SIMILAR PATTERNS OF AMINO ACIDS FOR 4C5N_A_PXLA300_1
List of similar pattern of amino acids derived from ASSAM searchHit | Macromolecule/ Organism |
Pfam | Res. | Interface | HETATM | RMSD | Dali Z-score | Seq. Identity (%) | View | Dock | |
---|---|---|---|---|---|---|---|---|---|---|---|
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 1b74 | GLUTAMATE RACEMASE (Aquifexpyrophilus) |
PF01177(Asp_Glu_race) | 4 | GLY A 9ASP A 33GLY A 32VAL A 37 | None | 0.89A | 4c5nA-1b74A:5.5 | 4c5nA-1b74A:23.18 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 1c41 | LUMAZINE SYNTHASE (Magnaporthegrisea) |
PF00885(DMRL_synthase) | 4 | GLY A 181ASP A 179GLY A 177HIS A 174 | None | 0.83A | 4c5nA-1c41A:3.7 | 4c5nA-1c41A:21.20 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 1cbg | CYANOGENICBETA-GLUCOSIDASE (Trifoliumrepens) |
PF00232(Glyco_hydro_1) | 4 | GLY A 36ASP A 66GLY A 65HIS A 53 | None | 0.77A | 4c5nA-1cbgA:2.4 | 4c5nA-1cbgA:19.80 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 1cvr | GINGIPAIN R (Porphyromonasgingivalis) |
PF01364(Peptidase_C25)PF03785(Peptidase_C25_C) | 4 | GLY A 317ASP A 292GLY A 290HIS A 166 | None CA A 502 (-2.5A)None CA A 502 (-3.2A) | 0.86A | 4c5nA-1cvrA:2.9 | 4c5nA-1cvrA:21.27 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 1dwa | MYROSINASE MA1 (Sinapis alba) |
PF00232(Glyco_hydro_1) | 4 | GLY M 42ASP M 70GLY M 69HIS M 56 | None ZN M 923 (-2.2A)None ZN M 923 (-3.2A) | 0.81A | 4c5nA-1dwaM:3.2 | 4c5nA-1dwaM:20.39 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 1gaj | HIGH-AFFINITYBRANCHED CHAIN AMINOACID TRANSPORTATP-BINDING PROTEIN (Methanocaldococcusjannaschii) |
PF00005(ABC_tran) | 4 | ASP A 34GLY A 33VAL A 30MET A 174 | None | 0.89A | 4c5nA-1gajA:undetectable | 4c5nA-1gajA:21.40 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 1jxi | PHOSPHOMETHYLPYRIMIDINE KINASE (Salmonellaenterica) |
PF08543(Phos_pyr_kin) | 7 | GLY A 11ASP A 13GLY A 19VAL A 42MET A 80HIS A 209CYH A 213 | HMH A2001 (-3.6A)NoneHMH A2001 ( 3.8A)NoneHMH A2001 ( 4.5A)SO4 A2005 (-4.3A)HMH A2001 (-3.6A) | 0.55A | 4c5nA-1jxiA:31.5 | 4c5nA-1jxiA:28.81 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 1k7h | ALKALINE PHOSPHATASE (Pandalusborealis) |
PF00245(Alk_phosphatase) | 4 | GLY A 311ASP A 37GLY A 36HIS A 357 | None ZN A 478 ( 2.1A)None ZN A 478 (-3.1A) | 0.86A | 4c5nA-1k7hA:undetectable | 4c5nA-1k7hA:21.37 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 1kcz | BETA-METHYLASPARTASE (Clostridiumtetanomorphum) |
PF05034(MAAL_N)PF07476(MAAL_C) | 4 | GLY A 244ASP A 277GLY A 241VAL A 278 | None | 0.89A | 4c5nA-1kczA:undetectable | 4c5nA-1kczA:21.16 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 1kz1 | 6,7-DIMETHYL-8-RIBITYLLUMAZINE SYNTHASE (Schizosaccharomycespombe) |
PF00885(DMRL_synthase) | 4 | GLY A 147ASP A 145GLY A 143HIS A 140 | None | 0.86A | 4c5nA-1kz1A:3.2 | 4c5nA-1kz1A:21.40 | ||
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target. | 1ub0 | PHOSPHOMETHYLPYRIMIDINE KINASE (Thermusthermophilus) |
PF08543(Phos_pyr_kin) | 5 | GLY A 9ASP A 11GLY A 17HIS A 206CYH A 210 | None | 0.39A | 4c5nA-1ub0A:34.0 | 4c5nA-1ub0A:36.12 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 1v02 | DHURRINASE (Sorghum bicolor) |
