SIMILAR PATTERNS OF AMINO ACIDS FOR 4C5N_C_PXLC300_1

List of similar pattern of amino acids derived from ASSAM search

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click link on the last column to view superposed patterns of amino acids in NGL viewer)
(Note that only 3-12 residue patterns can be used for ASSAM searches)
Filter list by:
Hit Macromolecule/
Organism		 Pfam Res. Interface HETATM RMSD Dali Z-score Seq. Identity (%) View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ac5 KEX1(DELTA)P

(Saccharomyces
cerevisiae) 		PF00450
(Peptidase_S10) 		4 ASP A 463
GLY A 460
VAL A 469
VAL A 441
 None
 0.85A 4c5nC-1ac5A:
3.0		 4c5nC-1ac5A:
19.63
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1c41 LUMAZINE SYNTHASE

(Magnaporthe
grisea) 		PF00885
(DMRL_synthase) 		4 GLY A 181
ASP A 179
GLY A 177
HIS A 174
 None
 0.78A 4c5nC-1c41A:
3.7		 4c5nC-1c41A:
21.20
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1cbg CYANOGENIC
BETA-GLUCOSIDASE

(Trifolium
repens) 		PF00232
(Glyco_hydro_1) 		4 GLY A  36
ASP A  66
GLY A  65
HIS A  53
 None
 0.77A 4c5nC-1cbgA:
2.5		 4c5nC-1cbgA:
19.80
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1dwa MYROSINASE MA1

(Sinapis alba) 		PF00232
(Glyco_hydro_1) 		4 GLY M  42
ASP M  70
GLY M  69
HIS M  56
 None
ZN  M 923 (-2.2A)
None
ZN  M 923 (-3.2A)
 0.77A 4c5nC-1dwaM:
3.1		 4c5nC-1dwaM:
20.39
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1fc9 PHOTOSYSTEM II D1
PROTEASE

(Tetradesmus
obliquus) 		PF03572
(Peptidase_S41)
PF13180
(PDZ_2) 		4 GLY A 307
GLY A 278
VAL A 363
VAL A 263
 None
 0.69A 4c5nC-1fc9A:
undetectable		 4c5nC-1fc9A:
20.75
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1fj7 NUCLEOLIN RBD1

(Mesocricetus
auratus) 		PF00076
(RRM_1) 		4 GLY A  61
GLY A  23
VAL A  63
VAL A  82
 None
 0.89A 4c5nC-1fj7A:
undetectable		 4c5nC-1fj7A:
19.16
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1gaj HIGH-AFFINITY
BRANCHED CHAIN AMINO
ACID TRANSPORT
ATP-BINDING PROTEIN

(Methanocaldococcus
jannaschii) 		PF00005
(ABC_tran) 		4 ASP A  34
GLY A  33
VAL A  30
MET A 174
 None
 0.87A 4c5nC-1gajA:
2.2		 4c5nC-1gajA:
21.40
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ivh ISOVALERYL-COA
DEHYDROGENASE

(Homo sapiens) 		PF00441
(Acyl-CoA_dh_1)
PF02770
(Acyl-CoA_dh_M)
PF02771
(Acyl-CoA_dh_N) 		4 GLY A  71
GLY A  62
VAL A 109
HIS A 100
 None
 0.77A 4c5nC-1ivhA:
undetectable		 4c5nC-1ivhA:
23.51
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1jxi PHOSPHOMETHYLPYRIMID
INE KINASE

(Salmonella
enterica) 		PF08543
(Phos_pyr_kin) 		8 GLY A  11
ASP A  13
GLY A  19
VAL A  42
MET A  80
VAL A 107
HIS A 209
CYH A 213
 HMH  A2001 (-3.6A)
None
HMH  A2001 ( 3.8A)
None
HMH  A2001 ( 4.5A)
HMH  A2001 ( 4.7A)
SO4  A2005 (-4.3A)
HMH  A2001 (-3.6A)
 0.53A 4c5nC-1jxiA:
31.3		 4c5nC-1jxiA:
28.81
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1k7h ALKALINE PHOSPHATASE

(Pandalus
borealis) 		PF00245
(Alk_phosphatase) 		4 GLY A 311
ASP A  37
GLY A  36
HIS A 357
 None
ZN  A 478 ( 2.1A)
None
ZN  A 478 (-3.1A)
 0.85A 4c5nC-1k7hA:
undetectable		 4c5nC-1k7hA:
21.37
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1rlh CONSERVED
HYPOTHETICAL PROTEIN

(Thermoplasma
acidophilum) 		PF04008
(Adenosine_kin) 		4 GLY A  37
ASP A  52
GLY A  53
VAL A  31
 None
 0.69A 4c5nC-1rlhA:
undetectable		 4c5nC-1rlhA:
18.69
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1ub0 PHOSPHOMETHYLPYRIMID
INE KINASE

