SIMILAR PATTERNS OF AMINO ACIDS FOR 4C8B_A_0LIA1000_2

List of similar pattern of amino acids derived from ASSAM search

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click link on the last column to view superposed patterns of amino acids in NGL viewer)
(Note that only 3-12 residue patterns can be used for ASSAM searches)
Filter list by:
Hit Macromolecule/
Organism		 Pfam Res. Interface HETATM RMSD Dali Z-score Seq. Identity (%) View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ehk BA3-TYPE
CYTOCHROME-C OXIDASE

(Thermus
thermophilus) 		PF00115
(COX1) 		4 VAL A 163
ILE A 250
MET A 185
ILE A 246
 None
 0.82A 4c8bA-1ehkA:
undetectable		 4c8bA-1ehkA:
21.49
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1luf MUSCLE-SPECIFIC
TYROSINE KINASE
RECEPTOR MUSK

(Rattus
norvegicus) 		PF07714
(Pkinase_Tyr) 		5 VAL A 588
ILE A 637
TYR A 656
MET A 657
ILE A 740
 None
 0.45A 4c8bA-1lufA:
27.8		 4c8bA-1lufA:
27.42
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1py5 TGF-BETA RECEPTOR
TYPE I

(Homo sapiens) 		PF00069
(Pkinase)
PF08515
(TGF_beta_GS) 		4 VAL A 219
ILE A 259
TYR A 282
ILE A 349
 PY1  A 700 ( 4.7A)
None
PY1  A 700 (-4.6A)
None
 0.70A 4c8bA-1py5A:
18.5		 4c8bA-1py5A:
26.18
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1qyi HYPOTHETICAL PROTEIN

(Staphylococcus
aureus) 		PF13242
(Hydrolase_like) 		4 VAL A 111
ILE A  87
TYR A  35
ILE A  83
 None
 0.89A 4c8bA-1qyiA:
undetectable		 4c8bA-1qyiA:
23.71
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1rjb FL CYTOKINE RECEPTOR

(Homo sapiens) 		PF07714
(Pkinase_Tyr) 		4 VAL A 624
ILE A 674
TYR A 693
ILE A 827
 None
 0.45A 4c8bA-1rjbA:
25.5		 4c8bA-1rjbA:
25.85
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1t46 HOMO SAPIENS V-KIT
HARDY-ZUCKERMAN 4
FELINE SARCOMA VIRAL
ONCOGENE HOMOLOG

(Homo sapiens) 		PF07714
(Pkinase_Tyr) 		4 VAL A 603
ILE A 653
TYR A 672
ILE A 808
 STI  A   3 ( 4.6A)
None
STI  A   3 ( 4.0A)
None
 0.44A 4c8bA-1t46A:
27.3		 4c8bA-1t46A:
26.68
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ttu LIN-12 AND GLP-1
TRANSCRIPTIONAL
REGULATOR

(Caenorhabditis
elegans) 		PF01833
(TIG)
PF09270
(BTD)
PF09271
(LAG1-DNAbind) 		4 VAL A 479
ILE A 515
MET A 500
ILE A 516
 None
 0.94A 4c8bA-1ttuA:
undetectable		 4c8bA-1ttuA:
20.49
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2b1p MITOGEN-ACTIVATED
PROTEIN KINASE 10

(Homo sapiens) 		PF00069
(Pkinase) 		4 VAL A  78
ILE A 123
MET A 149
ILE A 205
 AIZ  A 501 ( 4.7A)
None
None
None
 0.50A 4c8bA-2b1pA:
20.1		 4c8bA-2b1pA:
23.58
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2b1p MITOGEN-ACTIVATED
PROTEIN KINASE 10

(Homo sapiens) 		PF00069
(Pkinase) 		4 VAL A  78
ILE A 205
MET A 149
ILE A 195
 AIZ  A 501 ( 4.7A)
None
None
None
 0.93A 4c8bA-2b1pA:
20.1		 4c8bA-2b1pA:
23.58
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2dq7 PROTO-ONCOGENE
TYROSINE-PROTEIN
KINASE FYN

(Homo sapiens) 		PF07714
(Pkinase_Tyr) 		4 VAL X  25
TYR X  84
MET X  85
ILE X 146
 STU  X 902 ( 4.8A)
STU  X 902 (-4.6A)
None
None
 0.33A 4c8bA-2dq7X:
26.6		 4c8bA-2dq7X:
26.11
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2hak SERINE/THREONINE-PRO
TEIN KINASE MARK1

(Homo sapiens) 		PF00069
(Pkinase)
PF00627
(UBA) 		4 VAL A  67
ILE A 112
TYR A 131
ILE A 191
 None
 0.79A 4c8bA-2hakA:
20.1		 4c8bA-2hakA:
25.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2i6l MITOGEN-ACTIVATED
PROTEIN KINASE 6

(Homo sapiens) 		PF00069
(Pkinase) 		5 VAL A  34
ILE A  77
TYR A 110
MET A 111
ILE A 169
 None
 0.50A 4c8bA-2i6lA:
21.7		 4c8bA-2i6lA:
26.52
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2og8 PROTO-ONCOGENE
TYROSINE-PROTEIN
KINASE LCK

