SIMILAR PATTERNS OF AMINO ACIDS FOR 4B3Q_A_NVPA999

List of similar pattern of amino acids derived from ASSAM search

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click link on the last column to view superposed patterns of amino acids in NGL viewer)
(Note that only 3-12 residue patterns can be used for ASSAM searches)
Filter list by:
Hit Macromolecule/
Organism		 Pfam Res. Interface HETATM RMSD Dali Z-score Seq. Identity (%) View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1b8g PROTEIN
(1-AMINOCYCLOPROPANE
-1-CARBOXYLATE
SYNTHASE)

(Malus domestica) 		PF00155
(Aminotran_1_2) 		4 LEU A 317
VAL A 282
TYR A 269
LEU A 275
 None
 1.15A 4b3qA-1b8gA:
0.0		 4b3qA-1b8gA:
20.72
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1cjy PROTEIN (CYTOSOLIC
PHOSPHOLIPASE A2)

(Homo sapiens) 		PF00168
(C2)
PF01735
(PLA2_B) 		4 LEU A 237
LYS A 318
LEU A 218
TYR A 238
 None
 1.07A 4b3qA-1cjyA:
0.8		 4b3qA-1cjyA:
21.96
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1f0x D-LACTATE
DEHYDROGENASE

(Escherichia
coli) 		PF01565
(FAD_binding_4)
PF09330
(Lact-deh-memb) 		4 LEU A 481
LYS A 502
VAL A 505
LEU A 456
 None
 1.14A 4b3qA-1f0xA:
4.7		 4b3qA-1f0xA:
22.05
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1g8k ARSENITE OXIDASE

(Alcaligenes
faecalis) 		PF00384
(Molybdopterin)
PF01568
(Molydop_binding) 		4 LEU A 574
TYR A 143
LEU A 151
TYR A 578
 None
 0.75A 4b3qA-1g8kA:
0.0		 4b3qA-1g8kA:
21.29
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ggl PROTEIN (CELLULAR
RETINOL-BINDING
PROTEIN III)

(Homo sapiens) 		PF00061
(Lipocalin) 		4 LEU A 115
VAL A  51
LEU A   4
TYR A   8
 None
 1.01A 4b3qA-1gglA:
0.0		 4b3qA-1gglA:
13.01
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1j6u UDP-N-ACETYLMURAMATE
-ALANINE LIGASE MURC

(Thermotoga
maritima) 		PF01225
(Mur_ligase)
PF02875
(Mur_ligase_C)
PF08245
(Mur_ligase_M) 		4 LEU A 276
VAL A 287
TYR A 282
LEU A 124
 None
 1.15A 4b3qA-1j6uA:
2.7		 4b3qA-1j6uA:
21.56
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1la2 MYO-INOSITOL-1-PHOSP
HATE SYNTHASE

(Saccharomyces
cerevisiae) 		PF01658
(Inos-1-P_synth)
PF07994
(NAD_binding_5) 		4 LEU A 516
LYS A  18
TYR A  32
TYR A  54
 None
 1.13A 4b3qA-1la2A:
0.0		 4b3qA-1la2A:
22.06
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1pto PERTUSSIS TOXIN

(Bordetella
pertussis) 		PF02918
(Pertussis_S2S3)
PF03440
(APT) 		4 LEU B 119
TYR B 157
TYR B 154
TYR B 146
 None
 1.11A 4b3qA-1ptoB:
undetectable		 4b3qA-1ptoB:
15.44
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1pto PERTUSSIS TOXIN

(Bordetella
pertussis) 		PF02918
(Pertussis_S2S3)
PF03440
(APT) 		4 LEU C 119
TYR C 157
TYR C 154
TYR C 146
 None
 0.99A 4b3qA-1ptoC:
undetectable		 4b3qA-1ptoC:
16.79
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1qle CYTOCHROME C OXIDASE
POLYPEPTIDE I-BETA
CYTOCHROME C OXIDASE
POLYPEPTIDE II

(Paracoccus
denitrificans) 		PF00115
(COX1)
PF00116
(COX2)
PF02790
(COX2_TM) 		4 LEU B 155
VAL A  62
TYR A 475
TYR B 154
 None
 1.13A 4b3qA-1qleB:
undetectable		 4b3qA-1qleB:
18.45
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1si1 IRON BINDING PROTEIN
FBPA

(Mannheimia
haemolytica) 		PF13343
(SBP_bac_6) 		4 LEU A 124
TYR A 121
LEU A 115
TYR A 129
 None
 1.11A 4b3qA-1si1A:
undetectable		 4b3qA-1si1A:
22.54
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1vjs ALPHA-AMYLASE

