SIMILAR PATTERNS OF AMINO ACIDS FOR 4C8B_B_0LIB1000

List of similar pattern of amino acids derived from ASSAM search

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click link on the last column to view superposed patterns of amino acids in NGL viewer)
(Note that only 3-12 residue patterns can be used for ASSAM searches)
Filter list by:
Hit Macromolecule/
Organism		 Pfam Res. Interface HETATM RMSD Dali Z-score Seq. Identity (%) View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1h4l CELL DIVISION
PROTEIN KINASE 5

(Homo sapiens) 		PF00069
(Pkinase) 		7 ALA A  31
LYS A  33
GLU A  51
LEU A  55
ILE A  63
LEU A 133
ALA A 143
 None
 0.89A 4c8bB-1h4lA:
22.4		 4c8bB-1h4lA:
24.86
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1h4l CELL DIVISION
PROTEIN KINASE 5

(Homo sapiens) 		PF00069
(Pkinase) 		7 ALA A  31
LYS A  33
LEU A  55
ILE A  63
HIS A 124
LEU A 133
ALA A 143
 None
 0.71A 4c8bB-1h4lA:
22.4		 4c8bB-1h4lA:
24.86
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1luf MUSCLE-SPECIFIC
TYROSINE KINASE
RECEPTOR MUSK

(Rattus
norvegicus) 		PF07714
(Pkinase_Tyr) 		7 ALA A 606
LYS A 608
ILE A 637
HIS A 722
LEU A 731
ALA A 741
ASP A 742
 None
 0.68A 4c8bB-1lufA:
27.3		 4c8bB-1lufA:
27.42
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1opk PROTO-ONCOGENE
TYROSINE-PROTEIN
KINASE ABL1

(Mus musculus) 		PF00017
(SH2)
PF00018
(SH3_1)
PF07714
(Pkinase_Tyr) 		7 ALA A 288
LYS A 290
GLU A 305
THR A 334
HIS A 380
LEU A 389
ALA A 399
 P16  A   2 (-3.4A)
P16  A   2 (-4.5A)
P16  A   2 (-4.2A)
P16  A   2 (-3.7A)
None
P16  A   2 (-4.4A)
P16  A   2 (-3.5A)
 0.47A 4c8bB-1opkA:
25.6		 4c8bB-1opkA:
20.68
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1py5 TGF-BETA RECEPTOR
TYPE I

(Homo sapiens) 		PF00069
(Pkinase)
PF08515
(TGF_beta_GS) 		8 ALA A 230
LYS A 232
GLU A 245
ILE A 259
LEU A 260
HIS A 331
LEU A 340
ALA A 350
 PY1  A 700 (-3.5A)
PY1  A 700 (-3.9A)
PY1  A 700 ( 4.9A)
None
PY1  A 700 (-4.2A)
None
PY1  A 700 (-4.4A)
PY1  A 700 ( 4.2A)
 0.66A 4c8bB-1py5A:
18.7		 4c8bB-1py5A:
26.18
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1q8y SR PROTEIN KINASE

(Saccharomyces
cerevisiae) 		PF00069
(Pkinase) 		8 ALA A 185
LEU A 206
ILE A 225
LEU A 226
HIS A 292
LEU A 301
ALA A 549
ASP A 550
 ADP  A 810 (-3.3A)
None
None
ADP  A 810 (-4.4A)
None
ADP  A 810 (-4.7A)
None
ADP  A 810 ( 3.0A)
 0.98A 4c8bB-1q8yA:
20.9		 4c8bB-1q8yA:
23.76
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1q8y SR PROTEIN KINASE

(Saccharomyces
cerevisiae) 		PF00069
(Pkinase) 		9 ALA A 185
LYS A 187
GLU A 202
LEU A 206
ILE A 225
LEU A 226
HIS A 292
LEU A 301
ALA A 549
 ADP  A 810 (-3.3A)
ADP  A 810 (-3.1A)
None
None
None
ADP  A 810 (-4.4A)
None
ADP  A 810 (-4.7A)
None
 0.76A 4c8bB-1q8yA:
20.9		 4c8bB-1q8yA:
23.76
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1rjb FL CYTOKINE RECEPTOR

(Homo sapiens) 		PF07714
(Pkinase_Tyr) 		7 ALA A 642
LYS A 644
GLU A 661
ILE A 674
HIS A 809
LEU A 818
ASP A 829
 None
 0.85A 4c8bB-1rjbA:
25.3		 4c8bB-1rjbA:
25.85
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1t46 HOMO SAPIENS V-KIT
HARDY-ZUCKERMAN 4
FELINE SARCOMA VIRAL
ONCOGENE HOMOLOG

(Homo sapiens) 		PF07714
(Pkinase_Tyr) 		7 ALA A 621
LYS A 623
GLU A 640
HIS A 790
LEU A 799
ASP A 810
PHE A 811
 STI  A   3 (-3.5A)
STI  A   3 (-3.7A)
STI  A   3 (-3.6A)
STI  A   3 (-4.5A)
STI  A   3 (-4.4A)
STI  A   3 (-3.9A)
STI  A   3 (-3.6A)
 0.83A 4c8bB-1t46A:
26.8		 4c8bB-1t46A:
26.68
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1t46 HOMO SAPIENS V-KIT
HARDY-ZUCKERMAN 4
FELINE SARCOMA VIRAL
ONCOGENE HOMOLOG

(Homo sapiens) 		PF07714
(Pkinase_Tyr) 		9 ALA A 621
LYS A 623
GLU A 640
LEU A 644
ILE A 653
THR A 670
HIS A 790
LEU A 799
ASP A 810
 STI  A   3 (-3.5A)
STI  A   3 (-3.7A)
STI  A   3 (-3.6A)
STI  A   3 (-4.4A)
None
STI  A   3 (-3.2A)
STI  A   3 (-4.5A)
STI  A   3 (-4.4A)
STI  A   3 (-3.9A)
 0.59A 4c8bB-1t46A:
26.8		 4c8bB-1t46A:
26.68
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2buj SERINE/THREONINE-PRO
TEIN KINASE 16

(Homo sapiens) 		PF00069
(Pkinase) 		8 ALA A  47
LYS A  49
GLU A  65
ILE A  77
LEU A  78
HIS A 146
LEU A 155
ASP A 166
 STU  A1301 (-3.6A)
STU  A1301 ( 4.0A)
None
None
None
None
STU  A1301 ( 4.8A)
None
 0.98A 4c8bB-2bujA:
24.2		 4c8bB-2bujA:
26.54
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2jgz CELL DIVISION
PROTEIN KINASE 2

(Homo sapiens) 		PF00069
(Pkinase) 		7 ALA A  31
GLU A  51
LEU A  55
ILE A  63
HIS A 125
LEU A 134
ALA A 144
 None
 0.77A 4c8bB-2jgzA:
15.8		 4c8bB-2jgzA:
25.66
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2jkm FOCAL ADHESION
KINASE 1

(Gallus gallus) 		PF07714
(Pkinase_Tyr) 		7 ALA A 452
LYS A 454
GLU A 471
ILE A 483
HIS A 544
LEU A 553
ASP A 564
 BII  A1687 (-3.5A)
BII  A1687 (-2.9A)
None
None
None
BII  A1687 (-4.2A)
None
 0.92A 4c8bB-2jkmA:
27.2		 4c8bB-2jkmA:
26.67
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2og8 PROTO-ONCOGENE
TYROSINE-PROTEIN
KINASE LCK

(Homo sapiens) 		PF07714
(Pkinase_Tyr) 		9 ALA A 271
LYS A 273
GLU A 288
THR A 316
HIS A 362
LEU A 371
ALA A 381
ASP A 382
PHE A 383
 1N8  A 501 ( 3.4A)
1N8  A 501 ( 3.4A)
1N8  A 501 ( 3.6A)
1N8  A 501 ( 3.3A)
None
1N8  A 501 ( 4.3A)
1N8  A 501 ( 3.3A)
1N8  A 501 ( 3.3A)
1N8  A 501 ( 4.3A)
 0.65A 4c8bB-2og8A:
27.1		 4c8bB-2og8A:
26.61
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2ogv MACROPHAGE
COLONY-STIMULATING
FACTOR 1 RECEPTOR
PRECURSOR

(Homo sapiens) 		PF07714
(Pkinase_Tyr) 		7 ALA A 614
GLU A 633
ILE A 646
THR A 663
HIS A 776
LEU A 785
ASP A 796
 None
 0.86A 4c8bB-2ogvA:
25.2		 4c8bB-2ogvA:
26.14
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2p4i ANGIOPOIETIN-1
RECEPTOR

(Homo sapiens) 		PF07714
(Pkinase_Tyr) 		7 ALA A 853
ILE A 885
HIS A 962
LEU A 971
ALA A 981
ASP A 982
PHE A 983
 MR9  A 301 (-3.5A)
MR9  A 301 ( 4.5A)
MR9  A 301 (-4.5A)
MR9  A 301 (-4.5A)
MR9  A 301 (-3.2A)
MR9  A 301 (-4.2A)
MR9  A 301 (-4.4A)
 0.77A 4c8bB-2p4iA:
11.4		 4c8bB-2p4iA:
25.75
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2phk PHOSPHORYLASE KINASE

(Oryctolagus
cuniculus) 		PF00069
(Pkinase) 		7 ALA A  46
LYS A  48
GLU A  73
LEU A  77
ILE A  86
HIS A 147
LEU A 156
 ATP  A 381 (-3.5A)
ATP  A 381 (-3.2A)
None
None
None
None
ATP  A 381 ( 4.8A)
 0.80A 4c8bB-2phkA:
23.9		 4c8bB-2phkA:
26.88
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2qlu ACTIVIN RECEPTOR
TYPE IIB

(Homo sapiens) 		PF00069
(Pkinase) 		7 ALA A 215
LYS A 217
LEU A 245
THR A 265
HIS A 319
LEU A 328
ALA A 338
 ADE  A 488 (-3.2A)
None
ADE  A 488 ( 4.5A)
ADE  A 488 (-4.3A)
None
ADE  A 488 (-4.4A)
None
 0.52A 4c8bB-2qluA:
24.9		 4c8bB-2qluA:
27.91
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2qr7 RIBOSOMAL PROTEIN S6
KINASE ALPHA-3

(Mus musculus) 		PF00069
(Pkinase) 		7 ALA A 449
LYS A 451
GLU A 463
LEU A 467
ILE A 476
THR A 493
HIS A 537
 None
 0.59A 4c8bB-2qr7A:
20.3		 4c8bB-2qr7A:
25.71
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2vd5 DMPK PROTEIN

(Homo sapiens) 		PF00069
(Pkinase) 		7 ALA A  98
LYS A 100
GLU A 119
LEU A 123
ILE A 131
LEU A 202
ALA A 212
 BI8  A1417 ( 3.8A)
BI8  A1417 (-4.2A)
BI8  A1417 ( 4.9A)
None
None
BI8  A1417 (-4.8A)
BI8  A1417 ( 4.1A)
 0.79A 4c8bB-2vd5A:
21.4		 4c8bB-2vd5A:
23.90
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2vd5 DMPK PROTEIN

(Homo sapiens) 		PF00069
(Pkinase) 		7 ALA A  98
LYS A 100
LEU A 123
ILE A 131
HIS A 193
LEU A 202
ALA A 212
 BI8  A1417 ( 3.8A)
BI8  A1417 (-4.2A)
None
None
None
BI8  A1417 (-4.8A)
BI8  A1417 ( 4.1A)
 0.68A 4c8bB-2vd5A:
21.4		 4c8bB-2vd5A:
23.90
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2xik SERINE/THREONINE
PROTEIN KINASE 25

