SIMILAR PATTERNS OF AMINO ACIDS FOR 4BKJ_B_STIB1000_2

List of similar pattern of amino acids derived from ASSAM search

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click link on the last column to view superposed patterns of amino acids in NGL viewer)
(Note that only 3-12 residue patterns can be used for ASSAM searches)
Filter list by:
Hit Macromolecule/
Organism		 Pfam Res. Interface HETATM RMSD Dali Z-score Seq. Identity (%) View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1k2p TYROSINE-PROTEIN
KINASE BTK

(Homo sapiens) 		PF07714
(Pkinase_Tyr) 		4 LYS A 430
LEU A 452
TYR A 476
MET A 477
 None
 1.28A 4bkjB-1k2pA:
23.4		 4bkjB-1k2pA:
29.84
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1k9a CARBOXYL-TERMINAL
SRC KINASE

(Rattus
norvegicus) 		PF00017
(SH2)
PF00018
(SH3_1)
PF07714
(Pkinase_Tyr) 		5 LYS A 222
LEU A 243
TYR A 268
MET A 269
ARG A 313
 None
 1.29A 4bkjB-1k9aA:
28.6		 4bkjB-1k9aA:
25.05
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1luf MUSCLE-SPECIFIC
TYROSINE KINASE
RECEPTOR MUSK

(Rattus
norvegicus) 		PF07714
(Pkinase_Tyr) 		4 LYS A 608
TYR A 656
MET A 657
ARG A 723
 None
 0.89A 4bkjB-1lufA:
36.1		 4bkjB-1lufA:
39.20
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1t46 HOMO SAPIENS V-KIT
HARDY-ZUCKERMAN 4
FELINE SARCOMA VIRAL
ONCOGENE HOMOLOG

(Homo sapiens) 		PF07714
(Pkinase_Tyr) 		4 LYS A 623
LEU A 647
TYR A 672
ARG A 791
 STI  A   3 (-3.7A)
None
STI  A   3 ( 4.0A)
None
 1.04A 4bkjB-1t46A:
33.7		 4bkjB-1t46A:
32.84
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1u5q SERINE/THREONINE
PROTEIN KINASE TAO2

(Rattus
norvegicus) 		PF00069
(Pkinase) 		4 LYS A  57
LEU A  83
TYR A 107
ARG A 150
 None
None
None
SEP  A 181 ( 2.8A)
 0.90A 4bkjB-1u5qA:
23.5		 4bkjB-1u5qA:
26.95
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1xng NH(3)-DEPENDENT
NAD(+) SYNTHETASE

(Helicobacter
pylori) 		PF02540
(NAD_synthase) 		4 LYS A  77
LEU A  44
TYR A  82
ARG A 169
 None
 1.33A 4bkjB-1xngA:
undetectable		 4bkjB-1xngA:
20.47
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1zlt SERINE/THREONINE-PRO
TEIN KINASE CHK1

(Homo sapiens) 		PF00069
(Pkinase) 		4 LYS A  38
LEU A  62
TYR A  86
ARG A 129
 HYM  A 400 (-3.2A)
None
HYM  A 400 (-4.7A)
SO4  A 901 (-2.9A)
 1.17A 4bkjB-1zltA:
20.2		 4bkjB-1zltA:
24.11
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2bd0 SEPIAPTERIN
REDUCTASE

(Chlorobaculum
tepidum) 		PF00106
(adh_short) 		4 LEU A   6
TYR A 175
MET A 172
ARG A  75
 None
 1.47A 4bkjB-2bd0A:
undetectable		 4bkjB-2bd0A:
21.89
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2dq7 PROTO-ONCOGENE
TYROSINE-PROTEIN
KINASE FYN

(Homo sapiens) 		PF07714
(Pkinase_Tyr) 		5 LYS X  39
LEU X  61
TYR X  84
MET X  85
ARG X 129
 STU  X 902 (-3.1A)
None
STU  X 902 (-4.6A)
None
PTR  X 160 ( 3.4A)
 1.17A 4bkjB-2dq7X:
29.9		 4bkjB-2dq7X:
35.24
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2gcd SERINE/THREONINE-PRO
TEIN KINASE TAO2

(Rattus
norvegicus) 		PF00069
(Pkinase) 		4 LYS A  57
LEU A  83
TYR A 107
ARG A 150
 STU  A 400 ( 4.5A)
None
STU  A 400 (-4.5A)
SEP  A 181 ( 2.9A)
 1.02A 4bkjB-2gcdA:
24.4		 4bkjB-2gcdA:
28.41
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2h8h PROTO-ONCOGENE
TYROSINE-PROTEIN
KINASE SRC

