SIMILAR PATTERNS OF AMINO ACIDS FOR 4BBO_B_ACTB1114

List of similar pattern of amino acids derived from ASSAM search

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click link on the last column to view superposed patterns of amino acids in NGL viewer)
(Note that only 3-12 residue patterns can be used for ASSAM searches)
Filter list by:
Hit Macromolecule/
Organism		 Pfam Res. Interface HETATM RMSD Dali Z-score Seq. Identity (%) View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1bk6 KARYOPHERIN ALPHA

(Saccharomyces
cerevisiae) 		PF00514
(Arm)
PF16186
(Arm_3) 		3 TRP A 195
TRP A 237
THR A 238
 None
 1.40A 4bboB-1bk6A:
undetectable		 4bboB-1bk6A:
14.91
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1dlp LECTIN SCAFET
PRECURSOR

(Hyacinthoides
hispanica) 		PF01453
(B_lectin) 		3 TRP A  48
TRP A 233
THR A 234
 None
 1.38A 4bboB-1dlpA:
0.2		 4bboB-1dlpA:
20.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1dlp LECTIN SCAFET
PRECURSOR

(Hyacinthoides
hispanica) 		PF01453
(B_lectin) 		3 TRP A 108
TRP A 204
THR A 205
 None
 1.45A 4bboB-1dlpA:
0.2		 4bboB-1dlpA:
20.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1gwc GLUTATHIONE
S-TRANSFERASE TSI-1

(Aegilops
tauschii) 		PF00043
(GST_C)
PF02798
(GST_N) 		3 TRP A 171
TRP A 113
THR A 175
 None
 1.47A 4bboB-1gwcA:
0.0		 4bboB-1gwcA:
18.47
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1hn0 CHONDROITIN ABC
LYASE I

(Proteus
vulgaris) 		PF02278
(Lyase_8)
PF02884
(Lyase_8_C)
PF09092
(Lyase_N)
PF09093
(Lyase_catalyt) 		3 TRP A 390
TRP A 397
THR A 340
 None
 1.13A 4bboB-1hn0A:
1.4		 4bboB-1hn0A:
8.97
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1hn0 CHONDROITIN ABC
LYASE I

(Proteus
vulgaris) 		PF02278
(Lyase_8)
PF02884
(Lyase_8_C)
PF09092
(Lyase_N)
PF09093
(Lyase_catalyt) 		3 TRP A 983
TRP A 934
THR A 946
 None
 1.44A 4bboB-1hn0A:
1.4		 4bboB-1hn0A:
8.97
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1jj4 REGULATORY PROTEIN
E2

(Alphapapillomavirus
7) 		PF00511
(PPV_E2_C) 		3 TRP A 322
TRP A 320
THR A 334
 None
 1.39A 4bboB-1jj4A:
undetectable		 4bboB-1jj4A:
19.49
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1kcg ULBP3 PROTEIN

(Homo sapiens) 		PF00129
(MHC_I) 		3 TRP C 152
TRP C 138
THR C 159
 None
 1.36A 4bboB-1kcgC:
2.1		 4bboB-1kcgC:
18.44
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ksi COPPER AMINE OXIDASE

(Pisum sativum) 		PF01179
(Cu_amine_oxid)
PF02727
(Cu_amine_oxidN2)
PF02728
(Cu_amine_oxidN3) 		3 TRP A 596
TRP A 581
THR A 577
 None
 1.45A 4bboB-1ksiA:
0.5		 4bboB-1ksiA:
11.41
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1lxy ARGININE DEIMINASE

(Mycoplasma
arginini) 		PF02274
(Amidinotransf) 		3 TRP A 264
TRP A 273
THR A 272
 None
None
CIR  A 500 (-4.5A)
 1.36A 4bboB-1lxyA:
0.0		 4bboB-1lxyA:
12.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1m2w MANNITOL
DEHYDROGENASE