(Homo sapiens) 		PF07714
(Pkinase_Tyr) 		4 VAL A 259
TYR A 318
MET A 319
ILE A 380
 None
1N8  A 501 ( 3.7A)
1N8  A 501 ( 4.4A)
None
 0.74A 4c8bA-2og8A:
27.1		 4c8bA-2og8A:
26.61
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2ogv MACROPHAGE
COLONY-STIMULATING
FACTOR 1 RECEPTOR
PRECURSOR

(Homo sapiens) 		PF07714
(Pkinase_Tyr) 		4 VAL A 596
ILE A 646
TYR A 665
ILE A 794
 None
 0.72A 4c8bA-2ogvA:
25.9		 4c8bA-2ogvA:
26.14
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2p4i ANGIOPOIETIN-1
RECEPTOR

(Homo sapiens) 		PF07714
(Pkinase_Tyr) 		4 VAL A 838
ILE A 885
TYR A 904
ILE A 980
 MR9  A 301 (-4.6A)
MR9  A 301 ( 4.5A)
MR9  A 301 (-3.8A)
MR9  A 301 (-4.6A)
 0.80A 4c8bA-2p4iA:
9.8		 4c8bA-2p4iA:
25.75
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2psq FIBROBLAST GROWTH
FACTOR RECEPTOR 2

(Homo sapiens) 		PF07714
(Pkinase_Tyr) 		4 VAL A 495
ILE A 547
TYR A 566
ILE A 642
 None
 0.58A 4c8bA-2psqA:
26.9		 4c8bA-2psqA:
26.12
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2qkw PROTEIN KINASE

(Solanum
pimpinellifolium) 		PF07714
(Pkinase_Tyr) 		5 VAL B  55
ILE B 180
TYR B 116
MET B 117
ILE B 170
 None
 1.16A 4c8bA-2qkwB:
24.8		 4c8bA-2qkwB:
30.09
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2r2p EPHRIN TYPE-A
RECEPTOR 5

(Homo sapiens) 		PF07714
(Pkinase_Tyr)
PF14575
(EphA2_TM) 		4 VAL A 689
ILE A 736
TYR A 755
MET A 756
 None
 0.65A 4c8bA-2r2pA:
27.3		 4c8bA-2r2pA:
28.53
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2xjq FLOCCULATION PROTEIN
FLO5

(Saccharomyces
cerevisiae) 		PF07691
(PA14) 		4 VAL A 136
ILE A 233
TYR A  83
ILE A  79
 None
 0.74A 4c8bA-2xjqA:
undetectable		 4c8bA-2xjqA:
21.73
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2xk9 CHECKPOINT KINASE 2

(Homo sapiens) 		PF00069
(Pkinase) 		4 VAL A 234
ILE A 285
MET A 304
ILE A 366
 XK9  A1511 (-4.8A)
None
None
None
 0.65A 4c8bA-2xk9A:
21.9		 4c8bA-2xk9A:
26.65
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2xyu EPHRIN TYPE-A
RECEPTOR 4,

(Mus musculus) 		PF07714
(Pkinase_Tyr) 		4 VAL A 635
ILE A 682
TYR A 701
MET A 702
 Q9G  A1898 ( 4.7A)
None
Q9G  A1898 (-4.8A)
None
 0.37A 4c8bA-2xyuA:
27.9		 4c8bA-2xyuA:
28.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2yxe PROTEIN-L-ISOASPARTA
TE
O-METHYLTRANSFERASE

(Methanocaldococcus
jannaschii) 		PF01135
(PCMT) 		4 VAL A  99
ILE A 133
TYR A 127
ILE A 108
 None
 0.93A 4c8bA-2yxeA:
undetectable		 4c8bA-2yxeA:
21.62
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3b2t FIBROBLAST GROWTH
FACTOR RECEPTOR 2

(Homo sapiens) 		PF07714
(Pkinase_Tyr) 		4 VAL A 495
ILE A 547
TYR A 566
ILE A 642
 M33  A1996 ( 4.7A)
None
M33  A1996 ( 4.7A)
None
 0.41A 4c8bA-3b2tA:
19.6		 4c8bA-3b2tA:
24.73
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3bwu OUTER MEMBRANE USHER
PROTEIN FIMD,
N-TERMINAL DOMAIN

(Escherichia
coli) 		PF13954
(PapC_N) 		4 VAL D  35
ILE D 115
TYR D  43
MET D  44
 None
 0.90A 4c8bA-3bwuD:
undetectable		 4c8bA-3bwuD:
18.25
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3c4f BASIC FIBROBLAST
GROWTH FACTOR
RECEPTOR 1

(Homo sapiens) 		PF07714
(Pkinase_Tyr) 		4 VAL A 492
ILE A 544
TYR A 563
ILE A 639
 None
 0.67A 4c8bA-3c4fA:
26.5		 4c8bA-3c4fA:
26.35
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3e7o MITOGEN-ACTIVATED
PROTEIN KINASE 9

