SIMILAR PATTERNS OF AMINO ACIDS FOR 4C49_C_HCYC1384_1

List of similar pattern of amino acids derived from ASSAM search

Hit pattern: 3D amino acid arrangements similar to known drug binding site

Query pattern: Residues from known binding site for annotated drug that match the hit pattern


(Click link on the last column to view superposed patterns of amino acids in NGL viewer)
(Note that only 3-12 residue patterns can be used for ASSAM searches)
Filter list by:
Hit Macromolecule/
Organism
Pfam Res. Interface HETATM RMSD Dali Z-score Seq. Identity (%) View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1a6c TOBACCO RINGSPOT
VIRUS CAPSID PROTEIN


(Tobacco
ringspot virus)
PF03391
(Nepo_coat)
PF03688
(Nepo_coat_C)
PF03689
(Nepo_coat_N)
5 SER A  45
THR A  59
ILE A  33
PHE A  58
HIS A 163
None
1.32A 4c49C-1a6cA:
0.0
4c49C-1a6cA:
20.19
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1hg8 ENDOPOLYGALACTURONAS
E


(Fusarium
verticillioides)
PF00295
(Glyco_hydro_28)
5 SER A 159
VAL A 132
ILE A 141
SER A 165
PHE A 154
None
1.48A 4c49C-1hg8A:
undetectable
4c49C-1hg8A:
23.08
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ivz HYPOTHETICAL PROTEIN
1110008I14RIK


(Mus musculus)
PF01390
(SEA)
5 PHE A  61
ARG A  96
ILE A  99
PHE A  87
HIS A  13
None
1.42A 4c49C-1ivzA:
0.0
4c49C-1ivzA:
18.68
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1k38 BETA-LACTAMASE OXA-2

(Salmonella
enterica)
PF00905
(Transpeptidase)
5 SER A 147
GLN A 166
THR A  68
ASN A 143
PHE A  69
None
1.18A 4c49C-1k38A:
0.0
4c49C-1k38A:
18.81
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1kkh MEVALONATE KINASE

(Methanocaldococcus
jannaschii)
PF00288
(GHMP_kinases_N)
PF08544
(GHMP_kinases_C)
5 SER A 129
VAL A 128
THR A  44
ILE A 102
PHE A 100
None
1.35A 4c49C-1kkhA:
0.0
4c49C-1kkhA:
21.14
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1kyo HEAVY CHAIN (VH) OF
FV-FRAGMENT


(Mus musculus)
PF07686
(V-set)
5 GLN J  78
THR J  21
ARG J  98
ILE J  29
PHE J  79
None
1.46A 4c49C-1kyoJ:
0.4
4c49C-1kyoJ:
16.37
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1led WEST-CENTRAL AFRICAN
LEGUME LECTIN IV


(Griffonia
simplicifolia)
PF00139
(Lectin_legB)
5 SER A 190
PHE A  93
ILE A 176
PHE A  76
HIS A 233
None
1.41A 4c49C-1ledA:
0.0
4c49C-1ledA:
20.94
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1m72 CASPASE-1

(Spodoptera
frugiperda)
PF00656
(Peptidase_C14)
5 VAL A 131
THR A 159
ILE A 115
PHE A 158
TRP A 155
None
1.21A 4c49C-1m72A:
0.0
4c49C-1m72A:
22.19
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1mqq ALPHA-D-GLUCURONIDAS
E


(Geobacillus
stearothermophilus)
PF03648
(Glyco_hydro_67N)
PF07477
(Glyco_hydro_67C)
PF07488
(Glyco_hydro_67M)
5 SER A 444
VAL A 443
PHE A 320
PHE A 365
HIS A 527
None
None
GCU  A 701 (-3.8A)
None
GOL  A 753 (-4.0A)
1.45A 4c49C-1mqqA:
undetectable
4c49C-1mqqA:
19.51
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1naa CELLOBIOSE
DEHYDROGENASE


(Phanerochaete
chrysosporium)
PF00732
(GMC_oxred_N)
PF05199
(GMC_oxred_C)
5 SER A 654
VAL A 653
ILE A 606
PHE A 524
HIS A 526
None
1.25A 4c49C-1naaA:
undetectable
4c49C-1naaA:
19.78
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1nsa PROCARBOXYPEPTIDASE
B


(Sus scrofa)
PF00246
(Peptidase_M14)
PF02244
(Propep_M14)
5 VAL A  64
PHE A  37
ARG A  33
ILE A  35
HIS A  27
None
1.46A 4c49C-1nsaA:
undetectable
4c49C-1nsaA:
21.56
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1oq1 PROTEIN YESU

