SIMILAR PATTERNS OF AMINO ACIDS FOR 4C49_A_HCYA1384_1

List of similar pattern of amino acids derived from ASSAM search

Hit pattern: 3D amino acid arrangements similar to known drug binding site

Query pattern: Residues from known binding site for annotated drug that match the hit pattern


(Click link on the last column to view superposed patterns of amino acids in NGL viewer)
(Note that only 3-12 residue patterns can be used for ASSAM searches)
Filter list by:
Hit Macromolecule/
Organism
Pfam Res. Interface HETATM RMSD Dali Z-score Seq. Identity (%) View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1agx GLUTAMINASE-ASPARAGI
NASE


(Acinetobacter
glutaminasificans)
PF00710
(Asparaginase)
5 ALA A 135
SER A 134
THR A   9
ILE A  13
HIS A  90
None
1.22A 4c49A-1agxA:
0.0
4c49A-1agxA:
21.77
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1at3 HERPES SIMPLEX VIRUS
TYPE II PROTEASE


(Human
alphaherpesvirus
2)
PF00716
(Peptidase_S21)
5 SER A 129
VAL A 128
ILE A  57
ASN A  58
PHE A  82
DFP  A 300 ( 1.5A)
None
None
None
None
1.30A 4c49A-1at3A:
undetectable
4c49A-1at3A:
20.53
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1i74 PROBABLE
MANGANESE-DEPENDENT
INORGANIC
PYROPHOSPHATASE


(Streptococcus
mutans)
PF01368
(DHH)
PF02833
(DHHA2)
5 ALA A  68
VAL A  71
GLN A   9
ILE A  86
PHE A   6
None
1.11A 4c49A-1i74A:
undetectable
4c49A-1i74A:
22.61
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1j3n 3-OXOACYL-(ACYL-CARR
IER PROTEIN)
SYNTHASE II


(Thermus
thermophilus)
PF00109
(ketoacyl-synt)
PF02801
(Ketoacyl-synt_C)
5 ALA A 165
GLN A  26
THR A 332
PHE A  22
ILE A 349
None
1.26A 4c49A-1j3nA:
0.0
4c49A-1j3nA:
21.87
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1k20 MANGANESE-DEPENDENT
INORGANIC
PYROPHOSPHATASE


(Streptococcus
gordonii)
PF01368
(DHH)
PF02833
(DHHA2)
5 ALA A  70
VAL A  73
GLN A  10
ILE A  88
PHE A   7
None
1.23A 4c49A-1k20A:
undetectable
4c49A-1k20A:
21.92
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1li7 CYSTEINYL-TRNA
SYNTHETASE


(Escherichia
coli)
PF01406
(tRNA-synt_1e)
PF09190
(DALR_2)
5 ALA A  46
VAL A  50
THR A   7
ILE A 223
HIS A 256
None
1.16A 4c49A-1li7A:
0.0
4c49A-1li7A:
22.27
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ljy MGP-40

(Capra hircus)
PF00704
(Glyco_hydro_18)
5 SER A 181
VAL A 157
GLN A 172
ILE A 170
HIS A 176
None
1.16A 4c49A-1ljyA:
0.0
4c49A-1ljyA:
21.27
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1m32 2-AMINOETHYLPHOSPHON
ATE-PYRUVATE
AMINOTRANSFERASE


(Salmonella
enterica)
PF00266
(Aminotran_5)
5 ALA A 280
SER A 277
PHE A 338
ILE A 340
PHE A 303
None
1.19A 4c49A-1m32A:
0.0
4c49A-1m32A:
22.12
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1n8y PROTOONCOPROTEIN

(Rattus
norvegicus)
PF00757
(Furin-like)
PF01030
(Recep_L_domain)
PF14843
(GF_recep_IV)
5 ALA C 393
SER C 392
GLN C 375
ILE C 335
SER C 337
None
1.22A 4c49A-1n8yC:
0.0
4c49A-1n8yC:
20.37
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1p1v SUPEROXIDE DISMUTASE
[CU-ZN]


(Homo sapiens)
PF00080
(Sod_Cu)
5 ALA A  95
SER A  34
VAL A  97
PHE A  45
HIS A 120
None
None
None
None
ZN  A 201 ( 3.2A)
1.11A 4c49A-1p1vA:
undetectable
4c49A-1p1vA:
16.98
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1q9j POLYKETIDE SYNTHASE
ASSOCIATED PROTEIN 5


(Mycobacterium
tuberculosis)
PF00668
(Condensation)
PF16911
(PapA_C)
5 ALA A 288
SER A 289
VAL A 263
SER A  13
PHE A 327
None
1.20A 4c49A-1q9jA:
undetectable
4c49A-1q9jA:
20.81
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1r5m SIR4-INTERACTING
PROTEIN SIF2


