SIMILAR PATTERNS OF AMINO ACIDS FOR 4C49_C_HCYC1384_1
List of similar pattern of amino acids derived from ASSAM searchHit | Macromolecule/ Organism |
Pfam | Res. | Interface | HETATM | RMSD | Dali Z-score | Seq. Identity (%) | View | Dock | |
---|---|---|---|---|---|---|---|---|---|---|---|
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 1a6c | TOBACCO RINGSPOTVIRUS CAPSID PROTEIN (Tobaccoringspot virus) |
PF03391(Nepo_coat)PF03688(Nepo_coat_C)PF03689(Nepo_coat_N) | 5 | SER A 45THR A 59ILE A 33PHE A 58HIS A 163 | None | 1.32A | 4c49C-1a6cA:0.0 | 4c49C-1a6cA:20.19 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 1hg8 | ENDOPOLYGALACTURONASE (Fusariumverticillioides) |
PF00295(Glyco_hydro_28) | 5 | SER A 159VAL A 132ILE A 141SER A 165PHE A 154 | None | 1.48A | 4c49C-1hg8A:undetectable | 4c49C-1hg8A:23.08 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 1ivz | HYPOTHETICAL PROTEIN1110008I14RIK (Mus musculus) |
PF01390(SEA) | 5 | PHE A 61ARG A 96ILE A 99PHE A 87HIS A 13 | None | 1.42A | 4c49C-1ivzA:0.0 | 4c49C-1ivzA:18.68 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 1k38 | BETA-LACTAMASE OXA-2 (Salmonellaenterica) |
PF00905(Transpeptidase) | 5 | SER A 147GLN A 166THR A 68ASN A 143PHE A 69 | None | 1.18A | 4c49C-1k38A:0.0 | 4c49C-1k38A:18.81 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 1kkh | MEVALONATE KINASE (Methanocaldococcusjannaschii) |
PF00288(GHMP_kinases_N)PF08544(GHMP_kinases_C) | 5 | SER A 129VAL A 128THR A 44ILE A 102PHE A 100 | None | 1.35A | 4c49C-1kkhA:0.0 | 4c49C-1kkhA:21.14 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 1kyo | HEAVY CHAIN (VH) OFFV-FRAGMENT (Mus musculus) |
PF07686(V-set) | 5 | GLN J 78THR J 21ARG J 98ILE J 29PHE J 79 | None | 1.46A | 4c49C-1kyoJ:0.4 | 4c49C-1kyoJ:16.37 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 1led | WEST-CENTRAL AFRICANLEGUME LECTIN IV (Griffoniasimplicifolia) |
PF00139(Lectin_legB) | 5 | SER A 190PHE A 93ILE A 176PHE A 76HIS A 233 | None | 1.41A | 4c49C-1ledA:0.0 | 4c49C-1ledA:20.94 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 1m72 | CASPASE-1 (Spodopterafrugiperda) |
PF00656(Peptidase_C14) | 5 | VAL A 131THR A 159ILE A 115PHE A 158TRP A 155 | None | 1.21A | 4c49C-1m72A:0.0 | 4c49C-1m72A:22.19 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 1mqq | ALPHA-D-GLUCURONIDASE (Geobacillusstearothermophilus) |
PF03648(Glyco_hydro_67N)PF07477(Glyco_hydro_67C)PF07488(Glyco_hydro_67M) | 5 | SER A 444VAL A 443PHE A 320PHE A 365HIS A 527 | NoneNoneGCU A 701 (-3.8A)NoneGOL A 753 (-4.0A) | 1.45A | 4c49C-1mqqA:undetectable | 4c49C-1mqqA:19.51 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 1naa | CELLOBIOSEDEHYDROGENASE (Phanerochaetechrysosporium) |
PF00732(GMC_oxred_N)PF05199(GMC_oxred_C) | 5 | SER A 654VAL A 653ILE A 606PHE A 524HIS A 526 | None | 1.25A | 4c49C-1naaA:undetectable | 4c49C-1naaA:19.78 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 1nsa | PROCARBOXYPEPTIDASEB (Sus scrofa) |
PF00246(Peptidase_M14)PF02244(Propep_M14) | 5 | VAL A 64PHE A 37ARG A 33ILE A 35HIS A 27 | None | 1.46A | 4c49C-1nsaA:undetectable | 4c49C-1nsaA:21.56 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 1oq1 | PROTEIN YESU (Bacillussubtilis) |