(Bacillus
subtilis)
PF09224
(DUF1961)
5 SER A  17
VAL A  19
GLN A 201
ILE A  30
PHE A  50
None
1.44A 4c49C-1oq1A:
undetectable
4c49C-1oq1A:
19.31
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1r8w GLYCEROL DEHYDRATASE

(Clostridium
butyricum)
PF01228
(Gly_radical)
PF02901
(PFL-like)
5 VAL A 563
GLN A 494
ILE A 461
SER A 463
PHE A 487
None
1.46A 4c49C-1r8wA:
undetectable
4c49C-1r8wA:
18.47
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1w61 B-CELL MITOGEN

(Trypanosoma
cruzi)
PF05544
(Pro_racemase)
5 VAL A 271
GLN A 195
ARG A 248
ILE A 251
ASN A 252
None
1.37A 4c49C-1w61A:
undetectable
4c49C-1w61A:
23.67
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1woq INORGANIC
POLYPHOSPHATE/ATP-GL
UCOMANNOKINASE


(Arthrobacter
sp. KM)
PF00480
(ROK)
5 SER A 184
PHE A 218
ILE A 147
PHE A 206
HIS A 208
None
1.17A 4c49C-1woqA:
undetectable
4c49C-1woqA:
22.34
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1z5v TUBULIN GAMMA-1
CHAIN


(Homo sapiens)
PF00091
(Tubulin)
PF03953
(Tubulin_C)
5 SER A 140
VAL A 171
GLN A 230
ILE A 228
SER A 226
GSP  A2466 (-3.1A)
None
None
GSP  A2466 (-4.5A)
None
1.23A 4c49C-1z5vA:
undetectable
4c49C-1z5vA:
21.06
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2a9f PUTATIVE MALIC
ENZYME
((S)-MALATE:NAD+
OXIDOREDUCTASE
(DECARBOXYLATING))


(Streptococcus
pyogenes)
PF00390
(malic)
PF03949
(Malic_M)
5 SER A 185
VAL A 189
PHE A 286
ILE A 175
PHE A 262
None
1.05A 4c49C-2a9fA:
undetectable
4c49C-2a9fA:
22.62
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2akz GAMMA ENOLASE

(Homo sapiens)
PF00113
(Enolase_C)
PF03952
(Enolase_N)
5 VAL A 349
GLN A 408
THR A 378
ILE A 133
PHE A 379
None
1.19A 4c49C-2akzA:
undetectable
4c49C-2akzA:
22.03
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2av9 THIOESTERASE

(Pseudomonas
aeruginosa)
PF03061
(4HBT)
5 VAL A  31
GLN A  16
THR A  42
ILE A  82
PHE A  39
None
1.28A 4c49C-2av9A:
undetectable
4c49C-2av9A:
18.37
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2bo9 HUMAN LATEXIN

(Homo sapiens)
PF06907
(Latexin)
5 VAL B  58
PHE B  89
ILE B  21
ASN B  22
PHE B  91
None
1.35A 4c49C-2bo9B:
undetectable
4c49C-2bo9B:
18.57
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2c5q RRAA-LIKE PROTEIN
YER010C


(Saccharomyces
cerevisiae)
PF03737
(RraA-like)
5 VAL A 116
GLN A 167
THR A 161
ILE A 169
PHE A 118
None
EDO  A1234 (-3.6A)
None
CME  A 170 ( 3.9A)
None
1.41A 4c49C-2c5qA:
undetectable
4c49C-2c5qA:
22.19
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2dwz 26S PROTEASE
REGULATORY SUBUNIT
6B


(Rattus
norvegicus)
no annotation 5 SER B 371
THR B 349
PHE B 399
ILE B 378
PHE B 345
None
1.45A 4c49C-2dwzB:
undetectable
4c49C-2dwzB:
12.53
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2f3n SH3 AND MULTIPLE
ANKYRIN REPEAT
DOMAINS 3


(Rattus
norvegicus)
PF00536
(SAM_1)
5 VAL A  49
ARG A  55
ILE A  58
PHE A  26
HIS A  35
None
1.41A 4c49C-2f3nA:
undetectable
4c49C-2f3nA:
10.91
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2fv5 ADAM 17

(Homo sapiens)
PF13688
(Reprolysin_5)
5 VAL A 364
THR A 404
ILE A 458
SER A 454
HIS A 405
None
None
None
None
ZN  A   3 ( 3.2A)
1.26A 4c49C-2fv5A:
undetectable
4c49C-2fv5A:
22.98
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2hv2 HYPOTHETICAL PROTEIN

(Enterococcus
faecalis)
PF13527
(Acetyltransf_9)
PF13530
(SCP2_2)
5 VAL A 214
THR A 222
ILE A 243
PHE A 223
HIS A 254
None
1.41A 4c49C-2hv2A:
undetectable
4c49C-2hv2A:
21.18
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2nn3 CASPASE-1