(Saccharomyces
cerevisiae)
PF00400
(WD40)
PF12894
(ANAPC4_WD40)
5 ALA A 407
VAL A 415
ILE A 385
SER A 393
PHE A 397
None
1.14A 4c49A-1r5mA:
undetectable
4c49A-1r5mA:
23.67
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1sxz PROTEIN (CU-ZN
SUPEROXIDE
DISMUTASE)


(Bos taurus)
PF00080
(Sod_Cu)
5 ALA A  93
SER A  32
VAL A  95
PHE A  43
HIS A 118
None
None
None
None
CU  A 152 (-3.2A)
1.25A 4c49A-1sxzA:
undetectable
4c49A-1sxzA:
17.60
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1u08 HYPOTHETICAL
AMINOTRANSFERASE
YBDL


(Escherichia
coli)
PF00155
(Aminotran_1_2)
5 ALA A 103
VAL A  96
THR A 237
ILE A  76
PHE A 234
None
1.25A 4c49A-1u08A:
undetectable
4c49A-1u08A:
21.76
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1uai POLYGULURONATE LYASE

(Corynebacterium
sp.)
PF08787
(Alginate_lyase2)
5 ALA A  86
SER A  87
PHE A 162
ILE A 118
PHE A 190
None
1.17A 4c49A-1uaiA:
undetectable
4c49A-1uaiA:
21.77
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1uf2 CORE PROTEIN P3

(Rice dwarf
virus)
PF09231
(RDV-p3)
5 SER A 800
ILE A 847
ASN A 783
SER A 848
PHE A 862
None
1.30A 4c49A-1uf2A:
undetectable
4c49A-1uf2A:
18.41
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1vqr HYPOTHETICAL PROTEIN
CJ0248


(Campylobacter
jejuni)
PF08668
(HDOD)
5 ALA A 125
SER A 136
VAL A 140
ILE A  74
ASN A  75
None
1.19A 4c49A-1vqrA:
undetectable
4c49A-1vqrA:
21.41
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1vzv VARICELLA-ZOSTER
VIRUS PROTEASE


(Human
alphaherpesvirus
3)
PF00716
(Peptidase_S21)
5 SER A 120
VAL A 119
ILE A  48
ASN A  49
PHE A  73
None
1.25A 4c49A-1vzvA:
undetectable
4c49A-1vzvA:
20.49
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1woq INORGANIC
POLYPHOSPHATE/ATP-GL
UCOMANNOKINASE


(Arthrobacter
sp. KM)
PF00480
(ROK)
5 ALA A 183
SER A 184
PHE A 218
ILE A 147
PHE A 206
None
1.07A 4c49A-1woqA:
undetectable
4c49A-1woqA:
22.34
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1y56 SARCOSINE OXIDASE

(Pyrococcus
horikoshii)
PF01266
(DAO)
5 ALA B 250
SER B 244
VAL B 242
THR B 230
ILE B 292
None
1.16A 4c49A-1y56B:
undetectable
4c49A-1y56B:
23.24
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1yj8 GLYCEROL-3-PHOSPHATE
DEHYDROGENASE


(Plasmodium
falciparum)
PF01210
(NAD_Gly3P_dh_N)
PF07479
(NAD_Gly3P_dh_C)
5 ALA A  35
SER A  34
ILE A 108
SER A 139
PHE A 203
None
1.21A 4c49A-1yj8A:
undetectable
4c49A-1yj8A:
23.13
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1z5v TUBULIN GAMMA-1
CHAIN


(Homo sapiens)
PF00091
(Tubulin)
PF03953
(Tubulin_C)
5 SER A 140
VAL A 171
GLN A 230
ILE A 228
SER A 226
GSP  A2466 (-3.1A)
None
None
GSP  A2466 (-4.5A)
None
1.28A 4c49A-1z5vA:
undetectable
4c49A-1z5vA:
21.06
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2a2a DEATH-ASSOCIATED
PROTEIN KINASE 2


(Homo sapiens)
PF00069
(Pkinase)
5 ALA A  25
SER A  21
VAL A  27
ILE A 160
ASN A 144
None
None
None
GOL  A3001 ( 3.9A)
None
0.98A 4c49A-2a2aA:
undetectable
4c49A-2a2aA:
21.56
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2a9f PUTATIVE MALIC
ENZYME
((S)-MALATE:NAD+
OXIDOREDUCTASE
(DECARBOXYLATING))