(Homo sapiens) 		PF00069
(Pkinase) 		4 VAL A  40
ILE A  85
MET A 111
ILE A 167
 35F  A   1 ( 4.8A)
None
None
None
 0.25A 4c8bA-3e7oA:
21.0		 4c8bA-3e7oA:
23.51
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3e7o MITOGEN-ACTIVATED
PROTEIN KINASE 9

(Homo sapiens) 		PF00069
(Pkinase) 		4 VAL A  40
ILE A 167
MET A 111
ILE A 157
 35F  A   1 ( 4.8A)
None
None
None
 0.89A 4c8bA-3e7oA:
21.0		 4c8bA-3e7oA:
23.51
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3fe3 MAP/MICROTUBULE
AFFINITY-REGULATING
KINASE 3

(Homo sapiens) 		PF00069
(Pkinase)
PF00627
(UBA) 		4 VAL A  70
ILE A 115
TYR A 134
ILE A 194
 None
 0.82A 4c8bA-3fe3A:
21.7		 4c8bA-3fe3A:
24.38
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ffs INOSINE-5-MONOPHOSPH
ATE DEHYDROGENASE

(Cryptosporidium
parvum) 		PF00478
(IMPDH) 		4 VAL A 161
ILE A 255
MET A  50
ILE A 274
 None
 0.94A 4c8bA-3ffsA:
undetectable		 4c8bA-3ffsA:
23.73
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3g2f BONE MORPHOGENETIC
PROTEIN RECEPTOR
TYPE-2

(Homo sapiens) 		PF00069
(Pkinase) 		4 VAL A 217
ILE A 257
TYR A 281
ILE A 349
 ADP  A 900 (-4.3A)
None
None
None
 0.58A 4c8bA-3g2fA:
24.1		 4c8bA-3g2fA:
27.61
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3gbz KINASE, CMGC CDK

(Giardia
intestinalis) 		PF00069
(Pkinase) 		4 VAL A  29
ILE A  74
TYR A  93
ILE A 157
 None
 0.61A 4c8bA-3gbzA:
22.4		 4c8bA-3gbzA:
28.10
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3i6u SERINE/THREONINE-PRO
TEIN KINASE CHK2

(Homo sapiens) 		PF00069
(Pkinase)
PF00498
(FHA) 		4 VAL A 234
ILE A 285
MET A 304
ILE A 366
 None
 0.46A 4c8bA-3i6uA:
23.2		 4c8bA-3i6uA:
22.42
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3iec SERINE/THREONINE-PRO
TEIN KINASE MARK2

(Homo sapiens) 		PF00069
(Pkinase)
PF00627
(UBA) 		4 VAL A  67
ILE A 112
TYR A 131
ILE A 191
 None
 0.51A 4c8bA-3iecA:
22.6		 4c8bA-3iecA:
26.04
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3kul EPHRIN TYPE-A
RECEPTOR 8

(Homo sapiens) 		PF07714
(Pkinase_Tyr)
PF14575
(EphA2_TM) 		4 VAL A 649
ILE A 696
TYR A 715
MET A 716
 None
None
GOL  A 403 (-4.1A)
None
 0.63A 4c8bA-3kulA:
27.6		 4c8bA-3kulA:
31.11
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3mdy BONE MORPHOGENETIC
PROTEIN RECEPTOR
TYPE-1B

(Homo sapiens) 		PF07714
(Pkinase_Tyr)
PF08515
(TGF_beta_GS) 		4 VAL A 218
ILE A 258
TYR A 281
ILE A 348
 LDN  A   1 ( 4.8A)
None
LDN  A   1 ( 4.8A)
None
 0.52A 4c8bA-3mdyA:
24.9		 4c8bA-3mdyA:
27.39
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3mn3 CARBON
CATABOLITE-DEREPRESS
ING PROTEIN KINASE

(Saccharomyces
cerevisiae) 		PF00069
(Pkinase) 		4 VAL A  69
ILE A 115
TYR A 134
ILE A 193
 None
 0.62A 4c8bA-3mn3A:
20.7		 4c8bA-3mn3A:
25.66
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3mt1 PUTATIVE
CARBOXYNORSPERMIDINE
DECARBOXYLASE
PROTEIN

(Sinorhizobium
meliloti) 		PF00278
(Orn_DAP_Arg_deC) 		4 VAL A 335
ILE A 316
MET A 267
ILE A 290
 None
 0.87A 4c8bA-3mt1A:
undetectable		 4c8bA-3mt1A:
20.35
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3my0 SERINE/THREONINE-PRO
TEIN KINASE RECEPTOR
R3

(Homo sapiens) 		PF07714
(Pkinase_Tyr) 		4 VAL A 216
ILE A 256
TYR A 279
ILE A 346
 LDN  A 600 (-4.5A)
None
LDN  A 600 (-4.7A)
None
 0.76A 4c8bA-3my0A:
23.9		 4c8bA-3my0A:
27.04
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3oz6 MITOGEN-ACTIVATED
PROTEIN KINASE 1,
SERINE/THREONINE
PROTEIN KINASE

