SIMILAR PATTERNS OF AMINO ACIDS FOR 4AZT_A_SAMA1472_0
List of similar pattern of amino acids derived from ASSAM searchHit | Macromolecule/ Organism |
Pfam | Res. | Interface | HETATM | RMSD | Dali Z-score | Seq. Identity (%) | View | Dock | |
---|---|---|---|---|---|---|---|---|---|---|---|
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 1a2o | CHEB METHYLESTERASE (Salmonellaenterica) |
PF00072(Response_reg)PF01339(CheB_methylest) | 5 | GLY A 166ALA A 170ILE A 102VAL A 310ILE A 135 | None | 1.11A | 4aztA-1a2oA:3.6 | 4aztA-1a2oA:22.85 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 1ebd | DIHYDROLIPOAMIDEDEHYDROGENASE (Geobacillusstearothermophilus) |
PF02852(Pyr_redox_dim)PF07992(Pyr_redox_2) | 5 | GLY A 192ALA A 194ASN A 197ILE A 204ILE A 211 | None | 0.87A | 4aztA-1ebdA:4.1 | 4aztA-1ebdA:22.49 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 1eom | ENDO-BETA-N-ACETYLGLUCOSAMINIDASE F3 (Elizabethkingiameningoseptica) |
PF00704(Glyco_hydro_18) | 5 | ARG A 73GLY A 122ILE A 123VAL A 114ILE A 110 | None | 1.06A | 4aztA-1eomA:undetectable | 4aztA-1eomA:17.75 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 1es6 | MATRIX PROTEIN VP40 (Ebola virus sp.) |
PF07447(VP40) | 5 | ALA A 318ILE A 216LEU A 288VAL A 287ILE A 261 | None | 1.07A | 4aztA-1es6A:undetectable | 4aztA-1es6A:19.08 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 1gpp | ENDONUCLEASE PI-SCEI (Saccharomycescerevisiae) |
PF05203(Hom_end_hint) | 5 | ALA A 11ILE A 434LEU A 445VAL A 8ILE A 18 | None | 1.09A | 4aztA-1gppA:undetectable | 4aztA-1gppA:19.33 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 1hq0 | CYTOTOXICNECROTIZING FACTOR 1 (Escherichiacoli) |
PF05785(CNF1) | 5 | GLY A 842ALA A 840ILE A 843VAL A 833ILE A 858 | None | 1.11A | 4aztA-1hq0A:undetectable | 4aztA-1hq0A:19.28 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 1j6o | TATD-RELATEDDEOXYRIBONUCLEASE (Thermotogamaritima) |
PF01026(TatD_DNase) | 5 | ALA A 183PHE A 153ILE A 172VAL A 188ILE A 196 | None | 1.12A | 4aztA-1j6oA:undetectable | 4aztA-1j6oA:19.86 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 1jy1 | TYROSYL-DNAPHOSPHODIESTERASE (Homo sapiens) |
PF06087(Tyr-DNA_phospho) | 5 | TYR A 302ILE A 188LEU A 268VAL A 278ILE A 296 | None | 1.11A | 4aztA-1jy1A:2.0 | 4aztA-1jy1A:21.55 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 1nzn | FISSION PROTEINFIS1P (Homo sapiens) |
PF14852(Fis1_TPR_N)PF14853(Fis1_TPR_C) | 5 | TYR A 96GLY A 83ALA A 81ILE A 54LEU A 61 | None | 1.10A | 4aztA-1nznA:undetectable | 4aztA-1nznA:14.62 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 1pc2 | MITOCHONDRIA FISSIONPROTEIN (Homo sapiens) |
PF14852(Fis1_TPR_N)PF14853(Fis1_TPR_C) | 5 | TYR A 93GLY A 80ALA A 78ILE A 51LEU A 58 | None | 1.11A | 4aztA-1pc2A:undetectable | 4aztA-1pc2A:14.44 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 1rf5 | 5-ENOLPYRUVYLSHIKIMATE-3-PHOSPHATESYNTHASE (Streptococcuspneumoniae) |
PF00275(EPSP_synthase) | 5 | GLY A 30ALA A 33ILE A 27VAL A 71ILE A 69 | None | 1.07A | 4aztA-1rf5A:undetectable | 4aztA-1rf5A:21.60 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 1suw | PROBABLE INORGANICPOLYPHOSPHATE/ATP-NAD KINASE (Archaeoglobusfulgidus) |
PF01513(NAD_kinase) | 5 | GLY A 67ALA A 79PHE A 232ILE A 65ILE A 43 | None | 1.11A | 4aztA-1suwA:undetectable | 4aztA-1suwA:17.75 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 1tjr | BX1 (Zea mays) |