PF09224(DUF1961) | 5 | SER A 17VAL A 19GLN A 201ILE A 30PHE A 50 | None | 1.44A | 4c49C-1oq1A:undetectable | 4c49C-1oq1A:19.31 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 1r8w | GLYCEROL DEHYDRATASE (Clostridiumbutyricum) |
PF01228(Gly_radical)PF02901(PFL-like) | 5 | VAL A 563GLN A 494ILE A 461SER A 463PHE A 487 | None | 1.46A | 4c49C-1r8wA:undetectable | 4c49C-1r8wA:18.47 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 1w61 | B-CELL MITOGEN (Trypanosomacruzi) |
PF05544(Pro_racemase) | 5 | VAL A 271GLN A 195ARG A 248ILE A 251ASN A 252 | None | 1.37A | 4c49C-1w61A:undetectable | 4c49C-1w61A:23.67 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 1woq | INORGANICPOLYPHOSPHATE/ATP-GLUCOMANNOKINASE (Arthrobactersp. KM) |
PF00480(ROK) | 5 | SER A 184PHE A 218ILE A 147PHE A 206HIS A 208 | None | 1.17A | 4c49C-1woqA:undetectable | 4c49C-1woqA:22.34 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 1z5v | TUBULIN GAMMA-1CHAIN (Homo sapiens) |
PF00091(Tubulin)PF03953(Tubulin_C) | 5 | SER A 140VAL A 171GLN A 230ILE A 228SER A 226 | GSP A2466 (-3.1A)NoneNoneGSP A2466 (-4.5A)None | 1.23A | 4c49C-1z5vA:undetectable | 4c49C-1z5vA:21.06 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 2a9f | PUTATIVE MALICENZYME((S)-MALATE:NAD+OXIDOREDUCTASE(DECARBOXYLATING)) (Streptococcuspyogenes) |
PF00390(malic)PF03949(Malic_M) | 5 | SER A 185VAL A 189PHE A 286ILE A 175PHE A 262 | None | 1.05A | 4c49C-2a9fA:undetectable | 4c49C-2a9fA:22.62 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 2akz | GAMMA ENOLASE (Homo sapiens) |
PF00113(Enolase_C)PF03952(Enolase_N) | 5 | VAL A 349GLN A 408THR A 378ILE A 133PHE A 379 | None | 1.19A | 4c49C-2akzA:undetectable | 4c49C-2akzA:22.03 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 2av9 | THIOESTERASE (Pseudomonasaeruginosa) |
PF03061(4HBT) | 5 | VAL A 31GLN A 16THR A 42ILE A 82PHE A 39 | None | 1.28A | 4c49C-2av9A:undetectable | 4c49C-2av9A:18.37 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 2bo9 | HUMAN LATEXIN (Homo sapiens) |
PF06907(Latexin) | 5 | VAL B 58PHE B 89ILE B 21ASN B 22PHE B 91 | None | 1.35A | 4c49C-2bo9B:undetectable | 4c49C-2bo9B:18.57 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 2c5q | RRAA-LIKE PROTEINYER010C (Saccharomycescerevisiae) |
PF03737(RraA-like) | 5 | VAL A 116GLN A 167THR A 161ILE A 169PHE A 118 | NoneEDO A1234 (-3.6A)NoneCME A 170 ( 3.9A)None | 1.41A | 4c49C-2c5qA:undetectable | 4c49C-2c5qA:22.19 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 2dwz | 26S PROTEASEREGULATORY SUBUNIT6B (Rattusnorvegicus) |
no annotation | 5 | SER B 371THR B 349PHE B 399ILE B 378PHE B 345 | None | 1.45A | 4c49C-2dwzB:undetectable | 4c49C-2dwzB:12.53 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 2f3n | SH3 AND MULTIPLEANKYRIN REPEATDOMAINS 3 (Rattusnorvegicus) |
PF00536(SAM_1) | 5 | VAL A 49ARG A 55ILE A 58PHE A 26HIS A 35 | None | 1.41A | 4c49C-2f3nA:undetectable | 4c49C-2f3nA:10.91 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 2fv5 | ADAM 17 (Homo sapiens) |
PF13688(Reprolysin_5) | 5 | VAL A 364THR A 404ILE A 458SER A 454HIS A 405 | NoneNoneNoneNone ZN A 3 ( 3.2A) | 1.26A | 4c49C-2fv5A:undetectable | 4c49C-2fv5A:22.98 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 2hv2 | HYPOTHETICAL PROTEIN (Enterococcusfaecalis) |
PF13527(Acetyltransf_9)PF13530(SCP2_2) | 5 | VAL A 214THR A 222ILE A 243PHE A 223HIS A 254 | None | 1.41A | 4c49C-2hv2A:undetectable | 4c49C-2hv2A:21.18 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 2nn3 | CASPASE-1 (Spodopterafrugiperda) |
