SIMILAR PATTERNS OF AMINO ACIDS FOR 4B7Q_A_ZMRA601_2

List of similar pattern of amino acids derived from ASSAM search

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click link on the last column to view superposed patterns of amino acids in NGL viewer)
(Note that only 3-12 residue patterns can be used for ASSAM searches)
Filter list by:
Hit Macromolecule/
Organism		 Pfam Res. Interface HETATM RMSD Dali Z-score Seq. Identity (%) View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ak2 ADENYLATE KINASE
ISOENZYME-2

(Bos taurus) 		PF00406
(ADK)
PF05191
(ADK_lid) 		3 ARG A 143
ARG A 139
ILE A 145
 None
 0.90A 4b7qA-1ak2A:
undetectable		 4b7qA-1ak2A:
18.30
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1b3q PROTEIN (CHEMOTAXIS
PROTEIN CHEA)

(Thermotoga
maritima) 		PF01584
(CheW)
PF02518
(HATPase_c)
PF02895
(H-kinase_dim) 		3 ARG A 385
ARG A 437
ILE A 433
 None
 0.87A 4b7qA-1b3qA:
undetectable		 4b7qA-1b3qA:
20.41
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1b9b PROTEIN
(TRIOSEPHOSPHATE
ISOMERASE)

(Thermotoga
maritima) 		PF00121
(TIM) 		3 ARG A 208
ARG A   3
ILE A   6
 None
 0.92A 4b7qA-1b9bA:
undetectable		 4b7qA-1b9bA:
21.57
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1fzt PHOSPHOGLYCERATE
MUTASE

(Schizosaccharomyces
pombe) 		PF00300
(His_Phos_1) 		3 ARG A 185
ARG A 121
ILE A 171
 None
 0.84A 4b7qA-1fztA:
undetectable		 4b7qA-1fztA:
17.70
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1gq2 MALIC ENZYME

(Columba livia) 		PF00390
(malic)
PF03949
(Malic_M) 		3 ARG A 413
ARG A 440
ILE A 297
 None
 0.92A 4b7qA-1gq2A:
undetectable		 4b7qA-1gq2A:
23.26
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1jx2 MYOSIN-2 HEAVY
CHAIN,DYNAMIN-A

(Dictyostelium
discoideum) 		PF00063
(Myosin_head)
PF02736
(Myosin_N) 		3 ARG A 157
ARG A 158
ILE A  15
 None
 0.86A 4b7qA-1jx2A:
undetectable		 4b7qA-1jx2A:
17.25
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1la2 MYO-INOSITOL-1-PHOSP
HATE SYNTHASE

(Saccharomyces
cerevisiae) 		PF01658
(Inos-1-P_synth)
PF07994
(NAD_binding_5) 		3 ARG A 222
ARG A 225
ILE A 203
 None
 0.88A 4b7qA-1la2A:
undetectable		 4b7qA-1la2A:
22.33
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1nmb N9 NEURAMINIDASE

(Influenza A
virus) 		PF00064
(Neur) 		3 ARG N 152
ARG N 156
ILE N 222
 None
 0.42A 4b7qA-1nmbN:
63.0		 4b7qA-1nmbN:
45.62
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1oww FIBRONECTIN FIRST
TYPE III MODULE

(Homo sapiens) 		PF00041
(fn3) 		3 ARG A  36
ARG A  38
ILE A  74
 None
 0.84A 4b7qA-1owwA:
undetectable		 4b7qA-1owwA:
11.46
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1r44 D-ALANYL-D-ALANINE
DIPEPTIDASE

(Enterococcus
faecium) 		PF01427
(Peptidase_M15) 		3 ARG A 163
ARG A 167
ILE A 155
 None
 0.70A 4b7qA-1r44A:
undetectable		 4b7qA-1r44A:
18.90
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ted PKS18

(Mycobacterium
tuberculosis) 		PF00195
(Chal_sti_synt_N)
PF02797
(Chal_sti_synt_C) 		3 ARG A 392
ARG A 393
ILE A 390
 ARG  A 392 ( 0.6A)
ARG  A 393 ( 0.6A)
ILE  A 390 ( 0.7A)
 0.93A 4b7qA-1tedA:
undetectable		 4b7qA-1tedA:
21.80
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1tq4 INTERFERON-INDUCIBLE
GTPASE

