SIMILAR PATTERNS OF AMINO ACIDS FOR 4B53_B_ACTB1445_0

List of similar pattern of amino acids derived from ASSAM search

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click link on the last column to view superposed patterns of amino acids in NGL viewer)
(Note that only 3-12 residue patterns can be used for ASSAM searches)
Filter list by:
Hit Macromolecule/
Organism		 Pfam Res. Interface HETATM RMSD Dali Z-score Seq. Identity (%) View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1e5f METHIONINE
GAMMA-LYASE

(Trichomonas
vaginalis) 		PF01053
(Cys_Met_Meta_PP) 		3 GLU A 267
GLY A 341
SER A 310
 None
 0.63A 4b53B-1e5fA:
undetectable		 4b53B-1e5fA:
12.34
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1gxn PECTATE LYASE

(Cellvibrio
japonicus) 		PF09492
(Pec_lyase) 		3 GLU A 624
GLY A 628
SER A 622
 None
 0.67A 4b53B-1gxnA:
undetectable		 4b53B-1gxnA:
14.97
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1mco IGG1 MCG INTACT
ANTIBODY (HEAVY
CHAIN)

(Homo sapiens) 		PF07654
(C1-set)
PF07686
(V-set) 		3 GLU H 367
GLY H 370
SER H 409
 None
 0.61A 4b53B-1mcoH:
5.7		 4b53B-1mcoH:
23.40
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1nl3 PREPROTEIN
TRANSLOCASE SECA 1
SUBUNIT

(Mycobacterium
tuberculosis) 		PF01043
(SecA_PP_bind)
PF07516
(SecA_SW)
PF07517
(SecA_DEAD) 		3 GLU A 825
GLY A 821
SER A 289
 None
 0.70A 4b53B-1nl3A:
undetectable		 4b53B-1nl3A:
7.35
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1okg POSSIBLE
3-MERCAPTOPYRUVATE
SULFURTRANSFERASE

(Leishmania
major) 		PF00581
(Rhodanese)
PF09122
(DUF1930) 		3 GLU A 283
GLY A 279
SER A  71
 None
 0.65A 4b53B-1okgA:
undetectable		 4b53B-1okgA:
15.58
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1qb4 PHOSPHOENOLPYRUVATE
CARBOXYLASE

(Escherichia
coli) 		PF00311
(PEPcase) 		3 GLU A 398
GLY A 255
SER A 475
 None
 0.63A 4b53B-1qb4A:
undetectable		 4b53B-1qb4A:
9.11
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1s9v HLA CLASS II
HISTOCOMPATIBILITY
ANTIGEN, DQ(3) ALPHA
CHAIN

(Homo sapiens) 		PF00993
(MHC_II_alpha)
PF07654
(C1-set) 		3 GLU A  25
GLY A  28
SER A   8
 None
 0.51A 4b53B-1s9vA:
15.4		 4b53B-1s9vA:
19.90
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1sgl TRICHOMAGLIN

(Trichosanthes
lepiniana) 		PF00445
(Ribonuclease_T2) 		3 GLU A  95
GLY A  99
SER A  89
 None
 0.71A 4b53B-1sglA:
undetectable		 4b53B-1sglA:
18.96
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1v2y 3300001G02RIK
PROTEIN

(Mus musculus) 		no annotation 3 GLU A  70
GLY A  83
SER A  67
 None
 0.67A 4b53B-1v2yA:
undetectable		 4b53B-1v2yA:
21.93
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1w1f TYROSINE-PROTEIN
KINASE LYN

(Homo sapiens) 		PF00018
(SH3_1) 		3 GLU A  43
GLY A  42
SER A  60
 None
 0.68A 4b53B-1w1fA:
undetectable		 4b53B-1w1fA:
23.36
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1x9j PROBABLE BUTYRATE
KINASE 2

(Thermotoga
maritima) 		PF00871
(Acetate_kinase) 		3 GLU A 213
GLY A 185
SER A 254
 None
 0.57A 4b53B-1x9jA:
undetectable		 4b53B-1x9jA:
15.10
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1x9s DNA POLYMERASE