(Pseudomonas
fluorescens) 		PF01232
(Mannitol_dh)
PF08125
(Mannitol_dh_C) 		3 TRP A  58
TRP A 277
THR A  46
 None
 1.35A 4bboB-1m2wA:
undetectable		 4bboB-1m2wA:
13.48
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1mhz METHANE
MONOOXYGENASE
HYDROXYLASE

(Methylosinus
trichosporium) 		PF02332
(Phenol_Hydrox) 		3 TRP D 308
TRP D 301
THR D 283
 None
 1.45A 4bboB-1mhzD:
0.0		 4bboB-1mhzD:
13.17
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1mty METHANE
MONOOXYGENASE
HYDROXYLASE

(Methylococcus
capsulatus) 		PF02332
(Phenol_Hydrox) 		3 TRP D 308
TRP D 301
THR D 283
 None
 1.39A 4bboB-1mtyD:
undetectable		 4bboB-1mtyD:
12.96
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1o4z BETA-AGARASE B

(Zobellia
galactanivorans) 		PF00722
(Glyco_hydro_16) 		3 TRP A 109
TRP A 117
THR A 115
 None
 1.26A 4bboB-1o4zA:
undetectable		 4bboB-1o4zA:
15.41
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1qyi HYPOTHETICAL PROTEIN

(Staphylococcus
aureus) 		PF13242
(Hydrolase_like) 		3 TRP A  78
TRP A 174
THR A 175
 None
 1.36A 4bboB-1qyiA:
undetectable		 4bboB-1qyiA:
16.67
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1sqe HYPOTHETICAL PROTEIN
PG130

(Staphylococcus
aureus) 		PF03992
(ABM) 		3 TRP A  82
TRP A  73
THR A  71
 None
 1.01A 4bboB-1sqeA:
undetectable		 4bboB-1sqeA:
20.90
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1tis THYMIDYLATE SYNTHASE

(Escherichia
virus T4) 		PF00303
(Thymidylat_synt) 		3 TRP A  87
TRP A  61
THR A  67
 None
 1.49A 4bboB-1tisA:
undetectable		 4bboB-1tisA:
17.71
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ufa TT1467 PROTEIN

(Thermus
thermophilus) 		PF03065
(Glyco_hydro_57)
PF09210
(DUF1957) 		3 TRP A 404
TRP A 274
THR A 270
 None
 1.31A 4bboB-1ufaA:
undetectable		 4bboB-1ufaA:
14.39
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1wa5 IMPORTIN ALPHA
SUBUNIT

(Saccharomyces
cerevisiae) 		PF00514
(Arm)
PF01749
(IBB)
PF16186
(Arm_3) 		3 TRP B 195
TRP B 237
THR B 238
 None
 1.40A 4bboB-1wa5B:
undetectable		 4bboB-1wa5B:
13.02
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1zlr COAGULATION FACTOR
XI

(Homo sapiens) 		PF00089
(Trypsin) 		3 TRP A 137
TRP A  27
THR A 139
 None
 1.46A 4bboB-1zlrA:
undetectable		 4bboB-1zlrA:
19.57
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2ayn UBIQUITIN
CARBOXYL-TERMINAL
HYDROLASE 14

(Homo sapiens) 		PF00443
(UCH) 		3 TRP A 471
TRP A 438
THR A 424
 None
 1.00A 4bboB-2aynA:
undetectable		 4bboB-2aynA:
13.54
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2c0h MANNAN
ENDO-1,4-BETA-MANNOS
IDASE

(Mytilus edulis) 		PF00150
(Cellulase) 		3 TRP A  79
TRP A 337
THR A 340
 None
 1.21A 4bboB-2c0hA:
undetectable		 4bboB-2c0hA:
16.95
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2g3n ALPHA-GLUCOSIDASE

(Sulfolobus
solfataricus) 		PF01055
(Glyco_hydro_31)
PF13802
(Gal_mutarotas_2) 		3 TRP A 302
TRP A 301
THR A 298
 None
 1.32A 4bboB-2g3nA:
undetectable		 4bboB-2g3nA:
10.41
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2g3w HYPOTHETICAL PROTEIN
XAC2396