(Cryptosporidium
parvum) 		PF00069
(Pkinase) 		4 VAL A  25
ILE A  71
TYR A  92
MET A  93
 None
 0.64A 4c8bA-3oz6A:
20.4		 4c8bA-3oz6A:
22.80
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3prh TRYPTOPHANYL-TRNA
SYNTHETASE

(Bacillus
subtilis) 		PF00579
(tRNA-synt_1b) 		4 VAL A  48
ILE A  80
TYR A 126
ILE A  40
 None
 0.90A 4c8bA-3prhA:
undetectable		 4c8bA-3prhA:
24.14
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3tt0 BASIC FIBROBLAST
GROWTH FACTOR
RECEPTOR 1

(Homo sapiens) 		PF07714
(Pkinase_Tyr) 		4 VAL A 492
ILE A 544
TYR A 563
ILE A 639
 07J  A   1 (-4.0A)
None
07J  A   1 (-4.7A)
None
 0.64A 4c8bA-3tt0A:
26.7		 4c8bA-3tt0A:
27.07
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3v5q NT-3 GROWTH FACTOR
RECEPTOR

(Homo sapiens) 		PF07714
(Pkinase_Tyr) 		5 VAL A 552
ILE A 600
TYR A 619
MET A 620
ILE A 695
 None
0F4  A 902 (-4.1A)
0F4  A 902 (-4.2A)
None
0F4  A 902 (-4.6A)
 0.43A 4c8bA-3v5qA:
26.5		 4c8bA-3v5qA:
29.30
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3w18 AURORA KINASE A

(Homo sapiens) 		PF00069
(Pkinase) 		4 VAL A 147
ILE A 193
TYR A 212
ILE A 272
 N13  A 501 ( 4.7A)
None
N13  A 501 (-4.4A)
None
 0.38A 4c8bA-3w18A:
23.5		 4c8bA-3w18A:
26.35
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3zbf PROTO-ONCOGENE
TYROSINE-PROTEIN
KINASE ROS

(Homo sapiens) 		PF07714
(Pkinase_Tyr) 		4 VAL A1959
ILE A2009
MET A2029
ILE A2100
 None
 0.65A 4c8bA-3zbfA:
27.1		 4c8bA-3zbfA:
31.92
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4af3 AURORA KINASE B

(Homo sapiens) 		PF00069
(Pkinase) 		4 VAL A  91
ILE A 137
TYR A 156
ILE A 216
 VX6  A 500 ( 4.8A)
None
VX6  A 500 (-4.2A)
None
 0.58A 4c8bA-4af3A:
20.4		 4c8bA-4af3A:
27.51
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4at3 BDNF/NT-3 GROWTH
FACTORS RECEPTOR

(Homo sapiens) 		PF07714
(Pkinase_Tyr) 		5 VAL A 568
ILE A 616
TYR A 635
MET A 636
ILE A 708
 None
None
LTI  A1839 (-4.7A)
None
None
 0.58A 4c8bA-4at3A:
26.6		 4c8bA-4at3A:
28.49
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4b99 MITOGEN-ACTIVATED
PROTEIN KINASE 7

(Homo sapiens) 		PF00069
(Pkinase) 		4 VAL A  69
ILE A 114
MET A 140
ILE A 198
 R4L  A1394 (-4.0A)
None
None
None
 0.55A 4c8bA-4b99A:
22.1		 4c8bA-4b99A:
24.14
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4c02 ACTIVIN RECEPTOR
TYPE-1

(Homo sapiens) 		PF00069
(Pkinase)
PF08515
(TGF_beta_GS) 		4 VAL A 222
ILE A 262
TYR A 285
ILE A 352
 TAK  A1507 (-4.7A)
None
TAK  A1507 ( 4.6A)
None
 0.76A 4c8bA-4c02A:
24.2		 4c8bA-4c02A:
27.91
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4cfh 5'-AMP-ACTIVATED
PROTEIN KINASE
CATALYTIC SUBUNIT
ALPHA-1

(Rattus
norvegicus) 		PF00069
(Pkinase)
PF16579
(AdenylateSensor) 		4 VAL A  30
ILE A  76
TYR A  95
ILE A 155
 None
None
STU  A1550 (-4.5A)
None
 0.46A 4c8bA-4cfhA:
23.4		 4c8bA-4cfhA:
26.46
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ckr EPITHELIAL DISCOIDIN
DOMAIN-CONTAINING
RECEPTOR 1

(Homo sapiens) 		PF07714
(Pkinase_Tyr) 		5 VAL A 624
ILE A 684
TYR A 703
MET A 704
ILE A 782
 DI1  A1000 (-4.8A)
DI1  A1000 ( 4.5A)
DI1  A1000 (-4.0A)
None
DI1  A1000 (-4.5A)
 0.65A 4c8bA-4ckrA:
25.8		 4c8bA-4ckrA:
26.40
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4d61 EUKARYOTIC PEPTIDE
CHAIN RELEASE FACTOR
GTP-BINDING SUBUNIT
ERF3A

