SIMILAR PATTERNS OF AMINO ACIDS FOR 4BBO_C_ACTC1113_0

List of similar pattern of amino acids derived from ASSAM search

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click link on the last column to view superposed patterns of amino acids in NGL viewer)
(Note that only 3-12 residue patterns can be used for ASSAM searches)
Filter list by:
Hit Macromolecule/
Organism		 Pfam Res. Interface HETATM RMSD Dali Z-score Seq. Identity (%) View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1btc BETA-AMYLASE

(Glycine max) 		PF01373
(Glyco_hydro_14) 		4 ASN A 340
ALA A 378
GLY A 379
THR A 417
 None
 1.29A 4bboC-1btcA:
0.0		 4bboC-1btcA:
13.84
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1c3r HDLP (HISTONE
DEACETYLASE-LIKE
PROTEIN)

(Aquifex
aeolicus) 		PF00850
(Hist_deacetyl) 		4 ASN A 125
ALA A 127
GLY A 128
THR A 107
 None
 1.38A 4bboC-1c3rA:
0.0		 4bboC-1c3rA:
17.51
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ebp EPO RECEPTOR

(Homo sapiens) 		PF00041
(fn3)
PF09067
(EpoR_lig-bind) 		4 ASN A 164
ALA A 166
GLY A 163
THR A 190
 None
 1.00A 4bboC-1ebpA:
0.0		 4bboC-1ebpA:
17.70
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1gpj GLUTAMYL-TRNA
REDUCTASE

(Methanopyrus
kandleri) 		PF00745
(GlutR_dimer)
PF01488
(Shikimate_DH)
PF05201
(GlutR_N) 		4 ASN A 198
ALA A 175
GLY A 174
THR A 235
 None
 1.39A 4bboC-1gpjA:
undetectable		 4bboC-1gpjA:
12.12
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1itz TRANSKETOLASE

(Zea mays) 		PF00456
(Transketolase_N)
PF02779
(Transket_pyr)
PF02780
(Transketolase_C) 		4 ASN A  60
ALA A 316
GLY A 315
THR A 312
 None
 1.13A 4bboC-1itzA:
0.0		 4bboC-1itzA:
11.86
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1kcv PC282 IMMUNOGLOBULIN

(Mus musculus) 		PF07654
(C1-set)
PF07686
(V-set) 		4 ASN L  28
ALA L  68
GLY L  30
THR L  31
 None
 1.24A 4bboC-1kcvL:
0.0		 4bboC-1kcvL:
18.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1kyh HYPOTHETICAL 29.9
KDA PROTEIN IN
SIGY-CYDD INTERGENIC
REGION

(Bacillus
subtilis) 		PF01256
(Carb_kinase) 		4 ASN A 206
ALA A 247
GLY A 205
THR A 204
 None
 1.34A 4bboC-1kyhA:
0.0		 4bboC-1kyhA:
18.18
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1mw7 HYPOTHETICAL PROTEIN
HP0162

(Helicobacter
pylori) 		PF01709
(Transcrip_reg) 		4 ASN A  88
ALA A  87
GLY A 118
THR A 116
 None
 1.09A 4bboC-1mw7A:
0.0		 4bboC-1mw7A:
19.15
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1nrw HYPOTHETICAL
PROTEIN, HALOACID
DEHALOGENASE-LIKE
HYDROLASE

(Bacillus
subtilis) 		PF08282
(Hydrolase_3) 		4 ASN A 256
ALA A 257
GLY A 255
THR A 269
 None
 1.14A 4bboC-1nrwA:
undetectable		 4bboC-1nrwA:
19.10
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1prz RIBOSOMAL LARGE
SUBUNIT
PSEUDOURIDINE
SYNTHASE D

(Escherichia
coli) 		PF00849
(PseudoU_synth_2) 		4 ASN A  97
ALA A 299
GLY A 144
THR A 143
 None
 1.17A 4bboC-1przA:
undetectable		 4bboC-1przA:
16.19
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1q14 HST2 PROTEIN

(Saccharomyces
cerevisiae) 		PF02146
(SIR2) 		4 ASN A 116
ALA A  33
GLY A  32
THR A 224
 None
 1.29A 4bboC-1q14A:
undetectable		 4bboC-1q14A:
15.32
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1q1a HST2 PROTEIN

(Saccharomyces
cerevisiae) 		PF02146
(SIR2) 		4 ASN A 116
ALA A  33
GLY A  32
THR A 224
 None
OAD  A1001 (-3.9A)
OAD  A1001 (-3.2A)
OAD  A1001 (-3.8A)
 1.26A 4bboC-1q1aA:
undetectable		 4bboC-1q1aA:
17.59
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1q8i DNA POLYMERASE II

