SIMILAR PATTERNS OF AMINO ACIDS FOR 4C5L_A_UEGA300_1

List of similar pattern of amino acids derived from ASSAM search

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click link on the last column to view superposed patterns of amino acids in NGL viewer)
(Note that only 3-12 residue patterns can be used for ASSAM searches)
Filter list by:
Hit Macromolecule/
Organism		 Pfam Res. Interface HETATM RMSD Dali Z-score Seq. Identity (%) View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1d1t ALCOHOL
DEHYDROGENASE CLASS
IV SIGMA CHAIN

(Homo sapiens) 		PF00107
(ADH_zinc_N)
PF08240
(ADH_N) 		5 GLY A 204
ALA A 182
GLY A 179
VAL A 197
CYH A 211
 None
 1.19A 4c5lA-1d1tA:
4.8		 4c5lA-1d1tA:
24.86
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1dih DIHYDRODIPICOLINATE
REDUCTASE

(Escherichia
coli) 		PF01113
(DapB_N)
PF05173
(DapB_C) 		5 GLY A  14
ALA A  11
GLY A  12
VAL A  62
HIS A  88
 NDP  A 301 ( 4.9A)
None
NDP  A 301 ( 3.1A)
None
None
 1.30A 4c5lA-1dihA:
7.6		 4c5lA-1dihA:
24.21
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1eg1 ENDOGLUCANASE I

(Trichoderma
reesei) 		PF00840
(Glyco_hydro_7) 		5 GLY A 169
ALA A 164
GLY A 154
MET A 150
VAL A 314
 None
 1.24A 4c5lA-1eg1A:
undetectable		 4c5lA-1eg1A:
23.77
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1gq4 EZRIN-RADIXIN-MOESIN
BINDING
PHOSPHOPROTEIN-50

(Homo sapiens) 		PF00595
(PDZ) 		5 ALA A  51
GLY A  52
VAL A  42
VAL A  90
CYH A  15
 None
None
CL  A1102 ( 4.9A)
None
None
 1.34A 4c5lA-1gq4A:
undetectable		 4c5lA-1gq4A:
12.81
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1jnf SEROTRANSFERRIN

(Oryctolagus
cuniculus) 		PF00405
(Transferrin) 		5 GLY A 123
ASP A  63
ALA A  64
GLY A  65
VAL A 323
 None
FE  A 702 ( 3.1A)
None
None
None
 1.31A 4c5lA-1jnfA:
undetectable		 4c5lA-1jnfA:
17.01
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1jxi PHOSPHOMETHYLPYRIMID
INE KINASE

(Salmonella
enterica) 		PF08543
(Phos_pyr_kin) 		5 ALA A  18
VAL A  49
VAL A 107
HIS A 209
CYH A 213
 HMH  A2001 ( 4.0A)
None
HMH  A2001 ( 4.7A)
SO4  A2005 (-4.3A)
HMH  A2001 (-3.6A)
 1.26A 4c5lA-1jxiA:
32.2		 4c5lA-1jxiA:
28.81
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1jxi PHOSPHOMETHYLPYRIMID
INE KINASE

(Salmonella
enterica) 		PF08543
(Phos_pyr_kin) 		9 GLY A  11
ASP A  13
ALA A  18
GLY A  19
VAL A  42
MET A  80
VAL A 107
HIS A 209
CYH A 213
 HMH  A2001 (-3.6A)
None
HMH  A2001 ( 4.0A)
HMH  A2001 ( 3.8A)
None
HMH  A2001 ( 4.5A)
HMH  A2001 ( 4.7A)
SO4  A2005 (-4.3A)
HMH  A2001 (-3.6A)
 0.52A 4c5lA-1jxiA:
32.2		 4c5lA-1jxiA:
28.81
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1m64 FLAVOCYTOCHROME C3

(Shewanella
frigidimarina) 		PF00890
(FAD_binding_2)
PF14537
(Cytochrom_c3_2) 		5 GLY A 451
ASP A 457
ALA A 460
GLY A 458
VAL A 388
 None
 1.35A 4c5lA-1m64A:
2.7		 4c5lA-1m64A:
21.13
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1mzj BETA-KETOACYLSYNTHAS
E III

(Streptomyces
sp. R1128) 		PF08541
(ACP_syn_III_C)
PF08545
(ACP_syn_III) 		5 ALA A 325
GLY A 326
VAL A 233
VAL A 294
CYH A 125
 None
 0.97A 4c5lA-1mzjA:
undetectable		 4c5lA-1mzjA:
20.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1nvm ACETALDEHYDE
DEHYDROGENASE
(ACYLATING)

(Pseudomonas sp.
CF600) 		PF01118
(Semialdhyde_dh)
PF09290
(AcetDehyd-dimer) 		5 GLY B 240
ALA B 280
GLY B 279
LYS B  22
HIS B 282
 None
 1.28A 4c5lA-1nvmB:
5.5		 4c5lA-1nvmB:
22.49
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1q2e EXOCELLOBIOHYDROLASE
I