PF00232(Glyco_hydro_1) | 4 | GLY A 42ASP A 72GLY A 71HIS A 59 | None | 0.88A | 4c5nA-1v02A:2.3 | 4c5nA-1v02A:18.72 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 1v8b | ADENOSYLHOMOCYSTEINASE (Plasmodiumfalciparum) |
PF00670(AdoHcyase_NAD)PF05221(AdoHcyase) | 4 | GLY A 269ASP A 267GLY A 266VAL A 236 | NoneNAD A 501 (-4.4A)NAD A 501 (-3.5A)None | 0.78A | 4c5nA-1v8bA:5.1 | 4c5nA-1v8bA:17.31 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 1wcg | THIOGLUCOSIDASE (Brevicorynebrassicae) |
PF00232(Glyco_hydro_1) | 4 | GLY A 22ASP A 52GLY A 51HIS A 39 | None | 0.93A | 4c5nA-1wcgA:2.0 | 4c5nA-1wcgA:20.43 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 1x3l | HYPOTHETICAL PROTEINPH0495 (Pyrococcushorikoshii) |
PF05161(MOFRL)PF13660(DUF4147) | 4 | GLY A 208ASP A 213GLY A 178HIS A 172 | None | 0.93A | 4c5nA-1x3lA:5.9 | 4c5nA-1x3lA:20.22 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 1yp4 | GLUCOSE-1-PHOSPHATEADENYLYLTRANSFERASESMALL SUBUNIT (Solanumtuberosum) |
PF00483(NTP_transferase) | 4 | GLY A 390GLY A 392VAL A 387CYH A 395 | None | 0.88A | 4c5nA-1yp4A:undetectable | 4c5nA-1yp4A:20.31 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 1yq2 | BETA-GALACTOSIDASE (Arthrobactersp. C2-2) |
PF02836(Glyco_hydro_2_C)PF02837(Glyco_hydro_2_N)PF02929(Bgal_small_N)PF16353(DUF4981) | 4 | GLY A 577ASP A 575GLY A 574HIS A 973 | None | 0.91A | 4c5nA-1yq2A:3.4 | 4c5nA-1yq2A:13.56 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 1zef | ALKALINE PHOSPHATASE (Homo sapiens) |
PF00245(Alk_phosphatase) | 4 | GLY A 312ASP A 42GLY A 41HIS A 358 | None ZN A 902 ( 2.1A)None ZN A 902 (-3.2A) | 0.86A | 4c5nA-1zefA:undetectable | 4c5nA-1zefA:20.61 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 2a22 | VACUOLAR PROTEINSORTING 29 (Cryptosporidiumparvum) |
PF12850(Metallophos_2) | 4 | ASP A 14GLY A 13HIS A 101CYH A 42 | None | 0.73A | 4c5nA-2a22A:undetectable | 4c5nA-2a22A:22.11 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 2bwg | GMP REDUCTASE I (Homo sapiens) |
PF00478(IMPDH) | 4 | GLY A 195GLY A 181VAL A 160CYH A 186 | None K A1339 (-4.8A)None5GP A1340 ( 3.4A) | 0.89A | 4c5nA-2bwgA:undetectable | 4c5nA-2bwgA:22.04 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 2cyc | TYROSYL-TRNASYNTHETASE (Pyrococcushorikoshii) |
PF00579(tRNA-synt_1b) | 4 | GLY A 51GLY A 55MET A 102HIS A 36 | None | 0.89A | 4c5nA-2cycA:2.0 | 4c5nA-2cycA:21.04 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 2ef4 | ARGINASE (Thermusthermophilus) |
PF00491(Arginase) | 4 | GLY A 167ASP A 119VAL A 221HIS A 97 | None | 0.93A | 4c5nA-2ef4A:4.6 | 4c5nA-2ef4A:20.46 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 2glf | PROBABLE M18-FAMILYAMINOPEPTIDASE 1 (Thermotogamaritima) |
PF02127(Peptidase_M18) | 4 | GLY A 420ASP A 328GLY A 327HIS A 94 | None MN A5001 (-2.2A)None MN A5001 (-3.6A) | 0.81A | 4c5nA-2glfA:undetectable | 4c5nA-2glfA:23.27 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 2hro | PHOSPHOENOLPYRUVATE-PROTEINPHOSPHOTRANSFERASE (Staphylococcuscarnosus) |
