SIMILAR PATTERNS OF AMINO ACIDS FOR 4C8B_B_0LIB1000_2

List of similar pattern of amino acids derived from ASSAM search

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click link on the last column to view superposed patterns of amino acids in NGL viewer)
(Note that only 3-12 residue patterns can be used for ASSAM searches)
Filter list by:
Hit Macromolecule/
Organism		 Pfam Res. Interface HETATM RMSD Dali Z-score Seq. Identity (%) View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1a1s ORNITHINE
CARBAMOYLTRANSFERASE

(Pyrococcus
furiosus) 		PF00185
(OTCace)
PF02729
(OTCace_N) 		3 TYR A 264
MET A 265
ILE A 152
 None
 0.81A 4c8bB-1a1sA:
undetectable		 4c8bB-1a1sA:
21.82
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1aug PYROGLUTAMYL
PEPTIDASE-1

(Bacillus
amyloliquefaciens) 		PF01470
(Peptidase_C15) 		3 TYR A 113
MET A 152
ILE A  65
 None
 0.86A 4c8bB-1augA:
undetectable		 4c8bB-1augA:
21.13
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ijq LOW-DENSITY
LIPOPROTEIN RECEPTOR

(Homo sapiens) 		PF00058
(Ldl_recept_b)
PF14670
(FXa_inhibition) 		3 TYR A 511
MET A 510
ILE A 467
 None
 0.74A 4c8bB-1ijqA:
undetectable		 4c8bB-1ijqA:
20.61
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1luf MUSCLE-SPECIFIC
TYROSINE KINASE
RECEPTOR MUSK

(Rattus
norvegicus) 		PF07714
(Pkinase_Tyr) 		3 TYR A 656
MET A 657
ILE A 637
 None
 0.55A 4c8bB-1lufA:
27.3		 4c8bB-1lufA:
27.42
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1luf MUSCLE-SPECIFIC
TYROSINE KINASE
RECEPTOR MUSK

(Rattus
norvegicus) 		PF07714
(Pkinase_Tyr) 		3 TYR A 656
MET A 657
ILE A 740
 None
 0.19A 4c8bB-1lufA:
27.3		 4c8bB-1lufA:
27.42
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1mox EPIDERMAL GROWTH
FACTOR RECEPTOR

(Homo sapiens) 		PF00757
(Furin-like)
PF01030
(Recep_L_domain) 		3 TYR A  88
MET A  87
ILE A 318
 None
 0.89A 4c8bB-1moxA:
undetectable		 4c8bB-1moxA:
21.39
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1n7d LOW-DENSITY
LIPOPROTEIN RECEPTOR

(Homo sapiens) 		PF00057
(Ldl_recept_a)
PF00058
(Ldl_recept_b)
PF07645
(EGF_CA)
PF14670
(FXa_inhibition) 		3 TYR A 511
MET A 510
ILE A 467
 None
 0.91A 4c8bB-1n7dA:
undetectable		 4c8bB-1n7dA:
17.14
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1o5w AMINE OXIDASE
[FLAVIN-CONTAINING]
A

(Rattus
norvegicus) 		PF01593
(Amino_oxidase) 		3 TYR A 410
MET A 300
ILE A 273
 None
None
FAD  A 652 (-3.6A)
 0.76A 4c8bB-1o5wA:
undetectable		 4c8bB-1o5wA:
22.55
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1zdx OUTER MEMBRANE USHER
PROTEIN FIMD

(Escherichia
coli) 		PF13954
(PapC_N) 		3 TYR A  43
MET A  44
ILE A 115
 None
 0.77A 4c8bB-1zdxA:
undetectable		 4c8bB-1zdxA:
18.02
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2a3n PUTATIVE
GLUCOSAMINE-FRUCTOSE
-6-PHOSPHATE
AMINOTRANSFERASE

(Salmonella
enterica) 		PF01380
(SIS) 		3 TYR A 208
MET A 209
ILE A 228
 None
 0.78A 4c8bB-2a3nA:
undetectable		 4c8bB-2a3nA:
22.37
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2ajr SUGAR KINASE, PFKB
FAMILY

(Thermotoga
maritima) 		PF00294
(PfkB) 		3 TYR A 299
MET A 300
ILE A  43
 None
 0.56A 4c8bB-2ajrA:
undetectable		 4c8bB-2ajrA:
24.40
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2dq7 PROTO-ONCOGENE
TYROSINE-PROTEIN
KINASE FYN

(Homo sapiens) 		PF07714
(Pkinase_Tyr) 		3 TYR X  84
MET X  85
ILE X 146
 STU  X 902 (-4.6A)
None
None
 0.16A 4c8bB-2dq7X:
26.3		 4c8bB-2dq7X:
26.11
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2ehj URACIL
PHOSPHORIBOSYLTRANSF
ERASE

