SIMILAR PATTERNS OF AMINO ACIDS FOR 4C8B_A_0LIA1000_1

List of similar pattern of amino acids derived from ASSAM search

Hit pattern: 3D amino acid arrangements similar to known drug binding site

Query pattern: Residues from known binding site for annotated drug that match the hit pattern


(Click link on the last column to view superposed patterns of amino acids in NGL viewer)
(Note that only 3-12 residue patterns can be used for ASSAM searches)
Filter list by:
Hit Macromolecule/
Organism
Pfam Res. Interface HETATM RMSD Dali Z-score Seq. Identity (%) View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1h4l CELL DIVISION
PROTEIN KINASE 5


(Homo sapiens)
PF00069
(Pkinase)
7 ALA A  31
LYS A  33
GLU A  51
LEU A  55
HIS A 124
LEU A 133
ALA A 143
None
0.81A 4c8bA-1h4lA:
22.3
4c8bA-1h4lA:
24.86
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1k9a CARBOXYL-TERMINAL
SRC KINASE


(Rattus
norvegicus)
PF00017
(SH2)
PF00018
(SH3_1)
PF07714
(Pkinase_Tyr)
7 ALA A 220
LYS A 222
GLU A 236
ILE A 264
THR A 266
HIS A 312
LEU A 321
None
0.51A 4c8bA-1k9aA:
26.7
4c8bA-1k9aA:
22.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1opk PROTO-ONCOGENE
TYROSINE-PROTEIN
KINASE ABL1


(Mus musculus)
PF00017
(SH2)
PF00018
(SH3_1)
PF07714
(Pkinase_Tyr)
8 ALA A 288
LYS A 290
GLU A 305
ILE A 332
THR A 334
HIS A 380
LEU A 389
ALA A 399
P16  A   2 (-3.4A)
P16  A   2 (-4.5A)
P16  A   2 (-4.2A)
P16  A   2 (-4.1A)
P16  A   2 (-3.7A)
None
P16  A   2 (-4.4A)
P16  A   2 (-3.5A)
0.50A 4c8bA-1opkA:
25.4
4c8bA-1opkA:
20.68
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1py5 TGF-BETA RECEPTOR
TYPE I


(Homo sapiens)
PF00069
(Pkinase)
PF08515
(TGF_beta_GS)
7 ALA A 230
LYS A 232
GLU A 245
LEU A 260
HIS A 331
LEU A 340
ALA A 350
PY1  A 700 (-3.5A)
PY1  A 700 (-3.9A)
PY1  A 700 ( 4.9A)
PY1  A 700 (-4.2A)
None
PY1  A 700 (-4.4A)
PY1  A 700 ( 4.2A)
0.48A 4c8bA-1py5A:
18.5
4c8bA-1py5A:
26.18
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1q8y SR PROTEIN KINASE

(Saccharomyces
cerevisiae)
PF00069
(Pkinase)
8 ALA A 185
GLU A 202
LEU A 206
LEU A 226
HIS A 292
LEU A 301
ALA A 549
ASP A 550
ADP  A 810 (-3.3A)
None
None
ADP  A 810 (-4.4A)
None
ADP  A 810 (-4.7A)
None
ADP  A 810 ( 3.0A)
1.04A 4c8bA-1q8yA:
21.2
4c8bA-1q8yA:
23.76
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1q8y SR PROTEIN KINASE

(Saccharomyces
cerevisiae)
PF00069
(Pkinase)
8 ALA A 185
LYS A 187
GLU A 202
LEU A 206
LEU A 226
HIS A 292
LEU A 301
ALA A 549
ADP  A 810 (-3.3A)
ADP  A 810 (-3.1A)
None
None
ADP  A 810 (-4.4A)
None
ADP  A 810 (-4.7A)
None
0.73A 4c8bA-1q8yA:
21.2
4c8bA-1q8yA:
23.76
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1t46 HOMO SAPIENS V-KIT
HARDY-ZUCKERMAN 4
FELINE SARCOMA VIRAL
ONCOGENE HOMOLOG


(Homo sapiens)
PF07714
(Pkinase_Tyr)
7 ALA A 621
LYS A 623
GLU A 640
HIS A 790
LEU A 799
ASP A 810
PHE A 811
STI  A   3 (-3.5A)
STI  A   3 (-3.7A)
STI  A   3 (-3.6A)
STI  A   3 (-4.5A)
STI  A   3 (-4.4A)
STI  A   3 (-3.9A)
STI  A   3 (-3.6A)
0.77A 4c8bA-1t46A:
27.3
4c8bA-1t46A:
26.68
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1t46 HOMO SAPIENS V-KIT
HARDY-ZUCKERMAN 4
FELINE SARCOMA VIRAL
ONCOGENE HOMOLOG


(Homo sapiens)
PF07714
(Pkinase_Tyr)
8 ALA A 621
LYS A 623
GLU A 640
LEU A 644
THR A 670
HIS A 790
LEU A 799
ASP A 810
STI  A   3 (-3.5A)
STI  A   3 (-3.7A)
STI  A   3 (-3.6A)
STI  A   3 (-4.4A)
STI  A   3 (-3.2A)
STI  A   3 (-4.5A)
STI  A   3 (-4.4A)
STI  A   3 (-3.9A)
0.46A 4c8bA-1t46A:
27.3
4c8bA-1t46A:
26.68
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2buj SERINE/THREONINE-PRO
TEIN KINASE 16


(Homo sapiens)
PF00069
(Pkinase)
7 ALA A  47
LYS A  49
GLU A  65
LEU A  78
HIS A 146
LEU A 155
ASP A 166
STU  A1301 (-3.6A)
STU  A1301 ( 4.0A)
None
None
None
STU  A1301 ( 4.8A)
None
0.92A 4c8bA-2bujA:
24.2
4c8bA-2bujA:
26.54
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2dq7 PROTO-ONCOGENE
TYROSINE-PROTEIN
KINASE FYN


(Homo sapiens)
PF07714
(Pkinase_Tyr)
8 ALA X  37
LYS X  39
GLU X  54
ILE X  80
THR X  82
HIS X 128
LEU X 137
ALA X 147
STU  X 902 (-3.1A)
STU  X 902 (-3.1A)
STU  X 902 ( 4.4A)
None
STU  X 902 (-4.1A)
None
STU  X 902 (-4.4A)
STU  X 902 ( 4.1A)
0.64A 4c8bA-2dq7X:
26.6
4c8bA-2dq7X:
26.11
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2eu9 DUAL SPECIFICITY
PROTEIN KINASE CLK3


(Homo sapiens)
PF00069
(Pkinase)
7 ALA A 184
LYS A 186
GLU A 201
ILE A 234
HIS A 281
LEU A 290
ALA A 319
None
0.57A 4c8bA-2eu9A:
21.9
4c8bA-2eu9A:
24.82
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2eu9 DUAL SPECIFICITY
PROTEIN KINASE CLK3


