SIMILAR PATTERNS OF AMINO ACIDS FOR 4C9K_A_CAMA424_0
List of similar pattern of amino acids derived from ASSAM searchHit | Macromolecule/ Organism |
Pfam | Res. | Interface | HETATM | RMSD | Dali Z-score | Seq. Identity (%) | View | Dock | |
---|---|---|---|---|---|---|---|---|---|---|---|
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 1d2k | CHITINASE 1 (Coccidioidesimmitis) |
PF00704(Glyco_hydro_18) | 5 | TRP A 377THR A 65LEU A 404LEU A 398VAL A 287 | None | 1.34A | 4c9kA-1d2kA:0.0 | 4c9kA-1d2kA:20.39 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 1dpp | DIPEPTIDE BINDINGPROTEIN (Escherichiacoli) |
PF00496(SBP_bac_5) | 5 | THR A 44THR A 313LEU A 496LEU A 262GLY A 407 | None | 1.45A | 4c9kA-1dppA:0.0 | 4c9kA-1dppA:21.57 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 1hxi | PEROXISOME TARGETINGSIGNAL 1 RECEPTORPEX5 (Trypanosomabrucei) |
no annotation | 5 | THR A 392LEU A 360LEU A 357GLY A 356VAL A 375 | None | 1.45A | 4c9kA-1hxiA:undetectable | 4c9kA-1hxiA:14.96 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 1ibq | ASPERGILLOPEPSIN (Aspergillusphoenicis) |
PF00026(Asp) | 5 | TYR A 164THR A 215LEU A 121GLY A 122THR A 138 | None | 1.12A | 4c9kA-1ibqA:undetectable | 4c9kA-1ibqA:21.82 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 1ize | ASPARTIC PROTEINASE (Aspergillusoryzae) |
PF00026(Asp) | 5 | TYR A 165THR A 215LEU A 122GLY A 123THR A 139 | None | 1.13A | 4c9kA-1izeA:undetectable | 4c9kA-1izeA:21.15 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 1n0w | DNA REPAIR PROTEINRAD51 HOMOLOG 1 (Homo sapiens) |
PF08423(Rad51) | 5 | THR A 298LEU A 109LEU A 113GLY A 116VAL A 264 | NoneNone MG A 401 (-4.2A) MG A 401 (-3.8A)None | 1.08A | 4c9kA-1n0wA:0.0 | 4c9kA-1n0wA:21.41 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 1nrw | HYPOTHETICALPROTEIN, HALOACIDDEHALOGENASE-LIKEHYDROLASE (Bacillussubtilis) |
PF08282(Hydrolase_3) | 5 | THR A 269LEU A 245GLY A 236THR A 11VAL A 277 | None | 1.49A | 4c9kA-1nrwA:0.0 | 4c9kA-1nrwA:22.14 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 1s9u | PUTATIVE COMPONENTOF ANAEROBICDEHYDROGENASES (Salmonellaenterica) |
PF02613(Nitrate_red_del) | 5 | TRP A 46THR A 185LEU A 20LEU A 17GLY A 18 | None | 1.47A | 4c9kA-1s9uA:0.0 | 4c9kA-1s9uA:20.00 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 1szp | DNA REPAIR PROTEINRAD51 (Saccharomycescerevisiae) |
PF08423(Rad51)PF14520(HHH_5) | 5 | THR A 356LEU A 167LEU A 171GLY A 174VAL A 322 | None | 1.07A | 4c9kA-1szpA:undetectable | 4c9kA-1szpA:24.31 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 1udx | THE GTP-BINDINGPROTEIN OBG (Thermusthermophilus) |
PF01018(GTP1_OBG)PF01926(MMR_HSR1)PF09269(DUF1967) | 5 | THR A 208LEU A 162GLY A 161THR A 236VAL A 323 | None | 1.46A | 4c9kA-1udxA:0.0 | 4c9kA-1udxA:25.26 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 1umg | 385AA LONG CONSERVEDHYPOTHETICAL PROTEIN (Sulfurisphaeratokodaii) |
