SIMILAR PATTERNS OF AMINO ACIDS FOR 4BKJ_B_STIB1000

List of similar pattern of amino acids derived from ASSAM search

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click link on the last column to view superposed patterns of amino acids in NGL viewer)
(Note that only 3-12 residue patterns can be used for ASSAM searches)
Filter list by:
Hit Macromolecule/
Organism		 Pfam Res. Interface HETATM RMSD Dali Z-score Seq. Identity (%) View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1opk PROTO-ONCOGENE
TYROSINE-PROTEIN
KINASE ABL1

(Mus musculus) 		PF00017
(SH2)
PF00018
(SH3_1)
PF07714
(Pkinase_Tyr) 		7 VAL A 275
ALA A 288
GLU A 305
MET A 309
THR A 334
LEU A 389
ALA A 399
 P16  A   2 (-4.5A)
P16  A   2 (-3.4A)
P16  A   2 (-4.2A)
P16  A   2 (-3.3A)
P16  A   2 (-3.7A)
P16  A   2 (-4.4A)
P16  A   2 (-3.5A)
 0.80A 4bkjB-1opkA:
28.8		 4bkjB-1opkA:
26.49
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1py5 TGF-BETA RECEPTOR
TYPE I

(Homo sapiens) 		PF00069
(Pkinase)
PF08515
(TGF_beta_GS) 		6 VAL A 219
ALA A 230
GLU A 245
ILE A 248
LEU A 340
ALA A 350
 PY1  A 700 ( 4.7A)
PY1  A 700 (-3.5A)
PY1  A 700 ( 4.9A)
None
PY1  A 700 (-4.4A)
PY1  A 700 ( 4.2A)
 0.96A 4bkjB-1py5A:
24.4		 4bkjB-1py5A:
25.36
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1t46 HOMO SAPIENS V-KIT
HARDY-ZUCKERMAN 4
FELINE SARCOMA VIRAL
ONCOGENE HOMOLOG

(Homo sapiens) 		PF07714
(Pkinase_Tyr) 		6 VAL A 603
ALA A 621
GLU A 640
THR A 670
LEU A 799
ASP A 810
 STI  A   3 ( 4.6A)
STI  A   3 (-3.5A)
STI  A   3 (-3.6A)
STI  A   3 (-3.2A)
STI  A   3 (-4.4A)
STI  A   3 (-3.9A)
 0.78A 4bkjB-1t46A:
33.7		 4bkjB-1t46A:
32.84
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1u59 TYROSINE-PROTEIN
KINASE ZAP-70

(Homo sapiens) 		PF07714
(Pkinase_Tyr) 		6 VAL A 352
ALA A 367
GLU A 386
ILE A 389
MET A 390
LEU A 468
 STU  A 100 (-4.8A)
STU  A 100 (-3.2A)
None
None
None
STU  A 100 (-4.5A)
 0.70A 4bkjB-1u59A:
28.8		 4bkjB-1u59A:
33.44
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2dq7 PROTO-ONCOGENE
TYROSINE-PROTEIN
KINASE FYN

(Homo sapiens) 		PF07714
(Pkinase_Tyr) 		7 ALA X  37
GLU X  54
ILE X  57
MET X  58
THR X  82
ALA X 147
ASP X 148
 STU  X 902 (-3.1A)
STU  X 902 ( 4.4A)
None
None
STU  X 902 (-4.1A)
STU  X 902 ( 4.1A)
STU  X 902 (-3.6A)
 1.01A 4bkjB-2dq7X:
29.9		 4bkjB-2dq7X:
35.24
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2dq7 PROTO-ONCOGENE
TYROSINE-PROTEIN
KINASE FYN

(Homo sapiens) 		PF07714
(Pkinase_Tyr) 		8 VAL X  25
ALA X  37
GLU X  54
ILE X  57
MET X  58
THR X  82
LEU X 137
ALA X 147
 STU  X 902 ( 4.8A)
STU  X 902 (-3.1A)
STU  X 902 ( 4.4A)
None
None
STU  X 902 (-4.1A)
STU  X 902 (-4.4A)
STU  X 902 ( 4.1A)
 0.88A 4bkjB-2dq7X:
29.9		 4bkjB-2dq7X:
35.24
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2hen EPHRIN TYPE-B
RECEPTOR 2

(Mus musculus) 		PF07714
(Pkinase_Tyr) 		7 ALA A 659
ILE A 681
MET A 682
ILE A 691
THR A 707
LEU A 761
ASP A 772
 ADP  A 400 (-3.2A)
None
None
None
ADP  A 400 (-4.7A)
ADP  A 400 ( 4.7A)
ADP  A 400 ( 4.8A)
 1.08A 4bkjB-2henA:
29.8		 4bkjB-2henA:
37.08
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2hen EPHRIN TYPE-B
RECEPTOR 2

(Mus musculus) 		PF07714
(Pkinase_Tyr) 		6 VAL A 643
ALA A 659
GLU A 678
MET A 682
ILE A 691
ASP A 772
 ADP  A 400 ( 4.4A)
ADP  A 400 (-3.2A)
ADP  A 400 ( 4.9A)
None
None
ADP  A 400 ( 4.8A)
 1.00A 4bkjB-2henA:
29.8		 4bkjB-2henA:
37.08
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2hen EPHRIN TYPE-B
RECEPTOR 2

(Mus musculus) 		PF07714
(Pkinase_Tyr) 		7 VAL A 643
ALA A 659
MET A 682
ILE A 691
THR A 707
LEU A 761
ASP A 772
 ADP  A 400 ( 4.4A)
ADP  A 400 (-3.2A)
None
None
ADP  A 400 (-4.7A)
ADP  A 400 ( 4.7A)
ADP  A 400 ( 4.8A)
 1.23A 4bkjB-2henA:
29.8		 4bkjB-2henA:
37.08
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2hk5 TYROSINE-PROTEIN
KINASE HCK

(Homo sapiens) 		PF07714
(Pkinase_Tyr) 		6 ALA A 271
MET A 292
THR A 316
LEU A 371
ALA A 381
ASP A 382
 1BM  A 499 (-3.6A)
1BM  A 499 ( 3.8A)
1BM  A 499 (-3.2A)
1BM  A 499 (-4.4A)
1BM  A 499 ( 3.7A)
1BM  A 499 (-4.4A)
 0.83A 4bkjB-2hk5A:
29.3		 4bkjB-2hk5A:
35.22
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2hk5 TYROSINE-PROTEIN
KINASE HCK

(Homo sapiens) 		PF07714
(Pkinase_Tyr) 		6 VAL A 259
ALA A 271
GLU A 288
MET A 292
THR A 316
ASP A 382
 1BM  A 499 ( 4.8A)
1BM  A 499 (-3.6A)
1BM  A 499 (-3.2A)
1BM  A 499 ( 3.8A)
1BM  A 499 (-3.2A)
1BM  A 499 (-4.4A)
 1.06A 4bkjB-2hk5A:
29.3		 4bkjB-2hk5A:
35.22
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2hk5 TYROSINE-PROTEIN
KINASE HCK

(Homo sapiens) 		PF07714
(Pkinase_Tyr) 		6 VAL A 259
ALA A 271
MET A 292
THR A 316
ALA A 381
ASP A 382
 1BM  A 499 ( 4.8A)
1BM  A 499 (-3.6A)
1BM  A 499 ( 3.8A)
1BM  A 499 (-3.2A)
1BM  A 499 ( 3.7A)
1BM  A 499 (-4.4A)
 1.00A 4bkjB-2hk5A:
29.3		 4bkjB-2hk5A:
35.22
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2hz0 PROTO-ONCOGENE
TYROSINE-PROTEIN
KINASE ABL1

(Homo sapiens) 		PF07714
(Pkinase_Tyr) 		7 ALA A 269
GLU A 286
MET A 290
THR A 315
LEU A 370
ALA A 380
ASP A 381
 GIN  A 600 (-3.1A)
GIN  A 600 (-3.6A)
GIN  A 600 (-3.2A)
GIN  A 600 (-3.4A)
GIN  A 600 (-4.7A)
GIN  A 600 (-3.1A)
GIN  A 600 (-4.9A)
 0.63A 4bkjB-2hz0A:
30.2		 4bkjB-2hz0A:
38.05
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2hz0 PROTO-ONCOGENE
TYROSINE-PROTEIN
KINASE ABL1

(Homo sapiens) 		PF07714
(Pkinase_Tyr) 		7 VAL A 256
ALA A 269
GLU A 286
MET A 290
THR A 315
LEU A 370
ALA A 380
 GIN  A 600 ( 4.7A)
GIN  A 600 (-3.1A)
GIN  A 600 (-3.6A)
GIN  A 600 (-3.2A)
GIN  A 600 (-3.4A)
GIN  A 600 (-4.7A)
GIN  A 600 (-3.1A)
 0.67A 4bkjB-2hz0A:
30.2		 4bkjB-2hz0A:
38.05
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2og8 PROTO-ONCOGENE
TYROSINE-PROTEIN
KINASE LCK

