SIMILAR PATTERNS OF AMINO ACIDS FOR 4BKJ_A_STIA1000_1

List of similar pattern of amino acids derived from ASSAM search

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click link on the last column to view superposed patterns of amino acids in NGL viewer)
(Note that only 3-12 residue patterns can be used for ASSAM searches)
Filter list by:
Hit Macromolecule/
Organism		 Pfam Res. Interface HETATM RMSD Dali Z-score Seq. Identity (%) View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1fot CAMP-DEPENDENT
PROTEIN KINASE TYPE
1

(Saccharomyces
cerevisiae) 		PF00069
(Pkinase) 		7 VAL A 101
ALA A 114
ILE A 148
MET A 162
TYR A 166
LEU A 217
ASP A 228
 None
 1.02A 4bkjA-1fotA:
21.2		 4bkjA-1fotA:
25.64
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1gng GLYCOGEN SYNTHASE
KINASE-3 BETA

(Homo sapiens) 		PF00069
(Pkinase) 		7 VAL A  70
ALA A  83
GLU A  97
ILE A 100
MET A 101
TYR A 134
LEU A 188
 None
 0.50A 4bkjA-1gngA:
20.5		 4bkjA-1gngA:
23.27
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1k9a CARBOXYL-TERMINAL
SRC KINASE

(Rattus
norvegicus) 		PF00017
(SH2)
PF00018
(SH3_1)
PF07714
(Pkinase_Tyr) 		6 VAL A 209
ALA A 220
GLU A 236
MET A 240
THR A 266
TYR A 268
 None
 0.69A 4bkjA-1k9aA:
28.5		 4bkjA-1k9aA:
25.05
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1luf MUSCLE-SPECIFIC
TYROSINE KINASE
RECEPTOR MUSK

(Rattus
norvegicus) 		PF07714
(Pkinase_Tyr) 		7 VAL A 588
ALA A 606
MET A 629
TYR A 656
LEU A 731
ALA A 741
ASP A 742
 None
 0.89A 4bkjA-1lufA:
28.9		 4bkjA-1lufA:
39.20
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1opk PROTO-ONCOGENE
TYROSINE-PROTEIN
KINASE ABL1

(Mus musculus) 		PF00017
(SH2)
PF00018
(SH3_1)
PF07714
(Pkinase_Tyr) 		7 VAL A 275
ALA A 288
GLU A 305
MET A 309
THR A 334
LEU A 389
ALA A 399
 P16  A   2 (-4.5A)
P16  A   2 (-3.4A)
P16  A   2 (-4.2A)
P16  A   2 (-3.3A)
P16  A   2 (-3.7A)
P16  A   2 (-4.4A)
P16  A   2 (-3.5A)
 0.93A 4bkjA-1opkA:
28.8		 4bkjA-1opkA:
26.49
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1py5 TGF-BETA RECEPTOR
TYPE I

(Homo sapiens) 		PF00069
(Pkinase)
PF08515
(TGF_beta_GS) 		7 VAL A 219
ALA A 230
GLU A 245
ILE A 248
TYR A 282
LEU A 340
ALA A 350
 PY1  A 700 ( 4.7A)
PY1  A 700 (-3.5A)
PY1  A 700 ( 4.9A)
None
PY1  A 700 (-4.6A)
PY1  A 700 (-4.4A)
PY1  A 700 ( 4.2A)
 1.04A 4bkjA-1py5A:
24.3		 4bkjA-1py5A:
25.36
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1t46 HOMO SAPIENS V-KIT
HARDY-ZUCKERMAN 4
FELINE SARCOMA VIRAL
ONCOGENE HOMOLOG

(Homo sapiens) 		PF07714
(Pkinase_Tyr) 		7 VAL A 603
ALA A 621
GLU A 640
THR A 670
TYR A 672
LEU A 799
ASP A 810
 STI  A   3 ( 4.6A)
STI  A   3 (-3.5A)
STI  A   3 (-3.6A)
STI  A   3 (-3.2A)
STI  A   3 ( 4.0A)
STI  A   3 (-4.4A)
STI  A   3 (-3.9A)
 0.87A 4bkjA-1t46A:
33.6		 4bkjA-1t46A:
32.84
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1u59 TYROSINE-PROTEIN
KINASE ZAP-70

(Homo sapiens) 		PF07714
(Pkinase_Tyr) 		6 VAL A 352
ALA A 367
GLU A 386
ILE A 389
MET A 390
LEU A 468
 STU  A 100 (-4.8A)
STU  A 100 (-3.2A)
None
None
None
STU  A 100 (-4.5A)
 0.90A 4bkjA-1u59A:
28.7		 4bkjA-1u59A:
33.44
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2dq7 PROTO-ONCOGENE
TYROSINE-PROTEIN
KINASE FYN

(Homo sapiens) 		PF07714
(Pkinase_Tyr) 		8 ALA X  37
GLU X  54
ILE X  57
MET X  58
THR X  82
TYR X  84
ALA X 147
ASP X 148
 STU  X 902 (-3.1A)
STU  X 902 ( 4.4A)
None
None
STU  X 902 (-4.1A)
STU  X 902 (-4.6A)
STU  X 902 ( 4.1A)
STU  X 902 (-3.6A)
 1.09A 4bkjA-2dq7X:
29.7		 4bkjA-2dq7X:
35.24
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2dq7 PROTO-ONCOGENE
TYROSINE-PROTEIN
KINASE FYN

(Homo sapiens) 		PF07714
(Pkinase_Tyr) 		9 VAL X  25
ALA X  37
GLU X  54
ILE X  57
MET X  58
THR X  82
TYR X  84
LEU X 137
ALA X 147
 STU  X 902 ( 4.8A)
STU  X 902 (-3.1A)
STU  X 902 ( 4.4A)
None
None
STU  X 902 (-4.1A)
STU  X 902 (-4.6A)
STU  X 902 (-4.4A)
STU  X 902 ( 4.1A)
 1.09A 4bkjA-2dq7X:
29.7		 4bkjA-2dq7X:
35.24
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2hen EPHRIN TYPE-B
RECEPTOR 2

(Mus musculus) 		PF07714
(Pkinase_Tyr) 		7 ALA A 659
ILE A 681
MET A 682
ILE A 691
THR A 707
LEU A 761
ASP A 772
 ADP  A 400 (-3.2A)
None
None
None
ADP  A 400 (-4.7A)
ADP  A 400 ( 4.7A)
ADP  A 400 ( 4.8A)
 1.01A 4bkjA-2henA:
29.8		 4bkjA-2henA:
37.08
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2hen EPHRIN TYPE-B
RECEPTOR 2

(Mus musculus) 		PF07714
(Pkinase_Tyr) 		7 VAL A 643
ALA A 659
MET A 682
ILE A 691
THR A 707
LEU A 761
ASP A 772
 ADP  A 400 ( 4.4A)
ADP  A 400 (-3.2A)
None
None
ADP  A 400 (-4.7A)
ADP  A 400 ( 4.7A)
ADP  A 400 ( 4.8A)
 1.15A 4bkjA-2henA:
29.8		 4bkjA-2henA:
37.08
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2hk5 TYROSINE-PROTEIN
KINASE HCK