(Escherichia
coli) 		PF00136
(DNA_pol_B)
PF03104
(DNA_pol_B_exo1) 		4 ASN A 359
ALA A 356
GLY A 360
THR A 121
 None
 1.24A 4bboC-1q8iA:
undetectable		 4bboC-1q8iA:
8.85
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1qo8 FLAVOCYTOCHROME C3
FUMARATE REDUCTASE

(Shewanella
frigidimarina) 		PF00890
(FAD_binding_2)
PF14537
(Cytochrom_c3_2) 		4 ASN A 332
ALA A 336
GLY A 312
THR A 501
 FAD  A 605 (-4.2A)
None
None
None
 1.27A 4bboC-1qo8A:
undetectable		 4bboC-1qo8A:
13.11
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1t9k PROBABLE
METHYLTHIORIBOSE-1-P
HOSPHATE ISOMERASE

(Thermotoga
maritima) 		PF01008
(IF-2B) 		4 ASN A 155
ALA A 160
GLY A 157
THR A 166
 None
 1.07A 4bboC-1t9kA:
undetectable		 4bboC-1t9kA:
15.12
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1v6y ENDO-1,4-BETA-D-XYLA
NASE AND
ENDO-1,4-BETA-XYLANA
SE B

(Cellulomonas
fimi;
Streptomyces
olivaceoviridis) 		PF00331
(Glyco_hydro_10) 		4 ASN A  39
ALA A  10
GLY A   6
THR A   4
 None
 1.34A 4bboC-1v6yA:
undetectable		 4bboC-1v6yA:
18.42
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1w2w 5-METHYLTHIORIBOSE-1
-PHOSPHATE ISOMERASE

(Saccharomyces
cerevisiae) 		PF01008
(IF-2B) 		4 ASN A 182
ALA A 187
GLY A 184
THR A 193
 None
 1.11A 4bboC-1w2wA:
undetectable		 4bboC-1w2wA:
19.25
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1w99 PESTICIDIAL CRYSTAL
PROTEIN CRY4BA

(Bacillus
thuringiensis) 		PF00555
(Endotoxin_M)
PF03944
(Endotoxin_C)
PF03945
(Endotoxin_N) 		4 ASN A 492
ALA A 495
GLY A 519
THR A 512
 BR  A1649 (-4.3A)
None
None
None
 1.16A 4bboC-1w99A:
undetectable		 4bboC-1w99A:
12.04
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1wsv AMINOMETHYLTRANSFERA
SE

(Homo sapiens) 		PF01571
(GCV_T)
PF08669
(GCV_T_C) 		4 ASN A  93
ALA A  95
GLY A  96
THR A 254
 ASN  A  93 ( 0.6A)
ALA  A  95 ( 0.0A)
GLY  A  96 ( 0.0A)
THR  A 254 ( 0.8A)
 1.16A 4bboC-1wsvA:
undetectable		 4bboC-1wsvA:
14.29
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1wsv AMINOMETHYLTRANSFERA
SE

(Homo sapiens) 		PF01571
(GCV_T)
PF08669
(GCV_T_C) 		4 ASN A  93
ALA A  95
GLY A  97
THR A 254
 ASN  A  93 ( 0.6A)
ALA  A  95 ( 0.0A)
GLY  A  97 ( 0.0A)
THR  A 254 ( 0.8A)
 1.39A 4bboC-1wsvA:
undetectable		 4bboC-1wsvA:
14.29
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2b8n GLYCERATE KINASE,
PUTATIVE

(Thermotoga
maritima) 		PF05161
(MOFRL)
PF13660
(DUF4147) 		4 ASN A 326
ALA A 348
GLY A 349
THR A 350
 None
 1.21A 4bboC-2b8nA:
undetectable		 4bboC-2b8nA:
13.37
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2d4y FLAGELLAR
HOOK-ASSOCIATED
PROTEIN 1

(Salmonella
enterica) 		no annotation 4 ASN A 454
ALA A 434
GLY A 315
THR A 313
 None
 1.04A 4bboC-2d4yA:
undetectable		 4bboC-2d4yA:
14.93
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2d7i POLYPEPTIDE
N-ACETYLGALACTOSAMIN
YLTRANSFERASE 10

(Homo sapiens) 		PF00535
(Glycos_transf_2)
PF00652
(Ricin_B_lectin) 		4 ASN A 146
ALA A 178
GLY A 230
THR A 229
 NAG  A 704 (-2.3A)
NAG  A 704 (-3.3A)
NAG  A 704 ( 4.9A)
NAG  A 704 ( 4.8A)
 1.05A 4bboC-2d7iA:
undetectable		 4bboC-2d7iA:
13.80
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2fb5 HYPOTHETICAL
MEMBRANE SPANNING
PROTEIN