PF00656(Peptidase_C14) | 5 | VAL C 131THR C 159ILE C 115PHE C 158TRP C 155 | None | 1.29A | 4c49C-2nn3C:undetectable | 4c49C-2nn3C:20.91 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 2nvu | MALTOSE BINDINGPROTEIN/NEDD8-ACTIVATING ENZYME E1CATALYTIC SUBUNITCHIMERANEDD8-CONJUGATINGENZYME UBC12 (Homo sapiens) |
PF00179(UQ_con)PF00899(ThiF)PF08825(E2_bind)PF13416(SBP_bac_8) | 5 | SER B2396PHE C 80ILE C 125ASN C 126PHE C 60 | None | 1.33A | 4c49C-2nvuB:undetectable | 4c49C-2nvuB:18.19 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 2omo | DUF176 (Nitrosomonaseuropaea) |
PF03992(ABM) | 5 | THR A 22ARG A 37ILE A 30ASN A 35SER A 29 | None | 1.43A | 4c49C-2omoA:undetectable | 4c49C-2omoA:16.47 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 2pg6 | CYTOCHROME P450 2A6 (Homo sapiens) |
PF00067(p450) | 5 | SER A 175THR A 212PHE A 107ILE A 300PHE A 209 | None | 1.47A | 4c49C-2pg6A:undetectable | 4c49C-2pg6A:21.49 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 2r0b | SERINE/THREONINE/TYROSINE-INTERACTINGPROTEIN (Homo sapiens) |
PF00782(DSPc) | 5 | THR A 102PHE A 130ILE A 95ASN A 94PHE A 99 | None | 1.24A | 4c49C-2r0bA:undetectable | 4c49C-2r0bA:18.28 | ||
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target. | 2v95 | CORTICOSTEROID-BINDING GLOBULIN (Rattusnorvegicus) |
PF00079(Serpin) | 8 | VAL A 17GLN A 224THR A 232PHE A 234ARG A 252ILE A 255PHE A 357TRP A 362 | HCY A1375 ( 4.8A)HCY A1375 (-3.5A)HCY A1375 ( 4.2A)HCY A1375 (-4.8A)HCY A1375 (-4.9A)NoneHCY A1375 ( 4.1A)HCY A1375 (-3.8A) | 0.65A | 4c49C-2v95A:39.2 | 4c49C-2v95A:61.39 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 2ve3 | PUTATIVE CYTOCHROMEP450 120 (Synechocystissp. PCC 6803) |
PF00067(p450) | 5 | SER A 429THR A 26PHE A 52SER A 83PHE A 29 | REA A1445 ( 4.3A)NoneNoneNoneREA A1445 (-4.6A) | 1.35A | 4c49C-2ve3A:undetectable | 4c49C-2ve3A:23.71 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 2vsm | HEMAGGLUTININ-NEURAMINIDASE (Nipahhenipavirus) |
PF00423(HN) | 5 | SER A 411VAL A 367THR A 308ILE A 304PHE A 369 | None | 1.20A | 4c49C-2vsmA:undetectable | 4c49C-2vsmA:21.32 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 2w3j | CARBOHYDRATE BINDINGMODULE (unculturedbacterium) |
PF16990(CBM_35) | 5 | VAL A 71GLN A 93PHE A 59ILE A 57PHE A 83 | None | 1.26A | 4c49C-2w3jA:undetectable | 4c49C-2w3jA:18.77 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 2x7j | 2-SUCCINYL-5-ENOLPYRUVYL-6-HYDROXY-3-CYCLOHEXENE-1-CARBOXYLATESYNTHASE (Bacillussubtilis) |
PF02775(TPP_enzyme_C)PF02776(TPP_enzyme_N)PF16582(TPP_enzyme_M_2) | 5 | VAL A 394ILE A 424ASN A 256SER A 255PHE A 415 | None | 1.39A | 4c49C-2x7jA:undetectable | 4c49C-2x7jA:22.41 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 2xax | RIBONUCLEOSIDE-DIPHOSPHATE REDUCTASE 1SUBUNIT ALPHA (Escherichiacoli) |
PF00317(Ribonuc_red_lgN)PF02867(Ribonuc_red_lgC)PF03477(ATP-cone) | 5 | PHE A 285ILE A 237ASN A 238SER A 241PHE A 281 | None | 1.38A | 4c49C-2xaxA:undetectable | 4c49C-2xaxA:19.73 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 2xax | RIBONUCLEOSIDE-DIPHOSPHATE REDUCTASE 1SUBUNIT ALPHA (Escherichiacoli) |