(Escherichia
virus T7) 		PF00476
(DNA_pol_A) 		3 GLU A 126
GLY A 129
SER A  95
 None
 0.71A 4b53B-1x9sA:
undetectable		 4b53B-1x9sA:
8.92
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1z68 FIBROBLAST
ACTIVATION PROTEIN,
ALPHA SUBUNIT

(Homo sapiens) 		PF00326
(Peptidase_S9)
PF00930
(DPPIV_N) 		3 GLU A 340
GLY A 348
SER A 316
 None
 0.45A 4b53B-1z68A:
undetectable		 4b53B-1z68A:
11.19
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2a35 HYPOTHETICAL PROTEIN
PA4017

(Pseudomonas
aeruginosa) 		PF08732
(HIM1) 		3 GLU A 133
GLY A 130
SER A 113
 None
 0.69A 4b53B-2a35A:
undetectable		 4b53B-2a35A:
17.21
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2bka TAT-INTERACTING
PROTEIN TIP30

(Homo sapiens) 		PF13460
(NAD_binding_10) 		3 GLU A 151
GLY A 148
SER A 131
 None
 0.70A 4b53B-2bkaA:
undetectable		 4b53B-2bkaA:
19.74
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2br4 CEPHALOSPORIN
HYDROXYLASE CMCI

(Streptomyces
clavuligerus) 		PF04989
(CmcI) 		3 GLU A  87
GLY A  89
SER A  95
 SAM  A 301 (-3.0A)
SAM  A 301 (-3.3A)
SAM  A 301 (-3.0A)
 0.59A 4b53B-2br4A:
undetectable		 4b53B-2br4A:
17.23
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2cjt UNC-13 HOMOLOG A

(Rattus
norvegicus) 		PF00168
(C2) 		3 GLU A  90
GLY A  92
SER A  88
 None
EDO  A1132 (-3.5A)
None
 0.68A 4b53B-2cjtA:
2.9		 4b53B-2cjtA:
22.54
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2d4a MALATE DEHYDROGENASE

(Aeropyrum
pernix) 		no annotation 3 GLU B 262
GLY B 170
SER B 247
 None
 0.66A 4b53B-2d4aB:
undetectable		 4b53B-2d4aB:
13.96
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2eo5 419AA LONG
HYPOTHETICAL
AMINOTRANSFERASE

(Sulfurisphaera
tokodaii) 		PF00202
(Aminotran_3) 		3 GLU A 224
GLY A 223
SER A 152
 None
 0.69A 4b53B-2eo5A:
undetectable		 4b53B-2eo5A:
12.59
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2g5t DIPEPTIDYL PEPTIDASE
4

(Homo sapiens) 		PF00326
(Peptidase_S9)
PF00930
(DPPIV_N) 		3 GLU A 347
GLY A 355
SER A 323
 None
 0.59A 4b53B-2g5tA:
undetectable		 4b53B-2g5tA:
11.85
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2gux GRIFFITHSIN

(Griffithsia) 		PF01419
(Jacalin) 		3 GLU A  75
GLY A  79
SER A  59
 None
 0.50A 4b53B-2guxA:
undetectable		 4b53B-2guxA:
20.55
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2h2q BIFUNCTIONAL
DIHYDROFOLATE
REDUCTASE-THYMIDYLAT
E SYNTHASE

(Trypanosoma
cruzi) 		PF00186
(DHFR_1)
PF00303
(Thymidylat_synt) 		3 GLU A 415
GLY A 454
SER A 412
 None
 0.66A 4b53B-2h2qA:
undetectable		 4b53B-2h2qA:
11.30
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2hr2 HYPOTHETICAL PROTEIN

(Chlorobaculum
tepidum) 		PF12968
(DUF3856) 		3 GLU A  64
GLY A  61
SER A 106
 GOL  A 159 (-3.5A)
None
GOL  A 159 ( 4.4A)
 0.69A 4b53B-2hr2A:
undetectable		 4b53B-2hr2A:
21.52
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2it1 362AA LONG
HYPOTHETICAL
MALTOSE/MALTODEXTRIN
TRANSPORT
ATP-BINDING PROTEIN

(Pyrococcus
horikoshii) 		PF00005
(ABC_tran) 		3 GLU A 299
GLY A 334
SER A 315
 None
 0.47A 4b53B-2it1A:
undetectable		 4b53B-2it1A:
15.56
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2jex REGULATORY PROTEIN
E2

