SIMILAR PATTERNS OF AMINO ACIDS FOR 4C49_D_HCYD1384

List of similar pattern of amino acids derived from ASSAM search

Hit pattern: 3D amino acid arrangements similar to known drug binding site

Query pattern: Residues from known binding site for annotated drug that match the hit pattern


(Click link on the last column to view superposed patterns of amino acids in NGL viewer)
(Note that only 3-12 residue patterns can be used for ASSAM searches)
Filter list by:
Hit Macromolecule/
Organism
Pfam Res. Interface HETATM RMSD Dali Z-score Seq. Identity (%) View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1a6c TOBACCO RINGSPOT
VIRUS CAPSID PROTEIN


(Tobacco
ringspot virus)
PF03391
(Nepo_coat)
PF03688
(Nepo_coat_C)
PF03689
(Nepo_coat_N)
5 SER A  45
THR A  59
ILE A  33
PHE A  58
HIS A 163
None
1.38A 4c49D-1a6cA:
undetectable
4c49D-1a6cA:
20.19
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1a7h GAMMAS CRYSTALLIN

(Bos taurus)
PF00030
(Crystall)
5 SER A 166
VAL A 164
GLN A 101
ILE A  92
HIS A 117
None
1.35A 4c49D-1a7hA:
0.0
4c49D-1a7hA:
13.62
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1dgj ALDEHYDE
OXIDOREDUCTASE


(Desulfovibrio
desulfuricans)
PF00111
(Fer2)
PF01315
(Ald_Xan_dh_C)
PF01799
(Fer2_2)
PF02738
(Ald_Xan_dh_C2)
5 SER A 184
ILE A 180
ASN A 800
SER A 179
HIS A  95
None
1.41A 4c49D-1dgjA:
0.0
4c49D-1dgjA:
18.30
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1emy MYOGLOBIN

(Elephas maximus)
PF00042
(Globin)
5 GLN A  64
PHE A  29
ARG A 139
ILE A 107
HIS A  97
CYN  A 155 (-3.8A)
CYN  A 155 ( 4.9A)
None
HEM  A 154 ( 3.9A)
HEM  A 154 (-3.5A)
1.21A 4c49D-1emyA:
undetectable
4c49D-1emyA:
19.14
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1i78 PROTEASE VII

(Escherichia
coli)
PF01278
(Omptin)
5 SER A 137
GLN A 105
THR A 142
SER A  76
PHE A 141
None
None
None
BOG  A 900 (-2.8A)
None
1.31A 4c49D-1i78A:
undetectable
4c49D-1i78A:
20.25
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1itu RENAL DIPEPTIDASE

(Homo sapiens)
PF01244
(Peptidase_M19)
5 THR A 149
ARG A 229
ASN A 231
HIS A 152
TRP A 162
None
None
None
CIL  A 451 (-4.0A)
None
1.31A 4c49D-1ituA:
0.0
4c49D-1ituA:
22.68
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1k38 BETA-LACTAMASE OXA-2

(Salmonella
enterica)
PF00905
(Transpeptidase)
5 SER A 147
GLN A 166
THR A  68
ASN A 143
PHE A  69
None
1.15A 4c49D-1k38A:
0.0
4c49D-1k38A:
18.81
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1kkh MEVALONATE KINASE

(Methanocaldococcus
jannaschii)
PF00288
(GHMP_kinases_N)
PF08544
(GHMP_kinases_C)
5 SER A 129
VAL A 128
THR A  44
ILE A 102
PHE A 100
None
1.40A 4c49D-1kkhA:
0.0
4c49D-1kkhA:
21.14
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1lhu SEX HORMONE-BINDING
GLOBULIN


(Homo sapiens)
PF00054
(Laminin_G_1)
5 SER A 111
VAL A 112
ILE A  78
PHE A  67
HIS A  81
None
None
None
EST  A 301 (-4.0A)
None
1.11A 4c49D-1lhuA:
0.0
4c49D-1lhuA:
18.21
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1naa CELLOBIOSE
DEHYDROGENASE


(Phanerochaete
chrysosporium)
PF00732
(GMC_oxred_N)
PF05199
(GMC_oxred_C)
5 SER A 654
VAL A 653
ILE A 606
PHE A 524
HIS A 526
None
1.31A 4c49D-1naaA:
0.0
4c49D-1naaA:
19.78
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1us2 ENDO-BETA-1,4-XYLANA
SE