(Thermus
thermophilus) 		PF08543
(Phos_pyr_kin) 		6 GLY A   9
ASP A  11
GLY A  17
VAL A 105
HIS A 206
CYH A 210
 None
 0.44A 4c5nC-1ub0A:
34.0		 4c5nC-1ub0A:
36.12
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1v02 DHURRINASE

(Sorghum bicolor) 		PF00232
(Glyco_hydro_1) 		4 GLY A  42
ASP A  72
GLY A  71
HIS A  59
 None
 0.81A 4c5nC-1v02A:
2.3		 4c5nC-1v02A:
18.72
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1v6u ENDO-1,4-BETA-D-XYLA
NASE

(Streptomyces
olivaceoviridis) 		PF00331
(Glyco_hydro_10)
PF00652
(Ricin_B_lectin) 		4 ASP A  65
GLY A  64
VAL A  78
HIS A 115
 None
 0.80A 4c5nC-1v6uA:
3.2		 4c5nC-1v6uA:
20.09
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1v6y ENDO-1,4-BETA-D-XYLA
NASE AND
ENDO-1,4-BETA-XYLANA
SE B

(Cellulomonas
fimi;
Streptomyces
olivaceoviridis) 		PF00331
(Glyco_hydro_10) 		4 ASP A  65
GLY A  64
VAL A  78
HIS A 115
 None
 0.80A 4c5nC-1v6yA:
3.0		 4c5nC-1v6yA:
21.78
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1v8b ADENOSYLHOMOCYSTEINA
SE

(Plasmodium
falciparum) 		PF00670
(AdoHcyase_NAD)
PF05221
(AdoHcyase) 		4 GLY A 269
ASP A 267
GLY A 266
VAL A 236
 None
NAD  A 501 (-4.4A)
NAD  A 501 (-3.5A)
None
 0.77A 4c5nC-1v8bA:
5.9		 4c5nC-1v8bA:
17.31
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1wcg THIOGLUCOSIDASE

(Brevicoryne
brassicae) 		PF00232
(Glyco_hydro_1) 		4 GLY A  22
ASP A  52
GLY A  51
HIS A  39
 None
 0.86A 4c5nC-1wcgA:
undetectable		 4c5nC-1wcgA:
20.43
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1wnb PUTATIVE BETAINE
ALDEHYDE
DEHYDROGENASE

(Escherichia
coli) 		PF00171
(Aldedh) 		4 ASP A 209
GLY A 208
VAL A 220
HIS A 231
 NAI  A1001 (-3.2A)
NAI  A1001 (-3.4A)
None
NAI  A1001 (-3.9A)
 0.83A 4c5nC-1wnbA:
2.8		 4c5nC-1wnbA:
19.12
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2bnh RIBONUCLEASE
INHIBITOR

(Sus scrofa) 		PF13516
(LRR_6) 		4 GLY A 295
ASP A 293
GLY A 292
VAL A 315
 None
 0.86A 4c5nC-2bnhA:
2.0		 4c5nC-2bnhA:
20.79
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2gez L-ASPARAGINASE ALPHA
SUBUNIT
L-ASPARAGINASE BETA
SUBUNIT

(Lupinus luteus) 		PF01112
(Asparaginase_2) 		4 GLY B 246
GLY B 244
VAL B 254
HIS A   9
 CL  B 406 ( 3.8A)
None
None
None
 0.76A 4c5nC-2gezB:
undetectable		 4c5nC-2gezB:
23.47
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2glf PROBABLE M18-FAMILY
AMINOPEPTIDASE 1

(Thermotoga
maritima) 		PF02127
(Peptidase_M18) 		4 GLY A 420
ASP A 328
GLY A 327
HIS A  94
 None
MN  A5001 (-2.2A)
None
MN  A5001 (-3.6A)
 0.76A 4c5nC-2glfA:
undetectable		 4c5nC-2glfA:
23.27
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2i5b PHOSPHOMETHYLPYRIMID
INE KINASE

(Bacillus
subtilis) 		PF08543
(Phos_pyr_kin) 		8 GLY A  11
ASP A  13
GLY A  19
VAL A  42
MET A  82
VAL A 109
HIS A 212
CYH A 216
 None
 0.32A 4c5nC-2i5bA:
41.8		 4c5nC-2i5bA:
49.63
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2j7c BETA-GLUCOSIDASE A

(Thermotoga
maritima) 		PF00232
(Glyco_hydro_1) 		4 GLY A  23
ASP A  52
GLY A  51
HIS A  40
 None
 0.76A 4c5nC-2j7cA:
2.0		 4c5nC-2j7cA:
21.32
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2jfe CYTOSOLIC
BETA-GLUCOSIDASE