(Deltapapillomavirus
4) 		PF00508
(PPV_E2_N) 		3 GLU A 120
GLY A 123
SER A 187
 None
 0.70A 4b53B-2jexA:
undetectable		 4b53B-2jexA:
20.95
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2kue SERINE/THREONINE-PRO
TEIN KINASE PKNB

(Mycobacterium
tuberculosis) 		PF03793
(PASTA) 		3 GLU A 533
GLY A 502
SER A 556
 None
 0.70A 4b53B-2kueA:
undetectable		 4b53B-2kueA:
27.27
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2nn3 CASPASE-1

(Spodoptera
frugiperda) 		PF00656
(Peptidase_C14) 		3 GLU C  69
GLY C  81
SER C  78
 None
 0.60A 4b53B-2nn3C:
undetectable		 4b53B-2nn3C:
15.93
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2oae DIPEPTIDYL PEPTIDASE
4

(Rattus
norvegicus) 		PF00326
(Peptidase_S9)
PF00930
(DPPIV_N) 		3 GLU A 345
GLY A 353
SER A 321
 None
 0.67A 4b53B-2oaeA:
undetectable		 4b53B-2oaeA:
8.57
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2p24 H-2 CLASS II
HISTOCOMPATIBILITY
ANTIGEN, A-U ALPHA
CHAIN

(Mus musculus) 		PF00993
(MHC_II_alpha)
PF07654
(C1-set) 		3 GLU A  25
GLY A  28
SER A   8
 None
 0.44A 4b53B-2p24A:
15.4		 4b53B-2p24A:
17.99
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2pgw MUCONATE
CYCLOISOMERASE

(Sinorhizobium
meliloti) 		PF02746
(MR_MLE_N)
PF13378
(MR_MLE_C) 		3 GLU A  40
GLY A  44
SER A   7
 None
 0.46A 4b53B-2pgwA:
undetectable		 4b53B-2pgwA:
12.43
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2q3x REGULATING SYNAPTIC
MEMBRANE EXOCYTOSIS
PROTEIN 1

(Rattus
norvegicus) 		PF00168
(C2) 		3 GLU A1479
GLY A1468
SER A1530
 None
 0.66A 4b53B-2q3xA:
3.7		 4b53B-2q3xA:
24.40
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2qoj INTRON-ENCODED DNA
ENDONUCLEASE I-ANII

(Aspergillus
nidulans) 		PF00961
(LAGLIDADG_1) 		3 GLU Z  31
GLY Z  33
SER Z  20
 None
 0.69A 4b53B-2qojZ:
undetectable		 4b53B-2qojZ:
19.17
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2x3c TOXIC EXTRACELLULAR
ENDOPEPTIDASE

(Aeromonas
salmonicida) 		PF14521
(Aspzincin_M35) 		3 GLU A  71
GLY A  74
SER A 122
 None
 0.60A 4b53B-2x3cA:
2.0		 4b53B-2x3cA:
16.93
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2xdg GROWTH
HORMONE-RELEASING
HORMONE RECEPTOR

(Homo sapiens) 		PF02793
(HRM) 		3 GLU A  88
GLY A  90
SER A  86
 None
 0.39A 4b53B-2xdgA:
undetectable		 4b53B-2xdgA:
23.01
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2yh0 SPLICING FACTOR U2AF
65 KDA SUBUNIT

(Homo sapiens) 		PF00076
(RRM_1) 		3 GLU A 277
GLY A 183
SER A 281
 None
 0.65A 4b53B-2yh0A:
undetectable		 4b53B-2yh0A:
20.41
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2yjq CEL44C

(Paenibacillus
polymyxa) 		PF12891
(Glyco_hydro_44) 		3 GLU A 364
GLY A 363
SER A 360
 None
 0.64A 4b53B-2yjqA:
undetectable		 4b53B-2yjqA:
12.82
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3a55 PROTEIN-GLUTAMINASE

(Chryseobacterium
proteolyticum) 		no annotation 3 GLU A  85
GLY A  87
SER A  83
 None
 0.69A 4b53B-3a55A:
undetectable		 4b53B-3a55A:
17.39
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ada SARCOSINE OXIDASE
BETA SUBUNIT