(Bacillus cereus) 		PF02457
(DisA_N)
PF10372
(YojJ) 		4 ASN A 150
ALA A 149
GLY A 111
THR A 112
 None
 1.17A 4bboC-2fb5A:
undetectable		 4bboC-2fb5A:
18.35
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2hjh NAD-DEPENDENT
HISTONE DEACETYLASE
SIR2

(Saccharomyces
cerevisiae) 		PF02146
(SIR2)
PF04574
(DUF592) 		4 ASN A 345
ALA A 263
GLY A 262
THR A 472
 None
XYQ  A1222 (-3.4A)
XYQ  A1222 (-3.4A)
XYQ  A1222 (-3.7A)
 1.28A 4bboC-2hjhA:
undetectable		 4bboC-2hjhA:
14.41
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2ist RIBOSOMAL LARGE
SUBUNIT
PSEUDOURIDINE
SYNTHASE D

(Escherichia
coli) 		PF00849
(PseudoU_synth_2)
PF01479
(S4) 		4 ASN A  97
ALA A 299
GLY A 144
THR A 143
 None
 1.14A 4bboC-2istA:
undetectable		 4bboC-2istA:
14.51
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2jll NEURAL CELL ADHESION
MOLECULE 2

(Homo sapiens) 		PF00041
(fn3)
PF07679
(I-set)
PF13927
(Ig_3) 		4 ASN A 479
ALA A 400
GLY A 482
THR A 483
 None
 1.38A 4bboC-2jllA:
undetectable		 4bboC-2jllA:
14.65
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2o1t ENDOPLASMIN

(Canis lupus) 		PF00183
(HSP90) 		4 ASN A 657
ALA A 542
GLY A 543
THR A 569
 None
 1.22A 4bboC-2o1tA:
undetectable		 4bboC-2o1tA:
13.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2o1v ENDOPLASMIN

(Canis lupus) 		PF00183
(HSP90)
PF02518
(HATPase_c) 		4 ASN A 657
ALA A 542
GLY A 543
THR A 569
 None
 1.22A 4bboC-2o1vA:
undetectable		 4bboC-2o1vA:
10.53
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2vdc GLUTAMATE SYNTHASE
[NADPH] LARGE CHAIN

(Azospirillum
brasilense) 		PF00310
(GATase_2)
PF01493
(GXGXG)
PF01645
(Glu_synthase)
PF04898
(Glu_syn_central) 		4 ASN A1350
ALA A1353
GLY A1371
THR A1372
 None
 1.18A 4bboC-2vdcA:
undetectable		 4bboC-2vdcA:
5.91
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2wmc EUKARYOTIC
TRANSLATION
INITIATION FACTOR 4E

(Pisum sativum) 		PF01652
(IF4E) 		4 ASN A 128
ALA A 184
GLY A 129
THR A 181
 None
 1.36A 4bboC-2wmcA:
undetectable		 4bboC-2wmcA:
23.70
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2y32 BLR5658 PROTEIN

(Bradyrhizobium
japonicum) 		PF01382
(Avidin) 		4 ASN A  80
ALA A  82
GLY A  84
THR A 110
 None
 0.21A 4bboC-2y32A:
19.5		 4bboC-2y32A:
100.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2yue PROTEIN NEURALIZED

(Drosophila
melanogaster) 		PF07177
(Neuralized) 		4 ASN A 117
ALA A 119
GLY A 120
THR A 136
 None
 1.09A 4bboC-2yueA:
undetectable		 4bboC-2yueA:
20.12
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3a8u OMEGA-AMINO
ACID--PYRUVATE
AMINOTRANSFERASE

(Pseudomonas
putida) 		PF00202
(Aminotran_3) 		4 ASN X 292
ALA X  64
GLY X  63
THR X 425
 None
 1.18A 4bboC-3a8uX:
undetectable		 4bboC-3a8uX:
15.37
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3att PUTATIVE
UNCHARACTERIZED
PROTEIN

(Mycobacterium
tuberculosis) 		PF01636
(APH) 		4 ASN A 152
ALA A 155
GLY A 150
THR A 148
 None
 1.13A 4bboC-3attA:
undetectable		 4bboC-3attA:
15.06
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ctt MALTASE-GLUCOAMYLASE

(Homo sapiens) 		PF00088
(Trefoil)
PF01055
(Glyco_hydro_31)
PF16863
(NtCtMGAM_N) 		4 ASN A 201
ALA A 216
GLY A 215
THR A 528
 None
 1.29A 4bboC-3cttA:
undetectable		 4bboC-3cttA:
9.04
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3dt8 BRAIN
PLATELET-ACTIVATING
FACTOR
ACETYLHYDROLASE IB
SUBUNIT ALPHA

