SIMILAR PATTERNS OF AMINO ACIDS FOR 4BWL_C_MN9C1297

List of similar pattern of amino acids derived from ASSAM search

Hit pattern: 3D amino acid arrangements similar to known drug binding site

Query pattern: Residues from known binding site for annotated drug that match the hit pattern


(Click link on the last column to view superposed patterns of amino acids in NGL viewer)
(Note that only 3-12 residue patterns can be used for ASSAM searches)
Filter list by:
Hit Macromolecule/
Organism
Pfam Res. Interface HETATM RMSD Dali Z-score Seq. Identity (%) View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1crz TOLB PROTEIN

(Escherichia
coli)
PF04052
(TolB_N)
PF07676
(PD40)
5 ILE A  16
GLY A  13
GLY A  45
SER A  44
PHE A 142
None
1.20A 4bwlC-1crzA:
undetectable
4bwlC-1crzA:
23.43
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1gjv [3-METHYL-2-OXOBUTAN
OATE DEHYDROGENASE
[LIPOAMIDE]] KINASE


(Rattus
norvegicus)
PF02518
(HATPase_c)
PF10436
(BCDHK_Adom3)
5 ILE A 290
LEU A 295
THR A 364
GLY A 363
GLY A 361
AGS  A1383 ( 4.5A)
None
AGS  A1383 (-4.1A)
None
None
1.25A 4bwlC-1gjvA:
undetectable
4bwlC-1gjvA:
23.18
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1h67 CALPONIN ALPHA

(Gallus gallus)
PF00307
(CH)
5 ILE A  38
LEU A 124
ASP A  56
GLY A  57
PHE A 106
None
1.21A 4bwlC-1h67A:
undetectable
4bwlC-1h67A:
17.16
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1hl2 N-ACETYLNEURAMINATE
LYASE SUBUNIT


(Escherichia
coli)
PF00701
(DHDPS)
9 ILE A 139
THR A 167
GLY A 189
TYR A 190
ASP A 191
GLU A 192
GLY A 207
SER A 208
PHE A 252
3PY  A 802 ( 4.9A)
3PY  A 802 (-3.6A)
None
None
None
None
None
None
None
0.39A 4bwlC-1hl2A:
52.2
4bwlC-1hl2A:
97.04
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1kcx DIHYDROPYRIMIDINASE
RELATED PROTEIN-1


(Mus musculus)
PF01979
(Amidohydro_1)
5 LEU A 196
GLY A 332
ASP A  71
GLY A 330
PHE A 392
None
1.24A 4bwlC-1kcxA:
8.0
4bwlC-1kcxA:
19.47
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1kzh PHOSPHOFRUCTOKINASE

(Borreliella
burgdorferi)
PF00365
(PFK)
5 ILE A 173
LEU A  79
GLY A 447
GLY A  93
SER A  92
None
1.19A 4bwlC-1kzhA:
undetectable
4bwlC-1kzhA:
19.25
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1qo8 FLAVOCYTOCHROME C3
FUMARATE REDUCTASE


(Shewanella
frigidimarina)
PF00890
(FAD_binding_2)
PF14537
(Cytochrom_c3_2)
5 ILE A 299
LEU A 125
ASP A  27
GLY A 291
SER A 271
None
1.19A 4bwlC-1qo8A:
undetectable
4bwlC-1qo8A:
20.94
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1uas ALPHA-GALACTOSIDASE

(Oryza sativa)
PF16499
(Melibiase_2)
PF17450
(Melibiase_2_C)
5 ILE A 260
LEU A 261
ASP A 188
GLU A 219
GLY A 223
None
1.21A 4bwlC-1uasA:
9.4
4bwlC-1uasA:
20.63
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1urh 3-MERCAPTOPYRUVATE
SULFURTRANSFERASE


(Escherichia
coli)
PF00581
(Rhodanese)
5 LEU A 132
GLY A 121
TYR A  92
ASP A  93
GLY A  95
None
1.20A 4bwlC-1urhA:
undetectable
4bwlC-1urhA:
20.74
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1w0m TRIOSEPHOSPHATE
ISOMERASE


(Thermoproteus
tenax)
PF00121
(TIM)
PF05690
(ThiG)
5 ILE A 160
LEU A 194
THR A 178
GLY A 179
GLY A 181
None
None
None
None
PO4  A1226 (-3.6A)
0.97A 4bwlC-1w0mA:
13.0
4bwlC-1w0mA:
25.48
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2d2x 2-DEOXY-SCYLLO-INOSO
SE SYNTHASE


(Bacillus
circulans)
PF01761
(DHQ_synthase)
5 ILE A 241
LEU A 351
GLY A 342
GLY A 340
SER A 339
None
1.12A 4bwlC-2d2xA:
2.8
4bwlC-2d2xA:
23.59
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2e3z BETA-GLUCOSIDASE

