SIMILAR PATTERNS OF AMINO ACIDS FOR 4AZT_A_SAMA1472_0

List of similar pattern of amino acids derived from ASSAM search

Hit pattern: 3D amino acid arrangements similar to known drug binding site

Query pattern: Residues from known binding site for annotated drug that match the hit pattern


(Click link on the last column to view superposed patterns of amino acids in NGL viewer)
(Note that only 3-12 residue patterns can be used for ASSAM searches)
Filter list by:
Hit Macromolecule/
Organism
Pfam Res. Interface HETATM RMSD Dali Z-score Seq. Identity (%) View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1a2o CHEB METHYLESTERASE

(Salmonella
enterica)
PF00072
(Response_reg)
PF01339
(CheB_methylest)
5 GLY A 166
ALA A 170
ILE A 102
VAL A 310
ILE A 135
None
1.11A 4aztA-1a2oA:
3.6
4aztA-1a2oA:
22.85
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ebd DIHYDROLIPOAMIDE
DEHYDROGENASE


(Geobacillus
stearothermophilus)
PF02852
(Pyr_redox_dim)
PF07992
(Pyr_redox_2)
5 GLY A 192
ALA A 194
ASN A 197
ILE A 204
ILE A 211
None
0.87A 4aztA-1ebdA:
4.1
4aztA-1ebdA:
22.49
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1eom ENDO-BETA-N-ACETYLGL
UCOSAMINIDASE F3


(Elizabethkingia
meningoseptica)
PF00704
(Glyco_hydro_18)
5 ARG A  73
GLY A 122
ILE A 123
VAL A 114
ILE A 110
None
1.06A 4aztA-1eomA:
undetectable
4aztA-1eomA:
17.75
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1es6 MATRIX PROTEIN VP40

(Ebola virus sp.)
PF07447
(VP40)
5 ALA A 318
ILE A 216
LEU A 288
VAL A 287
ILE A 261
None
1.07A 4aztA-1es6A:
undetectable
4aztA-1es6A:
19.08
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1gpp ENDONUCLEASE PI-SCEI

(Saccharomyces
cerevisiae)
PF05203
(Hom_end_hint)
5 ALA A  11
ILE A 434
LEU A 445
VAL A   8
ILE A  18
None
1.09A 4aztA-1gppA:
undetectable
4aztA-1gppA:
19.33
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1hq0 CYTOTOXIC
NECROTIZING FACTOR 1


(Escherichia
coli)
PF05785
(CNF1)
5 GLY A 842
ALA A 840
ILE A 843
VAL A 833
ILE A 858
None
1.11A 4aztA-1hq0A:
undetectable
4aztA-1hq0A:
19.28
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1j6o TATD-RELATED
DEOXYRIBONUCLEASE


(Thermotoga
maritima)
PF01026
(TatD_DNase)
5 ALA A 183
PHE A 153
ILE A 172
VAL A 188
ILE A 196
None
1.12A 4aztA-1j6oA:
undetectable
4aztA-1j6oA:
19.86
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1jy1 TYROSYL-DNA
PHOSPHODIESTERASE


(Homo sapiens)
PF06087
(Tyr-DNA_phospho)
5 TYR A 302
ILE A 188
LEU A 268
VAL A 278
ILE A 296
None
1.11A 4aztA-1jy1A:
2.0
4aztA-1jy1A:
21.55
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1nzn FISSION PROTEIN
FIS1P


(Homo sapiens)
PF14852
(Fis1_TPR_N)
PF14853
(Fis1_TPR_C)
5 TYR A  96
GLY A  83
ALA A  81
ILE A  54
LEU A  61
None
1.10A 4aztA-1nznA:
undetectable
4aztA-1nznA:
14.62
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1pc2 MITOCHONDRIA FISSION
PROTEIN