PF00317(Ribonuc_red_lgN)PF02867(Ribonuc_red_lgC)PF03477(ATP-cone) | 5 | THR A 276PHE A 281ILE A 237ASN A 238PHE A 274 | None | 1.28A | 4c49C-2xaxA:undetectable | 4c49C-2xaxA:19.73 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 2xf8 | D-ERYTHROSE-4-PHOSPHATE DEHYDROGENASE (Escherichiacoli) |
PF00044(Gp_dh_N)PF02800(Gp_dh_C) | 5 | VAL A 172GLN A 220PHE A 221ILE A 158PHE A 225 | None | 1.41A | 4c49C-2xf8A:undetectable | 4c49C-2xf8A:22.56 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 2zxq | ENDO-ALPHA-N-ACETYLGALACTOSAMINIDASE (Bifidobacteriumlongum) |
PF12905(Glyco_hydro_101)PF17451(Glyco_hyd_101C) | 5 | VAL A1463PHE A1506ARG A1493ILE A1496ASN A1497 | None | 1.08A | 4c49C-2zxqA:undetectable | 4c49C-2zxqA:14.33 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3afl | OLIGO ALGINATE LYASE (Agrobacteriumfabrum) |
PF07940(Hepar_II_III)PF16332(DUF4962) | 5 | SER A 650GLN A 656THR A 721ILE A 578ASN A 623 | None | 1.35A | 4c49C-3aflA:undetectable | 4c49C-3aflA:19.74 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3e1k | GALACTOSE/LACTOSEMETABOLISMREGULATORY PROTEINGAL80 (Kluyveromyceslactis) |
PF01408(GFO_IDH_MocA) | 5 | VAL A 440PHE A 280ASN A 206PHE A 212HIS A 214 | None | 1.38A | 4c49C-3e1kA:undetectable | 4c49C-3e1kA:21.84 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3e1k | GALACTOSE/LACTOSEMETABOLISMREGULATORY PROTEINGAL80 (Kluyveromyceslactis) |
PF01408(GFO_IDH_MocA) | 5 | VAL A 440THR A 215PHE A 280ASN A 206HIS A 214 | None | 1.33A | 4c49C-3e1kA:undetectable | 4c49C-3e1kA:21.84 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3eqn | GLUCAN1,3-BETA-GLUCOSIDASE (Phanerochaetechrysosporium) |
PF12708(Pectate_lyase_3) | 5 | SER A 152VAL A 153GLN A 196THR A 168HIS A 171 | None | 1.44A | 4c49C-3eqnA:undetectable | 4c49C-3eqnA:18.87 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3l1c | KINESIN-14 NCD (Drosophilamelanogaster) |
PF00225(Kinesin) | 5 | SER A 416VAL A 415ILE A 411SER A 406PHE A 644 | None | 1.47A | 4c49C-3l1cA:undetectable | 4c49C-3l1cA:23.22 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3llr | DNA(CYTOSINE-5)-METHYLTRANSFERASE 3A (Homo sapiens) |
PF00855(PWWP) | 5 | SER A 103PHE A 80ILE A 133ASN A 129PHE A 76 | None | 1.44A | 4c49C-3llrA:undetectable | 4c49C-3llrA:18.43 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3psf | TRANSCRIPTIONELONGATION FACTORSPT6 (Saccharomycescerevisiae) |
PF14635(HHH_7)PF14639(YqgF)PF14641(HTH_44)PF14878(DLD) | 5 | SER A 917THR A 731ILE A 904PHE A 729HIS A 727 | None | 1.24A | 4c49C-3psfA:undetectable | 4c49C-3psfA:16.47 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3psi | TRANSCRIPTIONELONGATION FACTORSPT6 (Saccharomycescerevisiae) |
PF14635(HHH_7)PF14639(YqgF)PF14641(HTH_44)PF14878(DLD) | 5 | SER A 917THR A 731ILE A 904PHE A 729HIS A 727 | None | 1.31A | 4c49C-3psiA:undetectable | 4c49C-3psiA:15.14 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3qnb | OXACILLINASE (Escherichiacoli) |
PF00905(Transpeptidase) | 5 | SER A 147GLN A 166THR A 68ASN A 143PHE A 69 | None | 1.27A | 4c49C-3qnbA:undetectable | 4c49C-3qnbA:21.16 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3sx2 | PUTATIVE3-KETOACYL-(ACYL-CARRIER-PROTEIN)REDUCTASE (Mycobacteriumavium) |
PF13561(adh_short_C2) | 5 | SER A 49VAL A 50GLN A 23THR A 208ASN A 127 | NoneNoneNAD A 300 (-3.3A)NAD A 300 (-2.8A)NAD A 300 ( 4.6A) | 1.44A | 4c49C-3sx2A:undetectable | 4c49C-3sx2A:21.59 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3t6q | CD180 ANTIGEN (Mus musculus) |
