SIMILAR PATTERNS OF AMINO ACIDS FOR 4C66_A_H4CA1168

List of similar pattern of amino acids derived from ASSAM search

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click link on the last column to view superposed patterns of amino acids in NGL viewer)
(Note that only 3-12 residue patterns can be used for ASSAM searches)
Filter list by:
Hit Macromolecule/
Organism		 Pfam Res. Interface HETATM RMSD Dali Z-score Seq. Identity (%) View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1d2o COLLAGEN ADHESIN

(Staphylococcus
aureus) 		PF05738
(Cna_B) 		5 PRO A 589
VAL A 570
LEU A 563
ASN A 566
ILE A 597
 None
 1.42A 4c66A-1d2oA:
undetectable		 4c66A-1d2oA:
21.65
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1d2p COLLAGEN ADHESIN

(Staphylococcus
aureus) 		PF05738
(Cna_B) 		5 PRO A 589
VAL A 570
LEU A 563
ASN A 566
ILE A 597
 None
 1.43A 4c66A-1d2pA:
undetectable		 4c66A-1d2pA:
15.70
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ds9 OUTER ARM DYNEIN

(Chlamydomonas
reinhardtii) 		PF12799
(LRR_4) 		5 VAL A 115
LEU A 145
LEU A 147
ASN A 103
ILE A 100
 None
 1.41A 4c66A-1ds9A:
undetectable		 4c66A-1ds9A:
19.68
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1im4 DBH

(Sulfolobus
solfataricus) 		PF00817
(IMS)
PF11798
(IMS_HHH) 		5 PRO A 185
LEU A 179
LEU A 176
ASN A 148
ILE A 150
 None
 1.30A 4c66A-1im4A:
undetectable		 4c66A-1im4A:
20.27
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2bws XAA-PRO
AMINOPEPTIDASE P

(Escherichia
coli) 		PF00557
(Peptidase_M24)
PF05195
(AMP_N) 		5 PRO A 277
GLN A 286
LEU A 294
ILE A 430
MET A 434
 None
 1.26A 4c66A-2bwsA:
undetectable		 4c66A-2bwsA:
14.77
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2dvr BROMODOMAIN-CONTAINI
NG PROTEIN 2

(Homo sapiens) 		PF00439
(Bromodomain) 		9 TRP A  31
PRO A  32
GLN A  35
VAL A  37
LEU A  42
LEU A  44
ASN A  90
ILE A  96
MET A  99
 None
 0.42A 4c66A-2dvrA:
20.3		 4c66A-2dvrA:
64.96
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2e6m WERNER SYNDROME
ATP-DEPENDENT
HELICASE HOMOLOG

(Mus musculus) 		PF01612
(DNA_pol_A_exo1) 		5 PRO A 115
VAL A 147
LEU A 122
ILE A 108
MET A 111
 None
 1.10A 4c66A-2e6mA:
undetectable		 4c66A-2e6mA:
22.12
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2l5e BROMODOMAIN-CONTAINI
NG PROTEIN 3

(Mus musculus) 		PF00439
(Bromodomain) 		6 TRP A  57
PRO A  58
GLN A  61
ASN A 116
ILE A 122
MET A 125
 None
 0.78A 4c66A-2l5eA:
17.5		 4c66A-2l5eA:
76.98
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2l5e BROMODOMAIN-CONTAINI
NG PROTEIN 3

(Mus musculus) 		PF00439
(Bromodomain) 		7 TRP A  57
PRO A  58
LEU A  68
LEU A  70
ASN A 116
ILE A 122
MET A 125
 None
 1.10A 4c66A-2l5eA:
17.5		 4c66A-2l5eA:
76.98
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2lav VACCINIA-RELATED
KINASE 1

(Homo sapiens) 		PF00069
(Pkinase) 		5 PRO A 296
LEU A 155
LEU A 324
ILE A 299
MET A 286
 None
 1.48A 4c66A-2lavA:
undetectable		 4c66A-2lavA:
16.00
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2wp1 BROMODOMAIN
TESTIS-SPECIFIC
PROTEIN

(Mus musculus) 		PF00439
(Bromodomain) 		7 TRP A 292
PRO A 293
VAL A 298
LEU A 303
LEU A 305
ASN A 351
MET A 360
 None
 0.66A 4c66A-2wp1A:
16.8		 4c66A-2wp1A:
38.46
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2xwg SORTASE

