SIMILAR PATTERNS OF AMINO ACIDS FOR 4BVA_A_T3A1314_1

List of similar pattern of amino acids derived from ASSAM search

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click link on the last column to view superposed patterns of amino acids in NGL viewer)
(Note that only 3-12 residue patterns can be used for ASSAM searches)
Filter list by:
Hit Macromolecule/
Organism		 Pfam Res. Interface HETATM RMSD Dali Z-score Seq. Identity (%) View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1egx VASODILATOR-STIMULAT
ED PHOSPHOPROTEIN

(Homo sapiens) 		PF00568
(WH1) 		5 VAL A  61
GLY A  51
VAL A  36
PHE A  33
PRO A  25
 None
 1.46A 4bvaA-1egxA:
undetectable		 4bvaA-1egxA:
18.26
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1evh PROTEIN (MENA EVH1
DOMAIN)

(Mus musculus) 		PF00568
(WH1) 		5 VAL A  59
GLY A  50
VAL A  35
PHE A  32
PRO A  25
 None
 1.27A 4bvaA-1evhA:
2.0		 4bvaA-1evhA:
17.34
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1evj GLUCOSE-FRUCTOSE
OXIDOREDUCTASE

(Zymomonas
mobilis) 		PF01408
(GFO_IDH_MocA)
PF02894
(GFO_IDH_MocA_C) 		5 VAL A 249
PHE A 246
GLY A 209
ARG A 245
PRO A 195
 None
 1.34A 4bvaA-1evjA:
6.7		 4bvaA-1evjA:
23.31
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1fhi FRAGILE HISTIDINE
TRIAD PROTEIN

(Homo sapiens) 		PF01230
(HIT) 		5 VAL A  99
GLY A  66
VAL A  68
PHE A  73
HIS A  72
 None
 1.40A 4bvaA-1fhiA:
undetectable		 4bvaA-1fhiA:
19.09
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1m6j TRIOSEPHOSPHATE
ISOMERASE

(Entamoeba
histolytica) 		PF00121
(TIM) 		5 VAL A 240
PHE A 238
GLY A   9
VAL A  42
PRO A 223
 None
 1.28A 4bvaA-1m6jA:
undetectable		 4bvaA-1m6jA:
22.56
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1nbw GLYCEROL DEHYDRATASE
REACTIVASE BETA
SUBUNIT

(Klebsiella
pneumoniae) 		PF02288
(Dehydratase_MU) 		5 VAL B  34
GLY B 105
HIS B  76
SER B  58
PRO B   6
 None
 1.33A 4bvaA-1nbwB:
undetectable		 4bvaA-1nbwB:
16.27
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1qle CYTOCHROME C OXIDASE
POLYPEPTIDE I-BETA

(Paracoccus
denitrificans) 		PF00115
(COX1) 		5 VAL A 385
GLY A 386
VAL A 415
PHE A 460
HIS A 413
 None
None
HEA  A 602 (-4.2A)
None
HEA  A 601 (-3.4A)
 1.45A 4bvaA-1qleA:
undetectable		 4bvaA-1qleA:
21.85
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1u6r CREATINE KINASE, M
CHAIN

(Oryctolagus
cuniculus) 		PF00217
(ATP-gua_Ptrans)
PF02807
(ATP-gua_PtransN) 		5 ARG A 250
PHE A 249
VAL A 254
PHE A 252
GLU A 247
 None
 1.42A 4bvaA-1u6rA:
undetectable		 4bvaA-1u6rA:
21.46
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1uek 4-(CYTIDINE
5'-DIPHOSPHO)-2C-MET
HYL-D-ERYTHRITOL
KINASE

(Thermus
thermophilus) 		PF00288
(GHMP_kinases_N)
PF08544
(GHMP_kinases_C) 		5 VAL A 228
PHE A 237
GLY A 239
VAL A 155
PHE A 157
 None
 0.60A 4bvaA-1uekA:
undetectable		 4bvaA-1uekA:
24.16
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1uew MEMBRANE ASSOCIATED
GUANYLATE KINASE
INVERTED-2 (MAGI-2)