(Homo sapiens)
PF00069
(Pkinase)
7 ALA A 184
LYS A 186
GLU A 201
LEU A 205
ILE A 234
HIS A 281
ALA A 319
None
0.68A 4c8bA-2eu9A:
21.9
4c8bA-2eu9A:
24.82
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2eu9 DUAL SPECIFICITY
PROTEIN KINASE CLK3


(Homo sapiens)
PF00069
(Pkinase)
7 LYS A 186
GLU A 201
ILE A 234
HIS A 281
LEU A 290
ALA A 319
ASP A 320
None
1.13A 4c8bA-2eu9A:
21.9
4c8bA-2eu9A:
24.82
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2eu9 DUAL SPECIFICITY
PROTEIN KINASE CLK3


(Homo sapiens)
PF00069
(Pkinase)
7 LYS A 186
GLU A 201
LEU A 205
ILE A 234
HIS A 281
ALA A 319
ASP A 320
None
1.10A 4c8bA-2eu9A:
21.9
4c8bA-2eu9A:
24.82
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2f9g MITOGEN-ACTIVATED
PROTEIN KINASE FUS3


(Saccharomyces
cerevisiae)
PF00069
(Pkinase)
7 ALA A  40
LYS A  42
GLU A  59
LEU A  63
ILE A  91
HIS A 135
LEU A 144
ADP  A 500 ( 3.7A)
ADP  A 500 (-2.9A)
None
None
None
None
ADP  A 500 (-4.3A)
0.77A 4c8bA-2f9gA:
13.7
4c8bA-2f9gA:
25.13
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2hck HEMATOPOETIC CELL
KINASE HCK


(Homo sapiens)
PF00017
(SH2)
PF00018
(SH3_1)
PF07714
(Pkinase_Tyr)
7 ALA A 293
LYS A 295
ILE A 336
THR A 338
HIS A 384
LEU A 393
ALA A 403
QUE  A   1 (-3.5A)
None
None
QUE  A   1 (-3.3A)
None
QUE  A   1 (-4.4A)
QUE  A   1 ( 4.5A)
0.91A 4c8bA-2hckA:
25.6
4c8bA-2hckA:
22.38
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2hen EPHRIN TYPE-B
RECEPTOR 2


(Mus musculus)
PF07714
(Pkinase_Tyr)
7 ALA A 659
LYS A 661
GLU A 678
ILE A 705
THR A 707
HIS A 752
ASP A 772
ADP  A 400 (-3.2A)
ADP  A 400 (-2.7A)
ADP  A 400 ( 4.9A)
None
ADP  A 400 (-4.7A)
None
ADP  A 400 ( 4.8A)
0.93A 4c8bA-2henA:
27.4
4c8bA-2henA:
25.66
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2hk5 TYROSINE-PROTEIN
KINASE HCK


(Homo sapiens)
PF07714
(Pkinase_Tyr)
8 ALA A 271
LYS A 273
GLU A 288
ILE A 314
THR A 316
HIS A 362
LEU A 371
ALA A 381
1BM  A 499 (-3.6A)
1BM  A 499 (-3.8A)
1BM  A 499 (-3.2A)
1BM  A 499 (-3.9A)
1BM  A 499 (-3.2A)
None
1BM  A 499 (-4.4A)
1BM  A 499 ( 3.7A)
0.78A 4c8bA-2hk5A:
26.4
4c8bA-2hk5A:
25.36
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2hk5 TYROSINE-PROTEIN
KINASE HCK


(Homo sapiens)
PF07714
(Pkinase_Tyr)
7 ALA A 271
LYS A 273
ILE A 314
THR A 316
LEU A 371
ALA A 381
ASP A 382
1BM  A 499 (-3.6A)
1BM  A 499 (-3.8A)
1BM  A 499 (-3.9A)
1BM  A 499 (-3.2A)
1BM  A 499 (-4.4A)
1BM  A 499 ( 3.7A)
1BM  A 499 (-4.4A)
0.66A 4c8bA-2hk5A:
26.4
4c8bA-2hk5A:
25.36
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2hz0 PROTO-ONCOGENE
TYROSINE-PROTEIN
KINASE ABL1


(Homo sapiens)
PF07714
(Pkinase_Tyr)
9 ALA A 269
LYS A 271
GLU A 286
ILE A 313
THR A 315
HIS A 361
LEU A 370
ALA A 380
ASP A 381
GIN  A 600 (-3.1A)
GIN  A 600 (-3.6A)
GIN  A 600 (-3.6A)
GIN  A 600 (-3.8A)
GIN  A 600 (-3.4A)
GIN  A 600 (-4.3A)
GIN  A 600 (-4.7A)
GIN  A 600 (-3.1A)
GIN  A 600 (-4.9A)
0.77A 4c8bA-2hz0A:
26.4
4c8bA-2hz0A:
26.30
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2j0j FOCAL ADHESION
KINASE 1


(Gallus gallus)
PF00373
(FERM_M)
PF07714
(Pkinase_Tyr)
7 ALA A 452
LYS A 454
GLU A 471
ILE A 497
HIS A 544
LEU A 553
ASP A 564
4ST  A1687 (-3.3A)
4ST  A1687 (-3.4A)
4ST  A1687 ( 4.6A)
None
None
4ST  A1687 (-4.4A)
4ST  A1687 (-4.7A)
0.77A 4c8bA-2j0jA:
27.3
4c8bA-2j0jA:
19.83
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2jkm FOCAL ADHESION
KINASE 1


(Gallus gallus)
PF07714
(Pkinase_Tyr)
7 ALA A 452
LYS A 454
GLU A 471
ILE A 497
HIS A 544
LEU A 553
ASP A 564
BII  A1687 (-3.5A)
BII  A1687 (-2.9A)
None
None
None
BII  A1687 (-4.2A)
None
0.89A 4c8bA-2jkmA:
27.1
4c8bA-2jkmA:
26.67
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2og8 PROTO-ONCOGENE
TYROSINE-PROTEIN
KINASE LCK


(Homo sapiens)
PF07714
(Pkinase_Tyr)
9 ALA A 271
LYS A 273
GLU A 288
ILE A 314
THR A 316
HIS A 362
LEU A 371
ALA A 381
ASP A 382
1N8  A 501 ( 3.4A)
1N8  A 501 ( 3.4A)
1N8  A 501 ( 3.6A)
1N8  A 501 ( 4.6A)
1N8  A 501 ( 3.3A)
None
1N8  A 501 ( 4.3A)
1N8  A 501 ( 3.3A)
1N8  A 501 ( 3.3A)
0.55A 4c8bA-2og8A:
27.1
4c8bA-2og8A:
26.61
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2og8 PROTO-ONCOGENE
TYROSINE-PROTEIN
KINASE LCK