(Homo sapiens) 		PF00232
(Glyco_hydro_1) 		4 GLY X  20
ASP X  50
GLY X  49
HIS X  37
 None
 0.84A 4c5nC-2jfeX:
3.5		 4c5nC-2jfeX:
19.41
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2p3w PROBABLE SERINE
PROTEASE HTRA3

(Homo sapiens) 		PF13180
(PDZ_2) 		4 ASP A 404
GLY A 405
VAL A 391
VAL A 436
 None
 0.82A 4c5nC-2p3wA:
undetectable		 4c5nC-2p3wA:
15.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2r2d ZN-DEPENDENT
HYDROLASES

(Agrobacterium
fabrum) 		PF00753
(Lactamase_B) 		4 GLY A 118
ASP A 115
GLY A  60
HIS A 259
 None
PO4  A 279 (-2.9A)
None
ZN  A 277 (-3.2A)
 0.84A 4c5nC-2r2dA:
undetectable		 4c5nC-2r2dA:
22.26
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2uvf EXOPOLYGALACTURONASE

(Yersinia
enterocolitica) 		PF00295
(Glyco_hydro_28)
PF12708
(Pectate_lyase_3) 		4 GLY A 464
ASP A 462
GLY A 436
CYH A 404
 None
 0.59A 4c5nC-2uvfA:
undetectable		 4c5nC-2uvfA:
18.91
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2wu5 SUCCINATE
DEHYDROGENASE
FLAVOPROTEIN SUBUNIT

(Escherichia
coli) 		PF00890
(FAD_binding_2)
PF02910
(Succ_DH_flav_C) 		4 GLY A 204
GLY A 206
MET A 356
CYH A 353
 None
 0.72A 4c5nC-2wu5A:
undetectable		 4c5nC-2wu5A:
17.60
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2x05 EXO-BETA-D-GLUCOSAMI
NIDASE

(Amycolatopsis
orientalis) 		PF00703
(Glyco_hydro_2)
PF02837
(Glyco_hydro_2_N) 		4 GLY A 514
GLY A 533
VAL A 519
HIS A 625
 None
 0.67A 4c5nC-2x05A:
undetectable		 4c5nC-2x05A:
15.66
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ahx BETA-GLUCOSIDASE A

(Clostridium
cellulovorans) 		PF00232
(Glyco_hydro_1) 		4 GLY A  23
ASP A  52
GLY A  51
HIS A  40
 None
 0.70A 4c5nC-3ahxA:
undetectable		 4c5nC-3ahxA:
20.70
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3aiv BETA-GLUCOSIDASE

(Secale cereale) 		PF00232
(Glyco_hydro_1) 		4 GLY A  46
ASP A  76
GLY A  75
HIS A  63
 None
 0.87A 4c5nC-3aivA:
2.8		 4c5nC-3aivA:
18.02
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3dmy PROTEIN FDRA

(Escherichia
coli) 		PF00549
(Ligase_CoA)
PF02629
(CoA_binding) 		4 GLY A 172
ASP A 174
GLY A 227
VAL A 235
 None
 0.83A 4c5nC-3dmyA:
undetectable		 4c5nC-3dmyA:
21.84
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3e2d ALKALINE PHOSPHATASE

(Vibrio sp.
G15-21) 		PF00245
(Alk_phosphatase) 		4 GLY A 269
ASP A  12
GLY A  11
HIS A 316
 None
ZN  A 602 (-2.2A)
None
ZN  A 602 ( 3.2A)
 0.89A 4c5nC-3e2dA:
undetectable		 4c5nC-3e2dA:
22.26
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3e5m NMRA-LIKE FAMILY
DOMAIN-CONTAINING
PROTEIN 1

(Homo sapiens) 		PF05368
(NmrA) 		4 GLY A  17
GLY A  14
VAL A  78
VAL A 190
 None
 0.73A 4c5nC-3e5mA:
7.6		 4c5nC-3e5mA:
23.01
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3fve DIAMINOPIMELATE
EPIMERASE

(Mycobacterium
tuberculosis) 		PF01678
(DAP_epimerase) 		4 GLY A 229
GLY A 227
VAL A 161
VAL A 259
 None
 0.85A 4c5nC-3fveA:
undetectable		 4c5nC-3fveA:
21.66
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3h3e UNCHARACTERIZED
PROTEIN TM1679

(Thermotoga
maritima) 		PF00753
(Lactamase_B) 		5 GLY A  64
ASP A  61
GLY A  33
HIS A 224
CYH A   7
 None
ZN  A 256 ( 4.5A)
None
None
None
 1.40A 4c5nC-3h3eA:
undetectable		 4c5nC-3h3eA:
23.90
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ihl CTP SYNTHASE 2