PF01950(FBPase_3) | 5 | THR A 49LEU A 292LEU A 293GLY A 294VAL A 8 | None | 1.25A | 4c9kA-1umgA:undetectable | 4c9kA-1umgA:23.50 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 1v6c | ALKALINE SERINEPROTEASE (Pseudoalteromonassp. AS-11) |
PF00082(Peptidase_S8)PF02225(PA) | 5 | THR A 352LEU A 257LEU A 278THR A 340VAL A 231 | None | 1.44A | 4c9kA-1v6cA:undetectable | 4c9kA-1v6cA:19.31 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 1vko | INOSITOL-3-PHOSPHATESYNTHASE (Caenorhabditiselegans) |
PF01658(Inos-1-P_synth)PF07994(NAD_binding_5) | 5 | THR A 292LEU A 300LEU A 297GLY A 296VAL A 267 | None | 1.43A | 4c9kA-1vkoA:undetectable | 4c9kA-1vkoA:21.68 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 1y1p | ALDEHYDE REDUCTASEII (Sporidiobolussalmonicolor) |
PF01370(Epimerase) | 5 | THR A 312LEU A 316LEU A 319GLY A 326VAL A 248 | None | 1.27A | 4c9kA-1y1pA:undetectable | 4c9kA-1y1pA:21.08 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 1yqd | SINAPYL ALCOHOLDEHYDROGENASE (Populustremuloides) |
PF00107(ADH_zinc_N)PF08240(ADH_N) | 5 | THR A 211LEU A 268LEU A 248GLY A 250VAL A 190 | None | 1.37A | 4c9kA-1yqdA:undetectable | 4c9kA-1yqdA:22.10 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 2ego | GENERAL RECEPTOR FORPHOSPHOINOSITIDES1-ASSOCIATEDSCAFFOLD PROTEIN (Rattusnorvegicus) |
PF00595(PDZ) | 5 | THR A 185LEU A 101GLY A 147THR A 149VAL A 134 | None | 1.33A | 4c9kA-2egoA:undetectable | 4c9kA-2egoA:14.64 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 2jek | RV1873 (Mycobacteriumtuberculosis) |
PF08837(DUF1810) | 5 | THR A 116THR A 82LEU A 69LEU A 78GLY A 75 | None | 1.41A | 4c9kA-2jekA:undetectable | 4c9kA-2jekA:18.62 | ||
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target. | 2m56 | CAMPHOR5-MONOOXYGENASE (Pseudomonasputida) |
PF00067(p450) | 5 | THR A 181LEU A 244GLY A 248THR A 252VAL A 396 | NoneHEM A 501 (-4.5A)HEM A 501 (-3.9A)HEM A 501 (-3.4A)None | 1.30A | 4c9kA-2m56A:57.9 | 4c9kA-2m56A:44.44 | ||
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target. | 2m56 | CAMPHOR5-MONOOXYGENASE (Pseudomonasputida) |
PF00067(p450) | 5 | TYR A 96LEU A 244GLY A 248THR A 252VAL A 396 | CAM A 502 (-4.5A)HEM A 501 (-4.5A)HEM A 501 (-3.9A)HEM A 501 (-3.4A)None | 1.28A | 4c9kA-2m56A:57.9 | 4c9kA-2m56A:44.44 | ||
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target. | 2m56 | CAMPHOR5-MONOOXYGENASE (Pseudomonasputida) |
PF00067(p450) | 7 | TYR A 96THR A 101THR A 185LEU A 244GLY A 248THR A 252VAL A 295 | CAM A 502 (-4.5A)HEM A 501 (-2.9A)NoneHEM A 501 (-4.5A)HEM A 501 (-3.9A)HEM A 501 (-3.4A)HEM A 501 (-4.6A) | 0.51A | 4c9kA-2m56A:57.9 | 4c9kA-2m56A:44.44 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 2ql8 | PUTATIVE REDOXPROTEIN (Lactobacillusparacasei) |