(Homo sapiens)
PF07714
(Pkinase_Tyr)
9 ALA A 271
LYS A 273
GLU A 288
THR A 316
HIS A 362
LEU A 371
ALA A 381
ASP A 382
PHE A 383
1N8  A 501 ( 3.4A)
1N8  A 501 ( 3.4A)
1N8  A 501 ( 3.6A)
1N8  A 501 ( 3.3A)
None
1N8  A 501 ( 4.3A)
1N8  A 501 ( 3.3A)
1N8  A 501 ( 3.3A)
1N8  A 501 ( 4.3A)
0.64A 4c8bA-2og8A:
27.1
4c8bA-2og8A:
26.61
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2ogv MACROPHAGE
COLONY-STIMULATING
FACTOR 1 RECEPTOR
PRECURSOR


(Homo sapiens)
PF07714
(Pkinase_Tyr)
7 ALA A 614
LYS A 616
GLU A 633
THR A 663
HIS A 776
LEU A 785
ASP A 796
None
0.78A 4c8bA-2ogvA:
25.9
4c8bA-2ogvA:
26.14
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2qlu ACTIVIN RECEPTOR
TYPE IIB


(Homo sapiens)
PF00069
(Pkinase)
7 ALA A 215
LYS A 217
LEU A 245
THR A 265
HIS A 319
LEU A 328
ALA A 338
ADE  A 488 (-3.2A)
None
ADE  A 488 ( 4.5A)
ADE  A 488 (-4.3A)
None
ADE  A 488 (-4.4A)
None
0.41A 4c8bA-2qluA:
24.6
4c8bA-2qluA:
27.91
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2qob EPHRIN RECEPTOR

(Homo sapiens)
PF07714
(Pkinase_Tyr)
7 ALA A 651
LYS A 653
GLU A 670
ILE A 697
THR A 699
HIS A 744
ASP A 764
PTR  A 701 ( 4.7A)
None
None
None
None
None
None
1.18A 4c8bA-2qobA:
27.4
4c8bA-2qobA:
26.61
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2qob EPHRIN RECEPTOR

(Homo sapiens)
PF07714
(Pkinase_Tyr)
7 ALA A 651
LYS A 653
ILE A 697
THR A 699
HIS A 744
LEU A 753
ASP A 764
PTR  A 701 ( 4.7A)
None
None
None
None
None
None
0.92A 4c8bA-2qobA:
27.4
4c8bA-2qobA:
26.61
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2v55 RHO-ASSOCIATED
PROTEIN KINASE 1


(Homo sapiens)
PF00069
(Pkinase)
7 ALA A 103
LYS A 105
GLU A 124
HIS A 196
LEU A 205
ALA A 215
ASP A 216
ANP  A1480 ( 3.9A)
ANP  A1480 (-3.4A)
None
None
ANP  A1480 ( 4.7A)
ANP  A1480 ( 4.1A)
ANP  A1480 (-3.5A)
1.12A 4c8bA-2v55A:
20.4
4c8bA-2v55A:
24.53
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2vd5 DMPK PROTEIN

(Homo sapiens)
PF00069
(Pkinase)
7 ALA A  98
GLU A 119
LEU A 123
HIS A 193
LEU A 202
ALA A 212
ASP A 213
BI8  A1417 ( 3.8A)
BI8  A1417 ( 4.9A)
None
None
BI8  A1417 (-4.8A)
BI8  A1417 ( 4.1A)
BI8  A1417 (-3.8A)
1.05A 4c8bA-2vd5A:
21.4
4c8bA-2vd5A:
23.90
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2xik SERINE/THREONINE
PROTEIN KINASE 25


(Homo sapiens)
PF00069
(Pkinase)
7 ALA A  47
GLU A  66
LEU A  70
ILE A  93
HIS A 138
LEU A 147
ALA A 157
J60  A1294 (-3.3A)
None
None
None
None
J60  A1294 (-4.8A)
J60  A1294 ( 4.2A)
0.67A 4c8bA-2xikA:
17.9
4c8bA-2xikA:
26.79
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2xik SERINE/THREONINE
PROTEIN KINASE 25


(Homo sapiens)
PF00069
(Pkinase)
7 ALA A  47
LYS A  49
GLU A  66
LEU A  70
ILE A  93
HIS A 138
LEU A 147
J60  A1294 (-3.3A)
None
None
None
None
None
J60  A1294 (-4.8A)
0.91A 4c8bA-2xikA:
17.9
4c8bA-2xikA:
26.79
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2xyu EPHRIN TYPE-A
RECEPTOR 4,


(Mus musculus)
PF07714
(Pkinase_Tyr)
7 ALA A 651
LYS A 653
ILE A 697
THR A 699
HIS A 744
LEU A 753
ASP A 764
Q9G  A1898 (-3.2A)
Q9G  A1898 (-4.8A)
Q9G  A1898 ( 4.6A)
Q9G  A1898 (-3.5A)
None
Q9G  A1898 (-4.3A)
None
0.83A 4c8bA-2xyuA:
27.9
4c8bA-2xyuA:
28.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2zv7 TYROSINE-PROTEIN
KINASE LYN


(Mus musculus)
PF07714
(Pkinase_Tyr)
7 ALA A 273
LYS A 275
GLU A 290
ILE A 317
THR A 319
HIS A 365
ASP A 385
None
1.01A 4c8bA-2zv7A:
26.9
4c8bA-2zv7A:
26.71
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2zv7 TYROSINE-PROTEIN
KINASE LYN


(Mus musculus)
PF07714
(Pkinase_Tyr)
8 ALA A 273
LYS A 275
ILE A 317
THR A 319
HIS A 365
LEU A 374
ALA A 384
ASP A 385
None
0.81A 4c8bA-2zv7A:
26.9
4c8bA-2zv7A:
26.71
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3d7u TYROSINE-PROTEIN
KINASE CSK


(Homo sapiens)
PF07714
(Pkinase_Tyr)
7 ALA A 220
LYS A 222
GLU A 236
ILE A 264
THR A 266
HIS A 312
LEU A 321
None
0.51A 4c8bA-3d7uA:
20.8
4c8bA-3d7uA:
27.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3dko EPHRIN TYPE-A
RECEPTOR 7


(Homo sapiens)
PF07714
(Pkinase_Tyr)
PF14575
(EphA2_TM)
7 ALA A 663
GLU A 682
ILE A 709
HIS A 756
LEU A 765
ASP A 776
PHE A 777
IHZ  A1001 (-3.3A)
IHZ  A1001 (-3.8A)
None
IHZ  A1001 ( 4.9A)
IHZ  A1001 (-4.6A)
IHZ  A1001 (-4.8A)
IHZ  A1001 (-4.7A)
0.69A 4c8bA-3dkoA:
26.9
4c8bA-3dkoA:
26.16
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3gp0 MITOGEN-ACTIVATED
PROTEIN KINASE 11


(Homo sapiens)
PF00069
(Pkinase)
7 ALA A  51
LYS A  53
GLU A  71
LEU A  75
THR A 106
HIS A 148
ASP A 168
NIL  A   1 (-3.7A)
None
NIL  A   1 (-3.7A)
NIL  A   1 ( 4.8A)
NIL  A   1 (-3.3A)
NIL  A   1 (-4.3A)
NIL  A   1 (-4.6A)
0.77A 4c8bA-3gp0A:
21.8
4c8bA-3gp0A:
25.46
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3hng VASCULAR ENDOTHELIAL
GROWTH FACTOR
RECEPTOR 1