(Spodoptera
frugiperda)
PF00656
(Peptidase_C14)
5 VAL C 131
THR C 159
ILE C 115
PHE C 158
TRP C 155
None
1.29A 4c49C-2nn3C:
undetectable
4c49C-2nn3C:
20.91
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2nvu MALTOSE BINDING
PROTEIN/NEDD8-ACTIVA
TING ENZYME E1
CATALYTIC SUBUNIT
CHIMERA
NEDD8-CONJUGATING
ENZYME UBC12


(Homo sapiens)
PF00179
(UQ_con)
PF00899
(ThiF)
PF08825
(E2_bind)
PF13416
(SBP_bac_8)
5 SER B2396
PHE C  80
ILE C 125
ASN C 126
PHE C  60
None
1.33A 4c49C-2nvuB:
undetectable
4c49C-2nvuB:
18.19
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2omo DUF176

(Nitrosomonas
europaea)
PF03992
(ABM)
5 THR A  22
ARG A  37
ILE A  30
ASN A  35
SER A  29
None
1.43A 4c49C-2omoA:
undetectable
4c49C-2omoA:
16.47
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2pg6 CYTOCHROME P450 2A6

(Homo sapiens)
PF00067
(p450)
5 SER A 175
THR A 212
PHE A 107
ILE A 300
PHE A 209
None
1.47A 4c49C-2pg6A:
undetectable
4c49C-2pg6A:
21.49
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2r0b SERINE/THREONINE/TYR
OSINE-INTERACTING
PROTEIN


(Homo sapiens)
PF00782
(DSPc)
5 THR A 102
PHE A 130
ILE A  95
ASN A  94
PHE A  99
None
1.24A 4c49C-2r0bA:
undetectable
4c49C-2r0bA:
18.28
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2v95 CORTICOSTEROID-BINDI
NG GLOBULIN


(Rattus
norvegicus)
PF00079
(Serpin)
8 VAL A  17
GLN A 224
THR A 232
PHE A 234
ARG A 252
ILE A 255
PHE A 357
TRP A 362
HCY  A1375 ( 4.8A)
HCY  A1375 (-3.5A)
HCY  A1375 ( 4.2A)
HCY  A1375 (-4.8A)
HCY  A1375 (-4.9A)
None
HCY  A1375 ( 4.1A)
HCY  A1375 (-3.8A)
0.65A 4c49C-2v95A:
39.2
4c49C-2v95A:
61.39
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2ve3 PUTATIVE CYTOCHROME
P450 120


(Synechocystis
sp. PCC 6803)
PF00067
(p450)
5 SER A 429
THR A  26
PHE A  52
SER A  83
PHE A  29
REA  A1445 ( 4.3A)
None
None
None
REA  A1445 (-4.6A)
1.35A 4c49C-2ve3A:
undetectable
4c49C-2ve3A:
23.71
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2vsm HEMAGGLUTININ-NEURAM
INIDASE


(Nipah
henipavirus)
PF00423
(HN)
5 SER A 411
VAL A 367
THR A 308
ILE A 304
PHE A 369
None
1.20A 4c49C-2vsmA:
undetectable
4c49C-2vsmA:
21.32
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2w3j CARBOHYDRATE BINDING
MODULE


(uncultured
bacterium)
PF16990
(CBM_35)
5 VAL A  71
GLN A  93
PHE A  59
ILE A  57
PHE A  83
None
1.26A 4c49C-2w3jA:
undetectable
4c49C-2w3jA:
18.77
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2x7j 2-SUCCINYL-5-ENOLPYR
UVYL-6-HYDROXY-3-CYC
LOHEXENE
-1-CARBOXYLATE
SYNTHASE


(Bacillus
subtilis)
PF02775
(TPP_enzyme_C)
PF02776
(TPP_enzyme_N)
PF16582
(TPP_enzyme_M_2)
5 VAL A 394
ILE A 424
ASN A 256
SER A 255
PHE A 415
None
1.39A 4c49C-2x7jA:
undetectable
4c49C-2x7jA:
22.41
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2xax RIBONUCLEOSIDE-DIPHO
SPHATE REDUCTASE 1
SUBUNIT ALPHA


(Escherichia
coli)
PF00317
(Ribonuc_red_lgN)
PF02867
(Ribonuc_red_lgC)
PF03477
(ATP-cone)
5 PHE A 285
ILE A 237
ASN A 238
SER A 241
PHE A 281
None
1.38A 4c49C-2xaxA:
undetectable
4c49C-2xaxA:
19.73
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2xax RIBONUCLEOSIDE-DIPHO
SPHATE REDUCTASE 1
SUBUNIT ALPHA