(Cellvibrio
japonicus)
PF00331
(Glyco_hydro_10)
PF03426
(CBM_15)
5 VAL A 486
GLN A 466
THR A 496
ILE A 436
PHE A 465
None
XYP  A1609 (-2.7A)
None
None
None
1.45A 4c49D-1us2A:
undetectable
4c49D-1us2A:
21.54
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1vzv VARICELLA-ZOSTER
VIRUS PROTEASE


(Human
alphaherpesvirus
3)
PF00716
(Peptidase_S21)
5 SER A 120
VAL A 119
ILE A  48
ASN A  49
PHE A  73
None
1.44A 4c49D-1vzvA:
undetectable
4c49D-1vzvA:
20.49
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1woq INORGANIC
POLYPHOSPHATE/ATP-GL
UCOMANNOKINASE


(Arthrobacter
sp. KM)
PF00480
(ROK)
5 SER A 184
PHE A 218
ILE A 147
PHE A 206
HIS A 208
None
1.22A 4c49D-1woqA:
undetectable
4c49D-1woqA:
22.34
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1xl8 PEROXISOMAL
CARNITINE
O-OCTANOYLTRANSFERAS
E


(Mus musculus)
PF00755
(Carn_acyltransf)
5 SER A 399
VAL A 576
ILE A 596
PHE A 600
HIS A 601
None
1.23A 4c49D-1xl8A:
undetectable
4c49D-1xl8A:
19.71
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1z5v TUBULIN GAMMA-1
CHAIN


(Homo sapiens)
PF00091
(Tubulin)
PF03953
(Tubulin_C)
5 SER A 140
VAL A 171
GLN A 230
ILE A 228
SER A 226
GSP  A2466 (-3.1A)
None
None
GSP  A2466 (-4.5A)
None
1.30A 4c49D-1z5vA:
undetectable
4c49D-1z5vA:
21.06
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2a9f PUTATIVE MALIC
ENZYME
((S)-MALATE:NAD+
OXIDOREDUCTASE
(DECARBOXYLATING))


(Streptococcus
pyogenes)
PF00390
(malic)
PF03949
(Malic_M)
5 SER A 185
VAL A 189
PHE A 286
ILE A 175
PHE A 262
None
1.13A 4c49D-2a9fA:
undetectable
4c49D-2a9fA:
22.62
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2akz GAMMA ENOLASE

(Homo sapiens)
PF00113
(Enolase_C)
PF03952
(Enolase_N)
5 VAL A 349
GLN A 408
THR A 378
ILE A 133
PHE A 379
None
1.22A 4c49D-2akzA:
undetectable
4c49D-2akzA:
22.03
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2au5 CONSERVED DOMAIN
PROTEIN


(Enterococcus
faecalis)
PF11472
(DUF3206)
5 VAL A  44
GLN A  63
THR A  29
PHE A  28
HIS A  32
None
1.43A 4c49D-2au5A:
undetectable
4c49D-2au5A:
18.38
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2av9 THIOESTERASE

(Pseudomonas
aeruginosa)
PF03061
(4HBT)
5 VAL A  31
GLN A  16
THR A  42
ILE A  82
PHE A  39
None
1.25A 4c49D-2av9A:
undetectable
4c49D-2av9A:
18.37
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2bm3 SCAFFOLDING DOCKERIN
BINDING PROTEIN A


(Ruminiclostridium
thermocellum)
PF00963
(Cohesin)
5 VAL A  72
ILE A  30
ASN A  31
SER A   7
PHE A  36
None
1.41A 4c49D-2bm3A:
undetectable
4c49D-2bm3A:
19.52
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2dvk UPF0130 PROTEIN
APE0816


(Aeropyrum
pernix)
PF02676
(TYW3)
5 SER A 178
VAL A 181
ILE A  34
ASN A  29
HIS A  94
None
1.26A 4c49D-2dvkA:
undetectable
4c49D-2dvkA:
17.55
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2dwz 26S PROTEASE
REGULATORY SUBUNIT
6B


(Rattus
norvegicus)
no annotation 5 SER B 371
THR B 349
PHE B 399
ILE B 378
PHE B 345
None
1.39A 4c49D-2dwzB:
undetectable
4c49D-2dwzB:
12.53
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2e4u METABOTROPIC
GLUTAMATE RECEPTOR 3


(Rattus
norvegicus)
PF01094
(ANF_receptor)
PF07562
(NCD3G)
5 SER A 214
VAL A 213
GLN A 197
SER A 300
PHE A 230
None
1.39A 4c49D-2e4uA:
undetectable
4c49D-2e4uA:
21.80
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2e7t BASIC AGGLUTININ