PF02566(OsmC) | 5 | THR A 136LEU A 63GLY A 76THR A 75VAL A 104 | None | 1.42A | 4c9kA-2ql8A:undetectable | 4c9kA-2ql8A:16.39 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 2rq6 | ATP SYNTHASE EPSILONCHAIN (Thermosynechococcuselongatus) |
PF00401(ATP-synt_DE)PF02823(ATP-synt_DE_N) | 5 | THR A 42LEU A 24LEU A 31GLY A 32VAL A 69 | None | 1.14A | 4c9kA-2rq6A:undetectable | 4c9kA-2rq6A:15.12 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 2v9q | ROUNDABOUT HOMOLOG 1 (Homo sapiens) |
PF07679(I-set)PF13927(Ig_3) | 5 | THR A 110THR A 86LEU A 121LEU A 122GLY A 125 | None | 1.38A | 4c9kA-2v9qA:undetectable | 4c9kA-2v9qA:19.50 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 2v9t | ROUNDABOUT HOMOLOG 1 (Homo sapiens) |
PF13927(Ig_3) | 5 | THR A 110THR A 86LEU A 121LEU A 122GLY A 125 | None | 1.48A | 4c9kA-2v9tA:undetectable | 4c9kA-2v9tA:14.50 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 2waa | XYLAN ESTERASE,PUTATIVE, AXE2C (Cellvibriojaponicus) |
PF13472(Lipase_GDSL_2) | 5 | TYR A 252THR A 271LEU A 202GLY A 139THR A 143 | None | 1.44A | 4c9kA-2waaA:undetectable | 4c9kA-2waaA:22.97 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 2wed | PENICILLOPEPSIN (Penicilliumjanthinellum) |
PF00026(Asp) | 5 | TYR A 165THR A 214LEU A 122GLY A 123THR A 139 | None | 1.22A | 4c9kA-2wedA:undetectable | 4c9kA-2wedA:20.23 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 2wkn | FORMAMIDASE (Delftiaacidovorans) |
PF03069(FmdA_AmdA) | 5 | THR A 214LEU A 154GLY A 249THR A 44VAL A 20 | None | 1.26A | 4c9kA-2wknA:undetectable | 4c9kA-2wknA:22.72 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3aoe | GLUTAMATEDEHYDROGENASE (Thermusthermophilus) |
PF00208(ELFV_dehydrog)PF02812(ELFV_dehydrog_N) | 5 | THR A 205LEU A 383LEU A 379GLY A 352VAL A 230 | None | 1.42A | 4c9kA-3aoeA:undetectable | 4c9kA-3aoeA:24.43 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3asa | LL-DIAMINOPIMELATEAMINOTRANSFERASE (Chlamydiatrachomatis) |
PF00155(Aminotran_1_2) | 5 | TRP A 247THR A 207LEU A 292LEU A 289GLY A 288 | None | 0.79A | 4c9kA-3asaA:undetectable | 4c9kA-3asaA:23.69 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3bn3 | INTERCELLULARADHESION MOLECULE 5 (Homo sapiens) |
PF03921(ICAM_N) | 5 | THR B 45THR B 38LEU B 52LEU B 36GLY B 35 | None | 1.32A | 4c9kA-3bn3B:undetectable | 4c9kA-3bn3B:19.50 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3cih | PUTATIVEALPHA-RHAMNOSIDASE (Bacteroidesthetaiotaomicron) |
PF17389(Bac_rhamnosid6H)PF17390(Bac_rhamnosid_C) | 5 | TYR A 522THR A 520THR A 555LEU A 447GLY A 445 | None | 1.49A | 4c9kA-3cihA:undetectable | 4c9kA-3cihA:19.87 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3cin | MYO-INOSITOL-1-PHOSPHATESYNTHASE-RELATEDPROTEIN (Thermotogamaritima) |
PF01658(Inos-1-P_synth)PF07994(NAD_binding_5) | 5 | THR A 211THR A 130LEU A 324GLY A 321THR A 15 | NAD A 400 (-3.5A)NoneNoneNoneNone | 1.10A | 4c9kA-3cinA:undetectable | 4c9kA-3cinA:23.01 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3dla | GLUTAMINE-DEPENDENTNAD(+) SYNTHETASE (Mycobacteriumtuberculosis) |