(Escherichia
coli) 		PF14681
(UPRTase) 		3 TYR A 113
MET A 101
ILE A 143
 None
 0.68A 4c8bB-2ehjA:
undetectable		 4c8bB-2ehjA:
22.29
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2eqn HYPOTHETICAL PROTEIN
LOC92345

(Homo sapiens) 		PF04410
(Gar1) 		3 TYR A 101
MET A 100
ILE A  89
 None
 0.72A 4c8bB-2eqnA:
undetectable		 4c8bB-2eqnA:
14.76
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2fl1 RED FLUORESCENT
PROTEIN ZOANRFP

(Zoanthus sp.) 		PF01353
(GFP) 		3 TYR A 168
MET A 167
ILE A 200
 None
XYG  A  66 ( 3.2A)
None
 0.66A 4c8bB-2fl1A:
undetectable		 4c8bB-2fl1A:
18.90
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2ggt SCO1 PROTEIN
HOMOLOG,
MITOCHONDRIAL

(Homo sapiens) 		PF02630
(SCO1-SenC) 		3 TYR A 265
MET A 264
ILE A 181
 None
 0.88A 4c8bB-2ggtA:
undetectable		 4c8bB-2ggtA:
19.70
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2i6l MITOGEN-ACTIVATED
PROTEIN KINASE 6

(Homo sapiens) 		PF00069
(Pkinase) 		3 TYR A 110
MET A 111
ILE A  77
 None
 0.76A 4c8bB-2i6lA:
21.9		 4c8bB-2i6lA:
26.52
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2i6l MITOGEN-ACTIVATED
PROTEIN KINASE 6

(Homo sapiens) 		PF00069
(Pkinase) 		3 TYR A 110
MET A 111
ILE A 169
 None
 0.29A 4c8bB-2i6lA:
21.9		 4c8bB-2i6lA:
26.52
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2og8 PROTO-ONCOGENE
TYROSINE-PROTEIN
KINASE LCK

(Homo sapiens) 		PF07714
(Pkinase_Tyr) 		3 TYR A 318
MET A 319
ILE A 380
 1N8  A 501 ( 3.7A)
1N8  A 501 ( 4.4A)
None
 0.49A 4c8bB-2og8A:
27.1		 4c8bB-2og8A:
26.61
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2ogr FLUORESCENT PROTEIN
FP538

(Zoanthus sp.) 		PF01353
(GFP) 		3 TYR A 168
MET A 167
ILE A 200
 None
CH7  A  66 ( 3.2A)
None
 0.67A 4c8bB-2ogrA:
undetectable		 4c8bB-2ogrA:
22.02
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2okx RHAMNOSIDASE B

(Bacillus sp.
GL1) 		PF05592
(Bac_rhamnosid)
PF08531
(Bac_rhamnosid_N)
PF17389
(Bac_rhamnosid6H)
PF17390
(Bac_rhamnosid_C) 		3 TYR A 470
MET A 471
ILE A 441
 None
 0.62A 4c8bB-2okxA:
undetectable		 4c8bB-2okxA:
15.45
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2pmo SER/THR PROTEIN
KINASE

(Plasmodium
falciparum) 		PF00069
(Pkinase) 		3 TYR X 119
MET X 120
ILE X 178
 HMD  X 400 (-4.5A)
None
None
 0.92A 4c8bB-2pmoX:
3.2		 4c8bB-2pmoX:
25.53
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2pxs GFP-LIKE FLUORESCENT
CHROMOPROTEIN FP506

(Zoanthus sp.) 		PF01353
(GFP) 		3 TYR A 168
MET A 167
ILE A 200
 None
XYG  A  66 ( 3.1A)
None
 0.66A 4c8bB-2pxsA:
undetectable		 4c8bB-2pxsA:
20.30
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2qkw PROTEIN KINASE

(Solanum
pimpinellifolium) 		PF07714
(Pkinase_Tyr) 		3 TYR B 116
MET B 117
ILE B 180
 None
 0.44A 4c8bB-2qkwB:
24.6		 4c8bB-2qkwB:
30.09
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2r2p EPHRIN TYPE-A
RECEPTOR 5

(Homo sapiens) 		PF07714
(Pkinase_Tyr)
PF14575
(EphA2_TM) 		3 TYR A 755
MET A 756
ILE A 736
 None
 0.59A 4c8bB-2r2pA:
26.9		 4c8bB-2r2pA:
28.53
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2xyu EPHRIN TYPE-A
RECEPTOR 4,