PF00290(Trp_syntA) | 5 | GLY A 322ALA A 324LEU A 334VAL A 318ILE A 149 | None | 1.13A | 4aztA-1tjrA:undetectable | 4aztA-1tjrA:19.72 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 1v71 | HYPOTHETICAL PROTEINC320.14 INCHROMOSOME III (Schizosaccharomycespombe) |
PF00291(PALP) | 5 | ARG A 316GLY A 284ILE A 307VAL A 280ILE A 278 | NonePLP A 350 ( 4.8A)NoneNoneNone | 1.11A | 4aztA-1v71A:2.7 | 4aztA-1v71A:21.31 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 1z0u | PROBABLE INORGANICPOLYPHOSPHATE/ATP-NAD KINASE (Archaeoglobusfulgidus) |
PF01513(NAD_kinase) | 5 | GLY A 67ALA A 79PHE A 232ILE A 65ILE A 43 | None | 1.06A | 4aztA-1z0uA:undetectable | 4aztA-1z0uA:19.28 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 1z6x | ADP-RIBOSYLATIONFACTOR 4 (Homo sapiens) |
PF00025(Arf) | 5 | GLY A 29ALA A 27ILE A 33VAL A 91ILE A 89 | GDP A 201 (-3.0A)GDP A 201 (-4.1A)NoneNoneNone | 0.89A | 4aztA-1z6xA:undetectable | 4aztA-1z6xA:14.39 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 1z8w | PYRROLIDONE-CARBOXYLATE PEPTIDASE (Pyrococcusfuriosus) |
PF01470(Peptidase_C15) | 6 | ALA A 23ILE A 200GLU A 201LEU A 4VAL A 36ILE A 31 | None | 1.27A | 4aztA-1z8wA:undetectable | 4aztA-1z8wA:17.13 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 1zjk | MANNAN-BINDINGLECTIN SERINEPROTEASE 2 (Homo sapiens) |
PF00084(Sushi)PF00089(Trypsin) | 5 | GLY A 470ALA A 636ILE A 462LEU A 472VAL A 478 | None | 1.12A | 4aztA-1zjkA:undetectable | 4aztA-1zjkA:20.61 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 1zy9 | ALPHA-GALACTOSIDASE (Thermotogamaritima) |
PF02065(Melibiase) | 5 | GLY A 351ALA A 347ILE A 355LEU A 298ILE A 326 | None | 1.02A | 4aztA-1zy9A:undetectable | 4aztA-1zy9A:21.94 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 2aeg | HYPOTHETICAL PROTEINAGR_PAT_140 (Agrobacteriumfabrum) |
PF02586(SRAP) | 5 | ARG A 167GLY A 180PHE A 155ASN A 99LEU A 178 | None | 0.97A | 4aztA-2aegA:undetectable | 4aztA-2aegA:20.84 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 2eax | PEPTIDOGLYCANRECOGNITIONPROTEIN-I-BETA (Homo sapiens) |
PF01510(Amidase_2) | 5 | TYR A 300GLY A 236ALA A 304LEU A 344ILE A 365 | None | 1.09A | 4aztA-2eaxA:undetectable | 4aztA-2eaxA:12.98 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 2eh6 | ACETYLORNITHINEAMINOTRANSFERASE (Aquifexaeolicus) |
PF00202(Aminotran_3) | 6 | TYR A 109GLY A 175ALA A 106ILE A 176VAL A 207ILE A 201 | None | 1.40A | 4aztA-2eh6A:3.1 | 4aztA-2eh6A:19.72 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 2eo5 | 419AA LONGHYPOTHETICALAMINOTRANSFERASE (Sulfurisphaeratokodaii) |
PF00202(Aminotran_3) | 5 | ARG A 296GLY A 215ILE A 132VAL A 124ILE A 121 | None | 1.11A | 4aztA-2eo5A:undetectable | 4aztA-2eo5A:20.98 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 2etv | IRON(III) ABCTRANSPORTER,PERIPLASMICIRON-BINDINGPROTEIN, PUTATIVE (Thermotogamaritima) |
PF01497(Peripla_BP_2) | 5 | ALA A 48ILE A 159LEU A 27VAL A 134ILE A 34 | NoneMLY A 158 (-4.3A)NoneNoneNone | 1.13A | 4aztA-2etvA:undetectable | 4aztA-2etvA:21.24 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 2i7g | MONOOXYGENASE (Agrobacteriumfabrum) |
PF00296(Bac_luciferase) | 5 | GLY A 316ASN A 12ARG A 52VAL A 257ILE A 261 | None | 0.94A | 4aztA-2i7gA:undetectable | 4aztA-2i7gA:22.90 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 2iny | HEXON PROTEIN (Fowlaviadenovirus A) |