(Actinomyces
oris) 		PF04203
(Sortase) 		5 PRO A 191
VAL A 261
LEU A 263
ILE A 169
MET A 155
 None
 1.46A 4c66A-2xwgA:
undetectable		 4c66A-2xwgA:
17.47
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2yek BROMODOMAIN-CONTAINI
NG PROTEIN 2

(Homo sapiens) 		PF00439
(Bromodomain) 		8 TRP A  97
PRO A  98
VAL A 103
LEU A 108
LEU A 110
ASN A 156
ILE A 162
MET A 165
 None
EAM  A1188 (-4.6A)
EAM  A1188 (-4.4A)
EAM  A1188 ( 3.8A)
EAM  A1188 (-4.5A)
EAM  A1188 (-3.2A)
EAM  A1188 (-3.8A)
EAM  A1188 ( 4.1A)
 0.47A 4c66A-2yekA:
20.4		 4c66A-2yekA:
69.85
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2yek BROMODOMAIN-CONTAINI
NG PROTEIN 2

(Homo sapiens) 		PF00439
(Bromodomain) 		5 VAL A 103
LEU A 108
ASN A 156
ILE A 162
MET A 165
 EAM  A1188 (-4.4A)
EAM  A1188 ( 3.8A)
EAM  A1188 (-3.2A)
EAM  A1188 (-3.8A)
EAM  A1188 ( 4.1A)
 1.43A 4c66A-2yekA:
20.4		 4c66A-2yekA:
69.85
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3h1l MITOCHONDRIAL
UBIQUINOL-CYTOCHROME
-C REDUCTASE COMPLEX
CORE PROTEIN I

(Gallus gallus) 		PF00675
(Peptidase_M16)
PF05193
(Peptidase_M16_C) 		5 GLN A 368
VAL A 366
LEU A 392
LEU A   8
ILE A 399
 None
 1.21A 4c66A-3h1lA:
undetectable		 4c66A-3h1lA:
13.48
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ig4 XAA-PRO
AMINOPEPTIDASE

(Bacillus
anthracis) 		PF00557
(Peptidase_M24)
PF05195
(AMP_N) 		5 PRO A 273
GLN A 282
LEU A 290
ILE A 408
MET A 412
 None
 1.18A 4c66A-3ig4A:
undetectable		 4c66A-3ig4A:
15.29
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3jb9 PRE-MRNA-SPLICING
FACTOR CWF10

(Schizosaccharomyces
pombe) 		PF00009
(GTP_EFTU)
PF00679
(EFG_C)
PF03144
(GTP_EFTU_D2)
PF03764
(EFG_IV)
PF16004
(EFTUD2) 		5 PRO B 890
GLN B 919
VAL B 921
LEU B 943
ILE B 892
 None
 1.23A 4c66A-3jb9B:
undetectable		 4c66A-3jb9B:
7.36
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3nxb CAT EYE SYNDROME
CRITICAL REGION
PROTEIN 2

(Homo sapiens) 		PF00439
(Bromodomain) 		5 TRP A 457
PRO A 458
VAL A 463
ASN A 514
MET A 523
 None
None
EDO  A   1 (-4.3A)
EDO  A   1 (-3.3A)
None
 0.57A 4c66A-3nxbA:
16.3		 4c66A-3nxbA:
32.56
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3oig ENOYL-[ACYL-CARRIER-
PROTEIN] REDUCTASE
[NADH]

(Bacillus
subtilis) 		PF13561
(adh_short_C2) 		5 VAL A 186
LEU A 175
LEU A 179
ILE A  91
MET A  13
 None
 1.47A 4c66A-3oigA:
undetectable		 4c66A-3oigA:
18.78
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3rmt 3-PHOSPHOSHIKIMATE
1-CARBOXYVINYLTRANSF
ERASE 1

(Bacillus
halodurans) 		PF00275
(EPSP_synthase) 		5 PRO A 321
VAL A 325
LEU A 357
LEU A 360
ILE A 393
 None
 1.24A 4c66A-3rmtA:
undetectable		 4c66A-3rmtA:
14.07
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3s6h N-ACETYLGLUTAMATE
KINASE /
N-ACETYLGLUTAMATE
SYNTHASE