(Homo sapiens) 		PF07714
(Pkinase_Tyr) 		9 VAL A 259
ALA A 271
GLU A 288
MET A 292
THR A 316
LEU A 371
ALA A 381
ASP A 382
PHE A 383
 None
1N8  A 501 ( 3.4A)
1N8  A 501 ( 3.6A)
1N8  A 501 ( 3.6A)
1N8  A 501 ( 3.3A)
1N8  A 501 ( 4.3A)
1N8  A 501 ( 3.3A)
1N8  A 501 ( 3.3A)
1N8  A 501 ( 4.3A)
 0.57A 4bkjB-2og8A:
31.4		 4bkjB-2og8A:
37.81
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2ogv MACROPHAGE
COLONY-STIMULATING
FACTOR 1 RECEPTOR
PRECURSOR

(Homo sapiens) 		PF07714
(Pkinase_Tyr) 		6 ALA A 614
GLU A 633
ILE A 636
MET A 637
THR A 663
LEU A 785
 None
 0.94A 4bkjB-2ogvA:
31.6		 4bkjB-2ogvA:
35.47
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2ogv MACROPHAGE
COLONY-STIMULATING
FACTOR 1 RECEPTOR
PRECURSOR

(Homo sapiens) 		PF07714
(Pkinase_Tyr) 		7 VAL A 596
ALA A 614
GLU A 633
ILE A 636
MET A 637
THR A 663
ASP A 796
 None
 0.97A 4bkjB-2ogvA:
31.6		 4bkjB-2ogvA:
35.47
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2p4i ANGIOPOIETIN-1
RECEPTOR

(Homo sapiens) 		PF07714
(Pkinase_Tyr) 		7 VAL A 838
ALA A 853
ILE A 886
LEU A 971
ALA A 981
ASP A 982
PHE A 983
 MR9  A 301 (-4.6A)
MR9  A 301 (-3.5A)
MR9  A 301 (-4.0A)
MR9  A 301 (-4.5A)
MR9  A 301 (-3.2A)
MR9  A 301 (-4.2A)
MR9  A 301 (-4.4A)
 0.55A 4bkjB-2p4iA:
9.1		 4bkjB-2p4iA:
33.52
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2psq FIBROBLAST GROWTH
FACTOR RECEPTOR 2

(Homo sapiens) 		PF07714
(Pkinase_Tyr) 		7 VAL A 495
ALA A 515
GLU A 534
MET A 538
ILE A 548
LEU A 633
ALA A 643
 None
 0.89A 4bkjB-2psqA:
29.7		 4bkjB-2psqA:
33.52
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2qob EPHRIN RECEPTOR

(Homo sapiens) 		PF07714
(Pkinase_Tyr) 		8 VAL A 635
ALA A 651
GLU A 670
ILE A 673
MET A 674
ILE A 683
THR A 699
ASP A 764
 BME  A   1 (-4.9A)
PTR  A 701 ( 4.7A)
None
None
None
None
None
None
 1.06A 4bkjB-2qobA:
24.7		 4bkjB-2qobA:
34.36
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2qob EPHRIN RECEPTOR

(Homo sapiens) 		PF07714
(Pkinase_Tyr) 		7 VAL A 635
ALA A 651
ILE A 673
MET A 674
ILE A 683
THR A 699
LEU A 753
 BME  A   1 (-4.9A)
PTR  A 701 ( 4.7A)
None
None
None
None
None
 1.16A 4bkjB-2qobA:
24.7		 4bkjB-2qobA:
34.36
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2r2p EPHRIN TYPE-A
RECEPTOR 5

(Homo sapiens) 		PF07714
(Pkinase_Tyr)
PF14575
(EphA2_TM) 		8 VAL A 689
ALA A 705
GLU A 724
ILE A 727
MET A 728
ILE A 737
THR A 753
ASP A 818
 None
 0.98A 4bkjB-2r2pA:
30.5		 4bkjB-2r2pA:
35.98
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2r2p EPHRIN TYPE-A
RECEPTOR 5

(Homo sapiens) 		PF07714
(Pkinase_Tyr)
PF14575
(EphA2_TM) 		7 VAL A 689
ALA A 705
ILE A 727
MET A 728
ILE A 737
THR A 753
LEU A 807
 None
 1.01A 4bkjB-2r2pA:
30.5		 4bkjB-2r2pA:
35.98
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2v55 RHO-ASSOCIATED
PROTEIN KINASE 1

(Homo sapiens) 		PF00069
(Pkinase) 		7 VAL A  90
ALA A 103
GLU A 124
ILE A 127
MET A 128
MET A 151
ASP A 216
 None
ANP  A1480 ( 3.9A)
None
None
None
None
ANP  A1480 (-3.5A)
 1.31A 4bkjB-2v55A:
18.5		 4bkjB-2v55A:
23.15
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2v55 RHO-ASSOCIATED
PROTEIN KINASE 1

(Homo sapiens) 		PF00069
(Pkinase) 		7 VAL A  90
ALA A 103
GLU A 124
MET A 128
MET A 151
LEU A 205
ASP A 216
 None
ANP  A1480 ( 3.9A)
None
None
None
ANP  A1480 ( 4.7A)
ANP  A1480 (-3.5A)
 1.18A 4bkjB-2v55A:
18.5		 4bkjB-2v55A:
23.15
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2v55 RHO-ASSOCIATED
PROTEIN KINASE 1

(Homo sapiens) 		PF00069
(Pkinase) 		6 VAL A  90
ALA A 103
MET A 151
LEU A 205
ALA A 215
ASP A 216
 None
ANP  A1480 ( 3.9A)
None
ANP  A1480 ( 4.7A)
ANP  A1480 ( 4.1A)
ANP  A1480 (-3.5A)
 1.07A 4bkjB-2v55A:
18.5		 4bkjB-2v55A:
23.15
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2xyu EPHRIN TYPE-A
RECEPTOR 4,

(Mus musculus) 		PF07714
(Pkinase_Tyr) 		8 VAL A 635
ALA A 651
ILE A 673
MET A 674
ILE A 683
THR A 699
LEU A 753
ASP A 764
 Q9G  A1898 ( 4.7A)
Q9G  A1898 (-3.2A)
None
Q9G  A1898 (-3.9A)
Q9G  A1898 ( 4.9A)
Q9G  A1898 (-3.5A)
Q9G  A1898 (-4.3A)
None
 0.86A 4bkjB-2xyuA:
27.1		 4bkjB-2xyuA:
35.89
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2zmc DUAL SPECIFICITY
PROTEIN KINASE TTK

(Homo sapiens) 		PF00069
(Pkinase) 		6 VAL A 539
ALA A 551
ILE A 586
MET A 600
LEU A 654
ASP A 664
 None
None
None
7PE  A   1 (-3.4A)
None
None
 0.70A 4bkjB-2zmcA:
22.7		 4bkjB-2zmcA:
21.86
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3b2t FIBROBLAST GROWTH
FACTOR RECEPTOR 2

(Homo sapiens) 		PF07714
(Pkinase_Tyr) 		6 VAL A 495
ALA A 515
MET A 538
ILE A 548
LEU A 633
ALA A 643
 M33  A1996 ( 4.7A)
M33  A1996 (-3.3A)
None
None
M33  A1996 (-4.5A)
None
 0.93A 4bkjB-3b2tA:
25.6		 4bkjB-3b2tA:
34.42
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3bhh CALCIUM/CALMODULIN-D
EPENDENT PROTEIN
KINASE TYPE II BETA
CHAIN

(Homo sapiens) 		PF00069
(Pkinase) 		6 VAL A  28
ALA A  41
GLU A  61
ILE A  64
LEU A 143
ALA A 156
 5CP  A 600 ( 4.4A)
5CP  A 600 (-3.6A)
None
None
5CP  A 600 (-4.4A)
5CP  A 600 ( 3.9A)
 0.84A 4bkjB-3bhhA:
22.9		 4bkjB-3bhhA:
25.94
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3c1x HEPATOCYTE GROWTH
FACTOR RECEPTOR

(Homo sapiens) 		PF07714
(Pkinase_Tyr) 		6 ALA A1108
GLU A1127
ILE A1130
MET A1131
ALA A1221
ASP A1222
 CKK  A1500 (-3.2A)
CKK  A1500 (-3.4A)
None
CKK  A1500 (-3.4A)
CKK  A1500 (-3.4A)
CKK  A1500 (-4.5A)
 0.96A 4bkjB-3c1xA:
25.0		 4bkjB-3c1xA:
32.75
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3c1x HEPATOCYTE GROWTH
FACTOR RECEPTOR

(Homo sapiens) 		PF07714
(Pkinase_Tyr) 		6 VAL A1092
ALA A1108
GLU A1127
ILE A1130
MET A1131
ALA A1221
 CKK  A1500 ( 4.3A)
CKK  A1500 (-3.2A)
CKK  A1500 (-3.4A)
None
CKK  A1500 (-3.4A)
CKK  A1500 (-3.4A)
 1.05A 4bkjB-3c1xA:
25.0		 4bkjB-3c1xA:
32.75
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3c4f BASIC FIBROBLAST
GROWTH FACTOR
RECEPTOR 1