(Homo sapiens) 		PF07714
(Pkinase_Tyr) 		6 ALA A 271
MET A 292
THR A 316
LEU A 371
ALA A 381
ASP A 382
 1BM  A 499 (-3.6A)
1BM  A 499 ( 3.8A)
1BM  A 499 (-3.2A)
1BM  A 499 (-4.4A)
1BM  A 499 ( 3.7A)
1BM  A 499 (-4.4A)
 0.85A 4bkjA-2hk5A:
29.3		 4bkjA-2hk5A:
35.22
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2hz0 PROTO-ONCOGENE
TYROSINE-PROTEIN
KINASE ABL1

(Homo sapiens) 		PF07714
(Pkinase_Tyr) 		7 ALA A 269
GLU A 286
MET A 290
THR A 315
LEU A 370
ALA A 380
ASP A 381
 GIN  A 600 (-3.1A)
GIN  A 600 (-3.6A)
GIN  A 600 (-3.2A)
GIN  A 600 (-3.4A)
GIN  A 600 (-4.7A)
GIN  A 600 (-3.1A)
GIN  A 600 (-4.9A)
 0.74A 4bkjA-2hz0A:
30.0		 4bkjA-2hz0A:
38.05
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2hz0 PROTO-ONCOGENE
TYROSINE-PROTEIN
KINASE ABL1

(Homo sapiens) 		PF07714
(Pkinase_Tyr) 		7 VAL A 256
ALA A 269
GLU A 286
MET A 290
THR A 315
LEU A 370
ALA A 380
 GIN  A 600 ( 4.7A)
GIN  A 600 (-3.1A)
GIN  A 600 (-3.6A)
GIN  A 600 (-3.2A)
GIN  A 600 (-3.4A)
GIN  A 600 (-4.7A)
GIN  A 600 (-3.1A)
 0.83A 4bkjA-2hz0A:
30.0		 4bkjA-2hz0A:
38.05
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2og8 PROTO-ONCOGENE
TYROSINE-PROTEIN
KINASE LCK

(Homo sapiens) 		PF07714
(Pkinase_Tyr) 		9 VAL A 259
ALA A 271
GLU A 288
MET A 292
THR A 316
TYR A 318
LEU A 371
ALA A 381
ASP A 382
 None
1N8  A 501 ( 3.4A)
1N8  A 501 ( 3.6A)
1N8  A 501 ( 3.6A)
1N8  A 501 ( 3.3A)
1N8  A 501 ( 3.7A)
1N8  A 501 ( 4.3A)
1N8  A 501 ( 3.3A)
1N8  A 501 ( 3.3A)
 0.65A 4bkjA-2og8A:
31.5		 4bkjA-2og8A:
37.81
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2ogv MACROPHAGE
COLONY-STIMULATING
FACTOR 1 RECEPTOR
PRECURSOR

(Homo sapiens) 		PF07714
(Pkinase_Tyr) 		7 ALA A 614
GLU A 633
ILE A 636
MET A 637
THR A 663
TYR A 665
LEU A 785
 None
 1.10A 4bkjA-2ogvA:
31.5		 4bkjA-2ogvA:
35.47
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2ogv MACROPHAGE
COLONY-STIMULATING
FACTOR 1 RECEPTOR
PRECURSOR

(Homo sapiens) 		PF07714
(Pkinase_Tyr) 		8 VAL A 596
ALA A 614
GLU A 633
ILE A 636
MET A 637
THR A 663
TYR A 665
ASP A 796
 None
 0.94A 4bkjA-2ogvA:
31.5		 4bkjA-2ogvA:
35.47
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2p4i ANGIOPOIETIN-1
RECEPTOR

(Homo sapiens) 		PF07714
(Pkinase_Tyr) 		7 VAL A 838
ALA A 853
ILE A 886
TYR A 904
LEU A 971
ALA A 981
ASP A 982
 MR9  A 301 (-4.6A)
MR9  A 301 (-3.5A)
MR9  A 301 (-4.0A)
MR9  A 301 (-3.8A)
MR9  A 301 (-4.5A)
MR9  A 301 (-3.2A)
MR9  A 301 (-4.2A)
 0.62A 4bkjA-2p4iA:
21.8		 4bkjA-2p4iA:
33.52
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2psq FIBROBLAST GROWTH
FACTOR RECEPTOR 2

(Homo sapiens) 		PF07714
(Pkinase_Tyr) 		8 VAL A 495
ALA A 515
GLU A 534
MET A 538
ILE A 548
TYR A 566
LEU A 633
ALA A 643
 None
 1.07A 4bkjA-2psqA:
29.5		 4bkjA-2psqA:
33.52
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2qob EPHRIN RECEPTOR

(Homo sapiens) 		PF07714
(Pkinase_Tyr) 		6 VAL A 635
ALA A 651
ILE A 673
ILE A 683
THR A 699
ASP A 764
 BME  A   1 (-4.9A)
PTR  A 701 ( 4.7A)
None
None
None
None
 0.77A 4bkjA-2qobA:
24.6		 4bkjA-2qobA:
34.36
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2r2p EPHRIN TYPE-A
RECEPTOR 5

(Homo sapiens) 		PF07714
(Pkinase_Tyr)
PF14575
(EphA2_TM) 		9 VAL A 689
ALA A 705
GLU A 724
ILE A 727
MET A 728
ILE A 737
THR A 753
TYR A 755
ASP A 818
 None
 0.94A 4bkjA-2r2pA:
30.7		 4bkjA-2r2pA:
35.98
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2r2p EPHRIN TYPE-A
RECEPTOR 5

(Homo sapiens) 		PF07714
(Pkinase_Tyr)
PF14575
(EphA2_TM) 		8 VAL A 689
ALA A 705
ILE A 727
MET A 728
ILE A 737
THR A 753
TYR A 755
LEU A 807
 None
 1.01A 4bkjA-2r2pA:
30.7		 4bkjA-2r2pA:
35.98
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2vd5 DMPK PROTEIN

(Homo sapiens) 		PF00069
(Pkinase) 		6 VAL A  85
ALA A  98
GLU A 119
TYR A 150
LEU A 202
ALA A 212
 BI8  A1417 ( 4.7A)
BI8  A1417 ( 3.8A)
BI8  A1417 ( 4.9A)
BI8  A1417 (-4.8A)
BI8  A1417 (-4.8A)
BI8  A1417 ( 4.1A)
 0.77A 4bkjA-2vd5A:
14.0		 4bkjA-2vd5A:
26.38
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2wtk SERINE/THREONINE-PRO
TEIN KINASE 11