PF01065(Adeno_hexon)PF03678(Adeno_hexon_C) | 5 | TYR A 682GLY A 679ASN A 858LEU A 652ILE A 297 | None | 1.08A | 4aztA-2inyA:undetectable | 4aztA-2inyA:21.05 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 2ipx | RRNA2'-O-METHYLTRANSFERASE FIBRILLARIN (Homo sapiens) |
PF01269(Fibrillarin) | 5 | GLY A 168ALA A 170PHE A 193VAL A 238ILE A 246 | MTA A4001 (-3.3A)MTA A4001 (-3.6A)MTA A4001 (-3.5A)MTA A4001 (-4.1A)None | 1.07A | 4aztA-2ipxA:10.2 | 4aztA-2ipxA:18.87 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 2oqh | PUTATIVE ISOMERASE (Streptomycescoelicolor) |
PF02746(MR_MLE_N)PF13378(MR_MLE_C) | 5 | ARG A 61ASN A 14ILE A 334VAL A 35ILE A 304 | None | 0.98A | 4aztA-2oqhA:2.6 | 4aztA-2oqhA:20.45 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 2pvz | PRPF METHYLACONITATEISOMERASE (Shewanellaoneidensis) |
PF04303(PrpF) | 5 | GLY A 115ALA A 113ILE A 119VAL A 152ILE A 154 | None | 1.12A | 4aztA-2pvzA:undetectable | 4aztA-2pvzA:22.11 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 2r4g | TELOMERASE REVERSETRANSCRIPTASE (Tetrahymenathermophila) |
PF12009(Telomerase_RBD) | 6 | GLY A 457ASN A 297ILE A 460LEU A 420VAL A 419ILE A 464 | None | 1.43A | 4aztA-2r4gA:undetectable | 4aztA-2r4gA:18.69 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 2xa7 | ADAPTOR-RELATEDPROTEIN COMPLEX 2,ALPHA 2 SUBUNIT (Rattusnorvegicus) |
PF01602(Adaptin_N) | 5 | ALA A 79ASN A 81ILE A 112LEU A 101ILE A 109 | None | 0.96A | 4aztA-2xa7A:undetectable | 4aztA-2xa7A:23.21 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 2xfg | ENDOGLUCANASE 1 (Ruminiclostridiumthermocellum) |
PF00759(Glyco_hydro_9) | 5 | TYR A 69GLY A 75ALA A 72ILE A 94ILE A 14 | None | 0.89A | 4aztA-2xfgA:undetectable | 4aztA-2xfgA:22.28 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 2z8z | LIPASE (Pseudomonas sp.MIS38) |
PF00353(HemolysinCabind) | 5 | GLY A 321ALA A 317ILE A 325VAL A 342ILE A 340 | None | 0.82A | 4aztA-2z8zA:undetectable | 4aztA-2z8zA:22.42 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3aib | GLUCOSYLTRANSFERASE-SI (Streptococcusmutans) |
PF02324(Glyco_hydro_70) | 5 | ALA A 435ASN A 436ILE A1053GLU A 375LEU A 382 | None | 1.11A | 4aztA-3aibA:2.8 | 4aztA-3aibA:20.56 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3aq4 | ADP-RIBOSYLATIONFACTOR 1 (Arabidopsisthaliana) |
PF00025(Arf) | 5 | GLY A 29ALA A 27ILE A 33VAL A 91ILE A 89 | GDP A 183 (-3.3A)GDP A 183 (-4.3A)NoneNoneNone | 0.89A | 4aztA-3aq4A:undetectable | 4aztA-3aq4A:15.04 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3co8 | ALANINE RACEMASE (Oenococcus oeni) |
PF00842(Ala_racemase_C)PF01168(Ala_racemase_N) | 5 | GLY A 70ALA A 72ILE A 84LEU A 62VAL A 64 | None | 1.13A | 4aztA-3co8A:undetectable | 4aztA-3co8A:21.47 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3db7 | PUTATIVECALCIUM-REGULATEDPERIPLASMIC PROTEIN (Bacteroidesthetaiotaomicron) |
PF11396(PepSY_like) | 5 | PHE A 43ASN A 68ILE A 39LEU A 50VAL A 64 | NoneNoneNoneEDO A 4 ( 4.8A)None | 1.13A | 4aztA-3db7A:undetectable | 4aztA-3db7A:12.52 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3do6 | FORMATE--TETRAHYDROFOLATE LIGASE (Thermotogamaritima) |
PF01268(FTHFS) | 5 | ALA A 456ILE A 434GLU A 435LEU A 511VAL A 496 | EDO A 544 ( 4.0A)NoneNoneNoneNone | 0.96A | 4aztA-3do6A:undetectable | 4aztA-3do6A:22.39 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3fwz | INNER MEMBRANEPROTEIN YBAL (Escherichiacoli) |