(Homo sapiens) 		PF07714
(Pkinase_Tyr) 		7 VAL A 492
ALA A 512
GLU A 531
MET A 535
ILE A 545
LEU A 630
ALA A 640
 None
C4F  A   1 (-3.3A)
None
C4F  A   1 ( 3.7A)
C4F  A   1 ( 4.0A)
C4F  A   1 (-4.6A)
C4F  A   1 (-3.6A)
 0.92A 4bkjB-3c4fA:
29.9		 4bkjB-3c4fA:
37.58
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3c4f BASIC FIBROBLAST
GROWTH FACTOR
RECEPTOR 1

(Homo sapiens) 		PF07714
(Pkinase_Tyr) 		7 VAL A 492
ALA A 512
GLU A 531
MET A 535
LEU A 630
ALA A 640
PHE A 489
 None
C4F  A   1 (-3.3A)
None
C4F  A   1 ( 3.7A)
C4F  A   1 (-4.6A)
C4F  A   1 (-3.6A)
C4F  A   1 (-3.7A)
 0.94A 4bkjB-3c4fA:
29.9		 4bkjB-3c4fA:
37.58
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3dko EPHRIN TYPE-A
RECEPTOR 7

(Homo sapiens) 		PF07714
(Pkinase_Tyr)
PF14575
(EphA2_TM) 		7 VAL A 647
ALA A 663
GLU A 682
ILE A 685
MET A 686
ASP A 776
PHE A 777
 IHZ  A1001 ( 4.4A)
IHZ  A1001 (-3.3A)
IHZ  A1001 (-3.8A)
IHZ  A1001 ( 4.6A)
IHZ  A1001 (-3.5A)
IHZ  A1001 (-4.8A)
IHZ  A1001 (-4.7A)
 0.98A 4bkjB-3dkoA:
30.3		 4bkjB-3dkoA:
34.12
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3dko EPHRIN TYPE-A
RECEPTOR 7

(Homo sapiens) 		PF07714
(Pkinase_Tyr)
PF14575
(EphA2_TM) 		7 VAL A 647
ALA A 663
ILE A 685
MET A 686
LEU A 765
ASP A 776
PHE A 777
 IHZ  A1001 ( 4.4A)
IHZ  A1001 (-3.3A)
IHZ  A1001 ( 4.6A)
IHZ  A1001 (-3.5A)
IHZ  A1001 (-4.6A)
IHZ  A1001 (-4.8A)
IHZ  A1001 (-4.7A)
 1.00A 4bkjB-3dkoA:
30.3		 4bkjB-3dkoA:
34.12
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3eb0 PUTATIVE
UNCHARACTERIZED
PROTEIN

(Cryptosporidium
parvum) 		PF00069
(Pkinase) 		7 VAL A  23
ALA A  36
GLU A  50
ILE A  53
MET A  54
ILE A  63
LEU A 173
 None
DRK  A 384 (-3.5A)
None
None
None
DRK  A 384 ( 4.5A)
DRK  A 384 (-4.4A)
 0.78A 4bkjB-3eb0A:
20.9		 4bkjB-3eb0A:
24.57
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3gp0 MITOGEN-ACTIVATED
PROTEIN KINASE 11

(Homo sapiens) 		PF00069
(Pkinase) 		6 VAL A  38
ALA A  51
GLU A  71
ILE A  84
THR A 106
ASP A 168
 NIL  A   1 ( 4.7A)
NIL  A   1 (-3.7A)
NIL  A   1 (-3.7A)
NIL  A   1 (-4.4A)
NIL  A   1 (-3.3A)
NIL  A   1 (-4.6A)
 0.47A 4bkjB-3gp0A:
22.2		 4bkjB-3gp0A:
25.74
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3hng VASCULAR ENDOTHELIAL
GROWTH FACTOR
RECEPTOR 1

(Homo sapiens) 		PF07714
(Pkinase_Tyr) 		6 VAL A 841
ALA A 859
GLU A 878
ILE A 881
LEU A1029
ASP A1040
 8ST  A2001 ( 4.6A)
8ST  A2001 ( 3.8A)
8ST  A2001 (-3.7A)
None
None
None
 0.73A 4bkjB-3hngA:
32.7		 4bkjB-3hngA:
30.08
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3iec SERINE/THREONINE-PRO
TEIN KINASE MARK2

(Homo sapiens) 		PF00069
(Pkinase)
PF00627
(UBA) 		6 ALA A  80
ILE A 103
MET A 104
LEU A 182
ALA A 192
ASP A 193
 None
 1.02A 4bkjB-3iecA:
21.9		 4bkjB-3iecA:
26.43
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3iec SERINE/THREONINE-PRO
TEIN KINASE MARK2

(Homo sapiens) 		PF00069
(Pkinase)
PF00627
(UBA) 		6 GLU A 100
ILE A 103
MET A 104
LEU A 182
ALA A 192
ASP A 193
 None
 1.06A 4bkjB-3iecA:
21.9		 4bkjB-3iecA:
26.43
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3iec SERINE/THREONINE-PRO
TEIN KINASE MARK2

(Homo sapiens) 		PF00069
(Pkinase)
PF00627
(UBA) 		6 VAL A  67
ALA A  80
MET A 104
LEU A 182
ALA A 192
ASP A 193
 None
 0.89A 4bkjB-3iecA:
21.9		 4bkjB-3iecA:
26.43
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3kul EPHRIN TYPE-A
RECEPTOR 8

(Homo sapiens) 		PF07714
(Pkinase_Tyr)
PF14575
(EphA2_TM) 		7 ALA A 665
GLU A 684
ILE A 687
MET A 688
ILE A 697
THR A 713
LEU A 767
 None
 0.76A 4bkjB-3kulA:
27.1		 4bkjB-3kulA:
37.18
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3kul EPHRIN TYPE-A
RECEPTOR 8

(Homo sapiens) 		PF07714
(Pkinase_Tyr)
PF14575
(EphA2_TM) 		7 VAL A 649
ALA A 665
GLU A 684
MET A 688
ILE A 697
THR A 713
LEU A 767
 None
 0.81A 4bkjB-3kulA:
27.1		 4bkjB-3kulA:
37.18
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3mdy BONE MORPHOGENETIC
PROTEIN RECEPTOR
TYPE-1B

(Homo sapiens) 		PF07714
(Pkinase_Tyr)
PF08515
(TGF_beta_GS) 		6 VAL A 218
ALA A 229
GLU A 244
ILE A 247
THR A 279
LEU A 339
 LDN  A   1 ( 4.8A)
LDN  A   1 (-3.6A)
None
None
LDN  A   1 (-3.8A)
LDN  A   1 (-4.5A)
 0.89A 4bkjB-3mdyA:
24.2		 4bkjB-3mdyA:
24.79
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3mdy BONE MORPHOGENETIC
PROTEIN RECEPTOR
TYPE-1B

(Homo sapiens) 		PF07714
(Pkinase_Tyr)
PF08515
(TGF_beta_GS) 		6 VAL A 218
ALA A 229
ILE A 247
THR A 279
LEU A 339
ALA A 349
 LDN  A   1 ( 4.8A)
LDN  A   1 (-3.6A)
None
LDN  A   1 (-3.8A)
LDN  A   1 (-4.5A)
LDN  A   1 ( 3.8A)
 1.02A 4bkjB-3mdyA:
24.2		 4bkjB-3mdyA:
24.79
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3mvj CAMP-DEPENDENT
PROTEIN KINASE
CATALYTIC SUBUNIT
ALPHA

(Homo sapiens) 		PF00069
(Pkinase) 		6 VAL A  57
ALA A  70
GLU A  91
ILE A  94
MET A 118
LEU A 173
 XFE  A 351 ( 4.5A)
XFE  A 351 (-3.2A)
None
None
None
XFE  A 351 (-4.6A)
 1.01A 4bkjB-3mvjA:
21.2		 4bkjB-3mvjA:
24.93
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3my0 SERINE/THREONINE-PRO
TEIN KINASE RECEPTOR
R3

(Homo sapiens) 		PF07714
(Pkinase_Tyr) 		7 VAL A 216
ALA A 227
ILE A 245
THR A 277
LEU A 337
ALA A 347
ASP A 348
 LDN  A 600 (-4.5A)
LDN  A 600 (-3.2A)
None
LDN  A 600 (-4.0A)
LDN  A 600 (-4.6A)
LDN  A 600 ( 3.8A)
None
 1.22A 4bkjB-3my0A:
24.1		 4bkjB-3my0A:
27.30
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3ppz SERINE/THREONINE-PRO
TEIN KINASE CTR1