(Phanerochaete
chrysosporium)
PF00232
(Glyco_hydro_1)
5 ILE A  34
GLY A 178
TYR A 179
GLU A 193
GLY A 182
None
1.20A 4bwlC-2e3zA:
10.1
4bwlC-2e3zA:
22.06
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2epg HYPOTHETICAL PROTEIN
TTHA1785


(Thermus
thermophilus)
PF01139
(RtcB)
5 LEU A 176
GLY A  99
ASP A  95
GLY A 237
SER A 238
None
1.09A 4bwlC-2epgA:
undetectable
4bwlC-2epgA:
20.28
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2exa PENICILLIN-BINDING
PROTEIN 4


(Escherichia
coli)
PF02113
(Peptidase_S13)
5 ILE A 131
LEU A 101
GLY A  95
GLY A 127
SER A 126
None
1.12A 4bwlC-2exaA:
undetectable
4bwlC-2exaA:
23.28
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2go4 UDP-3-O-[3-HYDROXYMY
RISTOYL]
N-ACETYLGLUCOSAMINE
DEACETYLASE


(Aquifex
aeolicus)
PF03331
(LpxC)
5 ILE A  80
GLY A 108
ASP A 105
GLU A 110
GLY A 106
None
1.17A 4bwlC-2go4A:
undetectable
4bwlC-2go4A:
21.19
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2hmf PROBABLE
ASPARTOKINASE


(Methanocaldococcus
jannaschii)
PF00696
(AA_kinase)
PF01842
(ACT)
PF13840
(ACT_7)
5 ILE A 350
LEU A 351
TYR A 262
GLY A 264
SER A 313
None
1.08A 4bwlC-2hmfA:
undetectable
4bwlC-2hmfA:
21.63
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2nwq PROBABLE SHORT-CHAIN
DEHYDROGENASE


(Pseudomonas
aeruginosa)
PF00106
(adh_short)
5 ILE A 126
LEU A 122
THR A 173
GLY A 174
GLY A 131
None
1.26A 4bwlC-2nwqA:
2.4
4bwlC-2nwqA:
24.93
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2o9r BETA-GLUCOSIDASE B

(Paenibacillus
polymyxa)
PF00232
(Glyco_hydro_1)
5 ILE A  36
GLY A 175
TYR A 176
GLU A 190
GLY A 179
None
1.20A 4bwlC-2o9rA:
10.5
4bwlC-2o9rA:
22.88
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2pge MENC

(Desulfotalea
psychrophila)
PF13378
(MR_MLE_C)
5 ILE A  39
LEU A  81
GLY A  43
ASP A 131
GLY A 135
None
1.21A 4bwlC-2pgeA:
5.7
4bwlC-2pgeA:
22.05
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2q0f RNA URIDYLYL
TRANSFERASE


(Trypanosoma
brucei)
PF03828
(PAP_assoc)
5 LEU A 321
THR A 175
GLY A 176
GLY A 184
SER A 185
None
1.22A 4bwlC-2q0fA:
undetectable
4bwlC-2q0fA:
23.06
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2reb REC A

(Escherichia
coli)
PF00154
(RecA)
5 ILE A  64
ASP A  48
GLY A  43
SER A  44
PHE A 260
None
1.13A 4bwlC-2rebA:
undetectable
4bwlC-2rebA:
24.42
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2x24 ACETYL-COA
CARBOXYLASE


(Bos taurus)
PF01039
(Carboxyl_trans)
5 LEU A 270
TYR A 135
ASP A 132
GLY A 235
SER A 236
None
1.18A 4bwlC-2x24A:
undetectable
4bwlC-2x24A:
18.24
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2ymb MIT
DOMAIN-CONTAINING
PROTEIN 1


(Homo sapiens)
PF16565
(MIT_C)
5 ILE A  94
THR A 236
GLY A 208
GLY A 210
PHE A 107
None
1.27A 4bwlC-2ymbA:
undetectable
4bwlC-2ymbA:
22.86
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ahy BETA-GLUCOSIDASE

(Trichoderma
reesei)
PF00232
(Glyco_hydro_1)
5 ILE A  30
GLY A 173
TYR A 174
GLU A 188
GLY A 177
None
1.17A 4bwlC-3ahyA:
10.3
4bwlC-3ahyA:
23.85
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ber PROBABLE
ATP-DEPENDENT RNA
HELICASE DDX47


(Homo sapiens)
PF00270
(DEAD)
5 ILE A 108
LEU A 104
GLY A  76
GLY A  73
SER A  72
None
None
None
AMP  A 300 (-3.3A)
AMP  A 300 (-4.1A)
1.20A 4bwlC-3berA:
undetectable
4bwlC-3berA:
23.82
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3bl6 5'-METHYLTHIOADENOSI
NE
NUCLEOSIDASE/S-ADENO
SYLHOMOCYSTEINE
NUCLEOSIDASE