(Psophocarpus
tetragonolobus)
PF00139
(Lectin_legB)
5 SER A 201
VAL A  57
THR A  70
PHE A  91
ILE A  93
None
1.43A 4c49D-2e7tA:
undetectable
4c49D-2e7tA:
21.58
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2f3n SH3 AND MULTIPLE
ANKYRIN REPEAT
DOMAINS 3


(Rattus
norvegicus)
PF00536
(SAM_1)
5 VAL A  49
ARG A  55
ILE A  58
PHE A  26
HIS A  35
None
1.34A 4c49D-2f3nA:
undetectable
4c49D-2f3nA:
10.91
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2hv2 HYPOTHETICAL PROTEIN

(Enterococcus
faecalis)
PF13527
(Acetyltransf_9)
PF13530
(SCP2_2)
5 VAL A 214
THR A 222
ILE A 243
PHE A 223
HIS A 254
None
1.38A 4c49D-2hv2A:
undetectable
4c49D-2hv2A:
21.18
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2k8q PROTEIN SHQ1

(Saccharomyces
cerevisiae)
no annotation 5 SER A  69
THR A   3
PHE A  42
ILE A  74
ASN A  75
None
1.46A 4c49D-2k8qA:
undetectable
4c49D-2k8qA:
16.67
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2nvu MALTOSE BINDING
PROTEIN/NEDD8-ACTIVA
TING ENZYME E1
CATALYTIC SUBUNIT
CHIMERA
NEDD8-CONJUGATING
ENZYME UBC12


(Homo sapiens)
PF00179
(UQ_con)
PF00899
(ThiF)
PF08825
(E2_bind)
PF13416
(SBP_bac_8)
5 SER B2396
PHE C  80
ILE C 125
ASN C 126
PHE C  60
None
1.39A 4c49D-2nvuB:
undetectable
4c49D-2nvuB:
18.19
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2omo DUF176

(Nitrosomonas
europaea)
PF03992
(ABM)
5 THR A  22
ARG A  37
ILE A  30
ASN A  35
SER A  29
None
1.43A 4c49D-2omoA:
undetectable
4c49D-2omoA:
16.47
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2ucz UBIQUITIN
CONJUGATING ENZYME


(Saccharomyces
cerevisiae)
PF00179
(UQ_con)
5 SER A 122
VAL A 123
THR A  74
ILE A  41
PHE A  73
None
1.47A 4c49D-2uczA:
undetectable
4c49D-2uczA:
18.18
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2v95 CORTICOSTEROID-BINDI
NG GLOBULIN


(Rattus
norvegicus)
PF00079
(Serpin)
7 VAL A  17
GLN A 224
THR A 232
PHE A 234
ARG A 252
ILE A 255
PHE A 357
HCY  A1375 ( 4.8A)
HCY  A1375 (-3.5A)
HCY  A1375 ( 4.2A)
HCY  A1375 (-4.8A)
HCY  A1375 (-4.9A)
None
HCY  A1375 ( 4.1A)
0.69A 4c49D-2v95A:
37.5
4c49D-2v95A:
61.39
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2v95 CORTICOSTEROID-BINDI
NG GLOBULIN


(Rattus
norvegicus)
PF00079
(Serpin)
7 VAL A  17
GLN A 224
THR A 232
PHE A 234
ILE A 255
PHE A 357
TRP A 362
HCY  A1375 ( 4.8A)
HCY  A1375 (-3.5A)
HCY  A1375 ( 4.2A)
HCY  A1375 (-4.8A)
None
HCY  A1375 ( 4.1A)
HCY  A1375 (-3.8A)
0.57A 4c49D-2v95A:
37.5
4c49D-2v95A:
61.39
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2ve3 PUTATIVE CYTOCHROME
P450 120


(Synechocystis
sp. PCC 6803)
PF00067
(p450)
5 SER A 429
THR A  26
PHE A  52
SER A  83
PHE A  29
REA  A1445 ( 4.3A)
None
None
None
REA  A1445 (-4.6A)
1.27A 4c49D-2ve3A:
undetectable
4c49D-2ve3A:
23.71
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2vla RESTRICTION
ENDONUCLEASE R.BPUJI


(Bacillus
pumilus)
PF11564
(BpuJI_N)
5 SER A 156
VAL A 230
PHE A 138
ILE A 141
HIS A 209
None
1.44A 4c49D-2vlaA:
undetectable
4c49D-2vlaA:
20.77
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2vsm HEMAGGLUTININ-NEURAM
INIDASE


(Nipah
henipavirus)
PF00423
(HN)
5 SER A 411
VAL A 367
THR A 308
ILE A 304
PHE A 369
None
1.30A 4c49D-2vsmA:
undetectable
4c49D-2vsmA:
21.32
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2w3j CARBOHYDRATE BINDING
MODULE