(Arabidopsis
thaliana) 		PF07714
(Pkinase_Tyr) 		6 ALA A 576
GLU A 596
ILE A 599
MET A 600
THR A 625
LEU A 683
 STU  A   1 (-3.3A)
None
None
None
STU  A   1 (-4.1A)
STU  A   1 (-4.3A)
 0.68A 4bkjB-3ppzA:
27.6		 4bkjB-3ppzA:
31.93
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3tt0 BASIC FIBROBLAST
GROWTH FACTOR
RECEPTOR 1

(Homo sapiens) 		PF07714
(Pkinase_Tyr) 		7 VAL A 492
ALA A 512
GLU A 531
MET A 535
ILE A 545
LEU A 630
ALA A 640
 07J  A   1 (-4.0A)
07J  A   1 (-3.5A)
07J  A   1 (-3.8A)
07J  A   1 (-3.8A)
07J  A   1 (-3.8A)
07J  A   1 ( 4.4A)
07J  A   1 (-3.2A)
 0.91A 4bkjB-3tt0A:
30.1		 4bkjB-3tt0A:
31.06
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3v5q NT-3 GROWTH FACTOR
RECEPTOR

(Homo sapiens) 		PF07714
(Pkinase_Tyr) 		6 ALA A 570
GLU A 588
MET A 615
LEU A 686
ASP A 697
PHE A 698
 0F4  A 902 (-3.2A)
0F4  A 902 (-3.6A)
None
0F4  A 902 (-4.5A)
None
0F4  A 902 (-4.1A)
 0.87A 4bkjB-3v5qA:
29.4		 4bkjB-3v5qA:
45.57
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3v5q NT-3 GROWTH FACTOR
RECEPTOR

(Homo sapiens) 		PF07714
(Pkinase_Tyr) 		6 VAL A 552
ALA A 570
MET A 615
LEU A 686
ASP A 697
PHE A 698
 None
0F4  A 902 (-3.2A)
None
0F4  A 902 (-4.5A)
None
0F4  A 902 (-4.1A)
 1.00A 4bkjB-3v5qA:
29.4		 4bkjB-3v5qA:
45.57
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3vid VASCULAR ENDOTHELIAL
GROWTH FACTOR
RECEPTOR 2

(Homo sapiens) 		PF07714
(Pkinase_Tyr) 		6 VAL A 848
ALA A 866
GLU A 885
ILE A 888
LEU A1035
ASP A1046
 4TT  A2001 ( 4.5A)
4TT  A2001 (-3.5A)
None
None
4TT  A2001 (-4.8A)
None
 0.96A 4bkjB-3vidA:
30.2		 4bkjB-3vidA:
31.02
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3zfx EPHRIN TYPE-B
RECEPTOR 1

(Homo sapiens) 		PF07714
(Pkinase_Tyr) 		7 VAL A 633
ALA A 649
GLU A 668
ILE A 671
MET A 672
ILE A 681
THR A 697
 None
 0.95A 4bkjB-3zfxA:
30.6		 4bkjB-3zfxA:
37.16
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3zfx EPHRIN TYPE-B
RECEPTOR 1

(Homo sapiens) 		PF07714
(Pkinase_Tyr) 		7 VAL A 633
ALA A 649
ILE A 671
MET A 672
ILE A 681
THR A 697
LEU A 751
 None
 1.16A 4bkjB-3zfxA:
30.6		 4bkjB-3zfxA:
37.16
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4agd VASCULAR ENDOTHELIAL
GROWTH FACTOR
RECEPTOR 2

(Homo sapiens) 		PF07714
(Pkinase_Tyr) 		6 VAL A 848
ALA A 866
GLU A 885
ILE A 888
LEU A1035
ASP A1046
 None
B49  A2000 (-3.5A)
None
None
B49  A2000 (-4.5A)
None
 0.97A 4bkjB-4agdA:
32.0		 4bkjB-4agdA:
30.11
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4aw5 EPHRIN TYPE-B
RECEPTOR 4

(Homo sapiens) 		PF07714
(Pkinase_Tyr) 		6 VAL A 105
ALA A 121
GLU A 140
ILE A 143
MET A 144
ILE A 153
 30K  A1365 ( 4.6A)
30K  A1365 (-3.2A)
None
None
None
None
 0.91A 4bkjB-4aw5A:
26.9		 4bkjB-4aw5A:
37.54
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4aw5 EPHRIN TYPE-B
RECEPTOR 4

(Homo sapiens) 		PF07714
(Pkinase_Tyr) 		7 VAL A 105
ALA A 121
ILE A 143
MET A 144
ILE A 153
THR A 169
LEU A 223
 30K  A1365 ( 4.6A)
30K  A1365 (-3.2A)
None
None
None
30K  A1365 (-3.8A)
30K  A1365 (-4.5A)
 1.12A 4bkjB-4aw5A:
26.9		 4bkjB-4aw5A:
37.54
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4bc6 SERINE/THREONINE-PRO
TEIN KINASE 10

(Homo sapiens) 		PF00069
(Pkinase) 		6 VAL A  50
ALA A  63
GLU A  81
ILE A  84
LEU A 164
ALA A 174
 XZN  A1317 ( 4.7A)
XZN  A1317 (-3.5A)
XZN  A1317 (-3.9A)
None
XZN  A1317 (-4.7A)
XZN  A1317 ( 4.3A)
 0.83A 4bkjB-4bc6A:
20.6		 4bkjB-4bc6A:
26.67
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4cfh 5'-AMP-ACTIVATED
PROTEIN KINASE
CATALYTIC SUBUNIT
ALPHA-1

(Rattus
norvegicus) 		PF00069
(Pkinase)
PF16579
(AdenylateSensor) 		6 VAL A  30
ALA A  43
GLU A  64
MET A  91
LEU A 146
ALA A 156
 None
STU  A1550 (-3.1A)
None
None
STU  A1550 (-4.3A)
STU  A1550 ( 3.8A)
 1.06A 4bkjB-4cfhA:
22.4		 4bkjB-4cfhA:
21.79
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4ckr EPITHELIAL DISCOIDIN
DOMAIN-CONTAINING
RECEPTOR 1

(Homo sapiens) 		PF07714
(Pkinase_Tyr) 		12 VAL A 624
ALA A 653
GLU A 672
ILE A 675
MET A 676
ILE A 685
MET A 699
THR A 701
LEU A 773
ALA A 783
ASP A 784
PHE A 785
 DI1  A1000 (-4.8A)
DI1  A1000 (-3.6A)
DI1  A1000 (-3.8A)
None
DI1  A1000 (-3.6A)
DI1  A1000 (-4.5A)
DI1  A1000 ( 4.1A)
DI1  A1000 (-3.6A)
DI1  A1000 (-4.5A)
DI1  A1000 (-3.7A)
DI1  A1000 (-4.1A)
DI1  A1000 (-4.5A)
 0.58A 4bkjB-4ckrA:
45.8		 4bkjB-4ckrA:
100.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4f0g SERINE/THREONINE-PRO
TEIN KINASE ROCO4

(Dictyostelium
discoideum) 		PF07714
(Pkinase_Tyr) 		6 VAL A1040
ALA A1053
GLU A1078
ILE A1081
MET A1103
ALA A1176
 None
 0.59A 4bkjB-4f0gA:
19.5		 4bkjB-4f0gA:
29.85
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4fr4 SERINE/THREONINE-PRO
TEIN KINASE 32A

(Homo sapiens) 		PF00069
(Pkinase) 		6 VAL A  37
ALA A  50
GLU A  71
ILE A  74
MET A  98
LEU A 153
 STU  A 401 ( 4.9A)
STU  A 401 (-3.2A)
None
None
None
STU  A 401 (-4.7A)
 0.95A 4bkjB-4fr4A:
20.6		 4bkjB-4fr4A:
23.41
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4hvi TYROSINE-PROTEIN
KINASE JAK3

(Homo sapiens) 		PF07714
(Pkinase_Tyr) 		6 VAL A 836
ALA A 853
GLU A 871
ILE A 874
LEU A 956
ALA A 966
 19S  A1201 (-4.4A)
19S  A1201 (-3.3A)
None
None
19S  A1201 (-4.5A)
19S  A1201 ( 4.1A)
 0.77A 4bkjB-4hviA:
23.1		 4bkjB-4hviA:
33.33
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4id7 ACTIVATED CDC42
KINASE 1

(Homo sapiens) 		PF07714
(Pkinase_Tyr) 		7 VAL A 140
ALA A 156
ILE A 190
MET A 203
THR A 205
LEU A 259
ASP A 270
 1G0  A 401 (-4.4A)
1G0  A 401 (-3.6A)
1G0  A 401 (-4.3A)
1G0  A 401 ( 3.7A)
1G0  A 401 (-3.2A)
1G0  A 401 (-4.6A)
None
 1.22A 4bkjB-4id7A:
28.4		 4bkjB-4id7A:
36.99
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4k33 FIBROBLAST GROWTH
FACTOR RECEPTOR 3