(Mus musculus) 		PF07714
(Pkinase_Tyr) 		3 TYR A 701
MET A 702
ILE A 682
 Q9G  A1898 (-4.8A)
None
None
 0.58A 4c8bB-2xyuA:
27.8		 4c8bB-2xyuA:
28.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2y35 LD22664P

(Drosophila
melanogaster) 		PF03159
(XRN_N) 		3 TYR A 579
MET A 578
ILE A 180
 None
 0.72A 4c8bB-2y35A:
undetectable		 4c8bB-2y35A:
15.16
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2z5x AMINE OXIDASE
[FLAVIN-CONTAINING]
A

(Homo sapiens) 		PF01593
(Amino_oxidase) 		3 TYR A 410
MET A 300
ILE A 273
 None
None
FAD  A 600 (-3.9A)
 0.72A 4c8bB-2z5xA:
undetectable		 4c8bB-2z5xA:
20.93
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3bwu OUTER MEMBRANE USHER
PROTEIN FIMD,
N-TERMINAL DOMAIN

(Escherichia
coli) 		PF13954
(PapC_N) 		3 TYR D  43
MET D  44
ILE D 115
 None
 0.66A 4c8bB-3bwuD:
undetectable		 4c8bB-3bwuD:
18.25
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3dsb PUTATIVE
ACETYLTRANSFERASE

(Clostridioides
difficile) 		PF00583
(Acetyltransf_1) 		3 TYR A 153
MET A 152
ILE A 119
 None
 0.86A 4c8bB-3dsbA:
undetectable		 4c8bB-3dsbA:
19.27
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3gab DNA MISMATCH REPAIR
PROTEIN MUTL

(Bacillus
subtilis) 		PF08676
(MutL_C) 		3 TYR A 440
MET A 439
ILE A 612
 None
 0.81A 4c8bB-3gabA:
undetectable		 4c8bB-3gabA:
21.73
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3h0g DNA-DIRECTED RNA
POLYMERASE II
SUBUNIT RPB2

(Schizosaccharomyces
pombe) 		PF00562
(RNA_pol_Rpb2_6)
PF04560
(RNA_pol_Rpb2_7)
PF04561
(RNA_pol_Rpb2_2)
PF04563
(RNA_pol_Rpb2_1)
PF04565
(RNA_pol_Rpb2_3)
PF04566
(RNA_pol_Rpb2_4)
PF04567
(RNA_pol_Rpb2_5) 		3 TYR B1062
MET B1061
ILE B 813
 None
 0.92A 4c8bB-3h0gB:
undetectable		 4c8bB-3h0gB:
14.40
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3hrp UNCHARACTERIZED
PROTEIN

(Bacteroides
thetaiotaomicron) 		PF01833
(TIG) 		3 TYR A 153
MET A 154
ILE A 132
 None
 0.73A 4c8bB-3hrpA:
undetectable		 4c8bB-3hrpA:
20.86
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3jur EXO-POLY-ALPHA-D-GAL
ACTURONOSIDASE

(Thermotoga
maritima) 		PF00295
(Glyco_hydro_28)
PF12708
(Pectate_lyase_3) 		3 TYR A 440
MET A 426
ILE A 430
 None
 0.91A 4c8bB-3jurA:
undetectable		 4c8bB-3jurA:
21.48
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ko7 D-TYROSYL-TRNA(TYR)
DEACYLASE

(Plasmodium
falciparum) 		PF02580
(Tyr_Deacylase) 		3 TYR A 140
MET A 141
ILE A  85
 None
 0.77A 4c8bB-3ko7A:
undetectable		 4c8bB-3ko7A:
18.26
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3kul EPHRIN TYPE-A
RECEPTOR 8

(Homo sapiens) 		PF07714
(Pkinase_Tyr)
PF14575
(EphA2_TM) 		3 TYR A 715
MET A 716
ILE A 696
 GOL  A 403 (-4.1A)
None
None
 0.67A 4c8bB-3kulA:
27.2		 4c8bB-3kulA:
31.11
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3l6n METALLO-BETA-LACTAMA
SE

(Chryseobacterium
indologenes) 		PF00753
(Lactamase_B) 		3 TYR A  38
MET A  54
ILE A 216
 None
None
SO4  A 402 (-3.0A)
 0.68A 4c8bB-3l6nA:
undetectable		 4c8bB-3l6nA:
21.08
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3lvv GLUTAMATE--CYSTEINE
LIGASE

(Saccharomyces
cerevisiae) 		PF03074
(GCS) 		3 TYR A 254
MET A 255
ILE A 317
 None
None
LBP  A 693 (-4.7A)
 0.83A 4c8bB-3lvvA:
undetectable		 4c8bB-3lvvA:
17.31
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3m0c LOW-DENSITY
LIPOPROTEIN RECEPTOR