PF00391(PEP-utilizers)PF02896(PEP-utilizers_C)PF05524(PEP-utilisers_N) | 4 | ASP A 522GLY A 501VAL A 270HIS A 494 | None | 0.93A | 4c5nA-2hroA:3.3 | 4c5nA-2hroA:18.78 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 2hru | PHOSPHORIBOSYLFORMYLGLYCINAMIDINESYNTHASE II (Thermotogamaritima) |
PF00586(AIRS)PF02769(AIRS_C)PF16904(PurL_C) | 4 | ASP A 107GLY A 136VAL A 152HIS A 375 | None | 0.92A | 4c5nA-2hruA:undetectable | 4c5nA-2hruA:18.27 | ||
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target. | 2i5b | PHOSPHOMETHYLPYRIMIDINE KINASE (Bacillussubtilis) |
PF08543(Phos_pyr_kin) | 7 | GLY A 11ASP A 13GLY A 19VAL A 42MET A 82HIS A 212CYH A 216 | None | 0.40A | 4c5nA-2i5bA:41.7 | 4c5nA-2i5bA:49.63 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 2id0 | EXORIBONUCLEASE 2 (Escherichiacoli) |
PF00575(S1)PF00773(RNB)PF08206(OB_RNB) | 4 | GLY A 24ASP A 58VAL A 26HIS A 135 | None | 0.81A | 4c5nA-2id0A:undetectable | 4c5nA-2id0A:18.59 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 2j7c | BETA-GLUCOSIDASE A (Thermotogamaritima) |
PF00232(Glyco_hydro_1) | 4 | GLY A 23ASP A 52GLY A 51HIS A 40 | None | 0.80A | 4c5nA-2j7cA:2.2 | 4c5nA-2j7cA:21.32 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 2jfe | CYTOSOLICBETA-GLUCOSIDASE (Homo sapiens) |
PF00232(Glyco_hydro_1) | 4 | GLY X 20ASP X 50GLY X 49HIS X 37 | None | 0.91A | 4c5nA-2jfeX:3.4 | 4c5nA-2jfeX:19.41 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 2k5p | THIAMINE-BIOSYNTHESIS PROTEIN (Geobactermetallireducens) |
PF02597(ThiS) | 4 | ASP A 58GLY A 57VAL A 54MET A 1 | None | 0.87A | 4c5nA-2k5pA:undetectable | 4c5nA-2k5pA:15.33 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 2r2d | ZN-DEPENDENTHYDROLASES (Agrobacteriumfabrum) |
PF00753(Lactamase_B) | 4 | GLY A 118ASP A 115GLY A 60HIS A 259 | NonePO4 A 279 (-2.9A)None ZN A 277 (-3.2A) | 0.79A | 4c5nA-2r2dA:undetectable | 4c5nA-2r2dA:22.26 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 2uut | RNA-DIRECTED RNAPOLYMERASE (Sapporo virus) |
PF00680(RdRP_1) | 4 | GLY A 186ASP A 188GLY A 119HIS A 144 | None | 0.92A | 4c5nA-2uutA:undetectable | 4c5nA-2uutA:21.33 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 2uvf | EXOPOLYGALACTURONASE (Yersiniaenterocolitica) |
PF00295(Glyco_hydro_28)PF12708(Pectate_lyase_3) | 4 | GLY A 464ASP A 462GLY A 436CYH A 404 | None | 0.58A | 4c5nA-2uvfA:undetectable | 4c5nA-2uvfA:18.91 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 2wu5 | SUCCINATEDEHYDROGENASEFLAVOPROTEIN SUBUNIT (Escherichiacoli) |
PF00890(FAD_binding_2)PF02910(Succ_DH_flav_C) | 4 | GLY A 204GLY A 206MET A 356CYH A 353 | None | 0.69A | 4c5nA-2wu5A:undetectable | 4c5nA-2wu5A:17.60 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 2wya | HYDROXYMETHYLGLUTARYL-COA SYNTHASE,MITOCHONDRIAL (Homo sapiens) |
PF01154(HMG_CoA_synt_N)PF08540(HMG_CoA_synt_C) | 4 | GLY A 212GLY A 195VAL A 61MET A 381 | None | 0.88A | 4c5nA-2wyaA:undetectable | 4c5nA-2wyaA:21.52 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 2xdr | BETAINE ALDEHYDEDEHYDROGENASE (Pseudomonasaeruginosa) |