(Homo sapiens) 		PF07714
(Pkinase_Tyr) 		6 ALA A 506
GLU A 525
MET A 529
ILE A 539
LEU A 624
ALA A 634
 ACP  A 801 (-3.3A)
ACP  A 801 ( 4.8A)
None
None
ACP  A 801 (-4.4A)
None
 0.88A 4bkjB-4k33A:
26.9		 4bkjB-4k33A:
34.69
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4k33 FIBROBLAST GROWTH
FACTOR RECEPTOR 3

(Homo sapiens) 		PF07714
(Pkinase_Tyr) 		6 VAL A 486
ALA A 506
GLU A 525
MET A 529
ILE A 539
ALA A 634
 ACP  A 801 (-4.2A)
ACP  A 801 (-3.3A)
ACP  A 801 ( 4.8A)
None
None
None
 0.75A 4bkjB-4k33A:
26.9		 4bkjB-4k33A:
34.69
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4lg4 SERINE/THREONINE-PRO
TEIN KINASE 3

(Homo sapiens) 		PF00069
(Pkinase) 		6 VAL A  41
ALA A  54
GLU A  70
ILE A  73
MET A  74
ALA A 163
 GOL  A 404 (-4.5A)
GOL  A 404 ( 3.1A)
None
None
None
GOL  A 403 ( 3.0A)
 0.92A 4bkjB-4lg4A:
18.9		 4bkjB-4lg4A:
23.30
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4o27 SERINE/THREONINE-PRO
TEIN KINASE 24

(Homo sapiens) 		PF00069
(Pkinase) 		6 VAL B  38
ALA B  51
GLU B  70
LEU B 151
ALA B 161
ASP B 162
 ADP  B 500 (-4.5A)
ADP  B 500 (-3.3A)
None
ADP  B 500 (-4.7A)
None
ADP  B 500 ( 3.4A)
 0.96A 4bkjB-4o27B:
19.4		 4bkjB-4o27B:
26.50
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4o38 CYCLIN-G-ASSOCIATED
KINASE

(Homo sapiens) 		PF00069
(Pkinase) 		6 ALA A  67
GLU A  85
MET A  89
THR A 123
LEU A 180
ASP A 191
 SIN  A 401 ( 3.7A)
None
None
None
SIN  A 401 ( 4.5A)
None
 0.93A 4bkjB-4o38A:
19.8		 4bkjB-4o38A:
25.56
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4o38 CYCLIN-G-ASSOCIATED
KINASE

(Homo sapiens) 		PF00069
(Pkinase) 		6 VAL A  54
ALA A  67
GLU A  85
MET A  89
THR A 123
LEU A 180
 None
SIN  A 401 ( 3.7A)
None
None
None
SIN  A 401 ( 4.5A)
 0.96A 4bkjB-4o38A:
19.8		 4bkjB-4o38A:
25.56
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4rew 5'-AMP-ACTIVATED
PROTEIN KINASE
CATALYTIC SUBUNIT
ALPHA-1

(Homo sapiens) 		PF00069
(Pkinase)
PF16579
(AdenylateSensor) 		6 VAL A  32
ALA A  45
ILE A  79
MET A  93
LEU A 148
ALA A 158
 STU  A 601 ( 4.8A)
STU  A 601 (-3.2A)
STU  A 601 ( 4.6A)
None
STU  A 601 (-4.2A)
STU  A 601 ( 3.8A)
 1.00A 4bkjB-4rewA:
22.3		 4bkjB-4rewA:
19.86
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4rt7 RECEPTOR-TYPE
TYROSINE-PROTEIN
KINASE FLT3

(Homo sapiens) 		PF07714
(Pkinase_Tyr) 		6 VAL A 624
ALA A 642
GLU A 661
LEU A 818
ASP A 829
PHE A 830
 None
P30  A1001 (-3.4A)
P30  A1001 (-3.6A)
P30  A1001 (-4.6A)
None
P30  A1001 (-3.9A)
 0.99A 4bkjB-4rt7A:
29.0		 4bkjB-4rt7A:
28.10
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4ueu TYROSINE KINASE AS -
A COMMON ANCESTOR OF
SRC AND ABL

(synthetic
construct) 		PF07714
(Pkinase_Tyr) 		7 VAL A  22
ALA A  35
GLU A  52
ILE A  55
MET A  56
THR A  81
ASP A 147
 ACP  A1264 (-4.7A)
ACP  A1264 (-2.9A)
None
None
None
ACP  A1264 (-4.5A)
None
 1.11A 4bkjB-4ueuA:
29.8		 4bkjB-4ueuA:
39.81
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4ueu TYROSINE KINASE AS -
A COMMON ANCESTOR OF
SRC AND ABL

(synthetic
construct) 		PF07714
(Pkinase_Tyr) 		8 VAL A  22
ALA A  35
ILE A  55
MET A  56
THR A  81
LEU A 136
ALA A 146
ASP A 147
 ACP  A1264 (-4.7A)
ACP  A1264 (-2.9A)
None
None
ACP  A1264 (-4.5A)
ACP  A1264 ( 4.8A)
None
None
 1.11A 4bkjB-4ueuA:
29.8		 4bkjB-4ueuA:
39.81
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4wsq AP2-ASSOCIATED
PROTEIN KINASE 1

(Homo sapiens) 		PF00069
(Pkinase) 		6 ALA A  72
GLU A  90
ILE A  93
MET A  94
LEU A 183
ASP A 194
 KSA  A 405 (-3.2A)
None
None
None
KSA  A 405 (-4.6A)
ZN  A 403 ( 2.6A)
 0.98A 4bkjB-4wsqA:
22.0		 4bkjB-4wsqA:
23.28
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4wsq AP2-ASSOCIATED
PROTEIN KINASE 1

(Homo sapiens) 		PF00069
(Pkinase) 		6 VAL A  60
ALA A  72
GLU A  90
ILE A  93
MET A  94
LEU A 183
 KSA  A 405 ( 4.9A)
KSA  A 405 (-3.2A)
None
None
None
KSA  A 405 (-4.6A)
 0.94A 4bkjB-4wsqA:
22.0		 4bkjB-4wsqA:
23.28
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4xcu FIBROBLAST GROWTH
FACTOR RECEPTOR 4

(Homo sapiens) 		PF07714
(Pkinase_Tyr) 		7 VAL A 481
ALA A 501
GLU A 520
MET A 524
ILE A 534
LEU A 619
ALA A 629
 40M  A1002 ( 4.5A)
40M  A1002 ( 4.1A)
40M  A1002 (-3.7A)
40M  A1002 (-3.8A)
40M  A1002 (-4.0A)
40M  A1002 (-4.5A)
40M  A1002 (-3.0A)
 0.86A 4bkjB-4xcuA:
29.6		 4bkjB-4xcuA:
38.08
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4xey TYROSINE-PROTEIN
KINASE ABL1

(Homo sapiens) 		no annotation 6 VAL B 275
ALA B 288
MET B 309
THR B 334
LEU B 389
ALA B 399
 1N1  B 601 ( 4.9A)
1N1  B 601 (-3.5A)
1N1  B 601 (-3.7A)
1N1  B 601 (-3.3A)
1N1  B 601 (-4.3A)
1N1  B 601 (-3.5A)
 0.88A 4bkjB-4xeyB:
30.1		 4bkjB-4xeyB:
29.67
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4xuf RECEPTOR-TYPE
TYROSINE-PROTEIN
KINASE FLT3

(Homo sapiens) 		PF07714
(Pkinase_Tyr) 		6 VAL A 624
ALA A 642
GLU A 661
LEU A 818
ASP A 829
PHE A 830
 P30  A1001 ( 4.8A)
P30  A1001 (-3.5A)
P30  A1001 (-3.1A)
P30  A1001 (-4.3A)
None
P30  A1001 ( 4.1A)
 1.03A 4bkjB-4xufA:
25.1		 4bkjB-4xufA:
33.44
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4yff SERINE/THREONINE-PRO
TEIN KINASE TNNI3K

(Homo sapiens) 		PF07714
(Pkinase_Tyr) 		8 VAL A 477
ALA A 488
GLU A 509
ILE A 512
ILE A 522
THR A 539
LEU A 595
ALA A 605
 None
4CV  A 801 (-3.5A)
None
None
4CV  A 801 ( 4.2A)
4CV  A 801 (-2.8A)
4CV  A 801 (-4.4A)
4CV  A 801 ( 3.9A)
 0.78A 4bkjB-4yffA:
24.4		 4bkjB-4yffA:
29.55
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5a46 FIBROBLAST GROWTH
FACTOR RECEPTOR 1
(FMS-RELATED
TYROSINE KINASE 2,
PFEIFFER SYNDROME),
ISOFORM CRA_B

(Homo sapiens) 		PF07714
(Pkinase_Tyr) 		7 VAL A 492
ALA A 512
GLU A 531
MET A 535
ILE A 545
LEU A 630
ALA A 640
 38O  A1769 (-4.5A)
38O  A1769 (-3.6A)
EDO  A1766 (-4.1A)
EDO  A1766 (-3.5A)
38O  A1769 ( 3.3A)
38O  A1769 (-4.6A)
EDO  A1766 ( 4.4A)
 0.96A 4bkjB-5a46A:
30.4		 4bkjB-5a46A:
31.82
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5e8y TGF-BETA RECEPTOR
TYPE-2