(Homo sapiens) 		PF00017
(SH2)
PF00018
(SH3_1)
PF07714
(Pkinase_Tyr) 		4 LEU A 317
TYR A 340
MET A 341
ARG A 385
 None
H8H  A 534 (-4.3A)
None
None
 0.92A 4bkjB-2h8hA:
29.0		 4bkjB-2h8hA:
25.98
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2i1j MOESIN

(Spodoptera
frugiperda) 		PF00373
(FERM_M)
PF00769
(ERM)
PF09379
(FERM_N)
PF09380
(FERM_C) 		4 LEU A 216
TYR A 116
MET A 539
ARG A 568
 None
 1.44A 4bkjB-2i1jA:
undetectable		 4bkjB-2i1jA:
20.76
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2i6l MITOGEN-ACTIVATED
PROTEIN KINASE 6

(Homo sapiens) 		PF00069
(Pkinase) 		4 LYS A  49
LEU A  72
TYR A 110
MET A 111
 None
 1.12A 4bkjB-2i6lA:
22.0		 4bkjB-2i6lA:
27.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2nyk M157

(Murid
betaherpesvirus
1) 		PF11624
(M157) 		4 LEU A  83
TYR A 151
MET A 152
ARG A 122
 None
 1.47A 4bkjB-2nykA:
undetectable		 4bkjB-2nykA:
18.10
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2og8 PROTO-ONCOGENE
TYROSINE-PROTEIN
KINASE LCK

(Homo sapiens) 		PF07714
(Pkinase_Tyr) 		4 LEU A 295
TYR A 318
MET A 319
ARG A 363
 1N8  A 501 ( 3.9A)
1N8  A 501 ( 3.7A)
1N8  A 501 ( 4.4A)
None
 0.84A 4bkjB-2og8A:
31.4		 4bkjB-2og8A:
37.81
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2q6k CHLORINASE

(Salinispora
tropica) 		PF01887
(SAM_adeno_trans) 		4 LYS A   1
LEU A  92
MET A  26
ARG A 154
 None
 1.36A 4bkjB-2q6kA:
undetectable		 4bkjB-2q6kA:
21.75
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2yhe SEC-ALKYL SULFATASE

(Pseudomonas sp.
DSM 6611) 		PF00753
(Lactamase_B)
PF14863
(Alkyl_sulf_dimr)
PF14864
(Alkyl_sulf_C) 		4 LEU A 661
TYR A 521
MET A 505
ARG A 453
 None
 1.12A 4bkjB-2yheA:
undetectable		 4bkjB-2yheA:
19.21
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3d7u TYROSINE-PROTEIN
KINASE CSK

(Homo sapiens) 		PF07714
(Pkinase_Tyr) 		5 LYS A 222
LEU A 243
TYR A 268
MET A 269
ARG A 313
 None
 1.29A 4bkjB-3d7uA:
24.3		 4bkjB-3d7uA:
32.72
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3e3b CASEIN KINASE II
SUBUNIT ALPHA'

(Homo sapiens) 		PF00069
(Pkinase) 		4 LYS X  69
LEU X  89
TYR X 116
ARG X 156
 CCK  X 351 (-3.5A)
None
CCK  X 351 (-4.3A)
None
 1.10A 4bkjB-3e3bX:
5.2		 4bkjB-3e3bX:
22.89
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3nuu PKB-LIKE

(Homo sapiens) 		PF00069
(Pkinase) 		4 LYS A 111
LEU A 137
TYR A 161
ARG A 204
 SO4  A   5 (-2.8A)
None
None
SEP  A 241 ( 3.4A)
 1.18A 4bkjB-3nuuA:
22.8		 4bkjB-3nuuA:
25.45
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3oz6 MITOGEN-ACTIVATED
PROTEIN KINASE 1,
SERINE/THREONINE
PROTEIN KINASE

(Cryptosporidium
parvum) 		PF00069
(Pkinase) 		4 LEU A  65
TYR A  92
MET A  93
ARG A 133
 None
 1.38A 4bkjB-3oz6A:
19.8		 4bkjB-3oz6A:
25.18
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3ppz SERINE/THREONINE-PRO
TEIN KINASE CTR1