(Corynebacterium
sp. U-96) 		PF01266
(DAO) 		3 GLU B  82
GLY B 130
SER B  70
 None
 0.67A 4b53B-3adaB:
undetectable		 4b53B-3adaB:
15.01
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ckm YRAM (HI1655)

(Haemophilus
influenzae) 		PF04348
(LppC) 		3 GLU A 510
GLY A 508
SER A 469
 None
None
SO4  A 582 (-3.1A)
 0.70A 4b53B-3ckmA:
undetectable		 4b53B-3ckmA:
15.72
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3dcz PUTATIVE RNFG
SUBUNIT OF ELECTRON
TRANSPORT COMPLEX

(Thermotoga
maritima) 		PF04205
(FMN_bind) 		3 GLU A 220
GLY A 127
SER A 223
 None
 0.63A 4b53B-3dczA:
undetectable		 4b53B-3dczA:
22.84
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3dmy PROTEIN FDRA

(Escherichia
coli) 		PF00549
(Ligase_CoA)
PF02629
(CoA_binding) 		3 GLU A 218
GLY A 219
SER A 316
 None
 0.70A 4b53B-3dmyA:
undetectable		 4b53B-3dmyA:
11.65
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ezo MALONYL COA-ACYL
CARRIER PROTEIN
TRANSACYLASE

(Burkholderia
pseudomallei) 		PF00698
(Acyl_transf_1) 		3 GLU A 271
GLY A 275
SER A 293
 None
 0.66A 4b53B-3ezoA:
undetectable		 4b53B-3ezoA:
14.59
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3g06 SSPH2 (LEUCINE-RICH
REPEAT PROTEIN)

(Salmonella
enterica) 		PF14496
(NEL) 		3 GLU A 750
GLY A 745
SER A 734
 None
 0.62A 4b53B-3g06A:
undetectable		 4b53B-3g06A:
10.36
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3gs2 E3 UBIQUITIN-PROTEIN
LIGASE RING2

(Homo sapiens) 		PF16207
(RAWUL) 		3 GLU A 312
GLY A 252
SER A 315
 ZN  A 334 (-2.2A)
None
ZN  A 334 ( 4.8A)
 0.46A 4b53B-3gs2A:
undetectable		 4b53B-3gs2A:
23.02
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3h90 FERROUS-IRON EFFLUX
PUMP FIEF

(Escherichia
coli) 		PF01545
(Cation_efflux)
PF16916
(ZT_dimer) 		3 GLU A  79
GLY A 240
SER A  63
 None
 0.64A 4b53B-3h90A:
undetectable		 4b53B-3h90A:
15.38
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3hl0 MALEYLACETATE
REDUCTASE

(Agrobacterium
fabrum) 		PF00465
(Fe-ADH) 		3 GLU A  48
GLY A  45
SER A  63
 None
 0.65A 4b53B-3hl0A:
undetectable		 4b53B-3hl0A:
15.73
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3hrd NICOTINATE
DEHYDROGENASE MEDIUM
MOLYBDOPTERIN
SUBUNIT

(Eubacterium
barkeri) 		PF02738
(Ald_Xan_dh_C2) 		3 GLU B 225
GLY B 222
SER B 270
 None
 0.51A 4b53B-3hrdB:
undetectable		 4b53B-3hrdB:
16.97
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3hum PENICILLIN-BINDING
PROTEIN 4

(Staphylococcus
aureus) 		PF00768
(Peptidase_S11)
PF09211
(DUF1958) 		3 GLU A 246
GLY A 254
SER A 251
 None
 0.58A 4b53B-3humA:
undetectable		 4b53B-3humA:
12.33
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3jb9 PRE-MRNA-SPLICING
FACTOR CWF10

(Schizosaccharomyces
pombe) 		PF00009
(GTP_EFTU)
PF00679
(EFG_C)
PF03144
(GTP_EFTU_D2)
PF03764
(EFG_IV)
PF16004
(EFTUD2) 		3 GLU B  82
GLY B  86
SER B  80
 None
 0.65A 4b53B-3jb9B:
undetectable		 4b53B-3jb9B:
6.71
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3k44 PURINE-RICH BINDING
PROTEIN-ALPHA,
ISOFORM B