(Homo sapiens) 		PF00069
(Pkinase) 		7 VAL C  63
ALA C  76
GLU C  98
ILE C 111
MET C 127
TYR C 131
LEU C 183
 ANP  C   2 (-4.2A)
ANP  C   2 (-3.4A)
None
None
None
None
None
 1.43A 4bkjA-2wtkC:
22.0		 4bkjA-2wtkC:
25.42
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2xyu EPHRIN TYPE-A
RECEPTOR 4,

(Mus musculus) 		PF07714
(Pkinase_Tyr) 		9 VAL A 635
ALA A 651
ILE A 673
MET A 674
ILE A 683
THR A 699
TYR A 701
LEU A 753
ASP A 764
 Q9G  A1898 ( 4.7A)
Q9G  A1898 (-3.2A)
None
Q9G  A1898 (-3.9A)
Q9G  A1898 ( 4.9A)
Q9G  A1898 (-3.5A)
Q9G  A1898 (-4.8A)
Q9G  A1898 (-4.3A)
None
 0.98A 4bkjA-2xyuA:
27.3		 4bkjA-2xyuA:
35.89
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2zmc DUAL SPECIFICITY
PROTEIN KINASE TTK

(Homo sapiens) 		PF00069
(Pkinase) 		6 VAL A 539
ALA A 551
ILE A 586
MET A 600
LEU A 654
ASP A 664
 None
None
None
7PE  A   1 (-3.4A)
None
None
 0.79A 4bkjA-2zmcA:
22.7		 4bkjA-2zmcA:
21.86
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3b2t FIBROBLAST GROWTH
FACTOR RECEPTOR 2

(Homo sapiens) 		PF07714
(Pkinase_Tyr) 		6 ALA A 515
MET A 538
ILE A 548
TYR A 566
LEU A 633
ALA A 643
 M33  A1996 (-3.3A)
None
None
M33  A1996 ( 4.7A)
M33  A1996 (-4.5A)
None
 0.85A 4bkjA-3b2tA:
25.7		 4bkjA-3b2tA:
34.42
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3b2t FIBROBLAST GROWTH
FACTOR RECEPTOR 2

(Homo sapiens) 		PF07714
(Pkinase_Tyr) 		6 VAL A 495
ALA A 515
GLU A 534
MET A 538
ILE A 548
TYR A 566
 M33  A1996 ( 4.7A)
M33  A1996 (-3.3A)
None
None
None
M33  A1996 ( 4.7A)
 0.87A 4bkjA-3b2tA:
25.7		 4bkjA-3b2tA:
34.42
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3b2t FIBROBLAST GROWTH
FACTOR RECEPTOR 2

(Homo sapiens) 		PF07714
(Pkinase_Tyr) 		6 VAL A 495
ALA A 515
MET A 538
ILE A 548
TYR A 566
ALA A 643
 M33  A1996 ( 4.7A)
M33  A1996 (-3.3A)
None
None
M33  A1996 ( 4.7A)
None
 0.81A 4bkjA-3b2tA:
25.7		 4bkjA-3b2tA:
34.42
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3bhh CALCIUM/CALMODULIN-D
EPENDENT PROTEIN
KINASE TYPE II BETA
CHAIN

(Homo sapiens) 		PF00069
(Pkinase) 		6 VAL A  28
ALA A  41
GLU A  61
ILE A  64
LEU A 143
ALA A 156
 5CP  A 600 ( 4.4A)
5CP  A 600 (-3.6A)
None
None
5CP  A 600 (-4.4A)
5CP  A 600 ( 3.9A)
 0.86A 4bkjA-3bhhA:
23.0		 4bkjA-3bhhA:
25.94
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3c1x HEPATOCYTE GROWTH
FACTOR RECEPTOR

(Homo sapiens) 		PF07714
(Pkinase_Tyr) 		8 VAL A1092
ALA A1108
GLU A1127
ILE A1130
MET A1131
TYR A1159
ALA A1221
ASP A1222
 CKK  A1500 ( 4.3A)
CKK  A1500 (-3.2A)
CKK  A1500 (-3.4A)
None
CKK  A1500 (-3.4A)
CKK  A1500 (-4.5A)
CKK  A1500 (-3.4A)
CKK  A1500 (-4.5A)
 1.00A 4bkjA-3c1xA:
24.9		 4bkjA-3c1xA:
32.75
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3c4f BASIC FIBROBLAST
GROWTH FACTOR
RECEPTOR 1

(Homo sapiens) 		PF07714
(Pkinase_Tyr) 		8 VAL A 492
ALA A 512
GLU A 531
MET A 535
ILE A 545
TYR A 563
LEU A 630
ALA A 640
 None
C4F  A   1 (-3.3A)
None
C4F  A   1 ( 3.7A)
C4F  A   1 ( 4.0A)
None
C4F  A   1 (-4.6A)
C4F  A   1 (-3.6A)
 1.05A 4bkjA-3c4fA:
26.5		 4bkjA-3c4fA:
37.58
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3d7u TYROSINE-PROTEIN
KINASE CSK

(Homo sapiens) 		PF07714
(Pkinase_Tyr) 		6 VAL A 209
ALA A 220
GLU A 236
MET A 240
THR A 266
TYR A 268
 None
 0.69A 4bkjA-3d7uA:
24.3		 4bkjA-3d7uA:
32.72
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3e3p PROTEIN KINASE,
PUTATIVE GLYCOGEN
SYNTHASE KINASE

(Leishmania
major) 		PF00069
(Pkinase) 		6 VAL A  34
ALA A  47
GLU A  61
ILE A  64
MET A  65
LEU A 158
 None
 0.59A 4bkjA-3e3pA:
19.0		 4bkjA-3e3pA:
24.37
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3eb0 PUTATIVE
UNCHARACTERIZED
PROTEIN

(Cryptosporidium
parvum) 		PF00069
(Pkinase) 		7 VAL A  23
ALA A  36
GLU A  50
ILE A  53
MET A  54
ILE A  63
LEU A 173
 None
DRK  A 384 (-3.5A)
None
None
None
DRK  A 384 ( 4.5A)
DRK  A 384 (-4.4A)
 0.64A 4bkjA-3eb0A:
20.8		 4bkjA-3eb0A:
24.57
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3eb0 PUTATIVE
UNCHARACTERIZED
PROTEIN

(Cryptosporidium
parvum) 		PF00069
(Pkinase) 		7 VAL A  23
ALA A  36
GLU A  50
ILE A  53
MET A  54
TYR A 119
LEU A 173
 None
DRK  A 384 (-3.5A)
None
None
None
DRK  A 384 (-4.4A)
DRK  A 384 (-4.4A)
 0.81A 4bkjA-3eb0A:
20.8		 4bkjA-3eb0A:
24.57
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3gp0 MITOGEN-ACTIVATED
PROTEIN KINASE 11