(Bos taurus) 		PF13472
(Lipase_GDSL_2) 		4 ASN A   6
ALA A   8
GLY A 115
THR A 114
 None
 1.20A 4bboC-3dt8A:
undetectable		 4bboC-3dt8A:
20.10
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ewl UNCHARACTERIZED
CONSERVED PROTEIN
BF1870

(Bacteroides
fragilis) 		PF13098
(Thioredoxin_2) 		4 ASN A  91
ALA A  93
GLY A  94
THR A  98
 None
 1.38A 4bboC-3ewlA:
undetectable		 4bboC-3ewlA:
17.39
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3gbp GALACTOSE-BINDING
PROTEIN

(Salmonella
enterica) 		PF13407
(Peripla_BP_4) 		4 ASN A 210
ALA A 155
GLY A 148
THR A 180
 None
 1.35A 4bboC-3gbpA:
undetectable		 4bboC-3gbpA:
17.97
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3hum PENICILLIN-BINDING
PROTEIN 4

(Staphylococcus
aureus) 		PF00768
(Peptidase_S11)
PF09211
(DUF1958) 		4 ASN A 269
ALA A 266
GLY A 287
THR A  50
 None
 1.18A 4bboC-3humA:
undetectable		 4bboC-3humA:
15.19
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3i09 PERIPLASMIC
BRANCHED-CHAIN AMINO
ACID-BINDING PROTEIN

(Burkholderia
mallei) 		PF13458
(Peripla_BP_6) 		4 ASN A 123
ALA A 107
GLY A 101
THR A 102
 None
None
None
AAE  A 501 (-4.0A)
 1.19A 4bboC-3i09A:
undetectable		 4bboC-3i09A:
14.21
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3l5a NADH/FLAVIN
OXIDOREDUCTASE/NADH
OXIDASE

(Staphylococcus
aureus) 		PF00724
(Oxidored_FMN) 		4 ASN A 186
ALA A 194
GLY A 193
THR A 189
 None
 0.90A 4bboC-3l5aA:
undetectable		 4bboC-3l5aA:
15.57
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3m19 VARIABLE LYMPHOCYTE
RECEPTOR A DIVERSITY
REGION

(Petromyzon
marinus) 		PF13855
(LRR_8) 		4 ASN A  91
ALA A  90
GLY A 115
THR A 139
 None
 1.34A 4bboC-3m19A:
undetectable		 4bboC-3m19A:
18.52
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3n6x PUTATIVE
GLUTATHIONYLSPERMIDI
NE SYNTHASE

(Methylobacillus
flagellatus) 		PF14403
(CP_ATPgrasp_2) 		4 ASN A 205
ALA A 208
GLY A 435
THR A 437
 None
GOL  A 495 ( 4.0A)
GOL  A 484 (-4.8A)
None
 1.19A 4bboC-3n6xA:
undetectable		 4bboC-3n6xA:
13.80
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3niw HALOACID
DEHALOGENASE-LIKE
HYDROLASE

(Bacteroides
thetaiotaomicron) 		PF08282
(Hydrolase_3) 		4 ASN A 238
ALA A 239
GLY A 237
THR A 251
 None
 1.15A 4bboC-3niwA:
undetectable		 4bboC-3niwA:
16.42
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3nwn KINESIN-LIKE PROTEIN
KIF9

(Homo sapiens) 		PF00225
(Kinesin) 		4 ASN A 269
ALA A 247
GLY A 248
THR A  95
 None
None
None
ADP  A 401 (-4.0A)
 1.27A 4bboC-3nwnA:
undetectable		 4bboC-3nwnA:
16.20
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3o5d PEPTIDYL-PROLYL
CIS-TRANS ISOMERASE
FKBP5

(Homo sapiens) 		PF00254
(FKBP_C) 		4 ASN A 163
ALA A 253
GLY A 165
THR A 167
 None
 1.35A 4bboC-3o5dA:
undetectable		 4bboC-3o5dA:
18.99
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3phg SHIKIMATE
DEHYDROGENASE

(Helicobacter
pylori) 		PF08501
(Shikimate_dh_N) 		4 ASN A 148
ALA A 126
GLY A 125
THR A 180
 None
 1.33A 4bboC-3phgA:
undetectable		 4bboC-3phgA:
16.67
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3pkj NAD-DEPENDENT
DEACETYLASE
SIRTUIN-6