(Staphylococcus
aureus)
PF01048
(PNP_UDP_1)
5 GLY A   6
GLU A 173
GLY A  74
SER A  75
PHE A 206
None
FMC  A 229 (-2.5A)
None
FMC  A 229 (-3.0A)
FMC  A 229 (-4.6A)
0.81A 4bwlC-3bl6A:
undetectable
4bwlC-3bl6A:
20.97
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3bq9 PREDICTED ROSSMANN
FOLD
NUCLEOTIDE-BINDING
DOMAIN-CONTAINING
PROTEIN


(Idiomarina
baltica)
PF03641
(Lysine_decarbox)
PF11892
(DUF3412)
PF14793
(DUF4478)
5 ILE A 250
LEU A 282
GLY A 151
GLU A 159
GLY A 254
None
None
None
GOL  A 463 ( 4.9A)
SO4  A 460 (-3.5A)
1.19A 4bwlC-3bq9A:
undetectable
4bwlC-3bq9A:
22.53
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3bq9 PREDICTED ROSSMANN
FOLD
NUCLEOTIDE-BINDING
DOMAIN-CONTAINING
PROTEIN


(Idiomarina
baltica)
PF03641
(Lysine_decarbox)
PF11892
(DUF3412)
PF14793
(DUF4478)
5 ILE A 250
LEU A 282
GLY A 152
GLU A 159
GLY A 254
None
None
SO4  A 460 (-3.3A)
GOL  A 463 ( 4.9A)
SO4  A 460 (-3.5A)
1.20A 4bwlC-3bq9A:
undetectable
4bwlC-3bq9A:
22.53
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3c0i PERIPHERAL PLASMA
MEMBRANE PROTEIN
CASK


(Homo sapiens)
PF00069
(Pkinase)
5 ILE A 167
GLY A 197
TYR A 196
GLY A 173
SER A 172
None
1.00A 4bwlC-3c0iA:
undetectable
4bwlC-3c0iA:
20.59
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3cmt PROTEIN RECA

(Escherichia
coli)
PF00154
(RecA)
5 ILE A  64
ASP A  48
GLY A  43
SER A  44
PHE A 260
None
1.12A 4bwlC-3cmtA:
undetectable
4bwlC-3cmtA:
11.34
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3cmt PROTEIN RECA

(Escherichia
coli)
PF00154
(RecA)
5 ILE A1064
ASP A1048
GLY A1043
SER A1044
PHE A1260
None
1.13A 4bwlC-3cmtA:
undetectable
4bwlC-3cmtA:
11.34
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3cmt PROTEIN RECA

(Escherichia
coli)
PF00154
(RecA)
5 ILE A2064
ASP A2048
GLY A2043
SER A2044
PHE A2260
None
1.13A 4bwlC-3cmtA:
undetectable
4bwlC-3cmtA:
11.34
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3cmu PROTEIN RECA

(Escherichia
coli)
PF00154
(RecA)
5 ILE A  64
ASP A  48
GLY A  43
SER A  44
PHE A 260
None
1.10A 4bwlC-3cmuA:
undetectable
4bwlC-3cmuA:
10.07
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3cmu PROTEIN RECA

(Escherichia
coli)
PF00154
(RecA)
5 ILE A1064
ASP A1048
GLY A1043
SER A1044
PHE A1260
None
1.10A 4bwlC-3cmuA:
undetectable
4bwlC-3cmuA:
10.07
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3cmu PROTEIN RECA

(Escherichia
coli)
PF00154
(RecA)
5 ILE A4064
ASP A4048
GLY A4043
SER A4044
PHE A4260
None
1.10A 4bwlC-3cmuA:
undetectable
4bwlC-3cmuA:
10.07
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3cmu PROTEIN RECA

(Escherichia
coli)
PF00154
(RecA)
5 ILE A5064
ASP A5048
GLY A5043
SER A5044
PHE A5260
None
1.10A 4bwlC-3cmuA:
undetectable
4bwlC-3cmuA:
10.07
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3cmv PROTEIN RECA

(Escherichia
coli)
PF00154
(RecA)
5 ILE A2064
ASP A2048
GLY A2043
SER A2044
PHE A2260
None
1.14A 4bwlC-3cmvA:
undetectable
4bwlC-3cmvA:
12.73
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3cyv UROPORPHYRINOGEN
DECARBOXYLASE


(Shigella
flexneri)
PF01208
(URO-D)
5 ILE A 167
LEU A 178
THR A 153
ASP A 208
GLY A 211
None
1.23A 4bwlC-3cyvA:
6.4
4bwlC-3cyvA:
19.89
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3dm9 SIGNAL RECOGNITION
PARTICLE RECEPTOR


(Pyrococcus
furiosus)
PF00448
(SRP54)
PF02881
(SRP54_N)
5 ILE B 284
GLY B 248
ASP B 275
GLY B 278
PHE B 312
None
1.26A 4bwlC-3dm9B:
undetectable
4bwlC-3dm9B:
23.63
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3dp9 MTA/SAH NUCLEOSIDASE