(Drosophila
melanogaster) 		PF04845
(PurA) 		3 GLU A  73
GLY A  75
SER A  81
 None
 0.62A 4b53B-3k44A:
undetectable		 4b53B-3k44A:
17.58
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3l4k DNA TOPOISOMERASE 2

(Saccharomyces
cerevisiae) 		PF00521
(DNA_topoisoIV)
PF01751
(Toprim)
PF16898
(TOPRIM_C) 		3 GLU A 738
GLY A 737
SER A 729
 None
 0.51A 4b53B-3l4kA:
undetectable		 4b53B-3l4kA:
10.99
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ll1 GRIFFITHSIN

(Griffithsia sp.
Q66D336) 		PF01419
(Jacalin) 		3 GLU A  75
GLY A  79
SER A  59
 None
 0.47A 4b53B-3ll1A:
undetectable		 4b53B-3ll1A:
19.85
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3lyd UNCHARACTERIZED
PROTEIN

(Jonesia
denitrificans) 		PF10738
(Lpp-LpqN) 		3 GLU A 117
GLY A  60
SER A 119
 None
 0.69A 4b53B-3lydA:
undetectable		 4b53B-3lydA:
16.15
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3mg9 TEG12

(uncultured soil
bacterium) 		PF00685
(Sulfotransfer_1) 		3 GLU A 124
GLY A 273
SER A 141
 None
 0.70A 4b53B-3mg9A:
undetectable		 4b53B-3mg9A:
17.59
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3mgb TEG12

(uncultured soil
bacterium) 		PF00685
(Sulfotransfer_1) 		3 GLU A 124
GLY A 273
SER A 141
 None
 0.66A 4b53B-3mgbA:
undetectable		 4b53B-3mgbA:
16.19
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3o6x GLUTAMINE SYNTHETASE

(Bacteroides
fragilis) 		PF00120
(Gln-synt_C)
PF12437
(GSIII_N) 		3 GLU A 330
GLY A 477
SER A 392
 None
 0.70A 4b53B-3o6xA:
undetectable		 4b53B-3o6xA:
9.04
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3oyz MALATE SYNTHASE

(Haloferax
volcanii) 		PF03328
(HpcH_HpaI) 		3 GLU A 161
GLY A 126
SER A 159
 None
 0.54A 4b53B-3oyzA:
undetectable		 4b53B-3oyzA:
12.27
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3pie 5'->3'
EXORIBONUCLEASE
(XRN1)

(Kluyveromyces
lactis) 		PF03159
(XRN_N) 		3 GLU A  58
GLY A 695
SER A  62
 None
 0.68A 4b53B-3pieA:
undetectable		 4b53B-3pieA:
6.66
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3qax PROBABLE ABC
TRANSPORTER
ARGININE-BINDING
PROTEIN ARTJ

(Chlamydia
pneumoniae) 		PF00497
(SBP_bac_3) 		3 GLU A 130
GLY A 126
SER A 143
 None
 0.68A 4b53B-3qaxA:
undetectable		 4b53B-3qaxA:
19.59
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3qum PROSTATE-SPECIFIC
ANTIGEN

(Homo sapiens) 		PF00089
(Trypsin) 		3 GLU P 218
GLY P 216
SER P 195
 None
 0.50A 4b53B-3qumP:
undetectable		 4b53B-3qumP:
17.62
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3r3s OXIDOREDUCTASE

(Salmonella
enterica) 		PF13561
(adh_short_C2) 		3 GLU A  84
GLY A  25
SER A  59
 NAD  A 300 ( 2.8A)
None
MG  A 296 ( 2.1A)
 0.71A 4b53B-3r3sA:
undetectable		 4b53B-3r3sA:
21.10
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3rr6 PUTATIVE
UNCHARACTERIZED
PROTEIN

(Mycobacteroides
abscessus) 		PF01557
(FAA_hydrolase)
PF10370
(DUF2437) 		3 GLU A 188
GLY A 191
SER A 243
 EDO  A 270 ( 4.9A)
None
None
 0.39A 4b53B-3rr6A:
2.3		 4b53B-3rr6A:
16.97
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3u37 ACETYL-XYLAN
ESTERASE EST2A