(Streptococcus
pyogenes)
PF00390
(malic)
PF03949
(Malic_M)
5 SER A 185
VAL A 189
PHE A 286
ILE A 175
PHE A 262
None
1.25A 4c49A-2a9fA:
undetectable
4c49A-2a9fA:
22.62
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2aeu HYPOTHETICAL PROTEIN
MJ0158


(Methanocaldococcus
jannaschii)
PF03841
(SelA)
5 ALA A 180
SER A 205
VAL A 203
SER A 117
PHE A 176
SO4  A1001 ( 4.6A)
SO4  A1001 (-2.6A)
None
None
None
1.26A 4c49A-2aeuA:
undetectable
4c49A-2aeuA:
20.65
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2bo9 HUMAN LATEXIN

(Homo sapiens)
PF06907
(Latexin)
5 VAL B  58
PHE B  89
ILE B  21
ASN B  22
PHE B  91
None
1.23A 4c49A-2bo9B:
undetectable
4c49A-2bo9B:
18.57
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2cnd NADH-DEPENDENT
NITRATE REDUCTASE


(Zea mays)
PF00175
(NAD_binding_1)
PF00970
(FAD_binding_6)
5 ALA A 174
VAL A 172
PHE A 267
ASN A 255
SER A 253
None
1.21A 4c49A-2cndA:
undetectable
4c49A-2cndA:
22.75
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2d6l LECTIN, GALACTOSE
BINDING, SOLUBLE 9


(Mus musculus)
PF00337
(Gal-bind_lectin)
5 SER X 136
VAL X  46
GLN X   7
PHE X 146
ILE X 144
None
1.19A 4c49A-2d6lX:
undetectable
4c49A-2d6lX:
19.57
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2ijd PICORNAIN 3C,
RNA-DIRECTED RNA
POLYMERASE


(Enterovirus C)
PF00548
(Peptidase_C3)
PF00680
(RdRP_1)
5 ALA 1 224
THR 1 235
ILE 1 241
SER 1 243
PHE 1 237
None
1.17A 4c49A-2ijd1:
undetectable
4c49A-2ijd1:
20.80
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2jdx PROTEIN
(L-ARGININE:GLYCINE
AMIDINOTRANSFERASE)


(Homo sapiens)
no annotation 5 ALA A 261
THR A 307
PHE A 296
ILE A 294
PHE A 308
None
1.16A 4c49A-2jdxA:
undetectable
4c49A-2jdxA:
23.60
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2nn3 CASPASE-1

(Spodoptera
frugiperda)
PF00656
(Peptidase_C14)
5 VAL C 131
THR C 159
ILE C 115
PHE C 158
TRP C 155
None
1.28A 4c49A-2nn3C:
undetectable
4c49A-2nn3C:
20.91
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2p9b POSSIBLE PROLIDASE

(Bifidobacterium
longum)
PF01979
(Amidohydro_1)
5 ALA A 259
VAL A 261
THR A 207
ILE A 264
SER A 268
None
1.21A 4c49A-2p9bA:
undetectable
4c49A-2p9bA:
22.46
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2qzu PUTATIVE SULFATASE
YIDJ


(Bacteroides
fragilis)
PF00884
(Sulfatase)
5 ALA A 205
SER A 206
THR A 306
PHE A 222
ASN A 213
None
1.23A 4c49A-2qzuA:
undetectable
4c49A-2qzuA:
21.24
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2r0b SERINE/THREONINE/TYR
OSINE-INTERACTING
PROTEIN


(Homo sapiens)
PF00782
(DSPc)
5 THR A 102
PHE A 130
ILE A  95
ASN A  94
PHE A  99
None
1.27A 4c49A-2r0bA:
undetectable
4c49A-2r0bA:
18.28
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2uxt PROTEIN SUFI

(Escherichia
coli)
PF00394
(Cu-oxidase)
PF07731
(Cu-oxidase_2)
PF07732
(Cu-oxidase_3)
5 ALA A 378
VAL A 376
PHE A 396
ILE A 356
PHE A 448
None
1.30A 4c49A-2uxtA:
undetectable
4c49A-2uxtA:
20.94
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2v95 CORTICOSTEROID-BINDI
NG GLOBULIN


(Rattus
norvegicus)
PF00079
(Serpin)
8 ALA A  13
VAL A  17
GLN A 224
THR A 232
PHE A 234
ILE A 255
PHE A 357
TRP A 362
HCY  A1375 (-3.6A)
HCY  A1375 ( 4.8A)
HCY  A1375 (-3.5A)
HCY  A1375 ( 4.2A)
HCY  A1375 (-4.8A)
None
HCY  A1375 ( 4.1A)
HCY  A1375 (-3.8A)
0.68A 4c49A-2v95A:
39.0
4c49A-2v95A:
61.39
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2v9k UNCHARACTERIZED
PROTEIN FLJ32312