(Homo sapiens)
PF07714
(Pkinase_Tyr)
7 ALA A 859
LYS A 861
GLU A 878
HIS A1020
LEU A1029
ASP A1040
PHE A1041
8ST  A2001 ( 3.8A)
8ST  A2001 (-4.0A)
8ST  A2001 (-3.7A)
8ST  A2001 ( 4.8A)
None
None
8ST  A2001 ( 3.7A)
0.79A 4c8bA-3hngA:
26.3
4c8bA-3hngA:
24.57
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3hng VASCULAR ENDOTHELIAL
GROWTH FACTOR
RECEPTOR 1


(Homo sapiens)
PF07714
(Pkinase_Tyr)
7 ALA A 859
LYS A 861
GLU A 878
LEU A 882
HIS A1020
LEU A1029
ASP A1040
8ST  A2001 ( 3.8A)
8ST  A2001 (-4.0A)
8ST  A2001 (-3.7A)
None
8ST  A2001 ( 4.8A)
None
None
0.71A 4c8bA-3hngA:
26.3
4c8bA-3hngA:
24.57
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3kul EPHRIN TYPE-A
RECEPTOR 8


(Homo sapiens)
PF07714
(Pkinase_Tyr)
PF14575
(EphA2_TM)
7 ALA A 665
LYS A 667
GLU A 684
ILE A 711
THR A 713
HIS A 758
LEU A 767
None
0.49A 4c8bA-3kulA:
27.6
4c8bA-3kulA:
31.11
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3lj0 SERINE/THREONINE-PRO
TEIN
KINASE/ENDORIBONUCLE
ASE IRE1


(Saccharomyces
cerevisiae)
PF00069
(Pkinase)
PF06479
(Ribonuc_2-5A)
7 ALA A 700
GLU A 715
LEU A 719
ILE A 743
HIS A 795
LEU A 804
ASP A 828
ADP  A2101 (-3.5A)
None
None
None
None
ADP  A2101 (-4.4A)
SR  A2103 (-2.6A)
1.09A 4c8bA-3lj0A:
22.8
4c8bA-3lj0A:
27.03
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3lj0 SERINE/THREONINE-PRO
TEIN
KINASE/ENDORIBONUCLE
ASE IRE1


(Saccharomyces
cerevisiae)
PF00069
(Pkinase)
PF06479
(Ribonuc_2-5A)
7 ALA A 700
LYS A 702
GLU A 715
LEU A 719
ILE A 743
HIS A 795
LEU A 804
ADP  A2101 (-3.5A)
ADP  A2101 (-2.7A)
None
None
None
None
ADP  A2101 (-4.4A)
0.66A 4c8bA-3lj0A:
22.8
4c8bA-3lj0A:
27.03
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3llt SERINE/THREONINE
KINASE-1, PFLAMMER


(Plasmodium
falciparum)
PF00069
(Pkinase)
7 ALA A 579
LYS A 581
GLU A 596
LEU A 600
HIS A 675
LEU A 684
ASP A 720
ANP  A 877 ( 3.7A)
ANP  A 877 (-2.7A)
ANP  A 877 ( 4.4A)
None
None
None
ANP  A 877 (-2.9A)
1.07A 4c8bA-3lltA:
21.0
4c8bA-3lltA:
28.24
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3mdy BONE MORPHOGENETIC
PROTEIN RECEPTOR
TYPE-1B


(Homo sapiens)
PF07714
(Pkinase_Tyr)
PF08515
(TGF_beta_GS)
8 ALA A 229
LYS A 231
GLU A 244
LEU A 259
THR A 279
HIS A 330
LEU A 339
ALA A 349
LDN  A   1 (-3.6A)
None
None
None
LDN  A   1 (-3.8A)
None
LDN  A   1 (-4.5A)
LDN  A   1 ( 3.8A)
0.70A 4c8bA-3mdyA:
24.9
4c8bA-3mdyA:
27.39
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3mi9 CELL DIVISION
PROTEIN KINASE 9


(Homo sapiens)
PF00069
(Pkinase)
7 ALA A  46
LYS A  48
GLU A  66
LEU A  70
HIS A 147
LEU A 156
ALA A 166
None
0.68A 4c8bA-3mi9A:
23.3
4c8bA-3mi9A:
24.37
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3my0 SERINE/THREONINE-PRO
TEIN KINASE RECEPTOR
R3


(Homo sapiens)
PF07714
(Pkinase_Tyr)
7 ALA A 227
LEU A 257
THR A 277
HIS A 328
LEU A 337
ALA A 347
ASP A 348
LDN  A 600 (-3.2A)
None
LDN  A 600 (-4.0A)
None
LDN  A 600 (-4.6A)
LDN  A 600 ( 3.8A)
None
0.66A 4c8bA-3my0A:
23.9
4c8bA-3my0A:
27.04
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3my0 SERINE/THREONINE-PRO
TEIN KINASE RECEPTOR
R3


(Homo sapiens)
PF07714
(Pkinase_Tyr)
7 ALA A 227
LYS A 229
LEU A 257
THR A 277
HIS A 328
LEU A 337
ALA A 347
LDN  A 600 (-3.2A)
LDN  A 600 (-4.0A)
None
LDN  A 600 (-4.0A)
None
LDN  A 600 (-4.6A)
LDN  A 600 ( 3.8A)
0.55A 4c8bA-3my0A:
23.9
4c8bA-3my0A:
27.04
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3n9x PHOSPHOTRANSFERASE

(Plasmodium
berghei)
PF00069
(Pkinase)
7 ALA A  55
LYS A  57
GLU A  75
LEU A  79
ILE A 107
HIS A 152
LEU A 161
GOL  A 434 ( 4.1A)
GOL  A 433 (-3.2A)
GOL  A 433 ( 4.8A)
None
None
None
GOL  A 434 (-4.2A)
0.85A 4c8bA-3n9xA:
20.3
4c8bA-3n9xA:
28.04
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3nie MAP2 KINASE

(Plasmodium
falciparum)
PF00069
(Pkinase)
7 ALA A  57
GLU A  77
LEU A  81
ILE A 109
HIS A 154
LEU A 163
ASP A 174
ANP  A 430 (-3.5A)
ANP  A 430 ( 4.4A)
None
None
None
ANP  A 430 (-4.4A)
ANP  A 430 (-2.8A)
1.01A 4c8bA-3nieA:
20.8
4c8bA-3nieA:
27.78
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3nie MAP2 KINASE

(Plasmodium
falciparum)
PF00069
(Pkinase)
7 ALA A  57
LYS A  59
GLU A  77
LEU A  81
ILE A 109
HIS A 154
LEU A 163
ANP  A 430 (-3.5A)
ANP  A 430 (-2.5A)
ANP  A 430 ( 4.4A)
None
None
None
ANP  A 430 (-4.4A)
0.77A 4c8bA-3nieA:
20.8
4c8bA-3nieA:
27.78
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3niz RHODANESE FAMILY
PROTEIN