(Bacillus
licheniformis) 		PF00128
(Alpha-amylase)
PF09154
(DUF1939) 		4 LEU A  64
LYS A  47
TYR A 150
TYR A  62
 None
 1.15A 4b3qA-1vjsA:
undetectable		 4b3qA-1vjsA:
22.73
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1vkn N-ACETYL-GAMMA-GLUTA
MYL-PHOSPHATE
REDUCTASE

(Thermotoga
maritima) 		PF01118
(Semialdhyde_dh)
PF02774
(Semialdhyde_dhC) 		4 VAL A 163
TYR A 242
LEU A 154
TYR A 256
 None
 1.03A 4b3qA-1vknA:
undetectable		 4b3qA-1vknA:
20.46
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1w0a ALPHA-HEMOGLOBIN
STABILIZING PROTEIN

(Homo sapiens) 		PF09236
(AHSP) 		4 LEU A  70
TYR A  48
TYR A  51
LEU A  10
 None
 1.15A 4b3qA-1w0aA:
undetectable		 4b3qA-1w0aA:
9.82
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1y9j SEC1 FAMILY DOMAIN
CONTAINING PROTEIN 1

(Rattus
norvegicus) 		PF00995
(Sec1) 		4 LEU A  22
LYS A  39
TYR A  43
LEU A  60
 None
 0.93A 4b3qA-1y9jA:
undetectable		 4b3qA-1y9jA:
15.41
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1yhu HEMOGLOBIN A1 CHAIN

(Riftia
pachyptila) 		PF00042
(Globin) 		4 LEU A  72
VAL A 117
TYR A 134
LEU A  33
 HEM  A 160 (-4.5A)
None
None
None
 0.94A 4b3qA-1yhuA:
undetectable		 4b3qA-1yhuA:
13.15
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ykg SULFITE REDUCTASE
[NADPH] FLAVOPROTEIN
ALPHA-COMPONENT

(Escherichia
coli) 		PF00258
(Flavodoxin_1) 		4 LEU A 204
LYS A  89
VAL A  92
LEU A  81
 None
 1.15A 4b3qA-1ykgA:
undetectable		 4b3qA-1ykgA:
14.63
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1zt2 DNA PRIMASE LARGE
SUBUNIT

(Sulfolobus
solfataricus) 		PF04104
(DNA_primase_lrg) 		4 LYS B 116
VAL B 140
TYR B 145
LEU B 178
 None
 1.03A 4b3qA-1zt2B:
undetectable		 4b3qA-1zt2B:
17.29
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2d2n GIANT HEMOGLOBIN,
A1(B) GLOBIN CHAIN

(Oligobrachia
mashikoi) 		PF00042
(Globin) 		4 LEU A  70
VAL A 115
TYR A 131
LEU A  31
 HEM  A 200 ( 4.6A)
None
None
None
 0.93A 4b3qA-2d2nA:
undetectable		 4b3qA-2d2nA:
13.97
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2grm PRGX

(Enterococcus
faecalis) 		PF01381
(HTH_3) 		4 LEU A 194
VAL A 156
TYR A 153
TYR A 213
 None
 1.14A 4b3qA-2grmA:
undetectable		 4b3qA-2grmA:
20.25
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2hnz REVERSE
TRANSCRIPTASE/RIBONU
CLEASE H

(Human
immunodeficiency
virus 1) 		PF00075
(RNase_H)
PF00078
(RVT_1)
PF06815
(RVT_connect)
PF06817
(RVT_thumb) 		6 LEU A 100
LYS A 103
VAL A 106
TYR A 181
LEU A 234
TYR A 318
 PC0  A 999 ( 3.9A)
None
PC0  A 999 ( 4.8A)
PC0  A 999 (-3.9A)
PC0  A 999 (-4.2A)
PC0  A 999 (-4.3A)
 0.88A 4b3qA-2hnzA:
31.5		 4b3qA-2hnzA:
97.95
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2hnz REVERSE
TRANSCRIPTASE/RIBONU
CLEASE H

(Human
immunodeficiency
virus 1) 		PF00075
(RNase_H)
PF00078
(RVT_1)
PF06815
(RVT_connect)
PF06817
(RVT_thumb) 		6 LEU A 100
LYS A 103
VAL A 106
TYR A 181
TYR A 188
TYR A 318
 PC0  A 999 ( 3.9A)
None
PC0  A 999 ( 4.8A)
PC0  A 999 (-3.9A)
PC0  A 999 (-4.1A)
PC0  A 999 (-4.3A)
 0.87A 4b3qA-2hnzA:
31.5		 4b3qA-2hnzA:
97.95
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2ix8 ELONGATION FACTOR 3A

(Saccharomyces
cerevisiae) 		PF00005
(ABC_tran) 		4 LEU A1581
VAL A1605
TYR A1584
LEU A1566
 None
 1.16A 4b3qA-2ix8A:
undetectable		 4b3qA-2ix8A:
19.01
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2kbg NEURAL CELL ADHESION
MOLECULE 2