(Homo sapiens) 		PF00595
(PDZ) 		5 VAL A  27
PHE A  26
GLY A  48
VAL A  64
SER A  54
 None
 1.45A 4bvaA-1uewA:
undetectable		 4bvaA-1uewA:
16.77
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1vdh MUCONOLACTONE
ISOMERASE-LIKE
PROTEIN

(Thermus
thermophilus) 		PF06778
(Chlor_dismutase) 		5 VAL A  67
PHE A 233
GLY A 235
VAL A 142
PHE A 144
 None
 0.43A 4bvaA-1vdhA:
undetectable		 4bvaA-1vdhA:
21.61
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2dwu GLUTAMATE RACEMASE

(Bacillus
anthracis) 		PF01177
(Asp_Glu_race) 		5 VAL A   9
PHE A  68
GLY A  11
VAL A  12
ARG A 238
 None
 1.26A 4bvaA-2dwuA:
2.8		 4bvaA-2dwuA:
25.46
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2glx 1,5-ANHYDRO-D-FRUCTO
SE REDUCTASE

(Ensifer
adhaerens) 		PF01408
(GFO_IDH_MocA)
PF02894
(GFO_IDH_MocA_C) 		5 VAL A 317
GLY A 314
VAL A 179
HIS A 151
GLU A 211
 None
 1.35A 4bvaA-2glxA:
8.7		 4bvaA-2glxA:
22.40
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2i99 MU-CRYSTALLIN
HOMOLOG

(Homo sapiens) 		PF02423
(OCD_Mu_crystall) 		6 ARG A  47
GLY A  60
VAL A  77
SER A 229
PRO A 231
GLU A 257
 None
None
None
NDP  A 502 ( 4.0A)
None
None
 0.72A 4bvaA-2i99A:
21.4		 4bvaA-2i99A:
82.93
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2i99 MU-CRYSTALLIN
HOMOLOG

(Homo sapiens) 		PF02423
(OCD_Mu_crystall) 		6 ARG A  47
VAL A  49
GLY A  60
VAL A  77
PRO A 231
GLU A 257
 None
 0.64A 4bvaA-2i99A:
21.4		 4bvaA-2i99A:
82.93
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2i99 MU-CRYSTALLIN
HOMOLOG

(Homo sapiens) 		PF02423
(OCD_Mu_crystall) 		7 ARG A  47
VAL A  77
HIS A  92
SER A 229
PRO A 231
TRP A 233
GLU A 257
 None
None
NDP  A 502 (-3.9A)
NDP  A 502 ( 4.0A)
None
None
None
 0.81A 4bvaA-2i99A:
21.4		 4bvaA-2i99A:
82.93
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2j9l CHLORIDE CHANNEL
PROTEIN 5

(Homo sapiens) 		PF00571
(CBS) 		5 VAL A 713
VAL A 699
HIS A 731
ARG A 589
PRO A 588
 None
 1.49A 4bvaA-2j9lA:
undetectable		 4bvaA-2j9lA:
20.18
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2obv S-ADENOSYLMETHIONINE
SYNTHETASE ISOFORM
TYPE-1

(Homo sapiens) 		PF00438
(S-AdoMet_synt_N)
PF02772
(S-AdoMet_synt_M)
PF02773
(S-AdoMet_synt_C) 		5 VAL A 361
GLY A 358
VAL A 130
HIS A 122
PRO A  50
 None
 1.31A 4bvaA-2obvA:
undetectable		 4bvaA-2obvA:
23.84
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2wu5 SUCCINATE
DEHYDROGENASE
FLAVOPROTEIN SUBUNIT

(Escherichia
coli) 		PF00890
(FAD_binding_2)
PF02910
(Succ_DH_flav_C) 		5 PHE A 193
GLY A 179
PHE A   8
ARG A   6
PRO A   4
 None
 1.20A 4bvaA-2wu5A:
2.8		 4bvaA-2wu5A:
19.97
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3b2z ADAMTS-4

(Homo sapiens) 		PF01421
(Reprolysin) 		5 PHE A 367
GLY A 336
VAL A 335
SER A 408
TRP A 404
 None
 1.23A 4bvaA-3b2zA:
undetectable		 4bvaA-3b2zA:
22.85
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3cq9 UNCHARACTERIZED
PROTEIN LP_1622