PF02254(TrkA_N) | 5 | ALA A 477ILE A 498GLU A 494VAL A 423ILE A 489 | NoneNoneAMP A 601 (-3.6A)AMP A 601 ( 4.9A)AMP A 601 (-3.6A) | 1.13A | 4aztA-3fwzA:6.0 | 4aztA-3fwzA:14.54 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3htx | HEN1 (Arabidopsisthaliana) |
PF13847(Methyltransf_31) | 5 | ARG A 701GLY A 721ILE A 779LEU A 795VAL A 797 | G B 22 (-3.9A)SAH A 951 (-4.3A)SAH A 951 (-3.9A)SAH A 951 (-3.9A)SAH A 951 (-3.9A) | 0.85A | 4aztA-3htxA:11.9 | 4aztA-3htxA:20.27 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3ibg | ATPASE, SUBUNIT OFTHE GET COMPLEX (Aspergillusfumigatus) |
PF02374(ArsA_ATPase) | 5 | ALA A 51ASN A 88ILE A 155LEU A 46ILE A 60 | None | 1.04A | 4aztA-3ibgA:undetectable | 4aztA-3ibgA:20.69 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3l6u | ABC-TYPE SUGARTRANSPORT SYSTEMPERIPLASMICCOMPONENT (Exiguobacteriumsibiricum) |
PF13407(Peripla_BP_4) | 5 | GLY A 12ALA A 41ILE A 68VAL A 65ILE A 90 | None | 1.11A | 4aztA-3l6uA:2.6 | 4aztA-3l6uA:19.65 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3lrp | ADP-RIBOSYLATIONFACTOR 1 (Plasmodiumfalciparum) |
PF00025(Arf) | 5 | GLY A 29ALA A 27ILE A 33VAL A 91ILE A 89 | GDP A 182 (-3.1A)GDP A 182 (-4.3A)NoneNoneNone | 0.94A | 4aztA-3lrpA:2.4 | 4aztA-3lrpA:14.52 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3lvr | ARF-GAP WITH SH3DOMAIN, ANK REPEATAND PHDOMAIN-CONTAININGPROTEIN 3,ADP-RIBOSYLATIONFACTOR 6 (Homo sapiens;syntheticconstruct) |
PF00025(Arf)PF01412(ArfGap)PF12796(Ank_2) | 5 | GLY E 25ALA E 23ILE E 29VAL E 87ILE E 85 | GDP E 737 (-3.2A)GDP E 737 ( 4.4A)NoneNoneNone | 0.86A | 4aztA-3lvrE:2.5 | 4aztA-3lvrE:23.13 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3m1r | FORMIMIDOYLGLUTAMASE (Bacillussubtilis) |
PF00491(Arginase) | 6 | GLY A 124ALA A 54ILE A 122LEU A 44VAL A 42ILE A 40 | None | 1.36A | 4aztA-3m1rA:undetectable | 4aztA-3m1rA:21.39 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3mes | CHOLINE KINASE (Cryptosporidiumparvum) |
PF01633(Choline_kinase) | 5 | GLY A 372ALA A 395ASN A 396ILE A 369ILE A 232 | None | 1.13A | 4aztA-3mesA:7.3 | 4aztA-3mesA:22.26 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3n11 | CHITINASE A (Bacillus cereus) |
PF00704(Glyco_hydro_18) | 5 | GLY A 67ASN A 42ILE A 106VAL A 76ILE A 128 | None | 1.00A | 4aztA-3n11A:undetectable | 4aztA-3n11A:19.00 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3nd6 | PHOSPHOPANTETHEINEADENYLYLTRANSFERASE (Enterococcusfaecalis) |
PF01467(CTP_transf_like) | 5 | ALA A 26ASN A 64ILE A 34LEU A 21ILE A 55 | NoneNoneNoneATP A 961 (-4.4A)None | 1.14A | 4aztA-3nd6A:3.3 | 4aztA-3nd6A:15.56 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3nva | CTP SYNTHASE (Sulfolobussolfataricus) |
PF00117(GATase)PF06418(CTP_synth_N) | 5 | ALA A 136ILE A 127LEU A 140VAL A 39ILE A 90 | None | 0.98A | 4aztA-3nvaA:undetectable | 4aztA-3nvaA:23.31 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3o47 | ADP-RIBOSYLATIONFACTORGTPASE-ACTIVATINGPROTEIN 1,ADP-RIBOSYLATIONFACTOR 1 (Homo sapiens) |
PF00025(Arf)PF01412(ArfGap) | 5 | GLY A 159ALA A 157ILE A 163VAL A 221ILE A 219 | GDP A 502 (-3.2A)GDP A 502 (-4.4A)NoneNoneNone | 0.85A | 4aztA-3o47A:undetectable | 4aztA-3o47A:21.95 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3p8c | NCK-ASSOCIATEDPROTEIN 1 (Homo sapiens) |
