823
(ATP-synt_DE_N)
5 THR A  42
LEU A  24
LEU A  31
GLY A  32
VAL A  69
None
1.14A 4c9kA-2rq6A:
undetectable
4c9kA-2rq6A:
15.12
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2v9q ROUNDABOUT HOMOLOG 1

(Homo sapiens)
PF07679
(I-set)
PF13927
(Ig_3)
5 THR A 110
THR A  86
LEU A 121
LEU A 122
GLY A 125
None
1.38A 4c9kA-2v9qA:
undetectable
4c9kA-2v9qA:
19.50
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2v9t ROUNDABOUT HOMOLOG 1

(Homo sapiens)
PF13927
(Ig_3)
5 THR A 110
THR A  86
LEU A 121
LEU A 122
GLY A 125
None
1.48A 4c9kA-2v9tA:
undetectable
4c9kA-2v9tA:
14.50
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2waa XYLAN ESTERASE,
PUTATIVE, AXE2C


(Cellvibrio
japonicus)
PF13472
(Lipase_GDSL_2)
5 TYR A 252
THR A 271
LEU A 202
GLY A 139
THR A 143
None
1.44A 4c9kA-2waaA:
undetectable
4c9kA-2waaA:
22.97
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2wed PENICILLOPEPSIN

(Penicillium
janthinellum)
PF00026
(Asp)
5 TYR A 165
THR A 214
LEU A 122
GLY A 123
THR A 139
None
1.22A 4c9kA-2wedA:
undetectable
4c9kA-2wedA:
20.23
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2wkn FORMAMIDASE

(Delftia
acidovorans)
PF03069
(FmdA_AmdA)
5 THR A 214
LEU A 154
GLY A 249
THR A  44
VAL A  20
None
1.26A 4c9kA-2wknA:
undetectable
4c9kA-2wknA:
22.72
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3aoe GLUTAMATE
DEHYDROGENASE


(Thermus
thermophilus)
PF00208
(ELFV_dehydrog)
PF02812
(ELFV_dehydrog_N)
5 THR A 205
LEU A 383
LEU A 379
GLY A 352
VAL A 230
None
1.42A 4c9kA-3aoeA:
undetectable
4c9kA-3aoeA:
24.43
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3asa LL-DIAMINOPIMELATE
AMINOTRANSFERASE


(Chlamydia
trachomatis)
PF00155
(Aminotran_1_2)
5 TRP A 247
THR A 207
LEU A 292
LEU A 289
GLY A 288
None
0.79A 4c9kA-3asaA:
undetectable
4c9kA-3asaA:
23.69
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3bn3 INTERCELLULAR
ADHESION MOLECULE 5


(Homo sapiens)
PF03921
(ICAM_N)
5 THR B  45
THR B  38
LEU B  52
LEU B  36
GLY B  35
None
1.32A 4c9kA-3bn3B:
undetectable
4c9kA-3bn3B:
19.50
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3cih PUTATIVE
ALPHA-RHAMNOSIDASE


(Bacteroides
thetaiotaomicron)
PF17389
(Bac_rhamnosid6H)
PF17390
(Bac_rhamnosid_C)
5 TYR A 522
THR A 520
THR A 555
LEU A 447
GLY A 445
None
1.49A 4c9kA-3cihA:
undetectable
4c9kA-3cihA:
19.87
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3cin MYO-INOSITOL-1-PHOSP
HATE
SYNTHASE-RELATED
PROTEIN


(Thermotoga
maritima)
PF01658
(Inos-1-P_synth)
PF07994
(NAD_binding_5)
5 THR A 211
THR A 130
LEU A 324
GLY A 321
THR A  15
NAD  A 400 (-3.5A)
None
None
None
None
1.10A 4c9kA-3cinA:
undetectable
4c9kA-3cinA:
23.01
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3dla GLUTAMINE-DEPENDENT
NAD(+) SYNTHETASE


