SIMILAR PATTERNS OF AMINO ACIDS FOR 4BKJ_A_STIA1000_2

List of similar pattern of amino acids derived from ASSAM search

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click link on the last column to view superposed patterns of amino acids in NGL viewer)
(Note that only 3-12 residue patterns can be used for ASSAM searches)
Filter list by:
Hit Macromolecule/
Organism		 Pfam Res. Interface HETATM RMSD Dali Z-score Seq. Identity (%) View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1k9a CARBOXYL-TERMINAL
SRC KINASE

(Rattus
norvegicus) 		PF00017
(SH2)
PF00018
(SH3_1)
PF07714
(Pkinase_Tyr) 		4 LYS A 222
LEU A 243
MET A 269
ARG A 313
 None
 1.15A 4bkjA-1k9aA:
28.5		 4bkjA-1k9aA:
25.05
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2dq7 PROTO-ONCOGENE
TYROSINE-PROTEIN
KINASE FYN

(Homo sapiens) 		PF07714
(Pkinase_Tyr) 		4 LYS X  39
LEU X  61
MET X  85
ARG X 129
 STU  X 902 (-3.1A)
None
None
PTR  X 160 ( 3.4A)
 1.15A 4bkjA-2dq7X:
29.7		 4bkjA-2dq7X:
35.24
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2q6k CHLORINASE

(Salinispora
tropica) 		PF01887
(SAM_adeno_trans) 		4 LYS A   1
LEU A  92
MET A  26
ARG A 154
 None
 1.38A 4bkjA-2q6kA:
0.0		 4bkjA-2q6kA:
21.75
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3d7u TYROSINE-PROTEIN
KINASE CSK

(Homo sapiens) 		PF07714
(Pkinase_Tyr) 		4 LYS A 222
LEU A 243
MET A 269
ARG A 313
 None
 1.15A 4bkjA-3d7uA:
24.3		 4bkjA-3d7uA:
32.72
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4ckr EPITHELIAL DISCOIDIN
DOMAIN-CONTAINING
RECEPTOR 1

(Homo sapiens) 		PF07714
(Pkinase_Tyr) 		4 LYS A 655
LEU A 679
MET A 704
ARG A 765
 DI1  A1000 (-3.9A)
DI1  A1000 (-4.5A)
None
None
 0.52A 4bkjA-4ckrA:
46.2		 4bkjA-4ckrA:
100.00
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4ueu TYROSINE KINASE AS -
A COMMON ANCESTOR OF
SRC AND ABL

(synthetic
construct) 		PF07714
(Pkinase_Tyr) 		4 LYS A  37
LEU A  59
MET A  84
ARG A 128
 None
 1.20A 4bkjA-4ueuA:
29.8		 4bkjA-4ueuA:
39.81
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5a53 REGULATOR OF
RIBOSOME
BIOSYNTHESIS
RIBOSOME BIOGENESIS
PROTEIN RPF2

(Saccharomyces
cerevisiae) 		PF04427
(Brix)
no annotation 		4 LYS C 138
LEU C  86
MET C 184
ARG B 101
 None
 1.31A 4bkjA-5a53C:
undetectable		 4bkjA-5a53C:
22.42
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5wxl REGULATOR OF
RIBOSOME
BIOSYNTHESIS
RIBOSOME BIOGENESIS
PROTEIN RPF2

(Saccharomyces
cerevisiae) 		PF04427
(Brix)
PF04939
(RRS1) 		4 LYS A 138
LEU A  86
MET A 184
ARG B 101
 None
 1.32A 4bkjA-5wxlA:
undetectable		 4bkjA-5wxlA:
22.46
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6b3e CYCLIN-DEPENDENT
KINASE 12

(Homo sapiens) 		no annotation 4 LYS A 756
LEU A 781
MET A 816
ARG A 858
 None
None
None
TPO  A 893 ( 3.0A)
 1.14A 4bkjA-6b3eA:
22.5		 4bkjA-6b3eA:
15.04