(Cryptosporidium
parvum)
PF00069
(Pkinase)
7 ALA A  49
LYS A  51
GLU A  69
LEU A  73
HIS A 142
LEU A 151
ALA A 161
ADP  A 314 (-3.5A)
ADP  A 314 (-2.8A)
None
None
None
ADP  A 314 (-4.6A)
None
0.70A 4c8bA-3nizA:
23.6
4c8bA-3nizA:
28.82
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3ppz SERINE/THREONINE-PRO
TEIN KINASE CTR1


(Arabidopsis
thaliana)
PF07714
(Pkinase_Tyr)
7 ALA A 576
LYS A 578
GLU A 596
ILE A 623
THR A 625
HIS A 674
LEU A 683
STU  A   1 (-3.3A)
STU  A   1 (-3.5A)
None
None
STU  A   1 (-4.1A)
None
STU  A   1 (-4.3A)
0.61A 4c8bA-3ppzA:
28.9
4c8bA-3ppzA:
36.69
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3q4t ACTIVIN RECEPTOR
TYPE-2A


(Homo sapiens)
PF00069
(Pkinase)
7 ALA A 217
LYS A 219
GLU A 232
LEU A 247
THR A 267
LEU A 329
ALA A 339
TAK  A   2 (-3.5A)
TAK  A   2 (-2.9A)
TAK  A   2 ( 4.9A)
None
TAK  A   2 (-3.5A)
TAK  A   2 (-4.6A)
TAK  A   2 ( 4.2A)
0.71A 4c8bA-3q4tA:
24.0
4c8bA-3q4tA:
32.61
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3q4t ACTIVIN RECEPTOR
TYPE-2A


(Homo sapiens)
PF00069
(Pkinase)
7 ALA A 217
LYS A 219
LEU A 247
THR A 267
HIS A 320
LEU A 329
ALA A 339
TAK  A   2 (-3.5A)
TAK  A   2 (-2.9A)
None
TAK  A   2 (-3.5A)
None
TAK  A   2 (-4.6A)
TAK  A   2 ( 4.2A)
0.57A 4c8bA-3q4tA:
24.0
4c8bA-3q4tA:
32.61
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3qfv CDC42BPB PROTEIN

(Homo sapiens)
PF00069
(Pkinase)
7 ALA A 103
LYS A 105
GLU A 124
LEU A 128
HIS A 198
LEU A 207
ALA A 217
NM7  A 416 ( 3.7A)
EDO  A 417 (-3.5A)
EDO  A 417 (-4.0A)
None
None
NM7  A 416 ( 4.2A)
NM7  A 416 ( 4.5A)
0.68A 4c8bA-3qfvA:
16.0
4c8bA-3qfvA:
23.72
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3s95 LIM DOMAIN KINASE 1

(Homo sapiens)
PF07714
(Pkinase_Tyr)
7 LYS A 368
GLU A 384
LEU A 397
THR A 413
HIS A 458
LEU A 467
ALA A 477
STU  A   1 (-3.1A)
STU  A   1 (-3.7A)
STU  A   1 (-4.6A)
STU  A   1 (-3.9A)
None
STU  A   1 (-4.6A)
STU  A   1 ( 4.1A)
0.75A 4c8bA-3s95A:
25.4
4c8bA-3s95A:
23.81
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3v5q NT-3 GROWTH FACTOR
RECEPTOR


(Homo sapiens)
PF07714
(Pkinase_Tyr)
7 ALA A 570
GLU A 588
LEU A 592
HIS A 677
LEU A 686
ASP A 697
PHE A 698
0F4  A 902 (-3.2A)
0F4  A 902 (-3.6A)
0F4  A 902 (-4.7A)
0F4  A 902 (-4.1A)
0F4  A 902 (-4.5A)
None
0F4  A 902 (-4.1A)
1.13A 4c8bA-3v5qA:
26.5
4c8bA-3v5qA:
29.30
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4agu CYCLIN-DEPENDENT
KINASE-LIKE 1


(Homo sapiens)
PF00069
(Pkinase)
7 ALA A  31
LYS A  33
GLU A  51
LEU A  55
HIS A 124
LEU A 133
ASP A 144
D15  A 500 (-3.4A)
D15  A 500 ( 4.1A)
None
None
None
D15  A 500 (-4.5A)
D15  A 500 (-3.7A)
0.82A 4c8bA-4aguA:
24.3
4c8bA-4aguA:
23.29
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4aw2 SERINE/THREONINE-PRO
TEIN KINASE MRCK
ALPHA


(Rattus
norvegicus)
PF00069
(Pkinase)
PF00433
(Pkinase_C)
7 ALA A 104
LYS A 106
GLU A 125
LEU A 129
HIS A 199
LEU A 208
ALA A 218
EDO  A1420 (-3.4A)
EDO  A1419 (-3.3A)
EDO  A1419 (-3.0A)
None
None
EDO  A1420 ( 4.8A)
None
0.56A 4c8bA-4aw2A:
21.0
4c8bA-4aw2A:
24.55
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4bc6 SERINE/THREONINE-PRO
TEIN KINASE 10


(Homo sapiens)
PF00069
(Pkinase)
7 ALA A  63
GLU A  81
LEU A  85
ILE A 108
HIS A 155
LEU A 164
ALA A 174
XZN  A1317 (-3.5A)
XZN  A1317 (-3.9A)
None
XZN  A1317 (-4.4A)
None
XZN  A1317 (-4.7A)
XZN  A1317 ( 4.3A)
0.68A 4c8bA-4bc6A:
23.0
4c8bA-4bc6A:
27.03
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4c02 ACTIVIN RECEPTOR
TYPE-1


(Homo sapiens)
PF00069
(Pkinase)
PF08515
(TGF_beta_GS)
7 ALA A 233
LYS A 235
LEU A 263
THR A 283
HIS A 334
LEU A 343
ALA A 353
TAK  A1507 (-3.3A)
TAK  A1507 ( 4.5A)
FLC  A1503 ( 4.5A)
TAK  A1507 (-3.6A)
None
TAK  A1507 (-4.7A)
TAK  A1507 ( 4.2A)
0.52A 4c8bA-4c02A:
24.2
4c8bA-4c02A:
27.91
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ckr EPITHELIAL DISCOIDIN
DOMAIN-CONTAINING
RECEPTOR 1


(Homo sapiens)
PF07714
(Pkinase_Tyr)
8 ALA A 653
GLU A 672
THR A 701
HIS A 764
LEU A 773
ALA A 783
ASP A 784
PHE A 785
DI1  A1000 (-3.6A)
DI1  A1000 (-3.8A)
DI1  A1000 (-3.6A)
DI1  A1000 (-3.8A)
DI1  A1000 (-4.5A)
DI1  A1000 (-3.7A)
DI1  A1000 (-4.1A)
DI1  A1000 (-4.5A)
0.72A 4c8bA-4ckrA:
25.8
4c8bA-4ckrA:
26.40
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ckr EPITHELIAL DISCOIDIN
DOMAIN-CONTAINING
RECEPTOR 1