(Homo sapiens) 		PF00069
(Pkinase) 		7 ALA A  47
GLU A  66
LEU A  70
ILE A  78
HIS A 138
LEU A 147
ALA A 157
 J60  A1294 (-3.3A)
None
None
None
None
J60  A1294 (-4.8A)
J60  A1294 ( 4.2A)
 0.60A 4c8bB-2xikA:
17.9		 4c8bB-2xikA:
26.79
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2xik SERINE/THREONINE
PROTEIN KINASE 25

(Homo sapiens) 		PF00069
(Pkinase) 		7 ALA A  47
LYS A  49
GLU A  66
LEU A  70
HIS A 138
LEU A 147
ALA A 157
 J60  A1294 (-3.3A)
None
None
None
None
J60  A1294 (-4.8A)
J60  A1294 ( 4.2A)
 0.81A 4c8bB-2xikA:
17.9		 4c8bB-2xikA:
26.79
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2xyu EPHRIN TYPE-A
RECEPTOR 4,

(Mus musculus) 		PF07714
(Pkinase_Tyr) 		7 ALA A 651
LYS A 653
ILE A 682
THR A 699
HIS A 744
LEU A 753
ASP A 764
 Q9G  A1898 (-3.2A)
Q9G  A1898 (-4.8A)
None
Q9G  A1898 (-3.5A)
None
Q9G  A1898 (-4.3A)
None
 0.79A 4c8bB-2xyuA:
27.8		 4c8bB-2xyuA:
28.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3c4f BASIC FIBROBLAST
GROWTH FACTOR
RECEPTOR 1

(Homo sapiens) 		PF07714
(Pkinase_Tyr) 		7 ALA A 512
GLU A 531
ILE A 544
HIS A 621
LEU A 630
ALA A 640
PHE A 489
 C4F  A   1 (-3.3A)
None
None
None
C4F  A   1 (-4.6A)
C4F  A   1 (-3.6A)
C4F  A   1 (-3.7A)
 0.85A 4c8bB-3c4fA:
26.5		 4c8bB-3c4fA:
26.35
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3dko EPHRIN TYPE-A
RECEPTOR 7

(Homo sapiens) 		PF07714
(Pkinase_Tyr)
PF14575
(EphA2_TM) 		7 ALA A 663
LYS A 665
GLU A 682
HIS A 756
LEU A 765
ASP A 776
PHE A 777
 IHZ  A1001 (-3.3A)
IHZ  A1001 ( 4.5A)
IHZ  A1001 (-3.8A)
IHZ  A1001 ( 4.9A)
IHZ  A1001 (-4.6A)
IHZ  A1001 (-4.8A)
IHZ  A1001 (-4.7A)
 0.83A 4c8bB-3dkoA:
27.0		 4c8bB-3dkoA:
26.16
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3e7o MITOGEN-ACTIVATED
PROTEIN KINASE 9

(Homo sapiens) 		PF00069
(Pkinase) 		7 ALA A  53
LYS A  55
GLU A  73
LEU A  77
ILE A  85
HIS A 149
ASP A 169
 35F  A   1 (-3.6A)
35F  A   1 ( 4.6A)
None
None
None
None
None
 0.96A 4c8bB-3e7oA:
21.1		 4c8bB-3e7oA:
23.51
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3gp0 MITOGEN-ACTIVATED
PROTEIN KINASE 11

(Homo sapiens) 		PF00069
(Pkinase) 		7 ALA A  51
LYS A  53
GLU A  71
LEU A  75
THR A 106
HIS A 148
ASP A 168
 NIL  A   1 (-3.7A)
None
NIL  A   1 (-3.7A)
NIL  A   1 ( 4.8A)
NIL  A   1 (-3.3A)
NIL  A   1 (-4.3A)
NIL  A   1 (-4.6A)
 0.71A 4c8bB-3gp0A:
22.0		 4c8bB-3gp0A:
25.46
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3hng VASCULAR ENDOTHELIAL
GROWTH FACTOR
RECEPTOR 1

(Homo sapiens) 		PF07714
(Pkinase_Tyr) 		7 ALA A 859
LYS A 861
GLU A 878
HIS A1020
LEU A1029
ASP A1040
PHE A1041
 8ST  A2001 ( 3.8A)
8ST  A2001 (-4.0A)
8ST  A2001 (-3.7A)
8ST  A2001 ( 4.8A)
None
None
8ST  A2001 ( 3.7A)
 0.83A 4c8bB-3hngA:
25.9		 4c8bB-3hngA:
24.57
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3hng VASCULAR ENDOTHELIAL
GROWTH FACTOR
RECEPTOR 1

(Homo sapiens) 		PF07714
(Pkinase_Tyr) 		7 ALA A 859
LYS A 861
GLU A 878
LEU A 882
HIS A1020
LEU A1029
ASP A1040
 8ST  A2001 ( 3.8A)
8ST  A2001 (-4.0A)
8ST  A2001 (-3.7A)
None
8ST  A2001 ( 4.8A)
None
None
 0.77A 4c8bB-3hngA:
25.9		 4c8bB-3hngA:
24.57
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3iec SERINE/THREONINE-PRO
TEIN KINASE MARK2

(Homo sapiens) 		PF00069
(Pkinase)
PF00627
(UBA) 		7 ALA A  80
LYS A  82
ILE A 112
HIS A 173
LEU A 182
ALA A 192
ASP A 193
 None
 0.83A 4c8bB-3iecA:
22.6		 4c8bB-3iecA:
26.04
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3kul EPHRIN TYPE-A
RECEPTOR 8

(Homo sapiens) 		PF07714
(Pkinase_Tyr)
PF14575
(EphA2_TM) 		7 ALA A 665
LYS A 667
GLU A 684
ILE A 696
THR A 713
HIS A 758
LEU A 767
 None
 0.56A 4c8bB-3kulA:
27.2		 4c8bB-3kulA:
31.11
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3llt SERINE/THREONINE
KINASE-1, PFLAMMER

(Plasmodium
falciparum) 		PF00069
(Pkinase) 		8 ALA A 579
LYS A 581
GLU A 596
LEU A 600
ILE A 613
HIS A 675
LEU A 684
ASP A 720
 ANP  A 877 ( 3.7A)
ANP  A 877 (-2.7A)
ANP  A 877 ( 4.4A)
None
None
None
None
ANP  A 877 (-2.9A)
 1.06A 4c8bB-3lltA:
20.8		 4c8bB-3lltA:
28.24
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3mdy BONE MORPHOGENETIC
PROTEIN RECEPTOR
TYPE-1B

(Homo sapiens) 		PF07714
(Pkinase_Tyr)
PF08515
(TGF_beta_GS) 		8 ALA A 229
LYS A 231
GLU A 244
ILE A 258
LEU A 259
THR A 279
LEU A 339
ALA A 349
 LDN  A   1 (-3.6A)
None
None
None
None
LDN  A   1 (-3.8A)
LDN  A   1 (-4.5A)
LDN  A   1 ( 3.8A)
 0.59A 4c8bB-3mdyA:
25.1		 4c8bB-3mdyA:
27.39
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3mdy BONE MORPHOGENETIC
PROTEIN RECEPTOR
TYPE-1B

(Homo sapiens) 		PF07714
(Pkinase_Tyr)
PF08515
(TGF_beta_GS) 		8 ALA A 229
LYS A 231
ILE A 258
LEU A 259
THR A 279
HIS A 330
LEU A 339
ALA A 349
 LDN  A   1 (-3.6A)
None
None
None
LDN  A   1 (-3.8A)
None
LDN  A   1 (-4.5A)
LDN  A   1 ( 3.8A)
 0.54A 4c8bB-3mdyA:
25.1		 4c8bB-3mdyA:
27.39
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3mi9 CELL DIVISION
PROTEIN KINASE 9

(Homo sapiens) 		PF00069
(Pkinase) 		7 ALA A  46
LYS A  48
GLU A  66
LEU A  70
HIS A 147
LEU A 156
ALA A 166
 None
 0.76A 4c8bB-3mi9A:
16.5		 4c8bB-3mi9A:
24.37
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3my0 SERINE/THREONINE-PRO
TEIN KINASE RECEPTOR
R3

(Homo sapiens) 		PF07714
(Pkinase_Tyr) 		8 ALA A 227
LYS A 229
ILE A 256
LEU A 257
THR A 277
HIS A 328
LEU A 337
ALA A 347
 LDN  A 600 (-3.2A)
LDN  A 600 (-4.0A)
None
None
LDN  A 600 (-4.0A)
None
LDN  A 600 (-4.6A)
LDN  A 600 ( 3.8A)
 0.73A 4c8bB-3my0A:
24.0		 4c8bB-3my0A:
27.04
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3my0 SERINE/THREONINE-PRO
TEIN KINASE RECEPTOR
R3

(Homo sapiens) 		PF07714
(Pkinase_Tyr) 		7 ILE A 256
LEU A 257
THR A 277
HIS A 328
LEU A 337
ALA A 347
ASP A 348
 None
None
LDN  A 600 (-4.0A)
None
LDN  A 600 (-4.6A)
LDN  A 600 ( 3.8A)
None
 0.81A 4c8bB-3my0A:
24.0		 4c8bB-3my0A:
27.04
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3n9x PHOSPHOTRANSFERASE

(Plasmodium
berghei) 		PF00069
(Pkinase) 		7 ALA A  55
LYS A  57
GLU A  75
LEU A  79
ILE A  87
HIS A 152
LEU A 161
 GOL  A 434 ( 4.1A)
GOL  A 433 (-3.2A)
GOL  A 433 ( 4.8A)
None
None
None
GOL  A 434 (-4.2A)
 0.80A 4c8bB-3n9xA:
12.1		 4c8bB-3n9xA:
28.04
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3nie MAP2 KINASE

(Plasmodium
falciparum) 		PF00069
(Pkinase) 		7 ALA A  57
LYS A  59
GLU A  77
LEU A  81
ILE A  89
HIS A 154
LEU A 163
 ANP  A 430 (-3.5A)
ANP  A 430 (-2.5A)
ANP  A 430 ( 4.4A)
None
None
None
ANP  A 430 (-4.4A)
 0.82A 4c8bB-3nieA:
20.9		 4c8bB-3nieA:
27.78
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3niz RHODANESE FAMILY
PROTEIN

(Cryptosporidium
parvum) 		PF00069
(Pkinase) 		7 ALA A  49
LEU A  73
ILE A  81
HIS A 142
LEU A 151
ALA A 161
ASP A 162
 ADP  A 314 (-3.5A)
None
None
None
ADP  A 314 (-4.6A)
None
MG  A 312 ( 3.3A)
 0.98A 4c8bB-3nizA:
23.9		 4c8bB-3nizA:
28.82
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3niz RHODANESE FAMILY
PROTEIN

(Cryptosporidium
parvum) 		PF00069
(Pkinase) 		7 ALA A  49
LYS A  51
GLU A  69
LEU A  73
ILE A  81
LEU A 151
ALA A 161
 ADP  A 314 (-3.5A)
ADP  A 314 (-2.8A)
None
None
None
ADP  A 314 (-4.6A)
None
 0.78A 4c8bB-3nizA:
23.9		 4c8bB-3nizA:
28.82
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3niz RHODANESE FAMILY
PROTEIN