(Mycobacterium
tuberculosis)
PF00795
(CN_hydrolase)
PF02540
(NAD_synthase)
5 TYR A   7
THR A 276
LEU A 310
LEU A 166
VAL A 196
None
1.26A 4c9kA-3dlaA:
undetectable
4c9kA-3dlaA:
21.27
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3fha ENDO-BETA-N-ACETYLGL
UCOSAMINIDASE


(Glutamicibacter
protophormiae)
PF03644
(Glyco_hydro_85)
5 TRP A 282
LEU A  55
LEU A 296
GLY A 297
VAL A 271
None
1.25A 4c9kA-3fhaA:
undetectable
4c9kA-3fhaA:
21.71
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3i4k MUCONATE LACTONIZING
ENZYME


(Corynebacterium
glutamicum)
PF02746
(MR_MLE_N)
PF13378
(MR_MLE_C)
5 TYR A 340
LEU A 336
GLY A 332
THR A 303
VAL A  54
TYR  A 340 ( 1.3A)
LEU  A 336 ( 0.6A)
GLY  A 332 ( 0.0A)
THR  A 303 (-0.8A)
VAL  A  54 ( 0.6A)
1.28A 4c9kA-3i4kA:
undetectable
4c9kA-3i4kA:
23.33
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3jb9 PRE-MRNA-SPLICING
FACTOR CWF11


(Schizosaccharomyces
pombe)
PF13087
(AAA_12)
PF16399
(Aquarius_N)
5 THR X 774
LEU X 765
LEU X 761
GLY X 738
THR X 744
None
1.28A 4c9kA-3jb9X:
undetectable
4c9kA-3jb9X:
14.76
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3lda DNA REPAIR PROTEIN
RAD51


(Saccharomyces
cerevisiae)
PF08423
(Rad51)
PF14520
(HHH_5)
5 THR A 356
LEU A 167
LEU A 171
GLY A 174
VAL A 322
None
1.08A 4c9kA-3ldaA:
undetectable
4c9kA-3ldaA:
24.52
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ogz UDP-SUGAR
PYROPHOSPHORYLASE


(Leishmania
major)
PF01704
(UDPGP)
5 THR A 115
LEU A 284
GLY A 108
THR A 109
VAL A 158
None
1.48A 4c9kA-3ogzA:
undetectable
4c9kA-3ogzA:
22.14
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ogz UDP-SUGAR
PYROPHOSPHORYLASE


(Leishmania
major)
PF01704
(UDPGP)
5 TRP A 154
THR A 115
THR A 277
LEU A 284
THR A 361
None
1.45A 4c9kA-3ogzA:
undetectable
4c9kA-3ogzA:
22.14
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3p11 RECEPTOR
TYROSINE-PROTEIN
KINASE ERBB-3


(Homo sapiens)
PF00757
(Furin-like)
PF01030
(Recep_L_domain)
PF14843
(GF_recep_IV)
5 THR A  13
THR A  49
LEU A  33
LEU A  30
VAL A  19
None
1.41A 4c9kA-3p11A:
undetectable
4c9kA-3p11A:
19.93
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3sh5 LG3 PEPTIDE

(Homo sapiens)
PF00054
(Laminin_G_1)
5 THR A  40
LEU A  73
LEU A  68
GLY A  67
VAL A 160
None
1.15A 4c9kA-3sh5A:
undetectable
4c9kA-3sh5A:
22.19
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3t4c 2-DEHYDRO-3-DEOXYPHO
SPHOOCTONATE
ALDOLASE 1


(Burkholderia
ambifaria)
PF00793
(DAHP_synth_1)
5 TYR A  49
THR A  29
THR A  89
LEU A  76
GLY A  72
None
0.96A 4c9kA-3t4cA:
undetectable
4c9kA-3t4cA:
22.51
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3uw3 ASPARTATE-SEMIALDEHY
DE DEHYDROGENASE


(Burkholderia
thailandensis)
PF01118
(Semialdhyde_dh)
PF02774
(Semialdhyde_dhC)
5 THR A 350
LEU A 146
LEU A 143
GLY A 144
VAL A 308
None
1.32A 4c9kA-3uw3A:
undetectable
4c9kA-3uw3A:
22.35
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ad9 BETA-LACTAMASE-LIKE
PROTEIN 2