PF09735(Nckap1) | 5 | TYR B 545ALA B 548ILE B 409GLU B 413LEU B 385 | None | 1.12A | 4aztA-3p8cB:undetectable | 4aztA-3p8cB:18.37 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3pbp | NUCLEOPORINNUP116/NSP116 (Saccharomycescerevisiae) |
PF04096(Nucleoporin2) | 5 | GLY B1020ASN B 967ILE B1024VAL B 995ILE B1003 | None | 0.96A | 4aztA-3pbpB:undetectable | 4aztA-3pbpB:13.90 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3r38 | UDP-N-ACETYLGLUCOSAMINE1-CARBOXYVINYLTRANSFERASE 1 (Listeriamonocytogenes) |
PF00275(EPSP_synthase) | 5 | GLY A 380ALA A 383ILE A 377VAL A 6ILE A 4 | None | 0.95A | 4aztA-3r38A:undetectable | 4aztA-3r38A:24.87 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3rza | TRIPEPTIDASE (Staphylococcusaureus) |
PF01546(Peptidase_M20)PF07687(M20_dimer) | 6 | GLY A 114ALA A 117PHE A 11GLU A 351LEU A 339VAL A 341 | None | 1.46A | 4aztA-3rzaA:undetectable | 4aztA-3rzaA:20.73 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3u02 | PUTATIVETRANSCRIPTION-ASSOCIATED PROTEIN TFIIS (Pyrococcusfuriosus) |
PF08489(DUF1743) | 5 | TYR A 79PHE A 97ILE A 3VAL A 72ILE A 69 | None | 0.91A | 4aztA-3u02A:undetectable | 4aztA-3u02A:19.57 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3vvd | AMINO ACID ABCTRANSPORTER, BINDINGPROTEIN (Thermusthermophilus) |
PF00497(SBP_bac_3) | 5 | GLY A 17ALA A 77ASN A 26ILE A 56LEU A 67 | None | 1.05A | 4aztA-3vvdA:undetectable | 4aztA-3vvdA:19.27 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3wyz | RIBONUCLEASE PPROTEIN COMPONENT 3 (Thermococcuskodakarensis) |
PF01876(RNase_P_p30) | 5 | ARG A 19GLY A 93ILE A 98VAL A 91ILE A 77 | GOL A 301 (-2.9A)NoneNoneNoneNone | 1.04A | 4aztA-3wyzA:undetectable | 4aztA-3wyzA:17.07 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4ayg | GLUCANSUCRASE (Lactobacillusreuteri) |
PF01473(CW_binding_1)PF02324(Glyco_hydro_70) | 5 | ALA A 983ASN A 984ILE A1601GLU A 931LEU A 940 | None | 1.09A | 4aztA-4aygA:2.5 | 4aztA-4aygA:20.90 | ||
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target. | 4azv | WBDD (Escherichiacoli) |
PF00069(Pkinase)PF13847(Methyltransf_31) | 7 | GLY A 61ARG A 109ILE A 110GLU A 111LEU A 128VAL A 130ILE A 134 | SAM A1474 (-3.2A)SAM A1474 (-4.8A)SAM A1474 (-3.8A)SAM A1474 (-2.5A)SAM A1474 (-4.3A)SAM A1474 ( 3.4A)SAM A1474 ( 4.8A) | 1.06A | 4aztA-4azvA:55.9 | 4aztA-4azvA:100.00 | ||
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target. | 4azv | WBDD (Escherichiacoli) |
PF00069(Pkinase)PF13847(Methyltransf_31) | 11 | TYR A 16ARG A 36GLY A 61ALA A 63PHE A 83ASN A 87ILE A 110GLU A 111LEU A 128VAL A 130ILE A 134 | SAM A1474 (-3.5A)SAM A1474 ( 3.1A)SAM A1474 (-3.2A)SAM A1474 (-3.0A)SAM A1474 (-3.6A)SAM A1474 (-3.7A)SAM A1474 (-3.8A)SAM A1474 (-2.5A)SAM A1474 (-4.3A)SAM A1474 ( 3.4A)SAM A1474 ( 4.8A) | 0.10A | 4aztA-4azvA:55.9 | 4aztA-4azvA:100.00 | ||
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target. | 4azw | WBDD (Escherichiacoli) |
PF00069(Pkinase)PF13847(Methyltransf_31) | 9 | ARG A 31GLY A 61PHE A 83ASN A 87ARG A 109ILE A 110GLU A 111VAL A 130ILE A 134 | SAM A1451 ( 4.9A)SAM A1451 (-3.6A)SAM A1451 (-3.5A)SAM A1451 (-4.0A)SAM A1451 (-3.9A)SAM A1451 (-4.0A)SAM A1451 (-3.1A)SAM A1451 (-4.6A)None | 1.21A | 4aztA-4azwA:49.9 | 4aztA-4azwA:99.36 | ||
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target. | 4azw | WBDD (Escherichiacoli) |