(Homo sapiens) 		PF00041
(fn3) 		4 LEU A  20
VAL A  37
TYR A  71
TYR A  39
 None
 1.06A 4b3qA-2kbgA:
undetectable		 4b3qA-2kbgA:
12.60
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2o0a S.CEREVISIAE
CHROMOSOME XVI
READING FRAME ORF
YPL253C

(Saccharomyces
cerevisiae) 		PF16796
(Microtub_bd) 		4 LEU A 390
VAL A 413
TYR A 408
LEU A 619
 None
 0.89A 4b3qA-2o0aA:
undetectable		 4b3qA-2o0aA:
20.18
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2ob1 LEUCINE CARBOXYL
METHYLTRANSFERASE 1

(Saccharomyces
cerevisiae) 		PF04072
(LCM) 		4 LEU A 113
TYR A 124
TYR A 169
LEU A 140
 None
 1.13A 4b3qA-2ob1A:
undetectable		 4b3qA-2ob1A:
20.54
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2p3x POLYPHENOL OXIDASE,
CHLOROPLAST

(Vitis vinifera) 		PF00264
(Tyrosinase)
PF12142
(PPO1_DWL) 		4 LEU A 112
TYR A  90
LEU A 105
TYR A 221
 None
 1.13A 4b3qA-2p3xA:
undetectable		 4b3qA-2p3xA:
19.83
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2p76 GLYCEROPHOSPHORYL
DIESTER
PHOSPHODIESTERASE

(Staphylococcus
aureus) 		PF03009
(GDPD) 		4 LEU A 228
LYS A 171
TYR A 167
LEU A 213
 GOL  A 501 ( 4.3A)
None
None
None
 1.13A 4b3qA-2p76A:
undetectable		 4b3qA-2p76A:
19.61
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2pk9 PHO85 CYCLIN PHO80

(Saccharomyces
cerevisiae) 		PF08613
(Cyclin) 		4 LEU B 217
TYR B 100
TYR B 101
LEU B 134
 None
 1.15A 4b3qA-2pk9B:
undetectable		 4b3qA-2pk9B:
20.14
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2pok PEPTIDASE,
M20/M25/M40 FAMILY

(Streptococcus
pneumoniae) 		PF01546
(Peptidase_M20)
PF07687
(M20_dimer) 		4 LEU A 339
LYS A 347
VAL A 248
TYR A 252
 None
 1.03A 4b3qA-2pokA:
3.9		 4b3qA-2pokA:
22.11
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2vhf UBIQUITIN
CARBOXYL-TERMINAL
HYDROLASE CYLD

(Homo sapiens) 		PF00443
(UCH) 		4 LEU A 752
TYR A 715
LEU A 734
TYR A 947
 None
 1.02A 4b3qA-2vhfA:
undetectable		 4b3qA-2vhfA:
19.59
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2vk4 PYRUVATE
DECARBOXYLASE

(Kluyveromyces
lactis) 		PF00205
(TPP_enzyme_M)
PF02775
(TPP_enzyme_C)
PF02776
(TPP_enzyme_N) 		4 LYS A 436
VAL A 438
TYR A  61
LEU A 462
 None
 1.10A 4b3qA-2vk4A:
undetectable		 4b3qA-2vk4A:
23.61
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2vp1 PERIPLASMIC
IRON-BINDING PROTEIN

(Synechocystis
sp. PCC 6803) 		PF13343
(SBP_bac_6) 		4 LEU A 285
VAL A  57
LEU A  50
TYR A 284
 None
 1.13A 4b3qA-2vp1A:
undetectable		 4b3qA-2vp1A:
21.62
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2wfx HEDGEHOG-INTERACTING
PROTEIN

(Homo sapiens) 		PF07995
(GSDH) 		4 LEU B 266
TYR B 303
LEU B 299
TYR B 265
 None
 0.98A 4b3qA-2wfxB:
undetectable		 4b3qA-2wfxB:
21.47
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2wsj P-COUMARIC ACID
DECARBOXYLASE

(Lactobacillus
plantarum) 		PF05870
(PA_decarbox) 		4 LEU A  79
VAL A  36
TYR A  26
TYR A  38
 IPA  A1179 (-4.4A)
None
IPA  A1179 ( 4.0A)
IPA  A1179 ( 4.5A)
 1.05A 4b3qA-2wsjA:
undetectable		 4b3qA-2wsjA:
15.96
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2xuz IRON-UPTAKE
SYSTEM-BINDING
PROTEIN