(Homo sapiens) 		PF00069
(Pkinase) 		6 VAL A  38
ALA A  51
GLU A  71
ILE A  84
THR A 106
ASP A 168
 NIL  A   1 ( 4.7A)
NIL  A   1 (-3.7A)
NIL  A   1 (-3.7A)
NIL  A   1 (-4.4A)
NIL  A   1 (-3.3A)
NIL  A   1 (-4.6A)
 0.52A 4bkjA-3gp0A:
22.2		 4bkjA-3gp0A:
25.74
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3hng VASCULAR ENDOTHELIAL
GROWTH FACTOR
RECEPTOR 1

(Homo sapiens) 		PF07714
(Pkinase_Tyr) 		7 VAL A 841
ALA A 859
GLU A 878
ILE A 881
TYR A 911
LEU A1029
ASP A1040
 8ST  A2001 ( 4.6A)
8ST  A2001 ( 3.8A)
8ST  A2001 (-3.7A)
None
8ST  A2001 (-4.9A)
None
None
 0.93A 4bkjA-3hngA:
32.6		 4bkjA-3hngA:
30.08
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3iec SERINE/THREONINE-PRO
TEIN KINASE MARK2

(Homo sapiens) 		PF00069
(Pkinase)
PF00627
(UBA) 		7 GLU A 100
ILE A 103
MET A 104
TYR A 131
LEU A 182
ALA A 192
ASP A 193
 None
 1.30A 4bkjA-3iecA:
21.9		 4bkjA-3iecA:
26.43
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3iec SERINE/THREONINE-PRO
TEIN KINASE MARK2

(Homo sapiens) 		PF00069
(Pkinase)
PF00627
(UBA) 		7 VAL A  67
ALA A  80
MET A 104
TYR A 131
LEU A 182
ALA A 192
ASP A 193
 None
 0.99A 4bkjA-3iecA:
21.9		 4bkjA-3iecA:
26.43
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3kul EPHRIN TYPE-A
RECEPTOR 8

(Homo sapiens) 		PF07714
(Pkinase_Tyr)
PF14575
(EphA2_TM) 		8 ALA A 665
GLU A 684
ILE A 687
MET A 688
ILE A 697
THR A 713
TYR A 715
LEU A 767
 None
None
None
None
None
None
GOL  A 403 (-4.1A)
None
 1.06A 4bkjA-3kulA:
27.0		 4bkjA-3kulA:
37.18
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3kul EPHRIN TYPE-A
RECEPTOR 8

(Homo sapiens) 		PF07714
(Pkinase_Tyr)
PF14575
(EphA2_TM) 		8 VAL A 649
ALA A 665
GLU A 684
MET A 688
ILE A 697
THR A 713
TYR A 715
LEU A 767
 None
None
None
None
None
None
GOL  A 403 (-4.1A)
None
 0.99A 4bkjA-3kulA:
27.0		 4bkjA-3kulA:
37.18
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3mdy BONE MORPHOGENETIC
PROTEIN RECEPTOR
TYPE-1B

(Homo sapiens) 		PF07714
(Pkinase_Tyr)
PF08515
(TGF_beta_GS) 		6 ALA A 229
GLU A 244
ILE A 247
THR A 279
TYR A 281
LEU A 339
 LDN  A   1 (-3.6A)
None
None
LDN  A   1 (-3.8A)
LDN  A   1 ( 4.8A)
LDN  A   1 (-4.5A)
 0.77A 4bkjA-3mdyA:
24.0		 4bkjA-3mdyA:
24.79
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3mdy BONE MORPHOGENETIC
PROTEIN RECEPTOR
TYPE-1B

(Homo sapiens) 		PF07714
(Pkinase_Tyr)
PF08515
(TGF_beta_GS) 		6 ALA A 229
ILE A 247
THR A 279
TYR A 281
LEU A 339
ALA A 349
 LDN  A   1 (-3.6A)
None
LDN  A   1 (-3.8A)
LDN  A   1 ( 4.8A)
LDN  A   1 (-4.5A)
LDN  A   1 ( 3.8A)
 0.77A 4bkjA-3mdyA:
24.0		 4bkjA-3mdyA:
24.79
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3mdy BONE MORPHOGENETIC
PROTEIN RECEPTOR
TYPE-1B

(Homo sapiens) 		PF07714
(Pkinase_Tyr)
PF08515
(TGF_beta_GS) 		6 VAL A 218
ALA A 229
GLU A 244
ILE A 247
THR A 279
TYR A 281
 LDN  A   1 ( 4.8A)
LDN  A   1 (-3.6A)
None
None
LDN  A   1 (-3.8A)
LDN  A   1 ( 4.8A)
 0.52A 4bkjA-3mdyA:
24.0		 4bkjA-3mdyA:
24.79
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3mvj CAMP-DEPENDENT
PROTEIN KINASE
CATALYTIC SUBUNIT
ALPHA

(Homo sapiens) 		PF00069
(Pkinase) 		6 VAL A  57
ALA A  70
GLU A  91
ILE A  94
MET A 118
TYR A 122
 XFE  A 351 ( 4.5A)
XFE  A 351 (-3.2A)
None
None
None
None
 0.65A 4bkjA-3mvjA:
21.1		 4bkjA-3mvjA:
24.93
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3my0 SERINE/THREONINE-PRO
TEIN KINASE RECEPTOR
R3

(Homo sapiens) 		PF07714
(Pkinase_Tyr) 		7 ALA A 227
ILE A 245
THR A 277
TYR A 279
LEU A 337
ALA A 347
ASP A 348
 LDN  A 600 (-3.2A)
None
LDN  A 600 (-4.0A)
LDN  A 600 (-4.7A)
LDN  A 600 (-4.6A)
LDN  A 600 ( 3.8A)
None
 0.85A 4bkjA-3my0A:
23.9		 4bkjA-3my0A:
27.30
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3my0 SERINE/THREONINE-PRO
TEIN KINASE RECEPTOR
R3

(Homo sapiens) 		PF07714
(Pkinase_Tyr) 		7 VAL A 216
ALA A 227
ILE A 245
THR A 277
LEU A 337
ALA A 347
ASP A 348
 LDN  A 600 (-4.5A)
LDN  A 600 (-3.2A)
None
LDN  A 600 (-4.0A)
LDN  A 600 (-4.6A)
LDN  A 600 ( 3.8A)
None
 1.25A 4bkjA-3my0A:
23.9		 4bkjA-3my0A:
27.30
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3nuu PKB-LIKE

(Homo sapiens) 		PF00069
(Pkinase) 		6 VAL A  96
ALA A 109
GLU A 130
MET A 134
TYR A 161
ASP A 223
 JOZ  A 361 ( 4.7A)
JOZ  A 361 (-3.4A)
SO4  A   5 (-3.1A)
None
None
SO4  A   5 ( 4.5A)
 0.86A 4bkjA-3nuuA:
22.8		 4bkjA-3nuuA:
25.45
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3ppz SERINE/THREONINE-PRO
TEIN KINASE CTR1