(Homo sapiens)
PF00753
(Lactamase_B)
5 TYR A 180
THR A 172
THR A 142
GLY A 163
THR A  76
None
1.07A 4c9kA-4ad9A:
undetectable
4c9kA-4ad9A:
22.27
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4amg SNOGD

(Streptomyces
nogalater)
PF06722
(DUF1205)
5 THR A 264
LEU A 291
LEU A 292
GLY A 289
THR A 309
None
1.33A 4c9kA-4amgA:
undetectable
4c9kA-4amgA:
23.74
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4c9m CYTOCHROME P450

(Novosphingobium
aromaticivorans)
PF00067
(p450)
7 TRP A  89
TYR A  98
THR A 103
LEU A 252
GLY A 256
THR A 260
VAL A 404
None
None
GOL  A1419 (-3.8A)
HEM  A1418 (-4.0A)
HEM  A1418 (-3.8A)
HEM  A1418 (-3.6A)
GOL  A1419 (-3.5A)
1.34A 4c9kA-4c9mA:
72.4
4c9kA-4c9mA:
100.00
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4c9m CYTOCHROME P450

(Novosphingobium
aromaticivorans)
PF00067
(p450)
9 TRP A  89
TYR A  98
THR A 103
THR A 187
LEU A 252
LEU A 255
GLY A 256
THR A 260
VAL A 303
None
None
GOL  A1419 (-3.8A)
None
HEM  A1418 (-4.0A)
GOL  A1419 ( 4.9A)
HEM  A1418 (-3.8A)
HEM  A1418 (-3.6A)
GOL  A1419 (-3.9A)
0.15A 4c9kA-4c9mA:
72.4
4c9kA-4c9mA:
100.00
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4dxy CYTOCHROME P450

(Novosphingobium
aromaticivorans)
PF00067
(p450)
5 THR A 101
LEU A 250
GLY A 254
THR A 258
VAL A 301
HEM  A 501 ( 4.8A)
HEM  A 501 (-4.3A)
PEG  A 502 (-3.8A)
HEM  A 501 (-3.7A)
PEG  A 502 ( 4.5A)
0.93A 4c9kA-4dxyA:
55.5
4c9kA-4dxyA:
61.24
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4dxy CYTOCHROME P450

(Novosphingobium
aromaticivorans)
PF00067
(p450)
5 THR A 101
THR A 185
LEU A 250
GLY A 254
THR A 258
HEM  A 501 ( 4.8A)
None
HEM  A 501 (-4.3A)
PEG  A 502 (-3.8A)
HEM  A 501 (-3.7A)
1.12A 4c9kA-4dxyA:
55.5
4c9kA-4dxyA:
61.24
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4dxy CYTOCHROME P450

(Novosphingobium
aromaticivorans)
PF00067
(p450)
5 THR A 101
THR A 185
LEU A 250
LEU A 253
GLY A 254
HEM  A 501 ( 4.8A)
None
HEM  A 501 (-4.3A)
None
PEG  A 502 (-3.8A)
1.17A 4c9kA-4dxyA:
55.5
4c9kA-4dxyA:
61.24
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4gpg PROTEASE 1

(Achromobacter
lyticus)
PF00089
(Trypsin)
5 TRP A 182
THR A 189
LEU A 209
GLY A 195
THR A  37
None
1.49A 4c9kA-4gpgA:
undetectable
4c9kA-4gpgA:
21.17
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4h1g MALTOSE BINDING
PROTEIN-CAKAR3 MOTOR
DOMAIN FUSION
PROTEIN


(Escherichia
coli;
Candida
albicans)
PF00225
(Kinesin)
PF13416
(SBP_bac_8)
5 THR A 654
THR A 641
LEU A 618
GLY A 619
VAL A 633
None
1.28A 4c9kA-4h1gA:
undetectable
4c9kA-4h1gA:
21.70
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4hac MEVALONATE KINASE