(Homo sapiens)
PF07714
(Pkinase_Tyr)
8 ALA A 653
LYS A 655
GLU A 672
THR A 701
HIS A 764
LEU A 773
ALA A 783
ASP A 784
DI1  A1000 (-3.6A)
DI1  A1000 (-3.9A)
DI1  A1000 (-3.8A)
DI1  A1000 (-3.6A)
DI1  A1000 (-3.8A)
DI1  A1000 (-4.5A)
DI1  A1000 (-3.7A)
DI1  A1000 (-4.1A)
0.55A 4c8bA-4ckrA:
25.8
4c8bA-4ckrA:
26.40
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4f99 CELL DIVISION CYCLE
7-RELATED PROTEIN
KINASE


(Homo sapiens)
PF00069
(Pkinase)
7 ALA A  88
LYS A  90
GLU A 104
LEU A 108
ILE A 132
HIS A 175
LEU A 184
ADP  A 601 (-3.5A)
ADP  A 601 (-2.6A)
None
None
None
None
ADP  A 601 ( 4.9A)
0.63A 4c8bA-4f99A:
14.0
4c8bA-4f99A:
27.11
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4hvi TYROSINE-PROTEIN
KINASE JAK3


(Homo sapiens)
PF07714
(Pkinase_Tyr)
8 ALA A 853
LYS A 855
GLU A 871
LEU A 875
HIS A 947
LEU A 956
ALA A 966
ASP A 967
19S  A1201 (-3.3A)
19S  A1201 (-3.5A)
None
None
None
19S  A1201 (-4.5A)
19S  A1201 ( 4.1A)
19S  A1201 ( 4.1A)
0.99A 4c8bA-4hviA:
25.7
4c8bA-4hviA:
29.86
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4l52 MITOGEN-ACTIVATED
PROTEIN KINASE
KINASE KINASE 7,
TGF-BETA-ACTIVATED
KINASE 1 AND
MAP3K7-BINDING
PROTEIN 1 CHIMERA


(Homo sapiens)
PF07714
(Pkinase_Tyr)
7 ALA A  61
LYS A  63
GLU A  77
LEU A  81
HIS A 154
LEU A 163
ASP A 175
1UL  A 501 (-3.1A)
None
None
None
None
1UL  A 501 (-4.3A)
1UL  A 501 (-4.2A)
1.21A 4c8bA-4l52A:
28.9
4c8bA-4l52A:
29.38
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4m69 RECEPTOR-INTERACTING
SERINE/THREONINE-PRO
TEIN KINASE 3


(Mus musculus)
PF00069
(Pkinase)
7 ALA A  49
LYS A  51
LEU A  74
THR A  95
HIS A 141
LEU A 150
ALA A 160
ANP  A 401 (-3.1A)
ANP  A 401 (-2.9A)
None
ANP  A 401 (-3.8A)
None
ANP  A 401 (-4.8A)
None
0.84A 4c8bA-4m69A:
29.2
4c8bA-4m69A:
34.19
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4o27 SERINE/THREONINE-PRO
TEIN KINASE 24


(Homo sapiens)
PF00069
(Pkinase)
9 ALA B  51
LYS B  53
GLU B  70
LEU B  74
ILE B  97
HIS B 142
LEU B 151
ALA B 161
ASP B 162
ADP  B 500 (-3.3A)
ADP  B 500 (-3.1A)
None
None
None
None
ADP  B 500 (-4.7A)
None
ADP  B 500 ( 3.4A)
0.82A 4c8bA-4o27B:
25.1
4c8bA-4o27B:
26.04
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4qny MITOGEN ACTIVATED
PROTEIN KINASE,
PUTATIVE


(Leishmania
donovani)
PF00069
(Pkinase)
8 ALA A  49
LYS A  51
GLU A  70
LEU A  74
ILE A 102
HIS A 147
LEU A 156
ASP A 167
ANP  A 402 (-3.3A)
ANP  A 402 (-2.8A)
ANP  A 402 (-3.0A)
None
None
None
ANP  A 402 (-4.6A)
ANP  A 402 ( 2.6A)
0.96A 4c8bA-4qnyA:
22.0
4c8bA-4qnyA:
24.63
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4qtb MITOGEN-ACTIVATED
PROTEIN KINASE 3


(Homo sapiens)
PF00069
(Pkinase)
7 ALA A  69
LYS A  71
LEU A  92
ILE A 120
HIS A 164
LEU A 173
ASP A 184
38Z  A 418 (-3.4A)
38Z  A 418 (-2.9A)
None
None
None
38Z  A 418 (-4.4A)
38Z  A 418 (-3.5A)
1.11A 4c8bA-4qtbA:
22.0
4c8bA-4qtbA:
25.69
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4rt7 RECEPTOR-TYPE
TYROSINE-PROTEIN
KINASE FLT3


(Homo sapiens)
PF07714
(Pkinase_Tyr)
6 ALA A 642
LYS A 644
GLU A 661
HIS A 809
LEU A 818
ASP A 829
P30  A1001 (-3.4A)
P30  A1001 (-3.4A)
P30  A1001 (-3.6A)
P30  A1001 ( 4.3A)
P30  A1001 (-4.6A)
None
0.41A 4c8bA-4rt7A:
26.8
4c8bA-4rt7A:
26.55
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4tpt LIM DOMAIN KINASE 2

(Homo sapiens)
PF07714
(Pkinase_Tyr)
7 LEU A 389
THR A 405
HIS A 449
LEU A 458
ALA A 468
ASP A 469
PHE A 470
35H  A 701 (-4.6A)
35H  A 701 (-3.8A)
35H  A 701 ( 4.4A)
None
35H  A 701 (-3.5A)
35H  A 701 (-4.7A)
35H  A 701 (-4.4A)
1.02A 4c8bA-4tptA:
21.3
4c8bA-4tptA:
25.14
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ueu TYROSINE KINASE AS -
A COMMON ANCESTOR OF
SRC AND ABL


(synthetic
construct)
PF07714
(Pkinase_Tyr)
9 ALA A  35
LYS A  37
GLU A  52
ILE A  79
THR A  81
HIS A 127
LEU A 136
ALA A 146
ASP A 147
ACP  A1264 (-2.9A)
None
None
None
ACP  A1264 (-4.5A)
None
ACP  A1264 ( 4.8A)
None
None
0.85A 4c8bA-4ueuA:
27.2
4c8bA-4ueuA:
26.28
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4xey TYROSINE-PROTEIN
KINASE ABL1