(Maricaulis
maris) 		PF00696
(AA_kinase)
PF04768
(NAT) 		5 PRO A 155
VAL A 144
LEU A  98
ASN A 188
ILE A 189
 None
 1.40A 4c66A-3s6hA:
undetectable		 4c66A-3s6hA:
12.69
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4exq UROPORPHYRINOGEN
DECARBOXYLASE

(Burkholderia
thailandensis) 		PF01208
(URO-D) 		5 GLN A 143
VAL A 145
LEU A  65
LEU A  70
ILE A 148
 None
 1.45A 4c66A-4exqA:
undetectable		 4c66A-4exqA:
16.81
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4f4w DNA POLYMERASE IV

(Sulfolobus
acidocaldarius;
Sulfolobus
solfataricus) 		PF00817
(IMS)
PF11798
(IMS_HHH) 		5 PRO A 185
LEU A 179
LEU A 176
ASN A 148
ILE A 150
 None
 1.44A 4c66A-4f4wA:
undetectable		 4c66A-4f4wA:
17.37
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4hbx BROMODOMAIN-CONTAINI
NG PROTEIN 4

(Homo sapiens) 		PF00439
(Bromodomain) 		9 TRP A  81
PRO A  82
GLN A  85
VAL A  87
LEU A  92
LEU A  94
ASN A 140
ILE A 146
MET A 149
 None
14X  A 201 (-4.4A)
None
14X  A 201 (-4.7A)
14X  A 201 (-4.4A)
None
14X  A 201 (-3.1A)
14X  A 201 ( 4.0A)
14X  A 201 (-3.5A)
 0.57A 4c66A-4hbxA:
24.7		 4c66A-4hbxA:
100.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4n3w CREB-BINDING PROTEIN

(Homo sapiens) 		PF00439
(Bromodomain)
PF06001
(DUF902) 		5 PRO A1110
GLN A1113
VAL A1115
LEU A1120
ASN A1168
 None
 0.66A 4c66A-4n3wA:
13.7		 4c66A-4n3wA:
20.42
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4pv4 PROLINE
AMINOPEPTIDASE P II

(Yersinia pestis) 		PF00557
(Peptidase_M24)
PF05195
(AMP_N) 		5 PRO A 275
GLN A 284
LEU A 292
ILE A 429
MET A 433
 None
 1.30A 4c66A-4pv4A:
undetectable		 4c66A-4pv4A:
14.57
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4qqv INTERLEUKIN-3
RECEPTOR CLASS 2
SUBUNIT BETA

(Mus musculus) 		PF09240
(IL6Ra-bind)
PF09294
(Interfer-bind) 		5 PRO A 116
GLN A 114
VAL A 113
LEU A 198
LEU A 204
 None
 1.26A 4c66A-4qqvA:
undetectable		 4c66A-4qqvA:
13.88
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4uvk ZYRO0D15994P

(Zygosaccharomyces
rouxii) 		PF08514
(STAG) 		5 GLN A 720
VAL A 721
LEU A 729
LEU A 732
ILE A 689
 None
 1.48A 4c66A-4uvkA:
undetectable		 4c66A-4uvkA:
7.99
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4uyd BROMODOMAIN-CONTAINI
NG PROTEIN 4

(Homo sapiens) 		PF00439
(Bromodomain) 		9 TRP A  81
PRO A  82
GLN A  85
VAL A  87
LEU A  92
LEU A  94
ASN A 140
ILE A 146
MET A 149
 None
V1T  A1171 (-4.2A)
V1T  A1171 (-4.6A)
V1T  A1171 (-4.9A)
V1T  A1171 (-3.8A)
None
V1T  A1171 (-3.1A)
DMS  A1169 ( 4.3A)
DMS  A1169 ( 3.8A)
 0.35A 4c66A-4uydA:
25.1		 4c66A-4uydA:
92.65
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4uyg BROMODOMAIN-CONTAINI
NG PROTEIN 2

(Homo sapiens) 		PF00439
(Bromodomain) 		7 TRP A 370
PRO A 371
VAL A 376
LEU A 381
LEU A 383
ASN A 429
MET A 438
 None
None
73B  A1456 (-4.0A)
73B  A1456 (-4.9A)
73B  A1456 (-4.9A)
73B  A1456 (-3.3A)
73B  A1456 ( 3.8A)
 0.43A 4c66A-4uygA:
18.0		 4c66A-4uygA:
35.06
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4z93 BROMODOMAIN-CONTAINI
NG PROTEIN 4