(Homo sapiens) 		PF00057
(Ldl_recept_a)
PF00058
(Ldl_recept_b)
PF07645
(EGF_CA)
PF14670
(FXa_inhibition) 		3 TYR C 511
MET C 510
ILE C 467
 None
 0.74A 4c8bB-3m0cC:
undetectable		 4c8bB-3m0cC:
18.53
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3mgf FLUORESCENT PROTEIN

(Verrillofungia
concinna) 		PF01353
(GFP) 		3 TYR A 163
MET A 162
ILE A 195
 None
CFY  A  66 ( 3.3A)
None
 0.67A 4c8bB-3mgfA:
undetectable		 4c8bB-3mgfA:
19.48
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3n23 SODIUM/POTASSIUM-TRA
NSPORTING ATPASE
SUBUNIT ALPHA-1

(Sus scrofa) 		PF00122
(E1-E2_ATPase)
PF00689
(Cation_ATPase_C)
PF00690
(Cation_ATPase_N)
PF13246
(Cation_ATPase) 		3 TYR A 974
MET A 973
ILE A 800
 None
None
OBN  A   1 ( 4.7A)
 0.79A 4c8bB-3n23A:
undetectable		 4c8bB-3n23A:
15.32
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3n7z ACETYLTRANSFERASE,
GNAT FAMILY

(Bacillus
anthracis) 		PF13527
(Acetyltransf_9)
PF13530
(SCP2_2) 		3 TYR A 213
MET A 214
ILE A 218
 None
 0.87A 4c8bB-3n7zA:
undetectable		 4c8bB-3n7zA:
21.12
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3oz6 MITOGEN-ACTIVATED
PROTEIN KINASE 1,
SERINE/THREONINE
PROTEIN KINASE

(Cryptosporidium
parvum) 		PF00069
(Pkinase) 		3 TYR A  92
MET A  93
ILE A  71
 None
 0.78A 4c8bB-3oz6A:
20.6		 4c8bB-3oz6A:
22.80
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3oz6 MITOGEN-ACTIVATED
PROTEIN KINASE 1,
SERINE/THREONINE
PROTEIN KINASE

(Cryptosporidium
parvum) 		PF00069
(Pkinase) 		3 TYR A  92
MET A  93
ILE A 140
 None
 0.87A 4c8bB-3oz6A:
20.6		 4c8bB-3oz6A:
22.80
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3p5b LOW DENSITY
LIPOPROTEIN RECEPTOR
VARIANT

(Homo sapiens) 		PF00058
(Ldl_recept_b)
PF07645
(EGF_CA)
PF14670
(FXa_inhibition) 		3 TYR L 511
MET L 510
ILE L 467
 None
 0.92A 4c8bB-3p5bL:
undetectable		 4c8bB-3p5bL:
21.94
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3pz9 MANNAN
ENDO-1,4-BETA-MANNOS
IDASE. GLYCOSYL
HYDROLASE FAMILY 5

(Thermotoga
petrophila) 		PF00150
(Cellulase) 		3 TYR A 318
MET A 348
ILE A  72
 None
 0.89A 4c8bB-3pz9A:
undetectable		 4c8bB-3pz9A:
22.82
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ujz METALLOPROTEASE STCE

(Escherichia
coli) 		PF10462
(Peptidase_M66) 		3 TYR A 710
MET A 709
ILE A 375
 None
 0.90A 4c8bB-3ujzA:
undetectable		 4c8bB-3ujzA:
16.82
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3v5q NT-3 GROWTH FACTOR
RECEPTOR

(Homo sapiens) 		PF07714
(Pkinase_Tyr) 		3 TYR A 619
MET A 620
ILE A 600
 0F4  A 902 (-4.2A)
None
0F4  A 902 (-4.1A)
 0.76A 4c8bB-3v5qA:
26.7		 4c8bB-3v5qA:
29.30
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3v5q NT-3 GROWTH FACTOR
RECEPTOR

(Homo sapiens) 		PF07714
(Pkinase_Tyr) 		3 TYR A 619
MET A 620
ILE A 695
 0F4  A 902 (-4.2A)
None
0F4  A 902 (-4.6A)
 0.39A 4c8bB-3v5qA:
26.7		 4c8bB-3v5qA:
29.30
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3wdy BETA-1,3-1,4-GLUCANA
SE

(Paecilomyces
sp.
'thermophila') 		no annotation 3 TYR A  52
MET A  53
ILE A 244
 None
 0.88A 4c8bB-3wdyA:
undetectable		 4c8bB-3wdyA:
22.16
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3zh4 UDP-N-ACETYLGLUCOSAM
INE
1-CARBOXYVINYLTRANSF
ERASE