(Homo sapiens)
no annotation 7 ALA B 288
LYS B 290
ILE B 332
THR B 334
HIS B 380
LEU B 389
ALA B 399
1N1  B 601 (-3.5A)
1N1  B 601 (-4.6A)
1N1  B 601 (-4.1A)
1N1  B 601 (-3.3A)
None
1N1  B 601 (-4.3A)
1N1  B 601 (-3.5A)
0.64A 4c8bA-4xeyB:
26.1
4c8bA-4xeyB:
24.94
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4xrl MITOGEN-ACTIVATED
PROTEIN KINASE 1


(Rattus
norvegicus)
PF00069
(Pkinase)
7 ALA A  50
LYS A  52
LEU A  73
ILE A 101
HIS A 145
LEU A 154
ASP A 165
42A  A 402 (-3.2A)
42A  A 402 (-4.1A)
None
None
None
42A  A 402 ( 4.9A)
None
0.96A 4c8bA-4xrlA:
22.1
4c8bA-4xrlA:
27.32
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4yff SERINE/THREONINE-PRO
TEIN KINASE TNNI3K


(Homo sapiens)
PF07714
(Pkinase_Tyr)
9 ALA A 488
LYS A 490
GLU A 509
LEU A 513
ILE A 537
THR A 539
HIS A 586
LEU A 595
ALA A 605
4CV  A 801 (-3.5A)
4CV  A 801 (-3.9A)
None
None
None
4CV  A 801 (-2.8A)
None
4CV  A 801 (-4.4A)
4CV  A 801 ( 3.9A)
0.91A 4c8bA-4yffA:
25.9
4c8bA-4yffA:
29.53
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ysj CALMODULIN-LIKE
DOMAIN PROTEIN
KINASE


(Eimeria tenella)
PF00069
(Pkinase)
PF13499
(EF-hand_7)
7 ALA A  55
LYS A  57
GLU A  76
LEU A  80
THR A 105
HIS A 149
LEU A 158
ADP  A 506 (-3.3A)
ADP  A 506 (-2.4A)
None
None
ADP  A 506 ( 4.6A)
None
ADP  A 506 (-4.7A)
0.76A 4c8bA-4ysjA:
24.3
4c8bA-4ysjA:
20.40
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4z7g SERINE/THREONINE-PRO
TEIN
KINASE/ENDORIBONUCLE
ASE IRE1


(Homo sapiens)
PF00069
(Pkinase)
PF06479
(Ribonuc_2-5A)
7 ALA A 597
LYS A 599
GLU A 612
LEU A 616
ILE A 640
HIS A 686
LEU A 695
None
0.91A 4c8bA-4z7gA:
21.4
4c8bA-4z7gA:
24.28
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5a46 FIBROBLAST GROWTH
FACTOR RECEPTOR 1
(FMS-RELATED
TYROSINE KINASE 2,
PFEIFFER SYNDROME),
ISOFORM CRA_B


(Homo sapiens)
PF07714
(Pkinase_Tyr)
6 ALA A 512
LYS A 514
GLU A 531
HIS A 621
LEU A 630
ALA A 640
38O  A1769 (-3.6A)
38O  A1769 ( 3.1A)
EDO  A1766 (-4.1A)
None
38O  A1769 (-4.6A)
EDO  A1766 ( 4.4A)
0.41A 4c8bA-5a46A:
19.8
4c8bA-5a46A:
25.31
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ci6 MITOGEN-ACTIVATED
PROTEIN KINASE 6


(Arabidopsis
thaliana)
PF00069
(Pkinase)
7 ALA A  90
LYS A  92
GLU A 110
LEU A 114
ILE A 142
HIS A 187
ASP A 207
None
1.15A 4c8bA-5ci6A:
21.2
4c8bA-5ci6A:
23.41
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ci6 MITOGEN-ACTIVATED
PROTEIN KINASE 6


(Arabidopsis
thaliana)
PF00069
(Pkinase)
7 ALA A  90
LYS A  92
LEU A 114
ILE A 142
HIS A 187
LEU A 196
ASP A 207
None
0.92A 4c8bA-5ci6A:
21.2
4c8bA-5ci6A:
23.41
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5e8y TGF-BETA RECEPTOR
TYPE-2


(Homo sapiens)
PF07714
(Pkinase_Tyr)
7 ALA A 275
GLU A 290
LEU A 305
THR A 325
HIS A 377
LEU A 386
ASP A 397
STU  A 601 (-3.1A)
STU  A 601 ( 3.8A)
STU  A 601 ( 3.8A)
STU  A 601 ( 3.7A)
None
STU  A 601 (-3.9A)
STU  A 601 (-3.0A)
1.00A 4c8bA-5e8yA:
17.9
4c8bA-5e8yA:
27.17
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5e8y TGF-BETA RECEPTOR
TYPE-2


(Homo sapiens)
PF07714
(Pkinase_Tyr)
7 ALA A 275
LYS A 277
GLU A 290
LEU A 305
THR A 325
HIS A 377
LEU A 386
STU  A 601 (-3.1A)
STU  A 601 (-2.4A)
STU  A 601 ( 3.8A)
STU  A 601 ( 3.8A)
STU  A 601 ( 3.7A)
None
STU  A 601 (-3.9A)
0.66A 4c8bA-5e8yA:
17.9
4c8bA-5e8yA:
27.17
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5grn PLATELET-DERIVED
GROWTH FACTOR
RECEPTOR ALPHA


(Homo sapiens)
PF07714
(Pkinase_Tyr)
8 ALA A 625
LYS A 627
GLU A 644
ILE A 672
THR A 674
HIS A 816
LEU A 825
ASP A 836
748  A1001 (-3.7A)
748  A1001 (-4.0A)
748  A1001 (-3.3A)
748  A1001 (-3.9A)
748  A1001 (-3.2A)
748  A1001 (-3.8A)
748  A1001 (-4.3A)
748  A1001 (-4.8A)
0.42A 4c8bA-5grnA:
19.7
4c8bA-5grnA:
27.37
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5idn CYCLIN-DEPENDENT
KINASE 8


(Homo sapiens)
PF00069
(Pkinase)
7 ALA A  50
LYS A  52
LEU A  70
HIS A 149
LEU A 158
ALA A 172
ASP A 173
6A7  A 401 (-3.3A)
6A7  A 401 ( 2.9A)
None
FMT  A 403 (-4.6A)
6A7  A 401 (-4.8A)
6A7  A 401 ( 4.1A)
FMT  A 403 ( 3.3A)
0.87A 4c8bA-5idnA:
22.5
4c8bA-5idnA:
25.92
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5j5t MITOGEN-ACTIVATED
PROTEIN KINASE
KINASE KINASE KINASE
3


(Homo sapiens)
PF00069
(Pkinase)
7 ALA A  43
LYS A  45
GLU A  61
ILE A  88
HIS A 134
LEU A 143
ALA A 153
6G2  A 901 (-3.2A)
6G2  A 901 ( 3.9A)
None
None
None
6G2  A 901 (-4.7A)
6G2  A 901 ( 4.2A)
0.59A 4c8bA-5j5tA:
13.3
4c8bA-5j5tA:
25.41
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ko1 MIXED LINEAGE KINASE
DOMAIN-LIKE PROTEIN