(Arabidopsis
thaliana) 		PF07714
(Pkinase_Tyr) 		4 LYS A 578
LEU A 603
TYR A 627
ARG A 675
 STU  A   1 (-3.5A)
None
STU  A   1 (-4.4A)
SEP  A 710 ( 3.6A)
 1.02A 4bkjB-3ppzA:
27.6		 4bkjB-3ppzA:
31.93
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4ckr EPITHELIAL DISCOIDIN
DOMAIN-CONTAINING
RECEPTOR 1

(Homo sapiens) 		PF07714
(Pkinase_Tyr) 		5 LYS A 655
LEU A 679
TYR A 703
MET A 704
ARG A 765
 DI1  A1000 (-3.9A)
DI1  A1000 (-4.5A)
DI1  A1000 (-4.0A)
None
None
 0.53A 4bkjB-4ckrA:
45.8		 4bkjB-4ckrA:
100.00
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4gl9 TYROSINE-PROTEIN
KINASE

(Mus musculus) 		PF07714
(Pkinase_Tyr) 		4 LYS A 882
LEU A 905
TYR A 931
ARG A 975
 IZA  A2001 ( 4.7A)
None
None
None
 1.14A 4bkjB-4gl9A:
28.2		 4bkjB-4gl9A:
33.23
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4jr7 CASEIN KINASE II
SUBUNIT ALPHA

(Saccharomyces
cerevisiae) 		PF00069
(Pkinase) 		4 LYS A  69
LEU A  89
TYR A 154
ARG A 194
 GNP  A 401 (-3.3A)
None
GNP  A 401 ( 4.5A)
None
 1.33A 4bkjB-4jr7A:
18.9		 4bkjB-4jr7A:
21.05
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4l68 LEUCINE-RICH REPEAT
PROTEIN KINASE-LIKE
PROTEIN

(Arabidopsis
thaliana) 		PF07714
(Pkinase_Tyr) 		4 LYS A 335
LEU A 357
TYR A 381
MET A 382
 None
 0.89A 4bkjB-4l68A:
18.9		 4bkjB-4l68A:
26.08
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4ueu TYROSINE KINASE AS -
A COMMON ANCESTOR OF
SRC AND ABL

(synthetic
construct) 		PF07714
(Pkinase_Tyr) 		5 LYS A  37
LEU A  59
TYR A  83
MET A  84
ARG A 128
 None
None
ACP  A1264 ( 4.5A)
None
None
 1.28A 4bkjB-4ueuA:
29.8		 4bkjB-4ueuA:
39.81
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4xuf RECEPTOR-TYPE
TYROSINE-PROTEIN
KINASE FLT3

(Homo sapiens) 		PF07714
(Pkinase_Tyr) 		4 LYS A 644
LEU A 668
TYR A 693
ARG A 810
 P30  A1001 ( 4.0A)
None
P30  A1001 ( 4.4A)
None
 1.16A 4bkjB-4xufA:
25.1		 4bkjB-4xufA:
33.44
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5a31 ANAPHASE-PROMOTING
COMPLEX SUBUNIT 1

(Homo sapiens) 		PF12859
(ANAPC1) 		4 LEU A1585
TYR A1326
MET A1329
ARG A1475
 None
 1.47A 4bkjB-5a31A:
undetectable		 4bkjB-5a31A:
12.52
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5a31 ANAPHASE-PROMOTING
COMPLEX SUBUNIT 1

(Homo sapiens) 		PF12859
(ANAPC1) 		4 LYS A1700
LEU A1747
TYR A1708
ARG A 956
 None
 1.29A 4bkjB-5a31A:
undetectable		 4bkjB-5a31A:
12.52
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5a53 REGULATOR OF
RIBOSOME
BIOSYNTHESIS
RIBOSOME BIOGENESIS
PROTEIN RPF2

(Saccharomyces
cerevisiae) 		PF04427
(Brix)
no annotation 		4 LYS C 138
LEU C  86
MET C 184
ARG B 101
 None
 1.33A 4bkjB-5a53C:
undetectable		 4bkjB-5a53C:
22.42
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5e72 N2,
N2-DIMETHYLGUANOSINE
TRNA
METHYLTRANSFERASE

(Thermococcus
kodakarensis) 		PF01170
(UPF0020)
PF02926
(THUMP) 		4 LEU A   2
TYR A  34
MET A  93
ARG A  51
 None
 1.34A 4bkjB-5e72A:
undetectable		 4bkjB-5e72A:
22.10
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ig1 CAMK/CAMK2 PROTEIN
KINASE