(Lactobacillus
plantarum) 		PF04263
(TPK_catalytic) 		5 VAL A  28
GLY A  29
VAL A  48
PRO A  94
TRP A 125
 None
 1.49A 4bvaA-3cq9A:
2.7		 4bvaA-3cq9A:
20.94
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3dcd GALACTOSE MUTAROTASE
RELATED ENZYME

(Lactobacillus
acidophilus) 		PF01263
(Aldose_epim) 		5 ARG A 112
PHE A 111
VAL A 129
PHE A 109
GLU A  84
 None
 1.32A 4bvaA-3dcdA:
undetectable		 4bvaA-3dcdA:
21.94
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3eqn GLUCAN
1,3-BETA-GLUCOSIDASE

(Phanerochaete
chrysosporium) 		PF12708
(Pectate_lyase_3) 		5 VAL A 503
PHE A 491
GLY A 555
VAL A 571
HIS A 523
 None
 1.37A 4bvaA-3eqnA:
undetectable		 4bvaA-3eqnA:
18.60
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3iau THREONINE DEAMINASE

(Solanum
lycopersicum) 		PF00291
(PALP) 		5 VAL A 273
GLY A 217
VAL A 216
SER A 252
ARG A 258
 None
LLP  A  91 ( 3.4A)
LLP  A  91 ( 4.3A)
None
None
 1.42A 4bvaA-3iauA:
2.9		 4bvaA-3iauA:
24.87
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3krs TRIOSEPHOSPHATE
ISOMERASE

(Cryptosporidium
parvum) 		PF00121
(TIM) 		5 VAL A 233
PHE A 231
GLY A   8
VAL A  37
PRO A 216
 None
 1.35A 4bvaA-3krsA:
undetectable		 4bvaA-3krsA:
23.41
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3nuz PUTATIVE ACETYL
XYLAN ESTERASE

(Bacteroides
fragilis) 		PF12715
(Abhydrolase_7) 		5 VAL A 393
PHE A 388
GLY A 395
SER A 256
GLU A 335
 None
 1.38A 4bvaA-3nuzA:
undetectable		 4bvaA-3nuzA:
23.29
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3p1z PUTATIVE
UNCHARACTERIZED
PROTEIN
TRNA-SPLICING
ENDONUCLEASE

(Aeropyrum
pernix) 		PF01974
(tRNA_int_endo)
PF02778
(tRNA_int_endo_N) 		5 VAL B 138
PHE B 136
VAL B 112
PHE B 110
SER A 168
 None
 1.47A 4bvaA-3p1zB:
undetectable		 4bvaA-3p1zB:
22.30
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3p4s FUMARATE REDUCTASE
FLAVOPROTEIN SUBUNIT

(Escherichia
coli) 		PF00890
(FAD_binding_2)
PF02910
(Succ_DH_flav_C) 		5 ARG A 115
PHE A 116
GLY A 118
ARG A 114
GLU A 122
 None
3NP  A 602 (-4.7A)
None
None
None
 1.29A 4bvaA-3p4sA:
3.0		 4bvaA-3p4sA:
20.14
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3q2h A DISINTEGRIN AND
METALLOPROTEINASE
WITH THROMBOSPONDIN
MOTIFS 1

(Homo sapiens) 		PF01421
(Reprolysin) 		5 PHE A 155
GLY A 124
VAL A 123
SER A 195
TRP A 191
 None
None
QHF  A   1 (-4.7A)
None
None
 1.13A 4bvaA-3q2hA:
undetectable		 4bvaA-3q2hA:
22.10
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3qvu SULFOTRANSFERASE 1A1

(Homo sapiens) 		PF00685
(Sulfotransfer_1) 		5 VAL A 167
GLY A 165
VAL A 164
SER A 157
PRO A 152
 None
 1.33A 4bvaA-3qvuA:
undetectable		 4bvaA-3qvuA:
23.45
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3wob HYPOTHETICAL PROTEIN