(Bacillus
subtilis) 		PF01497
(Peripla_BP_2) 		4 LEU A 101
VAL A  31
TYR A  24
TYR A  29
 None
 1.15A 4b3qA-2xuzA:
undetectable		 4b3qA-2xuzA:
20.78
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2yzs PUTATIVE
UNCHARACTERIZED
PROTEIN

(Aquifex
aeolicus) 		PF01867
(Cas_Cas1) 		4 LEU A  55
VAL A  41
TYR A   5
LEU A  13
 None
 0.96A 4b3qA-2yzsA:
undetectable		 4b3qA-2yzsA:
21.27
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3alx HEMAGGLUTININ,LINKER
,CDW150

(Measles
morbillivirus;
Saguinus
oedipus;
synthetic
construct) 		PF00423
(HN)
PF06214
(SLAM) 		4 LEU A 205
VAL A 234
TYR A 214
TYR A 275
 None
 1.07A 4b3qA-3alxA:
undetectable		 4b3qA-3alxA:
21.25
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3asm RIBONUCLEASE HIII

(Geobacillus
stearothermophilus) 		PF01351
(RNase_HII)
PF11858
(DUF3378) 		4 LYS A 176
VAL A 110
LEU A 184
TYR A 210
 None
 0.94A 4b3qA-3asmA:
4.3		 4b3qA-3asmA:
18.68
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ayx MEMBRANE-BOUND
HYDROGENASE LARGE
SUBUNIT
MEMBRANE-BOUND
HYDROGENASE SMALL
SUBUNIT

(Hydrogenovibrio
marinus) 		PF00374
(NiFeSe_Hases)
PF01058
(Oxidored_q6)
PF14720
(NiFe_hyd_SSU_C) 		4 LEU A 211
VAL B  42
LEU B  54
TYR A 207
 None
 0.97A 4b3qA-3ayxA:
undetectable		 4b3qA-3ayxA:
22.15
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3bhw UNCHARACTERIZED
PROTEIN

(Magnetospirillum
magneticum) 		PF08849
(DUF1819) 		4 LEU A 127
VAL A 152
LEU A  98
TYR A 126
 None
 0.92A 4b3qA-3bhwA:
undetectable		 4b3qA-3bhwA:
16.61
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3cia COLD-ACTIVE
AMINOPEPTIDASE

(Colwellia
psychrerythraea) 		PF01433
(Peptidase_M1)
PF09127
(Leuk-A4-hydro_C) 		4 VAL A 608
TYR A 578
LEU A 595
TYR A 572
 None
 1.14A 4b3qA-3ciaA:
undetectable		 4b3qA-3ciaA:
22.04
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3dfi PSEUDOAGLYCONE
DEACETYLASE DBV21

(Actinoplanes
teichomyceticus) 		PF02585
(PIG-L) 		4 LEU A 244
TYR A 190
TYR A 187
LEU A  22
 None
 1.04A 4b3qA-3dfiA:
undetectable		 4b3qA-3dfiA:
18.33
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3egw RESPIRATORY NITRATE
REDUCTASE 1 ALPHA
CHAIN

(Escherichia
coli) 		PF00384
(Molybdopterin)
PF01568
(Molydop_binding)
PF14710
(Nitr_red_alph_N) 		4 LEU A 716
LYS A 722
TYR A 610
LEU A 731
 None
MD1  A1245 (-3.2A)
None
None
 1.09A 4b3qA-3egwA:
undetectable		 4b3qA-3egwA:
18.45
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3k3d PROTEIN
RV1364C/MT1410

(Mycobacterium
tuberculosis) 		PF08448
(PAS_4) 		4 LEU A  31
VAL A  78
TYR A  72
LEU A 125
 None
 0.98A 4b3qA-3k3dA:
undetectable		 4b3qA-3k3dA:
15.25
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3kv0 HET-C2

(Podospora
anserina) 		PF08718
(GLTP) 		4 LEU A 172
TYR A 186
LEU A 121
TYR A 169
 MLY  A 171 ( 4.1A)
None
None
None
 0.98A 4b3qA-3kv0A:
undetectable		 4b3qA-3kv0A:
17.47
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3kx0 UNCHARACTERIZED
PROTEIN
RV1364C/MT1410

(Mycobacterium
tuberculosis) 		PF08448
(PAS_4) 		4 LEU X  31
VAL X  78
TYR X  72
LEU X 125
 None
 1.04A 4b3qA-3kx0X:
undetectable		 4b3qA-3kx0X:
16.49
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3llv EXOPOLYPHOSPHATASE-R
ELATED PROTEIN

(Archaeoglobus
fulgidus) 		PF02254
(TrkA_N) 		4 LEU A  66
VAL A  74
TYR A   7
TYR A  63
 None
 1.14A 4b3qA-3llvA:
undetectable		 4b3qA-3llvA:
13.39
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3mcx SUSD SUPERFAMILY
PROTEIN

