SIMILAR PATTERNS OF AMINO ACIDS FOR 4BZF_B_ACTB502_0

List of similar pattern of amino acids derived from ASSAM search

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click link on the last column to view superposed patterns of amino acids in NGL viewer)
(Note that only 3-12 residue patterns can be used for ASSAM searches)
Filter list by:
Hit Macromolecule/
Organism		 Pfam Res. Interface HETATM RMSD Dali Z-score Seq. Identity (%) View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1lur ALDOSE 1-EPIMERASE

(Caenorhabditis
elegans) 		PF01263
(Aldose_epim) 		4 HIS A1092
HIS A1163
ASP A1229
TYR A1270
 None
 0.24A 4bzfB-1lurA:
32.0		 4bzfB-1lurA:
25.07
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1snz ALDOSE 1-EPIMERASE

(Homo sapiens) 		PF01263
(Aldose_epim) 		4 HIS A 107
HIS A 176
ASP A 243
TYR A 281
 None
 0.41A 4bzfB-1snzA:
33.5		 4bzfB-1snzA:
26.11
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1yga HYPOTHETICAL 37.9
KDA PROTEIN IN
BIO3-HXT17
INTERGENIC REGION

(Saccharomyces
cerevisiae) 		PF01263
(Aldose_epim) 		4 HIS A  94
HIS A 176
ASP A 240
TYR A 289
 None
 0.38A 4bzfB-1ygaA:
32.4		 4bzfB-1ygaA:
24.47
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1z45 GAL10 BIFUNCTIONAL
PROTEIN

(Saccharomyces
cerevisiae) 		PF01263
(Aldose_epim)
PF16363
(GDP_Man_Dehyd) 		4 HIS A 458
HIS A 537
ASP A 599
TYR A 647
 GAL  A 700 (-4.1A)
GAL  A 700 (-4.1A)
GAL  A 700 (-2.8A)
GAL  A 700 (-4.1A)
 0.41A 4bzfB-1z45A:
32.9		 4bzfB-1z45A:
17.83
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2dqb DEOXYGUANOSINETRIPHO
SPHATE
TRIPHOSPHOHYDROLASE,
PUTATIVE

(Thermus
thermophilus) 		PF01966
(HD)
PF13286
(HD_assoc) 		4 HIS A 135
HIS A 117
ASP A 196
TYR A 200
 None
None
MG  A 506 (-2.4A)
MG  A 506 (-4.3A)
 1.43A 4bzfB-2dqbA:
undetectable		 4bzfB-2dqbA:
22.78
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3imh GALACTOSE-1-EPIMERAS
E

(Lactobacillus
acidophilus) 		PF01263
(Aldose_epim) 		4 HIS A 100
HIS A 173
ASP A 241
TYR A 274
 GOL  A 340 (-4.2A)
GOL  A 340 (-3.8A)
GOL  A 341 (-2.8A)
GOL  A 340 (-3.8A)
 0.57A 4bzfB-3imhA:
31.5		 4bzfB-3imhA:
22.25
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4bzg ALDOSE 1-EPIMERASE

(Bacillus
subtilis) 		PF01263
(Aldose_epim) 		4 HIS A 101
HIS A 177
ASP A 230
TYR A 271
 MAL  A 500 (-4.4A)
MAL  A 500 (-4.0A)
MAL  A 500 (-2.7A)
MAL  A 500 (-3.9A)
 0.16A 4bzfB-4bzgA:
56.7		 4bzfB-4bzgA:
100.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4rnl POSSIBLE GALACTOSE
MUTAROTASE

(Streptomyces
platensis) 		PF01263
(Aldose_epim) 		4 HIS A 110
HIS A 179
ASP A 239
TYR A 279
 GOL  A 401 (-4.2A)
GOL  A 401 (-3.9A)
GOL  A 401 (-2.8A)
GOL  A 401 ( 4.0A)
 0.31A 4bzfB-4rnlA:
33.6		 4bzfB-4rnlA:
22.99