PF13855(LRR_8) | 5 | SER A 535GLN A 493ILE A 486ASN A 485PHE A 516 | None | 1.29A | 4c49C-3t6qA:undetectable | 4c49C-3t6qA:21.20 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3ti2 | 3-PHOSPHOSHIKIMATE1-CARBOXYVINYLTRANSFERASE (Vibrio cholerae) |
PF00275(EPSP_synthase) | 5 | SER A 23VAL A 24THR A 39ARG A 27PHE A 238 | NoneNoneNone CL A 1 ( 3.0A)None | 1.37A | 4c49C-3ti2A:undetectable | 4c49C-3ti2A:23.95 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3u1k | POLYRIBONUCLEOTIDENUCLEOTIDYLTRANSFERASE 1, MITOCHONDRIAL (Homo sapiens) |
PF00013(KH_1)PF01138(RNase_PH)PF03725(RNase_PH_C)PF03726(PNPase) | 5 | VAL A 313THR A 287ASN A 540PHE A 340HIS A 288 | None | 1.42A | 4c49C-3u1kA:undetectable | 4c49C-3u1kA:21.95 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3vvw | CALCIUM-BINDING ANDCOILED-COILDOMAIN-CONTAININGPROTEIN 2 (Homo sapiens) |
PF07888(CALCOCO1) | 5 | VAL A 23PHE A 107ILE A 56PHE A 25HIS A 41 | None | 1.20A | 4c49C-3vvwA:undetectable | 4c49C-3vvwA:14.91 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3zgx | CHROMOSOME PARTITIONPROTEIN SMC (Bacillussubtilis) |
PF02463(SMC_N) | 5 | VAL A1072THR A1036ARG A 157SER A1104PHE A1037 | None | 1.48A | 4c49C-3zgxA:undetectable | 4c49C-3zgxA:23.85 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3zpm | LATHERIN (Equus caballus) |
PF01273(LBP_BPI_CETP) | 5 | SER A 93VAL A 94GLN A 43THR A 39ILE A 159 | None | 1.36A | 4c49C-3zpmA:undetectable | 4c49C-3zpmA:22.25 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4a22 | FRUCTOSE-BISPHOSPHATE ALDOLASE (Mycobacteriumtuberculosis) |
PF01116(F_bP_aldolase) | 5 | SER A 31VAL A 34THR A 94PHE A 125PHE A 52 | NoneNone NA A1347 (-3.6A)NoneNone | 1.41A | 4c49C-4a22A:undetectable | 4c49C-4a22A:20.00 | ||
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target. | 4c41 | CORTICOSTEROID-BINDING GLOBULIN (Homo sapiens) |
PF00079(Serpin) | 5 | GLN A 232THR A 240PHE A 242ASN A 264SER A 267 | None | 0.84A | 4c49C-4c41A:58.2 | 4c49C-4c41A:99.46 | ||
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target. | 4c41 | CORTICOSTEROID-BINDING GLOBULIN (Homo sapiens) |
PF00079(Serpin) | 5 | THR A 240PHE A 242ASN A 264SER A 267HIS A 368 | None | 1.03A | 4c49C-4c41A:58.2 | 4c49C-4c41A:99.46 | ||
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target. | 4c41 | CORTICOSTEROID-BINDING GLOBULIN (Homo sapiens) |
PF00079(Serpin) | 7 | VAL A 22GLN A 232THR A 240PHE A 242ILE A 263ASN A 264PHE A 366 | None | 0.67A | 4c49C-4c41A:58.2 | 4c49C-4c41A:99.46 | ||
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target. | 4c41 | CORTICOSTEROID-BINDING GLOBULIN (Homo sapiens) |
PF00079(Serpin) | 6 | VAL A 22THR A 240PHE A 242ASN A 264PHE A 366HIS A 368 | None | 0.82A | 4c49C-4c41A:58.2 | 4c49C-4c41A:99.46 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4dji | PROBABLEGLUTAMATE/GAMMA-AMINOBUTYRATE ANTIPORTER (Escherichiacoli) |
PF13520(AA_permease_2) | 5 | VAL A 110GLN A 345THR A 349PHE A 103ILE A 305 | None | 1.29A | 4c49C-4djiA:undetectable | 4c49C-4djiA:24.71 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4ej0 | ADP-L-GLYCERO-D-MANNO-HEPTOSE-6-EPIMERASE (Burkholderiathailandensis) |