(Streptococcus
pneumoniae) 		PF00275
(EPSP_synthase) 		3 TYR A 159
MET A 160
ILE A 169
 None
 0.58A 4c8bB-3zh4A:
undetectable		 4c8bB-3zh4A:
23.27
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3zq4 RIBONUCLEASE J 1

(Bacillus
subtilis) 		PF00753
(Lactamase_B)
PF07521
(RMMBL) 		3 TYR A 493
MET A 494
ILE A 468
 None
 0.76A 4c8bB-3zq4A:
undetectable		 4c8bB-3zq4A:
20.89
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4aah METHANOL
DEHYDROGENASE

(Methylophilus
methylotrophus) 		PF13360
(PQQ_2) 		3 TYR A  66
MET A  65
ILE A 522
 None
 0.88A 4c8bB-4aahA:
undetectable		 4c8bB-4aahA:
20.24
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4at3 BDNF/NT-3 GROWTH
FACTORS RECEPTOR

(Homo sapiens) 		PF07714
(Pkinase_Tyr) 		3 TYR A 635
MET A 636
ILE A 616
 LTI  A1839 (-4.7A)
None
None
 0.77A 4c8bB-4at3A:
27.2		 4c8bB-4at3A:
28.49
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4at3 BDNF/NT-3 GROWTH
FACTORS RECEPTOR

(Homo sapiens) 		PF07714
(Pkinase_Tyr) 		3 TYR A 635
MET A 636
ILE A 708
 LTI  A1839 (-4.7A)
None
None
 0.48A 4c8bB-4at3A:
27.2		 4c8bB-4at3A:
28.49
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4b9w TUDOR
DOMAIN-CONTAINING
PROTEIN 1

(Mus musculus) 		PF00567
(TUDOR) 		3 TYR A 718
MET A 717
ILE A 878
 None
 0.90A 4c8bB-4b9wA:
undetectable		 4c8bB-4b9wA:
21.11
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4cdg NANOBODY

(Lama glama) 		PF07686
(V-set) 		3 TYR C 101
MET C 100
ILE C  72
 None
 0.85A 4c8bB-4cdgC:
undetectable		 4c8bB-4cdgC:
17.37
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ckr EPITHELIAL DISCOIDIN
DOMAIN-CONTAINING
RECEPTOR 1

(Homo sapiens) 		PF07714
(Pkinase_Tyr) 		3 TYR A 703
MET A 704
ILE A 684
 DI1  A1000 (-4.0A)
None
DI1  A1000 ( 4.5A)
 0.61A 4c8bB-4ckrA:
25.5		 4c8bB-4ckrA:
26.40
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ckr EPITHELIAL DISCOIDIN
DOMAIN-CONTAINING
RECEPTOR 1

(Homo sapiens) 		PF07714
(Pkinase_Tyr) 		3 TYR A 703
MET A 704
ILE A 782
 DI1  A1000 (-4.0A)
None
DI1  A1000 (-4.5A)
 0.55A 4c8bB-4ckrA:
25.5		 4c8bB-4ckrA:
26.40
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4f0i HIGH AFFINITY NERVE
GROWTH FACTOR
RECEPTOR

(Homo sapiens) 		PF07714
(Pkinase_Tyr) 		3 TYR A 590
MET A 591
ILE A 571
 None
 0.68A 4c8bB-4f0iA:
26.6		 4c8bB-4f0iA:
28.17
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4f0i HIGH AFFINITY NERVE
GROWTH FACTOR
RECEPTOR

(Homo sapiens) 		PF07714
(Pkinase_Tyr) 		3 TYR A 590
MET A 591
ILE A 665
 None
 0.41A 4c8bB-4f0iA:
26.6		 4c8bB-4f0iA:
28.17
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4j1y COMPLEMENT C1S
SUBCOMPONENT

(Homo sapiens) 		PF00084
(Sushi)
PF00089
(Trypsin) 		3 TYR A 390
MET A 541
ILE A 465
 None
 0.91A 4c8bB-4j1yA:
undetectable		 4c8bB-4j1yA:
21.53
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4j3o OUTER MEMBRANE USHER
PROTEIN FIMD

(Escherichia
coli) 		PF00577
(Usher)
PF13953
(PapC_C)
PF13954
(PapC_N) 		3 TYR D  43
MET D  44
ILE D 115
 None
 0.75A 4c8bB-4j3oD:
undetectable		 4c8bB-4j3oD:
16.94
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4jrf PUTATIVE CELL
ADHESION PROTEIN