PF00171(Aldedh) | 4 | GLY A 364ASP A 360GLY A 361VAL A 358 | None | 0.92A | 4c5nA-2xdrA:4.1 | 4c5nA-2xdrA:21.29 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 2zii | VACUOLAR PROTEINSORTING-ASSOCIATEDPROTEIN 74 (Saccharomycescerevisiae) |
PF05719(GPP34) | 4 | GLY A 261GLY A 258VAL A 264CYH A 99 | None | 0.88A | 4c5nA-2ziiA:undetectable | 4c5nA-2ziiA:23.13 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3ahx | BETA-GLUCOSIDASE A (Clostridiumcellulovorans) |
PF00232(Glyco_hydro_1) | 4 | GLY A 23ASP A 52GLY A 51HIS A 40 | None | 0.75A | 4c5nA-3ahxA:2.9 | 4c5nA-3ahxA:20.70 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3b40 | PROBABLE DIPEPTIDASE (Pseudomonasaeruginosa) |
PF01244(Peptidase_M19) | 4 | GLY A 396ASP A 390GLY A 394VAL A 296 | None | 0.93A | 4c5nA-3b40A:4.2 | 4c5nA-3b40A:23.24 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3e2d | ALKALINE PHOSPHATASE (Vibrio sp.G15-21) |
PF00245(Alk_phosphatase) | 4 | GLY A 269ASP A 12GLY A 11HIS A 316 | None ZN A 602 (-2.2A)None ZN A 602 ( 3.2A) | 0.89A | 4c5nA-3e2dA:undetectable | 4c5nA-3e2dA:22.26 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3gs6 | BETA-HEXOSAMINIDASE (Vibrio cholerae) |
PF00933(Glyco_hydro_3) | 4 | GLY A 121ASP A 119GLY A 166HIS A 161 | NoneNoneNoneNP6 A 341 (-3.6A) | 0.93A | 4c5nA-3gs6A:2.3 | 4c5nA-3gs6A:21.57 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3h3e | UNCHARACTERIZEDPROTEIN TM1679 (Thermotogamaritima) |
PF00753(Lactamase_B) | 5 | GLY A 64ASP A 61GLY A 33HIS A 224CYH A 7 | None ZN A 256 ( 4.5A)NoneNoneNone | 1.40A | 4c5nA-3h3eA:undetectable | 4c5nA-3h3eA:23.90 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3j4s | FTSZ/TUBULIN-RELATEDPROTEIN (Bacillusthuringiensis) |
PF00091(Tubulin) | 4 | GLY A 278GLY A 378VAL A 208HIS A 313 | None | 0.91A | 4c5nA-3j4sA:3.6 | 4c5nA-3j4sA:20.86 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3ld8 | BIFUNCTIONALARGININE DEMETHYLASEANDLYSYL-HYDROXYLASEJMJD6 (Homo sapiens) |
PF02373(JmjC) | 4 | GLY A 192ASP A 189GLY A 269HIS A 273 | None FE A 601 (-3.3A)None FE A 601 (-3.7A) | 0.92A | 4c5nA-3ld8A:undetectable | 4c5nA-3ld8A:20.11 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3mi6 | ALPHA-GALACTOSIDASE (Lactobacillusbrevis) |
PF02065(Melibiase)PF16874(Glyco_hydro_36C)PF16875(Glyco_hydro_36N) | 4 | ASP A 474GLY A 410VAL A 522HIS A 403 | None | 0.81A | 4c5nA-3mi6A:2.4 | 4c5nA-3mi6A:17.06 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3ml3 | OUTER MEMBRANEPROTEIN ICSAAUTOTRANSPORTER (Shigellaflexneri) |
PF03212(Pertactin) | 4 | GLY A 592GLY A 620VAL A 594MET A 590 | None | 0.90A | 4c5nA-3ml3A:undetectable | 4c5nA-3ml3A:18.56 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3mqg | LIPOPOLYSACCHARIDESBIOSYNTHESISACETYLTRANSFERASE (Bordetellapetrii) |
PF00132(Hexapep) | 4 | GLY A 13ASP A 11GLY A 30HIS A 27 | None | 0.84A | 4c5nA-3mqgA:undetectable | 4c5nA-3mqgA:20.00 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3nnk | UREIDOGLYCINE-GLYOXYLATEAMINOTRANSFERASE (Klebsiellapneumoniae) |
PF00266(Aminotran_5) | 4 | GLY A 122ASP A 316GLY A 315VAL A 124 | None | 0.87A | 4c5nA-3nnkA:5.3 | 4c5nA-3nnkA:21.21 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3ptk | BETA-GLUCOSIDASEOS4BGLU12 (Oryza sativa) |