PF00069(Pkinase)PF13847(Methyltransf_31) | 12 | TYR A 16ARG A 36GLY A 61ALA A 63PHE A 83ASN A 87ARG A 109ILE A 110GLU A 111LEU A 128VAL A 130ILE A 134 | SAM A1451 (-3.6A)SAM A1451 (-3.2A)SAM A1451 (-3.6A)SAM A1451 (-3.7A)SAM A1451 (-3.5A)SAM A1451 (-4.0A)SAM A1451 (-3.9A)SAM A1451 (-4.0A)SAM A1451 (-3.1A)SAM A1451 (-4.1A)SAM A1451 (-4.6A)None | 0.40A | 4aztA-4azwA:49.9 | 4aztA-4azwA:99.36 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4b3i | FATTY ACIDBETA-OXIDATIONCOMPLEX ALPHA-CHAINFADB (Mycobacteriumtuberculosis) |
PF00378(ECH_1)PF00725(3HCDH)PF02737(3HCDH_N) | 5 | ALA A 662PHE A 672ASN A 663ILE A 670VAL A 514 | None | 1.06A | 4aztA-4b3iA:4.2 | 4aztA-4b3iA:23.47 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4bc5 | XYLULOSE KINASE (Homo sapiens) |
PF00370(FGGY_N)PF02782(FGGY_C) | 5 | GLY A 414ALA A 418ARG A 391GLU A 407ILE A 346 | None | 1.04A | 4aztA-4bc5A:undetectable | 4aztA-4bc5A:23.44 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4c30 | DNA HELICASE II (Deinococcusradiodurans) |
PF00580(UvrD-helicase)PF13361(UvrD_C) | 5 | GLY A 337ALA A 335ILE A 370VAL A 340ILE A 359 | None | 1.11A | 4aztA-4c30A:3.9 | 4aztA-4c30A:24.13 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4dg5 | PHOSPHOGLYCERATEKINASE (Staphylococcusaureus) |
PF00162(PGK) | 5 | ALA A 78ILE A 44LEU A 113VAL A 112ILE A 48 | None | 1.04A | 4aztA-4dg5A:4.2 | 4aztA-4dg5A:23.09 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4fme | ADP-RIBOSYLATIONFACTOR 6 (Homo sapiens) |
PF00025(Arf) | 5 | GLY C 25ALA C 23ILE C 29VAL C 87ILE C 85 | GTP C 201 (-3.0A)GTP C 201 (-4.5A)NoneNoneNone | 0.91A | 4aztA-4fmeC:undetectable | 4aztA-4fmeC:14.47 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4ikv | DI-TRIPEPTIDE ABCTRANSPORTER(PERMEASE) (Geobacilluskaustophilus) |
PF00854(PTR2) | 5 | GLY A 101ALA A 97ASN A 138ILE A 105ILE A 128 | None | 1.08A | 4aztA-4ikvA:undetectable | 4aztA-4ikvA:20.93 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4oja | SUPEROXIDE DISMUTASE[CU-ZN] (Hydra vulgaris) |
PF00080(Sod_Cu) | 5 | GLY A 43ALA A 139ASN A 121ILE A 86ILE A 33 | None | 1.03A | 4aztA-4ojaA:undetectable | 4aztA-4ojaA:14.41 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4qww | ACETYLCHOLINESTERASE (Bungarusfasciatus) |
PF00135(COesterase) | 5 | TYR A 375ARG A 517ALA A 390VAL A 395ILE A 287 | None | 1.11A | 4aztA-4qwwA:undetectable | 4aztA-4qwwA:21.58 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4ru4 | TAIL SPIKE PROTEINGP49 (Pseudomonasvirus LKA1) |
PF13229(Beta_helix) | 5 | GLY A 389ASN A 409ILE A 380LEU A 391ILE A 267 | None | 1.13A | 4aztA-4ru4A:undetectable | 4aztA-4ru4A:22.54 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4w4t | MXAA (Stigmatellaaurantiaca) |
PF07993(NAD_binding_4) | 5 | GLY A1262ALA A1258ASN A1259ILE A1266ILE A1239 | None | 1.13A | 4aztA-4w4tA:undetectable | 4aztA-4w4tA:23.31 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4x1z | VP1 (Rabbithemorrhagicdisease virus) |
PF00915(Calici_coat) | 5 | GLY A 486ALA A 464ARG A 469ILE A 426ILE A 434 | None | 1.12A | 4aztA-4x1zA:undetectable | 4aztA-4x1zA:20.69 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4xk8 | PUTATIVEUNCHARACTERIZEDPROTEIN (Pisum sativum) |
PF02605(PsaL) | 5 | GLY L 85ALA L 83ILE L 144LEU L 60VAL L 147 | NoneBCR L 201 ( 3.9A)NoneNoneNone | 0.89A | 4aztA-4xk8L:undetectable | 4aztA-4xk8L:14.79 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4xni | DI-OR TRIPEPTIDE:H+SYMPORTER (Streptococcusthermophilus) |