PF00795(CN_hydrolase)PF02540(NAD_synthase) | 5 | TYR A 7THR A 276LEU A 310LEU A 166VAL A 196 | None | 1.26A | 4c9kA-3dlaA:undetectable | 4c9kA-3dlaA:21.27 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3fha | ENDO-BETA-N-ACETYLGLUCOSAMINIDASE (Glutamicibacterprotophormiae) |
PF03644(Glyco_hydro_85) | 5 | TRP A 282LEU A 55LEU A 296GLY A 297VAL A 271 | None | 1.25A | 4c9kA-3fhaA:undetectable | 4c9kA-3fhaA:21.71 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3i4k | MUCONATE LACTONIZINGENZYME (Corynebacteriumglutamicum) |
PF02746(MR_MLE_N)PF13378(MR_MLE_C) | 5 | TYR A 340LEU A 336GLY A 332THR A 303VAL A 54 | TYR A 340 ( 1.3A)LEU A 336 ( 0.6A)GLY A 332 ( 0.0A)THR A 303 (-0.8A)VAL A 54 ( 0.6A) | 1.28A | 4c9kA-3i4kA:undetectable | 4c9kA-3i4kA:23.33 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3jb9 | PRE-MRNA-SPLICINGFACTOR CWF11 (Schizosaccharomycespombe) |
PF13087(AAA_12)PF16399(Aquarius_N) | 5 | THR X 774LEU X 765LEU X 761GLY X 738THR X 744 | None | 1.28A | 4c9kA-3jb9X:undetectable | 4c9kA-3jb9X:14.76 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3lda | DNA REPAIR PROTEINRAD51 (Saccharomycescerevisiae) |
PF08423(Rad51)PF14520(HHH_5) | 5 | THR A 356LEU A 167LEU A 171GLY A 174VAL A 322 | None | 1.08A | 4c9kA-3ldaA:undetectable | 4c9kA-3ldaA:24.52 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3ogz | UDP-SUGARPYROPHOSPHORYLASE (Leishmaniamajor) |
PF01704(UDPGP) | 5 | THR A 115LEU A 284GLY A 108THR A 109VAL A 158 | None | 1.48A | 4c9kA-3ogzA:undetectable | 4c9kA-3ogzA:22.14 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3ogz | UDP-SUGARPYROPHOSPHORYLASE (Leishmaniamajor) |
PF01704(UDPGP) | 5 | TRP A 154THR A 115THR A 277LEU A 284THR A 361 | None | 1.45A | 4c9kA-3ogzA:undetectable | 4c9kA-3ogzA:22.14 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3p11 | RECEPTORTYROSINE-PROTEINKINASE ERBB-3 (Homo sapiens) |
PF00757(Furin-like)PF01030(Recep_L_domain)PF14843(GF_recep_IV) | 5 | THR A 13THR A 49LEU A 33LEU A 30VAL A 19 | None | 1.41A | 4c9kA-3p11A:undetectable | 4c9kA-3p11A:19.93 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3sh5 | LG3 PEPTIDE (Homo sapiens) |
PF00054(Laminin_G_1) | 5 | THR A 40LEU A 73LEU A 68GLY A 67VAL A 160 | None | 1.15A | 4c9kA-3sh5A:undetectable | 4c9kA-3sh5A:22.19 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3t4c | 2-DEHYDRO-3-DEOXYPHOSPHOOCTONATEALDOLASE 1 (Burkholderiaambifaria) |
PF00793(DAHP_synth_1) | 5 | TYR A 49THR A 29THR A 89LEU A 76GLY A 72 | None | 0.96A | 4c9kA-3t4cA:undetectable | 4c9kA-3t4cA:22.51 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3uw3 | ASPARTATE-SEMIALDEHYDE DEHYDROGENASE (Burkholderiathailandensis) |