(Trichoderma
reesei) 		PF00840
(Glyco_hydro_7) 		5 GLY A 170
ALA A 165
GLY A 153
MET A 149
VAL A 361
 None
 1.34A 4c5lA-1q2eA:
undetectable		 4c5lA-1q2eA:
21.02
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1q9h CELLOBIOHYDROLASE I
CATALYTIC DOMAIN

(Rasamsonia
emersonii) 		PF00840
(Glyco_hydro_7) 		5 GLY A 167
ALA A 162
GLY A 150
MET A 146
VAL A 365
 None
 1.32A 4c5lA-1q9hA:
undetectable		 4c5lA-1q9hA:
22.25
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1rfv PYRIDOXAL KINASE

(Ovis aries) 		PF08543
(Phos_pyr_kin) 		5 GLY A 122
ALA A  23
GLY A  20
VAL A  14
VAL A 231
 None
 1.39A 4c5lA-1rfvA:
26.5		 4c5lA-1rfvA:
26.09
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1td2 PYRIDOXAMINE KINASE

(Escherichia
coli) 		PF08543
(Phos_pyr_kin) 		5 GLY A 223
ALA A  17
GLY A 221
VAL A 114
CYH A 122
 None
PXL  A 288 ( 3.9A)
PXL  A 288 ( 4.2A)
None
PXL  A 288 (-2.0A)
 1.34A 4c5lA-1td2A:
27.9		 4c5lA-1td2A:
23.81
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1tdk L-AMINO ACID OXIDASE

(Gloydius halys) 		PF01593
(Amino_oxidase) 		5 GLY A  45
ALA A 476
GLY A 473
VAL A  38
VAL A  51
 None
 1.22A 4c5lA-1tdkA:
3.0		 4c5lA-1tdkA:
20.84
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1ub0 PHOSPHOMETHYLPYRIMID
INE KINASE

(Thermus
thermophilus) 		PF08543
(Phos_pyr_kin) 		7 GLY A   9
ASP A  11
ALA A  16
GLY A  17
VAL A 105
HIS A 206
CYH A 210
 None
 0.42A 4c5lA-1ub0A:
33.6		 4c5lA-1ub0A:
36.12
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1uxi MALATE DEHYDROGENASE

(Chloroflexus
aurantiacus) 		PF00056
(Ldh_1_N)
PF02866
(Ldh_1_C) 		5 GLY A 274
ALA A 239
GLY A 272
VAL A 114
VAL A 269
 None
 1.22A 4c5lA-1uxiA:
3.6		 4c5lA-1uxiA:
24.71
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1v8b ADENOSYLHOMOCYSTEINA
SE

(Plasmodium
falciparum) 		PF00670
(AdoHcyase_NAD)
PF05221
(AdoHcyase) 		5 GLY A 269
ASP A 267
GLY A 266
VAL A 236
CYH A 292
 None
NAD  A 501 (-4.4A)
NAD  A 501 (-3.5A)
None
NAD  A 501 (-3.4A)
 1.13A 4c5lA-1v8bA:
4.4		 4c5lA-1v8bA:
17.31
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1w5f CELL DIVISION
PROTEIN FTSZ

(Thermotoga
maritima) 		PF00091
(Tubulin)
PF12327
(FtsZ_C) 		5 GLY A 120
ALA A  91
GLY A  88
VAL A  53
VAL A 126
 G2P  A 500 (-3.4A)
None
None
None
None
 1.32A 4c5lA-1w5fA:
2.9		 4c5lA-1w5fA:
24.19
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1wl4 ACETYL-COENZYME A
ACETYLTRANSFERASE 2

(Homo sapiens) 		PF00108
(Thiolase_N)
PF02803
(Thiolase_C) 		5 GLY A  58
ALA A 260
GLY A 117
VAL A  70
MET A 119
 None
 1.42A 4c5lA-1wl4A:
undetectable		 4c5lA-1wl4A:
22.92
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1z3v CELLULASE

(Phanerochaete
chrysosporium) 		PF00840
(Glyco_hydro_7) 		5 GLY A 167
ALA A 162
GLY A 150
MET A 146
VAL A 358
 None
 1.29A 4c5lA-1z3vA:
undetectable		 4c5lA-1z3vA:
21.60
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2abq FRUCTOSE 1-PHOSPHATE
KINASE

(Bacillus
halodurans) 		PF00294
(PfkB) 		5 GLY A 248
ALA A 275
GLY A 276
VAL A  45
CYH A 286
 None
 0.99A 4c5lA-2abqA:
20.9		 4c5lA-2abqA:
21.30
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2abq FRUCTOSE 1-PHOSPHATE
KINASE

(Bacillus
halodurans) 		PF00294
(PfkB) 		5 GLY A 248
ALA A 275
GLY A 276
VAL A 252
CYH A 286
 None
 1.32A 4c5lA-2abqA:
20.9		 4c5lA-2abqA:
21.30
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2beo LISTERIOLYSIN
REGULATORY PROTEIN