(Bacteroides
ovatus) 		PF15495
(Fimbrillin_C) 		3 TYR A 272
MET A 311
ILE A 445
 None
CA  A 601 ( 4.5A)
None
 0.76A 4c8bB-4jrfA:
undetectable		 4c8bB-4jrfA:
20.79
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4k90 EXTRACELLULAR
METALLOPROTEINASE
MEP

(Aspergillus
fumigatus) 		PF02128
(Peptidase_M36) 		3 TYR A 409
MET A 408
ILE A 428
 None
 0.74A 4c8bB-4k90A:
undetectable		 4c8bB-4k90A:
19.61
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4kcb ARABINAN
ENDO-1,5-ALPHA-L-ARA
BINOSIDASE

(uncultured
bacterium) 		PF04616
(Glyco_hydro_43) 		3 TYR A 110
MET A 109
ILE A  52
 None
 0.91A 4c8bB-4kcbA:
undetectable		 4c8bB-4kcbA:
20.68
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4kml NANOBODY

(Lama glama) 		PF07686
(V-set) 		3 TYR B  80
MET B  79
ILE B 104
 None
 0.88A 4c8bB-4kmlB:
undetectable		 4c8bB-4kmlB:
19.42
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4l68 LEUCINE-RICH REPEAT
PROTEIN KINASE-LIKE
PROTEIN

(Arabidopsis
thaliana) 		PF07714
(Pkinase_Tyr) 		3 TYR A 381
MET A 382
ILE A 445
 None
 0.48A 4c8bB-4l68A:
21.3		 4c8bB-4l68A:
27.90
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4mh1 SORBOSE
DEHYDROGENASE

(Ketogulonicigenium
vulgare) 		PF13360
(PQQ_2) 		3 TYR A  68
MET A  67
ILE A 519
 None
 0.92A 4c8bB-4mh1A:
undetectable		 4c8bB-4mh1A:
20.31
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4mio INOSITOL
2-DEHYDROGENASE/D-CH
IRO-INOSITOL
3-DEHYDROGENASE

(Lactobacillus
casei) 		PF01408
(GFO_IDH_MocA) 		3 TYR A 129
MET A 126
ILE A 275
 None
NAI  A 401 ( 3.7A)
None
 0.83A 4c8bB-4mioA:
undetectable		 4c8bB-4mioA:
21.21
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4p2k EPHRIN TYPE-A
RECEPTOR 2

(Homo sapiens) 		PF07714
(Pkinase_Tyr)
PF14575
(EphA2_TM) 		3 TYR A 694
MET A 695
ILE A 675
 None
 0.82A 4c8bB-4p2kA:
27.0		 4c8bB-4p2kA:
28.12
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4p2k EPHRIN TYPE-A
RECEPTOR 2

(Homo sapiens) 		PF07714
(Pkinase_Tyr)
PF14575
(EphA2_TM) 		3 TYR A 694
MET A 695
ILE A 745
 None
 0.88A 4c8bB-4p2kA:
27.0		 4c8bB-4p2kA:
28.12
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ptf DNA POLYMERASE
EPSILON CATALYTIC
SUBUNIT A

(Saccharomyces
cerevisiae) 		PF00136
(DNA_pol_B)
PF03104
(DNA_pol_B_exo1) 		3 TYR A 120
MET A  82
ILE A 500
 None
 0.88A 4c8bB-4ptfA:
2.4		 4c8bB-4ptfA:
15.30
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4qiw DNA-DIRECTED RNA
POLYMERASE, SUBUNIT
E'
DNA-DIRECTED RNA
POLYMERASE, SUBUNIT
F

(Thermococcus
kodakarensis) 		PF00575
(S1)
PF03874
(RNA_pol_Rpb4)
PF03876
(SHS2_Rpb7-N) 		3 TYR E   2
MET E   1
ILE F  77
 None
 0.57A 4c8bB-4qiwE:
undetectable		 4c8bB-4qiwE:
19.76
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4tqo METHANOL
DEHYDROGENASE
PROTEIN, LARGE
SUBUNIT

(Methylococcus
capsulatus) 		no annotation 3 TYR B  94
MET B  93
ILE B 552
 None
 0.85A 4c8bB-4tqoB:
undetectable		 4c8bB-4tqoB:
18.93
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4xjv S-ACYL FATTY ACID
SYNTHASE
THIOESTERASE, MEDIUM
CHAIN

(Homo sapiens) 		PF00975
(Thioesterase) 		3 TYR A 105
MET A 102
ILE A 179
 None
 0.87A 4c8bB-4xjvA:
undetectable		 4c8bB-4xjvA:
21.08
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4yzt CELLULOSE HYDROLASE