(Homo sapiens) 		PF01201
(Ribosomal_S8e) 		4 VAL i 552
ILE i 558
TYR i 539
ILE i 583
 None
 0.92A 4c8bA-4d61i:
undetectable		 4c8bA-4d61i:
23.36
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4dpg LYSINE--TRNA LIGASE

(Homo sapiens) 		PF00152
(tRNA-synt_2)
PF01336
(tRNA_anti-codon) 		4 VAL A 358
ILE A 394
MET A 351
ILE A 462
 None
 0.64A 4c8bA-4dpgA:
undetectable		 4c8bA-4dpgA:
22.05
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4eqm PROTEIN KINASE

(Staphylococcus
aureus) 		PF00069
(Pkinase) 		4 VAL A  24
ILE A  70
TYR A  89
ILE A 149
 ANP  A 300 ( 4.7A)
None
ANP  A 300 (-4.3A)
None
 0.45A 4c8bA-4eqmA:
23.1		 4c8bA-4eqmA:
25.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4eqm PROTEIN KINASE

(Staphylococcus
aureus) 		PF00069
(Pkinase) 		4 VAL A  24
ILE A 149
TYR A  89
ILE A 139
 ANP  A 300 ( 4.7A)
None
ANP  A 300 (-4.3A)
None
 0.92A 4c8bA-4eqmA:
23.1		 4c8bA-4eqmA:
25.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4f0i HIGH AFFINITY NERVE
GROWTH FACTOR
RECEPTOR

(Homo sapiens) 		PF07714
(Pkinase_Tyr) 		5 VAL A 523
ILE A 571
TYR A 590
MET A 591
ILE A 665
 None
 0.48A 4c8bA-4f0iA:
26.4		 4c8bA-4f0iA:
28.17
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4f1r CATABOLITE
REPRESSION CONTROL
PROTEIN

(Pseudomonas
aeruginosa) 		PF03372
(Exo_endo_phos) 		4 VAL A 102
ILE A   4
TYR A 145
ILE A  31
 None
 0.87A 4c8bA-4f1rA:
undetectable		 4c8bA-4f1rA:
23.80
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4fod ALK TYROSINE KINASE
RECEPTOR

(Homo sapiens) 		PF07714
(Pkinase_Tyr) 		4 VAL A1130
ILE A1179
MET A1199
ILE A1268
 0UV  A1501 (-4.5A)
None
None
None
 0.52A 4c8bA-4fodA:
26.0		 4c8bA-4fodA:
27.45
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4gl9 TYROSINE-PROTEIN
KINASE

(Mus musculus) 		PF07714
(Pkinase_Tyr) 		4 VAL A 863
ILE A 910
TYR A 931
ILE A 992
 None
 0.63A 4c8bA-4gl9A:
25.1		 4c8bA-4gl9A:
28.18
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4hvi TYROSINE-PROTEIN
KINASE JAK3

(Homo sapiens) 		PF07714
(Pkinase_Tyr) 		4 VAL A 836
ILE A 883
TYR A 904
ILE A 965
 19S  A1201 (-4.4A)
None
19S  A1201 (-4.7A)
None
 0.60A 4c8bA-4hviA:
25.7		 4c8bA-4hviA:
29.86
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4j3o OUTER MEMBRANE USHER
PROTEIN FIMD

(Escherichia
coli) 		PF00577
(Usher)
PF13953
(PapC_C)
PF13954
(PapC_N) 		4 VAL D  35
ILE D 115
TYR D  43
MET D  44
 None
 0.93A 4c8bA-4j3oD:
undetectable		 4c8bA-4j3oD:
16.94
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4jg3 CATABOLITE
REPRESSION CONTROL
PROTEIN

(Pseudomonas
aeruginosa) 		PF03372
(Exo_endo_phos) 		4 VAL A 105
ILE A   7
TYR A 148
ILE A  34
 None
 0.86A 4c8bA-4jg3A:
undetectable		 4c8bA-4jg3A:
20.63
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4k33 FIBROBLAST GROWTH
FACTOR RECEPTOR 3

(Homo sapiens) 		PF07714
(Pkinase_Tyr) 		4 VAL A 486
ILE A 538
TYR A 557
ILE A 633
 ACP  A 801 (-4.2A)
None
None
None
 0.45A 4c8bA-4k33A:
26.5		 4c8bA-4k33A:
30.92
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4l52 MITOGEN-ACTIVATED
PROTEIN KINASE
KINASE KINASE 7,
TGF-BETA-ACTIVATED
KINASE 1 AND
MAP3K7-BINDING
PROTEIN 1 CHIMERA

(Homo sapiens) 		PF07714
(Pkinase_Tyr) 		4 VAL A  50
ILE A  89
TYR A 106
ILE A 173
 1UL  A 501 ( 4.9A)
None
1UL  A 501 (-4.1A)
None
 0.64A 4c8bA-4l52A:
28.9		 4c8bA-4l52A:
29.38
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4mk0 BETA-ADRENERGIC
RECEPTOR KINASE 1