PF01370(Epimerase) | 5 | SER A 97VAL A 100PHE A 66ILE A 4PHE A 61 | None | 1.37A | 4c49C-4ej0A:undetectable | 4c49C-4ej0A:22.60 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4gn2 | OXACILLINASE (Pseudomonasaeruginosa) |
PF00905(Transpeptidase) | 5 | SER A 144GLN A 169THR A 64ASN A 140PHE A 65 | None | 1.29A | 4c49C-4gn2A:undetectable | 4c49C-4gn2A:20.32 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4i95 | PUTATIVEUNCHARACTERIZEDPROTEIN (Bacteroideseggerthii) |
PF14869(DUF4488) | 5 | GLN A 38PHE A 59ARG A 74ILE A 73HIS A 41 | None | 1.38A | 4c49C-4i95A:undetectable | 4c49C-4i95A:17.20 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4ilr | CRISPR-ASSOCIATEDENDORIBONUCLEASECAS6 2 (Sulfolobussolfataricus) |
PF10040(CRISPR_Cas6) | 5 | SER A 149ILE A 203ASN A 206SER A 205PHE A 199 | None | 1.31A | 4c49C-4ilrA:undetectable | 4c49C-4ilrA:21.76 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4l1y | SALIVARY NITROPHORIN (Cimexlectularius) |
no annotation | 5 | SER A 157THR A 11PHE A 278ILE A 255PHE A 167 | None | 1.37A | 4c49C-4l1yA:undetectable | 4c49C-4l1yA:21.26 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4mll | BETA-LACTAMASE OXA-1 (Escherichiacoli) |
PF00905(Transpeptidase) | 5 | SER A 147GLN A 172THR A 68ASN A 143PHE A 69 | None | 1.31A | 4c49C-4mllA:undetectable | 4c49C-4mllA:23.86 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4mn8 | LRR RECEPTOR-LIKESERINE/THREONINE-PROTEIN KINASE FLS2 (Arabidopsisthaliana) |
PF00560(LRR_1)PF08263(LRRNT_2)PF13516(LRR_6)PF13855(LRR_8) | 5 | THR A 603ILE A 606ASN A 609SER A 607PHE A 604 | None | 1.40A | 4c49C-4mn8A:undetectable | 4c49C-4mn8A:19.49 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4mna | LRR RECEPTOR-LIKESERINE/THREONINE-PROTEIN KINASE FLS2 (Arabidopsisthaliana) |
PF00560(LRR_1)PF08263(LRRNT_2)PF13516(LRR_6)PF13855(LRR_8) | 5 | THR A 603ILE A 606ASN A 609SER A 607PHE A 604 | NoneNoneNoneNAG A 902 (-2.9A)None | 1.46A | 4c49C-4mnaA:undetectable | 4c49C-4mnaA:20.57 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4mt1 | DRUG EFFLUX PROTEIN (Neisseriagonorrhoeae) |
PF00873(ACR_tran) | 5 | SER A1025VAL A1026PHE A 517ILE A 983PHE A 979 | None | 1.41A | 4c49C-4mt1A:undetectable | 4c49C-4mt1A:16.70 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4pfw | ABC TRANSPORTERSUBSTRATE-BINDINGPROTEIN (Thermotogamaritima) |
PF00496(SBP_bac_5) | 5 | VAL A 213ARG A 92ILE A 95HIS A 98TRP A 208 | None | 1.47A | 4c49C-4pfwA:undetectable | 4c49C-4pfwA:21.22 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4s3l | MAJOR PILIN PROTEIN (Streptococcuspneumoniae) |
no annotation | 5 | SER A 337PHE A 305ILE A 244ASN A 371PHE A 261 | None | 1.35A | 4c49C-4s3lA:undetectable | 4c49C-4s3lA:20.47 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4zhj | MG-CHELATASE SUBUNITCHLH (Synechocystissp. PCC 6803) |
PF02514(CobN-Mg_chel)PF11965(DUF3479) | 5 | SER A1101THR A 470ILE A 663SER A 659HIS A1174 | None | 1.29A | 4c49C-4zhjA:undetectable | 4c49C-4zhjA:14.75 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4zke | SUPERKILLER PROTEIN7 (Saccharomycescerevisiae) |
PF00009(GTP_EFTU) | 5 | GLN A 568THR A 681PHE A 715ILE A 710HIS A 678 | GLN A 568 ( 0.6A)THR A 681 ( 0.8A)PHE A 715 ( 1.3A)ILE A 710 ( 0.7A)HIS A 678 ( 1.0A) | 1.06A | 4c49C-4zkeA:undetectable | 4c49C-4zkeA:23.27 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 5amq | RNA POLYMERASE L (Californiaencephalitisorthobunyavirus) |