(Vibrio cholerae)
PF01048
(PNP_UDP_1)
5 GLY A   7
GLU A 175
GLY A  75
SER A  76
PHE A 208
None
BIG  A 301 (-2.8A)
None
BIG  A 301 (-3.3A)
BIG  A 301 (-4.3A)
0.85A 4bwlC-3dp9A:
undetectable
4bwlC-3dp9A:
24.61
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3eei 5-METHYLTHIOADENOSIN
E
NUCLEOSIDASE/S-ADENO
SYLHOMOCYSTEINE
NUCLEOSIDASE


(Neisseria
meningitidis)
PF01048
(PNP_UDP_1)
5 GLY A  10
GLU A 178
GLY A  78
SER A  79
PHE A 211
None
MTM  A 234 (-2.6A)
None
MTM  A 234 (-3.1A)
MTM  A 234 (-4.4A)
0.86A 4bwlC-3eeiA:
undetectable
4bwlC-3eeiA:
21.45
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3fah ALDEHYDE
OXIDOREDUCTASE


(Desulfovibrio
gigas)
PF00111
(Fer2)
PF01315
(Ald_Xan_dh_C)
PF01799
(Fer2_2)
PF02738
(Ald_Xan_dh_C2)
5 ILE A 808
LEU A 791
GLY A 868
GLY A 866
SER A 865
None
None
PCD  A 921 (-3.5A)
PCD  A 921 (-3.4A)
PCD  A 921 (-4.9A)
1.24A 4bwlC-3fahA:
undetectable
4bwlC-3fahA:
16.50
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ff6 ACETYL-COA
CARBOXYLASE 2


(Homo sapiens)
PF01039
(Carboxyl_trans)
5 LEU A1945
TYR A1810
ASP A1807
GLY A1910
SER A1911
None
1.25A 4bwlC-3ff6A:
undetectable
4bwlC-3ff6A:
17.11
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3hul HOMOSERINE KINASE

(Listeria
monocytogenes)
PF00288
(GHMP_kinases_N)
PF08544
(GHMP_kinases_C)
5 ILE A 159
THR A 248
GLY A  83
GLY A  85
SER A  86
None
None
SO4  A 297 (-3.4A)
SO4  A 297 (-3.3A)
SO4  A 297 (-4.6A)
1.09A 4bwlC-3hulA:
undetectable
4bwlC-3hulA:
24.77
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3i8b XYLULOSE KINASE

(Bifidobacterium
adolescentis)
PF00370
(FGGY_N)
PF02782
(FGGY_C)
5 ILE A 290
LEU A 429
GLY A 296
GLY A 332
SER A 333
None
0.90A 4bwlC-3i8bA:
undetectable
4bwlC-3i8bA:
20.49
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3jz4 SUCCINATE-SEMIALDEHY
DE DEHYDROGENASE
[NADP+]


(Escherichia
coli)
PF00171
(Aldedh)
5 ILE A 436
LEU A 413
GLY A 438
GLY A 442
SER A 279
None
1.14A 4bwlC-3jz4A:
undetectable
4bwlC-3jz4A:
22.66
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3nvl 2,3-BISPHOSPHOGLYCER
ATE-INDEPENDENT
PHOSPHOGLYCERATE
MUTASE


(Trypanosoma
brucei)
PF01676
(Metalloenzyme)
PF06415
(iPGM_N)
5 ILE A 195
LEU A 179
GLY A 198
TYR A 162
PHE A 278
None
1.17A 4bwlC-3nvlA:
undetectable
4bwlC-3nvlA:
20.79
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3o4v MTA/SAH NUCLEOSIDASE

(Escherichia
coli)
PF01048
(PNP_UDP_1)
5 GLY A   7
GLU A 174
GLY A  75
SER A  76
PHE A 207
None
4CT  A 233 (-3.0A)
None
4CT  A 233 (-3.2A)
4CT  A 233 (-4.5A)
0.81A 4bwlC-3o4vA:
undetectable
4bwlC-3o4vA:
23.42
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3pqv RCL1 PROTEIN

(Kluyveromyces
lactis)
PF01137
(RTC)
PF05189
(RTC_insert)
5 ILE A  80
LEU A 105
GLY A  61
SER A  62
PHE A  75
None
0.98A 4bwlC-3pqvA:
undetectable
4bwlC-3pqvA:
23.99
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3qre ENOYL-COA HYDRATASE,
ECHA12_1


(Mycobacterium
marinum)
PF00378
(ECH_1)
5 ILE A 157
LEU A 161
THR A 126
GLY A 124
PHE A 180
None
1.23A 4bwlC-3qreA:
undetectable
4bwlC-3qreA:
23.51
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3s5r TRANSCRIPTIONAL
REGULATOR TETR
FAMILY