(Homo sapiens) 		PF02146
(SIR2) 		4 ASN A 112
ALA A  51
GLY A  50
THR A 213
 None
A2N  A1000 (-3.5A)
A2N  A1000 (-3.2A)
A2N  A1000 (-3.8A)
 1.22A 4bboC-3pkjA:
undetectable		 4bboC-3pkjA:
15.67
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3q9c ACETYLPOLYAMINE
AMIDOHYDROLASE

(Mycoplana
ramosa) 		PF00850
(Hist_deacetyl) 		4 ASN A 200
ALA A 159
GLY A 201
THR A 202
 None
 1.21A 4bboC-3q9cA:
undetectable		 4bboC-3q9cA:
15.50
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3r5z PUTATIVE
UNCHARACTERIZED
PROTEIN

(Nocardia
farcinica) 		PF04075
(F420H2_quin_red) 		4 ASN A  83
ALA A  46
GLY A  45
THR A  48
 F42  A 201 (-3.3A)
F42  A 201 (-3.7A)
F42  A 201 (-3.6A)
F42  A 201 (-2.8A)
 1.09A 4bboC-3r5zA:
undetectable		 4bboC-3r5zA:
21.43
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3tbh O-ACETYL SERINE
SULFHYDRYLASE

(Leishmania
donovani) 		PF00291
(PALP) 		4 ASN A 158
ALA A 159
GLY A 189
THR A 190
 LLP  A  51 ( 4.9A)
None
LLP  A  51 ( 3.8A)
LLP  A  51 ( 3.7A)
 1.38A 4bboC-3tbhA:
undetectable		 4bboC-3tbhA:
17.46
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3uyw HEMAGGLUTININ

(Influenza A
virus) 		PF00509
(Hemagglutinin) 		4 ASN A  62
ALA A  64
GLY A  65
THR A  95
 None
 1.29A 4bboC-3uywA:
undetectable		 4bboC-3uywA:
18.32
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3vrb FLAVOPROTEIN SUBUNIT
OF COMPLEX II

(Ascaris suum) 		PF00890
(FAD_binding_2)
PF02910
(Succ_DH_flav_C) 		4 ASN A 555
ALA A 258
GLY A 254
THR A 253
 None
 1.39A 4bboC-3vrbA:
undetectable		 4bboC-3vrbA:
10.95
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3zg6 NAD-DEPENDENT
PROTEIN DEACETYLASE
SIRTUIN-6

(Homo sapiens) 		PF02146
(SIR2) 		4 ASN A 112
ALA A  51
GLY A  50
THR A 213
 None
APR  A1296 (-3.7A)
APR  A1296 (-3.2A)
APR  A1296 (-3.7A)
 1.20A 4bboC-3zg6A:
undetectable		 4bboC-3zg6A:
17.53
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4b98 BETA-ALANINE--PYRUVA
TE TRANSAMINASE

(Pseudomonas
aeruginosa) 		PF00202
(Aminotran_3) 		4 ASN A 292
ALA A  65
GLY A  64
THR A 425
 None
 1.19A 4bboC-4b98A:
undetectable		 4bboC-4b98A:
14.25
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4b9y ALPHA-GLUCOSIDASE,
PUTATIVE, ADG31B

(Cellvibrio
japonicus) 		PF01055
(Glyco_hydro_31)
PF13802
(Gal_mutarotas_2)
PF16338
(DUF4968)
PF17137
(DUF5110) 		4 ASN A 207
ALA A 227
GLY A 230
THR A 432
 None
None
EDO  A1829 (-3.4A)
EDO  A1829 (-3.8A)
 1.36A 4bboC-4b9yA:
undetectable		 4bboC-4b9yA:
9.00
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4bbo BLR5658 PROTEIN

(Bradyrhizobium
japonicum) 		PF01382
(Avidin) 		4 ASN A  80
ALA A  82
GLY A  84
THR A 110
 None
 0.21A 4bboC-4bboA:
23.3		 4bboC-4bboA:
100.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4bn5 NAD-DEPENDENT
PROTEIN DEACETYLASE
SIRTUIN-3,
MITOCHONDRIAL

(Homo sapiens) 		PF02146
(SIR2) 		4 ASN A 229
ALA A 146
GLY A 145
THR A 320
 CNA  A1395 (-3.7A)
CNA  A1395 (-3.1A)
CNA  A1395 ( 3.7A)
CNA  A1395 (-4.2A)
 1.38A 4bboC-4bn5A:
undetectable		 4bboC-4bn5A:
18.75
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4g1c NAD-DEPENDENT
PROTEIN DEACYLASE
SIRTUIN-5,
MITOCHONDRIAL