(Xanthomonas
citri) 		PF07152
(YaeQ) 		3 TRP A 116
TRP A 115
THR A 112
 None
 1.46A 4bboB-2g3wA:
undetectable		 4bboB-2g3wA:
23.70
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2h4t CARNITINE
O-PALMITOYLTRANSFERA
SE II, MITOCHONDRIAL

(Rattus
norvegicus) 		PF00755
(Carn_acyltransf) 		3 TRP A 299
TRP A 351
THR A 224
 None
 1.35A 4bboB-2h4tA:
undetectable		 4bboB-2h4tA:
11.74
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2iuj LIPOXYGENASE L-5

(Glycine max) 		PF00305
(Lipoxygenase)
PF01477
(PLAT) 		3 TRP A 588
TRP A 679
THR A 591
 None
 1.47A 4bboB-2iujA:
undetectable		 4bboB-2iujA:
8.79
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2iuk SEED LIPOXYGENASE

(Glycine max) 		PF00305
(Lipoxygenase)
PF01477
(PLAT) 		3 TRP A 600
TRP A 691
THR A 603
 None
 1.46A 4bboB-2iukA:
undetectable		 4bboB-2iukA:
8.64
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2k2o MYOFERLIN

(Homo sapiens) 		no annotation 3 TRP A 980
TRP A 975
THR A 968
 None
 1.28A 4bboB-2k2oA:
undetectable		 4bboB-2k2oA:
22.83
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2stt ETS1

(Homo sapiens) 		PF00178
(Ets) 		3 TRP A  51
TRP A  46
THR A  47
 None
 1.42A 4bboB-2sttA:
undetectable		 4bboB-2sttA:
14.41
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2wzs PUTATIVE
ALPHA-1,2-MANNOSIDAS
E

(Bacteroides
thetaiotaomicron) 		PF07971
(Glyco_hydro_92) 		3 TRP A 537
TRP A 541
THR A 540
 None
 1.50A 4bboB-2wzsA:
2.2		 4bboB-2wzsA:
11.19
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2x8r GLYCOSYL HYDROLASE

(Aspergillus
fumigatus) 		PF01183
(Glyco_hydro_25) 		3 TRP A 151
TRP A 150
THR A 147
 None
CL  A1219 (-4.6A)
None
 1.48A 4bboB-2x8rA:
undetectable		 4bboB-2x8rA:
23.50
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2y32 BLR5658 PROTEIN

(Bradyrhizobium
japonicum) 		PF01382
(Avidin) 		3 TRP A   5
TRP A   7
THR A  83
 None
 0.34A 4bboB-2y32A:
19.6		 4bboB-2y32A:
100.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2zec TRYPTASE BETA 2

(Homo sapiens) 		PF00089
(Trypsin) 		3 TRP A 141
TRP A  27
THR A 143
 None
 1.49A 4bboB-2zecA:
undetectable		 4bboB-2zecA:
17.52
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3b9i GITR LIGAND

(Mus musculus) 		no annotation 3 TRP A 161
TRP A  63
THR A  76
 None
 1.48A 4bboB-3b9iA:
undetectable		 4bboB-3b9iA:
21.32
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3eaf ABC TRANSPORTER,
SUBSTRATE BINDING
PROTEIN

(Aeropyrum
pernix) 		PF13458
(Peripla_BP_6) 		3 TRP A 274
TRP A 124
THR A  58
 GOL  A 500 (-3.7A)
GOL  A 500 (-3.7A)
GOL  A 500 ( 4.3A)
 1.35A 4bboB-3eafA:
undetectable		 4bboB-3eafA:
16.58
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3h0o BETA-GLUCANASE

(Fibrobacter
succinogenes) 		PF00722
(Glyco_hydro_16) 		3 TRP A 198
TRP A 186
THR A 187
 None
 1.35A 4bboB-3h0oA:
undetectable		 4bboB-3h0oA:
22.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3hpa AMIDOHYDROLASE