(Bacteroides
thetaiotaomicron) 		PF07980
(SusD_RagB)
PF14322
(SusD-like_3) 		4 TYR A  67
TYR A  91
LEU A 159
TYR A 442
 None
 1.04A 4b3qA-3mcxA:
undetectable		 4b3qA-3mcxA:
21.95
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ntx CYTOPLASMIC
L-ASPARAGINASE I

(Yersinia pestis) 		PF00710
(Asparaginase) 		4 LEU A 239
VAL A 278
TYR A 242
LEU A 289
 None
 1.03A 4b3qA-3ntxA:
undetectable		 4b3qA-3ntxA:
20.85
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3q4g NH(3)-DEPENDENT
NAD(+) SYNTHETASE

(Vibrio cholerae) 		PF02540
(NAD_synthase) 		4 LEU A 244
LYS A 247
VAL A 249
LEU A 257
 None
 1.11A 4b3qA-3q4gA:
undetectable		 4b3qA-3q4gA:
20.88
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3sns LIPOPROTEIN 34

(Escherichia
coli) 		PF06804
(Lipoprotein_18) 		4 LEU A 334
TYR A 280
TYR A 303
LEU A 326
 None
 1.12A 4b3qA-3snsA:
2.6		 4b3qA-3snsA:
11.43
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3tw8 DENN
DOMAIN-CONTAINING
PROTEIN 1B

(Homo sapiens) 		PF02141
(DENN)
PF03455
(dDENN)
PF03456
(uDENN) 		5 LEU A 111
VAL A  17
TYR A 118
LEU A 134
TYR A 108
 None
 1.43A 4b3qA-3tw8A:
undetectable		 4b3qA-3tw8A:
20.21
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3va7 KLLA0E08119P

(Kluyveromyces
lactis) 		PF00289
(Biotin_carb_N)
PF00364
(Biotin_lipoyl)
PF02626
(CT_A_B)
PF02682
(CT_C_D)
PF02785
(Biotin_carb_C)
PF02786
(CPSase_L_D2) 		4 LEU A1663
LYS A1519
VAL A1695
LEU A1523
 None
 1.06A 4b3qA-3va7A:
3.5		 4b3qA-3va7A:
19.72
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3vkg DYNEIN HEAVY CHAIN,
CYTOPLASMIC

(Dictyostelium
discoideum) 		PF03028
(Dynein_heavy)
PF07728
(AAA_5)
PF08393
(DHC_N2)
PF12774
(AAA_6)
PF12775
(AAA_7)
PF12777
(MT)
PF12780
(AAA_8)
PF12781
(AAA_9) 		4 LEU A2431
VAL A2512
TYR A2505
TYR A2430
 None
 1.07A 4b3qA-3vkgA:
undetectable		 4b3qA-3vkgA:
10.26
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3wct A1 GLOBIN CHAIN OF
GIANT V2 HEMOGLOBIN

(Lamellibrachia
satsuma) 		PF00042
(Globin) 		4 LEU A  70
VAL A 115
TYR A 132
LEU A  31
 HEM  A 200 ( 4.6A)
None
None
None
 0.91A 4b3qA-3wctA:
undetectable		 4b3qA-3wctA:
14.10
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4b0e F1 CAPSULE-ANCHORING
PROTEIN

(Yersinia pestis) 		PF13954
(PapC_N) 		4 LEU A  94
VAL A  38
TYR A  73
LEU A 111
 None
 1.11A 4b3qA-4b0eA:
undetectable		 4b3qA-4b0eA:
14.69
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4bkw ZINC FINGER FYVE
DOMAIN-CONTAINING
PROTEIN 9

(Homo sapiens) 		PF11979
(DUF3480) 		4 LEU A1089
TYR A1053
LEU A1043
TYR A 957
 None
 1.11A 4b3qA-4bkwA:
undetectable		 4b3qA-4bkwA:
21.02
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4d47 LEVANSUCRASE

(Erwinia
amylovora) 		PF02435
(Glyco_hydro_68) 		4 LEU A 276
TYR A   4
LEU A 327
TYR A 331
 None
 1.09A 4b3qA-4d47A:
undetectable		 4b3qA-4d47A:
21.35
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4dad PUTATIVE PILUS
ASSEMBLY-RELATED
PROTEIN

(Burkholderia
pseudomallei) 		PF00072
(Response_reg) 		4 LEU A 112
VAL A   6
TYR A  27
LEU A  80
 None
 1.09A 4b3qA-4dadA:
undetectable		 4b3qA-4dadA:
13.66
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4etp SPINDLE POLE
BODY-ASSOCIATED
PROTEIN VIK1