(Arabidopsis
thaliana) 		PF07714
(Pkinase_Tyr) 		7 ALA A 576
GLU A 596
ILE A 599
MET A 600
THR A 625
TYR A 627
LEU A 683
 STU  A   1 (-3.3A)
None
None
None
STU  A   1 (-4.1A)
STU  A   1 (-4.4A)
STU  A   1 (-4.3A)
 0.93A 4bkjA-3ppzA:
27.5		 4bkjA-3ppzA:
31.93
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3qfv CDC42BPB PROTEIN

(Homo sapiens) 		PF00069
(Pkinase) 		6 VAL A  90
ALA A 103
GLU A 124
TYR A 155
LEU A 207
ALA A 217
 NM7  A 416 (-3.7A)
NM7  A 416 ( 3.7A)
EDO  A 417 (-4.0A)
NM7  A 416 (-4.4A)
NM7  A 416 ( 4.2A)
NM7  A 416 ( 4.5A)
 0.84A 4bkjA-3qfvA:
19.0		 4bkjA-3qfvA:
24.15
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3tt0 BASIC FIBROBLAST
GROWTH FACTOR
RECEPTOR 1

(Homo sapiens) 		PF07714
(Pkinase_Tyr) 		6 VAL A 492
ALA A 512
GLU A 531
ILE A 545
LEU A 630
ALA A 640
 07J  A   1 (-4.0A)
07J  A   1 (-3.5A)
07J  A   1 (-3.8A)
07J  A   1 (-3.8A)
07J  A   1 ( 4.4A)
07J  A   1 (-3.2A)
 0.78A 4bkjA-3tt0A:
30.2		 4bkjA-3tt0A:
31.06
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3tt0 BASIC FIBROBLAST
GROWTH FACTOR
RECEPTOR 1

(Homo sapiens) 		PF07714
(Pkinase_Tyr) 		6 VAL A 492
ALA A 512
GLU A 531
TYR A 563
LEU A 630
ALA A 640
 07J  A   1 (-4.0A)
07J  A   1 (-3.5A)
07J  A   1 (-3.8A)
07J  A   1 (-4.7A)
07J  A   1 ( 4.4A)
07J  A   1 (-3.2A)
 0.74A 4bkjA-3tt0A:
30.2		 4bkjA-3tt0A:
31.06
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3zfx EPHRIN TYPE-B
RECEPTOR 1

(Homo sapiens) 		PF07714
(Pkinase_Tyr) 		6 VAL A 633
ALA A 649
GLU A 668
ILE A 671
ILE A 681
THR A 697
 None
 0.83A 4bkjA-3zfxA:
30.5		 4bkjA-3zfxA:
37.16
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3zfx EPHRIN TYPE-B
RECEPTOR 1

(Homo sapiens) 		PF07714
(Pkinase_Tyr) 		6 VAL A 633
ALA A 649
GLU A 668
MET A 672
ILE A 681
THR A 697
 None
 0.89A 4bkjA-3zfxA:
30.5		 4bkjA-3zfxA:
37.16
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4agu CYCLIN-DEPENDENT
KINASE-LIKE 1

(Homo sapiens) 		PF00069
(Pkinase) 		6 VAL A  18
ALA A  31
GLU A  51
TYR A  82
LEU A 133
ASP A 144
 D15  A 500 (-4.6A)
D15  A 500 (-3.4A)
None
D15  A 500 (-4.8A)
D15  A 500 (-4.5A)
D15  A 500 (-3.7A)
 0.87A 4bkjA-4aguA:
22.9		 4bkjA-4aguA:
25.48
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4at3 BDNF/NT-3 GROWTH
FACTORS RECEPTOR

(Homo sapiens) 		PF07714
(Pkinase_Tyr) 		6 VAL A 568
ALA A 586
MET A 631
TYR A 635
LEU A 699
ASP A 710
 None
LTI  A1839 (-3.3A)
None
LTI  A1839 (-4.7A)
LTI  A1839 (-4.2A)
None
 0.83A 4bkjA-4at3A:
31.0		 4bkjA-4at3A:
47.06
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4aw2 SERINE/THREONINE-PRO
TEIN KINASE MRCK
ALPHA

(Rattus
norvegicus) 		PF00069
(Pkinase)
PF00433
(Pkinase_C) 		6 VAL A  91
ALA A 104
GLU A 125
TYR A 156
LEU A 208
ALA A 218
 None
EDO  A1420 (-3.4A)
EDO  A1419 (-3.0A)
EDO  A1420 (-4.9A)
EDO  A1420 ( 4.8A)
None
 0.76A 4bkjA-4aw2A:
20.0		 4bkjA-4aw2A:
25.16
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4aw5 EPHRIN TYPE-B
RECEPTOR 4

(Homo sapiens) 		PF07714
(Pkinase_Tyr) 		7 VAL A 105
ALA A 121
ILE A 143
MET A 144
ILE A 153
THR A 169
LEU A 223
 30K  A1365 ( 4.6A)
30K  A1365 (-3.2A)
None
None
None
30K  A1365 (-3.8A)
30K  A1365 (-4.5A)
 1.10A 4bkjA-4aw5A:
27.0		 4bkjA-4aw5A:
37.54
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4bc6 SERINE/THREONINE-PRO
TEIN KINASE 10

(Homo sapiens) 		PF00069
(Pkinase) 		6 VAL A  50
ALA A  63
GLU A  81
ILE A  84
LEU A 164
ALA A 174
 XZN  A1317 ( 4.7A)
XZN  A1317 (-3.5A)
XZN  A1317 (-3.9A)
None
XZN  A1317 (-4.7A)
XZN  A1317 ( 4.3A)
 0.86A 4bkjA-4bc6A:
20.6		 4bkjA-4bc6A:
26.67
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4cfh 5'-AMP-ACTIVATED
PROTEIN KINASE
CATALYTIC SUBUNIT
ALPHA-1

(Rattus
norvegicus) 		PF00069
(Pkinase)
PF16579
(AdenylateSensor) 		7 VAL A  30
ALA A  43
GLU A  64
ILE A  77
MET A  91
LEU A 146
ALA A 156
 None
STU  A1550 (-3.1A)
None
STU  A1550 ( 4.3A)
None
STU  A1550 (-4.3A)
STU  A1550 ( 3.8A)
 1.18A 4bkjA-4cfhA:
17.6		 4bkjA-4cfhA:
21.79
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4cfh 5'-AMP-ACTIVATED
PROTEIN KINASE
CATALYTIC SUBUNIT
ALPHA-1

(Rattus
norvegicus) 		PF00069
(Pkinase)
PF16579
(AdenylateSensor) 		7 VAL A  30
ALA A  43
GLU A  64
MET A  91
TYR A  95
LEU A 146
ALA A 156
 None
STU  A1550 (-3.1A)
None
None
STU  A1550 (-4.5A)
STU  A1550 (-4.3A)
STU  A1550 ( 3.8A)
 1.13A 4bkjA-4cfhA:
17.6		 4bkjA-4cfhA:
21.79
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4ckr EPITHELIAL DISCOIDIN
DOMAIN-CONTAINING
RECEPTOR 1