(Butyrivibrio
proteoclasticus) 		PF13472
(Lipase_GDSL_2) 		3 GLU A 147
GLY A 148
SER A 142
 None
None
ACY  A 401 (-2.8A)
 0.55A 4b53B-3u37A:
2.7		 4b53B-3u37A:
13.54
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4a6o ALPHA-N-ACETYLGLUCOS
AMINIDASE FAMILY
PROTEIN

(Clostridium
perfringens) 		PF00754
(F5_F8_type_C) 		3 GLU A1282
GLY A1286
SER A1314
 None
 0.48A 4b53B-4a6oA:
2.2		 4b53B-4a6oA:
22.01
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4bob ERPP PROTEIN

(Borreliella
burgdorferi) 		PF02471
(OspE) 		3 GLU A 109
GLY A 138
SER A 111
 None
 0.46A 4b53B-4bobA:
undetectable		 4b53B-4bobA:
20.73
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4bqm GLUTAMINASE LIVER
ISOFORM,
MITOCHONDRIAL

(Homo sapiens) 		PF04960
(Glutaminase) 		3 GLU A 384
GLY A 234
SER A 382
 None
 0.65A 4b53B-4bqmA:
undetectable		 4b53B-4bqmA:
17.51
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4bxm ERPC

(Borreliella
burgdorferi) 		PF02471
(OspE) 		3 GLU A 104
GLY A 133
SER A 106
 None
 0.36A 4b53B-4bxmA:
undetectable		 4b53B-4bxmA:
19.05
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4deq NEUROPILIN-1,
VASCULAR ENDOTHELIAL
GROWTH FACTOR A

(Homo sapiens) 		PF00754
(F5_F8_type_C)
PF14554
(VEGF_C) 		3 GLU A  51
GLY A  45
SER A  48
 None
 0.69A 4b53B-4deqA:
undetectable		 4b53B-4deqA:
19.21
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4dol AT1G53520

(Arabidopsis
thaliana) 		PF02431
(Chalcone) 		3 GLU A 131
GLY A 184
SER A 129
 None
 0.62A 4b53B-4dolA:
undetectable		 4b53B-4dolA:
18.89
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4f06 EXTRACELLULAR
LIGAND-BINDING
RECEPTOR

(Rhodopseudomonas
palustris) 		PF13458
(Peripla_BP_6) 		3 GLU A  72
GLY A  32
SER A  80
 None
 0.61A 4b53B-4f06A:
undetectable		 4b53B-4f06A:
15.48
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4fgw GLYCEROL-3-PHOSPHATE
DEHYDROGENASE
[NAD(+)] 1

(Saccharomyces
cerevisiae) 		PF01210
(NAD_Gly3P_dh_N)
PF07479
(NAD_Gly3P_dh_C) 		3 GLU A 256
GLY A 253
SER A 265
 None
 0.71A 4b53B-4fgwA:
undetectable		 4b53B-4fgwA:
15.20
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4fk1 PUTATIVE THIOREDOXIN
REDUCTASE

(Bacillus
anthracis) 		PF07992
(Pyr_redox_2) 		3 GLU C 261
GLY C 242
SER C 260
 None
 0.69A 4b53B-4fk1C:
undetectable		 4b53B-4fk1C:
15.52
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4gfh DNA TOPOISOMERASE 2

(Saccharomyces
cerevisiae) 		PF00204
(DNA_gyraseB)
PF00521
(DNA_topoisoIV)
PF01751
(Toprim)
PF02518
(HATPase_c)
PF16898
(TOPRIM_C) 		3 GLU A 738
GLY A 737
SER A 729
 None
 0.50A 4b53B-4gfhA:
undetectable		 4b53B-4gfhA:
6.57
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4grl MHC CLASS II
HLA-DQ-ALPHA CHAIN

(Homo sapiens) 		PF00993
(MHC_II_alpha)
PF07654
(C1-set) 		3 GLU A  25
GLY A  28
SER A   7
 None
 0.48A 4b53B-4grlA:
15.3		 4b53B-4grlA:
18.95
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4h1x PHOSPHATE-BINDING
PROTEIN PSTS 2