(Homo sapiens)
PF14852
(Fis1_TPR_N)
PF14853
(Fis1_TPR_C)
5 TYR A  93
GLY A  80
ALA A  78
ILE A  51
LEU A  58
None
1.11A 4aztA-1pc2A:
undetectable
4aztA-1pc2A:
14.44
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1rf5 5-ENOLPYRUVYLSHIKIMA
TE-3-PHOSPHATE
SYNTHASE


(Streptococcus
pneumoniae)
PF00275
(EPSP_synthase)
5 GLY A  30
ALA A  33
ILE A  27
VAL A  71
ILE A  69
None
1.07A 4aztA-1rf5A:
undetectable
4aztA-1rf5A:
21.60
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1suw PROBABLE INORGANIC
POLYPHOSPHATE/ATP-NA
D KINASE


(Archaeoglobus
fulgidus)
PF01513
(NAD_kinase)
5 GLY A  67
ALA A  79
PHE A 232
ILE A  65
ILE A  43
None
1.11A 4aztA-1suwA:
undetectable
4aztA-1suwA:
17.75
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1tjr BX1

(Zea mays)
PF00290
(Trp_syntA)
5 GLY A 322
ALA A 324
LEU A 334
VAL A 318
ILE A 149
None
1.13A 4aztA-1tjrA:
undetectable
4aztA-1tjrA:
19.72
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1v71 HYPOTHETICAL PROTEIN
C320.14 IN
CHROMOSOME III


(Schizosaccharomyces
pombe)
PF00291
(PALP)
5 ARG A 316
GLY A 284
ILE A 307
VAL A 280
ILE A 278
None
PLP  A 350 ( 4.8A)
None
None
None
1.11A 4aztA-1v71A:
2.7
4aztA-1v71A:
21.31
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1z0u PROBABLE INORGANIC
POLYPHOSPHATE/ATP-NA
D KINASE


(Archaeoglobus
fulgidus)
PF01513
(NAD_kinase)
5 GLY A  67
ALA A  79
PHE A 232
ILE A  65
ILE A  43
None
1.06A 4aztA-1z0uA:
undetectable
4aztA-1z0uA:
19.28
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1z6x ADP-RIBOSYLATION
FACTOR 4


(Homo sapiens)
PF00025
(Arf)
5 GLY A  29
ALA A  27
ILE A  33
VAL A  91
ILE A  89
GDP  A 201 (-3.0A)
GDP  A 201 (-4.1A)
None
None
None
0.89A 4aztA-1z6xA:
undetectable
4aztA-1z6xA:
14.39
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1z8w PYRROLIDONE-CARBOXYL
ATE PEPTIDASE


(Pyrococcus
furiosus)
PF01470
(Peptidase_C15)
6 ALA A  23
ILE A 200
GLU A 201
LEU A   4
VAL A  36
ILE A  31
None
1.27A 4aztA-1z8wA:
undetectable
4aztA-1z8wA:
17.13
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1zjk MANNAN-BINDING
LECTIN SERINE
PROTEASE 2


(Homo sapiens)
PF00084
(Sushi)
PF00089
(Trypsin)
5 GLY A 470
ALA A 636
ILE A 462
LEU A 472
VAL A 478
None
1.12A 4aztA-1zjkA:
undetectable
4aztA-1zjkA:
20.61
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1zy9 ALPHA-GALACTOSIDASE

(Thermotoga
maritima)
PF02065
(Melibiase)
5 GLY A 351
ALA A 347
ILE A 355
LEU A 298
ILE A 326
None
1.02A 4aztA-1zy9A:
undetectable
4aztA-1zy9A:
21.94
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2aeg HYPOTHETICAL PROTEIN
AGR_PAT_140


(Agrobacterium
fabrum)
PF02586
(SRAP)
5 ARG A 167
GLY A 180
PHE A 155
ASN A  99
LEU A 178
None
0.97A 4aztA-2aegA:
undetectable
4aztA-2aegA:
20.84
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2eax PEPTIDOGLYCAN
RECOGNITION
PROTEIN-I-BETA