(Sus scrofa) 		PF01419
(Jacalin) 		5 PHE A  45
GLY A  68
SER A  64
TRP A  63
GLU A  65
 None
 1.15A 4bvaA-3wobA:
undetectable		 4bvaA-3wobA:
15.82
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3wv7 HMD CO-OCCURRING
PROTEIN HCGE

(Methanothermobacter
marburgensis) 		PF00899
(ThiF) 		5 VAL A 138
GLY A 176
VAL A 146
ARG A  27
GLU A 108
 None
 1.43A 4bvaA-3wv7A:
6.2		 4bvaA-3wv7A:
21.93
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4bko PUTATIVE REDUCTASE
BURPS305_1051

(Burkholderia
pseudomallei) 		PF07055
(Eno-Rase_FAD_bd)
PF12241
(Enoyl_reductase)
PF12242
(Eno-Rase_NADH_b) 		5 VAL A 139
GLY A  48
VAL A  72
PHE A  74
SER A 114
 GOL  A1400 ( 4.7A)
None
None
GOL  A1400 (-4.5A)
None
 1.22A 4bvaA-4bkoA:
4.2		 4bvaA-4bkoA:
25.06
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4fl0 AMINOTRANSFERASE
ALD1

(Arabidopsis
thaliana) 		PF00155
(Aminotran_1_2) 		5 ARG A 292
VAL A 291
GLY A 290
PHE A 282
SER A 139
 PLP  A 501 (-3.1A)
None
None
None
None
 1.44A 4bvaA-4fl0A:
undetectable		 4bvaA-4fl0A:
22.31
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4nax GLUTATHIONE
S-TRANSFERASE,
N-TERMINAL DOMAIN
PROTEIN

(Pseudomonas
putida) 		PF00043
(GST_C)
PF02798
(GST_N) 		5 PHE A 139
GLY A 131
VAL A 133
HIS A 137
ARG A 195
 None
GDS  A 301 (-3.4A)
None
FMT  A 303 (-3.7A)
None
 1.45A 4bvaA-4naxA:
undetectable		 4bvaA-4naxA:
20.65
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4nuz ENDO-BETA-N-ACETYLGL
UCOSAMINIDASE F2

(Streptococcus
pyogenes) 		no annotation 5 VAL A 436
GLY A 408
VAL A 409
HIS A 411
SER A 346
 None
 1.26A 4bvaA-4nuzA:
undetectable		 4bvaA-4nuzA:
16.95
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4od5 4-HYDROXYBENZOATE
OCTAPRENYLTRANSFERAS
E

(Aeropyrum
pernix) 		PF01040
(UbiA) 		5 VAL A 171
GLY A 130
VAL A 132
SER A  12
PRO A 265
 None
None
PHB  A 302 (-4.6A)
GST  A 301 ( 4.1A)
None
 1.42A 4bvaA-4od5A:
undetectable		 4bvaA-4od5A:
24.36
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4uml GANGLIOSIDE-INDUCED
DIFFERENTIATION-ASSO
CIATED PROTEIN 2

(Homo sapiens) 		PF01661
(Macro) 		5 GLY A 130
VAL A 129
HIS A 127
SER A  86
PRO A  84
 None
 1.33A 4bvaA-4umlA:
undetectable		 4bvaA-4umlA:
22.41
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4x28 ACYL-COA
DEHYDROGENASE

(Mycobacterium
tuberculosis) 		no annotation 5 VAL D 152
GLY D 155
VAL D 185
ARG D 149
PRO D 164
 None
 1.45A 4bvaA-4x28D:
undetectable		 4bvaA-4x28D:
24.02
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4zxb INSULIN RECEPTOR

(Homo sapiens) 		PF00041
(fn3)
PF00757
(Furin-like)
PF01030
(Recep_L_domain) 		5 VAL E 254
PHE E 231
HIS E 247
ARG E  83
GLU E  30
 None
 1.49A 4bvaA-4zxbE:
undetectable		 4bvaA-4zxbE:
16.83
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ey9 LONG-CHAIN-FATTY-ACI
D--AMP LIGASE FADD32

(Mycobacterium
marinum) 		PF00501
(AMP-binding) 		5 ARG A 221
PHE A 277
GLY A 222
VAL A 223
GLU A 272
 None
 1.06A 4bvaA-5ey9A:
undetectable		 4bvaA-5ey9A:
22.48
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5i4j FERRITIN, DPS FAMILY
PROTEIN