(Syntrophus
aciditrophicus)
PF00440
(TetR_N)
5 ILE A  94
THR A 165
GLY A 163
GLY A 159
PHE A 135
None
1.13A 4bwlC-3s5rA:
undetectable
4bwlC-3s5rA:
21.24
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3v44 TOLL-LIKE RECEPTOR
5B AND VARIABLE
LYMPHOCYTE RECEPTOR
B.61 CHIMERIC
PROTEIN


(Eptatretus
burgeri;
Danio rerio)
PF11921
(DUF3439)
PF13855
(LRR_8)
5 ILE A 258
LEU A 234
THR A 256
GLY A 255
GLY A 288
None
1.15A 4bwlC-3v44A:
undetectable
4bwlC-3v44A:
19.32
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3vc7 PUTATIVE
OXIDOREDUCTASE


(Sinorhizobium
meliloti)
PF13561
(adh_short_C2)
5 ILE A  11
LEU A 123
GLY A  14
GLY A  38
SER A  60
None
1.28A 4bwlC-3vc7A:
undetectable
4bwlC-3vc7A:
22.04
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3zbq PHIKZ039

(Pseudomonas
virus phiKZ)
no annotation 5 ILE A  81
LEU A  80
THR A 111
GLY A 109
GLY A  13
None
None
None
GDP  A 999 (-3.5A)
GDP  A 999 (-3.6A)
1.27A 4bwlC-3zbqA:
undetectable
4bwlC-3zbqA:
19.02
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4b6j PHOSPHOSERINE
PHOSPHATASE


(Thermococcus
onnurineus)
PF12710
(HAD)
5 ILE A   7
THR A  12
GLY A  11
GLY A 152
PHE A 159
None
1.19A 4bwlC-4b6jA:
undetectable
4bwlC-4b6jA:
21.38
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4brz HALOALKANE
DEHALOGENASE


(Rhodobacteraceae)
PF00561
(Abhydrolase_1)
5 ILE A  30
LEU A  50
THR A 101
GLY A 125
SER A 291
None
1.01A 4bwlC-4brzA:
undetectable
4bwlC-4brzA:
23.01
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4cu8 GLYCOSIDE HYDROLASE
2


(Streptococcus
pneumoniae)
PF00703
(Glyco_hydro_2)
PF02836
(Glyco_hydro_2_C)
PF02837
(Glyco_hydro_2_N)
PF16355
(DUF4982)
5 ILE A 565
GLY A 512
TYR A 511
GLU A 524
GLY A 520
None
1.26A 4bwlC-4cu8A:
10.9
4bwlC-4cu8A:
16.49
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4dao PURINE NUCLEOSIDE
PHOSPHORYLASE
DEOD-TYPE


(Bacillus
subtilis)
PF01048
(PNP_UDP_1)
5 ILE A  69
LEU A 184
THR A  62
GLY A  20
GLY A  89
None
1.22A 4bwlC-4daoA:
undetectable
4bwlC-4daoA:
24.48
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ei8 PLASMID REPLICATION
PROTEIN REPX


(Bacillus cereus)
PF00091
(Tubulin)
5 ILE A 183
LEU A 282
THR A 149
GLY A 120
GLY A  27
None
1.27A 4bwlC-4ei8A:
2.8
4bwlC-4ei8A:
22.75
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4fdw LEUCINE RICH
HYPOTHETICAL PROTEIN


(Bacteroides
ovatus)
PF07523
(Big_3)
PF13306
(LRR_5)
5 ILE A 219
LEU A 198
THR A 217
ASP A 213
PHE A 227
None
1.00A 4bwlC-4fdwA:
undetectable
4bwlC-4fdwA:
23.36
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4i0w PROTEASE CSPB

(Clostridium
perfringens)
PF00082
(Peptidase_S8)
5 ILE B 215
THR B 216
ASP B 179
GLU B 177
GLY B 184
None
1.26A 4bwlC-4i0wB:
undetectable
4bwlC-4i0wB:
21.22
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4imd N-ACETYLNEURAMINATE
LYASE


(Pasteurella
multocida)
PF00701
(DHDPS)
8 ILE A 138
LEU A 141
THR A 166
GLY A 188
ASP A 190
GLU A 191
GLY A 206
SER A 207
None
None
None
KPI  A 164 ( 4.4A)
EDO  A 303 (-3.4A)
EDO  A 303 (-3.4A)
KPI  A 164 ( 4.2A)
EDO  A 303 ( 4.0A)
0.50A 4bwlC-4imdA:
42.2
4bwlC-4imdA:
36.27
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4k91 D-ALA-D-ALA-CARBOXYP
EPTIDASE


(Pseudomonas
aeruginosa)
PF00768
(Peptidase_S11)
PF07943
(PBP5_C)
5 ILE A  97
THR A  47
ASP A 140
GLU A 117
GLY A 143
None
0.99A 4bwlC-4k91A:
undetectable
4bwlC-4k91A:
23.94
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4le4 BETA-GLUCANASE