(Homo sapiens) 		PF06418
(CTP_synth_N) 		4 GLY A  17
GLY A  15
VAL A   6
VAL A 253
 ADP  A 300 (-3.4A)
ADP  A 300 (-3.4A)
None
None
 0.79A 4c5nC-3ihlA:
4.0		 4c5nC-3ihlA:
23.18
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3lq1 2-SUCCINYL-5-ENOLPYR
UVYL-6-HYDROXY-3-CYC
LOHEXENE-1-CARBOXYLA
TE SYNTHASE

(Listeria
monocytogenes) 		PF02775
(TPP_enzyme_C)
PF02776
(TPP_enzyme_N)
PF16582
(TPP_enzyme_M_2) 		4 GLY A 445
GLY A  65
VAL A 449
VAL A  74
 None
 0.89A 4c5nC-3lq1A:
undetectable		 4c5nC-3lq1A:
21.19
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3mqg LIPOPOLYSACCHARIDES
BIOSYNTHESIS
ACETYLTRANSFERASE

(Bordetella
petrii) 		PF00132
(Hexapep) 		4 GLY A  13
ASP A  11
GLY A  30
HIS A  27
 None
 0.86A 4c5nC-3mqgA:
undetectable		 4c5nC-3mqgA:
20.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3oth CALG1

(Micromonospora
echinospora) 		PF00201
(UDPGT)
PF03033
(Glyco_transf_28) 		4 GLY A 249
ASP A 245
GLY A 246
VAL A 254
 None
 0.79A 4c5nC-3othA:
6.5		 4c5nC-3othA:
22.96
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3owa ACYL-COA
DEHYDROGENASE

(Bacillus
anthracis) 		PF00441
(Acyl-CoA_dh_1)
PF02770
(Acyl-CoA_dh_M)
PF02771
(Acyl-CoA_dh_N) 		4 GLY A  87
GLY A  78
VAL A 124
HIS A 115
 None
 0.81A 4c5nC-3owaA:
undetectable		 4c5nC-3owaA:
19.50
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ptk BETA-GLUCOSIDASE
OS4BGLU12

(Oryza sativa) 		PF00232
(Glyco_hydro_1) 		4 GLY A  32
ASP A  62
GLY A  61
HIS A  49
 None
 0.78A 4c5nC-3ptkA:
2.1		 4c5nC-3ptkA:
19.72
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3rm5 HYDROXYMETHYLPYRIMID
INE/PHOSPHOMETHYLPYR
IMIDINE KINASE THI20

(Saccharomyces
cerevisiae) 		PF03070
(TENA_THI-4)
PF08543
(Phos_pyr_kin) 		7 GLY A  31
ASP A  33
GLY A  39
MET A 100
VAL A 128
HIS A 239
CYH A 243
 None
None
None
None
SO4  A   1 (-3.5A)
None
None
 0.41A 4c5nC-3rm5A:
32.8		 4c5nC-3rm5A:
22.94
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3u5u RAUCAFFRICINE-O-BETA
-D-GLUCOSIDASE

(Rauvolfia
serpentina) 		PF00232
(Glyco_hydro_1) 		4 GLY A  39
ASP A  69
GLY A  68
HIS A  56
 None
 0.74A 4c5nC-3u5uA:
2.5		 4c5nC-3u5uA:
20.58
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3un9 NLR FAMILY MEMBER X1

(Homo sapiens) 		PF13516
(LRR_6) 		4 GLY A 823
ASP A 821
GLY A 820
VAL A 842
 None
 0.89A 4c5nC-3un9A:
2.6		 4c5nC-3un9A:
21.04
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3vex O-CARBAMOYLTRANSFERA
SE TOBZ

(Streptoalloteichus
tenebrarius) 		PF02543
(Carbam_trans_N)
PF16861
(Carbam_trans_C) 		4 GLY A 522
ASP A 519
GLY A 518
VAL A 459
 None
 0.75A 4c5nC-3vexA:
undetectable		 4c5nC-3vexA:
19.05
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3vil BETA-GLUCOSIDASE

(Neotermes
koshunensis) 		PF00232
(Glyco_hydro_1) 		4 GLY A  48
ASP A  78
GLY A  77
HIS A  65
 None
 0.84A 4c5nC-3vilA:
undetectable		 4c5nC-3vilA:
19.65
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3wh7 BETA-GLUCOSIDASE

(metagenomes) 		PF00232
(Glyco_hydro_1) 		4 GLY A  23
ASP A  52
GLY A  51
HIS A  40
 None
 0.78A 4c5nC-3wh7A:
2.7		 4c5nC-3wh7A:
20.90
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3wq4 BETA-PRIMEVEROSIDASE