(Mus musculus) 		PF05049
(IIGP) 		3 ARG A 329
ARG A 332
ILE A  92
 None
 0.89A 4b7qA-1tq4A:
undetectable		 4b7qA-1tq4A:
19.92
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1v0z NEURAMINIDASE

(Influenza A
virus) 		PF00064
(Neur) 		3 ARG A 158
ARG A 162
ILE A 229
 None
 0.29A 4b7qA-1v0zA:
63.9		 4b7qA-1v0zA:
38.98
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1v72 ALDOLASE

(Pseudomonas
putida) 		PF01212
(Beta_elim_lyase) 		3 ARG A 127
ARG A 131
ILE A 123
 None
 0.80A 4b7qA-1v72A:
undetectable		 4b7qA-1v72A:
20.25
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1vcj NEURAMINIDASE

(Influenza B
virus) 		PF00064
(Neur) 		3 ARG A 150
ARG A 154
ILE A 221
 IBA  A   1 (-3.9A)
IBA  A   1 (-4.1A)
IBA  A   1 ( 4.3A)
 0.37A 4b7qA-1vcjA:
52.5		 4b7qA-1vcjA:
32.29
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1vrq SARCOSINE OXIDASE
ALPHA SUBUNIT

(Corynebacterium
sp. U-96) 		PF01571
(GCV_T)
PF08669
(GCV_T_C)
PF12831
(FAD_oxidored)
PF13510
(Fer2_4) 		3 ARG A 167
ARG A 277
ILE A 183
 None
 0.69A 4b7qA-1vrqA:
undetectable		 4b7qA-1vrqA:
17.82
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1xog NEURAMINIDASE

(Influenza A
virus) 		PF00064
(Neur) 		3 ARG A 153
ARG A 157
ILE A 224
 ABW  A1000 (-4.1A)
ABW  A1000 (-4.2A)
ABW  A1000 ( 4.7A)
 0.46A 4b7qA-1xogA:
63.5		 4b7qA-1xogA:
41.40
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1xx6 THYMIDINE KINASE

(Clostridium
acetobutylicum) 		PF00265
(TK) 		3 ARG A 110
ARG A   3
ILE A 112
 None
 0.93A 4b7qA-1xx6A:
undetectable		 4b7qA-1xx6A:
16.52
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2anc GUANYLATE KINASE

(Escherichia
coli) 		PF00625
(Guanylate_kin) 		3 ARG A 187
ARG A 196
ILE A 183
 None
 0.95A 4b7qA-2ancA:
undetectable		 4b7qA-2ancA:
15.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2au3 DNA PRIMASE

(Aquifex
aeolicus) 		PF01807
(zf-CHC2)
PF08275
(Toprim_N)
PF13155
(Toprim_2) 		3 ARG A 369
ARG A 366
ILE A 398
 None
 0.94A 4b7qA-2au3A:
undetectable		 4b7qA-2au3A:
21.53
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2e7u GLUTAMATE-1-SEMIALDE
HYDE 2,1-AMINOMUTASE

(Thermus
thermophilus) 		PF00202
(Aminotran_3) 		3 ARG A 129
ARG A 126
ILE A 137
 None
 0.85A 4b7qA-2e7uA:
undetectable		 4b7qA-2e7uA:
20.04
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2htv NEURAMINIDASE

(Influenza A
virus) 		PF00064
(Neur) 		3 ARG A 152
ARG A 156
ILE A 222
 None
 0.32A 4b7qA-2htvA:
69.5		 4b7qA-2htvA:
66.35
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2ktr SEQUESTOSOME-1

(Rattus
norvegicus) 		PF00564
(PB1) 		3 ARG A  94
ARG A  66
ILE A  92
 None
 0.94A 4b7qA-2ktrA:
undetectable		 4b7qA-2ktrA:
13.16
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2m5w LUPUS LA PROTEIN

(Dictyostelium
discoideum) 		PF05383
(La) 		3 ARG A  70
ARG A  82
ILE A  90
 None
 0.88A 4b7qA-2m5wA:
undetectable		 4b7qA-2m5wA:
11.11
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2owo DNA LIGASE