PF00232(Glyco_hydro_1) | 4 | GLY A 32ASP A 62GLY A 61HIS A 49 | None | 0.79A | 4c5nA-3ptkA:undetectable | 4c5nA-3ptkA:19.72 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3rm5 | HYDROXYMETHYLPYRIMIDINE/PHOSPHOMETHYLPYRIMIDINE KINASE THI20 (Saccharomycescerevisiae) |
PF03070(TENA_THI-4)PF08543(Phos_pyr_kin) | 6 | GLY A 31ASP A 33GLY A 39MET A 100HIS A 239CYH A 243 | None | 0.39A | 4c5nA-3rm5A:33.0 | 4c5nA-3rm5A:22.94 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3u5u | RAUCAFFRICINE-O-BETA-D-GLUCOSIDASE (Rauvolfiaserpentina) |
PF00232(Glyco_hydro_1) | 4 | GLY A 39ASP A 69GLY A 68HIS A 56 | None | 0.77A | 4c5nA-3u5uA:2.9 | 4c5nA-3u5uA:20.58 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3vil | BETA-GLUCOSIDASE (Neotermeskoshunensis) |
PF00232(Glyco_hydro_1) | 4 | GLY A 48ASP A 78GLY A 77HIS A 65 | None | 0.92A | 4c5nA-3vilA:undetectable | 4c5nA-3vilA:19.65 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3vrb | FLAVOPROTEIN SUBUNITOF COMPLEX II (Ascaris suum) |
PF00890(FAD_binding_2)PF02910(Succ_DH_flav_C) | 4 | GLY A 53GLY A 445HIS A 425CYH A 448 | None | 0.89A | 4c5nA-3vrbA:undetectable | 4c5nA-3vrbA:19.01 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3wbh | ALKALINE PHOSPHATASE (Halomonas sp.#593) |
PF00245(Alk_phosphatase) | 4 | GLY A 265ASP A 12GLY A 11HIS A 312 | None ZN A 505 ( 2.1A)None ZN A 505 (-3.1A) | 0.92A | 4c5nA-3wbhA:undetectable | 4c5nA-3wbhA:21.28 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3wh7 | BETA-GLUCOSIDASE (metagenomes) |
PF00232(Glyco_hydro_1) | 4 | GLY A 23ASP A 52GLY A 51HIS A 40 | None | 0.80A | 4c5nA-3wh7A:undetectable | 4c5nA-3wh7A:20.90 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3wq4 | BETA-PRIMEVEROSIDASE (Camelliasinensis) |
PF00232(Glyco_hydro_1) | 4 | GLY A 56ASP A 86GLY A 85HIS A 73 | None | 0.77A | 4c5nA-3wq4A:undetectable | 4c5nA-3wq4A:20.08 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4ad9 | BETA-LACTAMASE-LIKEPROTEIN 2 (Homo sapiens) |
PF00753(Lactamase_B) | 4 | GLY A 84ASP A 81GLY A 48HIS A 199 | None ZN A1000 (-2.8A)None ZN A1000 (-3.3A) | 0.92A | 4c5nA-4ad9A:undetectable | 4c5nA-4ad9A:23.71 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4bbw | SIALIDASE(NEURAMINIDASE) (Bacteroidesthetaiotaomicron) |
PF13088(BNR_2)PF14873(BNR_assoc_N) | 4 | GLY A 237ASP A 235VAL A 222MET A 251 | None | 0.84A | 4c5nA-4bbwA:undetectable | 4c5nA-4bbwA:20.18 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4e8d | GLYCOSYL HYDROLASE,FAMILY 35 (Streptococcuspneumoniae) |
PF01301(Glyco_hydro_35) | 4 | GLY A 208ASP A 187GLY A 188VAL A 206 | None | 0.94A | 4c5nA-4e8dA:2.3 | 4c5nA-4e8dA:20.07 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4fuk | METHIONINEAMINOPEPTIDASE (Trypanosomabrucei) |
PF00557(Peptidase_M24) | 4 | GLY A 288ASP A 222GLY A 221CYH A 134 | None ZN A 402 ( 2.3A)NoneNone | 0.90A | 4c5nA-4fukA:undetectable | 4c5nA-4fukA:22.25 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4gbj | 6-PHOSPHOGLUCONATEDEHYDROGENASENAD-BINDING (Dyadobacterfermentans) |