(Listeria
monocytogenes) 		PF13545
(HTH_Crp_2) 		5 GLY A 138
ASP A 133
ALA A 218
GLY A 141
CYH A 144
 None
 1.43A 4c5lA-2beoA:
undetectable		 4c5lA-2beoA:
20.21
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2bkl PROLYL ENDOPEPTIDASE

(Myxococcus
xanthus) 		PF00326
(Peptidase_S9)
PF02897
(Peptidase_S9_N) 		5 GLY A 536
ALA A 542
GLY A 540
VAL A 553
HIS A 510
 None
 1.35A 4c5lA-2bklA:
undetectable		 4c5lA-2bklA:
18.77
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2bru NAD(P)
TRANSHYDROGENASE
SUBUNIT ALPHA

(Escherichia
coli) 		PF01262
(AlaDh_PNT_C)
PF05222
(AlaDh_PNT_N) 		5 GLY A1208
ALA A1180
GLY A1182
VAL A1204
VAL A1168
 None
 1.34A 4c5lA-2bruA:
5.4		 4c5lA-2bruA:
23.04
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2d0o DIOL
DEHYDRATASE-REACTIVA
TING FACTOR LARGE
SUBUNIT

(Klebsiella
oxytoca) 		PF08841
(DDR) 		5 GLY A  81
ASP A 440
ALA A 416
GLY A 417
VAL A  83
 None
None
ADP  A1001 (-3.3A)
None
None
 1.31A 4c5lA-2d0oA:
undetectable		 4c5lA-2d0oA:
21.43
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2ewo PUTATIVE AGMATINE
DEIMINASE

(Streptococcus
mutans) 		PF04371
(PAD_porph) 		5 GLY A  19
ASP A 168
GLY A 169
MET A  17
CYH A 204
 None
 0.93A 4c5lA-2ewoA:
undetectable		 4c5lA-2ewoA:
21.69
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2f4l ACETAMIDASE,
PUTATIVE

(Thermotoga
maritima) 		PF03069
(FmdA_AmdA) 		5 GLY A  60
ALA A 167
GLY A 166
VAL A 200
VAL A  23
 None
 1.29A 4c5lA-2f4lA:
undetectable		 4c5lA-2f4lA:
23.01
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2i5b PHOSPHOMETHYLPYRIMID
INE KINASE

(Bacillus
subtilis) 		PF08543
(Phos_pyr_kin) 		9 GLY A  11
ASP A  13
ALA A  18
GLY A  19
VAL A  42
MET A  82
VAL A 109
HIS A 212
CYH A 216
 None
 0.43A 4c5lA-2i5bA:
39.8		 4c5lA-2i5bA:
49.63
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2iy9 SUBA

(Escherichia
coli) 		PF00082
(Peptidase_S8) 		5 GLY A 239
ASP A 184
ALA A 186
GLY A 185
VAL A 181
 None
 1.40A 4c5lA-2iy9A:
4.1		 4c5lA-2iy9A:
21.81
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2m0u NA(+)/H(+) EXCHANGE
REGULATORY COFACTOR
NHE-RF1

(Homo sapiens) 		PF00595
(PDZ) 		5 ALA A  51
GLY A  52
VAL A  42
VAL A  90
CYH A  15
 None
 1.26A 4c5lA-2m0uA:
undetectable		 4c5lA-2m0uA:
16.46
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2p10 MLL9387 PROTEIN

(Mesorhizobium
japonicum) 		PF09370
(PEP_hydrolase) 		5 GLY A  31
ALA A 258
GLY A 257
VAL A  52
VAL A 187
 None
CL  A 290 (-4.0A)
CL  A 289 (-3.6A)
None
None
 1.27A 4c5lA-2p10A:
3.5		 4c5lA-2p10A:
22.29
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2rdx MANDELATE
RACEMASE/MUCONATE
LACTONIZING ENZYME,
PUTATIVE

(Roseovarius
nubinhibens) 		PF02746
(MR_MLE_N)
PF13378
(MR_MLE_C) 		5 GLY A 331
ALA A 300
GLY A 297
VAL A 352
VAL A  35
 None
 1.22A 4c5lA-2rdxA:
2.2		 4c5lA-2rdxA:
21.20
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2rfz CELLULOSE
1,4-BETA-CELLOBIOSID
ASE

(Melanocarpus
albomyces) 		PF00840
(Glyco_hydro_7) 		5 GLY A 170
ALA A 165
GLY A 153
MET A 149
VAL A 360
 None
 1.43A 4c5lA-2rfzA:
undetectable		 4c5lA-2rfzA:
20.80
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2vsp PDZ
DOMAIN-CONTAINING
PROTEIN 1

(Homo sapiens) 		PF00595
(PDZ) 		5 ALA A 415
GLY A 416
VAL A 406
VAL A 454
CYH A 379
 None
 1.32A 4c5lA-2vspA:
undetectable		 4c5lA-2vspA:
17.27
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2wtz UDP-N-ACETYLMURAMOYL
-L-ALANYL-D-GLUTAMAT
E--2,6-DIAMINOPIMELA
TE LIGASE