(Homo sapiens)
PF01510
(Amidase_2)
5 TYR A 300
GLY A 236
ALA A 304
LEU A 344
ILE A 365
None
1.09A 4aztA-2eaxA:
undetectable
4aztA-2eaxA:
12.98
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2eh6 ACETYLORNITHINE
AMINOTRANSFERASE


(Aquifex
aeolicus)
PF00202
(Aminotran_3)
6 TYR A 109
GLY A 175
ALA A 106
ILE A 176
VAL A 207
ILE A 201
None
1.40A 4aztA-2eh6A:
3.1
4aztA-2eh6A:
19.72
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2eo5 419AA LONG
HYPOTHETICAL
AMINOTRANSFERASE


(Sulfurisphaera
tokodaii)
PF00202
(Aminotran_3)
5 ARG A 296
GLY A 215
ILE A 132
VAL A 124
ILE A 121
None
1.11A 4aztA-2eo5A:
undetectable
4aztA-2eo5A:
20.98
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2etv IRON(III) ABC
TRANSPORTER,
PERIPLASMIC
IRON-BINDING
PROTEIN, PUTATIVE


(Thermotoga
maritima)
PF01497
(Peripla_BP_2)
5 ALA A  48
ILE A 159
LEU A  27
VAL A 134
ILE A  34
None
MLY  A 158 (-4.3A)
None
None
None
1.13A 4aztA-2etvA:
undetectable
4aztA-2etvA:
21.24
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2i7g MONOOXYGENASE

(Agrobacterium
fabrum)
PF00296
(Bac_luciferase)
5 GLY A 316
ASN A  12
ARG A  52
VAL A 257
ILE A 261
None
0.94A 4aztA-2i7gA:
undetectable
4aztA-2i7gA:
22.90
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2iny HEXON PROTEIN

(Fowl
aviadenovirus A)
PF01065
(Adeno_hexon)
PF03678
(Adeno_hexon_C)
5 TYR A 682
GLY A 679
ASN A 858
LEU A 652
ILE A 297
None
1.08A 4aztA-2inyA:
undetectable
4aztA-2inyA:
21.05
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2ipx RRNA
2'-O-METHYLTRANSFERA
SE FIBRILLARIN


(Homo sapiens)
PF01269
(Fibrillarin)
5 GLY A 168
ALA A 170
PHE A 193
VAL A 238
ILE A 246
MTA  A4001 (-3.3A)
MTA  A4001 (-3.6A)
MTA  A4001 (-3.5A)
MTA  A4001 (-4.1A)
None
1.07A 4aztA-2ipxA:
10.2
4aztA-2ipxA:
18.87
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2oqh PUTATIVE ISOMERASE

(Streptomyces
coelicolor)
PF02746
(MR_MLE_N)
PF13378
(MR_MLE_C)
5 ARG A  61
ASN A  14
ILE A 334
VAL A  35
ILE A 304
None
0.98A 4aztA-2oqhA:
2.6
4aztA-2oqhA:
20.45
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2pvz PRPF METHYLACONITATE
ISOMERASE


(Shewanella
oneidensis)
PF04303
(PrpF)
5 GLY A 115
ALA A 113
ILE A 119
VAL A 152
ILE A 154
None
1.12A 4aztA-2pvzA:
undetectable
4aztA-2pvzA:
22.11
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2r4g TELOMERASE REVERSE
TRANSCRIPTASE


(Tetrahymena
thermophila)
PF12009
(Telomerase_RBD)
6 GLY A 457
ASN A 297
ILE A 460
LEU A 420
VAL A 419
ILE A 464
None
1.43A 4aztA-2r4gA:
undetectable
4aztA-2r4gA:
18.69
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2xa7 ADAPTOR-RELATED
PROTEIN COMPLEX 2,
ALPHA 2 SUBUNIT