(Escherichia
coli)
PF00317
(Ribonuc_red_lgN)
PF02867
(Ribonuc_red_lgC)
PF03477
(ATP-cone)
5 THR A 276
PHE A 281
ILE A 237
ASN A 238
PHE A 274
None
1.28A 4c49C-2xaxA:
undetectable
4c49C-2xaxA:
19.73
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2xf8 D-ERYTHROSE-4-PHOSPH
ATE DEHYDROGENASE


(Escherichia
coli)
PF00044
(Gp_dh_N)
PF02800
(Gp_dh_C)
5 VAL A 172
GLN A 220
PHE A 221
ILE A 158
PHE A 225
None
1.41A 4c49C-2xf8A:
undetectable
4c49C-2xf8A:
22.56
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2zxq ENDO-ALPHA-N-ACETYLG
ALACTOSAMINIDASE


(Bifidobacterium
longum)
PF12905
(Glyco_hydro_101)
PF17451
(Glyco_hyd_101C)
5 VAL A1463
PHE A1506
ARG A1493
ILE A1496
ASN A1497
None
1.08A 4c49C-2zxqA:
undetectable
4c49C-2zxqA:
14.33
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3afl OLIGO ALGINATE LYASE

(Agrobacterium
fabrum)
PF07940
(Hepar_II_III)
PF16332
(DUF4962)
5 SER A 650
GLN A 656
THR A 721
ILE A 578
ASN A 623
None
1.35A 4c49C-3aflA:
undetectable
4c49C-3aflA:
19.74
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3e1k GALACTOSE/LACTOSE
METABOLISM
REGULATORY PROTEIN
GAL80


(Kluyveromyces
lactis)
PF01408
(GFO_IDH_MocA)
5 VAL A 440
PHE A 280
ASN A 206
PHE A 212
HIS A 214
None
1.38A 4c49C-3e1kA:
undetectable
4c49C-3e1kA:
21.84
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3e1k GALACTOSE/LACTOSE
METABOLISM
REGULATORY PROTEIN
GAL80


(Kluyveromyces
lactis)
PF01408
(GFO_IDH_MocA)
5 VAL A 440
THR A 215
PHE A 280
ASN A 206
HIS A 214
None
1.33A 4c49C-3e1kA:
undetectable
4c49C-3e1kA:
21.84
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3eqn GLUCAN
1,3-BETA-GLUCOSIDASE


(Phanerochaete
chrysosporium)
PF12708
(Pectate_lyase_3)
5 SER A 152
VAL A 153
GLN A 196
THR A 168
HIS A 171
None
1.44A 4c49C-3eqnA:
undetectable
4c49C-3eqnA:
18.87
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3l1c KINESIN-14 NCD

(Drosophila
melanogaster)
PF00225
(Kinesin)
5 SER A 416
VAL A 415
ILE A 411
SER A 406
PHE A 644
None
1.47A 4c49C-3l1cA:
undetectable
4c49C-3l1cA:
23.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3llr DNA
(CYTOSINE-5)-METHYLT
RANSFERASE 3A


(Homo sapiens)
PF00855
(PWWP)
5 SER A 103
PHE A  80
ILE A 133
ASN A 129
PHE A  76
None
1.44A 4c49C-3llrA:
undetectable
4c49C-3llrA:
18.43
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3psf TRANSCRIPTION
ELONGATION FACTOR
SPT6


(Saccharomyces
cerevisiae)
PF14635
(HHH_7)
PF14639
(YqgF)
PF14641
(HTH_44)
PF14878
(DLD)
5 SER A 917
THR A 731
ILE A 904
PHE A 729
HIS A 727
None
1.24A 4c49C-3psfA:
undetectable
4c49C-3psfA:
16.47
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3psi TRANSCRIPTION
ELONGATION FACTOR
SPT6


(Saccharomyces
cerevisiae)
PF14635
(HHH_7)
PF14639
(YqgF)
PF14641
(HTH_44)
PF14878
(DLD)
5 SER A 917
THR A 731
ILE A 904
PHE A 729
HIS A 727
None
1.31A 4c49C-3psiA:
undetectable
4c49C-3psiA:
15.14
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3qnb OXACILLINASE

(Escherichia
coli)
PF00905
(Transpeptidase)
5 SER A 147
GLN A 166
THR A  68
ASN A 143
PHE A  69
None
1.27A 4c49C-3qnbA:
undetectable
4c49C-3qnbA:
21.16
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3sx2 PUTATIVE
3-KETOACYL-(ACYL-CAR
RIER-PROTEIN)
REDUCTASE