(Methanosarcina
mazei)
PF00288
(GHMP_kinases_N)
PF08544
(GHMP_kinases_C)
5 THR A 291
THR A 257
LEU A  31
LEU A  92
GLY A   8
None
1.31A 4c9kA-4hacA:
undetectable
4c9kA-4hacA:
23.64
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4i3g BETA-GLUCOSIDASE

(Streptomyces
venezuelae)
PF00933
(Glyco_hydro_3)
PF01915
(Glyco_hydro_3_C)
PF14310
(Fn3-like)
5 TYR A 573
THR A 590
GLY A 440
THR A 554
VAL A 546
None
SO4  A 904 (-4.5A)
None
None
None
1.28A 4c9kA-4i3gA:
undetectable
4c9kA-4i3gA:
19.40
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4j7b POLO-LIKE KINASE

(Danio rerio)
PF00069
(Pkinase)
5 THR A 146
THR A 229
LEU A 168
LEU A 165
GLY A 166
None
1.33A 4c9kA-4j7bA:
undetectable
4c9kA-4j7bA:
21.86
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4jf7 HEMAGGLUTININ-NEURAM
INIDASE


(Mammalian
rubulavirus 5)
no annotation 5 TYR D 541
LEU D 142
GLY D 143
THR D 563
VAL D 537
None
1.46A 4c9kA-4jf7D:
undetectable
4c9kA-4jf7D:
20.92
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4kl0 PUTATIVE
UNCHARACTERIZED
PROTEIN


(Xanthomonas
oryzae)
PF01156
(IU_nuc_hydro)
5 THR A 410
THR A 111
LEU A 404
LEU A 403
THR A 257
None
1.41A 4c9kA-4kl0A:
undetectable
4c9kA-4kl0A:
23.48
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4kp4 OSMOLARITY SENSOR
PROTEIN ENVZ,
HISTIDINE KINASE


(Escherichia
coli;
Thermotoga
maritima)
PF00512
(HisKA)
PF02518
(HATPase_c)
5 THR A1321
LEU A1323
LEU A1305
GLY A1306
VAL A1345
None
1.48A 4c9kA-4kp4A:
undetectable
4c9kA-4kp4A:
22.95
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4m5b COBALAMIN
BIOSYNTHESIS PROTEIN
CBIM


(Caldanaerobacter
subterraneus)
PF01891
(CbiM)
5 THR A  77
LEU A  87
LEU A  74
GLY A  70
THR A 202
HEZ  A 312 (-4.0A)
None
None
None
None
1.34A 4c9kA-4m5bA:
undetectable
4c9kA-4m5bA:
19.43
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4nsy LYSYL ENDOPEPTIDASE

(Lysobacter
enzymogenes)
PF13365
(Trypsin_2)
5 TRP A 182
THR A 189
LEU A 209
GLY A 195
THR A  37
None
2OY  A 301 (-3.6A)
2OY  A 301 ( 4.2A)
None
None
1.49A 4c9kA-4nsyA:
undetectable
4c9kA-4nsyA:
19.07
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4oli NON-RECEPTOR
TYROSINE-PROTEIN
KINASE TYK2


(Homo sapiens)
PF07714
(Pkinase_Tyr)
5 THR A 599
LEU A 767
LEU A 764
GLY A 763
THR A 658
None
1.46A 4c9kA-4oliA:
undetectable
4c9kA-4oliA:
20.82
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4q7k ABC TRANSPORTER

(Thermotoga
maritima)
PF00005
(ABC_tran)
5 THR A 521
THR A 530
LEU A 512
LEU A 509
THR A 497
None
1.16A 4c9kA-4q7kA:
undetectable
4c9kA-4q7kA:
20.75
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4rbn SUCROSE
SYNTHASE:GLYCOSYL
TRANSFERASES GROUP 1