(Homo sapiens)
no annotation 5 ALA A 416
SER A 415
THR A 497
ILE A 461
PHE A 489
None
1.15A 4c49A-2v9kA:
undetectable
4c49A-2v9kA:
20.52
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2w4k DEATH-ASSOCIATED
PROTEIN KINASE 1


(Homo sapiens)
PF00069
(Pkinase)
5 ALA A  25
SER A  21
VAL A  27
ILE A 160
ASN A 144
ADP  A1303 ( 3.7A)
None
ADP  A1303 (-4.0A)
ADP  A1303 ( 4.1A)
MG  A1304 ( 4.2A)
1.08A 4c49A-2w4kA:
undetectable
4c49A-2w4kA:
22.89
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2xax RIBONUCLEOSIDE-DIPHO
SPHATE REDUCTASE 1
SUBUNIT ALPHA


(Escherichia
coli)
PF00317
(Ribonuc_red_lgN)
PF02867
(Ribonuc_red_lgC)
PF03477
(ATP-cone)
5 THR A 276
PHE A 281
ILE A 237
ASN A 238
PHE A 274
None
1.23A 4c49A-2xaxA:
undetectable
4c49A-2xaxA:
19.73
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2yab DEATH-ASSOCIATED
PROTEIN KINASE 2


(Mus musculus)
PF00069
(Pkinase)
5 ALA A  25
SER A  21
VAL A  27
ILE A 160
ASN A 144
AMP  A1302 (-3.6A)
None
AMP  A1302 (-4.2A)
AMP  A1302 (-4.0A)
AMP  A1302 ( 4.8A)
1.12A 4c49A-2yabA:
undetectable
4c49A-2yabA:
21.30
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2yky BETA-TRANSAMINASE

(Mesorhizobium
sp. LUK)
PF00202
(Aminotran_3)
5 SER A 287
GLN A 331
THR A 330
ILE A 101
HIS A 326
None
1.02A 4c49A-2ykyA:
undetectable
4c49A-2ykyA:
22.64
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3dgz THIOREDOXIN
REDUCTASE 2


(Mus musculus)
PF02852
(Pyr_redox_dim)
PF07992
(Pyr_redox_2)
5 ALA A 452
SER A 453
VAL A 457
THR A 441
PHE A 444
None
1.28A 4c49A-3dgzA:
undetectable
4c49A-3dgzA:
22.31
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3dhu ALPHA-AMYLASE

(Lactobacillus
plantarum)
PF00128
(Alpha-amylase)
5 VAL A 165
PHE A  28
ILE A  51
ASN A  52
PHE A  85
None
1.22A 4c49A-3dhuA:
undetectable
4c49A-3dhuA:
24.72
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3dui BETA-GALACTOSIDE-BIN
DING LECTIN


(Gallus gallus)
PF00337
(Gal-bind_lectin)
5 SER A 107
VAL A  99
ILE A  59
PHE A  46
HIS A  45
None
1.08A 4c49A-3duiA:
undetectable
4c49A-3duiA:
17.20
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3f11 IRON TRANSPORT
PROTEIN


(Synechocystis
sp. PCC 6803)
PF13343
(SBP_bac_6)
5 ALA A 286
VAL A  98
PHE A 140
ILE A 296
SER A 121
None
1.30A 4c49A-3f11A:
undetectable
4c49A-3f11A:
21.18
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3f9r PHOSPHOMANNOMUTASE

(Trypanosoma
brucei)
PF03332
(PMM)
5 VAL A 239
THR A  42
PHE A  63
ILE A  30
PHE A   9
None
1.16A 4c49A-3f9rA:
undetectable
4c49A-3f9rA:
20.05
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3hj7 TRNA(ILE)-LYSIDINE
SYNTHASE


(Geobacillus
kaustophilus)
PF11734
(TilS_C)
5 ALA A 429
VAL A 380
PHE A 359
ILE A 455
SER A 357
None
1.31A 4c49A-3hj7A:
undetectable
4c49A-3hj7A:
16.62
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ibg ATPASE, SUBUNIT OF
THE GET COMPLEX


(Aspergillus
fumigatus)
PF02374
(ArsA_ATPase)
5 ALA A  91
SER A  90
VAL A  83
THR A  41
ILE A  48
None
None
None
ADP  A 349 (-3.6A)
None
1.26A 4c49A-3ibgA:
undetectable
4c49A-3ibgA:
22.66
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3isr TRANSGLUTAMINASE-LIK
E ENZYMES, PUTATIVE
CYSTEINE PROTEASE