(Homo sapiens) 		PF07714
(Pkinase_Tyr) 		6 VAL A 258
ALA A 275
GLU A 290
ILE A 293
THR A 325
LEU A 386
 STU  A 601 (-4.0A)
STU  A 601 (-3.1A)
STU  A 601 ( 3.8A)
None
STU  A 601 ( 3.7A)
STU  A 601 (-3.9A)
 0.99A 4bkjB-5e8yA:
23.8		 4bkjB-5e8yA:
26.42
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ezr CGMP-DEPENDENT
PROTEIN KINASE,
PUTATIVE

(Plasmodium
vivax) 		PF00027
(cNMP_binding)
PF00069
(Pkinase) 		6 VAL A 548
ALA A 561
ILE A 595
THR A 611
LEU A 664
ASP A 675
 4ZS  A 901 (-4.8A)
4ZS  A 901 ( 3.8A)
4ZS  A 901 (-4.3A)
4ZS  A 901 (-3.2A)
4ZS  A 901 (-3.6A)
None
 1.03A 4bkjB-5ezrA:
19.5		 4bkjB-5ezrA:
17.51
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5f1z NON-RECEPTOR
TYROSINE-PROTEIN
KINASE TYK2

(Homo sapiens) 		PF07714
(Pkinase_Tyr) 		6 VAL A 911
ALA A 928
GLU A 947
ILE A 950
ILE A 960
LEU A1030
 5U3  A1200 ( 4.4A)
5U3  A1200 (-3.5A)
None
None
5U3  A1200 (-4.6A)
5U3  A1200 (-4.4A)
 0.93A 4bkjB-5f1zA:
27.4		 4bkjB-5f1zA:
34.14
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5grn PLATELET-DERIVED
GROWTH FACTOR
RECEPTOR ALPHA

(Homo sapiens) 		PF07714
(Pkinase_Tyr) 		8 VAL A 607
ALA A 625
GLU A 644
ILE A 647
MET A 648
THR A 674
LEU A 825
ASP A 836
 748  A1001 ( 4.7A)
748  A1001 (-3.7A)
748  A1001 (-3.3A)
748  A1001 ( 4.0A)
748  A1001 (-3.4A)
748  A1001 (-3.2A)
748  A1001 (-4.3A)
748  A1001 (-4.8A)
 0.78A 4bkjB-5grnA:
26.9		 4bkjB-5grnA:
30.59
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5i3o BMP-2-INDUCIBLE
PROTEIN KINASE

(Homo sapiens) 		PF00069
(Pkinase) 		6 VAL A  65
ALA A  77
GLU A  95
ILE A  98
MET A  99
LEU A 187
 IDV  A 401 (-4.6A)
IDV  A 401 (-3.6A)
None
None
None
IDV  A 401 (-4.4A)
 0.89A 4bkjB-5i3oA:
21.8		 4bkjB-5i3oA:
26.33
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5idn CYCLIN-DEPENDENT
KINASE 8

(Homo sapiens) 		PF00069
(Pkinase) 		6 VAL A  35
ALA A  50
ILE A  79
LEU A 158
ALA A 172
ASP A 173
 6A7  A 401 ( 4.5A)
6A7  A 401 (-3.3A)
6A7  A 401 (-4.2A)
6A7  A 401 (-4.8A)
6A7  A 401 ( 4.1A)
FMT  A 403 ( 3.3A)
 0.87A 4bkjB-5idnA:
20.6		 4bkjB-5idnA:
26.58
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5j5t MITOGEN-ACTIVATED
PROTEIN KINASE
KINASE KINASE KINASE
3

(Homo sapiens) 		PF00069
(Pkinase) 		6 VAL A  30
ALA A  43
GLU A  61
MET A  65
LEU A 143
ALA A 153
 6G2  A 901 ( 4.9A)
6G2  A 901 (-3.2A)
None
None
6G2  A 901 (-4.7A)
6G2  A 901 ( 4.2A)
 0.81A 4bkjB-5j5tA:
20.8		 4bkjB-5j5tA:
23.21
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5l6o EPHRIN TYPE-B
RECEPTOR 3

(Homo sapiens) 		PF07714
(Pkinase_Tyr) 		8 VAL A 647
ALA A 663
ILE A 685
MET A 686
ILE A 695
THR A 711
LEU A 765
ASP A 776
 None
6P6  A1001 (-3.3A)
None
6P6  A1001 ( 4.2A)
None
6P6  A1001 (-3.5A)
6P6  A1001 (-4.5A)
None
 0.92A 4bkjB-5l6oA:
31.7		 4bkjB-5l6oA:
37.20
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5lxd DUAL SPECIFICITY
TYROSINE-PHOSPHORYLA
TION-REGULATED
KINASE 2

(Homo sapiens) 		PF00069
(Pkinase) 		6 VAL A 163
ALA A 176
GLU A 193
ILE A 196
ILE A 212
LEU A 282
 7A7  A 501 (-4.4A)
7A7  A 501 (-3.5A)
7A7  A 501 ( 4.7A)
None
7A7  A 501 (-4.8A)
7A7  A 501 (-4.9A)
 0.97A 4bkjB-5lxdA:
20.0		 4bkjB-5lxdA:
23.47
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5lxd DUAL SPECIFICITY
TYROSINE-PHOSPHORYLA
TION-REGULATED
KINASE 2

(Homo sapiens) 		PF00069
(Pkinase) 		6 VAL A 163
ALA A 176
GLU A 193
ILE A 212
MET A 226
LEU A 282
 7A7  A 501 (-4.4A)
7A7  A 501 (-3.5A)
7A7  A 501 ( 4.7A)
7A7  A 501 (-4.8A)
None
7A7  A 501 (-4.9A)
 0.95A 4bkjB-5lxdA:
20.0		 4bkjB-5lxdA:
23.47
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5u7q RHO-ASSOCIATED
PROTEIN KINASE 2

(Homo sapiens) 		PF00069
(Pkinase) 		6 VAL A 106
ALA A 119
GLU A 140
ILE A 143
MET A 144
MET A 167
 None
 0.90A 4bkjB-5u7qA:
19.4		 4bkjB-5u7qA:
22.68
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5y86 DUAL SPECIFICITY
TYROSINE-PHOSPHORYLA
TION-REGULATED
KINASE 3

(Homo sapiens) 		no annotation 7 ALA A 236
GLU A 253
ILE A 256
ILE A 272
MET A 286
LEU A 342
ASP A 355
 HRM  A 601 (-3.5A)
HRM  A 601 ( 4.6A)
None
HRM  A 601 ( 4.8A)
None
None
HRM  A 601 (-4.7A)
 1.16A 4bkjB-5y86A:
19.8		 4bkjB-5y86A:
12.90
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5y86 DUAL SPECIFICITY
TYROSINE-PHOSPHORYLA
TION-REGULATED
KINASE 3

(Homo sapiens) 		no annotation 7 VAL A 223
ALA A 236
GLU A 253
ILE A 256
ILE A 272
MET A 286
LEU A 342
 HRM  A 601 ( 4.9A)
HRM  A 601 (-3.5A)
HRM  A 601 ( 4.6A)
None
HRM  A 601 ( 4.8A)
None
None
 0.90A 4bkjB-5y86A:
19.8		 4bkjB-5y86A:
12.90
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6b3e CYCLIN-DEPENDENT
KINASE 12

(Homo sapiens) 		no annotation 6 VAL A 741
ALA A 754
GLU A 774
ILE A 777
LEU A 866
ALA A 876
 None
CJM  A1102 (-3.1A)
None
None
CJM  A1102 (-4.4A)
CJM  A1102 (-3.6A)
 0.62A 4bkjB-6b3eA:
22.6		 4bkjB-6b3eA:
15.04
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6b4w DUAL SPECIFICITY
PROTEIN KINASE TTK

(Homo sapiens) 		no annotation 6 VAL A 539
ALA A 551
ILE A 586
MET A 600
LEU A 654
ASP A 664
 CQ7  A 801 ( 4.8A)
CQ7  A 801 (-3.2A)
CQ7  A 801 ( 4.5A)
None
CQ7  A 801 (-4.5A)
None
 0.75A 4bkjB-6b4wA:
23.4		 4bkjB-6b4wA:
22.65
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6bql CALCIUM/CALMODULIN-D
EPENDENT PROTEIN
KINASE KINASE 2

(Homo sapiens) 		no annotation 6 VAL A 179
ALA A 192
MET A 265
LEU A 319
ALA A 329
ASP A 330
 BI9  A 501 ( 4.8A)
BI9  A 501 (-3.3A)
None
BI9  A 501 (-4.7A)
NH4  A 506 ( 3.7A)
None
 0.88A 4bkjB-6bqlA:
21.4		 4bkjB-6bqlA:
14.15
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6bx6 5'-AMP-ACTIVATED
PROTEIN KINASE
CATALYTIC SUBUNIT
ALPHA-2