(Escherichia
coli) 		PF01653
(DNA_ligase_aden)
PF03119
(DNA_ligase_ZBD)
PF03120
(DNA_ligase_OB)
PF12826
(HHH_2)
PF14520
(HHH_5) 		3 ARG A  40
ARG A  43
ILE A  73
 None
 0.88A 4b7qA-2owoA:
undetectable		 4b7qA-2owoA:
19.35
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2p9j HYPOTHETICAL PROTEIN
AQ2171

(Aquifex
aeolicus) 		PF08282
(Hydrolase_3) 		3 ARG A 150
ARG A 142
ILE A  43
 None
 0.91A 4b7qA-2p9jA:
undetectable		 4b7qA-2p9jA:
17.79
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2pjq UNCHARACTERIZED
PROTEIN LP_2664

(Lactobacillus
plantarum) 		PF01966
(HD) 		3 ARG A  32
ARG A  35
ILE A 131
 None
 0.84A 4b7qA-2pjqA:
undetectable		 4b7qA-2pjqA:
18.62
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2vfv XYLITOL OXIDASE

(Streptomyces
coelicolor) 		PF01565
(FAD_binding_4)
PF04030
(ALO) 		3 ARG A 359
ARG A 358
ILE A 308
 None
 0.74A 4b7qA-2vfvA:
undetectable		 4b7qA-2vfvA:
18.80
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2vxr BOTULINUM NEUROTOXIN
TYPE G

(Clostridium
botulinum) 		PF07951
(Toxin_R_bind_C)
PF07953
(Toxin_R_bind_N) 		3 ARG A1272
ARG A1271
ILE A1277
 None
 0.93A 4b7qA-2vxrA:
undetectable		 4b7qA-2vxrA:
22.08
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2wrz L-ARABINOSE-BINDING
PERIPLASMIC PROTEIN

(Escherichia
coli) 		PF00532
(Peripla_BP_1) 		3 ARG A 151
ARG A 150
ILE A 231
 None
 0.93A 4b7qA-2wrzA:
undetectable		 4b7qA-2wrzA:
21.05
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2wuq BETA-LACTAMASE
REGULATORY PROTEIN
BLAB

(Streptomyces
cacaoi) 		PF13354
(Beta-lactamase2) 		3 ARG A  12
ARG A   9
ILE A  37
 None
GOL  A1317 (-3.9A)
None
 0.94A 4b7qA-2wuqA:
undetectable		 4b7qA-2wuqA:
18.30
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2wzm ALDO-KETO REDUCTASE

(Mycolicibacterium
smegmatis) 		PF00248
(Aldo_ket_red) 		3 ARG A 226
ARG A 218
ILE A 229
 None
 0.92A 4b7qA-2wzmA:
undetectable		 4b7qA-2wzmA:
20.70
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2y8c DEOXYURIDINE
5'-TRIPHOSPHATE
NUCLEOTIDOHYDROLASE

(Plasmodium
falciparum) 		PF00692
(dUTPase) 		3 ARG A 113
ARG A 160
ILE A  54
 None
DUQ  A 400 (-3.8A)
None
 0.70A 4b7qA-2y8cA:
undetectable		 4b7qA-2y8cA:
16.96
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2zr2 SERYL-TRNA
SYNTHETASE

(Pyrococcus
horikoshii) 		PF00587
(tRNA-synt_2b)
PF02403
(Seryl_tRNA_N) 		3 ARG A 390
ARG A 392
ILE A 265
 None
 0.90A 4b7qA-2zr2A:
undetectable		 4b7qA-2zr2A:
20.32
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3a2q 6-AMINOHEXANOATE-CYC
LIC-DIMER HYDROLASE

(Arthrobacter
sp. KI72) 		PF01425
(Amidase) 		3 ARG A  54
ARG A  55
ILE A  32
 None
 0.91A 4b7qA-3a2qA:
undetectable		 4b7qA-3a2qA:
21.08
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3al0 GLUTAMYL-TRNA(GLN)
AMIDOTRANSFERASE
SUBUNIT A

(Thermotoga
maritima) 		PF01425
(Amidase) 		3 ARG A 367
ARG A 368
ILE A 298
 None
 0.86A 4b7qA-3al0A:
undetectable		 4b7qA-3al0A:
22.51
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3ckz NEURAMINIDASE

(Influenza A
virus) 		PF00064
(Neur) 		3 ARG A 152
ARG A 156
ILE A 222
 ZMR  A 469 (-3.9A)
ZMR  A 469 (-3.4A)
None
 0.90A 4b7qA-3ckzA:
74.1		 4b7qA-3ckzA:
91.17
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3cmg PUTATIVE
BETA-GALACTOSIDASE