(Podospora
anserina)
no annotation 5 ILE A  21
GLY A 260
ASP A  73
GLY A  75
SER A  76
None
0.81A 4bwlC-4le4A:
undetectable
4bwlC-4le4A:
20.26
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4mca GLYCEROL
DEHYDROGENASE


(Serratia
plymuthica)
PF00465
(Fe-ADH)
5 LEU A 127
GLY A 249
GLU A 178
GLY A 244
SER A 241
None
None
None
None
NA  A1004 (-3.4A)
1.27A 4bwlC-4mcaA:
3.2
4bwlC-4mcaA:
23.10
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4mdp BETA-GLUCOSIDASE

(Humicola grisea)
PF00232
(Glyco_hydro_1)
5 ILE A  31
GLY A 174
TYR A 175
GLU A 199
SER A 191
None
1.17A 4bwlC-4mdpA:
10.5
4bwlC-4mdpA:
21.78
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4mwt LYSOSOMAL PROTECTIVE
PROTEIN


(Homo sapiens)
PF00450
(Peptidase_S10)
5 LEU A 174
GLY A 177
ASP A 380
GLY A 179
SER A 181
LEU  A 174 ( 0.5A)
GLY  A 177 ( 0.0A)
ASP  A 380 ( 0.5A)
GLY  A 179 ( 0.0A)
SER  A 181 ( 0.0A)
1.13A 4bwlC-4mwtA:
undetectable
4bwlC-4mwtA:
20.89
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4n81 INOSITOL
MONOPHOSPHATASE


(Zymomonas
mobilis)
PF00459
(Inositol_P)
5 ILE A 142
LEU A 195
THR A 135
GLY A 220
GLY A 223
None
1.28A 4bwlC-4n81A:
undetectable
4bwlC-4n81A:
22.36
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4npa PUTATIVE
UNCHARACTERIZED
PROTEIN


(Vibrio cholerae)
PF03641
(Lysine_decarbox)
PF11892
(DUF3412)
PF14793
(DUF4478)
5 ILE A 256
LEU A 288
GLY A 157
GLU A 165
GLY A 260
None
None
None
None
SO4  A 501 (-3.4A)
1.22A 4bwlC-4npaA:
undetectable
4bwlC-4npaA:
20.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4npa PUTATIVE
UNCHARACTERIZED
PROTEIN


(Vibrio cholerae)
PF03641
(Lysine_decarbox)
PF11892
(DUF3412)
PF14793
(DUF4478)
5 ILE A 256
LEU A 288
GLY A 158
GLU A 165
GLY A 260
None
None
SO4  A 501 (-3.6A)
None
SO4  A 501 (-3.4A)
1.21A 4bwlC-4npaA:
undetectable
4bwlC-4npaA:
20.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4oue PUTATIVE LIPOPROTEIN

(Bacteroides
thetaiotaomicron)
PF00754
(F5_F8_type_C)
PF01120
(Alpha_L_fucos)
5 LEU A 175
GLY A 147
TYR A 168
ASP A 150
GLY A 102
None
1.25A 4bwlC-4oueA:
7.4
4bwlC-4oueA:
22.39
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4qez 5'-METHYLTHIOADENOSI
NE/S-ADENOSYLHOMOCYS
TEINE NUCLEOSIDASE


(Bacillus
anthracis)
no annotation 5 GLY B   7
GLU B 175
GLY B  75
SER B  76
PHE B 208
None
TRS  B 302 (-2.7A)
TRS  B 302 ( 4.6A)
TRS  B 302 (-2.8A)
TRS  B 302 ( 4.7A)
0.84A 4bwlC-4qezB:
undetectable
4bwlC-4qezB:
22.98
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4re2 BETA-MANNOSIDASE/BET
A-GLUCOSIDASE


(Oryza sativa)
PF00232
(Glyco_hydro_1)
5 ILE A  46
GLY A 187
TYR A 188
GLU A 210
GLY A 191
None
1.25A 4bwlC-4re2A:
10.9
4bwlC-4re2A:
19.34
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4tym PURINE NUCLEOSIDE
PHOSPHORYLASE
DEOD-TYPE


(Streptococcus
agalactiae)
PF01048
(PNP_UDP_1)
5 ILE A  91
LEU A 207
THR A  84
GLY A  42
GLY A 111
None
None
None
SO4  A 301 (-3.3A)
SO4  A 301 (-3.6A)
1.09A 4bwlC-4tymA:
undetectable
4bwlC-4tymA:
24.77
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4u48 PUTATIVE INNER
MEMBRANE LIPOPROTEIN


(Salmonella
enterica)
PF00207
(A2M)
PF01835
(A2M_N)
PF07703
(A2M_N_2)
PF10569
(Thiol-ester_cl)
PF11974
(MG1)
5 ILE A 251
LEU A 254
THR A 229
GLY A 230
PHE A 279
None
1.25A 4bwlC-4u48A:
undetectable
4bwlC-4u48A:
11.60
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4uhq LARGE COMPONENT OF
PYOCIN AP41