(uncultured
bacterium)
PF16990
(CBM_35)
5 VAL A  71
GLN A  93
PHE A  59
ILE A  57
PHE A  83
None
1.19A 4c49D-2w3jA:
undetectable
4c49D-2w3jA:
18.77
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2xf8 D-ERYTHROSE-4-PHOSPH
ATE DEHYDROGENASE


(Escherichia
coli)
PF00044
(Gp_dh_N)
PF02800
(Gp_dh_C)
5 VAL A 172
GLN A 220
PHE A 221
ILE A 158
PHE A 225
None
1.40A 4c49D-2xf8A:
2.4
4c49D-2xf8A:
22.56
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2zxq ENDO-ALPHA-N-ACETYLG
ALACTOSAMINIDASE


(Bifidobacterium
longum)
PF12905
(Glyco_hydro_101)
PF17451
(Glyco_hyd_101C)
5 VAL A1463
PHE A1506
ARG A1493
ILE A1496
ASN A1497
None
1.09A 4c49D-2zxqA:
undetectable
4c49D-2zxqA:
14.33
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3a2b SERINE
PALMITOYLTRANSFERASE


(Sphingobacterium
multivorum)
PF00155
(Aminotran_1_2)
5 SER A 214
VAL A 217
GLN A  35
THR A  58
SER A  51
None
1.43A 4c49D-3a2bA:
undetectable
4c49D-3a2bA:
24.72
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3aqx BETA-1,3-GLUCAN-BIND
ING PROTEIN


(Bombyx mori)
PF15886
(CBM39)
5 GLN A  88
THR A  77
PHE A  75
ILE A  73
PHE A  30
None
1.19A 4c49D-3aqxA:
undetectable
4c49D-3aqxA:
16.36
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3bqw PUTATIVE CAPSID
PROTEIN OF PROPHAGE


(Escherichia
coli)
PF03864
(Phage_cap_E)
5 SER A 249
VAL A 248
THR A 287
PHE A  35
ILE A 208
None
1.43A 4c49D-3bqwA:
undetectable
4c49D-3bqwA:
22.09
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3e1k GALACTOSE/LACTOSE
METABOLISM
REGULATORY PROTEIN
GAL80


(Kluyveromyces
lactis)
PF01408
(GFO_IDH_MocA)
5 VAL A 440
PHE A 280
ASN A 206
PHE A 212
HIS A 214
None
1.36A 4c49D-3e1kA:
undetectable
4c49D-3e1kA:
21.84
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3e1k GALACTOSE/LACTOSE
METABOLISM
REGULATORY PROTEIN
GAL80


(Kluyveromyces
lactis)
PF01408
(GFO_IDH_MocA)
5 VAL A 440
THR A 215
PHE A 280
ASN A 206
HIS A 214
None
1.29A 4c49D-3e1kA:
undetectable
4c49D-3e1kA:
21.84
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3gs3 SYMPLEKIN

(Drosophila
melanogaster)
PF11935
(DUF3453)
5 SER A 147
GLN A 161
ILE A 105
ASN A 106
SER A 109
None
1.22A 4c49D-3gs3A:
undetectable
4c49D-3gs3A:
20.41
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3j4s FTSZ/TUBULIN-RELATED
PROTEIN


(Bacillus
thuringiensis)
PF00091
(Tubulin)
5 VAL A 325
PHE A 291
ILE A 288
PHE A 334
TRP A 365
None
1.40A 4c49D-3j4sA:
undetectable
4c49D-3j4sA:
20.94
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3j6d PROTEIN PRGH

(Salmonella
enterica)
PF09480
(PrgH)
5 ARG A 231
ILE A 232
ASN A 229
PHE A 258
HIS A 249
None
1.33A 4c49D-3j6dA:
undetectable
4c49D-3j6dA:
21.55
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3lma STAGE V SPORULATION
PROTEIN AD (SPOVAD)


(Bacillus
licheniformis)
PF07451
(SpoVAD)
5 SER A  19
VAL A  17
ILE A 117
SER A 113
PHE A 331
None
1.16A 4c49D-3lmaA:
undetectable
4c49D-3lmaA:
23.06
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3lmk METABOTROPIC
GLUTAMATE RECEPTOR 5


(Homo sapiens)
PF01094
(ANF_receptor)
5 SER A 215
VAL A 214
GLN A 198
SER A 304
PHE A 231
None
1.32A 4c49D-3lmkA:
undetectable
4c49D-3lmkA:
21.46
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3lrk ALPHA-GALACTOSIDASE
1