PF03446(NAD_binding_2)PF14833(NAD_binding_11) | 4 | GLY A 60GLY A 88VAL A 62HIS A 108 | None | 0.87A | 4c5nA-4gbjA:6.1 | 4c5nA-4gbjA:22.19 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4ge0 | UNCHARACTERIZEDPROTEIN C22E12.03C (Schizosaccharomycespombe) |
PF01965(DJ-1_PfpI) | 4 | GLY A 82ASP A 13GLY A 78CYH A 111 | None | 0.88A | 4c5nA-4ge0A:undetectable | 4c5nA-4ge0A:23.24 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4gq1 | NUP37 (Schizosaccharomycespombe) |
PF00400(WD40) | 4 | GLY A 204GLY A 188VAL A 191HIS A 134 | None | 0.75A | 4c5nA-4gq1A:undetectable | 4c5nA-4gq1A:18.47 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4gxp | BETA-GLUCOSIDASECHIMERIC PROTEIN (Thermotogamaritima;Trichodermareesei) |
PF00232(Glyco_hydro_1) | 4 | GLY A 30ASP A 59GLY A 58HIS A 47 | None | 0.83A | 4c5nA-4gxpA:2.9 | 4c5nA-4gxpA:20.92 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4i14 | RIBOFLAVINBIOSYNTHESIS PROTEINRIBBA (Mycobacteriumtuberculosis) |
PF00925(GTP_cyclohydro2)PF00926(DHBP_synthase) | 5 | GLY A 271ASP A 268GLY A 278VAL A 269HIS A 261 | None | 1.46A | 4c5nA-4i14A:undetectable | 4c5nA-4i14A:21.13 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4imm | OUTER MEMBRANEASSEMBLY LIPOPROTEINYFGL (Moraxellacatarrhalis) |
PF13360(PQQ_2) | 4 | ASP A 216GLY A 217VAL A 191HIS A 220 | None | 0.86A | 4c5nA-4immA:undetectable | 4c5nA-4immA:22.85 | ||
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target. | 4jjp | PHOSPHOMETHYLPYRIMIDINE KINASE (Clostridioidesdifficile) |
PF08543(Phos_pyr_kin) | 4 | ASP A 15GLY A 21MET A 82CYH A 213 | None | 0.91A | 4c5nA-4jjpA:28.7 | 4c5nA-4jjpA:38.83 | ||
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target. | 4jjp | PHOSPHOMETHYLPYRIMIDINE KINASE (Clostridioidesdifficile) |
PF08543(Phos_pyr_kin) | 4 | GLY A 13ASP A 15GLY A 21CYH A 213 | None | 0.64A | 4c5nA-4jjpA:28.7 | 4c5nA-4jjpA:38.83 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4jnd | CA(2+)/CALMODULIN-DEPENDENT PROTEINKINASE PHOSPHATASE (Caenorhabditiselegans) |
PF00481(PP2C) | 4 | ASP A 340GLY A 339HIS A 204CYH A 209 | None | 0.78A | 4c5nA-4jndA:2.4 | 4c5nA-4jndA:21.57 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4kp2 | HOMOACONITASE LARGESUBUNIT (Methanocaldococcusjannaschii) |
PF00330(Aconitase) | 4 | GLY A 132ASP A 117GLY A 116HIS A 62 | None | 0.87A | 4c5nA-4kp2A:undetectable | 4c5nA-4kp2A:20.57 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4mo1 | ANTITERMINATIONPROTEIN Q (Escherichiavirus Lambda) |
PF03589(Antiterm) | 4 | GLY A 123GLY A 151VAL A 189CYH A 147 | None ZN A 301 ( 4.8A)None ZN A 301 (-2.3A) | 0.93A | 4c5nA-4mo1A:undetectable | 4c5nA-4mo1A:22.26 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4pfm | 4-HYDROXY-TETRAHYDRODIPICOLINATESYNTHASE (Shewanellabenthica) |
PF00701(DHDPS) | 4 | GLY A 76GLY A 102MET A 100HIS A 118 | None | 0.92A | 4c5nA-4pfmA:2.1 | 4c5nA-4pfmA:24.29 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4ptx | GLYCOSIDE HYDROLASEFAMILY 1 (Halothermothrixorenii) |
PF00232(Glyco_hydro_1) | 4 | GLY A 23ASP A 52GLY A 51HIS A 40 | None | 0.78A | 4c5nA-4ptxA:2.5 | 4c5nA-4ptxA:20.26 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4q6k | BNR/ASP-BOX REPEATPROTEIN (Bacteroidescaccae) |