(Homo sapiens)
PF07714
(Pkinase_Tyr)
7 ALA A 228
LYS A 230
LEU A 263
ILE A 281
HIS A 329
LEU A 338
ALA A 348
6UY  A 501 (-3.4A)
6UY  A 501 (-4.0A)
None
None
None
6UY  A 501 (-4.5A)
6UY  A 501 (-3.4A)
0.73A 4c8bA-5ko1A:
27.3
4c8bA-5ko1A:
28.19
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5myv SRSF PROTEIN KINASE
2,SRSF PROTEIN
KINASE 2


(Homo sapiens)
PF00069
(Pkinase)
7 ALA A 119
LYS A 121
GLU A 136
LEU A 140
HIS A 223
LEU A 232
ALA A 540
W4A  A 716 ( 3.9A)
SO4  A 702 (-3.3A)
DMS  A 717 (-4.0A)
None
None
None
DMS  A 717 ( 4.5A)
0.88A 4c8bA-5myvA:
19.9
4c8bA-5myvA:
22.60
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5w5j RECEPTOR-INTERACTING
SERINE/THREONINE-PRO
TEIN KINASE 2


(Homo sapiens)
no annotation 7 ALA A  45
LYS A  47
LEU A  79
ILE A  93
THR A  95
LEU A 153
ALA A 163
9WS  A 401 (-3.3A)
9WS  A 401 (-3.3A)
9WS  A 401 (-4.9A)
9WS  A 401 (-3.9A)
9WS  A 401 (-3.2A)
9WS  A 401 (-4.6A)
9WS  A 401 ( 4.0A)
0.62A 4c8bA-5w5jA:
35.5
4c8bA-5w5jA:
92.99
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5xv7 SERINE-ARGININE (SR)
PROTEIN KINASE 1


(Homo sapiens)
no annotation 7 ALA A 107
LYS A 109
GLU A 124
LEU A 128
HIS A 211
LEU A 220
ALA A 496
EMH  A 705 (-3.6A)
EMH  A 705 ( 4.8A)
None
None
None
None
EMH  A 705 ( 4.0A)
0.86A 4c8bA-5xv7A:
20.5
4c8bA-5xv7A:
12.92
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6b3e CYCLIN-DEPENDENT
KINASE 12


(Homo sapiens)
no annotation 7 ALA A 754
LYS A 756
GLU A 774
LEU A 778
HIS A 857
LEU A 866
ALA A 876
CJM  A1102 (-3.1A)
None
None
None
None
CJM  A1102 (-4.4A)
CJM  A1102 (-3.6A)
0.74A 4c8bA-6b3eA:
24.2
4c8bA-6b3eA:
12.23
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6bql CALCIUM/CALMODULIN-D
EPENDENT PROTEIN
KINASE KINASE 2


(Homo sapiens)
no annotation 7 ALA A 192
LYS A 194
LEU A 240
HIS A 310
LEU A 319
ALA A 329
ASP A 330
BI9  A 501 (-3.3A)
NH4  A 506 ( 4.4A)
None
None
BI9  A 501 (-4.7A)
NH4  A 506 ( 3.7A)
None
0.85A 4c8bA-6bqlA:
22.9
4c8bA-6bqlA:
14.05
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6cmj CALCIUM/CALMODULIN-D
EPENDENT PROTEIN
KINASE KINASE 2


(Homo sapiens)
no annotation 7 ALA A 192
LYS A 194
GLU A 236
LEU A 240
HIS A 310
LEU A 319
ALA A 329
F6J  A 501 (-3.4A)
F6J  A 501 (-2.9A)
F6J  A 501 ( 4.7A)
None
None
F6J  A 501 (-4.5A)
F6J  A 501 ( 4.0A)
0.97A 4c8bA-6cmjA:
23.0
4c8bA-6cmjA:
15.60
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6cnh SERINE/THREONINE-PRO
TEIN KINASE PRP4
HOMOLOG


(Homo sapiens)
no annotation 9 ALA A 715
LYS A 717
GLU A 732
LEU A 736
LEU A 751
HIS A 813
LEU A 822
ASP A 834
PHE A 835
919  A1101 (-3.5A)
SO4  A1102 ( 2.8A)
919  A1101 (-3.7A)
None
919  A1101 (-4.5A)
919  A1101 (-4.2A)
None
919  A1101 (-4.5A)
919  A1101 ( 4.1A)
0.78A 4c8bA-6cnhA:
22.2
4c8bA-6cnhA:
13.67
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6cz4 PROTEIN-TYROSINE
KINASE 6


(Homo sapiens)
no annotation 8 ALA A 217
LEU A 248
ILE A 262
THR A 264
HIS A 310
LEU A 319
ASP A 330
PHE A 331
FKY  A9001 (-3.3A)
FKY  A9001 (-4.2A)
None
FKY  A9001 (-3.0A)
FKY  A9001 (-3.9A)
FKY  A9001 ( 4.9A)
None
FKY  A9001 (-3.9A)
0.92A 4c8bA-6cz4A:
25.4
4c8bA-6cz4A:
14.86
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6fyl DUAL SPECIFICITY
PROTEIN KINASE CLK2


(Homo sapiens)
no annotation 7 ALA A 191
LYS A 193
GLU A 208
ILE A 241
HIS A 288
LEU A 297
ASP A 327
3NG  A 501 (-3.3A)
3NG  A 501 (-3.0A)
3NG  A 501 ( 4.9A)
None
None
None
3NG  A 501 (-4.5A)
0.95A 4c8bA-6fylA:
22.1
4c8bA-6fylA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6fyl DUAL SPECIFICITY
PROTEIN KINASE CLK2


(Homo sapiens)
no annotation 7 ALA A 191
LYS A 193
GLU A 208
LEU A 212
ILE A 241
HIS A 288
ASP A 327
3NG  A 501 (-3.3A)
3NG  A 501 (-3.0A)
3NG  A 501 ( 4.9A)
None
None
None
3NG  A 501 (-4.5A)
1.02A 4c8bA-6fylA:
22.1
4c8bA-6fylA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6fyv DUAL SPECIFICITY
PROTEIN KINASE CLK4


(Homo sapiens)
no annotation 7 ALA A 189
GLU A 206
LEU A 210
ILE A 239
HIS A 286
LEU A 295
ASP A 325
3NG  A 501 (-3.5A)
3NG  A 501 ( 4.7A)
None
None
None
None
3NG  A 501 (-4.3A)
1.06A 4c8bA-6fyvA:
22.4
4c8bA-6fyvA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6fyv DUAL SPECIFICITY
PROTEIN KINASE CLK4


(Homo sapiens)
no annotation 7 ALA A 189
LYS A 191
GLU A 206
LEU A 210
ILE A 239
HIS A 286
LEU A 295
3NG  A 501 (-3.5A)
3NG  A 501 (-2.7A)
3NG  A 501 ( 4.7A)
None
None
None
None
0.75A 4c8bA-6fyvA:
22.4
4c8bA-6fyvA:
undetectable