(Homo sapiens) 		PF00069
(Pkinase)
PF00169
(PH)
PF00615
(RGS) 		4 VAL A 205
ILE A 254
MET A 274
ILE A 333
 29X  A 702 (-4.7A)
None
None
None
 0.77A 4c8bA-4mk0A:
13.2		 4c8bA-4mk0A:
19.39
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4oli NON-RECEPTOR
TYROSINE-PROTEIN
KINASE TYK2

(Homo sapiens) 		PF07714
(Pkinase_Tyr) 		4 VAL A 911
ILE A 959
TYR A 980
ILE A1039
 2TT  A1202 (-4.5A)
None
2TT  A1202 (-4.6A)
None
 0.68A 4c8bA-4oliA:
25.5		 4c8bA-4oliA:
21.09
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4qny MITOGEN ACTIVATED
PROTEIN KINASE,
PUTATIVE

(Leishmania
donovani) 		PF00069
(Pkinase) 		4 VAL A  35
ILE A  82
MET A 107
ILE A 165
 ANP  A 402 (-4.3A)
None
None
None
 0.45A 4c8bA-4qnyA:
22.0		 4c8bA-4qnyA:
24.63
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4qny MITOGEN ACTIVATED
PROTEIN KINASE,
PUTATIVE

(Leishmania
donovani) 		PF00069
(Pkinase) 		4 VAL A  35
ILE A 165
MET A 107
ILE A 155
 ANP  A 402 (-4.3A)
None
None
None
 0.92A 4c8bA-4qnyA:
22.0		 4c8bA-4qnyA:
24.63
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4red 5'-AMP-ACTIVATED
PROTEIN KINASE
CATALYTIC SUBUNIT
ALPHA-1

(Homo sapiens) 		PF00069
(Pkinase) 		4 VAL A  32
ILE A  78
TYR A  97
ILE A 157
 None
 0.67A 4c8bA-4redA:
18.3		 4c8bA-4redA:
30.31
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4rew 5'-AMP-ACTIVATED
PROTEIN KINASE
CATALYTIC SUBUNIT
ALPHA-1

(Homo sapiens) 		PF00069
(Pkinase)
PF16579
(AdenylateSensor) 		4 VAL A  32
ILE A  78
TYR A  97
ILE A 157
 STU  A 601 ( 4.8A)
None
STU  A 601 (-4.4A)
None
 0.49A 4c8bA-4rewA:
22.9		 4c8bA-4rewA:
21.65
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4rt7 RECEPTOR-TYPE
TYROSINE-PROTEIN
KINASE FLT3

(Homo sapiens) 		PF07714
(Pkinase_Tyr) 		4 VAL A 624
ILE A 674
TYR A 693
ILE A 827
 None
None
P30  A1001 (-4.1A)
P30  A1001 ( 4.8A)
 0.42A 4c8bA-4rt7A:
26.8		 4c8bA-4rt7A:
26.55
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4wbo RHODOPSIN KINASE

(Bos taurus) 		PF00069
(Pkinase)
PF00615
(RGS) 		4 VAL A 201
ILE A 247
MET A 267
ILE A 330
 None
 0.53A 4c8bA-4wboA:
16.4		 4c8bA-4wboA:
21.46
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4xhb SIALIDASE B

(Streptococcus
pneumoniae) 		PF02012
(BNR)
PF02973
(Sialidase)
PF13088
(BNR_2) 		4 VAL A 453
ILE A 275
TYR A 408
ILE A 326
 None
None
None
NHE  A 702 ( 4.8A)
 0.90A 4c8bA-4xhbA:
undetectable		 4c8bA-4xhbA:
17.17
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4xrl MITOGEN-ACTIVATED
PROTEIN KINASE 1

(Rattus
norvegicus) 		PF00069
(Pkinase) 		4 VAL A  37
ILE A  81
MET A 106
ILE A 163
 None
 0.69A 4c8bA-4xrlA:
22.1		 4c8bA-4xrlA:
27.32
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4xuf RECEPTOR-TYPE
TYROSINE-PROTEIN
KINASE FLT3

(Homo sapiens) 		PF07714
(Pkinase_Tyr) 		4 VAL A 624
ILE A 674
TYR A 693
ILE A 827
 P30  A1001 ( 4.8A)
P30  A1001 (-4.3A)
P30  A1001 ( 4.4A)
P30  A1001 (-4.7A)
 0.35A 4c8bA-4xufA:
26.3		 4c8bA-4xufA:
27.64
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ydq PROLINE--TRNA LIGASE

(Plasmodium
falciparum) 		PF00587
(tRNA-synt_2b)
PF03129
(HGTP_anticodon)
PF09180
(ProRS-C_1) 		4 VAL A 298
ILE A 276
TYR A 293
ILE A 270
 None
 0.85A 4c8bA-4ydqA:
undetectable		 4c8bA-4ydqA:
20.35
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5a46 FIBROBLAST GROWTH
FACTOR RECEPTOR 1
(FMS-RELATED
TYROSINE KINASE 2,
PFEIFFER SYNDROME),
ISOFORM CRA_B