(Salpingoeca
rosetta) 		PF00069
(Pkinase) 		4 LYS A  47
LEU A  72
TYR A  96
ARG A 139
 None
None
PO4  A 401 (-4.8A)
None
 1.46A 4bkjB-5ig1A:
23.3		 4bkjB-5ig1A:
26.05
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5u94 SERINE/THREONINE-PRO
TEIN KINASE PKNB

(Mycobacterium
tuberculosis) 		no annotation 4 LYS A  40
LEU A  66
TYR A  94
ARG A 137
 G93  A 301 (-3.0A)
None
None
None
 1.38A 4bkjB-5u94A:
24.5		 4bkjB-5u94A:
15.50
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ub6 PHOSPHATE-BINDING
PROTEIN

(Xanthomonas
citri) 		no annotation 4 LEU A 111
TYR A  83
MET A  80
ARG A  60
 None
 1.48A 4bkjB-5ub6A:
undetectable		 4bkjB-5ub6A:
13.86
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ucg STAGE II SPORULATION
PROTEIN E

(Bacillus
subtilis) 		PF07228
(SpoIIE) 		4 LYS A 693
TYR A 622
MET A 615
ARG A 500
 None
 1.43A 4bkjB-5ucgA:
undetectable		 4bkjB-5ucgA:
22.63
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5wxl REGULATOR OF
RIBOSOME
BIOSYNTHESIS
RIBOSOME BIOGENESIS
PROTEIN RPF2

(Saccharomyces
cerevisiae) 		PF04427
(Brix)
PF04939
(RRS1) 		4 LYS A 138
LEU A  86
MET A 184
ARG B 101
 None
 1.33A 4bkjB-5wxlA:
undetectable		 4bkjB-5wxlA:
22.46
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5xvu CASEIN KINASE 2,
ALPHA SUBUNIT

(Plasmodium
falciparum) 		PF00069
(Pkinase) 		4 LYS A  72
LEU A  92
TYR A 119
ARG A 159
 ATP  A 403 (-3.2A)
None
None
SO4  A 401 (-3.0A)
 1.35A 4bkjB-5xvuA:
20.0		 4bkjB-5xvuA:
19.30
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ybb TYPE I
RESTRICTION-MODIFICA
TION SYSTEM
METHYLTRANSFERASE
SUBUNIT

(Caldanaerobacter
subterraneus) 		no annotation 4 LEU A  43
TYR A  33
MET A  21
ARG A 112
 None
 1.19A 4bkjB-5ybbA:
undetectable		 4bkjB-5ybbA:
20.36
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5zya SPLICING FACTOR 3B
SUBUNIT 1

(Homo sapiens) 		no annotation 4 LEU C 747
TYR C 761
MET C 757
ARG C 702
 None
 1.46A 4bkjB-5zyaC:
undetectable		 4bkjB-5zyaC:
12.70
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6b3e CYCLIN-DEPENDENT
KINASE 12

(Homo sapiens) 		no annotation 4 LEU A 781
TYR A 815
MET A 816
ARG A 773
 None
CJM  A1102 (-4.1A)
None
None
 1.31A 4bkjB-6b3eA:
22.6		 4bkjB-6b3eA:
15.04
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6b3e CYCLIN-DEPENDENT
KINASE 12

(Homo sapiens) 		no annotation 4 LEU A 781
TYR A 815
MET A 816
ARG A 858
 None
CJM  A1102 (-4.1A)
None
TPO  A 893 ( 3.0A)
 0.88A 4bkjB-6b3eA:
22.6		 4bkjB-6b3eA:
15.04
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6b3e CYCLIN-DEPENDENT
KINASE 12

(Homo sapiens) 		no annotation 4 LYS A 756
LEU A 781
MET A 816
ARG A 858
 None
None
None
TPO  A 893 ( 3.0A)
 1.12A 4bkjB-6b3eA:
22.6		 4bkjB-6b3eA:
15.04
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6c9d SERINE/THREONINE-PRO
TEIN KINASE
MARK1,SERINE/THREONI
NE-PROTEIN KINASE
MARK1

(Homo sapiens) 		no annotation 4 LYS A  89
LEU A 114
TYR A 138
ARG A 181
 None
 1.14A 4bkjB-6c9dA:
21.1		 4bkjB-6c9dA:
11.78