(Cryptosporidium
parvum) 		PF00069
(Pkinase) 		7 ALA A  49
LYS A  51
LEU A  73
ILE A  81
HIS A 142
LEU A 151
ALA A 161
 ADP  A 314 (-3.5A)
ADP  A 314 (-2.8A)
None
None
None
ADP  A 314 (-4.6A)
None
 0.66A 4c8bB-3nizA:
23.9		 4c8bB-3nizA:
28.82
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3oz6 MITOGEN-ACTIVATED
PROTEIN KINASE 1,
SERINE/THREONINE
PROTEIN KINASE

(Cryptosporidium
parvum) 		PF00069
(Pkinase) 		7 ALA A  38
GLU A  58
LEU A  62
ILE A  71
HIS A 132
LEU A 141
ALA A 151
 None
 0.81A 4c8bB-3oz6A:
20.6		 4c8bB-3oz6A:
22.80
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3oz6 MITOGEN-ACTIVATED
PROTEIN KINASE 1,
SERINE/THREONINE
PROTEIN KINASE

(Cryptosporidium
parvum) 		PF00069
(Pkinase) 		7 ALA A  38
LYS A  40
LEU A  62
ILE A  71
HIS A 132
LEU A 141
ALA A 151
 None
 0.87A 4c8bB-3oz6A:
20.6		 4c8bB-3oz6A:
22.80
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3ppz SERINE/THREONINE-PRO
TEIN KINASE CTR1

(Arabidopsis
thaliana) 		PF07714
(Pkinase_Tyr) 		7 ALA A 576
LYS A 578
GLU A 596
ILE A 608
THR A 625
HIS A 674
LEU A 683
 STU  A   1 (-3.3A)
STU  A   1 (-3.5A)
None
None
STU  A   1 (-4.1A)
None
STU  A   1 (-4.3A)
 0.54A 4c8bB-3ppzA:
28.3		 4c8bB-3ppzA:
36.69
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3q4t ACTIVIN RECEPTOR
TYPE-2A

(Homo sapiens) 		PF00069
(Pkinase) 		7 ALA A 217
ILE A 246
LEU A 247
THR A 267
HIS A 320
LEU A 329
ALA A 339
 TAK  A   2 (-3.5A)
None
None
TAK  A   2 (-3.5A)
None
TAK  A   2 (-4.6A)
TAK  A   2 ( 4.2A)
 0.52A 4c8bB-3q4tA:
24.6		 4c8bB-3q4tA:
32.61
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3q5i PROTEIN KINASE

(Plasmodium
berghei) 		PF00069
(Pkinase)
PF13499
(EF-hand_7) 		7 ALA A  84
LYS A  86
GLU A 115
ILE A 127
THR A 144
HIS A 188
LEU A 197
 ANP  A1634 (-3.6A)
ANP  A1634 (-3.1A)
None
None
ANP  A1634 (-4.6A)
None
ANP  A1634 (-4.4A)
 0.79A 4c8bB-3q5iA:
21.3		 4c8bB-3q5iA:
24.85
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3q5i PROTEIN KINASE

(Plasmodium
berghei) 		PF00069
(Pkinase)
PF13499
(EF-hand_7) 		7 ALA A  84
LYS A  86
GLU A 115
LEU A 119
THR A 144
HIS A 188
LEU A 197
 ANP  A1634 (-3.6A)
ANP  A1634 (-3.1A)
None
None
ANP  A1634 (-4.6A)
None
ANP  A1634 (-4.4A)
 0.92A 4c8bB-3q5iA:
21.3		 4c8bB-3q5iA:
24.85
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3qfv CDC42BPB PROTEIN

(Homo sapiens) 		PF00069
(Pkinase) 		7 ALA A 103
LYS A 105
GLU A 124
LEU A 128
ILE A 136
LEU A 207
ALA A 217
 NM7  A 416 ( 3.7A)
EDO  A 417 (-3.5A)
EDO  A 417 (-4.0A)
None
None
NM7  A 416 ( 4.2A)
NM7  A 416 ( 4.5A)
 0.73A 4c8bB-3qfvA:
16.6		 4c8bB-3qfvA:
23.72
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3qfv CDC42BPB PROTEIN

(Homo sapiens) 		PF00069
(Pkinase) 		7 ALA A 103
LYS A 105
LEU A 128
ILE A 136
HIS A 198
LEU A 207
ALA A 217
 NM7  A 416 ( 3.7A)
EDO  A 417 (-3.5A)
None
None
None
NM7  A 416 ( 4.2A)
NM7  A 416 ( 4.5A)
 0.66A 4c8bB-3qfvA:
16.6		 4c8bB-3qfvA:
23.72
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3s95 LIM DOMAIN KINASE 1

(Homo sapiens) 		PF07714
(Pkinase_Tyr) 		7 LYS A 368
GLU A 384
LEU A 397
THR A 413
HIS A 458
LEU A 467
ALA A 477
 STU  A   1 (-3.1A)
STU  A   1 (-3.7A)
STU  A   1 (-4.6A)
STU  A   1 (-3.9A)
None
STU  A   1 (-4.6A)
STU  A   1 ( 4.1A)
 0.79A 4c8bB-3s95A:
25.2		 4c8bB-3s95A:
23.81
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3tt0 BASIC FIBROBLAST
GROWTH FACTOR
RECEPTOR 1

(Homo sapiens) 		PF07714
(Pkinase_Tyr) 		7 ALA A 512
LYS A 514
GLU A 531
ILE A 544
HIS A 621
LEU A 630
ALA A 640
 07J  A   1 (-3.5A)
07J  A   1 (-4.5A)
07J  A   1 (-3.8A)
None
None
07J  A   1 ( 4.4A)
07J  A   1 (-3.2A)
 0.62A 4c8bB-3tt0A:
26.5		 4c8bB-3tt0A:
27.07
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3v5q NT-3 GROWTH FACTOR
RECEPTOR

(Homo sapiens) 		PF07714
(Pkinase_Tyr) 		7 ALA A 570
GLU A 588
LEU A 592
ILE A 600
HIS A 677
LEU A 686
ASP A 697
 0F4  A 902 (-3.2A)
0F4  A 902 (-3.6A)
0F4  A 902 (-4.7A)
0F4  A 902 (-4.1A)
0F4  A 902 (-4.1A)
0F4  A 902 (-4.5A)
None
 0.86A 4c8bB-3v5qA:
26.7		 4c8bB-3v5qA:
29.30
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4agu CYCLIN-DEPENDENT
KINASE-LIKE 1

(Homo sapiens) 		PF00069
(Pkinase) 		7 ALA A  31
LYS A  33
GLU A  51
LEU A  55
HIS A 124
LEU A 133
ASP A 144
 D15  A 500 (-3.4A)
D15  A 500 ( 4.1A)
None
None
None
D15  A 500 (-4.5A)
D15  A 500 (-3.7A)
 0.92A 4c8bB-4aguA:
24.2		 4c8bB-4aguA:
23.29
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4aw2 SERINE/THREONINE-PRO
TEIN KINASE MRCK
ALPHA

(Rattus
norvegicus) 		PF00069
(Pkinase)
PF00433
(Pkinase_C) 		8 ALA A 104
LYS A 106
GLU A 125
LEU A 129
ILE A 137
HIS A 199
LEU A 208
ALA A 218
 EDO  A1420 (-3.4A)
EDO  A1419 (-3.3A)
EDO  A1419 (-3.0A)
None
None
None
EDO  A1420 ( 4.8A)
None
 0.71A 4c8bB-4aw2A:
21.1		 4c8bB-4aw2A:
24.55
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4b99 MITOGEN-ACTIVATED
PROTEIN KINASE 7

(Homo sapiens) 		PF00069
(Pkinase) 		7 ALA A  82
LYS A  84
LEU A 106
ILE A 114
HIS A 180
LEU A 189
ASP A 200
 R4L  A1394 ( 3.7A)
None
None
None
None
R4L  A1394 (-4.5A)
None
 0.88A 4c8bB-4b99A:
22.3		 4c8bB-4b99A:
24.14
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4bc6 SERINE/THREONINE-PRO
TEIN KINASE 10

(Homo sapiens) 		PF00069
(Pkinase) 		7 ALA A  63
GLU A  81
LEU A  85
ILE A  93
HIS A 155
LEU A 164
ALA A 174
 XZN  A1317 (-3.5A)
XZN  A1317 (-3.9A)
None
None
None
XZN  A1317 (-4.7A)
XZN  A1317 ( 4.3A)
 0.69A 4c8bB-4bc6A:
23.4		 4c8bB-4bc6A:
27.03
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4bgq CYCLIN-DEPENDENT
KINASE-LIKE 5

(Homo sapiens) 		PF00069
(Pkinase) 		7 ALA A  40
LYS A  42
LEU A  64
ILE A  72
HIS A 133
LEU A 142
ASP A 153
 38R  A1000 (-3.4A)
38R  A1000 (-3.4A)
None
None
None
38R  A1000 ( 4.5A)
38R  A1000 ( 4.2A)
 1.06A 4c8bB-4bgqA:
22.4		 4c8bB-4bgqA:
27.08
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4c02 ACTIVIN RECEPTOR
TYPE-1

(Homo sapiens) 		PF00069
(Pkinase)
PF08515
(TGF_beta_GS) 		8 ALA A 233
LYS A 235
ILE A 262
LEU A 263
THR A 283
HIS A 334
LEU A 343
ALA A 353
 TAK  A1507 (-3.3A)
TAK  A1507 ( 4.5A)
None
FLC  A1503 ( 4.5A)
TAK  A1507 (-3.6A)
None
TAK  A1507 (-4.7A)
TAK  A1507 ( 4.2A)
 0.69A 4c8bB-4c02A:
24.2		 4c8bB-4c02A:
27.91
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4cfh 5'-AMP-ACTIVATED
PROTEIN KINASE
CATALYTIC SUBUNIT
ALPHA-1

(Rattus
norvegicus) 		PF00069
(Pkinase)
PF16579
(AdenylateSensor) 		7 ALA A  43
LYS A  45
GLU A  64
LEU A  68
ILE A  76
LEU A 146
ALA A 156
 STU  A1550 (-3.1A)
STU  A1550 (-3.6A)
None
None
None
STU  A1550 (-4.3A)
STU  A1550 ( 3.8A)
 0.75A 4c8bB-4cfhA:
23.5		 4c8bB-4cfhA:
26.46
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4cfh 5'-AMP-ACTIVATED
PROTEIN KINASE
CATALYTIC SUBUNIT
ALPHA-1

(Rattus
norvegicus) 		PF00069
(Pkinase)
PF16579
(AdenylateSensor) 		7 ALA A  43
LYS A  45
LEU A  68
ILE A  76
HIS A 137
LEU A 146
ALA A 156
 STU  A1550 (-3.1A)
STU  A1550 (-3.6A)
None
None
None
STU  A1550 (-4.3A)
STU  A1550 ( 3.8A)
 0.76A 4c8bB-4cfhA:
23.5		 4c8bB-4cfhA:
26.46
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ckr EPITHELIAL DISCOIDIN
DOMAIN-CONTAINING
RECEPTOR 1

(Homo sapiens) 		PF07714
(Pkinase_Tyr) 		9 ALA A 653
GLU A 672
ILE A 684
THR A 701
HIS A 764
LEU A 773
ALA A 783
ASP A 784
PHE A 785
 DI1  A1000 (-3.6A)
DI1  A1000 (-3.8A)
DI1  A1000 ( 4.5A)
DI1  A1000 (-3.6A)
DI1  A1000 (-3.8A)
DI1  A1000 (-4.5A)
DI1  A1000 (-3.7A)
DI1  A1000 (-4.1A)
DI1  A1000 (-4.5A)
 0.67A 4c8bB-4ckrA:
25.5		 4c8bB-4ckrA:
26.40
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ckr EPITHELIAL DISCOIDIN
DOMAIN-CONTAINING
RECEPTOR 1