(Homo sapiens) 		PF07714
(Pkinase_Tyr) 		12 VAL A 624
ALA A 653
GLU A 672
ILE A 675
MET A 676
ILE A 685
MET A 699
THR A 701
TYR A 703
LEU A 773
ALA A 783
ASP A 784
 DI1  A1000 (-4.8A)
DI1  A1000 (-3.6A)
DI1  A1000 (-3.8A)
None
DI1  A1000 (-3.6A)
DI1  A1000 (-4.5A)
DI1  A1000 ( 4.1A)
DI1  A1000 (-3.6A)
DI1  A1000 (-4.0A)
DI1  A1000 (-4.5A)
DI1  A1000 (-3.7A)
DI1  A1000 (-4.1A)
 0.32A 4bkjA-4ckrA:
46.2		 4bkjA-4ckrA:
100.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4crs SERINE/THREONINE-PRO
TEIN KINASE N2

(Homo sapiens) 		PF00069
(Pkinase)
PF00433
(Pkinase_C) 		7 VAL A 671
ALA A 684
GLU A 705
ILE A 708
TYR A 739
LEU A 789
ALA A 799
 AGS  A1985 (-4.6A)
AGS  A1985 (-3.5A)
None
None
None
AGS  A1985 (-4.8A)
AGS  A1985 ( 4.5A)
 1.33A 4bkjA-4crsA:
20.4		 4bkjA-4crsA:
24.58
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4f0g SERINE/THREONINE-PRO
TEIN KINASE ROCO4

(Dictyostelium
discoideum) 		PF07714
(Pkinase_Tyr) 		6 ALA A1053
GLU A1078
ILE A1081
MET A1082
MET A1103
ALA A1176
 None
 0.62A 4bkjA-4f0gA:
19.4		 4bkjA-4f0gA:
29.85
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4f0g SERINE/THREONINE-PRO
TEIN KINASE ROCO4

(Dictyostelium
discoideum) 		PF07714
(Pkinase_Tyr) 		6 VAL A1040
ALA A1053
GLU A1078
ILE A1081
MET A1103
ALA A1176
 None
 0.59A 4bkjA-4f0gA:
19.4		 4bkjA-4f0gA:
29.85
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4fr4 SERINE/THREONINE-PRO
TEIN KINASE 32A

(Homo sapiens) 		PF00069
(Pkinase) 		7 VAL A  37
ALA A  50
GLU A  71
ILE A  74
MET A  75
MET A  98
LEU A 153
 STU  A 401 ( 4.9A)
STU  A 401 (-3.2A)
None
None
None
None
STU  A 401 (-4.7A)
 1.05A 4bkjA-4fr4A:
20.5		 4bkjA-4fr4A:
23.41
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4hvi TYROSINE-PROTEIN
KINASE JAK3

(Homo sapiens) 		PF07714
(Pkinase_Tyr) 		7 VAL A 836
ALA A 853
GLU A 871
ILE A 874
TYR A 904
LEU A 956
ALA A 966
 19S  A1201 (-4.4A)
19S  A1201 (-3.3A)
None
None
19S  A1201 (-4.7A)
19S  A1201 (-4.5A)
19S  A1201 ( 4.1A)
 0.87A 4bkjA-4hviA:
23.3		 4bkjA-4hviA:
33.33
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4id7 ACTIVATED CDC42
KINASE 1

(Homo sapiens) 		PF07714
(Pkinase_Tyr) 		7 ALA A 156
GLU A 177
ILE A 190
MET A 203
THR A 205
LEU A 259
ASP A 270
 1G0  A 401 (-3.6A)
1G0  A 401 ( 4.5A)
1G0  A 401 (-4.3A)
1G0  A 401 ( 3.7A)
1G0  A 401 (-3.2A)
1G0  A 401 (-4.6A)
None
 1.32A 4bkjA-4id7A:
28.3		 4bkjA-4id7A:
36.99
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4id7 ACTIVATED CDC42
KINASE 1

(Homo sapiens) 		PF07714
(Pkinase_Tyr) 		7 VAL A 140
ALA A 156
ILE A 190
MET A 203
THR A 205
LEU A 259
ASP A 270
 1G0  A 401 (-4.4A)
1G0  A 401 (-3.6A)
1G0  A 401 (-4.3A)
1G0  A 401 ( 3.7A)
1G0  A 401 (-3.2A)
1G0  A 401 (-4.6A)
None
 1.18A 4bkjA-4id7A:
28.3		 4bkjA-4id7A:
36.99
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4k33 FIBROBLAST GROWTH
FACTOR RECEPTOR 3

(Homo sapiens) 		PF07714
(Pkinase_Tyr) 		7 ALA A 506
GLU A 525
MET A 529
ILE A 539
TYR A 557
LEU A 624
ALA A 634
 ACP  A 801 (-3.3A)
ACP  A 801 ( 4.8A)
None
None
None
ACP  A 801 (-4.4A)
None
 1.01A 4bkjA-4k33A:
25.3		 4bkjA-4k33A:
34.69
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4k33 FIBROBLAST GROWTH
FACTOR RECEPTOR 3

(Homo sapiens) 		PF07714
(Pkinase_Tyr) 		6 ALA A 506
MET A 529
ILE A 539
TYR A 557
ALA A 634
ASP A 635
 ACP  A 801 (-3.3A)
None
None
None
None
MG  A 802 ( 3.0A)
 0.73A 4bkjA-4k33A:
25.3		 4bkjA-4k33A:
34.69
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4k33 FIBROBLAST GROWTH
FACTOR RECEPTOR 3

(Homo sapiens) 		PF07714
(Pkinase_Tyr) 		7 VAL A 486
ALA A 506
GLU A 525
MET A 529
ILE A 539
TYR A 557
ALA A 634
 ACP  A 801 (-4.2A)
ACP  A 801 (-3.3A)
ACP  A 801 ( 4.8A)
None
None
None
None
 0.84A 4bkjA-4k33A:
25.3		 4bkjA-4k33A:
34.69
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4lg4 SERINE/THREONINE-PRO
TEIN KINASE 3

(Homo sapiens) 		PF00069
(Pkinase) 		7 VAL A  41
ALA A  54
GLU A  70
ILE A  73
MET A  74
TYR A 101
ALA A 163
 GOL  A 404 (-4.5A)
GOL  A 404 ( 3.1A)
None
None
None
GOL  A 404 ( 4.9A)
GOL  A 403 ( 3.0A)
 1.11A 4bkjA-4lg4A:
19.0		 4bkjA-4lg4A:
23.30
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4o27 SERINE/THREONINE-PRO
TEIN KINASE 24

(Homo sapiens) 		PF00069
(Pkinase) 		7 VAL B  38
ALA B  51
GLU B  70
TYR B 101
LEU B 151
ALA B 161
ASP B 162
 ADP  B 500 (-4.5A)
ADP  B 500 (-3.3A)
None
ADP  B 500 ( 4.7A)
ADP  B 500 (-4.7A)
None
ADP  B 500 ( 3.4A)
 1.05A 4bkjA-4o27B:
19.5		 4bkjA-4o27B:
26.50
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4p2k EPHRIN TYPE-A
RECEPTOR 2