(unidentified) 		PF01979
(Amidohydro_1) 		3 TRP A 115
TRP A 123
THR A 101
 None
 1.49A 4bboB-3hpaA:
undetectable		 4bboB-3hpaA:
12.91
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3hyq ISOPENTENYL-DIPHOSPH
ATE DELTA-ISOMERASE

(Salmonella
enterica) 		PF00293
(NUDIX) 		3 TRP A  58
TRP A 161
THR A  63
 None
 1.28A 4bboB-3hyqA:
undetectable		 4bboB-3hyqA:
21.98
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ica PHENYLALANYL-TRNA
SYNTHETASE BETA
CHAIN

(Porphyromonas
gingivalis) 		no annotation 3 TRP A 206
TRP A  86
THR A   8
 None
GOL  A 215 (-4.0A)
GOL  A 215 (-4.6A)
 1.34A 4bboB-3icaA:
undetectable		 4bboB-3icaA:
20.48
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3jbf NANOBODY VHH PVSP19B

(Camelus
dromedarius) 		PF07686
(V-set) 		3 TRP 7  97
TRP 7  33
THR 7  50
 None
 1.20A 4bboB-3jbf7:
undetectable		 4bboB-3jbf7:
22.63
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3khk TYPE I
RESTRICTION-MODIFICA
TION SYSTEM
METHYLATION SUBUNIT

(Methanosarcina
mazei) 		PF02384
(N6_Mtase)
PF12161
(HsdM_N) 		3 TRP A 354
TRP A 344
THR A 369
 None
 1.39A 4bboB-3khkA:
undetectable		 4bboB-3khkA:
12.62
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ldr FRUCTOSYLTRANSFERASE

(Aspergillus
japonicus) 		PF00251
(Glyco_hydro_32N)
PF08244
(Glyco_hydro_32C) 		3 TRP A  45
TRP A 618
THR A  25
 None
 1.42A 4bboB-3ldrA:
undetectable		 4bboB-3ldrA:
12.33
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3n0g ISOPRENE SYNTHASE

(Populus tremula
x Populus alba) 		PF01397
(Terpene_synth)
PF03936
(Terpene_synth_C) 		3 TRP A 295
TRP A 294
THR A 291
 None
 1.45A 4bboB-3n0gA:
undetectable		 4bboB-3n0gA:
12.15
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3o12 UNCHARACTERIZED
PROTEIN YJL217W

(Saccharomyces
cerevisiae) 		PF07081
(DUF1349) 		3 TRP A 115
TRP A  39
THR A  42
 EDO  A 206 (-3.7A)
EDO  A 207 ( 4.0A)
None
 1.26A 4bboB-3o12A:
undetectable		 4bboB-3o12A:
26.63
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3qr8 BASEPLATE ASSEMBLY
PROTEIN V

(Escherichia
virus P2) 		PF04717
(Phage_base_V) 		3 TRP A  58
TRP A  47
THR A  49
 None
 1.46A 4bboB-3qr8A:
undetectable		 4bboB-3qr8A:
18.10
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3s99 BASIC MEMBRANE
LIPOPROTEIN

(Brucella
abortus) 		PF02608
(Bmp) 		3 TRP A 249
TRP A  36
THR A  87
 None
ADE  A 400 (-3.4A)
None
 1.10A 4bboB-3s99A:
undetectable		 4bboB-3s99A:
16.76
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3t6d PHOTOSYNTHETIC
REACTION CENTER
M-SUBUNIT

(Blastochloris
viridis) 		PF00124
(Photo_RC) 		3 TRP M 199
TRP M 292
THR M 285
 None
 1.47A 4bboB-3t6dM:
undetectable		 4bboB-3t6dM:
17.24
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ui7 CAMP AND
CAMP-INHIBITED CGMP
3',5'-CYCLIC
PHOSPHODIESTERASE
10A

(Homo sapiens) 		PF00233
(PDEase_I) 		3 TRP A 762
TRP A 682
THR A 685
 None
 1.26A 4bboB-3ui7A:
undetectable		 4bboB-3ui7A:
15.12
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3uxf FIMBRIAL SUBUNIT
TYPE 1