(Pseudomonas
aeruginosa)
no annotation 5 ILE A 674
GLY A 651
ASP A 753
GLY A 649
PHE A 689
None
1.09A 4bwlC-4uhqA:
undetectable
4bwlC-4uhqA:
19.16
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4woq N-ACETYLNEURAMINATE
LYASE


(Clostridioides
difficile)
PF00701
(DHDPS)
8 ILE A 149
LEU A 152
THR A 177
GLY A 199
ASP A 201
GLU A 202
GLY A 217
SER A 218
None
0.39A 4bwlC-4woqA:
42.9
4bwlC-4woqA:
35.06
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4yhs MONOSACCHARIDE ABC
TRANSPORTER
SUBSTRATE-BINDING
PROTEIN, CUT2 FAMILY


(Bradyrhizobium
sp. BTAi1)
PF13407
(Peripla_BP_4)
5 ILE A 124
LEU A 101
GLY A 122
ASP A 145
GLY A 149
None
1.04A 4bwlC-4yhsA:
undetectable
4bwlC-4yhsA:
25.19
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4yit MEGANUCLEASE I-AABMI

(Gremmeniella
abietina)
PF00961
(LAGLIDADG_1)
5 ILE A 156
GLY A   8
GLY A 164
SER A 163
PHE A 239
None
1.28A 4bwlC-4yitA:
undetectable
4bwlC-4yitA:
23.78
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4z8z UNCHARACTERIZED
PROTEIN


(Ruminiclostridium
thermocellum)
no annotation 5 ILE A 264
LEU A 292
THR A 206
GLY A 190
PHE A 283
None
1.24A 4bwlC-4z8zA:
undetectable
4bwlC-4z8zA:
20.78
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5afd N-ACETYLNEURAMINATE
LYASE


(Aliivibrio
salmonicida)
PF00701
(DHDPS)
5 GLY A 191
ASP A 193
GLU A 194
GLY A 209
SER A 210
None
EDO  A1304 (-3.7A)
EDO  A1304 (-3.0A)
None
EDO  A1304 ( 3.9A)
0.32A 4bwlC-5afdA:
38.2
4bwlC-5afdA:
27.33
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5dk6 5'-METHYLTHIOADENOSI
NE/S-ADENOSYLHOMOCYS
TEINE NUCLEOSIDASE


(Colwellia
psychrerythraea)
PF01048
(PNP_UDP_1)
5 GLY A   7
GLU A 180
GLY A  75
SER A  76
PHE A 213
None
None
None
ADE  A 302 ( 3.7A)
GLY  A 301 ( 4.7A)
0.84A 4bwlC-5dk6A:
undetectable
4bwlC-5dk6A:
23.87
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5dx5 METHIONINE
GAMMA-LYASE


(Clostridium
sporogenes)
PF01053
(Cys_Met_Meta_PP)
5 ILE A 398
LEU A 395
GLY A 321
GLU A 288
GLY A 373
None
1.28A 4bwlC-5dx5A:
undetectable
4bwlC-5dx5A:
22.14
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5epg ALDEHYDE OXIDASE

(Homo sapiens)
PF00111
(Fer2)
PF00941
(FAD_binding_5)
PF01315
(Ald_Xan_dh_C)
PF01799
(Fer2_2)
PF02738
(Ald_Xan_dh_C2)
PF03450
(CO_deh_flav_C)
5 ILE A 291
LEU A 249
GLY A 309
GLY A 307
SER A 413
None
1.20A 4bwlC-5epgA:
undetectable
4bwlC-5epgA:
13.96
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5f1y MCCC FAMILY PROTEIN

(Bacillus cereus)
PF02016
(Peptidase_S66)
5 ILE A  88
ASP A  26
GLU A  28
GLY A  57
SER A  58
None
1.17A 4bwlC-5f1yA:
undetectable
4bwlC-5f1yA:
20.94
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5fi5 TETRAHYDROALSTONINE
SYNTHASE


(Catharanthus
roseus)
PF00107
(ADH_zinc_N)
PF08240
(ADH_N)
5 ILE A 349
LEU A 353
GLY A  52
ASP A  57
GLY A  75
None
1.18A 4bwlC-5fi5A:
undetectable
4bwlC-5fi5A:
23.42
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5g06 EXOSOME COMPLEX
COMPONENT SKI6
EXOSOME COMPLEX
COMPONENT RRP4


(Saccharomyces
cerevisiae;
Saccharomyces
cerevisiae)
PF01138
(RNase_PH)
PF03725
(RNase_PH_C)
PF14382
(ECR1_N)
PF15985
(KH_6)
5 GLY H  58
TYR H  81
ASP B 156
GLY B 191
SER B 193
None
1.27A 4bwlC-5g06H:
undetectable
4bwlC-5g06H:
20.41
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5gnx BETA-GLUCOSIDASE