(Saccharomyces
cerevisiae)
PF16499
(Melibiase_2)
5 SER A 347
GLN A 309
ILE A 315
SER A 311
PHE A 464
None
GOL  A7003 (-4.1A)
None
None
None
1.44A 4c49D-3lrkA:
undetectable
4c49D-3lrkA:
22.31
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3pnz PHOSPHOTRIESTERASE
FAMILY PROTEIN


(Listeria
monocytogenes)
PF02126
(PTE)
5 SER A  48
VAL A  52
GLN A 152
ILE A  89
HIS A  22
None
None
None
None
ZN  A 333 ( 3.3A)
1.46A 4c49D-3pnzA:
undetectable
4c49D-3pnzA:
22.28
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3psf TRANSCRIPTION
ELONGATION FACTOR
SPT6


(Saccharomyces
cerevisiae)
PF14635
(HHH_7)
PF14639
(YqgF)
PF14641
(HTH_44)
PF14878
(DLD)
5 SER A 917
THR A 731
ILE A 904
PHE A 729
HIS A 727
None
1.30A 4c49D-3psfA:
undetectable
4c49D-3psfA:
16.47
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3psi TRANSCRIPTION
ELONGATION FACTOR
SPT6


(Saccharomyces
cerevisiae)
PF14635
(HHH_7)
PF14639
(YqgF)
PF14641
(HTH_44)
PF14878
(DLD)
5 SER A 917
THR A 731
ILE A 904
PHE A 729
HIS A 727
None
1.39A 4c49D-3psiA:
undetectable
4c49D-3psiA:
15.14
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3qnb OXACILLINASE

(Escherichia
coli)
PF00905
(Transpeptidase)
5 SER A 147
GLN A 166
THR A  68
ASN A 143
PHE A  69
None
1.21A 4c49D-3qnbA:
undetectable
4c49D-3qnbA:
21.16
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3syb GLYCINE-GLUTAMATE
DIPEPTIDE PORIN OPDP


(Pseudomonas
aeruginosa)
PF03573
(OprD)
5 SER A 203
GLN A 195
THR A 164
ARG A 159
PHE A 167
None
1.29A 4c49D-3sybA:
undetectable
4c49D-3sybA:
21.24
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3t6q CD180 ANTIGEN

(Mus musculus)
PF13855
(LRR_8)
5 SER A 535
GLN A 493
ILE A 486
ASN A 485
PHE A 516
None
1.34A 4c49D-3t6qA:
undetectable
4c49D-3t6qA:
21.20
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3t6q CD180 ANTIGEN

(Mus musculus)
PF13855
(LRR_8)
5 THR A 517
ILE A 486
ASN A 485
PHE A 516
HIS A 514
None
1.36A 4c49D-3t6qA:
undetectable
4c49D-3t6qA:
21.20
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3u1k POLYRIBONUCLEOTIDE
NUCLEOTIDYLTRANSFERA
SE 1, MITOCHONDRIAL


(Homo sapiens)
PF00013
(KH_1)
PF01138
(RNase_PH)
PF03725
(RNase_PH_C)
PF03726
(PNPase)
5 VAL A 313
THR A 287
ASN A 540
PHE A 340
HIS A 288
None
1.42A 4c49D-3u1kA:
undetectable
4c49D-3u1kA:
21.95
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3u44 ATP-DEPENDENT
HELICASE/DEOXYRIBONU
CLEASE SUBUNIT B


(Bacillus
subtilis)
PF12705
(PDDEXK_1)
5 VAL B 544
THR B 512
PHE B 386
ILE B 387
SER B 390
None
1.46A 4c49D-3u44B:
undetectable
4c49D-3u44B:
16.17
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3v9p THYMIDYLATE KINASE

(Burkholderia
thailandensis)
PF02223
(Thymidylate_kin)
5 SER A  96
VAL A  95
GLN A 198
PHE A  24
HIS A  20
None
None
GOL  A 252 ( 4.5A)
None
None
1.37A 4c49D-3v9pA:
undetectable
4c49D-3v9pA:
21.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4a22 FRUCTOSE-BISPHOSPHAT
E ALDOLASE


(Mycobacterium
tuberculosis)
PF01116
(F_bP_aldolase)
5 SER A  31
VAL A  34
THR A  94
PHE A 125
PHE A  52
None
None
NA  A1347 (-3.6A)
None
None
1.44A 4c49D-4a22A:
undetectable
4c49D-4a22A:
20.00
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4c41 CORTICOSTEROID-BINDI
NG GLOBULIN