(Bacteroides
fragilis) 		PF00703
(Glyco_hydro_2)
PF02836
(Glyco_hydro_2_C)
PF02837
(Glyco_hydro_2_N)
PF16355
(DUF4982) 		3 ARG A 151
ARG A 119
ILE A  84
 None
 0.88A 4b7qA-3cmgA:
undetectable		 4b7qA-3cmgA:
20.68
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3cyq CHEMOTAXIS PROTEIN
MOTB

(Helicobacter
pylori) 		no annotation 3 ARG B 226
ARG B 183
ILE B 212
 None
 0.89A 4b7qA-3cyqB:
undetectable		 4b7qA-3cyqB:
14.07
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3cze SUCROSE HYDROLASE

(Xanthomonas
citri) 		PF00128
(Alpha-amylase) 		3 ARG A 545
ARG A 530
ILE A 548
 None
 0.85A 4b7qA-3czeA:
undetectable		 4b7qA-3czeA:
18.88
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3e02 UNCHARACTERIZED
PROTEIN DUF849

(Paraburkholderia
xenovorans) 		PF05853
(BKACE) 		3 ARG A 280
ARG A 277
ILE A 290
 None
EDO  A 321 (-4.2A)
None
 0.80A 4b7qA-3e02A:
undetectable		 4b7qA-3e02A:
21.92
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3e02 UNCHARACTERIZED
PROTEIN DUF849

(Paraburkholderia
xenovorans) 		PF05853
(BKACE) 		3 ARG A 280
ARG A 281
ILE A 290
 None
EDO  A 321 (-3.1A)
None
 0.91A 4b7qA-3e02A:
undetectable		 4b7qA-3e02A:
21.92
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3g7q VALINE-PYRUVATE
AMINOTRANSFERASE

(Salmonella
enterica) 		PF00155
(Aminotran_1_2) 		3 ARG A 358
ARG A 362
ILE A 350
 None
 0.89A 4b7qA-3g7qA:
undetectable		 4b7qA-3g7qA:
20.27
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3gf7 GLUTACONYL-COA
DECARBOXYLASE
SUBUNIT A

([Clostridium]
symbiosum) 		PF01039
(Carboxyl_trans) 		3 ARG A 166
ARG A 165
ILE A 131
 None
 0.75A 4b7qA-3gf7A:
undetectable		 4b7qA-3gf7A:
22.30
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3i3f HYPOTHETICAL PROTEIN

(Giardia
intestinalis) 		PF01042
(Ribonuc_L-PSP) 		3 ARG A 118
ARG A 115
ILE A  87
 LEA  A 142 (-3.8A)
None
None
 0.94A 4b7qA-3i3fA:
undetectable		 4b7qA-3i3fA:
14.71
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3i44 ALDEHYDE
DEHYDROGENASE

(Bartonella
henselae) 		PF00171
(Aldedh) 		3 ARG A 272
ARG A 269
ILE A 305
 None
 0.84A 4b7qA-3i44A:
undetectable		 4b7qA-3i44A:
21.61
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ij3 CYTOSOL
AMINOPEPTIDASE

(Coxiella
burnetii) 		PF00883
(Peptidase_M17) 		3 ARG A 271
ARG A 273
ILE A 216
 PG4  A 472 ( 3.5A)
None
None
 0.89A 4b7qA-3ij3A:
undetectable		 4b7qA-3ij3A:
20.04
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3iz3 STRUCTURAL PROTEIN
VP1

(Cypovirus 1) 		no annotation 3 ARG B1021
ARG B1020
ILE B1035
 None
 0.91A 4b7qA-3iz3B:
undetectable		 4b7qA-3iz3B:
15.88
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3jv7 ADH-A

(Rhodococcus
ruber) 		PF00107
(ADH_zinc_N)
PF08240
(ADH_N) 		3 ARG A 333
ARG A 330
ILE A  42
 None
 0.87A 4b7qA-3jv7A:
undetectable		 4b7qA-3jv7A:
21.08
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3k28 GLUTAMATE-1-SEMIALDE
HYDE 2,1-AMINOMUTASE
2