(Nitrosomonas
europaea)
PF00534
(Glycos_transf_1)
PF00862
(Sucrose_synth)
5 THR A 708
THR A 564
LEU A 580
LEU A 577
GLY A 576
None
1.16A 4c9kA-4rbnA:
undetectable
4c9kA-4rbnA:
23.39
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4rnz CONSERVED
HYPOTHETICAL
SECRETED PROTEIN


(Helicobacter
pylori)
PF01551
(Peptidase_M23)
5 TYR A 264
THR A 233
LEU A 354
GLY A 355
VAL A 344
None
1.23A 4c9kA-4rnzA:
undetectable
4c9kA-4rnzA:
20.56
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4s1p UNCHARACTERIZED
PROTEIN


(Slackia
heliotrinireducens)
PF13472
(Lipase_GDSL_2)
5 TYR A  80
THR A 103
LEU A  38
GLY A   7
THR A  11
None
1.10A 4c9kA-4s1pA:
undetectable
4c9kA-4s1pA:
19.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4wrn MALTOSE-BINDING
PERIPLASMIC
PROTEIN,UROMODULIN


(Escherichia
coli;
Homo sapiens)
PF00100
(Zona_pellucida)
PF13416
(SBP_bac_8)
5 THR A 589
LEU A 601
LEU A 602
GLY A 641
VAL A 637
None
1.24A 4c9kA-4wrnA:
undetectable
4c9kA-4wrnA:
21.92
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4wv3 ANTHRANILATE-COA
LIGASE


(Stigmatella
aurantiaca)
PF00501
(AMP-binding)
PF13193
(AMP-binding_C)
5 TYR A 264
THR A 212
LEU A 206
LEU A 204
GLY A 205
None
1.39A 4c9kA-4wv3A:
undetectable
4c9kA-4wv3A:
22.63
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5az3 ABC-TYPE
TRANSPORTER,
PERIPLASMIC
COMPONENT


(Corynebacterium
glutamicum)
PF01497
(Peripla_BP_2)
5 THR A  69
THR A 108
LEU A 210
GLY A 207
VAL A 201
None
1.32A 4c9kA-5az3A:
undetectable
4c9kA-5az3A:
23.92
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5dfa BETA-GALACTOSIDASE

(Geobacillus
stearothermophilus)
PF02449
(Glyco_hydro_42)
PF08532
(Glyco_hydro_42M)
PF08533
(Glyco_hydro_42C)
5 THR A  48
THR A  10
LEU A 359
LEU A 320
VAL A 406
None
1.18A 4c9kA-5dfaA:
undetectable
4c9kA-5dfaA:
20.60
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ebb ACID
SPHINGOMYELINASE-LIK
E PHOSPHODIESTERASE
3A


(Homo sapiens)
PF00149
(Metallophos)
5 TYR A 168
LEU A 160
LEU A 149
GLY A 150
VAL A 125
None
1.40A 4c9kA-5ebbA:
undetectable
4c9kA-5ebbA:
21.61
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5fca ACID
SPHINGOMYELINASE-LIK
E PHOSPHODIESTERASE
3A


(Mus musculus)
PF00149
(Metallophos)
5 TYR A 165
LEU A 157
LEU A 146
GLY A 147
VAL A 122
None
1.40A 4c9kA-5fcaA:
undetectable
4c9kA-5fcaA:
22.06
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5frs SISTER CHROMATID
COHESION PROTEIN
PDS5


(Saccharomyces
cerevisiae)
PF12717
(Cnd1)
5 TYR A 157
LEU A 223
LEU A 175
GLY A 176
VAL A 185
None
1.43A 4c9kA-5frsA:
undetectable
4c9kA-5frsA:
18.99
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5iw7 RIBOSOME BIOGENESIS
PROTEIN
TSR1,RIBOSOME
BIOGENESIS PROTEIN
TSR1


(Saccharomyces
cerevisiae)
PF04950
(RIBIOP_C)
PF08142
(AARP2CN)
5 THR A 663
LEU A 585
LEU A 584
GLY A 583
VAL A 620
None
1.29A 4c9kA-5iw7A:
undetectable
4c9kA-5iw7A:
20.58
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5n9m COBYRIC ACID
SYNTHASE