(Mycobacterium
tuberculosis) 		PF01225
(Mur_ligase)
PF02875
(Mur_ligase_C)
PF08245
(Mur_ligase_M) 		5 GLY A  99
ASP A  76
GLY A  75
VAL A  72
VAL A 119
 None
 1.29A 4c5lA-2wtzA:
6.8		 4c5lA-2wtzA:
20.04
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2yok EXOGLUCANASE 1

(Trichoderma
harzianum) 		PF00840
(Glyco_hydro_7) 		5 GLY A 183
ALA A 178
GLY A 166
MET A 162
VAL A 374
 None
 1.35A 4c5lA-2yokA:
undetectable		 4c5lA-2yokA:
21.20
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2z1a 5'-NUCLEOTIDASE

(Thermus
thermophilus) 		PF00149
(Metallophos)
PF02872
(5_nucleotid_C) 		5 GLY A  82
GLY A 114
VAL A  84
MET A 111
VAL A 136
 None
 1.23A 4c5lA-2z1aA:
undetectable		 4c5lA-2z1aA:
19.40
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3cj8 2,3,4,5-TETRAHYDROPY
RIDINE-2,6-DICARBOXY
LATE
N-ACETYLTRANSFERASE

(Enterococcus
faecalis) 		PF00132
(Hexapep)
PF08503
(DapH_N)
PF14602
(Hexapep_2) 		5 GLY A 153
ALA A 119
GLY A 135
VAL A 163
VAL A 132
 CL  A 304 (-3.5A)
None
CL  A 304 (-4.0A)
None
None
 1.23A 4c5lA-3cj8A:
undetectable		 4c5lA-3cj8A:
22.70
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3d1r FRUCTOSE-1,6-BISPHOS
PHATASE CLASS II
GLPX

(Escherichia
coli) 		PF03320
(FBPase_glpX) 		5 GLY A  77
ASP A  50
GLY A  75
VAL A  80
VAL A  47
 None
 1.42A 4c5lA-3d1rA:
undetectable		 4c5lA-3d1rA:
23.03
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3dwd ADP-RIBOSYLATION
FACTOR
GTPASE-ACTIVATING
PROTEIN 1

(Homo sapiens) 		PF01412
(ArfGap) 		5 GLY A  38
GLY A  79
VAL A  33
MET A  75
VAL A  13
 None
 1.37A 4c5lA-3dwdA:
undetectable		 4c5lA-3dwdA:
16.96
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ehf SENSOR KINASE (YOCF
PROTEIN)

(Bacillus
subtilis) 		PF07730
(HisKA_3) 		5 GLY A 358
ASP A 321
ALA A 300
GLY A 322
CYH A 303
 None
 1.33A 4c5lA-3ehfA:
undetectable		 4c5lA-3ehfA:
23.46
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3fao NON-STRUCTURAL
PROTEIN

(Porcine
reproductive
and respiratory
syndrome virus) 		PF05579
(Peptidase_S32) 		5 GLY A  23
ALA A  37
GLY A 119
VAL A  15
HIS A  39
 None
None
None
None
PO4  A 205 (-4.0A)
 1.43A 4c5lA-3faoA:
undetectable		 4c5lA-3faoA:
20.85
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3fao NON-STRUCTURAL
PROTEIN

(Porcine
reproductive
and respiratory
syndrome virus) 		PF05579
(Peptidase_S32) 		5 GLY A  23
ALA A 118
GLY A 119
VAL A  15
HIS A  39
 None
PO4  A 205 ( 3.8A)
None
None
PO4  A 205 (-4.0A)
 1.30A 4c5lA-3faoA:
undetectable		 4c5lA-3faoA:
20.85
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3h3e UNCHARACTERIZED
PROTEIN TM1679

(Thermotoga
maritima) 		PF00753
(Lactamase_B) 		5 GLY A  64
ASP A  61
GLY A  33
HIS A 224
CYH A   7
 None
ZN  A 256 ( 4.5A)
None
None
None
 1.32A 4c5lA-3h3eA:
undetectable		 4c5lA-3h3eA:
23.90
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3juc AIG2-LIKE
DOMAIN-CONTAINING
PROTEIN 1

(Homo sapiens) 		PF06094
(GGACT) 		5 ASP A  22
ALA A  24
GLY A  23
VAL A  19
MET A  74
 None
 1.16A 4c5lA-3jucA:
undetectable		 4c5lA-3jucA:
19.26
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3n5f N-CARBAMOYL-L-AMINO
ACID HYDROLASE

(Geobacillus
stearothermophilus) 		PF01546
(Peptidase_M20)
PF07687
(M20_dimer) 		5 GLY A  91
ALA A  97
GLY A  94
VAL A 372
CYH A 391
 CO  A 410 ( 4.8A)
None
None
None
None
 1.09A 4c5lA-3n5fA:
undetectable		 4c5lA-3n5fA:
20.85
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3o3p MANNOSYL-3-PHOSPHOGL
YCERATE SYNTHASE