(Actinomyces
oris) 		no annotation 3 TRP A 273
TRP A 333
THR A 275
 None
 1.44A 4bboB-3uxfA:
undetectable		 4bboB-3uxfA:
11.74
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3wz1 AGARASE

(Microbulbifer
thermotolerans) 		PF00722
(Glyco_hydro_16) 		3 TRP A  72
TRP A  80
THR A  78
 None
 1.26A 4bboB-3wz1A:
undetectable		 4bboB-3wz1A:
18.79
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3x0u UNCHARACTERIZED
PROTEIN

(Vibrio
parahaemolyticus) 		PF03945
(Endotoxin_N) 		3 TRP A  63
TRP A  76
THR A 164
 None
 1.50A 4bboB-3x0uA:
undetectable		 4bboB-3x0uA:
14.49
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4atf BETA-AGARASE B

(Zobellia
galactanivorans) 		PF00722
(Glyco_hydro_16) 		3 TRP A 109
TRP A 117
THR A 115
 GAL  A1355 (-3.6A)
None
None
 1.31A 4bboB-4atfA:
undetectable		 4bboB-4atfA:
15.91
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4bbo BLR5658 PROTEIN

(Bradyrhizobium
japonicum) 		PF01382
(Avidin) 		3 TRP A   5
TRP A   7
THR A  83
 GOL  A1114 (-3.8A)
None
GOL  A1114 ( 4.6A)
 0.11A 4bboB-4bboA:
23.6		 4bboB-4bboA:
100.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4h59 IRON-COMPOUND ABC
TRANSPORTER, IRON
COMPOUND-BINDING
PROTEIN

(Streptococcus
pneumoniae) 		PF01497
(Peripla_BP_2) 		3 TRP A  63
TRP A  95
THR A  96
 B3P  A 401 ( 3.9A)
None
None
 1.17A 4bboB-4h59A:
undetectable		 4bboB-4h59A:
15.58
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4hmw PYRIDOXAMINE
5'-PHOSPHATE OXIDASE

(Burkholderia
lata) 		PF01243
(Putative_PNPOx)
PF10590
(PNP_phzG_C) 		3 TRP A  34
TRP A 101
THR A 104
 None
 1.34A 4bboB-4hmwA:
1.6		 4bboB-4hmwA:
19.07
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4hsu LYSINE-SPECIFIC
HISTONE DEMETHYLASE
1B

(Homo sapiens) 		PF01593
(Amino_oxidase)
PF04433
(SWIRM)
PF07496
(zf-CW) 		3 TRP A 422
TRP A 757
THR A 755
 None
FAD  A 901 (-3.6A)
None
 1.42A 4bboB-4hsuA:
undetectable		 4bboB-4hsuA:
9.92
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ijr D-ARABINOSE
DEHYDROGENASE
[NAD(P)+] HEAVY
CHAIN

(Saccharomyces
cerevisiae) 		PF00248
(Aldo_ket_red) 		3 TRP A 132
TRP A 102
THR A 151
 NDP  A 401 ( 4.1A)
None
None
 1.42A 4bboB-4ijrA:
undetectable		 4bboB-4ijrA:
16.17
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4isb LONG CHAIN FATTY
ACID COA LIGASE
FADD10

(Mycobacterium
tuberculosis) 		PF00501
(AMP-binding)
PF13193
(AMP-binding_C) 		3 TRP A 211
TRP A 231
THR A 263
 None
 1.09A 4bboB-4isbA:
undetectable		 4bboB-4isbA:
14.47
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4j72 PHOSPHO-N-ACETYLMURA
MOYL-PENTAPEPTIDE-TR
ANSFERASE

(Aquifex
aeolicus) 		PF00953
(Glycos_transf_4)
PF10555
(MraY_sig1) 		3 TRP A  95
TRP A 101
THR A 100
 None
 1.21A 4bboB-4j72A:
undetectable		 4bboB-4j72A:
17.39
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4je5 AROMATIC/AMINOADIPAT
E AMINOTRANSFERASE 1