PF00854(PTR2) | 5 | GLY A 91ALA A 87ASN A 128ILE A 95ILE A 118 | None | 0.99A | 4aztA-4xniA:undetectable | 4aztA-4xniA:22.46 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4ylg | ADP-RIBOSYLATIONFACTOR (Entamoebahistolytica) |
PF00025(Arf) | 5 | GLY A 25ALA A 23ILE A 29VAL A 87ILE A 85 | GDP A 201 (-3.3A)GDP A 201 (-4.2A)NoneNoneNone | 0.88A | 4aztA-4ylgA:undetectable | 4aztA-4ylgA:15.28 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 5b48 | 2-OXOACID--FERREDOXIN OXIDOREDUCTASEALPHA SUBUNIT (Sulfurisphaeratokodaii) |
PF01558(POR)PF01855(POR_N) | 5 | ARG A 455ALA A 304ILE A 298VAL A 337ILE A 339 | None | 1.03A | 4aztA-5b48A:3.2 | 4aztA-5b48A:21.86 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 5b5z | PTLCIB4 H88A MUTANT (Phaeodactylumtricornutum) |
no annotation | 5 | GLY A 112ALA A 124LEU A 196VAL A 103ILE A 233 | None | 1.03A | 4aztA-5b5zA:3.0 | 4aztA-5b5zA:18.50 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 5d8h | 50S RIBOSOMALPROTEIN L11 (Methanocaldococcusjannaschii) |
PF00298(Ribosomal_L11)PF03946(Ribosomal_L11_N) | 5 | ILE C 38GLU C 37LEU C 8VAL C 52ILE C 65 | NoneNone U A1171 ( 4.4A)NoneNone | 1.10A | 4aztA-5d8hC:undetectable | 4aztA-5d8hC:11.93 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 5efv | PHI ETA ORF 56-LIKEPROTEIN (Staphylococcusvirus 11) |
no annotation | 5 | GLY A 405ALA A 386ILE A 418LEU A 389ILE A 176 | None | 1.09A | 4aztA-5efvA:undetectable | 4aztA-5efvA:21.50 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 5eoe | BETA-LACTAMASE (Pseudomonasaeruginosa) |
PF13354(Beta-lactamase2) | 6 | GLY A 51ILE A 26GLU A 30LEU A 41VAL A 39ILE A 37 | None | 1.03A | 4aztA-5eoeA:undetectable | 4aztA-5eoeA:19.37 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 5hxb | EUKARYOTIC PEPTIDECHAIN RELEASE FACTORGTP-BINDING SUBUNITERF3A (Homo sapiens) |
no annotation | 5 | GLY X 627ALA X 533ILE X 626LEU X 552ILE X 538 | 85C Z 502 (-3.8A)None85C Z 502 (-3.9A)NoneNone | 1.13A | 4aztA-5hxbX:undetectable | 4aztA-5hxbX:14.94 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 5ijl | DNA POLYMERASE IILARGE SUBUNIT (Pyrococcusabyssi) |
PF03833(PolC_DP2) | 5 | GLY A 49ALA A 44ILE A 64VAL A 51ILE A 109 | None | 1.01A | 4aztA-5ijlA:undetectable | 4aztA-5ijlA:20.26 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 5ipw | OLIGOPEPTIDE ABCTRANSPORTER,PERIPLASMICOLIGOPEPTIDE-BINDINGPROTEIN, PUTATIVE (Thermotogamaritima) |
PF00496(SBP_bac_5) | 5 | GLY A 362ALA A 414LEU A 416VAL A 417ILE A 358 | None | 1.14A | 4aztA-5ipwA:undetectable | 4aztA-5ipwA:21.85 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 5ir6 | BD-TYPE QUINOLOXIDASE SUBUNIT I (Geobacillusstearothermophilus) |
PF01654(Cyt_bd_oxida_I) | 5 | TYR A 389ALA A 90GLU A 101VAL A 149ILE A 146 | NoneNoneHEB A 502 (-3.0A)HDD A 503 ( 4.9A)HDD A 503 ( 2.9A) | 1.14A | 4aztA-5ir6A:undetectable | 4aztA-5ir6A:22.78 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 5kzd | N-ACETYLNEURAMINATELYASE (Staphylococcusaureus) |
PF00701(DHDPS) | 5 | GLY A 82ASN A 46ILE A 126LEU A 84ILE A 90 | None | 1.06A | 4aztA-5kzdA:undetectable | 4aztA-5kzdA:19.93 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 5lj6 | MACROLIDE EXPORTATP-BINDING/PERMEASEPROTEIN MACB (Aggregatibacteractinomycetemcomitans) |
no annotation | 5 | GLY A 579ALA A 582ILE A 575LEU A 273ILE A 261 | None | 1.09A | 4aztA-5lj6A:undetectable | 4aztA-5lj6A:23.17 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 5msy | GLYCOSIDE HYDROLASE (Bacteroidesthetaiotaomicron) |