(Rubrobacter
xylanophilus) 		PF00535
(Glycos_transf_2) 		5 GLY A 226
ASP A 117
ALA A 112
GLY A 114
VAL A 323
 None
None
None
GDD  A 340 (-3.2A)
None
 1.19A 4c5lA-3o3pA:
undetectable		 4c5lA-3o3pA:
22.03
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3o47 ADP-RIBOSYLATION
FACTOR
GTPASE-ACTIVATING
PROTEIN 1,
ADP-RIBOSYLATION
FACTOR 1

(Homo sapiens) 		PF00025
(Arf)
PF01412
(ArfGap) 		5 GLY A  38
GLY A  79
VAL A  33
MET A  75
VAL A  13
 None
 1.40A 4c5lA-3o47A:
4.3		 4c5lA-3o47A:
20.99
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3q54 OUTER MEMBRANE
ASSEMBLY LIPOPROTEIN
YFGL

(Escherichia
coli) 		PF13360
(PQQ_2) 		5 GLY A 344
ASP A 363
ALA A 382
GLY A 366
VAL A 362
 None
 1.27A 4c5lA-3q54A:
undetectable		 4c5lA-3q54A:
24.87
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3rm5 HYDROXYMETHYLPYRIMID
INE/PHOSPHOMETHYLPYR
IMIDINE KINASE THI20

(Saccharomyces
cerevisiae) 		PF03070
(TENA_THI-4)
PF08543
(Phos_pyr_kin) 		5 ALA A  38
VAL A  69
VAL A 128
HIS A 239
CYH A 243
 None
None
SO4  A   1 (-3.5A)
None
None
 1.01A 4c5lA-3rm5A:
32.3		 4c5lA-3rm5A:
22.94
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3rm5 HYDROXYMETHYLPYRIMID
INE/PHOSPHOMETHYLPYR
IMIDINE KINASE THI20

(Saccharomyces
cerevisiae) 		PF03070
(TENA_THI-4)
PF08543
(Phos_pyr_kin) 		8 GLY A  31
ASP A  33
ALA A  38
GLY A  39
MET A 100
VAL A 128
HIS A 239
CYH A 243
 None
None
None
None
None
SO4  A   1 (-3.5A)
None
None
 0.37A 4c5lA-3rm5A:
32.3		 4c5lA-3rm5A:
22.94
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3s5n 4-HYDROXY-2-OXOGLUTA
RATE ALDOLASE,
MITOCHONDRIAL

(Homo sapiens) 		PF00701
(DHDPS) 		5 GLY A  37
ALA A 221
GLY A 238
VAL A 250
CYH A 240
 None
 1.07A 4c5lA-3s5nA:
3.3		 4c5lA-3s5nA:
22.19
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3sgh SUSD HOMOLOG

(Bacteroides
thetaiotaomicron) 		PF12741
(SusD-like) 		5 ASP A 196
GLY A 201
VAL A 195
VAL A 122
CYH A 203
 None
 1.06A 4c5lA-3sghA:
undetectable		 4c5lA-3sghA:
20.27
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3tju GRANZYME H

(Homo sapiens) 		PF00089
(Trypsin) 		5 GLY A  46
ALA A  57
GLY A 198
VAL A  33
HIS A  59
 None
 1.44A 4c5lA-3tjuA:
undetectable		 4c5lA-3tjuA:
21.18
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3u24 PUTATIVE LIPOPROTEIN

(Shewanella
oneidensis) 		PF05960
(DUF885) 		5 GLY A 546
ALA A 461
GLY A 459
VAL A 491
HIS A 433
 None
ZN  A 595 ( 4.2A)
None
None
ZN  A 595 (-3.3A)
 1.12A 4c5lA-3u24A:
undetectable		 4c5lA-3u24A:
18.65
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3un9 NLR FAMILY MEMBER X1

(Homo sapiens) 		PF13516
(LRR_6) 		5 GLY A 823
ASP A 821
ALA A 847
GLY A 820
VAL A 842
 None
 1.11A 4c5lA-3un9A:
undetectable		 4c5lA-3un9A:
21.04
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3vth HYDROGENASE
MATURATION FACTOR

(Caldanaerobacter
subterraneus) 		PF00708
(Acylphosphatase)
PF01300
(Sua5_yciO_yrdC)
PF07503
(zf-HYPF) 		5 GLY A 598
ASP A 507
GLY A 508
VAL A 594
HIS A 484
 AP2  A 806 (-3.2A)
FE  A 807 ( 3.1A)
AP2  A 806 (-3.0A)
None
None
 1.37A 4c5lA-3vthA:
3.0		 4c5lA-3vthA:
16.78
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3wh9 ENDO-BETA-1,4-MANNAN
ASE

(Aspergillus
niger) 		PF00150
(Cellulase) 		5 ASP A  58
ALA A 120
GLY A 116
VAL A 109
HIS A  73
 None
 1.36A 4c5lA-3wh9A:
3.2		 4c5lA-3wh9A:
24.10
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ad9 BETA-LACTAMASE-LIKE
PROTEIN 2

(Homo sapiens) 		PF00753
(Lactamase_B) 		5 GLY A  84
ASP A  81
GLY A  48
VAL A  75
HIS A 199
 None
ZN  A1000 (-2.8A)
None
None
ZN  A1000 (-3.3A)
 1.13A 4c5lA-4ad9A:
undetectable		 4c5lA-4ad9A:
23.71
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4bf5 ALANINE RACEMASE