PF01118(Semialdhyde_dh)PF02774(Semialdhyde_dhC) | 5 | THR A 350LEU A 146LEU A 143GLY A 144VAL A 308 | None | 1.32A | 4c9kA-3uw3A:undetectable | 4c9kA-3uw3A:22.35 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4ad9 | BETA-LACTAMASE-LIKEPROTEIN 2 (Homo sapiens) |
PF00753(Lactamase_B) | 5 | TYR A 180THR A 172THR A 142GLY A 163THR A 76 | None | 1.07A | 4c9kA-4ad9A:undetectable | 4c9kA-4ad9A:22.27 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4amg | SNOGD (Streptomycesnogalater) |
PF06722(DUF1205) | 5 | THR A 264LEU A 291LEU A 292GLY A 289THR A 309 | None | 1.33A | 4c9kA-4amgA:undetectable | 4c9kA-4amgA:23.74 | ||
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target. | 4c9m | CYTOCHROME P450 (Novosphingobiumaromaticivorans) |
PF00067(p450) | 7 | TRP A 89TYR A 98THR A 103LEU A 252GLY A 256THR A 260VAL A 404 | NoneNoneGOL A1419 (-3.8A)HEM A1418 (-4.0A)HEM A1418 (-3.8A)HEM A1418 (-3.6A)GOL A1419 (-3.5A) | 1.34A | 4c9kA-4c9mA:72.4 | 4c9kA-4c9mA:100.00 | ||
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target. | 4c9m | CYTOCHROME P450 (Novosphingobiumaromaticivorans) |
PF00067(p450) | 9 | TRP A 89TYR A 98THR A 103THR A 187LEU A 252LEU A 255GLY A 256THR A 260VAL A 303 | NoneNoneGOL A1419 (-3.8A)NoneHEM A1418 (-4.0A)GOL A1419 ( 4.9A)HEM A1418 (-3.8A)HEM A1418 (-3.6A)GOL A1419 (-3.9A) | 0.15A | 4c9kA-4c9mA:72.4 | 4c9kA-4c9mA:100.00 | ||
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target. | 4dxy | CYTOCHROME P450 (Novosphingobiumaromaticivorans) |
PF00067(p450) | 5 | THR A 101LEU A 250GLY A 254THR A 258VAL A 301 | HEM A 501 ( 4.8A)HEM A 501 (-4.3A)PEG A 502 (-3.8A)HEM A 501 (-3.7A)PEG A 502 ( 4.5A) | 0.93A | 4c9kA-4dxyA:55.5 | 4c9kA-4dxyA:61.24 | ||
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target. | 4dxy | CYTOCHROME P450 (Novosphingobiumaromaticivorans) |
PF00067(p450) | 5 | THR A 101THR A 185LEU A 250GLY A 254THR A 258 | HEM A 501 ( 4.8A)NoneHEM A 501 (-4.3A)PEG A 502 (-3.8A)HEM A 501 (-3.7A) | 1.12A | 4c9kA-4dxyA:55.5 | 4c9kA-4dxyA:61.24 | ||
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target. | 4dxy | CYTOCHROME P450 (Novosphingobiumaromaticivorans) |
PF00067(p450) | 5 | THR A 101THR A 185LEU A 250LEU A 253GLY A 254 | HEM A 501 ( 4.8A)NoneHEM A 501 (-4.3A)NonePEG A 502 (-3.8A) | 1.17A | 4c9kA-4dxyA:55.5 | 4c9kA-4dxyA:61.24 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4gpg | PROTEASE 1 (Achromobacterlyticus) |
PF00089(Trypsin) | 5 | TRP A 182THR A 189LEU A 209GLY A 195THR A 37 | None | 1.49A | 4c9kA-4gpgA:undetectable | 4c9kA-4gpgA:21.17 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4h1g | MALTOSE BINDINGPROTEIN-CAKAR3 MOTORDOMAIN FUSIONPROTEIN (Escherichiacoli;Candidaalbicans) |
PF00225(Kinesin)PF13416(SBP_bac_8) | 5 | THR A 654THR A 641LEU A 618GLY A 619VAL A 633 | None | 1.28A | 4c9kA-4h1gA:undetectable | 4c9kA-4h1gA:21.70 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4hac | MEVALONATE KINASE (Methanosarcinamazei) |