(Bacillus
licheniformis) 		PF00150
(Cellulase)
PF03442
(CBM_X2) 		3 TYR A 269
MET A 299
ILE A  70
 None
 0.82A 4c8bB-4yztA:
undetectable		 4c8bB-4yztA:
22.88
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5aw4 NA, K-ATPASE ALPHA
SUBUNIT

(Squalus
acanthias) 		PF00122
(E1-E2_ATPase)
PF00689
(Cation_ATPase_C)
PF00690
(Cation_ATPase_N)
PF13246
(Cation_ATPase) 		3 TYR A 981
MET A 980
ILE A 807
 None
 0.85A 4c8bB-5aw4A:
undetectable		 4c8bB-5aw4A:
16.20
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5aw4 NA, K-ATPASE ALPHA
SUBUNIT

(Squalus
acanthias) 		PF00122
(E1-E2_ATPase)
PF00689
(Cation_ATPase_C)
PF00690
(Cation_ATPase_N)
PF13246
(Cation_ATPase) 		3 TYR A 981
MET A 980
ILE A 926
 None
 0.90A 4c8bB-5aw4A:
undetectable		 4c8bB-5aw4A:
16.20
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5b4x LOW DENSITY
LIPOPROTEIN
RECEPTOR-RELATED
PROTEIN 8,
APOLIPOPROTEIN E
RECEPTOR, ISOFORM
CRA_E

(Homo sapiens) 		PF00057
(Ldl_recept_a)
PF00058
(Ldl_recept_b)
PF07645
(EGF_CA)
PF14670
(FXa_inhibition) 		3 TYR B 425
MET B 424
ILE B 381
 None
 0.66A 4c8bB-5b4xB:
undetectable		 4c8bB-5b4xB:
19.51
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5e24 SUPPRESSOR OF
HAIRLESS PROTEIN

(Drosophila
melanogaster) 		PF09270
(BTD)
PF09271
(LAG1-DNAbind) 		3 TYR E 363
MET E 364
ILE E 380
 None
EDO  E 612 (-4.9A)
None
 0.92A 4c8bB-5e24E:
undetectable		 4c8bB-5e24E:
21.10
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5g06 EXOSOME COMPLEX
COMPONENT SKI6

(Saccharomyces
cerevisiae) 		PF01138
(RNase_PH)
PF03725
(RNase_PH_C) 		3 TYR B  41
MET B  42
ILE B 140
 None
 0.76A 4c8bB-5g06B:
undetectable		 4c8bB-5g06B:
22.25
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5gqf LACTO-N-BIOSIDASE

(Bifidobacterium
longum) 		no annotation 3 TYR A 531
MET A 530
ILE A 592
 None
 0.83A 4c8bB-5gqfA:
undetectable		 4c8bB-5gqfA:
19.19
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5hx6 RECEPTOR-INTERACTING
SERINE/THREONINE-PRO
TEIN KINASE 1

(Homo sapiens) 		PF07714
(Pkinase_Tyr) 		3 TYR A  94
MET A  95
ILE A 144
 None
 0.80A 4c8bB-5hx6A:
23.2		 4c8bB-5hx6A:
32.67
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5hx6 RECEPTOR-INTERACTING
SERINE/THREONINE-PRO
TEIN KINASE 1

(Homo sapiens) 		PF07714
(Pkinase_Tyr) 		3 TYR A  94
MET A  95
ILE A 154
 None
None
65U  A 301 (-4.1A)
 0.32A 4c8bB-5hx6A:
23.2		 4c8bB-5hx6A:
32.67
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ls6 HISTONE-LYSINE
N-METHYLTRANSFERASE
EZH2,HISTONE-LYSINE
N-METHYLTRANSFERASE
EZH2,HISTONE-LYSINE
N-METHYLTRANSFERASE
EZH2

(Homo sapiens) 		PF00856
(SET)
PF11616
(EZH2_WD-Binding) 		3 TYR A 111
MET A 110
ILE A 626
 74D  A 809 (-3.8A)
None
None
 0.90A 4c8bB-5ls6A:
undetectable		 4c8bB-5ls6A:
17.37
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5oki DNA POLYMERASE
EPSILON CATALYTIC
SUBUNIT A

(Saccharomyces
cerevisiae) 		no annotation 3 TYR A 120
MET A  82
ILE A 500
 None
 0.90A 4c8bB-5okiA:
undetectable		 4c8bB-5okiA:
14.06
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5tpv WLARA,
TDP-FUCOSE-3,4-KETOI
SOMERASE