(Aeromonas
hydrophila) 		PF00842
(Ala_racemase_C)
PF01168
(Ala_racemase_N) 		5 GLY A 399
ASP A  76
ALA A  77
GLY A  79
VAL A  46
 None
 1.05A 4c5lA-4bf5A:
2.4		 4c5lA-4bf5A:
21.33
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4c5n PHOSPHOMETHYLPYRIMID
INE KINASE

(Staphylococcus
aureus) 		PF08543
(Phos_pyr_kin) 		9 GLY A  11
ASP A  13
ALA A  18
GLY A  19
VAL A  42
MET A  80
VAL A 107
HIS A 210
CYH A 214
 PXL  A 300 (-3.9A)
PXL  A 300 (-4.3A)
PXL  A 300 ( 4.0A)
PXL  A 300 (-3.6A)
PXL  A 300 ( 4.5A)
PXL  A 300 ( 4.2A)
None
ACP  A 500 (-4.3A)
PXL  A 300 ( 2.9A)
 0.26A 4c5lA-4c5nA:
46.2		 4c5lA-4c5nA:
100.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4csi CELLULASE

(Humicola grisea) 		PF00840
(Glyco_hydro_7) 		5 GLY A 171
ALA A 166
GLY A 154
MET A 150
VAL A 366
 None
 1.27A 4c5lA-4csiA:
undetectable		 4c5lA-4csiA:
22.15
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4czb NA(+)/H(+)
ANTIPORTER 1

(Methanocaldococcus
jannaschii) 		PF00999
(Na_H_Exchanger) 		5 GLY A 259
ALA A  74
GLY A 255
VAL A 222
CYH A 277
 None
 1.33A 4c5lA-4czbA:
undetectable		 4c5lA-4czbA:
22.40
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4czt CBL-INTERACTING
SERINE/THREONINE-PRO
TEIN KINASE 23

(Arabidopsis
thaliana) 		PF00069
(Pkinase) 		5 GLY A 113
ASP A 163
ALA A 167
GLY A 166
VAL A 111
 CPS  A1316 (-3.9A)
SO4  A1318 (-4.6A)
None
None
SO4  A1318 (-3.8A)
 1.13A 4c5lA-4cztA:
undetectable		 4c5lA-4cztA:
21.02
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4dyj BROAD SPECIFICITY
AMINO ACID RACEMASE

(Pseudomonas
putida) 		PF00842
(Ala_racemase_C)
PF01168
(Ala_racemase_N) 		5 GLY A 400
ASP A  77
ALA A  78
GLY A  80
VAL A  48
 None
 1.02A 4c5lA-4dyjA:
undetectable		 4c5lA-4dyjA:
24.63
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4fin ETTA (YJJK) ABCF
FAMILY PROTEIN

(Escherichia
coli) 		PF00005
(ABC_tran)
PF12848
(ABC_tran_Xtn) 		5 ALA A 350
GLY A 349
VAL A 323
HIS A 510
CYH A 493
 None
 0.87A 4c5lA-4finA:
undetectable		 4c5lA-4finA:
20.71
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4haq GH7 FAMILY PROTEIN

(Limnoria
quadripunctata) 		PF00840
(Glyco_hydro_7) 		5 GLY A 191
ALA A 186
GLY A 174
MET A 170
VAL A 386
 None
 1.28A 4c5lA-4haqA:
undetectable		 4c5lA-4haqA:
22.04
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4i14 RIBOFLAVIN
BIOSYNTHESIS PROTEIN
RIBBA

(Mycobacterium
tuberculosis) 		PF00925
(GTP_cyclohydro2)
PF00926
(DHBP_synthase) 		5 GLY A 271
ASP A 268
GLY A 278
VAL A 269
HIS A 261
 None
 1.42A 4c5lA-4i14A:
undetectable		 4c5lA-4i14A:
21.13
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ihe THNT PROTEIN

(Streptomyces
cattleya) 		PF03576
(Peptidase_S58) 		5 GLY A 161
ALA A 116
GLY A 113
VAL A 165
VAL A 138
 None
 1.25A 4c5lA-4iheA:
undetectable		 4c5lA-4iheA:
20.33
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4izg MANDELATE
RACEMASE/MUCONATE
LACTONIZING ENZYME,
N-TERMINAL DOMAIN
PROTEIN

(Paracoccus
denitrificans) 		PF02746
(MR_MLE_N)
PF13378
(MR_MLE_C) 		5 GLY A 264
GLY A 262
VAL A 251
CYH A 283
CYH A 260
 None
 1.20A 4c5lA-4izgA:
2.4		 4c5lA-4izgA:
20.72
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4jjp PHOSPHOMETHYLPYRIMID
INE KINASE