(Homo sapiens) 		PF07714
(Pkinase_Tyr) 		9 ALA A 653
LYS A 655
GLU A 672
ILE A 684
THR A 701
HIS A 764
LEU A 773
ALA A 783
ASP A 784
 DI1  A1000 (-3.6A)
DI1  A1000 (-3.9A)
DI1  A1000 (-3.8A)
DI1  A1000 ( 4.5A)
DI1  A1000 (-3.6A)
DI1  A1000 (-3.8A)
DI1  A1000 (-4.5A)
DI1  A1000 (-3.7A)
DI1  A1000 (-4.1A)
 0.49A 4c8bB-4ckrA:
25.5		 4c8bB-4ckrA:
26.40
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4hvi TYROSINE-PROTEIN
KINASE JAK3

(Homo sapiens) 		PF07714
(Pkinase_Tyr) 		8 ALA A 853
LYS A 855
GLU A 871
LEU A 875
ILE A 883
HIS A 947
LEU A 956
ALA A 966
 19S  A1201 (-3.3A)
19S  A1201 (-3.5A)
None
None
None
None
19S  A1201 (-4.5A)
19S  A1201 ( 4.1A)
 0.53A 4c8bB-4hviA:
18.7		 4c8bB-4hviA:
29.86
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4hvi TYROSINE-PROTEIN
KINASE JAK3

(Homo sapiens) 		PF07714
(Pkinase_Tyr) 		8 LYS A 855
GLU A 871
LEU A 875
ILE A 883
HIS A 947
LEU A 956
ALA A 966
ASP A 967
 19S  A1201 (-3.5A)
None
None
None
None
19S  A1201 (-4.5A)
19S  A1201 ( 4.1A)
19S  A1201 ( 4.1A)
 0.97A 4c8bB-4hviA:
18.7		 4c8bB-4hviA:
29.86
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4k33 FIBROBLAST GROWTH
FACTOR RECEPTOR 3

(Homo sapiens) 		PF07714
(Pkinase_Tyr) 		7 ALA A 506
LYS A 508
GLU A 525
ILE A 538
HIS A 615
LEU A 624
ALA A 634
 ACP  A 801 (-3.3A)
ACP  A 801 (-2.7A)
ACP  A 801 ( 4.8A)
None
None
ACP  A 801 (-4.4A)
None
 0.83A 4c8bB-4k33A:
26.2		 4c8bB-4k33A:
30.92
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4l52 MITOGEN-ACTIVATED
PROTEIN KINASE
KINASE KINASE 7,
TGF-BETA-ACTIVATED
KINASE 1 AND
MAP3K7-BINDING
PROTEIN 1 CHIMERA

(Homo sapiens) 		PF07714
(Pkinase_Tyr) 		7 ALA A  61
LYS A  63
GLU A  77
LEU A  81
ILE A  89
HIS A 154
LEU A 163
 1UL  A 501 (-3.1A)
None
None
None
None
None
1UL  A 501 (-4.3A)
 0.81A 4c8bB-4l52A:
28.8		 4c8bB-4l52A:
29.38
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4m69 RECEPTOR-INTERACTING
SERINE/THREONINE-PRO
TEIN KINASE 3

(Mus musculus) 		PF00069
(Pkinase) 		7 ALA A  49
LYS A  51
LEU A  74
THR A  95
HIS A 141
LEU A 150
ALA A 160
 ANP  A 401 (-3.1A)
ANP  A 401 (-2.9A)
None
ANP  A 401 (-3.8A)
None
ANP  A 401 (-4.8A)
None
 0.93A 4c8bB-4m69A:
29.0		 4c8bB-4m69A:
34.19
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4o27 SERINE/THREONINE-PRO
TEIN KINASE 24

(Homo sapiens) 		PF00069
(Pkinase) 		7 ALA B  51
LYS B  53
GLU B  70
LEU B  74
HIS B 142
LEU B 151
ALA B 161
 ADP  B 500 (-3.3A)
ADP  B 500 (-3.1A)
None
None
None
ADP  B 500 (-4.7A)
None
 0.63A 4c8bB-4o27B:
24.8		 4c8bB-4o27B:
26.04
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4o27 SERINE/THREONINE-PRO
TEIN KINASE 24

(Homo sapiens) 		PF00069
(Pkinase) 		7 ALA B  51
LYS B  53
LEU B  74
HIS B 142
LEU B 151
ALA B 161
ASP B 162
 ADP  B 500 (-3.3A)
ADP  B 500 (-3.1A)
None
None
ADP  B 500 (-4.7A)
None
ADP  B 500 ( 3.4A)
 0.84A 4c8bB-4o27B:
24.8		 4c8bB-4o27B:
26.04
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4o38 CYCLIN-G-ASSOCIATED
KINASE

(Homo sapiens) 		PF00069
(Pkinase) 		7 ALA A  67
LYS A  69
GLU A  85
ILE A  98
THR A 123
HIS A 171
LEU A 180
 SIN  A 401 ( 3.7A)
None
None
None
None
None
SIN  A 401 ( 4.5A)
 0.68A 4c8bB-4o38A:
21.3		 4c8bB-4o38A:
25.68
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4rew 5'-AMP-ACTIVATED
PROTEIN KINASE
CATALYTIC SUBUNIT
ALPHA-1

(Homo sapiens) 		PF00069
(Pkinase)
PF16579
(AdenylateSensor) 		7 ALA A  45
LYS A  47
LEU A  70
ILE A  78
HIS A 139
LEU A 148
ALA A 158
 STU  A 601 (-3.2A)
STU  A 601 ( 3.7A)
None
None
None
STU  A 601 (-4.2A)
STU  A 601 ( 3.8A)
 0.93A 4c8bB-4rewA:
23.0		 4c8bB-4rewA:
21.65
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4rt7 RECEPTOR-TYPE
TYROSINE-PROTEIN
KINASE FLT3

(Homo sapiens) 		PF07714
(Pkinase_Tyr) 		8 ALA A 642
LYS A 644
GLU A 661
ILE A 674
HIS A 809
LEU A 818
ASP A 829
PHE A 830
 P30  A1001 (-3.4A)
P30  A1001 (-3.4A)
P30  A1001 (-3.6A)
None
P30  A1001 ( 4.3A)
P30  A1001 (-4.6A)
None
P30  A1001 (-3.9A)
 0.77A 4c8bB-4rt7A:
19.9		 4c8bB-4rt7A:
26.55
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ueu TYROSINE KINASE AS -
A COMMON ANCESTOR OF
SRC AND ABL

(synthetic
construct) 		PF07714
(Pkinase_Tyr) 		7 ALA A  35
LYS A  37
THR A  81
HIS A 127
LEU A 136
ALA A 146
ASP A 147
 ACP  A1264 (-2.9A)
None
ACP  A1264 (-4.5A)
None
ACP  A1264 ( 4.8A)
None
None
 0.75A 4c8bB-4ueuA:
27.0		 4c8bB-4ueuA:
26.28
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4xcu FIBROBLAST GROWTH
FACTOR RECEPTOR 4

(Homo sapiens) 		PF07714
(Pkinase_Tyr) 		7 ALA A 501
LYS A 503
GLU A 520
ILE A 533
HIS A 610
LEU A 619
ALA A 629
 40M  A1002 ( 4.1A)
40M  A1002 (-4.0A)
40M  A1002 (-3.7A)
None
None
40M  A1002 (-4.5A)
40M  A1002 (-3.0A)
 0.73A 4c8bB-4xcuA:
26.0		 4c8bB-4xcuA:
24.72
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4xuf RECEPTOR-TYPE
TYROSINE-PROTEIN
KINASE FLT3

(Homo sapiens) 		PF07714
(Pkinase_Tyr) 		8 ALA A 642
LYS A 644
GLU A 661
ILE A 674
HIS A 809
LEU A 818
ASP A 829
PHE A 830
 P30  A1001 (-3.5A)
P30  A1001 ( 4.0A)
P30  A1001 (-3.1A)
P30  A1001 (-4.3A)
P30  A1001 (-4.4A)
P30  A1001 (-4.3A)
None
P30  A1001 ( 4.1A)
 0.75A 4c8bB-4xufA:
26.0		 4c8bB-4xufA:
27.64
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4yff SERINE/THREONINE-PRO
TEIN KINASE TNNI3K

(Homo sapiens) 		PF07714
(Pkinase_Tyr) 		8 ALA A 488
LYS A 490
GLU A 509
LEU A 513
THR A 539
HIS A 586
LEU A 595
ALA A 605
 4CV  A 801 (-3.5A)
4CV  A 801 (-3.9A)
None
None
4CV  A 801 (-2.8A)
None
4CV  A 801 (-4.4A)
4CV  A 801 ( 3.9A)
 0.93A 4c8bB-4yffA:
25.2		 4c8bB-4yffA:
29.53
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ysj CALMODULIN-LIKE
DOMAIN PROTEIN
KINASE

(Eimeria tenella) 		PF00069
(Pkinase)
PF13499
(EF-hand_7) 		8 ALA A  55
LYS A  57
GLU A  76
LEU A  80
ILE A  88
THR A 105
HIS A 149
LEU A 158
 ADP  A 506 (-3.3A)
ADP  A 506 (-2.4A)
None
None
None
ADP  A 506 ( 4.6A)
None
ADP  A 506 (-4.7A)
 0.81A 4c8bB-4ysjA:
24.1		 4c8bB-4ysjA:
20.40
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5a46 FIBROBLAST GROWTH
FACTOR RECEPTOR 1
(FMS-RELATED
TYROSINE KINASE 2,
PFEIFFER SYNDROME),
ISOFORM CRA_B

(Homo sapiens) 		PF07714
(Pkinase_Tyr) 		7 ALA A 512
LYS A 514
GLU A 531
ILE A 544
HIS A 621
LEU A 630
ALA A 640
 38O  A1769 (-3.6A)
38O  A1769 ( 3.1A)
EDO  A1766 (-4.1A)
None
None
38O  A1769 (-4.6A)
EDO  A1766 ( 4.4A)
 0.67A 4c8bB-5a46A:
20.0		 4c8bB-5a46A:
25.31
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5d7a TRAF2 AND
NCK-INTERACTING
PROTEIN KINASE

(Homo sapiens) 		PF00069
(Pkinase) 		7 ALA A  52
LYS A  54
GLU A  69
LEU A  73
ILE A  82
HIS A 151
LEU A 160
 ALA  A  52 (-0.0A)
LYS  A  54 ( 0.0A)
GLU  A  69 ( 0.6A)
LEU  A  73 ( 0.6A)
ILE  A  82 ( 0.7A)
HIS  A 151 ( 1.0A)
LEU  A 160 (-0.6A)
 0.91A 4c8bB-5d7aA:
25.6		 4c8bB-5d7aA:
25.14
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5e8y TGF-BETA RECEPTOR
TYPE-2

(Homo sapiens) 		PF07714
(Pkinase_Tyr) 		7 ALA A 275
LYS A 277
GLU A 290
ILE A 304
LEU A 305
THR A 325
LEU A 386
 STU  A 601 (-3.1A)
STU  A 601 (-2.4A)
STU  A 601 ( 3.8A)
None
STU  A 601 ( 3.8A)
STU  A 601 ( 3.7A)
STU  A 601 (-3.9A)
 0.66A 4c8bB-5e8yA:
18.1		 4c8bB-5e8yA:
27.17
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5e8y TGF-BETA RECEPTOR
TYPE-2