(Homo sapiens) 		PF07714
(Pkinase_Tyr)
PF14575
(EphA2_TM) 		7 ALA A 644
GLU A 663
ILE A 666
ILE A 676
THR A 692
TYR A 694
ASP A 757
 None
 1.09A 4bkjA-4p2kA:
30.3		 4bkjA-4p2kA:
36.09
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4p2k EPHRIN TYPE-A
RECEPTOR 2

(Homo sapiens) 		PF07714
(Pkinase_Tyr)
PF14575
(EphA2_TM) 		7 ALA A 644
GLU A 663
MET A 667
ILE A 676
THR A 692
TYR A 694
ASP A 757
 None
 1.13A 4bkjA-4p2kA:
30.3		 4bkjA-4p2kA:
36.09
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4p2k EPHRIN TYPE-A
RECEPTOR 2

(Homo sapiens) 		PF07714
(Pkinase_Tyr)
PF14575
(EphA2_TM) 		7 VAL A 627
ALA A 644
MET A 667
ILE A 676
THR A 692
TYR A 694
ASP A 757
 None
 0.89A 4bkjA-4p2kA:
30.3		 4bkjA-4p2kA:
36.09
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4p2k EPHRIN TYPE-A
RECEPTOR 2

(Homo sapiens) 		PF07714
(Pkinase_Tyr)
PF14575
(EphA2_TM) 		7 VAL A 627
ALA A 644
MET A 667
ILE A 676
THR A 692
TYR A 694
LEU A 746
 None
 1.27A 4bkjA-4p2kA:
30.3		 4bkjA-4p2kA:
36.09
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4rew 5'-AMP-ACTIVATED
PROTEIN KINASE
CATALYTIC SUBUNIT
ALPHA-1

(Homo sapiens) 		PF00069
(Pkinase)
PF16579
(AdenylateSensor) 		6 ALA A  45
ILE A  79
MET A  93
TYR A  97
LEU A 148
ALA A 158
 STU  A 601 (-3.2A)
STU  A 601 ( 4.6A)
None
STU  A 601 (-4.4A)
STU  A 601 (-4.2A)
STU  A 601 ( 3.8A)
 0.88A 4bkjA-4rewA:
22.2		 4bkjA-4rewA:
19.86
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4rt7 RECEPTOR-TYPE
TYROSINE-PROTEIN
KINASE FLT3

(Homo sapiens) 		PF07714
(Pkinase_Tyr) 		7 VAL A 624
ALA A 642
GLU A 661
MET A 665
TYR A 693
LEU A 818
ASP A 829
 None
P30  A1001 (-3.4A)
P30  A1001 (-3.6A)
P30  A1001 ( 3.7A)
P30  A1001 (-4.1A)
P30  A1001 (-4.6A)
None
 0.96A 4bkjA-4rt7A:
29.0		 4bkjA-4rt7A:
28.10
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4ueu TYROSINE KINASE AS -
A COMMON ANCESTOR OF
SRC AND ABL

(synthetic
construct) 		PF07714
(Pkinase_Tyr) 		8 VAL A  22
ALA A  35
GLU A  52
ILE A  55
MET A  56
THR A  81
TYR A  83
ASP A 147
 ACP  A1264 (-4.7A)
ACP  A1264 (-2.9A)
None
None
None
ACP  A1264 (-4.5A)
ACP  A1264 ( 4.5A)
None
 1.01A 4bkjA-4ueuA:
29.8		 4bkjA-4ueuA:
39.81
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4ueu TYROSINE KINASE AS -
A COMMON ANCESTOR OF
SRC AND ABL

(synthetic
construct) 		PF07714
(Pkinase_Tyr) 		9 VAL A  22
ALA A  35
ILE A  55
MET A  56
THR A  81
TYR A  83
LEU A 136
ALA A 146
ASP A 147
 ACP  A1264 (-4.7A)
ACP  A1264 (-2.9A)
None
None
ACP  A1264 (-4.5A)
ACP  A1264 ( 4.5A)
ACP  A1264 ( 4.8A)
None
None
 1.07A 4bkjA-4ueuA:
29.8		 4bkjA-4ueuA:
39.81
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4xcu FIBROBLAST GROWTH
FACTOR RECEPTOR 4

(Homo sapiens) 		PF07714
(Pkinase_Tyr) 		7 VAL A 481
ALA A 501
GLU A 520
MET A 524
ILE A 534
LEU A 619
ALA A 629
 40M  A1002 ( 4.5A)
40M  A1002 ( 4.1A)
40M  A1002 (-3.7A)
40M  A1002 (-3.8A)
40M  A1002 (-4.0A)
40M  A1002 (-4.5A)
40M  A1002 (-3.0A)
 0.92A 4bkjA-4xcuA:
25.7		 4bkjA-4xcuA:
38.08
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4xuf RECEPTOR-TYPE
TYROSINE-PROTEIN
KINASE FLT3

(Homo sapiens) 		PF07714
(Pkinase_Tyr) 		7 VAL A 624
ALA A 642
GLU A 661
MET A 665
TYR A 693
LEU A 818
ASP A 829
 P30  A1001 ( 4.8A)
P30  A1001 (-3.5A)
P30  A1001 (-3.1A)
P30  A1001 (-4.4A)
P30  A1001 ( 4.4A)
P30  A1001 (-4.3A)
None
 1.04A 4bkjA-4xufA:
25.3		 4bkjA-4xufA:
33.44
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4yff SERINE/THREONINE-PRO
TEIN KINASE TNNI3K

(Homo sapiens) 		PF07714
(Pkinase_Tyr) 		9 VAL A 477
ALA A 488
GLU A 509
ILE A 512
ILE A 522
THR A 539
TYR A 541
LEU A 595
ALA A 605
 None
4CV  A 801 (-3.5A)
None
None
4CV  A 801 ( 4.2A)
4CV  A 801 (-2.8A)
4CV  A 801 (-3.9A)
4CV  A 801 (-4.4A)
4CV  A 801 ( 3.9A)
 0.82A 4bkjA-4yffA:
24.3		 4bkjA-4yffA:
29.55
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5a46 FIBROBLAST GROWTH
FACTOR RECEPTOR 1
(FMS-RELATED
TYROSINE KINASE 2,
PFEIFFER SYNDROME),
ISOFORM CRA_B

(Homo sapiens) 		PF07714
(Pkinase_Tyr) 		8 VAL A 492
ALA A 512
GLU A 531
MET A 535
ILE A 545
TYR A 563
LEU A 630
ALA A 640
 38O  A1769 (-4.5A)
38O  A1769 (-3.6A)
EDO  A1766 (-4.1A)
EDO  A1766 (-3.5A)
38O  A1769 ( 3.3A)
38O  A1769 (-4.2A)
38O  A1769 (-4.6A)
EDO  A1766 ( 4.4A)
 1.13A 4bkjA-5a46A:
30.5		 4bkjA-5a46A:
31.82
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5grn PLATELET-DERIVED
GROWTH FACTOR
RECEPTOR ALPHA