PF00288(GHMP_kinases_N)PF08544(GHMP_kinases_C) | 5 | THR A 291THR A 257LEU A 31LEU A 92GLY A 8 | None | 1.31A | 4c9kA-4hacA:undetectable | 4c9kA-4hacA:23.64 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4i3g | BETA-GLUCOSIDASE (Streptomycesvenezuelae) |
PF00933(Glyco_hydro_3)PF01915(Glyco_hydro_3_C)PF14310(Fn3-like) | 5 | TYR A 573THR A 590GLY A 440THR A 554VAL A 546 | NoneSO4 A 904 (-4.5A)NoneNoneNone | 1.28A | 4c9kA-4i3gA:undetectable | 4c9kA-4i3gA:19.40 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4j7b | POLO-LIKE KINASE (Danio rerio) |
PF00069(Pkinase) | 5 | THR A 146THR A 229LEU A 168LEU A 165GLY A 166 | None | 1.33A | 4c9kA-4j7bA:undetectable | 4c9kA-4j7bA:21.86 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4jf7 | HEMAGGLUTININ-NEURAMINIDASE (Mammalianrubulavirus 5) |
no annotation | 5 | TYR D 541LEU D 142GLY D 143THR D 563VAL D 537 | None | 1.46A | 4c9kA-4jf7D:undetectable | 4c9kA-4jf7D:20.92 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4kl0 | PUTATIVEUNCHARACTERIZEDPROTEIN (Xanthomonasoryzae) |
PF01156(IU_nuc_hydro) | 5 | THR A 410THR A 111LEU A 404LEU A 403THR A 257 | None | 1.41A | 4c9kA-4kl0A:undetectable | 4c9kA-4kl0A:23.48 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4kp4 | OSMOLARITY SENSORPROTEIN ENVZ,HISTIDINE KINASE (Escherichiacoli;Thermotogamaritima) |
PF00512(HisKA)PF02518(HATPase_c) | 5 | THR A1321LEU A1323LEU A1305GLY A1306VAL A1345 | None | 1.48A | 4c9kA-4kp4A:undetectable | 4c9kA-4kp4A:22.95 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4m5b | COBALAMINBIOSYNTHESIS PROTEINCBIM (Caldanaerobactersubterraneus) |
PF01891(CbiM) | 5 | THR A 77LEU A 87LEU A 74GLY A 70THR A 202 | HEZ A 312 (-4.0A)NoneNoneNoneNone | 1.34A | 4c9kA-4m5bA:undetectable | 4c9kA-4m5bA:19.43 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4nsy | LYSYL ENDOPEPTIDASE (Lysobacterenzymogenes) |
PF13365(Trypsin_2) | 5 | TRP A 182THR A 189LEU A 209GLY A 195THR A 37 | None2OY A 301 (-3.6A)2OY A 301 ( 4.2A)NoneNone | 1.49A | 4c9kA-4nsyA:undetectable | 4c9kA-4nsyA:19.07 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4oli | NON-RECEPTORTYROSINE-PROTEINKINASE TYK2 (Homo sapiens) |
PF07714(Pkinase_Tyr) | 5 | THR A 599LEU A 767LEU A 764GLY A 763THR A 658 | None | 1.46A | 4c9kA-4oliA:undetectable | 4c9kA-4oliA:20.82 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4q7k | ABC TRANSPORTER (Thermotogamaritima) |
PF00005(ABC_tran) | 5 | THR A 521THR A 530LEU A 512LEU A 509THR A 497 | None | 1.16A | 4c9kA-4q7kA:undetectable | 4c9kA-4q7kA:20.75 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4rbn | SUCROSESYNTHASE:GLYCOSYLTRANSFERASES GROUP 1 (Nitrosomonaseuropaea) |
PF00534(Glycos_transf_1)PF00862(Sucrose_synth) | 5 | THR A 708THR A 564LEU A 580LEU A 577GLY A 576 | None | 1.16A | 4c9kA-4rbnA:undetectable | 4c9kA-4rbnA:23.39 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4rnz | CONSERVEDHYPOTHETICALSECRETED PROTEIN (Helicobacterpylori) |