(Mycobacterium
avium)
PF13561
(adh_short_C2)
5 SER A  49
VAL A  50
GLN A  23
THR A 208
ASN A 127
None
None
NAD  A 300 (-3.3A)
NAD  A 300 (-2.8A)
NAD  A 300 ( 4.6A)
1.44A 4c49C-3sx2A:
undetectable
4c49C-3sx2A:
21.59
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3t6q CD180 ANTIGEN

(Mus musculus)
PF13855
(LRR_8)
5 SER A 535
GLN A 493
ILE A 486
ASN A 485
PHE A 516
None
1.29A 4c49C-3t6qA:
undetectable
4c49C-3t6qA:
21.20
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ti2 3-PHOSPHOSHIKIMATE
1-CARBOXYVINYLTRANSF
ERASE


(Vibrio cholerae)
PF00275
(EPSP_synthase)
5 SER A  23
VAL A  24
THR A  39
ARG A  27
PHE A 238
None
None
None
CL  A   1 ( 3.0A)
None
1.37A 4c49C-3ti2A:
undetectable
4c49C-3ti2A:
23.95
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3u1k POLYRIBONUCLEOTIDE
NUCLEOTIDYLTRANSFERA
SE 1, MITOCHONDRIAL


(Homo sapiens)
PF00013
(KH_1)
PF01138
(RNase_PH)
PF03725
(RNase_PH_C)
PF03726
(PNPase)
5 VAL A 313
THR A 287
ASN A 540
PHE A 340
HIS A 288
None
1.42A 4c49C-3u1kA:
undetectable
4c49C-3u1kA:
21.95
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3vvw CALCIUM-BINDING AND
COILED-COIL
DOMAIN-CONTAINING
PROTEIN 2


(Homo sapiens)
PF07888
(CALCOCO1)
5 VAL A  23
PHE A 107
ILE A  56
PHE A  25
HIS A  41
None
1.20A 4c49C-3vvwA:
undetectable
4c49C-3vvwA:
14.91
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3zgx CHROMOSOME PARTITION
PROTEIN SMC


(Bacillus
subtilis)
PF02463
(SMC_N)
5 VAL A1072
THR A1036
ARG A 157
SER A1104
PHE A1037
None
1.48A 4c49C-3zgxA:
undetectable
4c49C-3zgxA:
23.85
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3zpm LATHERIN

(Equus caballus)
PF01273
(LBP_BPI_CETP)
5 SER A  93
VAL A  94
GLN A  43
THR A  39
ILE A 159
None
1.36A 4c49C-3zpmA:
undetectable
4c49C-3zpmA:
22.25
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4a22 FRUCTOSE-BISPHOSPHAT
E ALDOLASE


(Mycobacterium
tuberculosis)
PF01116
(F_bP_aldolase)
5 SER A  31
VAL A  34
THR A  94
PHE A 125
PHE A  52
None
None
NA  A1347 (-3.6A)
None
None
1.41A 4c49C-4a22A:
undetectable
4c49C-4a22A:
20.00
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4c41 CORTICOSTEROID-BINDI
NG GLOBULIN


(Homo sapiens)
PF00079
(Serpin)
5 GLN A 232
THR A 240
PHE A 242
ASN A 264
SER A 267
None
0.84A 4c49C-4c41A:
58.2
4c49C-4c41A:
99.46
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4c41 CORTICOSTEROID-BINDI
NG GLOBULIN


(Homo sapiens)
PF00079
(Serpin)
5 THR A 240
PHE A 242
ASN A 264
SER A 267
HIS A 368
None
1.03A 4c49C-4c41A:
58.2
4c49C-4c41A:
99.46
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4c41 CORTICOSTEROID-BINDI
NG GLOBULIN


(Homo sapiens)
PF00079
(Serpin)
7 VAL A  22
GLN A 232
THR A 240
PHE A 242
ILE A 263
ASN A 264
PHE A 366
None
0.67A 4c49C-4c41A:
58.2
4c49C-4c41A:
99.46
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4c41 CORTICOSTEROID-BINDI
NG GLOBULIN


(Homo sapiens)
PF00079
(Serpin)
6 VAL A  22
THR A 240
PHE A 242
ASN A 264
PHE A 366
HIS A 368
None
0.82A 4c49C-4c41A:
58.2
4c49C-4c41A:
99.46
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4dji PROBABLE
GLUTAMATE/GAMMA-AMIN
OBUTYRATE ANTIPORTER


(Escherichia
coli)
PF13520
(AA_permease_2)
5 VAL A 110
GLN A 345
THR A 349
PHE A 103
ILE A 305
None
1.29A 4c49C-4djiA:
undetectable
4c49C-4djiA:
24.71
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ej0 ADP-L-GLYCERO-D-MANN
O-HEPTOSE-6-EPIMERAS
E