(Homo sapiens) 		PF02146
(SIR2) 		4 ASN A 141
ALA A  59
GLY A  58
THR A 250
 CNA  A 402 (-4.1A)
CNA  A 402 (-3.0A)
CNA  A 402 ( 3.8A)
CNA  A 402 (-4.3A)
 1.29A 4bboC-4g1cA:
undetectable		 4bboC-4g1cA:
18.80
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ghb HYPOTHETICAL PROTEIN

(Bacteroides
uniformis) 		PF15283
(DUF4595) 		4 ASN A  87
ALA A  89
GLY A  90
THR A  59
 SO4  A 402 (-4.5A)
None
GOL  A 412 (-3.5A)
GOL  A 412 ( 3.9A)
 1.26A 4bboC-4ghbA:
undetectable		 4bboC-4ghbA:
21.70
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4i4n INTRACELLULAR
PROTEASE/AMIDASE

(Vibrio cholerae) 		no annotation 4 ASN A  75
ALA A  58
GLY A  57
THR A  98
 None
 1.26A 4bboC-4i4nA:
undetectable		 4bboC-4i4nA:
17.75
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4iao NAD-DEPENDENT
HISTONE DEACETYLASE
SIR2

(Saccharomyces
cerevisiae) 		PF02146
(SIR2)
PF04574
(DUF592) 		4 ASN A 345
ALA A 263
GLY A 262
THR A 472
 None
APR  A 602 (-3.3A)
APR  A 602 (-3.1A)
APR  A 602 (-4.0A)
 1.27A 4bboC-4iaoA:
undetectable		 4bboC-4iaoA:
11.23
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4jug HEMAGGLUTININ

(Influenza A
virus) 		PF00509
(Hemagglutinin) 		4 ASN A  60
ALA A  62
GLY A  63
THR A  93
 None
 1.36A 4bboC-4jugA:
undetectable		 4bboC-4jugA:
15.43
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4jug HEMAGGLUTININ

(Influenza A
virus) 		PF00509
(Hemagglutinin) 		4 ASN A  60
ALA A  62
GLY A  92
THR A  93
 None
 0.85A 4bboC-4jugA:
undetectable		 4bboC-4jugA:
15.43
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4kvs ALDEHYDE
DECARBONYLASE

(Prochlorococcus
marinus) 		PF11266
(Ald_deCOase) 		4 ASN A  38
ALA A  91
GLY A  84
THR A  81
 None
 1.17A 4bboC-4kvsA:
undetectable		 4bboC-4kvsA:
18.60
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ldq METHYLTHIORIBOSE-1-P
HOSPHATE ISOMERASE

(Homo sapiens) 		PF01008
(IF-2B) 		4 ASN A 169
ALA A 174
GLY A 171
THR A 180
 None
 1.04A 4bboC-4ldqA:
undetectable		 4bboC-4ldqA:
15.10
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4mfz DBV8 PROTEIN

(Nonomuraea
gerenzanensis) 		no annotation 4 ASN A 182
ALA A 184
GLY A 194
THR A 233
 None
 0.94A 4bboC-4mfzA:
undetectable		 4bboC-4mfzA:
15.34
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4oye 425AA LONG
HYPOTHETICAL PROTON
GLUTAMATE SYMPORT
PROTEIN

(Pyrococcus
horikoshii) 		PF00375
(SDF) 		4 ASN A 401
ALA A 397
GLY A 313
THR A 314
 None
 1.15A 4bboC-4oyeA:
undetectable		 4bboC-4oyeA:
14.89
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4qji PHOSPHOPANTOTHENOYLC
YSTEINE
DECARBOXYLASE/PHOSPH
OPANTOTHENATE--CYSTE
INE LIGASE

(Mycolicibacterium
smegmatis) 		PF04127
(DFP) 		4 ASN A 211
ALA A 278
GLY A 198
THR A 199
 None
 1.26A 4bboC-4qjiA:
undetectable		 4bboC-4qjiA:
18.94
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4qnl TAIL FIBER PROTEIN

(Escherichia
virus G7C) 		no annotation 4 ASN A 757
ALA A 759
GLY A 760
THR A 781
 None
 0.99A 4bboC-4qnlA:
undetectable		 4bboC-4qnlA:
10.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4r7u UDP-N-ACETYLGLUCOSAM
INE
1-CARBOXYVINYLTRANSF
ERASE

(Vibrio cholerae) 		PF00275
(EPSP_synthase) 		4 ASN A 315
ALA A 292
GLY A 322
THR A 294
 None
NA  A 504 ( 4.5A)
None
None
 1.35A 4bboC-4r7uA:
undetectable		 4bboC-4r7uA:
15.25
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4rya ABC TRANSPORTER
SUBSTRATE BINDING
PROTEIN (SORBITOL)