(Cytophaga
hutchinsonii)
PF01841
(Transglut_core)
5 ALA A 242
ILE A   9
SER A   7
PHE A  21
HIS A  24
None
1.28A 4c49A-3isrA:
undetectable
4c49A-3isrA:
20.93
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3llr DNA
(CYTOSINE-5)-METHYLT
RANSFERASE 3A


(Homo sapiens)
PF00855
(PWWP)
6 ALA A 102
SER A 103
PHE A  80
ILE A 133
ASN A 129
PHE A  76
None
1.49A 4c49A-3llrA:
undetectable
4c49A-3llrA:
18.43
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3lm6 STAGE V SPORULATION
PROTEIN AD


(Bacillus
subtilis)
PF07451
(SpoVAD)
5 ALA A 283
SER A 282
VAL A 285
THR A  40
PHE A  37
None
1.11A 4c49A-3lm6A:
undetectable
4c49A-3lm6A:
22.47
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3lrh ANTI-HUNTINGTIN VL
DOMAIN


(Homo sapiens)
PF07686
(V-set)
5 ALA A  12
SER A  11
VAL A 107
ILE A  20
SER A  73
None
1.25A 4c49A-3lrhA:
undetectable
4c49A-3lrhA:
15.24
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3lw2 PLASMINOGEN
ACTIVATOR INHIBITOR
1


(Mus musculus)
PF00079
(Serpin)
5 ALA A 335
SER A 336
VAL A 324
ASN A 167
SER A  40
None
1.07A 4c49A-3lw2A:
43.0
4c49A-3lw2A:
28.57
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ml6 CHIMERIC COMPLEX
BETWEEN PROTEIN
DISHEVLLED2 HOMOLOG
DVL-2 AND CLATHRIN
ADAPTOR AP-2 COMPLEX
SUBUNIT MU


(Mus musculus;
Rattus
norvegicus)
PF00610
(DEP)
PF00928
(Adap_comp_sub)
5 ALA A1368
SER A1367
VAL A1303
ILE A1386
SER A1387
None
1.27A 4c49A-3ml6A:
undetectable
4c49A-3ml6A:
21.90
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3olz GLUTAMATE RECEPTOR,
IONOTROPIC KAINATE 3


(Rattus
norvegicus)
PF01094
(ANF_receptor)
5 ALA A 144
VAL A 146
THR A 249
PHE A 251
ILE A 132
None
1.14A 4c49A-3olzA:
undetectable
4c49A-3olzA:
22.17
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3oov METHYL-ACCEPTING
CHEMOTAXIS PROTEIN,
PUTATIVE


(Geobacter
sulfurreducens)
PF13185
(GAF_2)
5 SER A  47
VAL A  62
THR A  54
ILE A 104
PHE A  57
None
1.31A 4c49A-3oovA:
undetectable
4c49A-3oovA:
20.05
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3poy NEUREXIN-1-ALPHA

(Bos taurus)
PF00008
(EGF)
PF02210
(Laminin_G_2)
5 SER A 528
VAL A 601
THR A 533
ILE A 540
PHE A 531
None
1.28A 4c49A-3poyA:
undetectable
4c49A-3poyA:
18.38
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3pr2 TRYPTOPHAN SYNTHASE
BETA CHAIN


(Salmonella
enterica)
PF00291
(PALP)
5 ALA B 335
SER B 352
GLN B 370
THR B  71
ILE B 228
None
1.28A 4c49A-3pr2B:
undetectable
4c49A-3pr2B:
22.01
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3u97 RIBONUCLEASE TOXIN
BRNT


(Brucella
abortus)
PF04365
(BrnT_toxin)
5 SER A  70
VAL A  56
PHE A  26
ILE A   3
PHE A  29
None
1.31A 4c49A-3u97A:
undetectable
4c49A-3u97A:
13.79
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3wg1 GALACTOSIDE-BINDING
LECTIN


(Agrocybe
aegerita)
PF00337
(Gal-bind_lectin)
5 SER A  34
ILE A 147
ASN A  37
SER A  39
PHE A  96
None
1.20A 4c49A-3wg1A:
undetectable
4c49A-3wg1A:
18.97
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3zpx LIPASE

(Ustilago maydis)
PF03583
(LIP)
5 ALA A 236
SER A 239
VAL A 238
SER A 288
PHE A 222
None
1.28A 4c49A-3zpxA:
undetectable
4c49A-3zpxA:
22.13
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4aca TRANSLATION
ELONGATION FACTOR
SELB


(Methanococcus
maripaludis)
PF00009
(GTP_EFTU)
PF03144
(GTP_EFTU_D2)
5 ALA A  75
SER A  78
VAL A  77
ILE A 307
HIS A  69
None
1.22A 4c49A-4acaA:
undetectable
4c49A-4acaA:
21.04
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4axv MPAA