(Saccharomyces
cerevisiae) 		PF00155
(Aminotran_1_2) 		3 TRP A 360
TRP A 352
THR A 348
 None
 1.46A 4bboB-4je5A:
undetectable		 4bboB-4je5A:
12.75
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4jo0 CMLA

(Streptomyces
venezuelae) 		PF12706
(Lactamase_B_2) 		3 TRP A  17
TRP A  78
THR A  82
 None
 1.35A 4bboB-4jo0A:
undetectable		 4bboB-4jo0A:
12.17
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4jso OLIGOPEPTIDE ABC
TRANSPORTER,
PERIPLASMIC
OLIGOPEPTIDE-BINDING
PROTEIN

(Thermotoga
maritima) 		PF00496
(SBP_bac_5) 		3 TRP A 540
TRP A 529
THR A 542
 None
 1.35A 4bboB-4jsoA:
undetectable		 4bboB-4jsoA:
12.23
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4jzn ANTI-HCV E2 FAB
HC84-1 HEAVY CHAIN
ANTI-HCV E2 FAB
HC84-1 LIGHT CHAIN

(Homo sapiens;
Homo sapiens) 		PF07654
(C1-set)
PF07686
(V-set)
PF07654
(C1-set)
PF07686
(V-set) 		3 TRP B  90
TRP A  47
THR A  35
 None
 1.42A 4bboB-4jznB:
undetectable		 4bboB-4jznB:
22.33
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4k5y CORTICOTROPIN-RELEAS
ING FACTOR RECEPTOR
1, T4-LYSOZYME
CHIMERIC CONSTRUCT

(Homo sapiens;
Escherichia
virus T4) 		PF00002
(7tm_2)
PF00959
(Phage_lysozyme) 		3 TRP A 259
TRP A 246
THR A 268
 None
 1.27A 4bboB-4k5yA:
undetectable		 4bboB-4k5yA:
16.82
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4mag SIALIC ACID BINDING
PROTEIN

(Vibrio cholerae) 		PF03480
(DctP) 		3 TRP A  73
TRP A 114
THR A  56
 None
 1.16A 4bboB-4magA:
undetectable		 4bboB-4magA:
18.09
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4n4k HYDROXYLAMINE
OXIDOREDUCTASE

(Candidatus
Kuenenia
stuttgartiensis) 		PF13447
(Multi-haem_cyto) 		3 TRP A  94
TRP A 101
THR A 102
 None
 1.30A 4bboB-4n4kA:
undetectable		 4bboB-4n4kA:
12.96
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4q7q LIPOLYTIC PROTEIN
G-D-S-L FAMILY

(Chitinophaga
pinensis) 		PF13472
(Lipase_GDSL_2) 		3 TRP A 100
TRP A  99
THR A  96
 None
 1.47A 4bboB-4q7qA:
undetectable		 4bboB-4q7qA:
18.89
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4qi8 LYTIC POLYSACCHARIDE
MONOOXYGENASE

(Neurospora
crassa) 		PF03443
(Glyco_hydro_61) 		3 TRP A  99
TRP A  92
THR A  93
 None
 1.16A 4bboB-4qi8A:
undetectable		 4bboB-4qi8A:
22.56
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4qmi CYTOSKELETON-ASSOCIA
TED PROTEIN 5

(Homo sapiens) 		PF12348
(CLASP_N) 		3 TRP A 968
TRP A 977
THR A 972
 None
 1.13A 4bboB-4qmiA:
undetectable		 4bboB-4qmiA:
19.07
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4r0i SUPPRESSOR OF
TUMORIGENICITY 14
PROTEIN

(Homo sapiens) 		PF00089
(Trypsin) 		3 TRP A 137
TRP A  27
THR A 139
 None
 1.43A 4bboB-4r0iA:
undetectable		 4bboB-4r0iA:
21.24
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4wd1 ACETOACETATE-COA
LIGASE