(Homo sapiens) 		PF07714
(Pkinase_Tyr) 		7 ALA A 275
LYS A 277
ILE A 304
LEU A 305
THR A 325
HIS A 377
LEU A 386
 STU  A 601 (-3.1A)
STU  A 601 (-2.4A)
None
STU  A 601 ( 3.8A)
STU  A 601 ( 3.7A)
None
STU  A 601 (-3.9A)
 0.56A 4c8bB-5e8yA:
18.1		 4c8bB-5e8yA:
27.17
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5es1 MAP/MICROTUBULE
AFFINITY-REGULATING
KINASE 4

(Homo sapiens) 		PF00069
(Pkinase)
PF00627
(UBA) 		7 ALA A  83
LYS A  85
GLU A 103
ILE A 115
HIS A 176
LEU A 185
ALA A 195
 5RC  A4000 (-3.6A)
5RC  A4000 (-2.8A)
None
None
None
None
5RC  A4000 ( 3.9A)
 0.82A 4c8bB-5es1A:
23.0		 4c8bB-5es1A:
27.20
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5eyk AURORA KINASE B-A

(Xenopus laevis) 		PF00069
(Pkinase) 		7 ALA A 120
LYS A 122
ILE A 153
LEU A 154
LEU A 223
ALA A 233
ASP A 234
 5U5  A 401 (-3.5A)
5U5  A 401 (-2.6A)
None
5U5  A 401 (-4.8A)
5U5  A 401 (-4.7A)
None
None
 0.83A 4c8bB-5eykA:
23.3		 4c8bB-5eykA:
24.92
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5grn PLATELET-DERIVED
GROWTH FACTOR
RECEPTOR ALPHA

(Homo sapiens) 		PF07714
(Pkinase_Tyr) 		8 ALA A 625
LYS A 627
GLU A 644
ILE A 657
HIS A 816
LEU A 825
ASP A 836
PHE A 837
 748  A1001 (-3.7A)
748  A1001 (-4.0A)
748  A1001 (-3.3A)
748  A1001 ( 4.4A)
748  A1001 (-3.8A)
748  A1001 (-4.3A)
748  A1001 (-4.8A)
748  A1001 (-3.7A)
 0.76A 4c8bB-5grnA:
19.9		 4c8bB-5grnA:
27.37
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5grn PLATELET-DERIVED
GROWTH FACTOR
RECEPTOR ALPHA

(Homo sapiens) 		PF07714
(Pkinase_Tyr) 		8 ALA A 625
LYS A 627
GLU A 644
ILE A 657
THR A 674
HIS A 816
LEU A 825
ASP A 836
 748  A1001 (-3.7A)
748  A1001 (-4.0A)
748  A1001 (-3.3A)
748  A1001 ( 4.4A)
748  A1001 (-3.2A)
748  A1001 (-3.8A)
748  A1001 (-4.3A)
748  A1001 (-4.8A)
 0.48A 4c8bB-5grnA:
19.9		 4c8bB-5grnA:
27.37
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5hu3 CALCIUM/CALMODULIN-D
EPENDENT PROTEIN
KINASE TYPE II ALPHA
CHAIN

(Drosophila
melanogaster) 		PF00069
(Pkinase) 		7 ALA A  41
LYS A  43
GLU A  61
ILE A  73
HIS A 134
LEU A 143
ALA A 156
 ADP  A 301 (-3.5A)
ADP  A 301 (-2.7A)
None
None
None
ADP  A 301 (-4.7A)
ADP  A 301 ( 4.8A)
 0.58A 4c8bB-5hu3A:
24.4		 4c8bB-5hu3A:
24.57
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5j5t MITOGEN-ACTIVATED
PROTEIN KINASE
KINASE KINASE KINASE
3

(Homo sapiens) 		PF00069
(Pkinase) 		7 ALA A  43
LYS A  45
GLU A  61
ILE A  73
HIS A 134
LEU A 143
ALA A 153
 6G2  A 901 (-3.2A)
6G2  A 901 ( 3.9A)
None
None
None
6G2  A 901 (-4.7A)
6G2  A 901 ( 4.2A)
 0.56A 4c8bB-5j5tA:
11.2		 4c8bB-5j5tA:
25.41
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ko1 MIXED LINEAGE KINASE
DOMAIN-LIKE PROTEIN

(Homo sapiens) 		PF07714
(Pkinase_Tyr) 		7 ALA A 228
LYS A 230
ILE A 262
LEU A 263
HIS A 329
LEU A 338
ALA A 348
 6UY  A 501 (-3.4A)
6UY  A 501 (-4.0A)
None
None
None
6UY  A 501 (-4.5A)
6UY  A 501 (-3.4A)
 0.67A 4c8bB-5ko1A:
27.1		 4c8bB-5ko1A:
28.19
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5myv SRSF PROTEIN KINASE
2,SRSF PROTEIN
KINASE 2

(Homo sapiens) 		PF00069
(Pkinase) 		7 ALA A 119
LYS A 121
GLU A 136
LEU A 140
HIS A 223
LEU A 232
ALA A 540
 W4A  A 716 ( 3.9A)
SO4  A 702 (-3.3A)
DMS  A 717 (-4.0A)
None
None
None
DMS  A 717 ( 4.5A)
 0.85A 4c8bB-5myvA:
19.9		 4c8bB-5myvA:
22.60
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5xv7 SERINE-ARGININE (SR)
PROTEIN KINASE 1

(Homo sapiens) 		no annotation 7 ALA A 107
LYS A 109
GLU A 124
LEU A 128
HIS A 211
LEU A 220
ALA A 496
 EMH  A 705 (-3.6A)
EMH  A 705 ( 4.8A)
None
None
None
None
EMH  A 705 ( 4.0A)
 0.88A 4c8bB-5xv7A:
20.5		 4c8bB-5xv7A:
12.92
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5xzw SERINE/THREONINE-PRO
TEIN KINASE RAD53

(Saccharomyces
cerevisiae) 		no annotation 7 ALA A 225
LYS A 227
GLU A 244
LEU A 248
ILE A 256
HIS A 317
LEU A 326
 None
 0.79A 4c8bB-5xzwA:
19.2		 4c8bB-5xzwA:
21.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6b3e CYCLIN-DEPENDENT
KINASE 12

(Homo sapiens) 		no annotation 7 ALA A 754
LYS A 756
GLU A 774
LEU A 778
HIS A 857
LEU A 866
ALA A 876
 CJM  A1102 (-3.1A)
None
None
None
None
CJM  A1102 (-4.4A)
CJM  A1102 (-3.6A)
 0.81A 4c8bB-6b3eA:
24.0		 4c8bB-6b3eA:
12.23
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6bql CALCIUM/CALMODULIN-D
EPENDENT PROTEIN
KINASE KINASE 2

(Homo sapiens) 		no annotation 7 ALA A 192
LYS A 194
LEU A 240
HIS A 310
LEU A 319
ALA A 329
ASP A 330
 BI9  A 501 (-3.3A)
NH4  A 506 ( 4.4A)
None
None
BI9  A 501 (-4.7A)
NH4  A 506 ( 3.7A)
None
 0.89A 4c8bB-6bqlA:
22.7		 4c8bB-6bqlA:
14.05
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6c7y TYROSINE-PROTEIN
KINASE JAK1

(Homo sapiens) 		no annotation 7 ALA A 906
LYS A 908
GLU A 925
LEU A 929
ILE A 937
HIS A1001
LEU A1010
 ADP  A1201 (-3.4A)
ADP  A1201 (-2.8A)
None
None
None
None
ADP  A1201 (-4.5A)
 0.67A 4c8bB-6c7yA:
24.5		 4c8bB-6c7yA:
14.92
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6c9d SERINE/THREONINE-PRO
TEIN KINASE
MARK1,SERINE/THREONI
NE-PROTEIN KINASE
MARK1

(Homo sapiens) 		no annotation 7 ALA A  87
LYS A  89
GLU A 107
ILE A 119
HIS A 180
LEU A 189
ALA A 199
 None
 0.73A 4c8bB-6c9dA:
22.2		 4c8bB-6c9dA:
11.68
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6cmj CALCIUM/CALMODULIN-D
EPENDENT PROTEIN
KINASE KINASE 2

(Homo sapiens) 		no annotation 7 ALA A 192
LYS A 194
GLU A 236
LEU A 240
HIS A 310
LEU A 319
ALA A 329
 F6J  A 501 (-3.4A)
F6J  A 501 (-2.9A)
F6J  A 501 ( 4.7A)
None
None
F6J  A 501 (-4.5A)
F6J  A 501 ( 4.0A)
 0.93A 4c8bB-6cmjA:
16.4		 4c8bB-6cmjA:
15.60
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6cnh SERINE/THREONINE-PRO
TEIN KINASE PRP4
HOMOLOG

(Homo sapiens) 		no annotation 9 ALA A 715
LYS A 717
GLU A 732
LEU A 736
LEU A 751
HIS A 813
LEU A 822
ASP A 834
PHE A 835
 919  A1101 (-3.5A)
SO4  A1102 ( 2.8A)
919  A1101 (-3.7A)
None
919  A1101 (-4.5A)
919  A1101 (-4.2A)
None
919  A1101 (-4.5A)
919  A1101 ( 4.1A)
 0.71A 4c8bB-6cnhA:
22.0		 4c8bB-6cnhA:
13.67
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6cz4 PROTEIN-TYROSINE
KINASE 6

(Homo sapiens) 		no annotation 8 ALA A 217
ILE A 247
LEU A 248
THR A 264
HIS A 310
LEU A 319
ASP A 330
PHE A 331
 FKY  A9001 (-3.3A)
FKY  A9001 (-4.1A)
FKY  A9001 (-4.2A)
FKY  A9001 (-3.0A)
FKY  A9001 (-3.9A)
FKY  A9001 ( 4.9A)
None
FKY  A9001 (-3.9A)
 0.92A 4c8bB-6cz4A:
25.6		 4c8bB-6cz4A:
14.86
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1a1s ORNITHINE
CARBAMOYLTRANSFERASE

(Pyrococcus
furiosus) 		PF00185
(OTCace)
PF02729
(OTCace_N) 		3 TYR A 264
MET A 265
ILE A 152
 None
 0.81A 4c8bB-1a1sA:
undetectable		 4c8bB-1a1sA:
21.82
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1aug PYROGLUTAMYL
PEPTIDASE-1

(Bacillus
amyloliquefaciens) 		PF01470
(Peptidase_C15) 		3 TYR A 113
MET A 152
ILE A  65
 None
 0.86A 4c8bB-1augA:
undetectable		 4c8bB-1augA:
21.13
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ijq LOW-DENSITY
LIPOPROTEIN RECEPTOR

(Homo sapiens) 		PF00058
(Ldl_recept_b)
PF14670
(FXa_inhibition) 		3 TYR A 511
MET A 510
ILE A 467
 None
 0.74A 4c8bB-1ijqA:
undetectable		 4c8bB-1ijqA:
20.61
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1luf MUSCLE-SPECIFIC
TYROSINE KINASE
RECEPTOR MUSK

(Rattus
norvegicus) 		PF07714
(Pkinase_Tyr) 		3 TYR A 656
MET A 657
ILE A 637
 None
 0.55A 4c8bB-1lufA:
27.3		 4c8bB-1lufA:
27.42
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1luf MUSCLE-SPECIFIC
TYROSINE KINASE
RECEPTOR MUSK