(Rattus
norvegicus)
PF01602
(Adaptin_N)
5 ALA A  79
ASN A  81
ILE A 112
LEU A 101
ILE A 109
None
0.96A 4aztA-2xa7A:
undetectable
4aztA-2xa7A:
23.21
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2xfg ENDOGLUCANASE 1

(Ruminiclostridium
thermocellum)
PF00759
(Glyco_hydro_9)
5 TYR A  69
GLY A  75
ALA A  72
ILE A  94
ILE A  14
None
0.89A 4aztA-2xfgA:
undetectable
4aztA-2xfgA:
22.28
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2z8z LIPASE

(Pseudomonas sp.
MIS38)
PF00353
(HemolysinCabind)
5 GLY A 321
ALA A 317
ILE A 325
VAL A 342
ILE A 340
None
0.82A 4aztA-2z8zA:
undetectable
4aztA-2z8zA:
22.42
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3aib GLUCOSYLTRANSFERASE-
SI


(Streptococcus
mutans)
PF02324
(Glyco_hydro_70)
5 ALA A 435
ASN A 436
ILE A1053
GLU A 375
LEU A 382
None
1.11A 4aztA-3aibA:
2.8
4aztA-3aibA:
20.56
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3aq4 ADP-RIBOSYLATION
FACTOR 1


(Arabidopsis
thaliana)
PF00025
(Arf)
5 GLY A  29
ALA A  27
ILE A  33
VAL A  91
ILE A  89
GDP  A 183 (-3.3A)
GDP  A 183 (-4.3A)
None
None
None
0.89A 4aztA-3aq4A:
undetectable
4aztA-3aq4A:
15.04
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3co8 ALANINE RACEMASE

(Oenococcus oeni)
PF00842
(Ala_racemase_C)
PF01168
(Ala_racemase_N)
5 GLY A  70
ALA A  72
ILE A  84
LEU A  62
VAL A  64
None
1.13A 4aztA-3co8A:
undetectable
4aztA-3co8A:
21.47
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3db7 PUTATIVE
CALCIUM-REGULATED
PERIPLASMIC PROTEIN


(Bacteroides
thetaiotaomicron)
PF11396
(PepSY_like)
5 PHE A  43
ASN A  68
ILE A  39
LEU A  50
VAL A  64
None
None
None
EDO  A   4 ( 4.8A)
None
1.13A 4aztA-3db7A:
undetectable
4aztA-3db7A:
12.52
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3do6 FORMATE--TETRAHYDROF
OLATE LIGASE


(Thermotoga
maritima)
PF01268
(FTHFS)
5 ALA A 456
ILE A 434
GLU A 435
LEU A 511
VAL A 496
EDO  A 544 ( 4.0A)
None
None
None
None
0.96A 4aztA-3do6A:
undetectable
4aztA-3do6A:
22.39
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3fwz INNER MEMBRANE
PROTEIN YBAL


(Escherichia
coli)
PF02254
(TrkA_N)
5 ALA A 477
ILE A 498
GLU A 494
VAL A 423
ILE A 489
None
None
AMP  A 601 (-3.6A)
AMP  A 601 ( 4.9A)
AMP  A 601 (-3.6A)
1.13A 4aztA-3fwzA:
6.0
4aztA-3fwzA:
14.54
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3htx HEN1

(Arabidopsis
thaliana)
PF13847
(Methyltransf_31)
5 ARG A 701
GLY A 721
ILE A 779
LEU A 795
VAL A 797
G  B  22 (-3.9A)
SAH  A 951 (-4.3A)
SAH  A 951 (-3.9A)
SAH  A 951 (-3.9A)
SAH  A 951 (-3.9A)
0.85A 4aztA-3htxA:
11.9
4aztA-3htxA:
20.27
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ibg ATPASE, SUBUNIT OF
THE GET COMPLEX


(Aspergillus
fumigatus)
PF02374
(ArsA_ATPase)
5 ALA A  51
ASN A  88
ILE A 155
LEU A  46
ILE A  60
None
1.04A 4aztA-3ibgA:
undetectable
4aztA-3ibgA:
20.69
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3l6u ABC-TYPE SUGAR
TRANSPORT SYSTEM
PERIPLASMIC
COMPONENT