(Camellia
sinensis) 		PF00232
(Glyco_hydro_1) 		4 GLY A  56
ASP A  86
GLY A  85
HIS A  73
 None
 0.76A 4c5nC-3wq4A:
undetectable		 4c5nC-3wq4A:
20.08
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ad9 BETA-LACTAMASE-LIKE
PROTEIN 2

(Homo sapiens) 		PF00753
(Lactamase_B) 		5 GLY A  84
ASP A  81
GLY A  48
VAL A  75
HIS A 199
 None
ZN  A1000 (-2.8A)
None
None
ZN  A1000 (-3.3A)
 1.19A 4c5nC-4ad9A:
undetectable		 4c5nC-4ad9A:
23.71
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4cpd ALCOHOL
DEHYDROGENASE

(Thermus sp.
ATN1) 		PF00107
(ADH_zinc_N)
PF08240
(ADH_N) 		4 ASP A  41
GLY A  39
VAL A 268
HIS A  59
 None
NAD  A1407 (-3.3A)
NAD  A1407 (-4.1A)
ZN  A1200 (-3.4A)
 0.86A 4c5nC-4cpdA:
undetectable		 4c5nC-4cpdA:
20.73
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4e3z PUTATIVE
OXIDOREDUCTASE
PROTEIN

(Rhizobium etli) 		PF13561
(adh_short_C2) 		4 GLY A  15
GLY A  17
VAL A  45
CYH A  21
 None
 0.84A 4c5nC-4e3zA:
7.4		 4c5nC-4e3zA:
18.60
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4e8d GLYCOSYL HYDROLASE,
FAMILY 35

(Streptococcus
pneumoniae) 		PF01301
(Glyco_hydro_35) 		4 GLY A 208
ASP A 187
GLY A 188
VAL A 206
 None
 0.88A 4c5nC-4e8dA:
2.0		 4c5nC-4e8dA:
20.07
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4eb5 PROBABLE CYSTEINE
DESULFURASE 2

(Archaeoglobus
fulgidus) 		PF00266
(Aminotran_5) 		4 GLY A  61
GLY A  59
VAL A  63
VAL A 185
 None
 0.88A 4c5nC-4eb5A:
2.7		 4c5nC-4eb5A:
22.02
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4f9u CG32412

(Drosophila
melanogaster) 		PF04389
(Peptidase_M28) 		4 ASP A 168
GLY A 169
VAL A  86
HIS A  59
 None
 0.77A 4c5nC-4f9uA:
undetectable		 4c5nC-4f9uA:
18.27
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4gbj 6-PHOSPHOGLUCONATE
DEHYDROGENASE
NAD-BINDING

(Dyadobacter
fermentans) 		PF03446
(NAD_binding_2)
PF14833
(NAD_binding_11) 		4 GLY A  60
GLY A  88
VAL A  62
HIS A 108
 None
 0.82A 4c5nC-4gbjA:
6.4		 4c5nC-4gbjA:
22.19
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4gq1 NUP37

(Schizosaccharomyces
pombe) 		PF00400
(WD40) 		4 GLY A 204
GLY A 188
VAL A 191
HIS A 134
 None
 0.81A 4c5nC-4gq1A:
undetectable		 4c5nC-4gq1A:
18.47
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4gx8 DNA POLYMERASE III
SUBUNIT EPSILON,DNA
POLYMERASE III
SUBUNIT ALPHA

(Escherichia
coli) 		PF02811
(PHP) 		4 GLY A 104
GLY A 100
VAL A  25
VAL A  73
 None
 0.89A 4c5nC-4gx8A:
undetectable		 4c5nC-4gx8A:
24.34
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4gxp BETA-GLUCOSIDASE
CHIMERIC PROTEIN

(Thermotoga
maritima;
Trichoderma
reesei) 		PF00232
(Glyco_hydro_1) 		4 GLY A  30
ASP A  59
GLY A  58
HIS A  47
 None
 0.80A 4c5nC-4gxpA:
2.9		 4c5nC-4gxpA:
20.92
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4iwm UPF0135 PROTEIN
MJ0927

(Methanocaldococcus
jannaschii) 		PF01784
(NIF3) 		4 GLY A 180
ASP A 200
GLY A 199
VAL A 216
 None
 0.76A 4c5nC-4iwmA:
undetectable		 4c5nC-4iwmA:
21.19
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4jjp PHOSPHOMETHYLPYRIMID
INE KINASE