(Streptococcus
pneumoniae) 		PF12849
(PBP_like_2) 		3 GLU A 110
GLY A 113
SER A 269
 None
 0.71A 4b53B-4h1xA:
undetectable		 4b53B-4h1xA:
17.65
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ifs FACT COMPLEX SUBUNIT
SSRP1

(Homo sapiens) 		PF08512
(Rtt106) 		3 GLU A 394
GLY A 398
SER A 375
 None
 0.64A 4b53B-4ifsA:
undetectable		 4b53B-4ifsA:
17.70
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4j38 OUTER SURFACE
PROTEIN E

(Borreliella
burgdorferi) 		PF02471
(OspE) 		3 GLU A 117
GLY A 146
SER A 119
 None
 0.31A 4b53B-4j38A:
undetectable		 4b53B-4j38A:
20.25
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4k1c VACUOLAR CALCIUM ION
TRANSPORTER

(Saccharomyces
cerevisiae) 		PF01699
(Na_Ca_ex) 		3 GLU A 106
GLY A 298
SER A 129
 CA  A 506 ( 4.6A)
None
None
 0.70A 4b53B-4k1cA:
undetectable		 4b53B-4k1cA:
14.11
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ks9 MALONYL-COA
DECARBOXYLASE

(Cupriavidus
metallidurans) 		PF05292
(MCD)
PF17408
(MCD_N) 		3 GLU A 184
GLY A 299
SER A 188
 None
 0.65A 4b53B-4ks9A:
undetectable		 4b53B-4ks9A:
11.81
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4l5h VVTL1

(Vitis vinifera) 		PF00314
(Thaumatin) 		3 GLU A  85
GLY A 157
SER A  73
 None
 0.59A 4b53B-4l5hA:
undetectable		 4b53B-4l5hA:
18.23
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4n5c CARGO-TRANSPORT
PROTEIN YPP1

(Saccharomyces
cerevisiae) 		no annotation 3 GLU A 189
GLY A 429
SER A 192
 None
 0.47A 4b53B-4n5cA:
undetectable		 4b53B-4n5cA:
9.31
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4n90 TUMOR NECROSIS
FACTOR RECEPTOR
SUPERFAMILY MEMBER
10B

(Homo sapiens) 		PF00020
(TNFR_c6) 		3 GLU R 124
GLY R 115
SER R 121
 None
 0.52A 4b53B-4n90R:
undetectable		 4b53B-4n90R:
20.30
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4o01 BACTERIOPHYTOCHROME

(Deinococcus
radiodurans) 		PF00360
(PHY)
PF01590
(GAF)
PF08446
(PAS_2) 		3 GLU A 381
GLY A 380
SER A 421
 None
 0.71A 4b53B-4o01A:
undetectable		 4b53B-4o01A:
11.02
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4o7d GLUTAMINASE KIDNEY
ISOFORM,
MITOCHONDRIAL

(Homo sapiens) 		PF04960
(Glutaminase) 		3 GLU A 451
GLY A 301
SER A 449
 None
 0.62A 4b53B-4o7dA:
undetectable		 4b53B-4o7dA:
16.73
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4p72 PHENYLALANINE--TRNA
LIGASE BETA SUBUNIT

(Pseudomonas
aeruginosa) 		PF01588
(tRNA_bind)
PF03147
(FDX-ACB)
PF03483
(B3_4)
PF03484
(B5) 		3 GLU A 650
GLY A 653
SER A 632
 None
 0.41A 4b53B-4p72A:
undetectable		 4b53B-4p72A:
8.63
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4psj OR464

(synthetic
construct) 		PF12354
(Internalin_N)
PF13516
(LRR_6)
PF13855
(LRR_8) 		3 GLU A 113
GLY A 110
SER A 138
 None
 0.69A 4b53B-4psjA:
undetectable		 4b53B-4psjA:
16.98
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4pxq D-GLUCURONYL C5
EPIMERASE B

(Danio rerio) 		PF06662
(C5-epim_C) 		3 GLU A 467
GLY A 479
SER A 411
 None
 0.67A 4b53B-4pxqA:
undetectable		 4b53B-4pxqA:
11.71
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4rhz CRY37AA1