(Clostridioides
difficile) 		PF08543
(Phos_pyr_kin) 		6 ASP A  15
ALA A  20
GLY A  21
MET A  82
VAL A 109
CYH A 213
 None
 1.01A 4c5lA-4jjpA:
28.7		 4c5lA-4jjpA:
38.83
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4jjp PHOSPHOMETHYLPYRIMID
INE KINASE

(Clostridioides
difficile) 		PF08543
(Phos_pyr_kin) 		6 GLY A  13
ASP A  15
ALA A  20
GLY A  21
VAL A 109
CYH A 213
 None
 0.82A 4c5lA-4jjpA:
28.7		 4c5lA-4jjpA:
38.83
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4jq9 DIHYDROLIPOYL
DEHYDROGENASE

(Escherichia
coli) 		PF02852
(Pyr_redox_dim)
PF07992
(Pyr_redox_2) 		5 GLY A  18
ALA A 331
GLY A 328
VAL A  11
CYH A  25
 None
 1.28A 4c5lA-4jq9A:
3.5		 4c5lA-4jq9A:
23.29
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4m9p FILAMIN-A

(Homo sapiens) 		PF00630
(Filamin) 		5 GLY A 583
ASP A 596
ALA A 595
GLY A 585
VAL A 645
 None
 1.05A 4c5lA-4m9pA:
undetectable		 4c5lA-4m9pA:
22.86
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4mgx FILAMIN-C

(Homo sapiens) 		PF00630
(Filamin) 		5 GLY A 578
ASP A 591
ALA A 590
GLY A 580
VAL A 640
 None
 1.05A 4c5lA-4mgxA:
undetectable		 4c5lA-4mgxA:
24.10
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4pk1 CHIMERA PROTEIN OF
OUTER MEMBRANE
PROTEIN ASSEMBLY
FACTORS BAMA AND
BAMB

(Escherichia
coli) 		PF07244
(POTRA)
PF13360
(PQQ_2) 		5 GLY A1344
ASP A1363
ALA A1382
GLY A1366
VAL A1362
 None
 1.20A 4c5lA-4pk1A:
undetectable		 4c5lA-4pk1A:
18.72
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4u98 MALTOKINASE

(Mycolicibacterium
vanbaalenii) 		PF01636
(APH) 		5 GLY A 390
ALA A 240
GLY A 238
VAL A 394
HIS A 175
 None
 1.36A 4c5lA-4u98A:
undetectable		 4c5lA-4u98A:
20.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4v20 CELLOBIOHYDROLASE

(Aspergillus
fumigatus) 		PF00840
(Glyco_hydro_7) 		5 GLY A 170
ALA A 165
GLY A 153
MET A 149
VAL A 368
 None
 1.32A 4c5lA-4v20A:
undetectable		 4c5lA-4v20A:
19.30
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ywr PUTATIVE
HYDROXYMETHYLPYRIMID
INE
KINASE/PHOSPHOMETHYL
PYRIMIDINE KINASE

(Acinetobacter
baumannii) 		PF08543
(Phos_pyr_kin) 		6 GLY A  18
ASP A  20
ALA A  25
GLY A  26
MET A  87
VAL A 114
 PLP  A 300 ( 4.1A)
PLP  A 300 ( 4.8A)
PLP  A 300 (-2.9A)
PLP  A 300 (-3.4A)
PLP  A 300 ( 3.7A)
PLP  A 300 ( 4.8A)
 0.36A 4c5lA-4ywrA:
26.5		 4c5lA-4ywrA:
29.97
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4zpx ATP-DEPENDENT
PROTEASE LON

(Thermococcus
onnurineus) 		PF01078
(Mg_chelatase)
PF13654
(AAA_32) 		5 ASP A 404
ALA A 392
GLY A 389
VAL A 405
VAL A 343
 None
 1.35A 4c5lA-4zpxA:
undetectable		 4c5lA-4zpxA:
21.46
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4zzp CELLULOSE
1,4-BETA-CELLOBIOSID
ASE

(Dictyostelium
purpureum) 		PF00840
(Glyco_hydro_7) 		5 GLY A 169
ALA A 164
GLY A 152
MET A 148
VAL A 367
 None
 1.33A 4c5lA-4zzpA:
undetectable		 4c5lA-4zzpA:
20.99
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4zzq CELLULOSE
1,4-BETA-CELLOBIOSID
ASE

(Dictyostelium
discoideum) 		PF00840
(Glyco_hydro_7) 		5 GLY A 169
ALA A 164
GLY A 152
MET A 148
VAL A 367
 None
 1.29A 4c5lA-4zzqA:
undetectable		 4c5lA-4zzqA:
19.82
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5aid MEP2

(Candida
albicans) 		PF00909
(Ammonium_transp) 		5 GLY A 313
ALA A 292
GLY A 293
VAL A 348
CYH A 320
 None
 1.43A 4c5lA-5aidA:
undetectable		 4c5lA-5aidA:
22.15
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5amp CELLOBIOHYDROLASE I

(Galactomyces
candidus) 		PF00840
(Glyco_hydro_7) 		5 GLY A 170
ALA A 165
GLY A 153
MET A 149
VAL A 365
 None
 1.31A 4c5lA-5ampA:
undetectable		 4c5lA-5ampA:
20.63
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5c5u PROLYL 4-HYDROXYLASE