(Homo sapiens) 		PF07714
(Pkinase_Tyr) 		9 VAL A 607
ALA A 625
GLU A 644
ILE A 647
MET A 648
THR A 674
TYR A 676
LEU A 825
ASP A 836
 748  A1001 ( 4.7A)
748  A1001 (-3.7A)
748  A1001 (-3.3A)
748  A1001 ( 4.0A)
748  A1001 (-3.4A)
748  A1001 (-3.2A)
748  A1001 (-4.0A)
748  A1001 (-4.3A)
748  A1001 (-4.8A)
 0.97A 4bkjA-5grnA:
27.1		 4bkjA-5grnA:
30.59
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5gz8 PROTEIN O-MANNOSE
KINASE

(Mus musculus) 		PF07714
(Pkinase_Tyr) 		6 VAL A  94
ALA A 105
THR A 148
TYR A 150
LEU A 215
ASP A 226
 None
 0.77A 4bkjA-5gz8A:
18.5		 4bkjA-5gz8A:
22.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5idn CYCLIN-DEPENDENT
KINASE 8

(Homo sapiens) 		PF00069
(Pkinase) 		7 VAL A  35
ALA A  50
ILE A  79
TYR A  99
LEU A 158
ALA A 172
ASP A 173
 6A7  A 401 ( 4.5A)
6A7  A 401 (-3.3A)
6A7  A 401 (-4.2A)
6A7  A 401 (-4.9A)
6A7  A 401 (-4.8A)
6A7  A 401 ( 4.1A)
FMT  A 403 ( 3.3A)
 0.86A 4bkjA-5idnA:
20.6		 4bkjA-5idnA:
26.58
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5kbr SERINE/THREONINE-PRO
TEIN KINASE PAK 1

(Homo sapiens) 		PF00069
(Pkinase) 		7 VAL A 284
ALA A 297
GLU A 315
MET A 319
TYR A 346
LEU A 396
ASP A 407
 IPW  A 601 (-4.2A)
IPW  A 601 (-3.5A)
IPW  A 601 (-3.9A)
IPW  A 601 (-4.1A)
IPW  A 601 (-4.5A)
IPW  A 601 (-4.5A)
None
 1.15A 4bkjA-5kbrA:
21.1		 4bkjA-5kbrA:
23.82
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5l6o EPHRIN TYPE-B
RECEPTOR 3

(Homo sapiens) 		PF07714
(Pkinase_Tyr) 		8 VAL A 647
ALA A 663
ILE A 685
MET A 686
ILE A 695
THR A 711
LEU A 765
ASP A 776
 None
6P6  A1001 (-3.3A)
None
6P6  A1001 ( 4.2A)
None
6P6  A1001 (-3.5A)
6P6  A1001 (-4.5A)
None
 1.02A 4bkjA-5l6oA:
31.7		 4bkjA-5l6oA:
37.20
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5tvt MATERNAL EMBRYONIC
LEUCINE ZIPPER
KINASE

(Homo sapiens) 		no annotation 7 VAL A  25
ALA A  38
GLU A  57
MET A  84
TYR A  88
LEU A 139
ASP A 150
 7LV  A 401 ( 4.6A)
7LV  A 401 (-3.4A)
7LV  A 401 (-3.5A)
None
7LV  A 401 (-4.6A)
7LV  A 401 (-4.9A)
7LV  A 401 (-4.2A)
 1.22A 4bkjA-5tvtA:
22.0		 4bkjA-5tvtA:
23.12
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5xvu CASEIN KINASE 2,
ALPHA SUBUNIT

(Plasmodium
falciparum) 		PF00069
(Pkinase) 		6 VAL A  57
ALA A  70
GLU A  85
ILE A  88
ILE A  99
TYR A 119
 ATP  A 403 (-3.9A)
ATP  A 403 (-3.4A)
None
None
ATP  A 403 (-4.9A)
None
 0.76A 4bkjA-5xvuA:
19.9		 4bkjA-5xvuA:
19.30
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5y86 DUAL SPECIFICITY
TYROSINE-PHOSPHORYLA
TION-REGULATED
KINASE 3

(Homo sapiens) 		no annotation 7 VAL A 223
ALA A 236
GLU A 253
ILE A 256
ILE A 272
MET A 286
LEU A 342
 HRM  A 601 ( 4.9A)
HRM  A 601 (-3.5A)
HRM  A 601 ( 4.6A)
None
HRM  A 601 ( 4.8A)
None
None
 0.91A 4bkjA-5y86A:
19.7		 4bkjA-5y86A:
12.90
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6b3e CYCLIN-DEPENDENT
KINASE 12

(Homo sapiens) 		no annotation 7 VAL A 741
ALA A 754
GLU A 774
ILE A 777
TYR A 815
LEU A 866
ALA A 876
 None
CJM  A1102 (-3.1A)
None
None
CJM  A1102 (-4.1A)
CJM  A1102 (-4.4A)
CJM  A1102 (-3.6A)
 0.64A 4bkjA-6b3eA:
22.5		 4bkjA-6b3eA:
15.04
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6b4w DUAL SPECIFICITY
PROTEIN KINASE TTK

(Homo sapiens) 		no annotation 6 VAL A 539
ALA A 551
ILE A 586
MET A 600
LEU A 654
ASP A 664
 CQ7  A 801 ( 4.8A)
CQ7  A 801 (-3.2A)
CQ7  A 801 ( 4.5A)
None
CQ7  A 801 (-4.5A)
None
 0.71A 4bkjA-6b4wA:
23.3		 4bkjA-6b4wA:
22.65
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6bx6 5'-AMP-ACTIVATED
PROTEIN KINASE
CATALYTIC SUBUNIT
ALPHA-2

(Homo sapiens) 		no annotation 7 VAL A  30
ALA A  43
ILE A  77
MET A  91
TYR A  95
LEU A 146
ALA A 156
 None
EDJ  A 301 (-3.4A)
EDJ  A 301 ( 4.7A)
None
EDJ  A 301 ( 4.8A)
EDJ  A 301 ( 4.5A)
EDJ  A 301 (-3.2A)
 1.12A 4bkjA-6bx6A:
18.7		 4bkjA-6bx6A:
16.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6c9d SERINE/THREONINE-PRO
TEIN KINASE
MARK1,SERINE/THREONI
NE-PROTEIN KINASE
MARK1

(Homo sapiens) 		no annotation 8 VAL A  74
ALA A  87
GLU A 107
ILE A 110
MET A 111
TYR A 138
LEU A 189
ALA A 199
 None
 1.36A 4bkjA-6c9dA:
21.0		 4bkjA-6c9dA:
11.78