(Clostridioides
difficile) 		PF08543
(Phos_pyr_kin) 		4 ASP A  15
GLY A  21
MET A  82
VAL A 109
 None
 0.89A 4c5nC-4jjpA:
28.6		 4c5nC-4jjpA:
38.83
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4jnd CA(2+)/CALMODULIN-DE
PENDENT PROTEIN
KINASE PHOSPHATASE

(Caenorhabditis
elegans) 		PF00481
(PP2C) 		4 ASP A 340
GLY A 339
HIS A 204
CYH A 209
 None
 0.83A 4c5nC-4jndA:
undetectable		 4c5nC-4jndA:
21.57
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4m73 METHYLTRANSFERASE
MPPJ

(Streptomyces
hygroscopicus) 		PF13649
(Methyltransf_25) 		4 GLY A 185
ASP A 164
GLY A 187
VAL A 202
 None
SAH  A 401 ( 4.6A)
None
None
 0.78A 4c5nC-4m73A:
undetectable		 4c5nC-4m73A:
21.16
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4nwz FAD-DEPENDENT
PYRIDINE
NUCLEOTIDE-DISULFIDE
OXIDOREDUCTASE

(Caldalkalibacillus
thermarum) 		PF07992
(Pyr_redox_2) 		4 GLY A 164
GLY A 162
VAL A 203
VAL A 171
 None
 0.73A 4c5nC-4nwzA:
2.3		 4c5nC-4nwzA:
22.43
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4oh1 L-IDITOL
2-DEHYDROGENASE

([Clostridium]
scindens) 		PF00107
(ADH_zinc_N)
PF08240
(ADH_N) 		4 GLY A 182
GLY A 180
MET A 186
VAL A 189
 None
 0.89A 4c5nC-4oh1A:
7.0		 4c5nC-4oh1A:
22.62
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4peq RIBONUCLEASE/ANGIOGE
NIN INHIBITOR 1

(Bos taurus) 		PF13516
(LRR_6) 		4 GLY B 352
ASP B 350
GLY B 349
VAL B 372
 None
 0.88A 4c5nC-4peqB:
undetectable		 4c5nC-4peqB:
19.65
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4phb UNCHARACTERIZED
PROTEIN

(Ruminiclostridium
thermocellum) 		PF14262
(Cthe_2159) 		4 GLY A 194
ASP A 215
GLY A 216
VAL A 201
 None
GD  A 402 (-2.4A)
None
None
 0.81A 4c5nC-4phbA:
undetectable		 4c5nC-4phbA:
24.76
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ptx GLYCOSIDE HYDROLASE
FAMILY 1

(Halothermothrix
orenii) 		PF00232
(Glyco_hydro_1) 		4 GLY A  23
ASP A  52
GLY A  51
HIS A  40
 None
 0.72A 4c5nC-4ptxA:
2.9		 4c5nC-4ptxA:
20.26
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4qgs ALCOHOL
DEHYDROGENASE YQHD

(Escherichia
coli) 		PF00465
(Fe-ADH) 		4 ASP A 194
GLY A 191
VAL A 197
VAL A 339
 ZN  A 401 (-2.5A)
None
None
None
 0.78A 4c5nC-4qgsA:
5.7		 4c5nC-4qgsA:
23.96
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4qlj BETA-GLUCOSIDASE 7

(Oryza sativa) 		PF00232
(Glyco_hydro_1) 		4 GLY A  32
ASP A  61
GLY A  60
HIS A  49
 None
 0.74A 4c5nC-4qljA:
undetectable		 4c5nC-4qljA:
18.71
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4s1t URIDYLATE-SPECIFIC
ENDORIBONUCLEASE

(Human
coronavirus
229E) 		PF06471
(NSP11) 		4 GLY A 248
ASP A 240
GLY A 239
VAL A 282
 PO4  A 401 (-3.4A)
None
None
None
 0.78A 4c5nC-4s1tA:
undetectable		 4c5nC-4s1tA:
24.18
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4w8o LUCIFERASE-LIKE
ENZYMEAMP-COA-LIGASE

(Zophobas
atratus) 		PF00501
(AMP-binding) 		4 GLY A 323
GLY A 328
VAL A 379
HIS A 197
 P33  A 501 ( 4.2A)
P33  A 501 ( 4.0A)
None
None
 0.86A 4c5nC-4w8oA:
undetectable		 4c5nC-4w8oA:
21.88
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4xeu TRANSKETOLASE

(Pseudomonas
aeruginosa) 		PF00456
(Transketolase_N)
PF02779
(Transket_pyr)
PF02780
(Transketolase_C) 		4 GLY A  28
GLY A  67
VAL A  19
HIS A 100
 None
 0.68A 4c5nC-4xeuA:
undetectable		 4c5nC-4xeuA:
17.48
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ywr PUTATIVE
HYDROXYMETHYLPYRIMID
INE
KINASE/PHOSPHOMETHYL
PYRIMIDINE KINASE