(Agrobacterium
vitis) 		PF01547
(SBP_bac_1) 		4 ASN A 192
ALA A 187
GLY A 403
THR A 400
 None
 1.05A 4bboC-4ryaA:
undetectable		 4bboC-4ryaA:
15.48
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4twi NAD-DEPENDENT
PROTEIN DEACYLASE 1

(Archaeoglobus
fulgidus) 		PF02146
(SIR2) 		4 ASN A  99
ALA A  21
GLY A  20
THR A 186
 None
 1.24A 4bboC-4twiA:
undetectable		 4bboC-4twiA:
17.62
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4uhm OMEGA AMINO
ACID-PYRUVATE
AMINOTRANSFERASE

(Pseudomonas sp.) 		PF00202
(Aminotran_3) 		4 ASN A 292
ALA A  65
GLY A  64
THR A 425
 None
 1.18A 4bboC-4uhmA:
undetectable		 4bboC-4uhmA:
15.12
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4xdt FAD:PROTEIN FMN
TRANSFERASE

(Treponema
pallidum) 		PF02424
(ApbE) 		4 ASN A 191
ALA A 169
GLY A 166
THR A 281
 None
 1.25A 4bboC-4xdtA:
undetectable		 4bboC-4xdtA:
14.37
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4y6o NAD-DEPENDENT
PROTEIN DEACETYLASE
SIRTUIN-2

(Homo sapiens) 		PF02146
(SIR2) 		4 ASN A 168
ALA A  85
GLY A  84
THR A 262
 None
 1.27A 4bboC-4y6oA:
undetectable		 4bboC-4y6oA:
17.29
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ypj BETA GALACTOSIDASE

(Bacillus
circulans) 		PF00703
(Glyco_hydro_2)
PF02836
(Glyco_hydro_2_C)
PF02837
(Glyco_hydro_2_N)
PF16355
(DUF4982) 		4 ASN A 453
ALA A 455
GLY A 456
THR A 459
 None
 1.32A 4bboC-4ypjA:
undetectable		 4bboC-4ypjA:
9.91
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4z64 PHYTOSULFOKINE
RECEPTOR 1

(Arabidopsis
thaliana) 		PF00560
(LRR_1)
PF08263
(LRRNT_2)
PF13855
(LRR_8) 		4 ASN A 346
ALA A 348
GLY A 324
THR A 325
 None
 0.88A 4bboC-4z64A:
undetectable		 4bboC-4z64A:
11.56
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5c1e PECTINESTERASE

(Aspergillus
niger) 		PF01095
(Pectinesterase) 		4 ASN A 207
ALA A 187
GLY A 186
THR A 169
 None
 1.33A 4bboC-5c1eA:
undetectable		 4bboC-5c1eA:
18.82
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5c3m PUTATIVE
6-PHOSPHO-BETA-GLUCO
SIDASE

(Geobacillus
stearothermophilus) 		PF02056
(Glyco_hydro_4)
PF11975
(Glyco_hydro_4C) 		4 ASN A 201
ALA A 152
GLY A 153
THR A 156
 MN  A 501 (-3.5A)
MN  A 501 ( 4.7A)
None
None
 1.28A 4bboC-5c3mA:
undetectable		 4bboC-5c3mA:
12.88
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5cwl DESIGNED HELICAL
REPEAT PROTEIN

(synthetic
construct) 		no annotation 4 ASN A  68
ALA A  21
GLY A  24
THR A  26
 None
 1.36A 4bboC-5cwlA:
undetectable		 4bboC-5cwlA:
17.11
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5e7g IPT/TIG
DOMAIN-CONTAINING
PROTEIN BACOVA_02650

(Bacteroides
ovatus) 		no annotation 4 ASN A 469
ALA A 475
GLY A 403
THR A 402
 None
 1.35A 4bboC-5e7gA:
undetectable		 4bboC-5e7gA:
14.82
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5e7h IPT/TIG
DOMAIN-CONTAINING
PROTEIN BACOVA_02650

(Bacteroides
ovatus) 		PF01833
(TIG) 		4 ASN A 469
ALA A 475
GLY A 403
THR A 402
 None
 1.31A 4bboC-5e7hA:
undetectable		 4bboC-5e7hA:
22.27
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5efn HDAC6 PROTEIN

(Danio rerio) 		no annotation 4 ASN B 617
ALA B 574
GLY B 618
THR B 619
 None
 1.17A 4bboC-5efnB:
undetectable		 4bboC-5efnB:
15.26
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5fhy B-TYPE FLAGELLAR
HOOK-ASSOCIATED
PROTEIN 2