(Rattus
norvegicus) 		PF07714
(Pkinase_Tyr) 		3 TYR A 656
MET A 657
ILE A 740
 None
 0.19A 4c8bB-1lufA:
27.3		 4c8bB-1lufA:
27.42
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1mox EPIDERMAL GROWTH
FACTOR RECEPTOR

(Homo sapiens) 		PF00757
(Furin-like)
PF01030
(Recep_L_domain) 		3 TYR A  88
MET A  87
ILE A 318
 None
 0.89A 4c8bB-1moxA:
undetectable		 4c8bB-1moxA:
21.39
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1n7d LOW-DENSITY
LIPOPROTEIN RECEPTOR

(Homo sapiens) 		PF00057
(Ldl_recept_a)
PF00058
(Ldl_recept_b)
PF07645
(EGF_CA)
PF14670
(FXa_inhibition) 		3 TYR A 511
MET A 510
ILE A 467
 None
 0.91A 4c8bB-1n7dA:
undetectable		 4c8bB-1n7dA:
17.14
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1o5w AMINE OXIDASE
[FLAVIN-CONTAINING]
A

(Rattus
norvegicus) 		PF01593
(Amino_oxidase) 		3 TYR A 410
MET A 300
ILE A 273
 None
None
FAD  A 652 (-3.6A)
 0.76A 4c8bB-1o5wA:
undetectable		 4c8bB-1o5wA:
22.55
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1zdx OUTER MEMBRANE USHER
PROTEIN FIMD

(Escherichia
coli) 		PF13954
(PapC_N) 		3 TYR A  43
MET A  44
ILE A 115
 None
 0.77A 4c8bB-1zdxA:
undetectable		 4c8bB-1zdxA:
18.02
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2a3n PUTATIVE
GLUCOSAMINE-FRUCTOSE
-6-PHOSPHATE
AMINOTRANSFERASE

(Salmonella
enterica) 		PF01380
(SIS) 		3 TYR A 208
MET A 209
ILE A 228
 None
 0.78A 4c8bB-2a3nA:
undetectable		 4c8bB-2a3nA:
22.37
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2ajr SUGAR KINASE, PFKB
FAMILY

(Thermotoga
maritima) 		PF00294
(PfkB) 		3 TYR A 299
MET A 300
ILE A  43
 None
 0.56A 4c8bB-2ajrA:
undetectable		 4c8bB-2ajrA:
24.40
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2dq7 PROTO-ONCOGENE
TYROSINE-PROTEIN
KINASE FYN

(Homo sapiens) 		PF07714
(Pkinase_Tyr) 		3 TYR X  84
MET X  85
ILE X 146
 STU  X 902 (-4.6A)
None
None
 0.16A 4c8bB-2dq7X:
26.3		 4c8bB-2dq7X:
26.11
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2ehj URACIL
PHOSPHORIBOSYLTRANSF
ERASE

(Escherichia
coli) 		PF14681
(UPRTase) 		3 TYR A 113
MET A 101
ILE A 143
 None
 0.68A 4c8bB-2ehjA:
undetectable		 4c8bB-2ehjA:
22.29
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2eqn HYPOTHETICAL PROTEIN
LOC92345

(Homo sapiens) 		PF04410
(Gar1) 		3 TYR A 101
MET A 100
ILE A  89
 None
 0.72A 4c8bB-2eqnA:
undetectable		 4c8bB-2eqnA:
14.76
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2fl1 RED FLUORESCENT
PROTEIN ZOANRFP

(Zoanthus sp.) 		PF01353
(GFP) 		3 TYR A 168
MET A 167
ILE A 200
 None
XYG  A  66 ( 3.2A)
None
 0.66A 4c8bB-2fl1A:
undetectable		 4c8bB-2fl1A:
18.90
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2ggt SCO1 PROTEIN
HOMOLOG,
MITOCHONDRIAL

(Homo sapiens) 		PF02630
(SCO1-SenC) 		3 TYR A 265
MET A 264
ILE A 181
 None
 0.88A 4c8bB-2ggtA:
undetectable		 4c8bB-2ggtA:
19.70
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2i6l MITOGEN-ACTIVATED
PROTEIN KINASE 6

(Homo sapiens) 		PF00069
(Pkinase) 		3 TYR A 110
MET A 111
ILE A  77
 None
 0.76A 4c8bB-2i6lA:
21.9		 4c8bB-2i6lA:
26.52
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2i6l MITOGEN-ACTIVATED
PROTEIN KINASE 6

(Homo sapiens) 		PF00069
(Pkinase) 		3 TYR A 110
MET A 111
ILE A 169
 None
 0.29A 4c8bB-2i6lA:
21.9		 4c8bB-2i6lA:
26.52
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2og8 PROTO-ONCOGENE
TYROSINE-PROTEIN
KINASE LCK

(Homo sapiens) 		PF07714
(Pkinase_Tyr) 		3 TYR A 318
MET A 319
ILE A 380
 1N8  A 501 ( 3.7A)
1N8  A 501 ( 4.4A)
None
 0.49A 4c8bB-2og8A:
27.1		 4c8bB-2og8A:
26.61
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2ogr FLUORESCENT PROTEIN
FP538

(Zoanthus sp.) 		PF01353
(GFP) 		3 TYR A 168
MET A 167
ILE A 200
 None
CH7  A  66 ( 3.2A)
None
 0.67A 4c8bB-2ogrA:
undetectable		 4c8bB-2ogrA:
22.02
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2okx RHAMNOSIDASE B

(Bacillus sp.
GL1) 		PF05592
(Bac_rhamnosid)
PF08531
(Bac_rhamnosid_N)
PF17389
(Bac_rhamnosid6H)
PF17390
(Bac_rhamnosid_C) 		3 TYR A 470
MET A 471
ILE A 441
 None
 0.62A 4c8bB-2okxA:
undetectable		 4c8bB-2okxA:
15.45
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2pmo SER/THR PROTEIN
KINASE

(Plasmodium
falciparum) 		PF00069
(Pkinase) 		3 TYR X 119
MET X 120
ILE X 178
 HMD  X 400 (-4.5A)
None
None
 0.92A 4c8bB-2pmoX:
3.2		 4c8bB-2pmoX:
25.53
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2pxs GFP-LIKE FLUORESCENT
CHROMOPROTEIN FP506

(Zoanthus sp.) 		PF01353
(GFP) 		3 TYR A 168
MET A 167
ILE A 200
 None
XYG  A  66 ( 3.1A)
None
 0.66A 4c8bB-2pxsA:
undetectable		 4c8bB-2pxsA:
20.30
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2qkw PROTEIN KINASE

(Solanum
pimpinellifolium) 		PF07714
(Pkinase_Tyr) 		3 TYR B 116
MET B 117
ILE B 180
 None
 0.44A 4c8bB-2qkwB:
24.6		 4c8bB-2qkwB:
30.09
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2r2p EPHRIN TYPE-A
RECEPTOR 5

(Homo sapiens) 		PF07714
(Pkinase_Tyr)
PF14575
(EphA2_TM) 		3 TYR A 755
MET A 756
ILE A 736
 None
 0.59A 4c8bB-2r2pA:
26.9		 4c8bB-2r2pA:
28.53
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2xyu EPHRIN TYPE-A
RECEPTOR 4,

(Mus musculus) 		PF07714
(Pkinase_Tyr) 		3 TYR A 701
MET A 702
ILE A 682
 Q9G  A1898 (-4.8A)
None
None
 0.58A 4c8bB-2xyuA:
27.8		 4c8bB-2xyuA:
28.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2y35 LD22664P

(Drosophila
melanogaster) 		PF03159
(XRN_N) 		3 TYR A 579
MET A 578
ILE A 180
 None
 0.72A 4c8bB-2y35A:
undetectable		 4c8bB-2y35A:
15.16
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2z5x AMINE OXIDASE
[FLAVIN-CONTAINING]
A

(Homo sapiens) 		PF01593
(Amino_oxidase) 		3 TYR A 410
MET A 300
ILE A 273
 None
None
FAD  A 600 (-3.9A)
 0.72A 4c8bB-2z5xA:
undetectable		 4c8bB-2z5xA:
20.93
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3bwu OUTER MEMBRANE USHER
PROTEIN FIMD,
N-TERMINAL DOMAIN

(Escherichia
coli) 		PF13954
(PapC_N) 		3 TYR D  43
MET D  44
ILE D 115
 None
 0.66A 4c8bB-3bwuD:
undetectable		 4c8bB-3bwuD:
18.25
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3dsb PUTATIVE
ACETYLTRANSFERASE

(Clostridioides
difficile) 		PF00583
(Acetyltransf_1) 		3 TYR A 153
MET A 152
ILE A 119
 None
 0.86A 4c8bB-3dsbA:
undetectable		 4c8bB-3dsbA:
19.27
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3gab DNA MISMATCH REPAIR
PROTEIN MUTL

(Bacillus
subtilis) 		PF08676
(MutL_C) 		3 TYR A 440
MET A 439
ILE A 612
 None
 0.81A 4c8bB-3gabA:
undetectable		 4c8bB-3gabA:
21.73
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3h0g DNA-DIRECTED RNA
POLYMERASE II
SUBUNIT RPB2

(Schizosaccharomyces
pombe) 		PF00562
(RNA_pol_Rpb2_6)
PF04560
(RNA_pol_Rpb2_7)
PF04561
(RNA_pol_Rpb2_2)
PF04563
(RNA_pol_Rpb2_1)
PF04565
(RNA_pol_Rpb2_3)
PF04566
(RNA_pol_Rpb2_4)
PF04567
(RNA_pol_Rpb2_5) 		3 TYR B1062
MET B1061
ILE B 813
 None
 0.92A 4c8bB-3h0gB:
undetectable		 4c8bB-3h0gB:
14.40
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3hrp UNCHARACTERIZED
PROTEIN

(Bacteroides
thetaiotaomicron) 		PF01833
(TIG) 		3 TYR A 153
MET A 154
ILE A 132
 None
 0.73A 4c8bB-3hrpA:
undetectable		 4c8bB-3hrpA:
20.86
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3jur EXO-POLY-ALPHA-D-GAL
ACTURONOSIDASE

(Thermotoga
maritima) 		PF00295
(Glyco_hydro_28)
PF12708
(Pectate_lyase_3) 		3 TYR A 440
MET A 426
ILE A 430
 None
 0.91A 4c8bB-3jurA:
undetectable		 4c8bB-3jurA:
21.48
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ko7 D-TYROSYL-TRNA(TYR)
DEACYLASE

(Plasmodium
falciparum) 		PF02580
(Tyr_Deacylase) 		3 TYR A 140
MET A 141
ILE A  85
 None
 0.77A 4c8bB-3ko7A:
undetectable		 4c8bB-3ko7A:
18.26
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3kul EPHRIN TYPE-A
RECEPTOR 8

(Homo sapiens) 		PF07714
(Pkinase_Tyr)
PF14575
(EphA2_TM) 		3 TYR A 715
MET A 716
ILE A 696
 GOL  A 403 (-4.1A)
None
None
 0.67A 4c8bB-3kulA:
27.2		 4c8bB-3kulA:
31.11
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3l6n METALLO-BETA-LACTAMA
SE

(Chryseobacterium
indologenes) 		PF00753
(Lactamase_B) 		3 TYR A  38
MET A  54
ILE A 216
 None
None
SO4  A 402 (-3.0A)
 0.68A 4c8bB-3l6nA:
undetectable		 4c8bB-3l6nA:
21.08
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3lvv GLUTAMATE--CYSTEINE
LIGASE