(Acinetobacter
baumannii) 		PF08543
(Phos_pyr_kin) 		5 GLY A  18
ASP A  20
GLY A  26
MET A  87
VAL A 114
 PLP  A 300 ( 4.1A)
PLP  A 300 ( 4.8A)
PLP  A 300 (-3.4A)
PLP  A 300 ( 3.7A)
PLP  A 300 ( 4.8A)
 0.32A 4c5nC-4ywrA:
25.6		 4c5nC-4ywrA:
29.97
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4zwl BETAINE-ALDEHYDE
DEHYDROGENASE

(Staphylococcus
aureus) 		PF00171
(Aldedh) 		4 ASP A 218
GLY A 217
VAL A 229
HIS A 240
 NAD  A 501 (-4.5A)
NAD  A 501 (-3.4A)
None
NAD  A 501 (-4.1A)
 0.80A 4c5nC-4zwlA:
3.2		 4c5nC-4zwlA:
21.15
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5cg0 BETA-GLUCOSIDASE

(Spodoptera
frugiperda) 		PF00232
(Glyco_hydro_1) 		4 GLY A  42
ASP A  72
GLY A  71
HIS A  59
 None
 0.84A 4c5nC-5cg0A:
undetectable		 4c5nC-5cg0A:
19.80
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ep8 PYRIMIDINE-NUCLEOSID
E PHOSPHORYLASE

(Bacillus
subtilis) 		PF00591
(Glycos_transf_3)
PF02885
(Glycos_trans_3N)
PF07831
(PYNP_C) 		4 GLY A 262
ASP A 258
GLY A 264
VAL A 272
 GLY  A 262 ( 0.0A)
ASP  A 258 ( 0.6A)
GLY  A 264 ( 0.0A)
VAL  A 272 ( 0.6A)
 0.69A 4c5nC-5ep8A:
undetectable		 4c5nC-5ep8A:
23.06
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5gml GOLGI
REASSEMBLY-STACKING
PROTEIN 2

(Mus musculus) 		PF04495
(GRASP55_65) 		4 GLY A  28
GLY A  32
VAL A  84
VAL A  19
 None
 0.89A 4c5nC-5gmlA:
undetectable		 4c5nC-5gmlA:
21.03
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5gnx BETA-GLUCOSIDASE

(metagenome) 		PF00232
(Glyco_hydro_1) 		4 GLY A  28
ASP A  57
GLY A  56
HIS A  45
 None
 0.79A 4c5nC-5gnxA:
2.7		 4c5nC-5gnxA:
19.15
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5idi 1,4-BETA-D-GLUCAN
GLUCOHYDROLASE

(Thermotoga
neapolitana) 		PF00232
(Glyco_hydro_1) 		4 GLY A  21
ASP A  50
GLY A  49
HIS A  38
 None
 0.75A 4c5nC-5idiA:
2.3		 4c5nC-5idiA:
20.39
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5j44 SERINE PROTEASE SEPA
AUTOTRANSPORTER

(Shigella
flexneri) 		PF02395
(Peptidase_S6) 		4 GLY A 294
GLY A 279
VAL A 321
MET A 292
 None
 0.78A 4c5nC-5j44A:
undetectable		 4c5nC-5j44A:
14.43
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5jbo BETA-GLUCOSIDASE

(Trichoderma
harzianum) 		PF00232
(Glyco_hydro_1) 		4 GLY A  25
ASP A  54
GLY A  53
HIS A  42
 None
 0.79A 4c5nC-5jboA:
3.0		 4c5nC-5jboA:
19.88
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5jyg ACTIN-LIKE ATPASE

(Magnetospirillum
magneticum) 		PF06723
(MreB_Mbl) 		4 ASP A  17
GLY A 322
VAL A 315
HIS A  22
 MG  A 401 ( 4.6A)
None
None
None
 0.85A 4c5nC-5jygA:
undetectable		 4c5nC-5jygA:
24.92
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5l8x TETRAHYDROMETHANOPTE
RIN
S-METHYLTRANSFERASE
SUBUNIT A

(Methanocaldococcus
jannaschii) 		PF04208
(MtrA) 		4 GLY A 103
ASP A 101
GLY A 100
VAL A 123
 None
 0.76A 4c5nC-5l8xA:
3.1		 4c5nC-5l8xA:
19.20
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5m3q EUKARYOTIC
TRANSLATION
INITIATION FACTOR 6

(Chaetomium
thermophilum) 		PF01912
(eIF-6) 		4 GLY A  69
GLY A  65
VAL A 135
CYH A 110
 None
 0.78A 4c5nC-5m3qA:
undetectable		 4c5nC-5m3qA:
23.91
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ms3 KALLIKREIN-8