(Bacillus
anthracis) 		PF00202
(Aminotran_3) 		3 ARG A 130
ARG A 127
ILE A 138
 None
 0.75A 4b7qA-3k28A:
undetectable		 4b7qA-3k28A:
20.80
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3lm8 THIAMINE
PYROPHOSPHOKINASE

(Bacillus
subtilis) 		PF04263
(TPK_catalytic)
PF04265
(TPK_B1_binding) 		3 ARG A 211
ARG A 128
ILE A 155
 None
 0.91A 4b7qA-3lm8A:
undetectable		 4b7qA-3lm8A:
19.45
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3t5q NUCLEOPROTEIN

(Mopeia Lassa
virus
reassortant 29) 		PF00843
(Arena_nucleocap) 		3 ARG A  55
ARG A  52
ILE A 241
 None
 0.89A 4b7qA-3t5qA:
undetectable		 4b7qA-3t5qA:
19.34
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3ti8 NEURAMINIDASE

(Influenza A
virus) 		PF00064
(Neur) 		3 ARG A 152
ARG A 156
ILE A 222
 LNV  A 901 (-4.0A)
LNV  A 901 (-4.0A)
None
 0.22A 4b7qA-3ti8A:
69.7		 4b7qA-3ti8A:
48.63
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3tia NEURAMINIDASE

(Influenza A
virus) 		PF00064
(Neur) 		3 ARG A 152
ARG A 156
ILE A 222
 LNV  A 801 (-3.9A)
LNV  A 801 (-4.0A)
None
 0.21A 4b7qA-3tiaA:
63.8		 4b7qA-3tiaA:
45.55
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ako SPORE COAT PROTEIN A

(Bacillus
subtilis) 		PF00394
(Cu-oxidase)
PF07731
(Cu-oxidase_2)
PF07732
(Cu-oxidase_3) 		3 ARG A 476
ARG A 434
ILE A 408
 None
 0.93A 4b7qA-4akoA:
undetectable		 4b7qA-4akoA:
21.56
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4b2n 70 KDA PROTEIN

(Xanthomonas sp.
35Y) 		no annotation 3 ARG A 626
ARG A 246
ILE A 618
 None
 0.95A 4b7qA-4b2nA:
undetectable		 4b7qA-4b2nA:
21.18
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ciu CHAPERONE PROTEIN
CLPB

(Escherichia
coli) 		PF00004
(AAA)
PF07724
(AAA_2)
PF10431
(ClpB_D2-small) 		3 ARG A 491
ARG A 490
ILE A 224
 None
 0.86A 4b7qA-4ciuA:
undetectable		 4b7qA-4ciuA:
17.19
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4cpn NEURAMINIDASE

(Influenza B
virus) 		PF00064
(Neur) 		3 ARG A 149
ARG A 153
ILE A 220
 ZMR  A 700 (-4.0A)
ZMR  A 700 (-4.2A)
None
 0.25A 4b7qA-4cpnA:
53.2		 4b7qA-4cpnA:
34.36
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4e77 GLUTAMATE-1-SEMIALDE
HYDE 2,1-AMINOMUTASE

(Yersinia pestis) 		PF00202
(Aminotran_3) 		3 ARG A 127
ARG A 124
ILE A 135
 None
 0.89A 4b7qA-4e77A:
undetectable		 4b7qA-4e77A:
20.72
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4fj6 GLYCOSIDE HYDROLASE
FAMILY 33, CANDIDATE
SIALIDASE

(Parabacteroides
distasonis) 		PF13859
(BNR_3)
PF14873
(BNR_assoc_N) 		3 ARG A  45
ARG A  26
ILE A 138
 None
PO4  A 606 (-2.7A)
None
 0.87A 4b7qA-4fj6A:
5.2		 4b7qA-4fj6A:
22.70
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4g1t INTERFERON-INDUCED
PROTEIN WITH
TETRATRICOPEPTIDE
REPEATS 2

(Homo sapiens) 		PF13181
(TPR_8) 		3 ARG A 292
ARG A 258
ILE A 339
 None
 0.94A 4b7qA-4g1tA:
undetectable		 4b7qA-4g1tA:
20.45
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4g88 OUTER MEMBRANE
PROTEIN OMP38

(Acinetobacter
baumannii) 		PF00691
(OmpA) 		3 ARG A 330
ARG A 286
ILE A 316
 None
API  A 401 (-3.0A)
None
 0.83A 4b7qA-4g88A:
undetectable		 4b7qA-4g88A:
13.19
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4glx DNA LIGASE