PF13088(BNR_2)PF14873(BNR_assoc_N) | 4 | GLY A 253ASP A 251VAL A 238MET A 267 | None | 0.84A | 4c5nA-4q6kA:undetectable | 4c5nA-4q6kA:19.84 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4qlj | BETA-GLUCOSIDASE 7 (Oryza sativa) |
PF00232(Glyco_hydro_1) | 4 | GLY A 32ASP A 61GLY A 60HIS A 49 | None | 0.76A | 4c5nA-4qljA:2.1 | 4c5nA-4qljA:18.71 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4r4z | PNGF-II (Elizabethkingiameningoseptica) |
PF09112(N-glycanase_N)PF09113(N-glycanase_C) | 4 | GLY A 351ASP A 250GLY A 249VAL A 388 | None | 0.90A | 4c5nA-4r4zA:undetectable | 4c5nA-4r4zA:19.32 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4rg1 | C9ORF114 (Homo sapiens) |
PF02598(Methyltrn_RNA_3) | 4 | GLY A 202ASP A 218GLY A 204HIS A 243 | None | 0.91A | 4c5nA-4rg1A:2.0 | 4c5nA-4rg1A:21.81 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4rkc | AROMATIC AMINO ACIDAMINOTRANSFERASE (Psychrobactersp. B6) |
PF00155(Aminotran_1_2) | 4 | GLY A 218VAL A 311MET A 221CYH A 180 | NoneNoneNO3 A 404 (-4.8A)None | 0.84A | 4c5nA-4rkcA:4.9 | 4c5nA-4rkcA:22.00 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4rl4 | GTP CYCLOHYDROLASE-2 (Helicobacterpylori) |
PF00925(GTP_cyclohydro2) | 4 | GLY A 62ASP A 59GLY A 58HIS A 52 | None | 0.92A | 4c5nA-4rl4A:3.0 | 4c5nA-4rl4A:19.86 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4tu3 | VACUOLAR PROTEINSORTING-ASSOCIATEDPROTEIN 74 (Saccharomycescerevisiae) |
PF05719(GPP34) | 4 | GLY A 261GLY A 258VAL A 264CYH A 99 | None | 0.90A | 4c5nA-4tu3A:undetectable | 4c5nA-4tu3A:23.12 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4ywr | PUTATIVEHYDROXYMETHYLPYRIMIDINEKINASE/PHOSPHOMETHYLPYRIMIDINE KINASE (Acinetobacterbaumannii) |
PF08543(Phos_pyr_kin) | 4 | GLY A 18ASP A 20GLY A 26MET A 87 | PLP A 300 ( 4.1A)PLP A 300 ( 4.8A)PLP A 300 (-3.4A)PLP A 300 ( 3.7A) | 0.26A | 4c5nA-4ywrA:25.6 | 4c5nA-4ywrA:29.97 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4zo3 | ACYLHOMOSERINELACTONASE (Chryseobacteriumsp. StRB126) |
PF00753(Lactamase_B) | 4 | GLY A 152ASP A 149GLY A 112HIS A 305 | None ZN A 402 ( 2.6A)None ZN A 402 ( 3.3A) | 0.91A | 4c5nA-4zo3A:undetectable | 4c5nA-4zo3A:23.30 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 5cg0 | BETA-GLUCOSIDASE (Spodopterafrugiperda) |
PF00232(Glyco_hydro_1) | 4 | GLY A 42ASP A 72GLY A 71HIS A 59 | None | 0.91A | 4c5nA-5cg0A:undetectable | 4c5nA-5cg0A:19.80 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 5gnx | BETA-GLUCOSIDASE (metagenome) |
PF00232(Glyco_hydro_1) | 4 | GLY A 28ASP A 57GLY A 56HIS A 45 | None | 0.82A | 4c5nA-5gnxA:2.9 | 4c5nA-5gnxA:19.15 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 5hx0 | UNCHARACTERIZEDPROTEIN DFER_1899 (Dyadobacterfermentans) |
PF13088(BNR_2) | 4 | GLY A 281ASP A 284GLY A 283HIS A 329 | None | 0.75A | 4c5nA-5hx0A:undetectable | 4c5nA-5hx0A:22.59 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 5idi | 1,4-BETA-D-GLUCANGLUCOHYDROLASE (Thermotoganeapolitana) |