PF01551(Peptidase_M23) | 5 | TYR A 264THR A 233LEU A 354GLY A 355VAL A 344 | None | 1.23A | 4c9kA-4rnzA:undetectable | 4c9kA-4rnzA:20.56 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4s1p | UNCHARACTERIZEDPROTEIN (Slackiaheliotrinireducens) |
PF13472(Lipase_GDSL_2) | 5 | TYR A 80THR A 103LEU A 38GLY A 7THR A 11 | None | 1.10A | 4c9kA-4s1pA:undetectable | 4c9kA-4s1pA:19.00 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4wrn | MALTOSE-BINDINGPERIPLASMICPROTEIN,UROMODULIN (Escherichiacoli;Homo sapiens) |
PF00100(Zona_pellucida)PF13416(SBP_bac_8) | 5 | THR A 589LEU A 601LEU A 602GLY A 641VAL A 637 | None | 1.24A | 4c9kA-4wrnA:undetectable | 4c9kA-4wrnA:21.92 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4wv3 | ANTHRANILATE-COALIGASE (Stigmatellaaurantiaca) |
PF00501(AMP-binding)PF13193(AMP-binding_C) | 5 | TYR A 264THR A 212LEU A 206LEU A 204GLY A 205 | None | 1.39A | 4c9kA-4wv3A:undetectable | 4c9kA-4wv3A:22.63 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 5az3 | ABC-TYPETRANSPORTER,PERIPLASMICCOMPONENT (Corynebacteriumglutamicum) |
PF01497(Peripla_BP_2) | 5 | THR A 69THR A 108LEU A 210GLY A 207VAL A 201 | None | 1.32A | 4c9kA-5az3A:undetectable | 4c9kA-5az3A:23.92 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 5dfa | BETA-GALACTOSIDASE (Geobacillusstearothermophilus) |
PF02449(Glyco_hydro_42)PF08532(Glyco_hydro_42M)PF08533(Glyco_hydro_42C) | 5 | THR A 48THR A 10LEU A 359LEU A 320VAL A 406 | None | 1.18A | 4c9kA-5dfaA:undetectable | 4c9kA-5dfaA:20.60 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 5ebb | ACIDSPHINGOMYELINASE-LIKE PHOSPHODIESTERASE3A (Homo sapiens) |
PF00149(Metallophos) | 5 | TYR A 168LEU A 160LEU A 149GLY A 150VAL A 125 | None | 1.40A | 4c9kA-5ebbA:undetectable | 4c9kA-5ebbA:21.61 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 5fca | ACIDSPHINGOMYELINASE-LIKE PHOSPHODIESTERASE3A (Mus musculus) |
PF00149(Metallophos) | 5 | TYR A 165LEU A 157LEU A 146GLY A 147VAL A 122 | None | 1.40A | 4c9kA-5fcaA:undetectable | 4c9kA-5fcaA:22.06 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 5frs | SISTER CHROMATIDCOHESION PROTEINPDS5 (Saccharomycescerevisiae) |
PF12717(Cnd1) | 5 | TYR A 157LEU A 223LEU A 175GLY A 176VAL A 185 | None | 1.43A | 4c9kA-5frsA:undetectable | 4c9kA-5frsA:18.99 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 5iw7 | RIBOSOME BIOGENESISPROTEINTSR1,RIBOSOMEBIOGENESIS PROTEINTSR1 (Saccharomycescerevisiae) |
PF04950(RIBIOP_C)PF08142(AARP2CN) | 5 | THR A 663LEU A 585LEU A 584GLY A 583VAL A 620 | None | 1.29A | 4c9kA-5iw7A:undetectable | 4c9kA-5iw7A:20.58 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 5n9m | COBYRIC ACIDSYNTHASE (Staphylococcusaureus) |