(Escherichia
coli) 		PF01653
(DNA_ligase_aden)
PF03119
(DNA_ligase_ZBD)
PF03120
(DNA_ligase_OB)
PF12826
(HHH_2)
PF14520
(HHH_5) 		3 ARG A  40
ARG A  43
ILE A  73
 None
 0.85A 4b7qA-4glxA:
undetectable		 4b7qA-4glxA:
20.26
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4gx0 TRKA DOMAIN PROTEIN

(Geobacter
sulfurreducens) 		PF02080
(TrkA_C)
PF02254
(TrkA_N)
PF07885
(Ion_trans_2) 		3 ARG A 253
ARG A 249
ILE A 257
 None
 0.84A 4b7qA-4gx0A:
undetectable		 4b7qA-4gx0A:
21.78
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4h53 NEURAMINIDASE

(Influenza A
virus) 		PF00064
(Neur) 		3 ARG A 152
ARG A 156
ILE A 222
 SLB  A 512 (-3.8A)
None
None
 0.22A 4b7qA-4h53A:
63.9		 4b7qA-4h53A:
41.63
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4hzz NEURAMINIDASE

(Influenza A
virus) 		PF00064
(Neur) 		3 ARG A 152
ARG A 156
ILE A 222
 G39  A 509 (-3.9A)
None
G39  A 509 ( 4.1A)
 0.22A 4b7qA-4hzzA:
63.3		 4b7qA-4hzzA:
40.42
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4i2w PROTEIN UNC-45

(Caenorhabditis
elegans) 		PF11701
(UNC45-central) 		3 ARG A  60
ARG A  57
ILE A  25
 None
 0.87A 4b7qA-4i2wA:
undetectable		 4b7qA-4i2wA:
17.86
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ifd EXOSOME COMPLEX
COMPONENT RRP43
EXOSOME COMPLEX
EXONUCLEASE RRP6

(Saccharomyces
cerevisiae) 		PF01138
(RNase_PH)
no annotation 		3 ARG C  40
ARG K 602
ILE C 331
 None
 0.82A 4b7qA-4ifdC:
undetectable		 4b7qA-4ifdC:
20.79
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4kw3 NS1

(Human bocavirus) 		no annotation 3 ARG A 217
ARG A 257
ILE A 219
 None
 0.89A 4b7qA-4kw3A:
undetectable		 4b7qA-4kw3A:
19.57
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4mju NEURAMINIDASE

(Influenza A
virus) 		PF00064
(Neur) 		3 ARG A 152
ARG A 156
ILE A 222
 27S  A 501 (-4.2A)
None
27S  A 501 ( 4.6A)
 0.69A 4b7qA-4mjuA:
67.4		 4b7qA-4mjuA:
53.96
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4n80 UNCHARACTERIZED
PROTEIN

(Pseudomonas
aeruginosa) 		no annotation 3 ARG A  84
ARG A  80
ILE A 109
 None
 0.84A 4b7qA-4n80A:
undetectable		 4b7qA-4n80A:
20.29
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4p05 ARYLSULFATE
SULFOTRANSFERASE
ASST

(Escherichia
coli) 		PF05935
(Arylsulfotrans)
PF17425
(Arylsulfotran_N) 		3 ARG A 283
ARG A 374
ILE A 282
 None
 0.89A 4b7qA-4p05A:
9.4		 4b7qA-4p05A:
21.68
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4qn3 NEURAMINIDASE

(Influenza A
virus) 		PF00064
(Neur) 		3 ARG A  70
ARG A  74
ILE A 141
 None
 0.28A 4b7qA-4qn3A:
63.7		 4b7qA-4qn3A:
38.82
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4wj3 GLUTAMYL-TRNA(GLN)
AMIDOTRANSFERASE
SUBUNIT A

(Pseudomonas
aeruginosa) 		PF01425
(Amidase) 		3 ARG A 380
ARG A 381
ILE A 310
 None
 0.94A 4b7qA-4wj3A:
undetectable		 4b7qA-4wj3A:
22.45
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4xkz VALINE-TRNA LIGASE