(Homo sapiens) 		no annotation 4 GLY A 226
GLY A 184
VAL A 181
VAL A 138
 None
 0.72A 4c5nC-5ms3A:
undetectable		 4c5nC-5ms3A:
15.71
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5n6y NITROGENASE
VANADIUM-IRON
PROTEIN BETA CHAIN

(Azotobacter
vinelandii) 		no annotation 4 ASP E 359
GLY E 358
VAL E 159
VAL E 338
 None
 0.86A 4c5nC-5n6yE:
undetectable		 4c5nC-5n6yE:
21.01
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5na7 PUTATIVE
DIPEPTIDYL-PEPTIDASE
III

(Bacteroides
thetaiotaomicron) 		no annotation 4 GLY A 441
ASP A 438
GLY A 437
HIS A 415
 None
 0.83A 4c5nC-5na7A:
undetectable		 4c5nC-5na7A:
18.10
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5o3w PEPTIDE CYCLASE 1

(Gypsophila
vaccaria) 		no annotation 4 GLY A 608
ASP A 606
GLY A 605
HIS A 523
 None
 0.82A 4c5nC-5o3wA:
2.2		 4c5nC-5o3wA:
14.66
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5o71 UBIQUITIN
CARBOXYL-TERMINAL
HYDROLASE 25

(Homo sapiens) 		no annotation 4 GLY A 301
GLY A 321
VAL A 296
MET A 319
 None
 0.88A 4c5nC-5o71A:
undetectable		 4c5nC-5o71A:
14.90
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ogz -

(-) 		no annotation 4 GLY A  23
ASP A  52
GLY A  51
HIS A  40
 None
 0.73A 4c5nC-5ogzA:
2.7		 4c5nC-5ogzA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5tnx ALCOHOL
DEHYDROGENASE
ZINC-BINDING DOMAIN
PROTEIN

(Burkholderia
ambifaria) 		PF00107
(ADH_zinc_N)
PF08240
(ADH_N) 		4 GLY A 203
GLY A 201
MET A 207
VAL A 210
 CIT  A 401 (-3.6A)
EDO  A 403 ( 4.8A)
None
None
 0.81A 4c5nC-5tnxA:
7.1		 4c5nC-5tnxA:
23.10
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5tul TETRACYCLINE
DESTRUCTASE TET(55)

(uncultured
bacterium) 		PF01494
(FAD_binding_3) 		4 GLY A 291
ASP A 289
GLY A 288
VAL A 337
 None
PO4  A 401 (-4.2A)
PO4  A 401 (-3.3A)
None
 0.88A 4c5nC-5tulA:
undetectable		 4c5nC-5tulA:
22.84
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5v1m U6 SNRNA
PHOSPHODIESTERASE

(Homo sapiens) 		PF09749
(HVSL) 		4 ASP A 217
GLY A 216
VAL A 110
CYH A 214
 None
None
CL  A 301 ( 4.4A)
None
 0.88A 4c5nC-5v1mA:
undetectable		 4c5nC-5v1mA:
18.86
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5w0a GLUCANASE

(Trichoderma
harzianum) 		no annotation 4 GLY A 113
ASP A 117
GLY A 116
VAL A  33
 GLY  A 113 ( 0.0A)
ASP  A 117 ( 0.5A)
GLY  A 116 ( 0.0A)
VAL  A  33 ( 0.6A)
 0.78A 4c5nC-5w0aA:
undetectable		 4c5nC-5w0aA:
14.45
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5w21 KLOTHO

(Homo sapiens) 		no annotation 4 GLY A  78
ASP A 123
GLY A 122
HIS A  95
 None
 0.88A 4c5nC-5w21A:
undetectable		 4c5nC-5w21A:
14.06
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5wva SHORT-CHAIN
DEHYDROGENASE

(Serratia
marcescens) 		no annotation 4 GLY A  22
ASP A 218
GLY A  20
VAL A  50
 None
 0.83A 4c5nC-5wvaA:
7.1		 4c5nC-5wvaA:
16.53
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5x15 PUTATIVE TRANSFERASE

(Streptomyces
coelicolor) 		PF03737
(RraA-like) 		4 GLY A 147
ASP A 119
GLY A 118
VAL A  77
 None
 0.80A 4c5nC-5x15A:
undetectable		 4c5nC-5x15A:
20.27
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5xse KHG/KDPG ALDOLASE

(Zymomonas
mobilis) 		no annotation 4 GLY A 123
ASP A 121
GLY A 119
VAL A 151
 None
 0.84A 4c5nC-5xseA:
2.9		 4c5nC-5xseA:
15.73