(Streptomyces
lividans) 		PF00501
(AMP-binding)
PF13193
(AMP-binding_C)
PF16177
(ACAS_N) 		3 TRP A 173
TRP A 320
THR A 315
 None
 1.18A 4bboB-4wd1A:
undetectable		 4bboB-4wd1A:
10.40
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4zaa FDC1

(Aspergillus
niger) 		PF01977
(UbiD) 		3 TRP A 472
TRP A 416
THR A 420
 None
 1.33A 4bboB-4zaaA:
undetectable		 4bboB-4zaaA:
13.67
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4zet C-TYPE LECTIN DOMAIN
FAMILY 4 MEMBER C

(Homo sapiens) 		PF00059
(Lectin_C) 		3 TRP A 153
TRP A 168
THR A 166
 None
 1.48A 4bboB-4zetA:
undetectable		 4bboB-4zetA:
21.33
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5bn7 MALTODEXTRIN
GLUCOSIDASE

(Escherichia
coli) 		PF00128
(Alpha-amylase) 		3 TRP A 469
TRP A 473
THR A 472
 None
 1.20A 4bboB-5bn7A:
undetectable		 4bboB-5bn7A:
10.07
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5eod COAGULATION FACTOR
XI

(Homo sapiens) 		PF00024
(PAN_1)
PF00089
(Trypsin) 		3 TRP A 497
TRP A 381
THR A 499
 None
 1.36A 4bboB-5eodA:
undetectable		 4bboB-5eodA:
11.57
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5esa ANTI-HCV E2
GLYCOPROTEIN FAB
HEAVY CHAIN
ANTI-HCV E2
GLYCOPROTEIN FAB
LIGHT CHAIN

(Homo sapiens;
Homo sapiens) 		PF07654
(C1-set)
PF07686
(V-set)
PF07654
(C1-set)
PF07686
(V-set) 		3 TRP B  90
TRP A  47
THR A  35
 None
 1.46A 4bboB-5esaB:
undetectable		 4bboB-5esaB:
19.27
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5f8z PLASMA KALLIKREIN
LIGHT CHAIN

(Homo sapiens) 		PF00089
(Trypsin) 		3 TRP A 137
TRP A  27
THR A 139
 SO4  A 304 (-4.0A)
SO4  A 304 ( 4.7A)
None
 1.41A 4bboB-5f8zA:
undetectable		 4bboB-5f8zA:
19.15
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5gjq UBIQUITIN
CARBOXYL-TERMINAL
HYDROLASE 14

(Homo sapiens) 		PF00227
(Proteasome)
PF10584
(Proteasome_A_N) 		3 TRP x 471
TRP x 438
THR x 424
 None
 0.99A 4bboB-5gjqx:
undetectable		 4bboB-5gjqx:
13.15
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5gp4 GLUTAMATE
DECARBOXYLASE

(Lactobacillus
brevis) 		no annotation 3 TRP C 110
TRP C 263
THR C 254
 None
 1.43A 4bboB-5gp4C:
undetectable		 4bboB-5gp4C:
12.39
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5gvt PLASMA KALLIKREIN

(Mus musculus) 		no annotation 3 TRP A 137
TRP A  27
THR A 139
 None
 1.42A 4bboB-5gvtA:
undetectable		 4bboB-5gvtA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5i61 POTENTIAL
RNA-DEPENDENT RNA
POLYMERASE

(Human
picobirnavirus) 		no annotation 3 TRP B  62
TRP B 402
THR B  64
 None
 1.09A 4bboB-5i61B:
undetectable		 4bboB-5i61B:
12.83
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ldr BETA-D-GALACTOSIDASE

(Paracoccus sp.
32d) 		PF00703
(Glyco_hydro_2)
PF02836
(Glyco_hydro_2_C)
PF02837
(Glyco_hydro_2_N) 		3 TRP B 146
TRP B 308
THR B 307
 None
 1.26A 4bboB-5ldrB:
undetectable		 4bboB-5ldrB:
10.88
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ly6 PNEUMOLYSIN