(Pseudomonas
aeruginosa) 		PF08264
(Anticodon_1) 		3 ARG A 810
ARG A 807
ILE A 821
 None
PGE  A 906 (-3.1A)
None
 0.87A 4b7qA-4xkzA:
undetectable		 4b7qA-4xkzA:
19.03
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ah5 LEUCINE--TRNA LIGASE

(Agrobacterium
tumefaciens) 		PF00133
(tRNA-synt_1)
PF08264
(Anticodon_1)
PF13603
(tRNA-synt_1_2) 		3 ARG A 792
ARG A 796
ILE A 765
 G  C  46 ( 4.7A)
None
None
 0.94A 4b7qA-5ah5A:
undetectable		 4b7qA-5ah5A:
19.78
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5b7i CRISPR-ASSOCIATED
NUCLEASE/HELICASE
CAS3 SUBTYPE
I-F/YPEST

(Pseudomonas
aeruginosa) 		no annotation 3 ARG A 936
ARG A 935
ILE A 583
 None
 0.78A 4b7qA-5b7iA:
undetectable		 4b7qA-5b7iA:
17.44
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5bw0 TYPE II SECRETION
SYSTEM PROTEIN J

(Pseudomonas
aeruginosa) 		PF11612
(T2SSJ) 		3 ARG A 112
ARG A 110
ILE A  89
 None
 0.93A 4b7qA-5bw0A:
2.3		 4b7qA-5bw0A:
15.30
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5cde PROLINE DIPEPTIDASE

(Xanthomonas
campestris) 		PF00557
(Peptidase_M24)
PF01321
(Creatinase_N) 		3 ARG A  40
ARG A  44
ILE A  36
 None
 0.93A 4b7qA-5cdeA:
undetectable		 4b7qA-5cdeA:
20.40
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ej1 PUTATIVE CELLULOSE
SYNTHASE

(Rhodobacter
sphaeroides) 		PF03170
(BcsB) 		3 ARG B 334
ARG B 158
ILE B 421
 None
 0.77A 4b7qA-5ej1B:
undetectable		 4b7qA-5ej1B:
19.50
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5fl3 PILI RETRACTION
PROTEIN PILT

(Thermus
thermophilus) 		PF00437
(T2SSE) 		3 ARG A 263
ARG A 260
ILE A 251
 None
 0.94A 4b7qA-5fl3A:
undetectable		 4b7qA-5fl3A:
20.89
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5h16 PHOSPHOPANTETHEINE
ADENYLYLTRANSFERASE

(Acinetobacter
baumannii) 		PF01467
(CTP_transf_like) 		3 ARG A  52
ARG A 134
ILE A  37
 None
CIT  A 201 ( 4.0A)
None
 0.93A 4b7qA-5h16A:
undetectable		 4b7qA-5h16A:
15.60
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5h3w FIBRONECTIN/FIBRINOG
EN BINDING PROTEIN

(Streptococcus
suis) 		PF05670
(DUF814)
PF05833
(FbpA) 		3 ARG A 151
ARG A 152
ILE A 157
 None
 0.90A 4b7qA-5h3wA:
undetectable		 4b7qA-5h3wA:
20.42
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5jki PUTATIVE LIPID
PHOSPHATE
PHOSPHATASE YODM

(Bacillus
subtilis) 		PF01569
(PAP2) 		3 ARG A 101
ARG A 103
ILE A  18
 None
WO4  A 300 (-2.3A)
None
 0.86A 4b7qA-5jkiA:
undetectable		 4b7qA-5jkiA:
18.30
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ldr BETA-D-GALACTOSIDASE

(Paracoccus sp.
32d) 		PF00703
(Glyco_hydro_2)
PF02836
(Glyco_hydro_2_C)
PF02837
(Glyco_hydro_2_N) 		3 ARG B 312
ARG B 279
ILE B 316
 None
 0.94A 4b7qA-5ldrB:
undetectable		 4b7qA-5ldrB:
18.54
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5m2n ELONGATOR COMPLEX
PROTEIN 2

(Saccharomyces
cerevisiae) 		PF00400
(WD40) 		3 ARG A 626
ARG A 578
ILE A 655
 None
 0.68A 4b7qA-5m2nA:
6.5		 4b7qA-5m2nA:
20.57
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5o5j 30S RIBOSOMAL
PROTEIN S4