(Exiguobacterium
sibiricum)
PF13407
(Peripla_BP_4)
5 GLY A  12
ALA A  41
ILE A  68
VAL A  65
ILE A  90
None
1.11A 4aztA-3l6uA:
2.6
4aztA-3l6uA:
19.65
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3lrp ADP-RIBOSYLATION
FACTOR 1


(Plasmodium
falciparum)
PF00025
(Arf)
5 GLY A  29
ALA A  27
ILE A  33
VAL A  91
ILE A  89
GDP  A 182 (-3.1A)
GDP  A 182 (-4.3A)
None
None
None
0.94A 4aztA-3lrpA:
2.4
4aztA-3lrpA:
14.52
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3lvr ARF-GAP WITH SH3
DOMAIN, ANK REPEAT
AND PH
DOMAIN-CONTAINING
PROTEIN 3,
ADP-RIBOSYLATION
FACTOR 6


(Homo sapiens;
synthetic
construct)
PF00025
(Arf)
PF01412
(ArfGap)
PF12796
(Ank_2)
5 GLY E  25
ALA E  23
ILE E  29
VAL E  87
ILE E  85
GDP  E 737 (-3.2A)
GDP  E 737 ( 4.4A)
None
None
None
0.86A 4aztA-3lvrE:
2.5
4aztA-3lvrE:
23.13
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3m1r FORMIMIDOYLGLUTAMASE

(Bacillus
subtilis)
PF00491
(Arginase)
6 GLY A 124
ALA A  54
ILE A 122
LEU A  44
VAL A  42
ILE A  40
None
1.36A 4aztA-3m1rA:
undetectable
4aztA-3m1rA:
21.39
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3mes CHOLINE KINASE

(Cryptosporidium
parvum)
PF01633
(Choline_kinase)
5 GLY A 372
ALA A 395
ASN A 396
ILE A 369
ILE A 232
None
1.13A 4aztA-3mesA:
7.3
4aztA-3mesA:
22.26
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3n11 CHITINASE A

(Bacillus cereus)
PF00704
(Glyco_hydro_18)
5 GLY A  67
ASN A  42
ILE A 106
VAL A  76
ILE A 128
None
1.00A 4aztA-3n11A:
undetectable
4aztA-3n11A:
19.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3nd6 PHOSPHOPANTETHEINE
ADENYLYLTRANSFERASE


(Enterococcus
faecalis)
PF01467
(CTP_transf_like)
5 ALA A  26
ASN A  64
ILE A  34
LEU A  21
ILE A  55
None
None
None
ATP  A 961 (-4.4A)
None
1.14A 4aztA-3nd6A:
3.3
4aztA-3nd6A:
15.56
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3nva CTP SYNTHASE

(Sulfolobus
solfataricus)
PF00117
(GATase)
PF06418
(CTP_synth_N)
5 ALA A 136
ILE A 127
LEU A 140
VAL A  39
ILE A  90
None
0.98A 4aztA-3nvaA:
undetectable
4aztA-3nvaA:
23.31
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3o47 ADP-RIBOSYLATION
FACTOR
GTPASE-ACTIVATING
PROTEIN 1,
ADP-RIBOSYLATION
FACTOR 1


(Homo sapiens)
PF00025
(Arf)
PF01412
(ArfGap)
5 GLY A 159
ALA A 157
ILE A 163
VAL A 221
ILE A 219
GDP  A 502 (-3.2A)
GDP  A 502 (-4.4A)
None
None
None
0.85A 4aztA-3o47A:
undetectable
4aztA-3o47A:
21.95
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3p8c NCK-ASSOCIATED
PROTEIN 1