(Homo sapiens) 		PF00439
(Bromodomain) 		7 TRP A 374
PRO A 375
VAL A 380
LEU A 385
LEU A 387
ASN A 433
MET A 442
 4LD  A 501 (-3.9A)
4LD  A 501 (-3.9A)
4LD  A 501 ( 3.8A)
4LD  A 501 (-4.1A)
4LD  A 501 (-4.4A)
4LD  A 501 (-2.8A)
4LD  A 501 ( 3.4A)
 0.50A 4c66A-4z93A:
17.7		 4c66A-4z93A:
36.51
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5enf PH-INTERACTING
PROTEIN

(Homo sapiens) 		PF00439
(Bromodomain) 		5 PRO A1340
GLN A1343
VAL A1345
ILE A1403
MET A1406
 None
None
5Q7  A1503 (-4.0A)
5Q7  A1503 ( 3.9A)
None
 0.95A 4c66A-5enfA:
14.9		 4c66A-5enfA:
27.27
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5hjc BROMODOMAIN-CONTAINI
NG PROTEIN 3

(Homo sapiens) 		PF00439
(Bromodomain) 		7 TRP A 332
PRO A 333
VAL A 338
LEU A 343
LEU A 345
ASN A 391
MET A 400
 None
 0.56A 4c66A-5hjcA:
18.0		 4c66A-5hjcA:
39.29
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5i8g CREB-BINDING PROTEIN

(Homo sapiens) 		PF00439
(Bromodomain)
PF06001
(DUF902) 		5 PRO A1110
GLN A1113
VAL A1115
LEU A1120
ASN A1168
 69E  A1404 (-3.7A)
69E  A1404 (-3.4A)
69E  A1404 (-4.3A)
69E  A1404 (-4.2A)
69E  A1404 (-3.0A)
 0.75A 4c66A-5i8gA:
16.2		 4c66A-5i8gA:
22.32
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ip7 DNA-DIRECTED RNA
POLYMERASES I, II,
AND III SUBUNIT
RPABC1

(Saccharomyces
cerevisiae) 		PF01191
(RNA_pol_Rpb5_C)
PF03871
(RNA_pol_Rpb5_N) 		5 PRO E 151
VAL E 184
LEU E 188
LEU E 190
ILE E 198
 None
 1.34A 4c66A-5ip7E:
undetectable		 4c66A-5ip7E:
17.44
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5kku POLYKETIDE SYNTHASE
TYPE I

(Bacillus
amyloliquefaciens) 		PF14765
(PS-DH) 		5 PRO A  34
VAL A  66
ASN A  19
ILE A  21
MET A 159
 None
 1.24A 4c66A-5kkuA:
undetectable		 4c66A-5kkuA:
20.16
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5lpk HISTONE
ACETYLTRANSFERASE
P300

(Homo sapiens) 		PF00439
(Bromodomain) 		5 PRO A1074
GLN A1077
VAL A1079
LEU A1084
ASN A1132
 XDM  A1201 (-3.9A)
None
XDM  A1201 (-4.7A)
XDM  A1201 ( 4.4A)
XDM  A1201 (-3.1A)
 0.49A 4c66A-5lpkA:
17.1		 4c66A-5lpkA:
31.58
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5n15 BROMODOMAIN-CONTAINI
NG FACTOR 1

(Candida
albicans) 		PF00439
(Bromodomain) 		6 PRO A 233
VAL A 238
LEU A 243
ASN A 291
ILE A 297
MET A 300
 IOD  A 405 ( 4.4A)
None
None
IOD  A 404 (-3.9A)
IOD  A 404 ( 4.8A)
None
 0.55A 4c66A-5n15A:
18.4		 4c66A-5n15A:
36.23
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5nii THIOREDOXIN
REDUCTASE

(Desulfovibrio
vulgaris) 		no annotation 5 PRO A 115
LEU A 201
LEU A 207
ILE A 225
MET A 227
 None
 1.49A 4c66A-5niiA:
undetectable		 4c66A-5niiA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5u6v BROMODOMAIN-CONTAINI
NG PROTEIN 2