(Saccharomyces
cerevisiae) 		PF16796
(Microtub_bd) 		4 LEU B 390
VAL B 413
TYR B 408
LEU B 619
 None
 0.92A 4b3qA-4etpB:
undetectable		 4b3qA-4etpB:
20.81
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4fys AMINOPEPTIDASE N

(Homo sapiens) 		PF01433
(Peptidase_M1)
PF11838
(ERAP1_C) 		4 LEU A 622
VAL A 586
TYR A 600
LEU A 561
 None
 1.15A 4b3qA-4fysA:
undetectable		 4b3qA-4fysA:
20.68
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4itm TETRAACYLDISACCHARID
E 4'-KINASE

(Aquifex
aeolicus) 		PF02606
(LpxK) 		4 LEU A  58
VAL A 184
LEU A 306
TYR A  57
 None
 0.89A 4b3qA-4itmA:
undetectable		 4b3qA-4itmA:
20.35
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4iyp IMMUNOGLOBULIN-BINDI
NG PROTEIN 1

(Homo sapiens) 		PF04177
(TAP42) 		4 LEU A  80
VAL A 121
TYR A 193
TYR A 112
 None
 1.02A 4b3qA-4iypA:
undetectable		 4b3qA-4iypA:
17.50
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4jgg ESTERASE TESA

(Pseudomonas
aeruginosa) 		PF13472
(Lipase_GDSL_2) 		4 VAL A  39
TYR A  35
TYR A  37
LEU A  67
 None
 0.95A 4b3qA-4jggA:
undetectable		 4b3qA-4jggA:
17.34
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4jjj CELLULOSE
1,4-BETA-CELLOBIOSID
ASE

(Thermobifida
fusca) 		PF02011
(Glyco_hydro_48) 		4 LEU A 330
TYR A 511
TYR A 430
TYR A 333
 None
None
EDO  A 738 (-4.2A)
None
 1.12A 4b3qA-4jjjA:
undetectable		 4b3qA-4jjjA:
22.07
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4mgg MUCONATE LACTONIZING
ENZYME

(Labrenzia
aggregata) 		PF02746
(MR_MLE_N)
PF13378
(MR_MLE_C) 		4 VAL A  28
TYR A 325
TYR A  20
LEU A  53
 None
 0.89A 4b3qA-4mggA:
undetectable		 4b3qA-4mggA:
21.35
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4n75 OUTER MEMBRANE
PROTEIN ASSEMBLY
FACTOR BAMA

(Escherichia
coli) 		PF01103
(Bac_surface_Ag) 		4 VAL A 532
TYR A 491
TYR A 509
TYR A 649
 None
 1.15A 4b3qA-4n75A:
undetectable		 4b3qA-4n75A:
21.37
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4nqg MITROCOMIN

(Mitrocoma
cellularia) 		PF13202
(EF-hand_5) 		4 LEU A  56
LYS A 126
VAL A 132
LEU A 120
 None
None
None
CZH  A 201 (-4.9A)
 1.00A 4b3qA-4nqgA:
undetectable		 4b3qA-4nqgA:
15.11
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4q38 PUTATIVE
UNCHARACTERIZED
PROTEIN TCP24

(Actinoplanes
teichomyceticus) 		no annotation 4 LEU A  45
VAL A 119
TYR A 113
LEU A 143
 None
 0.90A 4b3qA-4q38A:
undetectable		 4b3qA-4q38A:
20.21
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4r3z ARGININE--TRNA
LIGASE, CYTOPLASMIC

(Homo sapiens) 		PF00750
(tRNA-synt_1d)
PF03485
(Arg_tRNA_synt_N)
PF05746
(DALR_1) 		4 LEU B 224
VAL B 196
TYR B 230
LEU B 592
 None
 1.07A 4b3qA-4r3zB:
undetectable		 4b3qA-4r3zB:
22.95
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4r8l UNCHARACTERIZED
PROTEIN

(Cavia porcellus) 		PF00710
(Asparaginase) 		4 LEU A  13
TYR A  15
LEU A  39
TYR A  74
 None
 1.14A 4b3qA-4r8lA:
undetectable		 4b3qA-4r8lA:
20.39
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4xgc ORIGIN RECOGNITION
COMPLEX SUBUNIT 5

(Drosophila
melanogaster) 		PF13191
(AAA_16)
PF14630
(ORC5_C) 		4 VAL E 221
TYR E 229
TYR E 226
LEU E 203
 None
 1.11A 4b3qA-4xgcE:
undetectable		 4b3qA-4xgcE:
22.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4zaj ARGININE--TRNA
LIGASE, CYTOPLASMIC