(Homo sapiens) 		PF07714
(Pkinase_Tyr) 		4 VAL A 492
ILE A 544
TYR A 563
ILE A 639
 38O  A1769 (-4.5A)
None
38O  A1769 (-4.2A)
None
 0.64A 4c8bA-5a46A:
19.8		 4c8bA-5a46A:
25.31
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5awm STRESS-ACTIVATED
PROTEIN KINASE JNK

(Drosophila
melanogaster) 		PF00069
(Pkinase) 		4 VAL A  38
ILE A  83
MET A 109
ILE A 165
 ANP  A 401 (-4.5A)
None
None
None
 0.43A 4c8bA-5awmA:
20.2		 4c8bA-5awmA:
24.52
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ci6 MITOGEN-ACTIVATED
PROTEIN KINASE 6

(Arabidopsis
thaliana) 		PF00069
(Pkinase) 		4 VAL A  77
ILE A 122
MET A 147
ILE A 205
 None
 0.76A 4c8bA-5ci6A:
21.2		 4c8bA-5ci6A:
23.41
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ci7 SERINE/THREONINE-PRO
TEIN KINASE ULK1

(Homo sapiens) 		PF00069
(Pkinase) 		4 VAL A  30
ILE A  75
TYR A  94
ILE A 163
 51W  A 401 ( 4.3A)
None
51W  A 401 ( 3.4A)
None
 0.37A 4c8bA-5ci7A:
22.4		 4c8bA-5ci7A:
27.51
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5es1 MAP/MICROTUBULE
AFFINITY-REGULATING
KINASE 4

(Homo sapiens) 		PF00069
(Pkinase)
PF00627
(UBA) 		4 VAL A  70
ILE A 115
TYR A 134
ILE A 194
 5RC  A4000 (-4.6A)
None
5RC  A4000 (-4.5A)
None
 0.53A 4c8bA-5es1A:
23.1		 4c8bA-5es1A:
27.20
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5f1z NON-RECEPTOR
TYROSINE-PROTEIN
KINASE TYK2

(Homo sapiens) 		PF07714
(Pkinase_Tyr) 		4 VAL A 911
ILE A 959
TYR A 980
ILE A1039
 5U3  A1200 ( 4.4A)
None
5U3  A1200 (-4.5A)
None
 0.48A 4c8bA-5f1zA:
24.6		 4c8bA-5f1zA:
28.93
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5fml PA SUBUNIT OF
INFLUENZA B
POLYMERASE
PB2 SUBUNIT OF
INFLUENZA B
POLYMERASE

(Influenza B
virus) 		PF00603
(Flu_PA)
no annotation 		4 VAL B 121
ILE A 755
TYR B  77
ILE A 751
 MG  B1195 (-4.1A)
None
None
None
 0.90A 4c8bA-5fmlB:
undetectable		 4c8bA-5fmlB:
22.39
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5grn PLATELET-DERIVED
GROWTH FACTOR
RECEPTOR ALPHA

(Homo sapiens) 		PF07714
(Pkinase_Tyr) 		4 VAL A 607
ILE A 657
TYR A 676
ILE A 834
 748  A1001 ( 4.7A)
748  A1001 ( 4.4A)
748  A1001 (-4.0A)
748  A1001 (-4.8A)
 0.41A 4c8bA-5grnA:
19.7		 4c8bA-5grnA:
27.37
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5hes MITOGEN-ACTIVATED
PROTEIN KINASE
KINASE KINASE MLT

(Homo sapiens) 		PF07714
(Pkinase_Tyr) 		4 VAL A  30
ILE A  65
TYR A  84
ILE A 149
 032  A 401 (-4.4A)
None
032  A 401 (-4.2A)
None
 0.61A 4c8bA-5hesA:
26.1		 4c8bA-5hesA:
31.05
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5hx6 RECEPTOR-INTERACTING
SERINE/THREONINE-PRO
TEIN KINASE 1

(Homo sapiens) 		PF07714
(Pkinase_Tyr) 		4 ILE A 154
TYR A  94
MET A  95
ILE A 144
 65U  A 301 (-4.1A)
None
None
None
 0.88A 4c8bA-5hx6A:
26.7		 4c8bA-5hx6A:
32.67
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5hxb EUKARYOTIC PEPTIDE
CHAIN RELEASE FACTOR
GTP-BINDING SUBUNIT
ERF3A

(Homo sapiens) 		no annotation 4 VAL X 561
ILE X 567
TYR X 548
ILE X 592
 None
 0.80A 4c8bA-5hxbX:
undetectable		 4c8bA-5hxbX:
21.47
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ig1 CAMK/CAMK2 PROTEIN
KINASE

(Salpingoeca
rosetta) 		PF00069
(Pkinase) 		4 VAL A  32
ILE A  77
TYR A  96
ILE A 159
 None
None
PO4  A 401 (-4.8A)
None
 0.57A 4c8bA-5ig1A:
24.1		 4c8bA-5ig1A:
23.92
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5iso 5'-AMP-ACTIVATED
PROTEIN KINASE
CATALYTIC SUBUNIT
ALPHA-2