(Homo sapiens) 		no annotation 6 VAL A  30
ALA A  43
ILE A  77
MET A  91
LEU A 146
ALA A 156
 None
EDJ  A 301 (-3.4A)
EDJ  A 301 ( 4.7A)
None
EDJ  A 301 ( 4.5A)
EDJ  A 301 (-3.2A)
 1.07A 4bkjB-6bx6A:
18.6		 4bkjB-6bx6A:
16.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6c9d SERINE/THREONINE-PRO
TEIN KINASE
MARK1,SERINE/THREONI
NE-PROTEIN KINASE
MARK1

(Homo sapiens) 		no annotation 7 VAL A  74
ALA A  87
GLU A 107
ILE A 110
MET A 111
LEU A 189
ALA A 199
 None
 1.14A 4bkjB-6c9dA:
21.1		 4bkjB-6c9dA:
11.78
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1k2p TYROSINE-PROTEIN
KINASE BTK

(Homo sapiens) 		PF07714
(Pkinase_Tyr) 		4 LYS A 430
LEU A 452
TYR A 476
MET A 477
 None
 1.28A 4bkjB-1k2pA:
23.4		 4bkjB-1k2pA:
29.84
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1k9a CARBOXYL-TERMINAL
SRC KINASE

(Rattus
norvegicus) 		PF00017
(SH2)
PF00018
(SH3_1)
PF07714
(Pkinase_Tyr) 		5 LYS A 222
LEU A 243
TYR A 268
MET A 269
ARG A 313
 None
 1.29A 4bkjB-1k9aA:
28.6		 4bkjB-1k9aA:
25.05
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1luf MUSCLE-SPECIFIC
TYROSINE KINASE
RECEPTOR MUSK

(Rattus
norvegicus) 		PF07714
(Pkinase_Tyr) 		4 LYS A 608
TYR A 656
MET A 657
ARG A 723
 None
 0.89A 4bkjB-1lufA:
36.1		 4bkjB-1lufA:
39.20
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1t46 HOMO SAPIENS V-KIT
HARDY-ZUCKERMAN 4
FELINE SARCOMA VIRAL
ONCOGENE HOMOLOG

(Homo sapiens) 		PF07714
(Pkinase_Tyr) 		4 LYS A 623
LEU A 647
TYR A 672
ARG A 791
 STI  A   3 (-3.7A)
None
STI  A   3 ( 4.0A)
None
 1.04A 4bkjB-1t46A:
33.7		 4bkjB-1t46A:
32.84
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1u5q SERINE/THREONINE
PROTEIN KINASE TAO2

(Rattus
norvegicus) 		PF00069
(Pkinase) 		4 LYS A  57
LEU A  83
TYR A 107
ARG A 150
 None
None
None
SEP  A 181 ( 2.8A)
 0.90A 4bkjB-1u5qA:
23.5		 4bkjB-1u5qA:
26.95
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1xng NH(3)-DEPENDENT
NAD(+) SYNTHETASE

(Helicobacter
pylori) 		PF02540
(NAD_synthase) 		4 LYS A  77
LEU A  44
TYR A  82
ARG A 169
 None
 1.33A 4bkjB-1xngA:
undetectable		 4bkjB-1xngA:
20.47
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1zlt SERINE/THREONINE-PRO
TEIN KINASE CHK1

(Homo sapiens) 		PF00069
(Pkinase) 		4 LYS A  38
LEU A  62
TYR A  86
ARG A 129
 HYM  A 400 (-3.2A)
None
HYM  A 400 (-4.7A)
SO4  A 901 (-2.9A)
 1.17A 4bkjB-1zltA:
20.2		 4bkjB-1zltA:
24.11
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2bd0 SEPIAPTERIN
REDUCTASE

(Chlorobaculum
tepidum) 		PF00106
(adh_short) 		4 LEU A   6
TYR A 175
MET A 172
ARG A  75
 None
 1.47A 4bkjB-2bd0A:
undetectable		 4bkjB-2bd0A:
21.89
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2dq7 PROTO-ONCOGENE
TYROSINE-PROTEIN
KINASE FYN

(Homo sapiens) 		PF07714
(Pkinase_Tyr) 		5 LYS X  39
LEU X  61
TYR X  84
MET X  85
ARG X 129
 STU  X 902 (-3.1A)
None
STU  X 902 (-4.6A)
None
PTR  X 160 ( 3.4A)
 1.17A 4bkjB-2dq7X:
29.9		 4bkjB-2dq7X:
35.24
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2gcd SERINE/THREONINE-PRO
TEIN KINASE TAO2

(Rattus
norvegicus) 		PF00069
(Pkinase) 		4 LYS A  57
LEU A  83
TYR A 107
ARG A 150
 STU  A 400 ( 4.5A)
None
STU  A 400 (-4.5A)
SEP  A 181 ( 2.9A)
 1.02A 4bkjB-2gcdA:
24.4		 4bkjB-2gcdA:
28.41
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2h8h PROTO-ONCOGENE
TYROSINE-PROTEIN
KINASE SRC

(Homo sapiens) 		PF00017
(SH2)
PF00018
(SH3_1)
PF07714
(Pkinase_Tyr) 		4 LEU A 317
TYR A 340
MET A 341
ARG A 385
 None
H8H  A 534 (-4.3A)
None
None
 0.92A 4bkjB-2h8hA:
29.0		 4bkjB-2h8hA:
25.98
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2i1j MOESIN

(Spodoptera
frugiperda) 		PF00373
(FERM_M)
PF00769
(ERM)
PF09379
(FERM_N)
PF09380
(FERM_C) 		4 LEU A 216
TYR A 116
MET A 539
ARG A 568
 None
 1.44A 4bkjB-2i1jA:
undetectable		 4bkjB-2i1jA:
20.76
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2i6l MITOGEN-ACTIVATED
PROTEIN KINASE 6

(Homo sapiens) 		PF00069
(Pkinase) 		4 LYS A  49
LEU A  72
TYR A 110
MET A 111
 None
 1.12A 4bkjB-2i6lA:
22.0		 4bkjB-2i6lA:
27.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2nyk M157

(Murid
betaherpesvirus
1) 		PF11624
(M157) 		4 LEU A  83
TYR A 151
MET A 152
ARG A 122
 None
 1.47A 4bkjB-2nykA:
undetectable		 4bkjB-2nykA:
18.10
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2og8 PROTO-ONCOGENE
TYROSINE-PROTEIN
KINASE LCK

(Homo sapiens) 		PF07714
(Pkinase_Tyr) 		4 LEU A 295
TYR A 318
MET A 319
ARG A 363
 1N8  A 501 ( 3.9A)
1N8  A 501 ( 3.7A)
1N8  A 501 ( 4.4A)
None
 0.84A 4bkjB-2og8A:
31.4		 4bkjB-2og8A:
37.81
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2q6k CHLORINASE

(Salinispora
tropica) 		PF01887
(SAM_adeno_trans) 		4 LYS A   1
LEU A  92
MET A  26
ARG A 154
 None
 1.36A 4bkjB-2q6kA:
undetectable		 4bkjB-2q6kA:
21.75
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2yhe SEC-ALKYL SULFATASE

(Pseudomonas sp.
DSM 6611) 		PF00753
(Lactamase_B)
PF14863
(Alkyl_sulf_dimr)
PF14864
(Alkyl_sulf_C) 		4 LEU A 661
TYR A 521
MET A 505
ARG A 453
 None
 1.12A 4bkjB-2yheA:
undetectable		 4bkjB-2yheA:
19.21
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3d7u TYROSINE-PROTEIN
KINASE CSK

(Homo sapiens) 		PF07714
(Pkinase_Tyr) 		5 LYS A 222
LEU A 243
TYR A 268
MET A 269
ARG A 313
 None
 1.29A 4bkjB-3d7uA:
24.3		 4bkjB-3d7uA:
32.72
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3e3b CASEIN KINASE II
SUBUNIT ALPHA'

(Homo sapiens) 		PF00069
(Pkinase) 		4 LYS X  69
LEU X  89
TYR X 116
ARG X 156
 CCK  X 351 (-3.5A)
None
CCK  X 351 (-4.3A)
None
 1.10A 4bkjB-3e3bX:
5.2		 4bkjB-3e3bX:
22.89
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3nuu PKB-LIKE

(Homo sapiens) 		PF00069
(Pkinase) 		4 LYS A 111
LEU A 137
TYR A 161
ARG A 204
 SO4  A   5 (-2.8A)
None
None
SEP  A 241 ( 3.4A)
 1.18A 4bkjB-3nuuA:
22.8		 4bkjB-3nuuA:
25.45
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3oz6 MITOGEN-ACTIVATED
PROTEIN KINASE 1,
SERINE/THREONINE
PROTEIN KINASE