(Staphylococcus
aureus)
no annotation 5 THR A  70
THR A  92
LEU A 115
LEU A 100
GLY A 101
None
1.40A 4c9kA-5n9mA:
undetectable
4c9kA-5n9mA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5nfh METHIONYL-TRNA
SYNTHETASE, PUTATIVE


(Trypanosoma
brucei)
no annotation 5 THR A 710
LEU A 606
LEU A 610
GLY A 611
VAL A 723
None
1.06A 4c9kA-5nfhA:
undetectable
4c9kA-5nfhA:
21.67
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5nfh METHIONYL-TRNA
SYNTHETASE, PUTATIVE


(Trypanosoma
brucei)
no annotation 5 THR A 710
THR A 702
LEU A 610
LEU A 613
THR A 618
None
1.22A 4c9kA-5nfhA:
undetectable
4c9kA-5nfhA:
21.67
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5nug CYTOPLASMIC DYNEIN 1
HEAVY CHAIN 1


(Homo sapiens)
PF03028
(Dynein_heavy)
PF07728
(AAA_5)
PF08393
(DHC_N2)
PF12774
(AAA_6)
PF12775
(AAA_7)
PF12777
(MT)
PF12780
(AAA_8)
PF12781
(AAA_9)
5 TRP A1741
TYR A1738
THR A1788
LEU A1815
LEU A1811
None
1.43A 4c9kA-5nugA:
undetectable
4c9kA-5nugA:
7.12
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5te7 HIV-1 GP120 CORE

(Human
immunodeficiency
virus 1)
PF00516
(GP120)
5 TRP G 338
THR G 341
LEU G 452
GLY G 451
THR G 450
None
1.32A 4c9kA-5te7G:
undetectable
4c9kA-5te7G:
19.09
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5u09 CANNABINOID RECEPTOR
1,GLGA GLYCOGEN
SYNTHASE


(Homo sapiens;
Pyrococcus
abyssi)
PF00001
(7tm_1)
PF00534
(Glycos_transf_1)
5 TRP A 279
THR A 283
LEU A 359
LEU A 360
GLY A 357
None
None
7DY  A1210 ( 4.9A)
None
None
1.40A 4c9kA-5u09A:
undetectable
4c9kA-5u09A:
22.57
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5wde KINESIN-LIKE PROTEIN
KIFC3


(Homo sapiens)
PF00225
(Kinesin)
5 THR A 739
THR A 726
LEU A 704
GLY A 705
VAL A 718
None
1.21A 4c9kA-5wdeA:
undetectable
4c9kA-5wdeA:
21.50
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5x88 CUTINASE

(Malbranchea
cinnamomea)
no annotation 5 THR A  27
THR A  99
LEU A  18
LEU A  96
VAL A 129
None
1.27A 4c9kA-5x88A:
undetectable
4c9kA-5x88A:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6bog RNA
POLYMERASE-ASSOCIATE
D PROTEIN RAPA


(Escherichia
coli)
no annotation 5 LEU A  81
LEU A  80
GLY A  79
THR A   4
VAL A  22
None
1.31A 4c9kA-6bogA:
undetectable
4c9kA-6bogA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6d7a PERFORIN-LIKE
PROTEIN 1


(Toxoplasma
gondii)
no annotation 5 THR A 961
LEU A 991
LEU A 825
GLY A 990
VAL A1028
None
1.42A 4c9kA-6d7aA:
undetectable
4c9kA-6d7aA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6f79 -

(-)
no annotation 5 TYR A 149
THR A 179
THR A 202
LEU A 145
VAL A 108
None
1.41A 4c9kA-6f79A:
undetectable
4c9kA-6f79A:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6fm7 BETA-LACTAMASE

(Aeromonas
enteropelogenes)
no annotation 5 TYR A  74
THR A 175
LEU A 171
LEU A 164
GLY A 165
None
1.28A 4c9kA-6fm7A:
undetectable
4c9kA-6fm7A:
undetectable