PF04196(Bunya_RdRp)PF15518(L_protein_N) | 5 | SER A 330PHE A 545ILE A 543SER A 560HIS A 578 | None | 1.37A | 4c49C-5amqA:undetectable | 4c49C-5amqA:10.66 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 5bu6 | BPSB (PGAB),POLY-BETA-1,6-N-ACETYL-D-GLUCOSAMINEN-DEACETYLASE (Bordetellabronchiseptica) |
PF01522(Polysacc_deac_1) | 5 | SER A 47THR A 42ARG A 290ILE A 288PHE A 43 | NoneNoneSCN A 404 (-4.1A)NoneNone | 1.22A | 4c49C-5bu6A:undetectable | 4c49C-5bu6A:21.35 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 5but | KTR SYSTEM POTASSIUMUPTAKE PROTEIN B (Bacillussubtilis) |
PF02386(TrkH) | 5 | SER I 187PHE I 202ILE I 198ASN I 195PHE I 281 | None | 1.33A | 4c49C-5butI:undetectable | 4c49C-5butI:23.34 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 5ctm | BETA-LACTAMASE (Bacilluspumilus) |
PF00905(Transpeptidase) | 5 | SER A 181GLN A 200THR A 102ASN A 177PHE A 103 | None | 1.33A | 4c49C-5ctmA:undetectable | 4c49C-5ctmA:20.98 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 5d2n | C25 BETA (Homo sapiens) |
no annotation | 5 | SER F 7GLN F 54THR F 47PHE F 49ARG F 22 | None | 1.01A | 4c49C-5d2nF:undetectable | 4c49C-5d2nF:23.38 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 5d5t | UNCHARACTERIZEDPROTEIN MJ0489 (Methanocaldococcusjannaschii) |
PF06690(DUF1188) | 5 | SER A 263VAL A 265THR A 159PHE A 136ILE A 137 | None | 1.40A | 4c49C-5d5tA:undetectable | 4c49C-5d5tA:20.51 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 5d9a | POLYMERASE BASICPROTEIN 2 (Influenza Cvirus) |
PF00604(Flu_PB2) | 5 | SER C 317VAL C 320THR C 295ARG C 267ILE C 266 | None | 1.37A | 4c49C-5d9aC:undetectable | 4c49C-5d9aC:20.29 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 5dz7 | POLYKETIDEBIOSYNTHESIS PROTEINPKSE (Bacillussubtilis) |
PF00698(Acyl_transf_1) | 5 | THR A 54PHE A 192ILE A 119SER A 189HIS A 53 | NoneGOL A 303 (-4.2A)NoneNoneNone | 1.26A | 4c49C-5dz7A:undetectable | 4c49C-5dz7A:23.20 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 5e2f | BETA-LACTAMASE YBXI (Bacillussubtilis) |
PF00905(Transpeptidase) | 5 | SER A 156GLN A 175THR A 77ASN A 152PHE A 78 | None | 1.38A | 4c49C-5e2fA:undetectable | 4c49C-5e2fA:19.53 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 5erd | DESMOGLEIN-2 (Homo sapiens) |
PF00028(Cadherin) | 5 | SER A 148GLN A 112PHE A 115ILE A 132PHE A 110 | None | 1.32A | 4c49C-5erdA:undetectable | 4c49C-5erdA:21.07 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 5ern | FUSICOCCADIENESYNTHASE (Diaportheamygdali) |
PF00348(polyprenyl_synt) | 5 | VAL A 77THR A 208PHE A 55ILE A 56HIS A 205 | None | 1.23A | 4c49C-5ernA:undetectable | 4c49C-5ernA:22.06 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 5fub | PROTEIN ARGININEMETHYLTRANSFERASE 2 (Danio rerio) |
PF13649(Methyltransf_25) | 5 | VAL A 187GLN A 105ILE A 107ASN A 110SER A 109 | None | 1.31A | 4c49C-5fubA:undetectable | 4c49C-5fubA:24.88 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 5hx6 | RECEPTOR-INTERACTINGSERINE/THREONINE-PROTEIN KINASE 1 (Homo sapiens) |
PF07714(Pkinase_Tyr) | 5 | SER A 73PHE A 278ARG A 74ILE A 123HIS A 136 | NoneNoneNoneNone65U A 301 (-3.3A) | 1.46A | 4c49C-5hx6A:undetectable | 4c49C-5hx6A:21.20 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 5i6c | URIC ACID-XANTHINEPERMEASE (Aspergillusnidulans) |