(Homo sapiens) 		PF00069
(Pkinase)
PF16579
(AdenylateSensor) 		4 VAL A  30
ILE A  76
TYR A  95
ILE A 155
 STU  A 601 (-4.8A)
None
STU  A 601 (-4.3A)
None
 0.70A 4c8bA-5isoA:
23.4		 4c8bA-5isoA:
22.66
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5o2c SERINE/THREONINE-PRO
TEIN KINASE WNK3

(Homo sapiens) 		PF00069
(Pkinase)
PF12202
(OSR1_C) 		4 VAL A 161
ILE A 206
MET A 230
ILE A 292
 None
 0.34A 4c8bA-5o2cA:
23.8		 4c8bA-5o2cA:
27.88
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5o2c SERINE/THREONINE-PRO
TEIN KINASE WNK3

(Homo sapiens) 		PF00069
(Pkinase)
PF12202
(OSR1_C) 		4 VAL A 161
ILE A 292
MET A 230
ILE A 281
 None
 0.94A 4c8bA-5o2cA:
23.8		 4c8bA-5o2cA:
27.88
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5uuu BETA-ADRENERGIC
RECEPTOR KINASE 1

(Homo sapiens) 		PF00069
(Pkinase)
PF00615
(RGS) 		4 VAL A 205
ILE A 254
MET A 274
ILE A 333
 QRW  A 601 (-4.7A)
None
MES  A 604 (-3.9A)
None
 0.62A 4c8bA-5uuuA:
21.9		 4c8bA-5uuuA:
22.38
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5w5j RECEPTOR-INTERACTING
SERINE/THREONINE-PRO
TEIN KINASE 2

(Homo sapiens) 		no annotation 5 VAL A  32
ILE A  78
TYR A  97
MET A  98
ILE A 162
 9WS  A 401 ( 4.6A)
None
None
None
None
 0.39A 4c8bA-5w5jA:
35.5		 4c8bA-5w5jA:
92.99
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5w5j RECEPTOR-INTERACTING
SERINE/THREONINE-PRO
TEIN KINASE 2

(Homo sapiens) 		no annotation 5 VAL A  32
ILE A 162
TYR A  97
MET A  98
ILE A 152
 9WS  A 401 ( 4.6A)
None
None
None
None
 1.13A 4c8bA-5w5jA:
35.5		 4c8bA-5w5jA:
92.99
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5wnm RECEPTOR-INTERACTING
SERINE/THREONINE-PRO
TEIN KINASE 4

(Mus musculus) 		no annotation 5 VAL A  36
ILE A  81
TYR A  98
MET A  99
ILE A 159
 VX6  A 402 (-4.6A)
None
VX6  A 402 (-4.3A)
None
None
 0.32A 4c8bA-5wnmA:
31.2		 4c8bA-5wnmA:
12.73
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5wnm RECEPTOR-INTERACTING
SERINE/THREONINE-PRO
TEIN KINASE 4

(Mus musculus) 		no annotation 5 VAL A  36
ILE A 159
TYR A  98
MET A  99
ILE A 149
 VX6  A 402 (-4.6A)
None
VX6  A 402 (-4.3A)
None
None
 1.09A 4c8bA-5wnmA:
31.2		 4c8bA-5wnmA:
12.73
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5wrt SOLUBLE INORGANIC
PYROPHOSPHATASE

(Toxoplasma
gondii) 		no annotation 4 VAL A 294
ILE A 199
MET A 122
ILE A 233
 None
 0.85A 4c8bA-5wrtA:
undetectable		 4c8bA-5wrtA:
19.35
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6bx6 5'-AMP-ACTIVATED
PROTEIN KINASE
CATALYTIC SUBUNIT
ALPHA-2

(Homo sapiens) 		no annotation 4 VAL A  30
ILE A  76
TYR A  95
ILE A 155
 None
None
EDJ  A 301 ( 4.8A)
None
 0.71A 4c8bA-6bx6A:
19.9		 4c8bA-6bx6A:
13.31
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6c9d SERINE/THREONINE-PRO
TEIN KINASE
MARK1,SERINE/THREONI
NE-PROTEIN KINASE
MARK1

(Homo sapiens) 		no annotation 4 VAL A  74
ILE A 119
TYR A 138
ILE A 198
 None
 0.49A 4c8bA-6c9dA:
22.1		 4c8bA-6c9dA:
11.68
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6chd LYSINE--TRNA LIGASE

(Homo sapiens) 		no annotation 4 VAL A 358
ILE A 394
MET A 351
ILE A 462
 None
 0.68A 4c8bA-6chdA:
undetectable		 4c8bA-6chdA:
12.35
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6f3d INTERLEUKIN-1
RECEPTOR-ASSOCIATED
KINASE 4

(Homo sapiens) 		no annotation 5 VAL A 200
ILE A 327
TYR A 264
MET A 265
ILE A 317
 CJT  A 502 ( 4.8A)
None
CJT  A 502 (-4.5A)
CJT  A 502 (-4.9A)
None
 1.10A 4c8bA-6f3dA:
8.9		 4c8bA-6f3dA:
12.28