(Paramecium
bursaria
Chlorella virus
1) 		PF13640
(2OG-FeII_Oxy_3) 		5 GLY A 184
ASP A 187
ALA A 222
GLY A 223
HIS A 151
 None
None
None
UNX  A 302 ( 3.5A)
None
 0.98A 4c5lA-5c5uA:
undetectable		 4c5lA-5c5uA:
22.70
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5fzp DISPASE
AUTOLYSIS-INDUCING
PROTEIN

(Streptomyces
mobaraensis) 		no annotation 5 GLY A  36
ASP A  18
ALA A  20
GLY A  19
VAL A  15
 None
 1.25A 4c5lA-5fzpA:
undetectable		 4c5lA-5fzpA:
23.74
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5g2v N-ACETYLGLUCOSAMINE-
6-SULFATASE

(Bacteroides
thetaiotaomicron) 		PF00884
(Sulfatase)
PF16347
(DUF4976) 		5 GLY A  87
ASP A 396
ALA A 416
GLY A 415
VAL A 409
 None
 1.08A 4c5lA-5g2vA:
undetectable		 4c5lA-5g2vA:
18.83
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ju6 BETA-GLUCOSIDASE

(Rasamsonia
emersonii) 		PF00933
(Glyco_hydro_3)
PF01915
(Glyco_hydro_3_C)
PF14310
(Fn3-like) 		5 GLY A 504
ASP A 516
ALA A 154
GLY A 155
VAL A 547
 None
 1.31A 4c5lA-5ju6A:
5.8		 4c5lA-5ju6A:
15.70
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5m3q EUKARYOTIC
TRANSLATION
INITIATION FACTOR 6

(Chaetomium
thermophilum) 		PF01912
(eIF-6) 		5 GLY A  69
ALA A  64
GLY A  65
VAL A 135
CYH A 110
 None
 0.97A 4c5lA-5m3qA:
undetectable		 4c5lA-5m3qA:
23.91
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5mkk MULTIDRUG RESISTANCE
ABC TRANSPORTER
ATP-BINDING AND
PERMEASE PROTEIN

(Thermus
thermophilus) 		PF00005
(ABC_tran)
PF00664
(ABC_membrane) 		5 GLY A 448
ALA A 495
GLY A 491
VAL A 450
LYS A 502
 None
 1.28A 4c5lA-5mkkA:
undetectable		 4c5lA-5mkkA:
18.12
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5na4 NADH
DEHYDROGENASE-LIKE
PROTEIN
SAOUHSC_00878

(Staphylococcus
aureus) 		no annotation 5 GLY A 357
ASP A 360
GLY A 361
VAL A 171
HIS A 217
 None
 1.22A 4c5lA-5na4A:
2.8		 4c5lA-5na4A:
16.09
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5o5d GLUCANASE

(Trichoderma
atroviride) 		no annotation 5 GLY A 170
ALA A 165
GLY A 153
MET A 149
VAL A 361
 None
 1.33A 4c5lA-5o5dA:
undetectable		 4c5lA-5o5dA:
13.82
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ttk AMINE OXIDASE

(Pseudomonas
putida) 		PF01593
(Amino_oxidase) 		5 GLY A  65
ALA A 473
GLY A 470
VAL A  58
CYH A  72
 None
 1.33A 4c5lA-5ttkA:
2.7		 4c5lA-5ttkA:
21.11
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5v9x ATP-DEPENDENT DNA
HELICASE

(Mycolicibacterium
smegmatis) 		no annotation 5 GLY A 609
ASP A 661
ALA A 614
GLY A 613
VAL A 420
 None
 1.24A 4c5lA-5v9xA:
undetectable		 4c5lA-5v9xA:
14.53
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5vkt CINNAMYL ALCOHOL
DEHYDROGENASES
(SBCAD4)

(Sorghum bicolor) 		PF00107
(ADH_zinc_N)
PF08240
(ADH_N) 		5 ASP A 125
ALA A 131
GLY A 130
VAL A 118
LYS A 134
 None
 1.31A 4c5lA-5vktA:
5.0		 4c5lA-5vktA:
21.20
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5wou PROTEIN LAP4

(Drosophila
melanogaster) 		no annotation 5 GLY A  17
ASP A  48
ALA A  44
GLY A  45
VAL A  41
 None
 1.24A 4c5lA-5wouA:
undetectable		 4c5lA-5wouA:
15.58
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5wpw 11S GLOBULIN ISOFORM
1

(Cocos nucifera) 		no annotation 5 GLY A 252
ALA A 201
GLY A 202
VAL A 255
CYH A 246
 None
 1.24A 4c5lA-5wpwA:
undetectable		 4c5lA-5wpwA:
19.03
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6f72 MTVAO615

(Thermothelomyces
thermophila) 		no annotation 5 ASP A 135
ALA A 134
GLY A 132
VAL A 128
VAL A 257
 None
 1.41A 4c5lA-6f72A:
undetectable		 4c5lA-6f72A:
15.56