(Saccharomyces
cerevisiae) 		PF03074
(GCS) 		3 TYR A 254
MET A 255
ILE A 317
 None
None
LBP  A 693 (-4.7A)
 0.83A 4c8bB-3lvvA:
undetectable		 4c8bB-3lvvA:
17.31
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3m0c LOW-DENSITY
LIPOPROTEIN RECEPTOR

(Homo sapiens) 		PF00057
(Ldl_recept_a)
PF00058
(Ldl_recept_b)
PF07645
(EGF_CA)
PF14670
(FXa_inhibition) 		3 TYR C 511
MET C 510
ILE C 467
 None
 0.74A 4c8bB-3m0cC:
undetectable		 4c8bB-3m0cC:
18.53
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3mgf FLUORESCENT PROTEIN

(Verrillofungia
concinna) 		PF01353
(GFP) 		3 TYR A 163
MET A 162
ILE A 195
 None
CFY  A  66 ( 3.3A)
None
 0.67A 4c8bB-3mgfA:
undetectable		 4c8bB-3mgfA:
19.48
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3n23 SODIUM/POTASSIUM-TRA
NSPORTING ATPASE
SUBUNIT ALPHA-1

(Sus scrofa) 		PF00122
(E1-E2_ATPase)
PF00689
(Cation_ATPase_C)
PF00690
(Cation_ATPase_N)
PF13246
(Cation_ATPase) 		3 TYR A 974
MET A 973
ILE A 800
 None
None
OBN  A   1 ( 4.7A)
 0.79A 4c8bB-3n23A:
undetectable		 4c8bB-3n23A:
15.32
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3n7z ACETYLTRANSFERASE,
GNAT FAMILY

(Bacillus
anthracis) 		PF13527
(Acetyltransf_9)
PF13530
(SCP2_2) 		3 TYR A 213
MET A 214
ILE A 218
 None
 0.87A 4c8bB-3n7zA:
undetectable		 4c8bB-3n7zA:
21.12
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3oz6 MITOGEN-ACTIVATED
PROTEIN KINASE 1,
SERINE/THREONINE
PROTEIN KINASE

(Cryptosporidium
parvum) 		PF00069
(Pkinase) 		3 TYR A  92
MET A  93
ILE A  71
 None
 0.78A 4c8bB-3oz6A:
20.6		 4c8bB-3oz6A:
22.80
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3oz6 MITOGEN-ACTIVATED
PROTEIN KINASE 1,
SERINE/THREONINE
PROTEIN KINASE

(Cryptosporidium
parvum) 		PF00069
(Pkinase) 		3 TYR A  92
MET A  93
ILE A 140
 None
 0.87A 4c8bB-3oz6A:
20.6		 4c8bB-3oz6A:
22.80
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3p5b LOW DENSITY
LIPOPROTEIN RECEPTOR
VARIANT

(Homo sapiens) 		PF00058
(Ldl_recept_b)
PF07645
(EGF_CA)
PF14670
(FXa_inhibition) 		3 TYR L 511
MET L 510
ILE L 467
 None
 0.92A 4c8bB-3p5bL:
undetectable		 4c8bB-3p5bL:
21.94
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3pz9 MANNAN
ENDO-1,4-BETA-MANNOS
IDASE. GLYCOSYL
HYDROLASE FAMILY 5

(Thermotoga
petrophila) 		PF00150
(Cellulase) 		3 TYR A 318
MET A 348
ILE A  72
 None
 0.89A 4c8bB-3pz9A:
undetectable		 4c8bB-3pz9A:
22.82
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ujz METALLOPROTEASE STCE

(Escherichia
coli) 		PF10462
(Peptidase_M66) 		3 TYR A 710
MET A 709
ILE A 375
 None
 0.90A 4c8bB-3ujzA:
undetectable		 4c8bB-3ujzA:
16.82
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3v5q NT-3 GROWTH FACTOR
RECEPTOR

(Homo sapiens) 		PF07714
(Pkinase_Tyr) 		3 TYR A 619
MET A 620
ILE A 600
 0F4  A 902 (-4.2A)
None
0F4  A 902 (-4.1A)
 0.76A 4c8bB-3v5qA:
26.7		 4c8bB-3v5qA:
29.30
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3v5q NT-3 GROWTH FACTOR
RECEPTOR

(Homo sapiens) 		PF07714
(Pkinase_Tyr) 		3 TYR A 619
MET A 620
ILE A 695
 0F4  A 902 (-4.2A)
None
0F4  A 902 (-4.6A)
 0.39A 4c8bB-3v5qA:
26.7		 4c8bB-3v5qA:
29.30
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3wdy BETA-1,3-1,4-GLUCANA
SE

(Paecilomyces
sp.
'thermophila') 		no annotation 3 TYR A  52
MET A  53
ILE A 244
 None
 0.88A 4c8bB-3wdyA:
undetectable		 4c8bB-3wdyA:
22.16
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3zh4 UDP-N-ACETYLGLUCOSAM
INE
1-CARBOXYVINYLTRANSF
ERASE

(Streptococcus
pneumoniae) 		PF00275
(EPSP_synthase) 		3 TYR A 159
MET A 160
ILE A 169
 None
 0.58A 4c8bB-3zh4A:
undetectable		 4c8bB-3zh4A:
23.27
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3zq4 RIBONUCLEASE J 1

(Bacillus
subtilis) 		PF00753
(Lactamase_B)
PF07521
(RMMBL) 		3 TYR A 493
MET A 494
ILE A 468
 None
 0.76A 4c8bB-3zq4A:
undetectable		 4c8bB-3zq4A:
20.89
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4aah METHANOL
DEHYDROGENASE

(Methylophilus
methylotrophus) 		PF13360
(PQQ_2) 		3 TYR A  66
MET A  65
ILE A 522
 None
 0.88A 4c8bB-4aahA:
undetectable		 4c8bB-4aahA:
20.24
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4at3 BDNF/NT-3 GROWTH
FACTORS RECEPTOR

(Homo sapiens) 		PF07714
(Pkinase_Tyr) 		3 TYR A 635
MET A 636
ILE A 616
 LTI  A1839 (-4.7A)
None
None
 0.77A 4c8bB-4at3A:
27.2		 4c8bB-4at3A:
28.49
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4at3 BDNF/NT-3 GROWTH
FACTORS RECEPTOR

(Homo sapiens) 		PF07714
(Pkinase_Tyr) 		3 TYR A 635
MET A 636
ILE A 708
 LTI  A1839 (-4.7A)
None
None
 0.48A 4c8bB-4at3A:
27.2		 4c8bB-4at3A:
28.49
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4b9w TUDOR
DOMAIN-CONTAINING
PROTEIN 1

(Mus musculus) 		PF00567
(TUDOR) 		3 TYR A 718
MET A 717
ILE A 878
 None
 0.90A 4c8bB-4b9wA:
undetectable		 4c8bB-4b9wA:
21.11
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4cdg NANOBODY

(Lama glama) 		PF07686
(V-set) 		3 TYR C 101
MET C 100
ILE C  72
 None
 0.85A 4c8bB-4cdgC:
undetectable		 4c8bB-4cdgC:
17.37
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ckr EPITHELIAL DISCOIDIN
DOMAIN-CONTAINING
RECEPTOR 1

(Homo sapiens) 		PF07714
(Pkinase_Tyr) 		3 TYR A 703
MET A 704
ILE A 684
 DI1  A1000 (-4.0A)
None
DI1  A1000 ( 4.5A)
 0.61A 4c8bB-4ckrA:
25.5		 4c8bB-4ckrA:
26.40
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ckr EPITHELIAL DISCOIDIN
DOMAIN-CONTAINING
RECEPTOR 1

(Homo sapiens) 		PF07714
(Pkinase_Tyr) 		3 TYR A 703
MET A 704
ILE A 782
 DI1  A1000 (-4.0A)
None
DI1  A1000 (-4.5A)
 0.55A 4c8bB-4ckrA:
25.5		 4c8bB-4ckrA:
26.40
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4f0i HIGH AFFINITY NERVE
GROWTH FACTOR
RECEPTOR

(Homo sapiens) 		PF07714
(Pkinase_Tyr) 		3 TYR A 590
MET A 591
ILE A 571
 None
 0.68A 4c8bB-4f0iA:
26.6		 4c8bB-4f0iA:
28.17
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4f0i HIGH AFFINITY NERVE
GROWTH FACTOR
RECEPTOR

(Homo sapiens) 		PF07714
(Pkinase_Tyr) 		3 TYR A 590
MET A 591
ILE A 665
 None
 0.41A 4c8bB-4f0iA:
26.6		 4c8bB-4f0iA:
28.17
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4j1y COMPLEMENT C1S
SUBCOMPONENT

(Homo sapiens) 		PF00084
(Sushi)
PF00089
(Trypsin) 		3 TYR A 390
MET A 541
ILE A 465
 None
 0.91A 4c8bB-4j1yA:
undetectable		 4c8bB-4j1yA:
21.53
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4j3o OUTER MEMBRANE USHER
PROTEIN FIMD

(Escherichia
coli) 		PF00577
(Usher)
PF13953
(PapC_C)
PF13954
(PapC_N) 		3 TYR D  43
MET D  44
ILE D 115
 None
 0.75A 4c8bB-4j3oD:
undetectable		 4c8bB-4j3oD:
16.94
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4jrf PUTATIVE CELL
ADHESION PROTEIN

(Bacteroides
ovatus) 		PF15495
(Fimbrillin_C) 		3 TYR A 272
MET A 311
ILE A 445
 None
CA  A 601 ( 4.5A)
None
 0.76A 4c8bB-4jrfA:
undetectable		 4c8bB-4jrfA:
20.79
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4k90 EXTRACELLULAR
METALLOPROTEINASE
MEP

(Aspergillus
fumigatus) 		PF02128
(Peptidase_M36) 		3 TYR A 409
MET A 408
ILE A 428
 None
 0.74A 4c8bB-4k90A:
undetectable		 4c8bB-4k90A:
19.61
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4kcb ARABINAN
ENDO-1,5-ALPHA-L-ARA
BINOSIDASE

(uncultured
bacterium) 		PF04616
(Glyco_hydro_43) 		3 TYR A 110
MET A 109
ILE A  52
 None
 0.91A 4c8bB-4kcbA:
undetectable		 4c8bB-4kcbA:
20.68
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4kml NANOBODY

(Lama glama) 		PF07686
(V-set) 		3 TYR B  80
MET B  79
ILE B 104
 None
 0.88A 4c8bB-4kmlB:
undetectable		 4c8bB-4kmlB:
19.42
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4l68 LEUCINE-RICH REPEAT
PROTEIN KINASE-LIKE
PROTEIN

(Arabidopsis
thaliana) 		PF07714
(Pkinase_Tyr) 		3 TYR A 381
MET A 382
ILE A 445
 None
 0.48A 4c8bB-4l68A:
21.3		 4c8bB-4l68A:
27.90
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4mh1 SORBOSE
DEHYDROGENASE

(Ketogulonicigenium
vulgare) 		PF13360
(PQQ_2) 		3 TYR A  68
MET A  67
ILE A 519
 None
 0.92A 4c8bB-4mh1A:
undetectable		 4c8bB-4mh1A:
20.31
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4mio INOSITOL
2-DEHYDROGENASE/D-CH
IRO-INOSITOL
3-DEHYDROGENASE

(Lactobacillus
casei) 		PF01408
(GFO_IDH_MocA) 		3 TYR A 129
MET A 126
ILE A 275
 None
NAI  A 401 ( 3.7A)
None
 0.83A 4c8bB-4mioA:
undetectable		 4c8bB-4mioA:
21.21
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4p2k EPHRIN TYPE-A
RECEPTOR 2