(Nostoc
punctiforme) 		PF00210
(Ferritin) 		5 VAL A 111
VAL A  54
PHE A  52
HIS A  51
GLU A 107
 None
None
None
ZN  A 203 (-3.5A)
None
 1.45A 4bvaA-5i4jA:
undetectable		 4bvaA-5i4jA:
22.67
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5jay 8-AMINO-7-OXONONANOA
TE SYNTHASE

(Paraburkholderia
xenovorans) 		PF00155
(Aminotran_1_2) 		5 VAL A 181
GLY A 212
VAL A 215
SER A 369
PRO A 328
 None
 1.48A 4bvaA-5jayA:
2.5		 4bvaA-5jayA:
25.12
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5nks DIHYDROPYRIMIDINASE-
RELATED PROTEIN 4

(Homo sapiens) 		no annotation 5 VAL A 437
PHE A 434
GLY A 436
SER A 363
GLU A 367
 VAL  A 437 ( 0.6A)
PHE  A 434 ( 1.3A)
GLY  A 436 ( 0.0A)
SER  A 363 ( 0.0A)
GLU  A 367 ( 0.6A)
 1.36A 4bvaA-5nksA:
1.4		 4bvaA-5nksA:
21.12
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5nv8 EF-P ARGININE 32
RHAMNOSYL-TRANSFERAS
E

(Pseudomonas
putida) 		PF10093
(DUF2331) 		5 VAL A  20
GLY A  16
PHE A 276
SER A 128
PRO A 141
 None
TRH  A 401 (-3.1A)
None
None
None
 1.29A 4bvaA-5nv8A:
undetectable		 4bvaA-5nv8A:
25.30
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5oup PERFORIN-LIKE
PROTEIN 1

(Toxoplasma
gondii) 		no annotation 5 GLY A 672
VAL A 765
PHE A 670
SER A 531
ARG A 529
 None
 1.32A 4bvaA-5oupA:
undetectable		 4bvaA-5oupA:
11.42
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5sv6 EXTRACELLULAR
SOLUTE-BINDING
PROTEIN, FAMILY 3

(Methylophaga
aminisulfidivorans) 		PF00497
(SBP_bac_3) 		5 GLY A  99
VAL A  97
SER A  49
PRO A  47
GLU A  45
 None
 1.47A 4bvaA-5sv6A:
undetectable		 4bvaA-5sv6A:
24.17
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5vwn TRIOSEPHOSPHATE
ISOMERASE

(Trichomonas
vaginalis) 		no annotation 5 VAL A 226
PHE A 224
GLY A   7
VAL A  38
PRO A 209
 None
 1.26A 4bvaA-5vwnA:
2.6		 4bvaA-5vwnA:
11.34
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5xvh 6-PHOSPHOGLUCONATE
DEHYDROGENASE,
NAD-BINDING PROTEIN

(Pyrobaculum
calidifontis) 		no annotation 5 ARG A 102
VAL A 163
PHE A 115
PHE A 104
SER A  97
 None
 1.27A 4bvaA-5xvhA:
8.1		 4bvaA-5xvhA:
16.62
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6blg DTDP-4-AMINO-4,6-DID
EOXYGALACTOSE
TRANSAMINASE

(Klebsiella
pneumoniae) 		no annotation 5 ARG A 218
PHE A 217
PHE A 216
ARG A 213
GLU A 204
 None
 1.38A 4bvaA-6blgA:
3.0		 4bvaA-6blgA:
21.14
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6en3 ENDO-BETA-N-ACETYLGL
UCOSAMINIDASE
F2,MULTIFUNCTIONAL-A
UTOPROCESSING
REPEATS-IN-TOXIN

(Streptococcus
pyogenes;
Vibrio cholerae) 		no annotation 5 VAL A 436
GLY A 408
VAL A 409
HIS A 411
SER A 346
 None
None
None
None
NAG  A1303 ( 4.9A)
 1.23A 4bvaA-6en3A:
undetectable		 4bvaA-6en3A:
13.17