PF12904(Collagen_bind_2)PF13204(DUF4038) | 5 | TYR A 112GLY A 167ALA A 165ILE A 204ILE A 184 | None | 1.03A | 4aztA-5msyA:undetectable | 4aztA-5msyA:20.95 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 5ng6 | CRISPR-ASSOCIATEDENDONUCLEASE CPF1 (Francisellatularensis) |
no annotation | 5 | GLY A1263ALA A1259ILE A 913VAL A1004ILE A1002 | None | 1.08A | 4aztA-5ng6A:undetectable | 4aztA-5ng6A:17.02 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 5nks | DIHYDROPYRIMIDINASE-RELATED PROTEIN 4 (Homo sapiens) |
no annotation | 5 | GLY A 450ILE A 447LEU A 41VAL A 37ILE A 19 | GLY A 450 ( 0.0A)ILE A 447 ( 0.6A)LEU A 41 ( 0.5A)VAL A 37 ( 0.6A)ILE A 19 ( 0.7A) | 0.88A | 4aztA-5nksA:undetectable | 4aztA-5nksA:22.46 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 5uf8 | POTENTIALADP-RIBOSYLATIONFACTOR (Candidaalbicans) |
PF00025(Arf) | 5 | GLY A 29ALA A 27ILE A 33VAL A 91ILE A 89 | GDP A 500 (-3.2A)GDP A 500 (-4.2A)NoneNoneNone | 0.85A | 4aztA-5uf8A:undetectable | 4aztA-5uf8A:15.21 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 5uow | N-METHYL-D-ASPARTATERECEPTOR SUBUNITNR1-8A (Xenopus laevis) |
PF00060(Lig_chan)PF01094(ANF_receptor)PF10613(Lig_chan-Glu_bd) | 5 | GLY A 30ALA A 62ILE A 90VAL A 87ILE A 116 | None | 1.12A | 4aztA-5uowA:undetectable | 4aztA-5uowA:20.27 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 5wh8 | PUTATIVECARBOHYDRATE-ACTIVEENZYME (unculturedorganism) |
no annotation | 5 | GLY A 80PHE A 110ILE A 109VAL A 316ILE A 152 | None | 1.12A | 4aztA-5wh8A:undetectable | 4aztA-5wh8A:undetectable | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 5wi5 | UDP-N-ACETYLGLUCOSAMINE1-CARBOXYVINYLTRANSFERASE 1 (Streptococcuspneumoniae) |
PF00275(EPSP_synthase) | 5 | GLY A 384ALA A 387ILE A 381VAL A 6ILE A 4 | None | 0.99A | 4aztA-5wi5A:undetectable | 4aztA-5wi5A:22.57 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 5ys9 | ACYL-COENZYME AOXIDASE 3 (Yarrowialipolytica) |
no annotation | 5 | GLY A 203ALA A 208ILE A 259VAL A 124ILE A 120 | None | 1.11A | 4aztA-5ys9A:undetectable | 4aztA-5ys9A:undetectable | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 5zqj | BETA-XYLOSIDASE (Bacilluspumilus) |
no annotation | 5 | ALA A 406PHE A 398ILE A 452VAL A 459ILE A 456 | None | 1.06A | 4aztA-5zqjA:undetectable | 4aztA-5zqjA:undetectable | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 6bbp | CYTOHESIN-3,ADP-RIBOSYLATION FACTOR 6 (Homo sapiens;Mus musculus) |
no annotation | 5 | GLY A 423ALA A 421ILE A 427VAL A 485ILE A 483 | GTP A 601 (-3.3A)GTP A 601 (-4.2A)NoneNoneNone | 0.83A | 4aztA-6bbpA:undetectable | 4aztA-6bbpA:undetectable | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 6esq | HYDROXYMETHYLGLUTARYL-COA SYNTHASE (Methanothermococcusthermolithotrophicus) |
no annotation | 6 | GLY I 279ALA I 275ILE I 283LEU I 263VAL I 236ILE I 293 | None | 1.29A | 4aztA-6esqI:undetectable | 4aztA-6esqI:undetectable | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 6exs | PEPTIDE ABCTRANSPORTER PERMEASE (Staphylococcushominis) |
no annotation | 5 | GLY A 102ALA A 98ASN A 139ILE A 106ILE A 129 | None | 0.96A | 4aztA-6exsA:undetectable | 4aztA-6exsA:undetectable | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 6fae | ADP-RIBOSYLATIONFACTOR 1 (Homo sapiens) |
no annotation | 5 | GLY B 29ALA B 27ILE B 33VAL B 91ILE B 89 | None | 0.85A | 4aztA-6faeB:undetectable | 4aztA-6faeB:undetectable |