(Burkholderia
thailandensis)
PF01370
(Epimerase)
5 SER A  97
VAL A 100
PHE A  66
ILE A   4
PHE A  61
None
1.37A 4c49C-4ej0A:
undetectable
4c49C-4ej0A:
22.60
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4gn2 OXACILLINASE

(Pseudomonas
aeruginosa)
PF00905
(Transpeptidase)
5 SER A 144
GLN A 169
THR A  64
ASN A 140
PHE A  65
None
1.29A 4c49C-4gn2A:
undetectable
4c49C-4gn2A:
20.32
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4i95 PUTATIVE
UNCHARACTERIZED
PROTEIN


(Bacteroides
eggerthii)
PF14869
(DUF4488)
5 GLN A  38
PHE A  59
ARG A  74
ILE A  73
HIS A  41
None
1.38A 4c49C-4i95A:
undetectable
4c49C-4i95A:
17.20
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ilr CRISPR-ASSOCIATED
ENDORIBONUCLEASE
CAS6 2


(Sulfolobus
solfataricus)
PF10040
(CRISPR_Cas6)
5 SER A 149
ILE A 203
ASN A 206
SER A 205
PHE A 199
None
1.31A 4c49C-4ilrA:
undetectable
4c49C-4ilrA:
21.76
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4l1y SALIVARY NITROPHORIN

(Cimex
lectularius)
no annotation 5 SER A 157
THR A  11
PHE A 278
ILE A 255
PHE A 167
None
1.37A 4c49C-4l1yA:
undetectable
4c49C-4l1yA:
21.26
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4mll BETA-LACTAMASE OXA-1

(Escherichia
coli)
PF00905
(Transpeptidase)
5 SER A 147
GLN A 172
THR A  68
ASN A 143
PHE A  69
None
1.31A 4c49C-4mllA:
undetectable
4c49C-4mllA:
23.86
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4mn8 LRR RECEPTOR-LIKE
SERINE/THREONINE-PRO
TEIN KINASE FLS2


(Arabidopsis
thaliana)
PF00560
(LRR_1)
PF08263
(LRRNT_2)
PF13516
(LRR_6)
PF13855
(LRR_8)
5 THR A 603
ILE A 606
ASN A 609
SER A 607
PHE A 604
None
1.40A 4c49C-4mn8A:
undetectable
4c49C-4mn8A:
19.49
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4mna LRR RECEPTOR-LIKE
SERINE/THREONINE-PRO
TEIN KINASE FLS2


(Arabidopsis
thaliana)
PF00560
(LRR_1)
PF08263
(LRRNT_2)
PF13516
(LRR_6)
PF13855
(LRR_8)
5 THR A 603
ILE A 606
ASN A 609
SER A 607
PHE A 604
None
None
None
NAG  A 902 (-2.9A)
None
1.46A 4c49C-4mnaA:
undetectable
4c49C-4mnaA:
20.57
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4mt1 DRUG EFFLUX PROTEIN

(Neisseria
gonorrhoeae)
PF00873
(ACR_tran)
5 SER A1025
VAL A1026
PHE A 517
ILE A 983
PHE A 979
None
1.41A 4c49C-4mt1A:
undetectable
4c49C-4mt1A:
16.70
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4pfw ABC TRANSPORTER
SUBSTRATE-BINDING
PROTEIN


(Thermotoga
maritima)
PF00496
(SBP_bac_5)
5 VAL A 213
ARG A  92
ILE A  95
HIS A  98
TRP A 208
None
1.47A 4c49C-4pfwA:
undetectable
4c49C-4pfwA:
21.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4s3l MAJOR PILIN PROTEIN

(Streptococcus
pneumoniae)
no annotation 5 SER A 337
PHE A 305
ILE A 244
ASN A 371
PHE A 261
None
1.35A 4c49C-4s3lA:
undetectable
4c49C-4s3lA:
20.47
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4zhj MG-CHELATASE SUBUNIT
CHLH


(Synechocystis
sp. PCC 6803)
PF02514
(CobN-Mg_chel)
PF11965
(DUF3479)
5 SER A1101
THR A 470
ILE A 663
SER A 659
HIS A1174
None
1.29A 4c49C-4zhjA:
undetectable
4c49C-4zhjA:
14.75
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4zke SUPERKILLER PROTEIN
7


(Saccharomyces
cerevisiae)
PF00009
(GTP_EFTU)
5 GLN A 568
THR A 681
PHE A 715
ILE A 710
HIS A 678
GLN  A 568 ( 0.6A)
THR  A 681 ( 0.8A)
PHE  A 715 ( 1.3A)
ILE  A 710 ( 0.7A)
HIS  A 678 ( 1.0A)
1.06A 4c49C-4zkeA:
undetectable
4c49C-4zkeA:
23.27
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5amq RNA POLYMERASE L