(Vibrio
campbellii)
PF04952
(AstE_AspA)
5 SER A  59
THR A 207
ILE A  43
PHE A 155
HIS A 156
None
None
None
None
ZN  A 301 (-3.2A)
1.31A 4c49A-4axvA:
undetectable
4c49A-4axvA:
21.41
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4b67 L-ORNITHINE N5
MONOOXYGENASE


(Aspergillus
fumigatus)
PF13434
(K_oxygenase)
5 SER A 417
VAL A 419
THR A 203
ILE A 451
PHE A 186
None
0.92A 4c49A-4b67A:
undetectable
4c49A-4b67A:
21.69
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4c41 CORTICOSTEROID-BINDI
NG GLOBULIN


(Homo sapiens)
PF00079
(Serpin)
5 ALA A  18
SER A  19
VAL A  22
GLN A 232
PHE A 366
None
0.74A 4c49A-4c41A:
58.9
4c49A-4c41A:
99.46
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4c41 CORTICOSTEROID-BINDI
NG GLOBULIN


(Homo sapiens)
PF00079
(Serpin)
7 ALA A  18
VAL A  22
GLN A 232
PHE A 242
ILE A 263
PHE A 366
HIS A 368
None
1.01A 4c49A-4c41A:
58.9
4c49A-4c41A:
99.46
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4c41 CORTICOSTEROID-BINDI
NG GLOBULIN


(Homo sapiens)
PF00079
(Serpin)
8 ALA A  18
VAL A  22
GLN A 232
THR A 240
PHE A 242
ILE A 263
ASN A 264
PHE A 366
None
0.70A 4c49A-4c41A:
58.9
4c49A-4c41A:
99.46
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4c41 CORTICOSTEROID-BINDI
NG GLOBULIN


(Homo sapiens)
PF00079
(Serpin)
5 GLN A 232
THR A 240
PHE A 242
ASN A 264
SER A 267
None
0.96A 4c49A-4c41A:
58.9
4c49A-4c41A:
99.46
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ccw CARBOXYL ESTERASE NP

(Bacillus
subtilis)
PF12697
(Abhydrolase_6)
5 ALA A 150
SER A 149
VAL A 147
PHE A 139
HIS A 135
None
1.25A 4c49A-4ccwA:
undetectable
4c49A-4ccwA:
20.91
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4cnt DIHYDROPYRIMIDINASE-
LIKE 3


(Homo sapiens)
PF01979
(Amidohydro_1)
5 SER A 385
GLN A 196
THR A 253
ILE A 391
HIS A  73
None
1.25A 4c49A-4cntA:
undetectable
4c49A-4cntA:
19.93
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4e93 TYROSINE-PROTEIN
KINASE FES/FPS


(Homo sapiens)
PF00017
(SH2)
PF07714
(Pkinase_Tyr)
5 SER A 494
VAL A 495
GLN A 535
THR A 533
HIS A 529
None
1.18A 4c49A-4e93A:
undetectable
4c49A-4e93A:
21.80
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4fq7 MALEATE CIS-TRANS
ISOMERASE


(Pseudomonas
putida)
no annotation 5 ALA A 223
SER A 222
VAL A 196
ILE A 125
HIS A  94
None
1.06A 4c49A-4fq7A:
undetectable
4c49A-4fq7A:
22.11
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4gaf EBI-005

(Homo sapiens)
PF00340
(IL1)
5 ALA A  58
SER A  44
PHE A 146
ILE A  10
PHE A 111
None
1.11A 4c49A-4gafA:
undetectable
4c49A-4gafA:
18.31
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4go4 PUTATIVE
GAMMA-HYDROXYMUCONIC
SEMIALDEHYDE
DEHYDROGENASE


(Pseudomonas sp.
WBC-3)
PF00171
(Aldedh)
5 ALA A 371
VAL A 369
ILE A 336
SER A 334
PHE A 386
None
1.29A 4c49A-4go4A:
undetectable
4c49A-4go4A:
22.16
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4lrs 4-HYDROXY-2-OXOVALER
ATE ALDOLASE


(Thermomonospora
curvata)
PF00682
(HMGL-like)
PF07836
(DmpG_comm)
5 ALA A 230
SER A  18
THR A 249
PHE A 250
ILE A 227
None
1.30A 4c49A-4lrsA:
undetectable
4c49A-4lrsA:
22.50
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ofw PROTEIN DJ-1 HOMOLOG
D