(Homo sapiens) 		PF00750
(tRNA-synt_1d)
PF03485
(Arg_tRNA_synt_N)
PF05746
(DALR_1) 		4 LEU A 152
VAL A 124
TYR A 158
LEU A 520
 None
 1.10A 4b3qA-4zajA:
2.0		 4b3qA-4zajA:
22.85
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4zxc HYDROQUINONE
DIOXYGENASE LARGE
SUBUNIT
HYDROQUINONE
DIOXYGENASE SMALL
SUBUNIT

(Pseudomonas sp.
WBC-3) 		no annotation 4 LEU W 326
LYS W 333
LEU A  55
TYR W 327
 None
 1.10A 4b3qA-4zxcW:
undetectable		 4b3qA-4zxcW:
19.09
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5a5t EUKARYOTIC
TRANSLATION
INITIATION FACTOR 3
SUBUNIT H

(Oryctolagus
cuniculus) 		PF01398
(JAB) 		4 LEU H 134
VAL H 149
TYR H 167
LEU H 169
 None
 1.00A 4b3qA-5a5tH:
undetectable		 4b3qA-5a5tH:
19.06
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5aa5 NIFE-HYDROGENASE
LARGE SUBUNIT, HOFG
NIFE-HYDROGENASE
SMALL SUBUNIT, HOFK

(Cupriavidus
necator) 		PF00374
(NiFeSe_Hases)
PF01058
(Oxidored_q6)
PF14720
(NiFe_hyd_SSU_C) 		4 LEU C 187
VAL A  51
LEU A  68
TYR C 183
 None
 0.91A 4b3qA-5aa5C:
undetectable		 4b3qA-5aa5C:
20.88
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5aee ALPHA-GLUCOSIDASE
YIHQ

(Escherichia
coli) 		PF01055
(Glyco_hydro_31) 		4 LEU A 568
VAL A 660
TYR A 662
LEU A 675
 None
 1.13A 4b3qA-5aeeA:
undetectable		 4b3qA-5aeeA:
20.30
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5az0 UNCHARACTERIZED
PROTEIN

(Bombyx mori) 		PF00248
(Aldo_ket_red) 		4 LEU A  58
LYS A  88
VAL A  94
TYR A  66
 None
 1.10A 4b3qA-5az0A:
undetectable		 4b3qA-5az0A:
20.84
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5c77 PROTEIN ARGININE
N-METHYLTRANSFERASE
SFM1

(Saccharomyces
cerevisiae) 		PF04252
(RNA_Me_trans) 		4 LEU A 127
VAL A 103
TYR A 101
TYR A 124
 None
 0.86A 4b3qA-5c77A:
undetectable		 4b3qA-5c77A:
15.30
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ce9 POLYPHENOL OXIDASE

(Juglans regia) 		PF00264
(Tyrosinase)
PF12142
(PPO1_DWL) 		4 LEU A 112
TYR A  90
LEU A 105
TYR A 221
 None
 1.09A 4b3qA-5ce9A:
undetectable		 4b3qA-5ce9A:
19.12
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5dgg UNCHARACTERIZED
PROTEIN

(Legionella
pneumophila) 		no annotation 4 LEU A 224
VAL A 187
LEU A 148
TYR A 220
 None
 1.00A 4b3qA-5dggA:
undetectable		 4b3qA-5dggA:
15.27
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5e8g FRIEND LEUKEMIA
INTEGRATION 1
TRANSCRIPTION FACTOR

(Homo sapiens) 		PF00178
(Ets) 		4 LEU A 339
TYR A 332
LEU A 287
TYR A 342
 None
 1.14A 4b3qA-5e8gA:
undetectable		 4b3qA-5e8gA:
11.07
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5eo6 COPROPORPHYRINOGEN
OXIDASE

(Acinetobacter
baumannii) 		PF01218
(Coprogen_oxidas) 		4 LEU A 219
VAL A  69
LEU A  27
TYR A 218
 None
 1.14A 4b3qA-5eo6A:
undetectable		 4b3qA-5eo6A:
18.90
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5eor ANTI VACCINIA VIRUS
A27 ANTIBODY 8E3
HEAVY CHAIN

(Mus musculus) 		PF07654
(C1-set)
PF07686
(V-set) 		4 LEU H  28
VAL H  35
TYR H 100
LEU H   5
 None
NA  H 301 ( 4.9A)
None
None
 1.14A 4b3qA-5eorH:
undetectable		 4b3qA-5eorH:
16.16
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ffn ENZYME SUBTILASE
SUBTY FROM BACILLUS
SP. TY145

(Bacillus sp.
(in: Bacteria)) 		PF00082
(Peptidase_S8) 		4 VAL A 228
TYR A 287
TYR A 307
LEU A 260
 None
 0.83A 4b3qA-5ffnA:
2.4		 4b3qA-5ffnA:
20.64
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5fnp IRON-SULFUR CLUSTER
REPAIR PROTEIN YTFE