(California
encephalitis
orthobunyavirus)
PF04196
(Bunya_RdRp)
PF15518
(L_protein_N)
5 SER A 330
PHE A 545
ILE A 543
SER A 560
HIS A 578
None
1.37A 4c49C-5amqA:
undetectable
4c49C-5amqA:
10.66
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5bu6 BPSB (PGAB),
POLY-BETA-1,6-N-ACET
YL-D-GLUCOSAMINE
N-DEACETYLASE


(Bordetella
bronchiseptica)
PF01522
(Polysacc_deac_1)
5 SER A  47
THR A  42
ARG A 290
ILE A 288
PHE A  43
None
None
SCN  A 404 (-4.1A)
None
None
1.22A 4c49C-5bu6A:
undetectable
4c49C-5bu6A:
21.35
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5but KTR SYSTEM POTASSIUM
UPTAKE PROTEIN B


(Bacillus
subtilis)
PF02386
(TrkH)
5 SER I 187
PHE I 202
ILE I 198
ASN I 195
PHE I 281
None
1.33A 4c49C-5butI:
undetectable
4c49C-5butI:
23.34
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ctm BETA-LACTAMASE

(Bacillus
pumilus)
PF00905
(Transpeptidase)
5 SER A 181
GLN A 200
THR A 102
ASN A 177
PHE A 103
None
1.33A 4c49C-5ctmA:
undetectable
4c49C-5ctmA:
20.98
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5d2n C25 BETA

(Homo sapiens)
no annotation 5 SER F   7
GLN F  54
THR F  47
PHE F  49
ARG F  22
None
1.01A 4c49C-5d2nF:
undetectable
4c49C-5d2nF:
23.38
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5d5t UNCHARACTERIZED
PROTEIN MJ0489


(Methanocaldococcus
jannaschii)
PF06690
(DUF1188)
5 SER A 263
VAL A 265
THR A 159
PHE A 136
ILE A 137
None
1.40A 4c49C-5d5tA:
undetectable
4c49C-5d5tA:
20.51
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5d9a POLYMERASE BASIC
PROTEIN 2


(Influenza C
virus)
PF00604
(Flu_PB2)
5 SER C 317
VAL C 320
THR C 295
ARG C 267
ILE C 266
None
1.37A 4c49C-5d9aC:
undetectable
4c49C-5d9aC:
20.29
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5dz7 POLYKETIDE
BIOSYNTHESIS PROTEIN
PKSE


(Bacillus
subtilis)
PF00698
(Acyl_transf_1)
5 THR A  54
PHE A 192
ILE A 119
SER A 189
HIS A  53
None
GOL  A 303 (-4.2A)
None
None
None
1.26A 4c49C-5dz7A:
undetectable
4c49C-5dz7A:
23.20
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5e2f BETA-LACTAMASE YBXI

(Bacillus
subtilis)
PF00905
(Transpeptidase)
5 SER A 156
GLN A 175
THR A  77
ASN A 152
PHE A  78
None
1.38A 4c49C-5e2fA:
undetectable
4c49C-5e2fA:
19.53
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5erd DESMOGLEIN-2

(Homo sapiens)
PF00028
(Cadherin)
5 SER A 148
GLN A 112
PHE A 115
ILE A 132
PHE A 110
None
1.32A 4c49C-5erdA:
undetectable
4c49C-5erdA:
21.07
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ern FUSICOCCADIENE
SYNTHASE


(Diaporthe
amygdali)
PF00348
(polyprenyl_synt)
5 VAL A  77
THR A 208
PHE A  55
ILE A  56
HIS A 205
None
1.23A 4c49C-5ernA:
undetectable
4c49C-5ernA:
22.06
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5fub PROTEIN ARGININE
METHYLTRANSFERASE 2


(Danio rerio)
PF13649
(Methyltransf_25)
5 VAL A 187
GLN A 105
ILE A 107
ASN A 110
SER A 109
None
1.31A 4c49C-5fubA:
undetectable
4c49C-5fubA:
24.88
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5hx6 RECEPTOR-INTERACTING
SERINE/THREONINE-PRO
TEIN KINASE 1


(Homo sapiens)
PF07714
(Pkinase_Tyr)
5 SER A  73
PHE A 278
ARG A  74
ILE A 123
HIS A 136
None
None
None
None
65U  A 301 (-3.3A)
1.46A 4c49C-5hx6A:
undetectable
4c49C-5hx6A:
21.20
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5i6c URIC ACID-XANTHINE
PERMEASE