(metagenome)
PF00232
(Glyco_hydro_1)
5 ILE A  39
GLY A 179
TYR A 180
GLU A 194
GLY A 183
None
1.24A 4bwlC-5gnxA:
10.9
4bwlC-5gnxA:
22.49
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5h82 HETEROYOHIMBINE
SYNTHASE THAS2


(Catharanthus
roseus)
PF00107
(ADH_zinc_N)
PF08240
(ADH_N)
5 ILE A 364
LEU A 368
GLY A  46
ASP A  51
GLY A  69
None
1.07A 4bwlC-5h82A:
undetectable
4bwlC-5h82A:
22.87
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ihw SERINE-ASPARTATE
REPEAT-CONTAINING
PROTEIN E


(Staphylococcus
aureus)
PF10425
(SdrG_C_C)
5 ILE A 564
THR A 486
GLY A 470
GLY A 567
SER A 585
None
1.14A 4bwlC-5ihwA:
undetectable
4bwlC-5ihwA:
19.35
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ihy UNCHARACTERIZED
PROTEIN


(Bacillus
subtilis)
PF01966
(HD)
5 ILE A 200
LEU A 193
GLY A 150
GLY A 147
PHE A 138
None
1.08A 4bwlC-5ihyA:
undetectable
4bwlC-5ihyA:
22.29
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5jrj PROTEIN RECA

(Herbaspirillum
seropedicae)
PF00154
(RecA)
5 ILE A  71
ASP A  55
GLY A  50
SER A  51
PHE A 267
None
1.07A 4bwlC-5jrjA:
undetectable
4bwlC-5jrjA:
22.93
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5kzd N-ACETYLNEURAMINATE
LYASE


(Staphylococcus
aureus)
PF00701
(DHDPS)
5 GLY A 189
ASP A 191
GLU A 192
GLY A 207
SER A 208
RCJ  A 301 (-3.6A)
RCJ  A 301 (-2.5A)
RCJ  A 301 (-3.1A)
RCJ  A 301 (-3.2A)
RCJ  A 301 (-3.2A)
0.37A 4bwlC-5kzdA:
39.4
4bwlC-5kzdA:
36.60
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5m0k BETA-XYLANASE

(Cellulomonas
flavigena)
no annotation 5 ILE A 262
GLY A  17
TYR A  15
ASP A  39
GLY A   6
None
1.24A 4bwlC-5m0kA:
9.9
4bwlC-5m0kA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ue1 5'-METHYLTHIOADENOSI
NE/S-ADENOSYLHOMOCYS
TEINE NUCLEOSIDASE


(Aliivibrio
fischeri)
PF01048
(PNP_UDP_1)
5 GLY A   7
GLU A 175
GLY A  75
SER A  76
PHE A 208
None
TRS  A 302 (-2.7A)
TRS  A 302 ( 4.9A)
TRS  A 302 (-2.8A)
TRS  A 302 (-3.9A)
0.84A 4bwlC-5ue1A:
undetectable
4bwlC-5ue1A:
23.08
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5vug UNCHARACTERIZED
PROTEIN RV2277C


(Mycobacterium
tuberculosis)
PF03009
(GDPD)
5 ILE A 110
LEU A 106
THR A 142
GLY A 143
GLY A 146
None
1.12A 4bwlC-5vugA:
3.2
4bwlC-5vugA:
22.80
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5xhu FERREDOXIN--NADP
REDUCTASE


(Bacillus
subtilis)
no annotation 5 ILE A  70
LEU A  69
GLY A  15
GLY A  19
PHE A 302
None
1.07A 4bwlC-5xhuA:
undetectable
4bwlC-5xhuA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5xn8 GLYCEROL
DEHYDROGENASE


(unidentified)
PF00465
(Fe-ADH)
5 LEU A 127
GLY A 249
GLU A 178
GLY A 244
SER A 241
None
1.21A 4bwlC-5xn8A:
3.0
4bwlC-5xn8A:
24.25
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6bxa TOLL-LIKE RECEPTOR
5B, VARIABLE
LYMPHOCYTE RECEPTOR
B CHIMERA


(Eptatretus
burgeri;
Danio rerio)
no annotation 5 ILE A 258
LEU A 234
THR A 256
GLY A 255
GLY A 288
None
1.17A 4bwlC-6bxaA:
undetectable
4bwlC-6bxaA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6bxa TOLL-LIKE RECEPTOR
5B, VARIABLE
LYMPHOCYTE RECEPTOR
B CHIMERA
VARIABLE LYMPHOCYTE
RECEPTOR 2


(Eptatretus
burgeri;
Danio rerio;
Petromyzon
marinus)
no annotation
no annotation
5 ILE A  35
LEU A  56
ASP C  34
GLY C  55
SER C  36
None
1.23A 4bwlC-6bxaA:
undetectable
4bwlC-6bxaA:
undetectable