no annotation | 5 | THR A 70THR A 92LEU A 115LEU A 100GLY A 101 | None | 1.40A | 4c9kA-5n9mA:undetectable | 4c9kA-5n9mA:undetectable | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 5nfh | METHIONYL-TRNASYNTHETASE, PUTATIVE (Trypanosomabrucei) |
no annotation | 5 | THR A 710LEU A 606LEU A 610GLY A 611VAL A 723 | None | 1.06A | 4c9kA-5nfhA:undetectable | 4c9kA-5nfhA:21.67 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 5nfh | METHIONYL-TRNASYNTHETASE, PUTATIVE (Trypanosomabrucei) |
no annotation | 5 | THR A 710THR A 702LEU A 610LEU A 613THR A 618 | None | 1.22A | 4c9kA-5nfhA:undetectable | 4c9kA-5nfhA:21.67 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 5nug | CYTOPLASMIC DYNEIN 1HEAVY CHAIN 1 (Homo sapiens) |
PF03028(Dynein_heavy)PF07728(AAA_5)PF08393(DHC_N2)PF12774(AAA_6)PF12775(AAA_7)PF12777(MT)PF12780(AAA_8)PF12781(AAA_9) | 5 | TRP A1741TYR A1738THR A1788LEU A1815LEU A1811 | None | 1.43A | 4c9kA-5nugA:undetectable | 4c9kA-5nugA:7.12 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 5te7 | HIV-1 GP120 CORE (Humanimmunodeficiencyvirus 1) |
PF00516(GP120) | 5 | TRP G 338THR G 341LEU G 452GLY G 451THR G 450 | None | 1.32A | 4c9kA-5te7G:undetectable | 4c9kA-5te7G:19.09 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 5u09 | CANNABINOID RECEPTOR1,GLGA GLYCOGENSYNTHASE (Homo sapiens;Pyrococcusabyssi) |
PF00001(7tm_1)PF00534(Glycos_transf_1) | 5 | TRP A 279THR A 283LEU A 359LEU A 360GLY A 357 | NoneNone7DY A1210 ( 4.9A)NoneNone | 1.40A | 4c9kA-5u09A:undetectable | 4c9kA-5u09A:22.57 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 5wde | KINESIN-LIKE PROTEINKIFC3 (Homo sapiens) |
PF00225(Kinesin) | 5 | THR A 739THR A 726LEU A 704GLY A 705VAL A 718 | None | 1.21A | 4c9kA-5wdeA:undetectable | 4c9kA-5wdeA:21.50 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 5x88 | CUTINASE (Malbrancheacinnamomea) |
no annotation | 5 | THR A 27THR A 99LEU A 18LEU A 96VAL A 129 | None | 1.27A | 4c9kA-5x88A:undetectable | 4c9kA-5x88A:undetectable | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 6bog | RNAPOLYMERASE-ASSOCIATED PROTEIN RAPA (Escherichiacoli) |
no annotation | 5 | LEU A 81LEU A 80GLY A 79THR A 4VAL A 22 | None | 1.31A | 4c9kA-6bogA:undetectable | 4c9kA-6bogA:undetectable | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 6d7a | PERFORIN-LIKEPROTEIN 1 (Toxoplasmagondii) |
no annotation | 5 | THR A 961LEU A 991LEU A 825GLY A 990VAL A1028 | None | 1.42A | 4c9kA-6d7aA:undetectable | 4c9kA-6d7aA:undetectable | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 6f79 | - (-) |
no annotation | 5 | TYR A 149THR A 179THR A 202LEU A 145VAL A 108 | None | 1.41A | 4c9kA-6f79A:undetectable | 4c9kA-6f79A:undetectable | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 6fm7 | BETA-LACTAMASE (Aeromonasenteropelogenes) |
no annotation | 5 | TYR A 74THR A 175LEU A 171LEU A 164GLY A 165 | None | 1.28A | 4c9kA-6fm7A:undetectable | 4c9kA-6fm7A:undetectable |