(Aspergillus
nidulans)
PF00860
(Xan_ur_permease)
5 SER A 154
VAL A 153
GLN A 112
ILE A 101
SER A 103
XAN  A1001 (-3.5A)
None
None
None
None
1.38A 4c49C-5i6cA:
undetectable
4c49C-5i6cA:
20.31
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5idu ACYL-COA
DEHYDROGENASE DOMAIN
PROTEIN


(Paraburkholderia
phymatum)
PF00441
(Acyl-CoA_dh_1)
PF02770
(Acyl-CoA_dh_M)
PF02771
(Acyl-CoA_dh_N)
5 SER A 127
VAL A 126
GLN A 233
ILE A 110
PHE A 177
None
1.22A 4c49C-5iduA:
undetectable
4c49C-5iduA:
20.09
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5in2 EXTRACELLULAR
SUPEROXIDE DISMUTASE
[CU-ZN]


(Onchocerca
volvulus)
PF00080
(Sod_Cu)
5 SER A  15
VAL A  35
ILE A  18
PHE A  45
HIS A  48
GOL  A 201 (-3.4A)
None
None
None
CU  A 203 ( 3.2A)
1.46A 4c49C-5in2A:
undetectable
4c49C-5in2A:
18.38
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5j5j DESMOCOLLIN-2,DESMOG
LEIN-2


(Homo sapiens)
PF00028
(Cadherin)
5 SER A 146
GLN A 110
PHE A 113
ILE A 130
PHE A 108
None
1.35A 4c49C-5j5jA:
undetectable
4c49C-5j5jA:
19.89
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5j72 PUTATIVE
N-ACETYLMURAMOYL-L-A
LANINE
AMIDASE,AUTOLYSIN
CWP6


(Clostridioides
difficile)
PF01520
(Amidase_3)
PF04122
(CW_binding_2)
5 SER A 444
THR A 403
ILE A 436
ASN A 437
SER A 434
None
1.37A 4c49C-5j72A:
undetectable
4c49C-5j72A:
20.97
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5j72 PUTATIVE
N-ACETYLMURAMOYL-L-A
LANINE
AMIDASE,AUTOLYSIN
CWP6


(Clostridioides
difficile)
PF01520
(Amidase_3)
PF04122
(CW_binding_2)
5 VAL A 424
THR A 403
ILE A 436
ASN A 437
SER A 434
None
1.20A 4c49C-5j72A:
undetectable
4c49C-5j72A:
20.97
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5oar BETA-HEXOSAMINIDASE

(Aspergillus
oryzae)
no annotation 5 SER A  50
THR B 154
ILE B 141
PHE B 153
HIS B 151
None
1.44A 4c49C-5oarA:
undetectable
4c49C-5oarA:
11.88
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5t9p RIBOSOME BIOGENESIS
PROTEIN 15


(Saccharomyces
cerevisiae)
no annotation 5 SER B  96
VAL B  95
GLN B 113
PHE B 114
PHE B 111
CL  B 206 ( 4.6A)
None
None
None
None
1.36A 4c49C-5t9pB:
undetectable
4c49C-5t9pB:
19.09
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5u03 CTP SYNTHASE 1

(Homo sapiens)
PF00117
(GATase)
PF06418
(CTP_synth_N)
5 SER A  22
VAL A  23
GLN A 240
ILE A 178
PHE A 266
None
1.44A 4c49C-5u03A:
undetectable
4c49C-5u03A:
19.59
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5wde KINESIN-LIKE PROTEIN
KIFC3


(Homo sapiens)
PF00225
(Kinesin)
5 SER A 746
VAL A 452
ILE A 479
SER A 489
PHE A 471
None
None
None
UNX  A 920 ( 4.4A)
None
1.38A 4c49C-5wdeA:
undetectable
4c49C-5wdeA:
22.11
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5yww NUCLEOTIDE BINDING
PROTEIN PINC


(Sulfolobus
islandicus)
no annotation 5 SER A 168
VAL A 171
ARG A 172
ILE A 209
SER A 197
None
1.37A 4c49C-5ywwA:
undetectable
4c49C-5ywwA:
12.24
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5znn SORTILIN

(Mus musculus)
no annotation 5 SER A 478
VAL A 486
ILE A 413
SER A 415
HIS A 461
None
1.39A 4c49C-5znnA:
undetectable
4c49C-5znnA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6bqw BACTERIAL ACTIN ALFA

(Bacillus
subtilis)
no annotation 5 SER A 189
VAL A 176
ILE A 215
ASN A 214
PHE A 208
None
1.27A 4c49C-6bqwA:
undetectable
4c49C-6bqwA:
16.67