(Homo sapiens)
PF00079
(Serpin)
6 GLN A 232
THR A 240
PHE A 242
ASN A 264
SER A 267
PHE A 366
None
0.69A 4c49D-4c41A:
56.3
4c49D-4c41A:
99.46
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4c41 CORTICOSTEROID-BINDI
NG GLOBULIN


(Homo sapiens)
PF00079
(Serpin)
7 VAL A  22
GLN A 232
THR A 240
PHE A 242
ILE A 263
ASN A 264
PHE A 366
None
0.71A 4c49D-4c41A:
56.3
4c49D-4c41A:
99.46
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4cdb LISTERIOLYSIN O

(Listeria
monocytogenes)
PF01289
(Thiol_cytolysin)
PF17440
(Thiol_cytolys_C)
5 VAL A 479
PHE A 464
ARG A 507
ILE A 421
SER A 466
None
1.14A 4c49D-4cdbA:
undetectable
4c49D-4cdbA:
21.26
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4dwq TRNA-SPLICING LIGASE
RTCB


(Pyrococcus
horikoshii)
PF01139
(RtcB)
5 SER A 401
GLN A  46
THR A  43
ARG A 350
HIS A  67
None
None
None
None
POP  A 509 (-3.7A)
1.45A 4c49D-4dwqA:
undetectable
4c49D-4dwqA:
20.97
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4edp ABC TRANSPORTER,
SUBSTRATE-BINDING
PROTEIN


(Clostridium
perfringens)
PF13416
(SBP_bac_8)
5 SER A  37
VAL A  36
GLN A 289
THR A 292
ILE A 264
None
None
None
ACT  A 403 (-3.5A)
None
1.28A 4c49D-4edpA:
undetectable
4c49D-4edpA:
24.69
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4fdj N-ACETYLGALACTOSAMIN
E-6-SULFATASE


(Homo sapiens)
PF00884
(Sulfatase)
PF14707
(Sulfatase_C)
5 VAL A 277
PHE A 216
ILE A 217
PHE A 226
HIS A 224
None
1.41A 4c49D-4fdjA:
undetectable
4c49D-4fdjA:
20.70
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4gn2 OXACILLINASE

(Pseudomonas
aeruginosa)
PF00905
(Transpeptidase)
5 SER A 144
GLN A 169
THR A  64
ASN A 140
PHE A  65
None
1.24A 4c49D-4gn2A:
undetectable
4c49D-4gn2A:
20.32
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4hfs UNCHARACTERIZED
PROTEIN YNCM


(Bacillus
subtilis)
PF15493
(YrpD)
5 GLN A 148
THR A 150
ILE A 218
ASN A 242
PHE A  68
None
1.39A 4c49D-4hfsA:
undetectable
4c49D-4hfsA:
21.20
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4kmh SUPPRESSOR OF FUSED
HOMOLOG


(Homo sapiens)
PF05076
(SUFU)
PF12470
(SUFU_C)
5 SER A 377
GLN A 432
ILE A 406
PHE A 408
HIS A 394
None
1.29A 4c49D-4kmhA:
undetectable
4c49D-4kmhA:
21.10
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4l1y SALIVARY NITROPHORIN

(Cimex
lectularius)
no annotation 5 SER A 157
THR A  11
PHE A 278
ILE A 255
PHE A 167
None
1.35A 4c49D-4l1yA:
undetectable
4c49D-4l1yA:
21.26
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4m5p NADPH DEHYDROGENASE

(Scheffersomyces
stipitis)
PF00724
(Oxidored_FMN)
5 SER A 309
VAL A 308
GLN A 200
ILE A 241
HIS A 258
NA  A 505 ( 4.3A)
None
None
None
None
1.45A 4c49D-4m5pA:
undetectable
4c49D-4m5pA:
21.26
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4mb5 CHITINASE 60

(Moritella
marina)
PF00704
(Glyco_hydro_18)
PF16403
(DUF5011)
5 VAL A 270
PHE A 337
ARG A 306
ILE A 338
PHE A 295
None
1.41A 4c49D-4mb5A:
undetectable
4c49D-4mb5A:
21.43
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4mll BETA-LACTAMASE OXA-1

(Escherichia
coli)
PF00905
(Transpeptidase)
5 SER A 147
GLN A 172
THR A  68
ASN A 143
PHE A  69
None
1.26A 4c49D-4mllA:
undetectable
4c49D-4mllA:
23.86
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4pay SIDC, INTERAPTIN

(Legionella
pneumophila)
no annotation 5 SER A 348
GLN A 395
THR A 394
ILE A 399
PHE A 393
None
1.40A 4c49D-4payA:
0.0
4c49D-4payA:
21.46
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4s3l MAJOR PILIN PROTEIN