(Cryptosporidium
parvum) 		PF00069
(Pkinase) 		4 LEU A  65
TYR A  92
MET A  93
ARG A 133
 None
 1.38A 4bkjB-3oz6A:
19.8		 4bkjB-3oz6A:
25.18
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3ppz SERINE/THREONINE-PRO
TEIN KINASE CTR1

(Arabidopsis
thaliana) 		PF07714
(Pkinase_Tyr) 		4 LYS A 578
LEU A 603
TYR A 627
ARG A 675
 STU  A   1 (-3.5A)
None
STU  A   1 (-4.4A)
SEP  A 710 ( 3.6A)
 1.02A 4bkjB-3ppzA:
27.6		 4bkjB-3ppzA:
31.93
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4ckr EPITHELIAL DISCOIDIN
DOMAIN-CONTAINING
RECEPTOR 1

(Homo sapiens) 		PF07714
(Pkinase_Tyr) 		5 LYS A 655
LEU A 679
TYR A 703
MET A 704
ARG A 765
 DI1  A1000 (-3.9A)
DI1  A1000 (-4.5A)
DI1  A1000 (-4.0A)
None
None
 0.53A 4bkjB-4ckrA:
45.8		 4bkjB-4ckrA:
100.00
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4gl9 TYROSINE-PROTEIN
KINASE

(Mus musculus) 		PF07714
(Pkinase_Tyr) 		4 LYS A 882
LEU A 905
TYR A 931
ARG A 975
 IZA  A2001 ( 4.7A)
None
None
None
 1.14A 4bkjB-4gl9A:
28.2		 4bkjB-4gl9A:
33.23
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4jr7 CASEIN KINASE II
SUBUNIT ALPHA

(Saccharomyces
cerevisiae) 		PF00069
(Pkinase) 		4 LYS A  69
LEU A  89
TYR A 154
ARG A 194
 GNP  A 401 (-3.3A)
None
GNP  A 401 ( 4.5A)
None
 1.33A 4bkjB-4jr7A:
18.9		 4bkjB-4jr7A:
21.05
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4l68 LEUCINE-RICH REPEAT
PROTEIN KINASE-LIKE
PROTEIN

(Arabidopsis
thaliana) 		PF07714
(Pkinase_Tyr) 		4 LYS A 335
LEU A 357
TYR A 381
MET A 382
 None
 0.89A 4bkjB-4l68A:
18.9		 4bkjB-4l68A:
26.08
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4ueu TYROSINE KINASE AS -
A COMMON ANCESTOR OF
SRC AND ABL

(synthetic
construct) 		PF07714
(Pkinase_Tyr) 		5 LYS A  37
LEU A  59
TYR A  83
MET A  84
ARG A 128
 None
None
ACP  A1264 ( 4.5A)
None
None
 1.28A 4bkjB-4ueuA:
29.8		 4bkjB-4ueuA:
39.81
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4xuf RECEPTOR-TYPE
TYROSINE-PROTEIN
KINASE FLT3

(Homo sapiens) 		PF07714
(Pkinase_Tyr) 		4 LYS A 644
LEU A 668
TYR A 693
ARG A 810
 P30  A1001 ( 4.0A)
None
P30  A1001 ( 4.4A)
None
 1.16A 4bkjB-4xufA:
25.1		 4bkjB-4xufA:
33.44
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5a31 ANAPHASE-PROMOTING
COMPLEX SUBUNIT 1

(Homo sapiens) 		PF12859
(ANAPC1) 		4 LEU A1585
TYR A1326
MET A1329
ARG A1475
 None
 1.47A 4bkjB-5a31A:
undetectable		 4bkjB-5a31A:
12.52
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5a31 ANAPHASE-PROMOTING
COMPLEX SUBUNIT 1

(Homo sapiens) 		PF12859
(ANAPC1) 		4 LYS A1700
LEU A1747
TYR A1708
ARG A 956
 None
 1.29A 4bkjB-5a31A:
undetectable		 4bkjB-5a31A:
12.52
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5a53 REGULATOR OF
RIBOSOME
BIOSYNTHESIS
RIBOSOME BIOGENESIS
PROTEIN RPF2

(Saccharomyces
cerevisiae) 		PF04427
(Brix)
no annotation 		4 LYS C 138
LEU C  86
MET C 184
ARG B 101
 None
 1.33A 4bkjB-5a53C:
undetectable		 4bkjB-5a53C:
22.42
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5e72 N2,
N2-DIMETHYLGUANOSINE
TRNA
METHYLTRANSFERASE

(Thermococcus
kodakarensis) 		PF01170
(UPF0020)
PF02926
(THUMP) 		4 LEU A   2
TYR A  34
MET A  93
ARG A  51
 None
 1.34A 4bkjB-5e72A:
undetectable		 4bkjB-5e72A:
22.10
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ig1 CAMK/CAMK2 PROTEIN
KINASE

(Salpingoeca
rosetta) 		PF00069
(Pkinase) 		4 LYS A  47
LEU A  72
TYR A  96
ARG A 139
 None
None
PO4  A 401 (-4.8A)
None
 1.46A 4bkjB-5ig1A:
23.3		 4bkjB-5ig1A:
26.05
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5u94 SERINE/THREONINE-PRO
TEIN KINASE PKNB

(Mycobacterium
tuberculosis) 		no annotation 4 LYS A  40
LEU A  66
TYR A  94
ARG A 137
 G93  A 301 (-3.0A)
None
None
None
 1.38A 4bkjB-5u94A:
24.5		 4bkjB-5u94A:
15.50
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ub6 PHOSPHATE-BINDING
PROTEIN

(Xanthomonas
citri) 		no annotation 4 LEU A 111
TYR A  83
MET A  80
ARG A  60
 None
 1.48A 4bkjB-5ub6A:
undetectable		 4bkjB-5ub6A:
13.86
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ucg STAGE II SPORULATION
PROTEIN E

(Bacillus
subtilis) 		PF07228
(SpoIIE) 		4 LYS A 693
TYR A 622
MET A 615
ARG A 500
 None
 1.43A 4bkjB-5ucgA:
undetectable		 4bkjB-5ucgA:
22.63
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5wxl REGULATOR OF
RIBOSOME
BIOSYNTHESIS
RIBOSOME BIOGENESIS
PROTEIN RPF2

(Saccharomyces
cerevisiae) 		PF04427
(Brix)
PF04939
(RRS1) 		4 LYS A 138
LEU A  86
MET A 184
ARG B 101
 None
 1.33A 4bkjB-5wxlA:
undetectable		 4bkjB-5wxlA:
22.46
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5xvu CASEIN KINASE 2,
ALPHA SUBUNIT

(Plasmodium
falciparum) 		PF00069
(Pkinase) 		4 LYS A  72
LEU A  92
TYR A 119
ARG A 159
 ATP  A 403 (-3.2A)
None
None
SO4  A 401 (-3.0A)
 1.35A 4bkjB-5xvuA:
20.0		 4bkjB-5xvuA:
19.30
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ybb TYPE I
RESTRICTION-MODIFICA
TION SYSTEM
METHYLTRANSFERASE
SUBUNIT

(Caldanaerobacter
subterraneus) 		no annotation 4 LEU A  43
TYR A  33
MET A  21
ARG A 112
 None
 1.19A 4bkjB-5ybbA:
undetectable		 4bkjB-5ybbA:
20.36
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5zya SPLICING FACTOR 3B
SUBUNIT 1

(Homo sapiens) 		no annotation 4 LEU C 747
TYR C 761
MET C 757
ARG C 702
 None
 1.46A 4bkjB-5zyaC:
undetectable		 4bkjB-5zyaC:
12.70
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6b3e CYCLIN-DEPENDENT
KINASE 12

(Homo sapiens) 		no annotation 4 LEU A 781
TYR A 815
MET A 816
ARG A 773
 None
CJM  A1102 (-4.1A)
None
None
 1.31A 4bkjB-6b3eA:
22.6		 4bkjB-6b3eA:
15.04
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6b3e CYCLIN-DEPENDENT
KINASE 12

(Homo sapiens) 		no annotation 4 LEU A 781
TYR A 815
MET A 816
ARG A 858
 None
CJM  A1102 (-4.1A)
None
TPO  A 893 ( 3.0A)
 0.88A 4bkjB-6b3eA:
22.6		 4bkjB-6b3eA:
15.04
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6b3e CYCLIN-DEPENDENT
KINASE 12

(Homo sapiens) 		no annotation 4 LYS A 756
LEU A 781
MET A 816
ARG A 858
 None
None
None
TPO  A 893 ( 3.0A)
 1.12A 4bkjB-6b3eA:
22.6		 4bkjB-6b3eA:
15.04
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6c9d SERINE/THREONINE-PRO
TEIN KINASE
MARK1,SERINE/THREONI
NE-PROTEIN KINASE
MARK1

(Homo sapiens) 		no annotation 4 LYS A  89
LEU A 114
TYR A 138
ARG A 181
 None
 1.14A 4bkjB-6c9dA:
21.1		 4bkjB-6c9dA:
11.78