(Homo sapiens) 		no annotation 7 TRP A 370
PRO A 371
VAL A 376
LEU A 381
LEU A 383
ASN A 429
MET A 438
 None
7WY  A 501 (-4.4A)
7WY  A 501 ( 4.5A)
7WY  A 501 (-4.9A)
None
7WY  A 501 (-3.4A)
7WY  A 501 ( 3.9A)
 0.40A 4c66A-5u6vA:
18.0		 4c66A-5u6vA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5u7g CREB-BINDING PROTEIN

(Mus musculus) 		PF00439
(Bromodomain)
PF00569
(ZZ)
PF06001
(DUF902)
PF08214
(HAT_KAT11) 		5 PRO A1111
GLN A1114
VAL A1116
LEU A1121
ASN A1169
 None
 0.77A 4c66A-5u7gA:
16.7		 4c66A-5u7gA:
12.30
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ujs UDP-N-ACETYLGLUCOSAM
INE
1-CARBOXYVINYLTRANSF
ERASE

(Campylobacter
jejuni) 		PF00275
(EPSP_synthase) 		5 PRO A 113
VAL A 144
LEU A 127
ASN A 167
ILE A  95
 None
 1.40A 4c66A-5ujsA:
undetectable		 4c66A-5ujsA:
14.63
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5v84 CAT EYE SYNDROME
CRITICAL REGION
PROTEIN 2

(Homo sapiens) 		PF00439
(Bromodomain) 		5 TRP A 457
PRO A 458
VAL A 463
ASN A 514
MET A 523
 None
96V  A 602 (-4.5A)
96V  A 602 (-3.9A)
96V  A 602 (-2.6A)
None
 0.29A 4c66A-5v84A:
16.3		 4c66A-5v84A:
28.87
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5vbr BROMODOMAIN
TESTIS-SPECIFIC
PROTEIN

(Homo sapiens) 		no annotation 8 TRP A  50
PRO A  51
VAL A  56
LEU A  61
LEU A  63
ASN A 109
ILE A 115
MET A 118
 CL  A 208 (-4.9A)
IBI  A 201 (-4.3A)
IBI  A 201 ( 4.6A)
IBI  A 201 (-4.2A)
IBI  A 201 (-4.9A)
IBI  A 201 (-3.3A)
IBI  A 201 ( 3.8A)
None
 0.50A 4c66A-5vbrA:
19.2		 4c66A-5vbrA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5wab PUTATIVE
BETA-GLUCOSIDASE

(Bifidobacterium
adolescentis) 		no annotation 5 GLN A 273
LEU A 215
LEU A 219
ILE A 228
MET A 281
 None
 1.44A 4c66A-5wabA:
undetectable		 4c66A-5wabA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ybb TYPE I
RESTRICTION-MODIFICA
TION SYSTEM
METHYLTRANSFERASE
SUBUNIT

(Caldanaerobacter
subterraneus) 		no annotation 5 PRO A 295
GLN A 297
LEU A 304
LEU A 262
ILE A 266
 None
None
None
SAM  A 601 ( 4.2A)
None
 1.40A 4c66A-5ybbA:
undetectable		 4c66A-5ybbA:
11.59
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6ap4 DNA POLYMERASE III
SUBUNIT BETA

(Acinetobacter
baumannii) 		no annotation 5 PRO A 368
GLN A 366
VAL A 365
LEU A 347
LEU A 344
 None
 1.41A 4c66A-6ap4A:
undetectable		 4c66A-6ap4A:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6dne BROMODOMAIN-CONTAINI
NG PROTEIN 4

(Homo sapiens) 		no annotation 9 TRP A  81
PRO A  82
GLN A  85
VAL A  87
LEU A  92
LEU A  94
ASN A 140
ILE A 146
MET A 149
 None
H1V  A 501 (-4.6A)
H1V  A 501 ( 4.5A)
H1V  A 501 ( 4.4A)
H1V  A 501 (-4.2A)
H1V  A 501 (-4.7A)
H1V  A 501 (-3.2A)
H1V  A 501 (-3.8A)
H1V  A 501 ( 3.8A)
 0.52A 4c66A-6dneA:
23.4		 4c66A-6dneA:
undetectable