(Mycolicibacterium
smegmatis) 		PF00163
(Ribosomal_S4)
PF01479
(S4) 		3 ARG D 174
ARG D 172
ILE D 137
 None
 0.71A 4b7qA-5o5jD:
undetectable		 4b7qA-5o5jD:
17.91
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5sup ATP-DEPENDENT RNA
HELICASE SUB2

(Saccharomyces
cerevisiae) 		PF00270
(DEAD)
PF00271
(Helicase_C) 		3 ARG A 227
ARG A 228
ILE A 257
 None
 0.84A 4b7qA-5supA:
undetectable		 4b7qA-5supA:
21.24
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5suq ATP-DEPENDENT RNA
HELICASE SUB2

(Saccharomyces
cerevisiae) 		PF00270
(DEAD)
PF00271
(Helicase_C) 		3 ARG A 227
ARG A 228
ILE A 257
 None
KEG  A 502 (-3.8A)
None
 0.84A 4b7qA-5suqA:
undetectable		 4b7qA-5suqA:
21.28
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5vcs ALPHA-1,6-MANNOSYL-G
LYCOPROTEIN
2-BETA-N-ACETYLGLUCO
SAMINYLTRANSFERASE

(Homo sapiens) 		no annotation 3 ARG A 444
ARG A 445
ILE A 332
 None
 0.86A 4b7qA-5vcsA:
undetectable		 4b7qA-5vcsA:
11.44
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5vtm TYPE II SECRETION
SYSTEM PROTEIN J

(Pseudomonas
aeruginosa) 		no annotation 3 ARG W 112
ARG W 110
ILE W  89
 None
 0.93A 4b7qA-5vtmW:
undetectable		 4b7qA-5vtmW:
9.01
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5w4a P-GRANULE SCAFFOLD

(Caenorhabditis
japonica) 		no annotation 3 ARG A  15
ARG A 200
ILE A   8
 None
 0.60A 4b7qA-5w4aA:
undetectable		 4b7qA-5w4aA:
10.18
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5wtp OMPA FAMILY PROTEIN

(Capnocytophaga
gingivalis) 		no annotation 3 ARG A 422
ARG A 382
ILE A 418
 SO4  A 509 (-3.7A)
None
SO4  A 509 (-3.8A)
 0.91A 4b7qA-5wtpA:
undetectable		 4b7qA-5wtpA:
8.89
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5wyb PROBABLE ENOYL-COA
HYDRATASE/ISOMERASE

(Pseudomonas
aeruginosa) 		no annotation 3 ARG B  97
ARG B  96
ILE B  46
 None
 0.85A 4b7qA-5wybB:
undetectable		 4b7qA-5wybB:
8.64
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5xtw MACROPHAGE MANNOSE
RECEPTOR 1

(Homo sapiens) 		no annotation 3 ARG A 151
ARG A  23
ILE A 141
 None
 0.88A 4b7qA-5xtwA:
undetectable		 4b7qA-5xtwA:
11.41
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5zb8 PFUENDOQ

(Pyrococcus
furiosus) 		no annotation 3 ARG A 240
ARG A 280
ILE A 369
 None
 0.91A 4b7qA-5zb8A:
undetectable		 4b7qA-5zb8A:
10.45
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6br6 NEURAMINIDASE

(Influenza A
virus) 		no annotation 3 ARG A 152
ARG A 156
ILE A 222
 E3M  A 511 (-3.8A)
None
E3M  A 511 ( 4.3A)
 0.28A 4b7qA-6br6A:
64.1		 4b7qA-6br6A:
11.31
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6c01 ECTONUCLEOTIDE
PYROPHOSPHATASE/PHOS
PHODIESTERASE FAMILY
MEMBER 3

(Homo sapiens) 		no annotation 3 ARG A 407
ARG A 405
ILE A 411
 NAG  A 904 (-3.7A)
None
NAG  A 904 (-4.6A)
 0.72A 4b7qA-6c01A:
undetectable		 4b7qA-6c01A:
13.23
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6cri

() 		no annotation 3 ARG G  15
ARG G  12
ILE S 104
 None
 0.81A 4b7qA-6criG:
undetectable		 4b7qA-6criG:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6f2t -

(-) 		no annotation 3 ARG A 407
ARG A 405
ILE A 411
 NAG  A1005 (-4.1A)
None
None
 0.79A 4b7qA-6f2tA:
undetectable		 4b7qA-6f2tA:
undetectable