(Homo sapiens)
PF09735
(Nckap1)
5 TYR B 545
ALA B 548
ILE B 409
GLU B 413
LEU B 385
None
1.12A 4aztA-3p8cB:
undetectable
4aztA-3p8cB:
18.37
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3pbp NUCLEOPORIN
NUP116/NSP116


(Saccharomyces
cerevisiae)
PF04096
(Nucleoporin2)
5 GLY B1020
ASN B 967
ILE B1024
VAL B 995
ILE B1003
None
0.96A 4aztA-3pbpB:
undetectable
4aztA-3pbpB:
13.90
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3r38 UDP-N-ACETYLGLUCOSAM
INE
1-CARBOXYVINYLTRANSF
ERASE 1


(Listeria
monocytogenes)
PF00275
(EPSP_synthase)
5 GLY A 380
ALA A 383
ILE A 377
VAL A   6
ILE A   4
None
0.95A 4aztA-3r38A:
undetectable
4aztA-3r38A:
24.87
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3rza TRIPEPTIDASE

(Staphylococcus
aureus)
PF01546
(Peptidase_M20)
PF07687
(M20_dimer)
6 GLY A 114
ALA A 117
PHE A  11
GLU A 351
LEU A 339
VAL A 341
None
1.46A 4aztA-3rzaA:
undetectable
4aztA-3rzaA:
20.73
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3u02 PUTATIVE
TRANSCRIPTION-ASSOCI
ATED PROTEIN TFIIS


(Pyrococcus
furiosus)
PF08489
(DUF1743)
5 TYR A  79
PHE A  97
ILE A   3
VAL A  72
ILE A  69
None
0.91A 4aztA-3u02A:
undetectable
4aztA-3u02A:
19.57
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3vvd AMINO ACID ABC
TRANSPORTER, BINDING
PROTEIN


(Thermus
thermophilus)
PF00497
(SBP_bac_3)
5 GLY A  17
ALA A  77
ASN A  26
ILE A  56
LEU A  67
None
1.05A 4aztA-3vvdA:
undetectable
4aztA-3vvdA:
19.27
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3wyz RIBONUCLEASE P
PROTEIN COMPONENT 3


(Thermococcus
kodakarensis)
PF01876
(RNase_P_p30)
5 ARG A  19
GLY A  93
ILE A  98
VAL A  91
ILE A  77
GOL  A 301 (-2.9A)
None
None
None
None
1.04A 4aztA-3wyzA:
undetectable
4aztA-3wyzA:
17.07
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ayg GLUCANSUCRASE

(Lactobacillus
reuteri)
PF01473
(CW_binding_1)
PF02324
(Glyco_hydro_70)
5 ALA A 983
ASN A 984
ILE A1601
GLU A 931
LEU A 940
None
1.09A 4aztA-4aygA:
2.5
4aztA-4aygA:
20.90
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4azv WBDD

(Escherichia
coli)
PF00069
(Pkinase)
PF13847
(Methyltransf_31)
7 GLY A  61
ARG A 109
ILE A 110
GLU A 111
LEU A 128
VAL A 130
ILE A 134
SAM  A1474 (-3.2A)
SAM  A1474 (-4.8A)
SAM  A1474 (-3.8A)
SAM  A1474 (-2.5A)
SAM  A1474 (-4.3A)
SAM  A1474 ( 3.4A)
SAM  A1474 ( 4.8A)
1.06A 4aztA-4azvA:
55.9
4aztA-4azvA:
100.00
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4azv WBDD

(Escherichia
coli)
PF00069
(Pkinase)
PF13847
(Methyltransf_31)
11 TYR A  16
ARG A  36
GLY A  61
ALA A  63
PHE A  83
ASN A  87
ILE A 110
GLU A 111
LEU A 128
VAL A 130
ILE A 134
SAM  A1474 (-3.5A)
SAM  A1474 ( 3.1A)
SAM  A1474 (-3.2A)
SAM  A1474 (-3.0A)
SAM  A1474 (-3.6A)
SAM  A1474 (-3.7A)
SAM  A1474 (-3.8A)
SAM  A1474 (-2.5A)
SAM  A1474 (-4.3A)
SAM  A1474 ( 3.4A)
SAM  A1474 ( 4.8A)
0.10A 4aztA-4azvA:
55.9
4aztA-4azvA:
100.00
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4azw WBDD