(Homo sapiens) 		PF07714
(Pkinase_Tyr)
PF14575
(EphA2_TM) 		3 TYR A 694
MET A 695
ILE A 675
 None
 0.82A 4c8bB-4p2kA:
27.0		 4c8bB-4p2kA:
28.12
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4p2k EPHRIN TYPE-A
RECEPTOR 2

(Homo sapiens) 		PF07714
(Pkinase_Tyr)
PF14575
(EphA2_TM) 		3 TYR A 694
MET A 695
ILE A 745
 None
 0.88A 4c8bB-4p2kA:
27.0		 4c8bB-4p2kA:
28.12
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ptf DNA POLYMERASE
EPSILON CATALYTIC
SUBUNIT A

(Saccharomyces
cerevisiae) 		PF00136
(DNA_pol_B)
PF03104
(DNA_pol_B_exo1) 		3 TYR A 120
MET A  82
ILE A 500
 None
 0.88A 4c8bB-4ptfA:
2.4		 4c8bB-4ptfA:
15.30
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4qiw DNA-DIRECTED RNA
POLYMERASE, SUBUNIT
E'
DNA-DIRECTED RNA
POLYMERASE, SUBUNIT
F

(Thermococcus
kodakarensis) 		PF00575
(S1)
PF03874
(RNA_pol_Rpb4)
PF03876
(SHS2_Rpb7-N) 		3 TYR E   2
MET E   1
ILE F  77
 None
 0.57A 4c8bB-4qiwE:
undetectable		 4c8bB-4qiwE:
19.76
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4tqo METHANOL
DEHYDROGENASE
PROTEIN, LARGE
SUBUNIT

(Methylococcus
capsulatus) 		no annotation 3 TYR B  94
MET B  93
ILE B 552
 None
 0.85A 4c8bB-4tqoB:
undetectable		 4c8bB-4tqoB:
18.93
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4xjv S-ACYL FATTY ACID
SYNTHASE
THIOESTERASE, MEDIUM
CHAIN

(Homo sapiens) 		PF00975
(Thioesterase) 		3 TYR A 105
MET A 102
ILE A 179
 None
 0.87A 4c8bB-4xjvA:
undetectable		 4c8bB-4xjvA:
21.08
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4yzt CELLULOSE HYDROLASE

(Bacillus
licheniformis) 		PF00150
(Cellulase)
PF03442
(CBM_X2) 		3 TYR A 269
MET A 299
ILE A  70
 None
 0.82A 4c8bB-4yztA:
undetectable		 4c8bB-4yztA:
22.88
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5aw4 NA, K-ATPASE ALPHA
SUBUNIT

(Squalus
acanthias) 		PF00122
(E1-E2_ATPase)
PF00689
(Cation_ATPase_C)
PF00690
(Cation_ATPase_N)
PF13246
(Cation_ATPase) 		3 TYR A 981
MET A 980
ILE A 807
 None
 0.85A 4c8bB-5aw4A:
undetectable		 4c8bB-5aw4A:
16.20
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5aw4 NA, K-ATPASE ALPHA
SUBUNIT

(Squalus
acanthias) 		PF00122
(E1-E2_ATPase)
PF00689
(Cation_ATPase_C)
PF00690
(Cation_ATPase_N)
PF13246
(Cation_ATPase) 		3 TYR A 981
MET A 980
ILE A 926
 None
 0.90A 4c8bB-5aw4A:
undetectable		 4c8bB-5aw4A:
16.20
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5b4x LOW DENSITY
LIPOPROTEIN
RECEPTOR-RELATED
PROTEIN 8,
APOLIPOPROTEIN E
RECEPTOR, ISOFORM
CRA_E

(Homo sapiens) 		PF00057
(Ldl_recept_a)
PF00058
(Ldl_recept_b)
PF07645
(EGF_CA)
PF14670
(FXa_inhibition) 		3 TYR B 425
MET B 424
ILE B 381
 None
 0.66A 4c8bB-5b4xB:
undetectable		 4c8bB-5b4xB:
19.51
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5e24 SUPPRESSOR OF
HAIRLESS PROTEIN

(Drosophila
melanogaster) 		PF09270
(BTD)
PF09271
(LAG1-DNAbind) 		3 TYR E 363
MET E 364
ILE E 380
 None
EDO  E 612 (-4.9A)
None
 0.92A 4c8bB-5e24E:
undetectable		 4c8bB-5e24E:
21.10
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5g06 EXOSOME COMPLEX
COMPONENT SKI6

(Saccharomyces
cerevisiae) 		PF01138
(RNase_PH)
PF03725
(RNase_PH_C) 		3 TYR B  41
MET B  42
ILE B 140
 None
 0.76A 4c8bB-5g06B:
undetectable		 4c8bB-5g06B:
22.25
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5gqf LACTO-N-BIOSIDASE

(Bifidobacterium
longum) 		no annotation 3 TYR A 531
MET A 530
ILE A 592
 None
 0.83A 4c8bB-5gqfA:
undetectable		 4c8bB-5gqfA:
19.19
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5hx6 RECEPTOR-INTERACTING
SERINE/THREONINE-PRO
TEIN KINASE 1

(Homo sapiens) 		PF07714
(Pkinase_Tyr) 		3 TYR A  94
MET A  95
ILE A 144
 None
 0.80A 4c8bB-5hx6A:
23.2		 4c8bB-5hx6A:
32.67
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5hx6 RECEPTOR-INTERACTING
SERINE/THREONINE-PRO
TEIN KINASE 1

(Homo sapiens) 		PF07714
(Pkinase_Tyr) 		3 TYR A  94
MET A  95
ILE A 154
 None
None
65U  A 301 (-4.1A)
 0.32A 4c8bB-5hx6A:
23.2		 4c8bB-5hx6A:
32.67
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ls6 HISTONE-LYSINE
N-METHYLTRANSFERASE
EZH2,HISTONE-LYSINE
N-METHYLTRANSFERASE
EZH2,HISTONE-LYSINE
N-METHYLTRANSFERASE
EZH2

(Homo sapiens) 		PF00856
(SET)
PF11616
(EZH2_WD-Binding) 		3 TYR A 111
MET A 110
ILE A 626
 74D  A 809 (-3.8A)
None
None
 0.90A 4c8bB-5ls6A:
undetectable		 4c8bB-5ls6A:
17.37
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5oki DNA POLYMERASE
EPSILON CATALYTIC
SUBUNIT A

(Saccharomyces
cerevisiae) 		no annotation 3 TYR A 120
MET A  82
ILE A 500
 None
 0.90A 4c8bB-5okiA:
undetectable		 4c8bB-5okiA:
14.06
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5tpv WLARA,
TDP-FUCOSE-3,4-KETOI
SOMERASE

(Campylobacter
jejuni) 		PF05523
(FdtA) 		3 TYR A  98
MET A  97
ILE A  59
 None
 0.90A 4c8bB-5tpvA:
undetectable		 4c8bB-5tpvA:
18.81
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5w5j RECEPTOR-INTERACTING
SERINE/THREONINE-PRO
TEIN KINASE 2

(Homo sapiens) 		no annotation 3 TYR A  97
MET A  98
ILE A  78
 None
 0.66A 4c8bB-5w5jA:
35.6		 4c8bB-5w5jA:
92.99
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5w5j RECEPTOR-INTERACTING
SERINE/THREONINE-PRO
TEIN KINASE 2

(Homo sapiens) 		no annotation 3 TYR A  97
MET A  98
ILE A 152
 None
 0.78A 4c8bB-5w5jA:
35.6		 4c8bB-5w5jA:
92.99
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5w5j RECEPTOR-INTERACTING
SERINE/THREONINE-PRO
TEIN KINASE 2

(Homo sapiens) 		no annotation 3 TYR A  97
MET A  98
ILE A 162
 None
 0.17A 4c8bB-5w5jA:
35.6		 4c8bB-5w5jA:
92.99
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5wg6 HISTONE-LYSINE
N-METHYLTRANSFERASE
EZH2,POLYCOMB
PROTEIN SUZ12
(E.C.2.1.1.43)
CHIMERA

(Homo sapiens) 		no annotation 3 TYR A 111
MET A 110
ILE A 626
 None
A9G  A9009 ( 4.3A)
None
 0.92A 4c8bB-5wg6A:
undetectable		 4c8bB-5wg6A:
13.47
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5wnm RECEPTOR-INTERACTING
SERINE/THREONINE-PRO
TEIN KINASE 4

(Mus musculus) 		no annotation 3 TYR A  98
MET A  99
ILE A  81
 VX6  A 402 (-4.3A)
None
None
 0.59A 4c8bB-5wnmA:
31.0		 4c8bB-5wnmA:
12.73
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5wnm RECEPTOR-INTERACTING
SERINE/THREONINE-PRO
TEIN KINASE 4

(Mus musculus) 		no annotation 3 TYR A  98
MET A  99
ILE A 159
 VX6  A 402 (-4.3A)
None
None
 0.27A 4c8bB-5wnmA:
31.0		 4c8bB-5wnmA:
12.73
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5xog DNA-DIRECTED RNA
POLYMERASE SUBUNIT
BETA

(Komagataella
phaffii) 		PF00562
(RNA_pol_Rpb2_6)
PF04560
(RNA_pol_Rpb2_7)
PF04561
(RNA_pol_Rpb2_2)
PF04563
(RNA_pol_Rpb2_1)
PF04565
(RNA_pol_Rpb2_3)
PF04566
(RNA_pol_Rpb2_4)
PF04567
(RNA_pol_Rpb2_5) 		3 TYR B1073
MET B1072
ILE B 824
 None
 0.88A 4c8bB-5xogB:
undetectable		 4c8bB-5xogB:
14.27
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5y3r DNA-DEPENDENT
PROTEIN KINASE
CATALYTIC SUBUNIT

(Homo sapiens) 		PF00454
(PI3_PI4_kinase)
PF02259
(FAT)
PF02260
(FATC)
PF08163
(NUC194) 		3 TYR C 788
MET C 785
ILE C 778
 None
 0.77A 4c8bB-5y3rC:
undetectable		 4c8bB-5y3rC:
5.88
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5yh5 NICKEL ABC
TRANSPORTER
SUBSTRATE-BINDING
PROTEIN

(Staphylococcus
aureus) 		no annotation 3 TYR A 353
MET A 352
ILE A 472
 None
 0.88A 4c8bB-5yh5A:
undetectable		 4c8bB-5yh5A:
12.50
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6f3d INTERLEUKIN-1
RECEPTOR-ASSOCIATED
KINASE 4

(Homo sapiens) 		no annotation 3 TYR A 264
MET A 265
ILE A 317
 CJT  A 502 (-4.5A)
CJT  A 502 (-4.9A)
None
 0.85A 4c8bB-6f3dA:
25.0		 4c8bB-6f3dA:
12.28
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6f3d INTERLEUKIN-1
RECEPTOR-ASSOCIATED
KINASE 4

(Homo sapiens) 		no annotation 3 TYR A 264
MET A 265
ILE A 327
 CJT  A 502 (-4.5A)
CJT  A 502 (-4.9A)
None
 0.46A 4c8bB-6f3dA:
25.0		 4c8bB-6f3dA:
12.28
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6gun -

(-) 		no annotation 3 TYR A 219
MET A 218
ILE A 189
 None
 0.82A 4c8bB-6gunA:
undetectable		 4c8bB-6gunA:
undetectable