(Escherichia
coli) 		PF01814
(Hemerythrin)
PF04405
(ScdA_N) 		4 LEU A  94
VAL A 101
TYR A 191
LEU A 115
 None
 1.07A 4b3qA-5fnpA:
undetectable		 4b3qA-5fnpA:
17.99
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5i08 SPIKE GLYCOPROTEIN,
ENVELOPE
GLYCOPROTEIN CHIMERA

(Human
coronavirus
HKU1;
Human
immunodeficiency
virus 1) 		PF01601
(Corona_S2)
PF09408
(Spike_rec_bind)
PF16451
(Spike_NTD) 		4 LEU A1141
LYS A1109
VAL A1114
LEU A 861
 None
 1.15A 4b3qA-5i08A:
undetectable		 4b3qA-5i08A:
16.59
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5i8i UREA AMIDOLYASE

(Kluyveromyces
lactis) 		PF00289
(Biotin_carb_N)
PF01425
(Amidase)
PF02626
(CT_A_B)
PF02682
(CT_C_D)
PF02785
(Biotin_carb_C)
PF02786
(CPSase_L_D2) 		4 LEU A1663
LYS A1519
VAL A1695
LEU A1523
 None
 1.03A 4b3qA-5i8iA:
4.5		 4b3qA-5i8iA:
16.13
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5iig VACUOLAR TRANSPORTER
CHAPERONE 4

(Saccharomyces
cerevisiae) 		PF03105
(SPX)
PF09359
(VTC) 		4 LEU A 425
LYS A 428
VAL A 372
LEU A 444
 None
 1.12A 4b3qA-5iigA:
3.2		 4b3qA-5iigA:
23.04
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5jkp UNCHARACTERIZED
PROTEIN

(Pseudomonas
aeruginosa) 		PF08238
(Sel1) 		4 LEU A 224
TYR A 240
LEU A 274
TYR A 250
 None
 1.07A 4b3qA-5jkpA:
undetectable		 4b3qA-5jkpA:
17.67
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5l6f FAD LINKED
OXIDASE-LIKE PROTEIN

(Thermothelomyces
thermophila) 		PF01565
(FAD_binding_4)
PF08031
(BBE) 		4 VAL A 371
TYR A 376
LEU A 429
TYR A 421
 None
BXP  A 509 (-4.2A)
None
None
 1.14A 4b3qA-5l6fA:
undetectable		 4b3qA-5l6fA:
21.92
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5mlv -

(-) 		no annotation 4 LEU G 326
LYS G 351
TYR G 238
LEU G 181
 None
 1.05A 4b3qA-5mlvG:
undetectable		 4b3qA-5mlvG:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ncc FATTY ACID
PHOTODECARBOXYLASE

(Chlorella
variabilis) 		PF00732
(GMC_oxred_N)
PF05199
(GMC_oxred_C) 		4 LEU A 636
LYS A 108
VAL A 110
LEU A  98
 None
 0.98A 4b3qA-5nccA:
2.0		 4b3qA-5nccA:
20.22
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5ovn POL PROTEIN

(Feline
immunodeficiency
virus) 		no annotation 5 LEU A  99
LYS A 102
VAL A 105
LEU A 233
TYR A 317
 None
 0.90A 4b3qA-5ovnA:
26.5		 4b3qA-5ovnA:
55.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5wtk CRISPR-ASSOCIATED
ENDORIBONUCLEASE
C2C2

(Leptotrichia
shahii) 		no annotation 4 LEU A 733
VAL A 777
TYR A 784
TYR A 781
 None
 1.12A 4b3qA-5wtkA:
undetectable		 4b3qA-5wtkA:
17.34
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5xw5 TYROSINE-PROTEIN
PHOSPHATASE CDC14

(Saccharomyces
cerevisiae) 		PF00782
(DSPc)
PF14671
(DSPn) 		4 LEU A 159
LYS A 152
VAL A 148
TYR A 101
 None
 1.14A 4b3qA-5xw5A:
undetectable		 4b3qA-5xw5A:
20.45
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5xya -

(-) 		no annotation 4 LEU A 634
TYR A 691
LEU A 719
TYR A 633
 None
 1.10A 4b3qA-5xyaA:
1.5		 4b3qA-5xyaA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6fwf NITRIC-OXIDE
REDUCTASE

(Neisseria
meningitidis) 		no annotation 4 LEU A 352
LYS A 276
LEU A 374
TYR A 283
 None
 1.16A 4b3qA-6fwfA:
undetectable		 4b3qA-6fwfA:
10.55
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6g1o -

(-) 		no annotation 4 LEU A 449
VAL A 258
TYR A 379
TYR A  99
 None
 1.13A 4b3qA-6g1oA:
1.0		 4b3qA-6g1oA:
undetectable