(Campylobacter
jejuni) 		PF05523
(FdtA) 		3 TYR A  98
MET A  97
ILE A  59
 None
 0.90A 4c8bB-5tpvA:
undetectable		 4c8bB-5tpvA:
18.81
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5w5j RECEPTOR-INTERACTING
SERINE/THREONINE-PRO
TEIN KINASE 2

(Homo sapiens) 		no annotation 3 TYR A  97
MET A  98
ILE A  78
 None
 0.66A 4c8bB-5w5jA:
35.6		 4c8bB-5w5jA:
92.99
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5w5j RECEPTOR-INTERACTING
SERINE/THREONINE-PRO
TEIN KINASE 2

(Homo sapiens) 		no annotation 3 TYR A  97
MET A  98
ILE A 152
 None
 0.78A 4c8bB-5w5jA:
35.6		 4c8bB-5w5jA:
92.99
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5w5j RECEPTOR-INTERACTING
SERINE/THREONINE-PRO
TEIN KINASE 2

(Homo sapiens) 		no annotation 3 TYR A  97
MET A  98
ILE A 162
 None
 0.17A 4c8bB-5w5jA:
35.6		 4c8bB-5w5jA:
92.99
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5wg6 HISTONE-LYSINE
N-METHYLTRANSFERASE
EZH2,POLYCOMB
PROTEIN SUZ12
(E.C.2.1.1.43)
CHIMERA

(Homo sapiens) 		no annotation 3 TYR A 111
MET A 110
ILE A 626
 None
A9G  A9009 ( 4.3A)
None
 0.92A 4c8bB-5wg6A:
undetectable		 4c8bB-5wg6A:
13.47
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5wnm RECEPTOR-INTERACTING
SERINE/THREONINE-PRO
TEIN KINASE 4

(Mus musculus) 		no annotation 3 TYR A  98
MET A  99
ILE A  81
 VX6  A 402 (-4.3A)
None
None
 0.59A 4c8bB-5wnmA:
31.0		 4c8bB-5wnmA:
12.73
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5wnm RECEPTOR-INTERACTING
SERINE/THREONINE-PRO
TEIN KINASE 4

(Mus musculus) 		no annotation 3 TYR A  98
MET A  99
ILE A 159
 VX6  A 402 (-4.3A)
None
None
 0.27A 4c8bB-5wnmA:
31.0		 4c8bB-5wnmA:
12.73
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5xog DNA-DIRECTED RNA
POLYMERASE SUBUNIT
BETA

(Komagataella
phaffii) 		PF00562
(RNA_pol_Rpb2_6)
PF04560
(RNA_pol_Rpb2_7)
PF04561
(RNA_pol_Rpb2_2)
PF04563
(RNA_pol_Rpb2_1)
PF04565
(RNA_pol_Rpb2_3)
PF04566
(RNA_pol_Rpb2_4)
PF04567
(RNA_pol_Rpb2_5) 		3 TYR B1073
MET B1072
ILE B 824
 None
 0.88A 4c8bB-5xogB:
undetectable		 4c8bB-5xogB:
14.27
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5y3r DNA-DEPENDENT
PROTEIN KINASE
CATALYTIC SUBUNIT

(Homo sapiens) 		PF00454
(PI3_PI4_kinase)
PF02259
(FAT)
PF02260
(FATC)
PF08163
(NUC194) 		3 TYR C 788
MET C 785
ILE C 778
 None
 0.77A 4c8bB-5y3rC:
undetectable		 4c8bB-5y3rC:
5.88
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5yh5 NICKEL ABC
TRANSPORTER
SUBSTRATE-BINDING
PROTEIN

(Staphylococcus
aureus) 		no annotation 3 TYR A 353
MET A 352
ILE A 472
 None
 0.88A 4c8bB-5yh5A:
undetectable		 4c8bB-5yh5A:
12.50
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6f3d INTERLEUKIN-1
RECEPTOR-ASSOCIATED
KINASE 4

(Homo sapiens) 		no annotation 3 TYR A 264
MET A 265
ILE A 317
 CJT  A 502 (-4.5A)
CJT  A 502 (-4.9A)
None
 0.85A 4c8bB-6f3dA:
25.0		 4c8bB-6f3dA:
12.28
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6f3d INTERLEUKIN-1
RECEPTOR-ASSOCIATED
KINASE 4

(Homo sapiens) 		no annotation 3 TYR A 264
MET A 265
ILE A 327
 CJT  A 502 (-4.5A)
CJT  A 502 (-4.9A)
None
 0.46A 4c8bB-6f3dA:
25.0		 4c8bB-6f3dA:
12.28
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6gun -

(-) 		no annotation 3 TYR A 219
MET A 218
ILE A 189
 None
 0.82A 4c8bB-6gunA:
undetectable		 4c8bB-6gunA:
undetectable