(Streptococcus
pneumoniae) 		PF01289
(Thiol_cytolysin)
PF17440
(Thiol_cytolys_C) 		3 TRP B 397
TRP B 379
THR B 378
 None
 1.31A 4bboB-5ly6B:
undetectable		 4bboB-5ly6B:
14.80
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5m8t 5,6-DIHYDROXYINDOLE-
2-CARBOXYLIC ACID
OXIDASE

(Homo sapiens) 		PF00264
(Tyrosinase) 		3 TRP A  90
TRP A 444
THR A  98
 None
 1.49A 4bboB-5m8tA:
undetectable		 4bboB-5m8tA:
15.86
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5mmh HTH-TYPE
TRANSCRIPTIONAL
ACTIVATOR AMPR

(Pseudomonas
aeruginosa) 		PF03466
(LysR_substrate) 		3 TRP A 265
TRP A 152
THR A 155
 None
 1.47A 4bboB-5mmhA:
undetectable		 4bboB-5mmhA:
16.14
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ngj TAIL TUBE PROTEIN

(Escherichia
virus T5) 		no annotation 3 TRP A  95
TRP A 169
THR A  74
 None
 1.30A 4bboB-5ngjA:
undetectable		 4bboB-5ngjA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5t9x GLYCOSIDE HYDROLASE

(Bacteroides
uniformis) 		no annotation 3 TRP A  99
TRP A 107
THR A 105
 None
 1.22A 4bboB-5t9xA:
undetectable		 4bboB-5t9xA:
15.45
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5tr0 SEED LINOLEATE
13S-LIPOXYGENASE-1

(Glycine max) 		no annotation 3 TRP A 574
TRP A 665
THR A 577
 None
 1.50A 4bboB-5tr0A:
0.9		 4bboB-5tr0A:
9.63
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5vqi IMPORTIN SUBUNIT
ALPHA

(Neurospora
crassa) 		no annotation 3 TRP B 188
TRP B 231
THR B 232
 None
 1.40A 4bboB-5vqiB:
undetectable		 4bboB-5vqiB:
14.01
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5x3j GLYCOSIDE HYDROLASE
FAMILY 31

(Kribbella
flavida) 		no annotation 3 TRP A 432
TRP A 431
THR A 428
 None
 1.33A 4bboB-5x3jA:
undetectable		 4bboB-5x3jA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6bv2 AMINOPEPTIDASE N

(Sus scrofa) 		no annotation 3 TRP A 513
TRP A 403
THR A 451
 None
 1.35A 4bboB-6bv2A:
undetectable		 4bboB-6bv2A:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6c08 SODIUM-COUPLED
NEUTRAL AMINO ACID
TRANSPORTER 9

(Danio rerio) 		no annotation 3 TRP C 272
TRP C 273
THR C 276
 None
 1.47A 4bboB-6c08C:
undetectable		 4bboB-6c08C:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6d6y APRA
METHYLTRANSFERASE 2

(Moorea
bouillonii) 		no annotation 3 TRP A 626
TRP A 584
THR A 579
 None
 1.11A 4bboB-6d6yA:
undetectable		 4bboB-6d6yA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6emk TARGET OF RAPAMYCIN
COMPLEX SUBUNIT LST8

(Saccharomyces
cerevisiae) 		no annotation 3 TRP B 252
TRP B 254
THR B 211
 None
 1.23A 4bboB-6emkB:
undetectable		 4bboB-6emkB:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6fbt LYTIC MUREIN
TRANSGLYCOSYLASE

(Pseudomonas
aeruginosa) 		no annotation 3 TRP A 586
TRP A 598
THR A 601
 None
 1.39A 4bboB-6fbtA:
undetectable		 4bboB-6fbtA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6gup -

(-) 		no annotation 3 TRP A 301
TRP A 314
THR A 305
 None
 1.33A 4bboB-6gupA:
undetectable		 4bboB-6gupA:
undetectable