(Arabidopsis
thaliana)
PF01965
(DJ-1_PfpI)
5 ALA A 188
VAL A 186
ILE A  32
PHE A 388
HIS A 389
None
1.25A 4c49A-4ofwA:
undetectable
4c49A-4ofwA:
23.69
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4pfb C4-DICARBOXYLATE-BIN
DING PROTEIN


(Fusobacterium
nucleatum)
PF03480
(DctP)
5 VAL A  29
GLN A 251
ILE A  50
ASN A  51
SER A  54
None
1.21A 4c49A-4pfbA:
undetectable
4c49A-4pfbA:
20.15
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4pln NEOGENIN

(Mus musculus)
PF00041
(fn3)
5 ALA C 925
VAL C 908
GLN C 876
ILE C 887
SER C 878
None
1.22A 4c49A-4plnC:
undetectable
4c49A-4plnC:
18.88
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4qyr AT-LESS POLYKETIDE
SYNTHASE


(Streptomyces
platensis)
PF00109
(ketoacyl-synt)
PF02801
(Ketoacyl-synt_C)
PF16197
(KAsynt_C_assoc)
5 ALA A2779
GLN A2568
THR A2564
ILE A2889
PHE A2565
None
1.25A 4c49A-4qyrA:
undetectable
4c49A-4qyrA:
21.30
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4xvx ACYL-[ACYL-CARRIER-P
ROTEIN]
DEHYDROGENASE MBTN


(Mycobacterium
tuberculosis)
PF00441
(Acyl-CoA_dh_1)
PF02770
(Acyl-CoA_dh_M)
PF02771
(Acyl-CoA_dh_N)
5 ALA A  17
VAL A  22
PHE A  35
ILE A  79
HIS A  86
None
1.30A 4c49A-4xvxA:
undetectable
4c49A-4xvxA:
23.69
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4z61 PHYTOSULFOKINE
RECEPTOR 1


(Daucus carota)
PF00560
(LRR_1)
PF13855
(LRR_8)
5 ALA A 127
SER A 129
ILE A 154
SER A 176
PHE A 150
None
1.22A 4c49A-4z61A:
undetectable
4c49A-4z61A:
21.76
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4zo6 LIN1840 PROTEIN

(Listeria
innocua)
PF00933
(Glyco_hydro_3)
PF01915
(Glyco_hydro_3_C)
PF14310
(Fn3-like)
5 ALA A 188
VAL A 133
ILE A 268
PHE A 135
HIS A 192
None
None
None
BGC  A 802 (-4.3A)
BGC  A 802 (-4.0A)
1.16A 4c49A-4zo6A:
undetectable
4c49A-4zo6A:
19.92
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4zoy SQT1

(Chaetomium
thermophilum)
PF00400
(WD40)
5 ALA A 420
SER A 401
VAL A 426
GLN A 512
PHE A 510
None
1.26A 4c49A-4zoyA:
undetectable
4c49A-4zoyA:
22.07
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5aul PHOSPHATIDYLINOSITOL
3-KINASE REGULATORY
SUBUNIT ALPHA


(Homo sapiens)
PF00017
(SH2)
5 SER A 660
VAL A 661
GLN A 705
THR A 701
HIS A 697
None
1.21A 4c49A-5aulA:
undetectable
4c49A-5aulA:
17.89
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5b5z PTLCIB4 H88A MUTANT

(Phaeodactylum
tricornutum)
no annotation 5 ALA A  23
SER A  26
VAL A  25
GLN A 232
ILE A  98
None
1.24A 4c49A-5b5zA:
undetectable
4c49A-5b5zA:
21.09
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5c6w PROTEIN
IGHV1-69-2,IG LAMBDA
CHAIN V-II REGION
NIG-84


(Homo sapiens)
PF07686
(V-set)
5 ALA H1012
SER H1011
VAL H1107
ILE H1020
SER H1074
None
1.07A 4c49A-5c6wH:
undetectable
4c49A-5c6wH:
20.86
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5d04 PHOSPHO-2-DEHYDRO-3-
DEOXYHEPTONATE
ALDOLASE


(Neisseria
meningitidis)
PF00793
(DAHP_synth_1)
5 ALA C 251
VAL C 248
ILE C 266
ASN C 272
HIS C 232
None
1.29A 4c49A-5d04C:
undetectable
4c49A-5d04C:
24.04
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5eqv BIFUNCTIONAL
2',3'-CYCLIC
NUCLEOTIDE
2'-PHOSPHODIESTERASE
/3'-NUCLEOTIDASE
PERIPLASMIC
PRECURSOR PROTEIN