PF00232(Glyco_hydro_1) | 4 | GLY A 21ASP A 50GLY A 49HIS A 38 | None | 0.78A | 4c5nA-5idiA:3.4 | 4c5nA-5idiA:20.39 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 5ila | PROTEASE DO-LIKE 9 (Arabidopsisthaliana) |
PF13365(Trypsin_2) | 4 | GLY A 156GLY A 279VAL A 131HIS A 169 | None | 0.92A | 4c5nA-5ilaA:undetectable | 4c5nA-5ilaA:23.64 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 5imw | INTERMEDILYSIN (Streptococcusintermedius) |
PF01289(Thiol_cytolysin)PF17440(Thiol_cytolys_C) | 4 | GLY A 515ASP A 426GLY A 427HIS A 465 | None | 0.89A | 4c5nA-5imwA:undetectable | 4c5nA-5imwA:20.41 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 5j44 | SERINE PROTEASE SEPAAUTOTRANSPORTER (Shigellaflexneri) |
PF02395(Peptidase_S6) | 4 | GLY A 294GLY A 279VAL A 321MET A 292 | None | 0.83A | 4c5nA-5j44A:undetectable | 4c5nA-5j44A:14.43 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 5jbo | BETA-GLUCOSIDASE (Trichodermaharzianum) |
PF00232(Glyco_hydro_1) | 4 | GLY A 25ASP A 54GLY A 53HIS A 42 | None | 0.80A | 4c5nA-5jboA:3.0 | 4c5nA-5jboA:19.88 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 5na7 | PUTATIVEDIPEPTIDYL-PEPTIDASEIII (Bacteroidesthetaiotaomicron) |
no annotation | 4 | GLY A 441ASP A 438GLY A 437HIS A 415 | None | 0.83A | 4c5nA-5na7A:2.2 | 4c5nA-5na7A:18.10 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 5o3w | PEPTIDE CYCLASE 1 (Gypsophilavaccaria) |
no annotation | 4 | GLY A 608ASP A 606GLY A 605HIS A 523 | None | 0.83A | 4c5nA-5o3wA:undetectable | 4c5nA-5o3wA:14.66 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 5o71 | UBIQUITINCARBOXYL-TERMINALHYDROLASE 25 (Homo sapiens) |
no annotation | 4 | GLY A 301GLY A 321VAL A 296MET A 319 | None | 0.86A | 4c5nA-5o71A:undetectable | 4c5nA-5o71A:14.90 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 5o9w | THEBAINE6-O-DEMETHYLASE (Papaversomniferum) |
no annotation | 4 | GLY A 242ASP A 240GLY A 279HIS A 295 | None NI A 401 ( 2.5A)None NI A 401 ( 3.3A) | 0.94A | 4c5nA-5o9wA:undetectable | 4c5nA-5o9wA:15.41 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 5ogz | - (-) |
no annotation | 4 | GLY A 23ASP A 52GLY A 51HIS A 40 | None | 0.80A | 4c5nA-5ogzA:3.2 | 4c5nA-5ogzA:undetectable | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 5osh | VACUOLAR PROTEINSORTING-ASSOCIATEDPROTEIN 29 (Homo sapiens) |
no annotation | 4 | ASP A 8GLY A 7HIS A 86CYH A 36 | None | 0.90A | 4c5nA-5oshA:undetectable | 4c5nA-5oshA:15.58 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 5vc2 | SERINEHYDROXYMETHYLTRANSFERASE (Helicobacterpylori) |
PF00464(SHMT) | 4 | GLY A 170GLY A 196VAL A 201CYH A 217 | None | 0.89A | 4c5nA-5vc2A:5.1 | 4c5nA-5vc2A:18.89 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 5w21 | KLOTHO (Homo sapiens) |
no annotation | 4 | GLY A 78ASP A 123GLY A 122HIS A 95 | None | 0.94A | 4c5nA-5w21A:undetectable | 4c5nA-5w21A:14.06 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 6fqc | BIFUNCTIONALARGININE DEMETHYLASEANDLYSYL-HYDROXYLASEJMJD6 (Homo sapiens) |
no annotation | 4 | GLY A 192ASP A 189GLY A 269HIS A 273 | NA A 508 ( 4.5A) MN A 501 ( 2.6A) NA A 508 (-4.2A) MN A 501 ( 3.1A) | 0.89A | 4c5nA-6fqcA:undetectable | 4c5nA-6fqcA:14.40 |