(Bacillus
thuringiensis) 		no annotation 3 GLU B  52
GLY B  19
SER B  54
 None
 0.57A 4b53B-4rhzB:
2.1		 4b53B-4rhzB:
17.97
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4u8u LINKER L2

(Glossoscolex
paulistus) 		PF00057
(Ldl_recept_a)
PF16915
(Eryth_link_C) 		3 GLU N 219
GLY N 220
SER N 199
 None
 0.70A 4b53B-4u8uN:
undetectable		 4b53B-4u8uN:
18.85
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4v17 CARBOHYDRATE BINDING
MODULE

(Ruminococcus
flavefaciens) 		no annotation 3 GLU A 445
GLY A 444
SER A 580
 None
 0.71A 4b53B-4v17A:
undetectable		 4b53B-4v17A:
20.73
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4xdt FAD:PROTEIN FMN
TRANSFERASE

(Treponema
pallidum) 		PF02424
(ApbE) 		3 GLU A  49
GLY A  18
SER A  53
 FAD  A 401 ( 4.5A)
FAD  A 401 (-3.5A)
FAD  A 401 ( 3.3A)
 0.68A 4b53B-4xdtA:
undetectable		 4b53B-4xdtA:
16.18
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5d3o GLUTAMINASE KIDNEY
ISOFORM,
MITOCHONDRIAL

(Homo sapiens) 		PF04960
(Glutaminase) 		3 GLU A 456
GLY A 306
SER A 454
 None
 0.67A 4b53B-5d3oA:
undetectable		 4b53B-5d3oA:
10.65
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5e9c HEPARANASE

(Homo sapiens) 		PF03662
(Glyco_hydro_79n) 		3 GLU A 225
GLY A 269
SER A 228
 5KV  A 608 (-2.8A)
5KV  A 608 (-3.5A)
None
 0.52A 4b53B-5e9cA:
undetectable		 4b53B-5e9cA:
15.89
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5epg ALDEHYDE OXIDASE

(Homo sapiens) 		PF00111
(Fer2)
PF00941
(FAD_binding_5)
PF01315
(Ald_Xan_dh_C)
PF01799
(Fer2_2)
PF02738
(Ald_Xan_dh_C2)
PF03450
(CO_deh_flav_C) 		3 GLU A 938
GLY A 741
SER A 934
 None
 0.70A 4b53B-5epgA:
undetectable		 4b53B-5epgA:
5.80
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5i2u CELLULASE

(soil metagenome) 		PF00150
(Cellulase) 		3 GLU A 271
GLY A 238
SER A 265
 GOL  A 401 (-2.7A)
GOL  A 402 ( 4.4A)
None
 0.69A 4b53B-5i2uA:
undetectable		 4b53B-5i2uA:
15.51
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5i4e MYOSIN-14,ALPHA-ACTI
NIN A

(Homo sapiens;
Dictyostelium
discoideum) 		PF00063
(Myosin_head)
PF00435
(Spectrin)
PF02736
(Myosin_N) 		3 GLU A 235
GLY A 232
SER A 220
 None
 0.66A 4b53B-5i4eA:
undetectable		 4b53B-5i4eA:
6.90
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5lz6 GOLGI RESIDENT
PROTEIN GCP60
3A

(Homo sapiens;
Aichivirus B) 		PF13897
(GOLD_2)
no annotation 		3 GLU A 401
GLY A 398
SER B   4
 None
 0.60A 4b53B-5lz6A:
2.4		 4b53B-5lz6A:
18.67
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5nbq OUTER SURFACE
PROTEIN E

(Borreliella
burgdorferi) 		no annotation 3 GLU G 117
GLY G 146
SER G 119
 None
 0.66A 4b53B-5nbqG:
undetectable		 4b53B-5nbqG:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5owo CYTOPLASMIC DYNEIN 1
HEAVY CHAIN 1

(Homo sapiens) 		no annotation 3 GLU A  80
GLY A 110
SER A  82
 None
 0.65A 4b53B-5owoA:
undetectable		 4b53B-5owoA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5swi SUGAR HYDROLASE

(Streptococcus
pneumoniae) 		no annotation 3 GLU B 416
GLY B 484
SER B 419
 GOL  B 705 (-4.4A)
None
None
 0.69A 4b53B-5swiB:
undetectable		 4b53B-5swiB:
10.39