PF00860(Xan_ur_permease) | 5 | SER A 154VAL A 153GLN A 112ILE A 101SER A 103 | XAN A1001 (-3.5A)NoneNoneNoneNone | 1.38A | 4c49C-5i6cA:undetectable | 4c49C-5i6cA:20.31 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 5idu | ACYL-COADEHYDROGENASE DOMAINPROTEIN (Paraburkholderiaphymatum) |
PF00441(Acyl-CoA_dh_1)PF02770(Acyl-CoA_dh_M)PF02771(Acyl-CoA_dh_N) | 5 | SER A 127VAL A 126GLN A 233ILE A 110PHE A 177 | None | 1.22A | 4c49C-5iduA:undetectable | 4c49C-5iduA:20.09 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 5in2 | EXTRACELLULARSUPEROXIDE DISMUTASE[CU-ZN] (Onchocercavolvulus) |
PF00080(Sod_Cu) | 5 | SER A 15VAL A 35ILE A 18PHE A 45HIS A 48 | GOL A 201 (-3.4A)NoneNoneNone CU A 203 ( 3.2A) | 1.46A | 4c49C-5in2A:undetectable | 4c49C-5in2A:18.38 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 5j5j | DESMOCOLLIN-2,DESMOGLEIN-2 (Homo sapiens) |
PF00028(Cadherin) | 5 | SER A 146GLN A 110PHE A 113ILE A 130PHE A 108 | None | 1.35A | 4c49C-5j5jA:undetectable | 4c49C-5j5jA:19.89 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 5j72 | PUTATIVEN-ACETYLMURAMOYL-L-ALANINEAMIDASE,AUTOLYSINCWP6 (Clostridioidesdifficile) |
PF01520(Amidase_3)PF04122(CW_binding_2) | 5 | SER A 444THR A 403ILE A 436ASN A 437SER A 434 | None | 1.37A | 4c49C-5j72A:undetectable | 4c49C-5j72A:20.97 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 5j72 | PUTATIVEN-ACETYLMURAMOYL-L-ALANINEAMIDASE,AUTOLYSINCWP6 (Clostridioidesdifficile) |
PF01520(Amidase_3)PF04122(CW_binding_2) | 5 | VAL A 424THR A 403ILE A 436ASN A 437SER A 434 | None | 1.20A | 4c49C-5j72A:undetectable | 4c49C-5j72A:20.97 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 5oar | BETA-HEXOSAMINIDASE (Aspergillusoryzae) |
no annotation | 5 | SER A 50THR B 154ILE B 141PHE B 153HIS B 151 | None | 1.44A | 4c49C-5oarA:undetectable | 4c49C-5oarA:11.88 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 5t9p | RIBOSOME BIOGENESISPROTEIN 15 (Saccharomycescerevisiae) |
no annotation | 5 | SER B 96VAL B 95GLN B 113PHE B 114PHE B 111 | CL B 206 ( 4.6A)NoneNoneNoneNone | 1.36A | 4c49C-5t9pB:undetectable | 4c49C-5t9pB:19.09 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 5u03 | CTP SYNTHASE 1 (Homo sapiens) |
PF00117(GATase)PF06418(CTP_synth_N) | 5 | SER A 22VAL A 23GLN A 240ILE A 178PHE A 266 | None | 1.44A | 4c49C-5u03A:undetectable | 4c49C-5u03A:19.59 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 5wde | KINESIN-LIKE PROTEINKIFC3 (Homo sapiens) |
PF00225(Kinesin) | 5 | SER A 746VAL A 452ILE A 479SER A 489PHE A 471 | NoneNoneNoneUNX A 920 ( 4.4A)None | 1.38A | 4c49C-5wdeA:undetectable | 4c49C-5wdeA:22.11 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 5yww | NUCLEOTIDE BINDINGPROTEIN PINC (Sulfolobusislandicus) |
no annotation | 5 | SER A 168VAL A 171ARG A 172ILE A 209SER A 197 | None | 1.37A | 4c49C-5ywwA:undetectable | 4c49C-5ywwA:12.24 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 5znn | SORTILIN (Mus musculus) |
no annotation | 5 | SER A 478VAL A 486ILE A 413SER A 415HIS A 461 | None | 1.39A | 4c49C-5znnA:undetectable | 4c49C-5znnA:undetectable | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 6bqw | BACTERIAL ACTIN ALFA (Bacillussubtilis) |
no annotation | 5 | SER A 189VAL A 176ILE A 215ASN A 214PHE A 208 | None | 1.27A | 4c49C-6bqwA:undetectable | 4c49C-6bqwA:16.67 |