(Streptococcus
pneumoniae)
no annotation 5 SER A 337
PHE A 305
ILE A 244
ASN A 371
PHE A 261
None
1.45A 4c49D-4s3lA:
undetectable
4c49D-4s3lA:
20.47
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4w5z CHITINASE 60

(Moritella
marina)
PF00704
(Glyco_hydro_18)
5 VAL A 270
PHE A 337
ARG A 306
ILE A 338
PHE A 295
None
1.39A 4c49D-4w5zA:
undetectable
4c49D-4w5zA:
20.95
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4xib E3 UBIQUITIN-PROTEIN
LIGASE MIB1


(Homo sapiens)
PF00569
(ZZ)
PF06701
(MIB_HERC2)
5 VAL A  19
ARG A  20
ILE A 146
PHE A 226
HIS A 230
None
1.39A 4c49D-4xibA:
undetectable
4c49D-4xibA:
21.88
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4xr9 CALS8

(Micromonospora
echinospora)
PF00984
(UDPG_MGDP_dh)
PF03720
(UDPG_MGDP_dh_C)
PF03721
(UDPG_MGDP_dh_N)
5 SER A 394
VAL A 420
PHE A 444
ARG A 419
PHE A 446
None
1.46A 4c49D-4xr9A:
undetectable
4c49D-4xr9A:
21.30
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5b3f PHOSPHORIBULOKINASE/
URIDINE KINASE


(Methanospirillum
hungatei)
PF00485
(PRK)
5 THR A 282
PHE A  41
ARG A  35
ILE A  37
SER A 307
None
1.38A 4c49D-5b3fA:
undetectable
4c49D-5b3fA:
23.74
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5but KTR SYSTEM POTASSIUM
UPTAKE PROTEIN B


(Bacillus
subtilis)
PF02386
(TrkH)
5 SER I 187
PHE I 202
ILE I 198
ASN I 195
PHE I 281
None
1.33A 4c49D-5butI:
undetectable
4c49D-5butI:
23.34
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ctm BETA-LACTAMASE

(Bacillus
pumilus)
PF00905
(Transpeptidase)
5 SER A 181
GLN A 200
THR A 102
ASN A 177
PHE A 103
None
1.27A 4c49D-5ctmA:
undetectable
4c49D-5ctmA:
20.98
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5d79 BERBERINE BRIDGE
ENZYME-LIKE PROTEIN


(Arabidopsis
thaliana)
PF01565
(FAD_binding_4)
PF08031
(BBE)
5 VAL A 104
THR A 517
ILE A  94
SER A 211
PHE A 519
None
1.35A 4c49D-5d79A:
undetectable
4c49D-5d79A:
21.12
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5d9a POLYMERASE BASIC
PROTEIN 2


(Influenza C
virus)
PF00604
(Flu_PB2)
5 SER C 317
VAL C 320
THR C 295
ARG C 267
ILE C 266
None
1.39A 4c49D-5d9aC:
undetectable
4c49D-5d9aC:
20.29
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5dz7 POLYKETIDE
BIOSYNTHESIS PROTEIN
PKSE


(Bacillus
subtilis)
PF00698
(Acyl_transf_1)
5 THR A  54
PHE A 192
ILE A 119
SER A 189
HIS A  53
None
GOL  A 303 (-4.2A)
None
None
None
1.22A 4c49D-5dz7A:
undetectable
4c49D-5dz7A:
23.20
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5e2f BETA-LACTAMASE YBXI

(Bacillus
subtilis)
PF00905
(Transpeptidase)
5 SER A 156
GLN A 175
THR A  77
ASN A 152
PHE A  78
None
1.34A 4c49D-5e2fA:
undetectable
4c49D-5e2fA:
19.53
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5fub PROTEIN ARGININE
METHYLTRANSFERASE 2


(Danio rerio)
PF13649
(Methyltransf_25)
5 VAL A 187
GLN A 105
ILE A 107
ASN A 110
SER A 109
None
1.39A 4c49D-5fubA:
undetectable
4c49D-5fubA:
24.88
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5gs2 REPEBODY

(Escherichia
coli)
PF11921
(DUF3439)
PF12354
(Internalin_N)
PF13855
(LRR_8)
5 VAL B  35
PHE B  18
ILE B  22
ASN B  25
PHE B  13
None
1.44A 4c49D-5gs2B:
undetectable
4c49D-5gs2B:
21.79
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5idu ACYL-COA
DEHYDROGENASE DOMAIN
PROTEIN


