SIMILAR PATTERNS OF AMINO ACIDS FOR 4B7Q_B_ZMRB601_2

List of similar pattern of amino acids derived from ASSAM search

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click link on the last column to view superposed patterns of amino acids in NGL viewer)
(Note that only 3-12 residue patterns can be used for ASSAM searches)
Filter list by:
Hit Macromolecule/
Organism		 Pfam Res. Interface HETATM RMSD Dali Z-score Seq. Identity (%) View Dock
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1nmb N9 NEURAMINIDASE

(Influenza A
virus) 		PF00064
(Neur) 		4 LEU N 134
ARG N 152
ARG N 156
TRP N 178
 None
 0.37A 4b7qB-1nmbN:
63.0		 4b7qB-1nmbN:
45.62
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1v0z NEURAMINIDASE

(Influenza A
virus) 		PF00064
(Neur) 		4 LEU A 140
ARG A 158
ARG A 162
TRP A 185
 None
 0.19A 4b7qB-1v0zA:
64.0		 4b7qB-1v0zA:
38.98
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1vcj NEURAMINIDASE

(Influenza B
virus) 		PF00064
(Neur) 		4 LEU A 132
ARG A 150
ARG A 154
TRP A 177
 None
IBA  A   1 (-3.9A)
IBA  A   1 (-4.1A)
None
 0.41A 4b7qB-1vcjA:
52.4		 4b7qB-1vcjA:
32.29
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1xog NEURAMINIDASE

(Influenza A
virus) 		PF00064
(Neur) 		4 LEU A 135
ARG A 153
ARG A 157
TRP A 180
 None
ABW  A1000 (-4.1A)
ABW  A1000 (-4.2A)
None
 0.54A 4b7qB-1xogA:
63.6		 4b7qB-1xogA:
41.40
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2htv NEURAMINIDASE

(Influenza A
virus) 		PF00064
(Neur) 		4 LEU A 134
ARG A 152
ARG A 156
TRP A 178
 None
 0.51A 4b7qB-2htvA:
69.6		 4b7qB-2htvA:
66.35
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3ckz NEURAMINIDASE

(Influenza A
virus) 		PF00064
(Neur) 		4 LEU A 134
ARG A 152
ARG A 156
TRP A 178
 None
ZMR  A 469 (-3.9A)
ZMR  A 469 (-3.4A)
None
 0.73A 4b7qB-3ckzA:
74.1		 4b7qB-3ckzA:
91.17
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3ti8 NEURAMINIDASE

(Influenza A
virus) 		PF00064
(Neur) 		4 LEU A 134
ARG A 152
ARG A 156
TRP A 178
 None
LNV  A 901 (-4.0A)
LNV  A 901 (-4.0A)
None
 0.16A 4b7qB-3ti8A:
69.9		 4b7qB-3ti8A:
48.63
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3tia NEURAMINIDASE

(Influenza A
virus) 		PF00064
(Neur) 		4 LEU A 134
ARG A 152
ARG A 156
TRP A 178
 None
LNV  A 801 (-3.9A)
LNV  A 801 (-4.0A)
None
 0.15A 4b7qB-3tiaA:
63.8		 4b7qB-3tiaA:
45.55
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4b7j NEURAMINIDASE

(Influenza A
virus) 		PF00064
(Neur) 		4 LEU A 134
ARG A 152
ARG A 156
TRP A 179
 None
G39  A1470 (-3.9A)
None
None
 0.17A 4b7qB-4b7jA:
74.9		 4b7qB-4b7jA:
99.15
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4cpn NEURAMINIDASE

(Influenza B
virus) 		PF00064
(Neur) 		4 LEU A 131
ARG A 149
ARG A 153
TRP A 176
 None
ZMR  A 700 (-4.0A)
ZMR  A 700 (-4.2A)
None
 0.19A 4b7qB-4cpnA:
53.2		 4b7qB-4cpnA:
34.36
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4h53 NEURAMINIDASE

(Influenza A
virus) 		PF00064
(Neur) 		4 LEU A 134
ARG A 152
ARG A 156
TRP A 178
 None
SLB  A 512 (-3.8A)
None
None
 0.14A 4b7qB-4h53A:
63.9		 4b7qB-4h53A:
41.63
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4hzz NEURAMINIDASE

(Influenza A
virus) 		PF00064
(Neur) 		4 LEU A 134
ARG A 152
ARG A 156
TRP A 178
 None
G39  A 509 (-3.9A)
None
None
 0.20A 4b7qB-4hzzA:
63.2		 4b7qB-4hzzA:
40.42
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4mju NEURAMINIDASE

(Influenza A
virus) 		PF00064
(Neur) 		4 LEU A 134
ARG A 152
ARG A 156
TRP A 178
 None
27S  A 501 (-4.2A)
None
None
 0.67A 4b7qB-4mjuA:
67.6		 4b7qB-4mjuA:
53.96
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4qn3 NEURAMINIDASE

(Influenza A
virus) 		PF00064
(Neur) 		4 LEU A  52
ARG A  70
ARG A  74
TRP A  97
 None
 0.27A 4b7qB-4qn3A:
63.9		 4b7qB-4qn3A:
38.82
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6br6 NEURAMINIDASE

(Influenza A
virus) 		no annotation 4 LEU A 134
ARG A 152
ARG A 156
TRP A 178
 None
E3M  A 511 (-3.8A)
None
None
 0.15A 4b7qB-6br6A:
64.1		 4b7qB-6br6A:
11.31