(Yersinia pestis)
PF00149
(Metallophos)
5 VAL A 150
ILE A 122
ASN A 121
PHE A 127
HIS A 125
None
None
None
None
PO4  A 405 ( 3.9A)
1.20A 4c49A-5eqvA:
undetectable
4c49A-5eqvA:
23.06
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5erd DESMOGLEIN-2

(Homo sapiens)
PF00028
(Cadherin)
5 SER A 148
GLN A 112
PHE A 115
ILE A 132
PHE A 110
None
1.18A 4c49A-5erdA:
undetectable
4c49A-5erdA:
21.07
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5fse UREASE SUBUNIT ALPHA

(Sporosarcina
pasteurii)
PF00449
(Urease_alpha)
PF01979
(Amidohydro_1)
5 SER C 496
THR C 136
ILE C 420
PHE C 158
HIS C 272
None
1.26A 4c49A-5fseC:
undetectable
4c49A-5fseC:
19.87
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5idu ACYL-COA
DEHYDROGENASE DOMAIN
PROTEIN


(Paraburkholderia
phymatum)
PF00441
(Acyl-CoA_dh_1)
PF02770
(Acyl-CoA_dh_M)
PF02771
(Acyl-CoA_dh_N)
5 SER A 127
VAL A 126
GLN A 233
ILE A 110
PHE A 177
None
1.30A 4c49A-5iduA:
undetectable
4c49A-5iduA:
20.09
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5j0g OXIDOREDUCTASE,SUPER
OXIDE DISMUTASE
[CU-ZN]


(Homo sapiens)
PF00080
(Sod_Cu)
5 ALA A  83
SER A  52
VAL A  85
PHE A  63
HIS A 108
None
1.31A 4c49A-5j0gA:
undetectable
4c49A-5j0gA:
16.58
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5j5j DESMOCOLLIN-2,DESMOG
LEIN-2


(Homo sapiens)
PF00028
(Cadherin)
5 SER A 146
GLN A 110
PHE A 113
ILE A 130
PHE A 108
None
1.18A 4c49A-5j5jA:
undetectable
4c49A-5j5jA:
19.89
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5j72 PUTATIVE
N-ACETYLMURAMOYL-L-A
LANINE
AMIDASE,AUTOLYSIN
CWP6


(Clostridioides
difficile)
PF01520
(Amidase_3)
PF04122
(CW_binding_2)
5 VAL A 424
THR A 403
ILE A 436
ASN A 437
SER A 434
None
1.13A 4c49A-5j72A:
undetectable
4c49A-5j72A:
20.97
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5lox PEPTIDASE

(Pseudomonas
aeruginosa)
no annotation 5 ALA A  15
SER A  16
ILE A 180
SER A 178
PHE A 215
None
1.25A 4c49A-5loxA:
undetectable
4c49A-5loxA:
19.59
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5oce PHOSPHATIDYLINOSITOL
MANNOSIDE
ACYLTRANSFERASE


(Mycolicibacterium
smegmatis)
no annotation 5 ALA A 199
PHE A 213
ILE A 276
ASN A 275
PHE A 212
None
1.29A 4c49A-5oceA:
undetectable
4c49A-5oceA:
13.03
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5u39 UDP-3-O-ACYL-N-ACETY
LGLUCOSAMINE
DEACETYLASE


(Pseudomonas
aeruginosa)
PF03331
(LpxC)
5 ALA A 172
SER A 173
VAL A 174
ILE A 243
HIS A 237
None
None
None
None
ZN  A 501 ( 3.2A)
1.07A 4c49A-5u39A:
undetectable
4c49A-5u39A:
22.48
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5vwm UDP-3-O-ACYL-N-ACETY
LGLUCOSAMINE
DEACETYLASE


(Pseudomonas
aeruginosa)
PF03331
(LpxC)
5 ALA A 172
SER A 173
VAL A 174
ILE A 243
HIS A 237
None
None
None
None
ZN  A 402 ( 3.3A)
1.08A 4c49A-5vwmA:
undetectable
4c49A-5vwmA:
24.57
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5wde KINESIN-LIKE PROTEIN
KIFC3


(Homo sapiens)
PF00225
(Kinesin)
5 SER A 746
VAL A 452
ILE A 479
SER A 489
PHE A 471
None
None
None
UNX  A 920 ( 4.4A)
None
1.12A 4c49A-5wdeA:
undetectable
4c49A-5wdeA:
22.11
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5xwz UNPLACED GENOMIC
SCAFFOLD
SUPERCONT1.36, WHOLE
GENOME SHOTGUN
SEQUENCE


(Cladophialophora
bantiana)
no annotation 5 ALA A 108
SER A 109
VAL A 111
THR A 260
ILE A 209
None
1.27A 4c49A-5xwzA:
undetectable
4c49A-5xwzA:
12.67