(Paraburkholderia
phymatum)
PF00441
(Acyl-CoA_dh_1)
PF02770
(Acyl-CoA_dh_M)
PF02771
(Acyl-CoA_dh_N)
5 SER A 127
VAL A 126
GLN A 233
ILE A 110
PHE A 177
None
1.28A 4c49D-5iduA:
undetectable
4c49D-5iduA:
20.09
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5in2 EXTRACELLULAR
SUPEROXIDE DISMUTASE
[CU-ZN]


(Onchocerca
volvulus)
PF00080
(Sod_Cu)
5 SER A  15
VAL A  35
ILE A  18
PHE A  45
HIS A  48
GOL  A 201 (-3.4A)
None
None
None
CU  A 203 ( 3.2A)
1.41A 4c49D-5in2A:
undetectable
4c49D-5in2A:
18.38
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5jse PHIAB6 TAILSPIKE

(unidentified
phage)
PF12708
(Pectate_lyase_3)
5 VAL A 302
PHE A 310
ILE A 297
PHE A 307
HIS A 262
None
1.32A 4c49D-5jseA:
undetectable
4c49D-5jseA:
19.42
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5k10 ISOCITRATE
DEHYDROGENASE [NADP]
CYTOPLASMIC


(Homo sapiens)
PF00180
(Iso_dh)
5 THR A 325
PHE A 395
ARG A  20
ILE A  21
HIS A 315
None
None
None
None
NDP  A 501 (-4.7A)
1.46A 4c49D-5k10A:
undetectable
4c49D-5k10A:
19.82
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5lxv SCAFFOLDIN C

(Ruminococcus
flavefaciens)
PF00963
(Cohesin)
5 SER A  79
VAL A  78
GLN A  19
ILE A  50
ASN A  82
None
1.41A 4c49D-5lxvA:
undetectable
4c49D-5lxvA:
19.52
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5nug CYTOPLASMIC DYNEIN 1
HEAVY CHAIN 1


(Homo sapiens)
PF03028
(Dynein_heavy)
PF07728
(AAA_5)
PF08393
(DHC_N2)
PF12774
(AAA_6)
PF12775
(AAA_7)
PF12777
(MT)
PF12780
(AAA_8)
PF12781
(AAA_9)
5 VAL A2592
ILE A2666
ASN A2667
PHE A2727
HIS A2725
None
1.27A 4c49D-5nugA:
undetectable
4c49D-5nugA:
5.90
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5o8m YTH
DOMAIN-CONTAINING
PROTEIN MMI1


(Schizosaccharomyces
pombe)
no annotation 5 VAL A 409
ILE A 382
SER A 378
HIS A 426
TRP A 372
None
None
GOL  A 502 (-2.8A)
None
None
1.27A 4c49D-5o8mA:
undetectable
4c49D-5o8mA:
13.45
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5u03 CTP SYNTHASE 1

(Homo sapiens)
PF00117
(GATase)
PF06418
(CTP_synth_N)
5 SER A  22
VAL A  23
GLN A 240
ILE A 178
PHE A 266
None
1.44A 4c49D-5u03A:
undetectable
4c49D-5u03A:
19.59
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5wde KINESIN-LIKE PROTEIN
KIFC3


(Homo sapiens)
PF00225
(Kinesin)
5 SER A 746
VAL A 452
ILE A 479
SER A 489
PHE A 471
None
None
None
UNX  A 920 ( 4.4A)
None
1.34A 4c49D-5wdeA:
undetectable
4c49D-5wdeA:
22.11
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5yww NUCLEOTIDE BINDING
PROTEIN PINC


(Sulfolobus
islandicus)
no annotation 5 SER A 168
VAL A 171
ARG A 172
ILE A 209
SER A 197
None
1.30A 4c49D-5ywwA:
undetectable
4c49D-5ywwA:
12.24
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5znn SORTILIN

(Mus musculus)
no annotation 5 SER A 478
VAL A 486
ILE A 413
SER A 415
HIS A 461
None
1.40A 4c49D-5znnA:
undetectable
4c49D-5znnA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6bqw BACTERIAL ACTIN ALFA

(Bacillus
subtilis)
no annotation 5 SER A 189
VAL A 176
ILE A 215
ASN A 214
PHE A 208
None
1.36A 4c49D-6bqwA:
undetectable
4c49D-6bqwA:
16.67
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6c0f PROTEASOME-INTERACTI
NG PROTEIN CIC1


(Saccharomyces
cerevisiae)
no annotation 5 SER K 105
GLN K 143
THR K 223
ILE K 149
SER K 146
None
1.37A 4c49D-6c0fK:
undetectable
4c49D-6c0fK:
13.98