(Pseudomonas
aeruginosa) 		PF07195
(FliD_C)
PF07196
(Flagellin_IN) 		4 ASN A 231
ALA A 244
GLY A 184
THR A 183
 None
 1.24A 4bboC-5fhyA:
undetectable		 4bboC-5fhyA:
19.87
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5fyq NAD-DEPENDENT
PROTEIN DEACETYLASE
SIRTUIN-2

(Homo sapiens) 		PF02146
(SIR2) 		4 ASN A 168
ALA A  85
GLY A  84
THR A 262
 None
SO4  A1357 ( 4.1A)
SO4  A1357 ( 4.3A)
SO4  A1357 (-3.5A)
 1.32A 4bboC-5fyqA:
undetectable		 4bboC-5fyqA:
15.56
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5iml NANOBODY

(Camelidae) 		PF07686
(V-set) 		4 ASN B  76
ALA B  23
GLY B  25
THR B  27
 None
 1.39A 4bboC-5imlB:
undetectable		 4bboC-5imlB:
21.21
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5m60 BETA-1,3-GLUCANASE

(Chaetomium
thermophilum) 		PF12708
(Pectate_lyase_3) 		4 ASN A 262
ALA A 264
GLY A 292
THR A 322
 None
 1.23A 4bboC-5m60A:
undetectable		 4bboC-5m60A:
12.19
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5mih PA-I GALACTOPHILIC
LECTIN

(Pseudomonas
aeruginosa) 		no annotation 4 ASN A  10
ALA A  12
GLY A  13
THR A  95
 None
 1.27A 4bboC-5mihA:
undetectable		 4bboC-5mihA:
24.09
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5mjs TUBULIN BETA CHAIN

(Schizosaccharomyces
pombe) 		no annotation 4 ASN A  14
ALA A   9
GLY A  13
THR A 136
 None
 1.34A 4bboC-5mjsA:
undetectable		 4bboC-5mjsA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ol0 PUTATIVE SILENT
INFORMATION
REGULATOR 2,PUTATIVE
SILENT INFORMATION
REGULATOR 2

(Leishmania
infantum) 		no annotation 4 ASN A 125
ALA A  40
GLY A  39
THR A 217
 None
 1.13A 4bboC-5ol0A:
undetectable		 4bboC-5ol0A:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ov3 RETINOBLASTOMA-BINDI
NG PROTEIN 5

(Mus musculus) 		no annotation 4 ASN A 170
ALA A 171
GLY A 173
THR A 198
 None
 1.02A 4bboC-5ov3A:
undetectable		 4bboC-5ov3A:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ty7 PENICILLIN-BINDING
PROTEIN 4

(Staphylococcus
aureus) 		no annotation 4 ASN A 269
ALA A 266
GLY A 287
THR A  50
 None
 1.12A 4bboC-5ty7A:
undetectable		 4bboC-5ty7A:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5w19 TRYPTOPHANASE

(Proteus
vulgaris) 		no annotation 4 ASN A  77
ALA A 310
GLY A  68
THR A  67
 None
 0.91A 4bboC-5w19A:
undetectable		 4bboC-5w19A:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6bv2 AMINOPEPTIDASE N

(Sus scrofa) 		no annotation 4 ASN A 861
ALA A 864
GLY A 901
THR A 903
 None
 1.33A 4bboC-6bv2A:
undetectable		 4bboC-6bv2A:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6czs -

(-) 		no annotation 4 ASN A 320
ALA A 326
GLY A 323
THR A 275
 TRE  A 413 (-4.1A)
None
None
None
 1.25A 4bboC-6czsA:
undetectable		 4bboC-6czsA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6elc VARIANT SURFACE
GLYCOPROTEIN

(Trypanosoma
brucei) 		no annotation 4 ASN A 236
ALA A 257
GLY A 256
THR A 261
 None
 1.25A 4bboC-6elcA:
undetectable		 4bboC-6elcA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6enx NAD-DEPENDENT
PROTEIN DEACYLASE
SIRTUIN-5,
MITOCHONDRIAL

(Danio rerio) 		no annotation 4 ASN A 137
ALA A  55
GLY A  54
THR A 246
 None
BJW  A 303 (-3.5A)
BJW  A 303 (-3.2A)
BJW  A 303 (-3.7A)
 1.20A 4bboC-6enxA:
undetectable		 4bboC-6enxA:
15.87
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
8pch CATHEPSIN H

(Sus scrofa) 		PF00112
(Peptidase_C1) 		4 ASN A 198
ALA A 204
GLY A 201
THR A 155
 None
 1.25A 4bboC-8pchA:
undetectable		 4bboC-8pchA:
21.59