(Escherichia
coli)
PF00069
(Pkinase)
PF13847
(Methyltransf_31)
9 ARG A  31
GLY A  61
PHE A  83
ASN A  87
ARG A 109
ILE A 110
GLU A 111
VAL A 130
ILE A 134
SAM  A1451 ( 4.9A)
SAM  A1451 (-3.6A)
SAM  A1451 (-3.5A)
SAM  A1451 (-4.0A)
SAM  A1451 (-3.9A)
SAM  A1451 (-4.0A)
SAM  A1451 (-3.1A)
SAM  A1451 (-4.6A)
None
1.21A 4aztA-4azwA:
49.9
4aztA-4azwA:
99.36
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4azw WBDD

(Escherichia
coli)
PF00069
(Pkinase)
PF13847
(Methyltransf_31)
12 TYR A  16
ARG A  36
GLY A  61
ALA A  63
PHE A  83
ASN A  87
ARG A 109
ILE A 110
GLU A 111
LEU A 128
VAL A 130
ILE A 134
SAM  A1451 (-3.6A)
SAM  A1451 (-3.2A)
SAM  A1451 (-3.6A)
SAM  A1451 (-3.7A)
SAM  A1451 (-3.5A)
SAM  A1451 (-4.0A)
SAM  A1451 (-3.9A)
SAM  A1451 (-4.0A)
SAM  A1451 (-3.1A)
SAM  A1451 (-4.1A)
SAM  A1451 (-4.6A)
None
0.40A 4aztA-4azwA:
49.9
4aztA-4azwA:
99.36
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4b3i FATTY ACID
BETA-OXIDATION
COMPLEX ALPHA-CHAIN
FADB


(Mycobacterium
tuberculosis)
PF00378
(ECH_1)
PF00725
(3HCDH)
PF02737
(3HCDH_N)
5 ALA A 662
PHE A 672
ASN A 663
ILE A 670
VAL A 514
None
1.06A 4aztA-4b3iA:
4.2
4aztA-4b3iA:
23.47
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4bc5 XYLULOSE KINASE

(Homo sapiens)
PF00370
(FGGY_N)
PF02782
(FGGY_C)
5 GLY A 414
ALA A 418
ARG A 391
GLU A 407
ILE A 346
None
1.04A 4aztA-4bc5A:
undetectable
4aztA-4bc5A:
23.44
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4c30 DNA HELICASE II

(Deinococcus
radiodurans)
PF00580
(UvrD-helicase)
PF13361
(UvrD_C)
5 GLY A 337
ALA A 335
ILE A 370
VAL A 340
ILE A 359
None
1.11A 4aztA-4c30A:
3.9
4aztA-4c30A:
24.13
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4dg5 PHOSPHOGLYCERATE
KINASE


(Staphylococcus
aureus)
PF00162
(PGK)
5 ALA A  78
ILE A  44
LEU A 113
VAL A 112
ILE A  48
None
1.04A 4aztA-4dg5A:
4.2
4aztA-4dg5A:
23.09
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4fme ADP-RIBOSYLATION
FACTOR 6


(Homo sapiens)
PF00025
(Arf)
5 GLY C  25
ALA C  23
ILE C  29
VAL C  87
ILE C  85
GTP  C 201 (-3.0A)
GTP  C 201 (-4.5A)
None
None
None
0.91A 4aztA-4fmeC:
undetectable
4aztA-4fmeC:
14.47
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ikv DI-TRIPEPTIDE ABC
TRANSPORTER
(PERMEASE)


(Geobacillus
kaustophilus)
PF00854
(PTR2)
5 GLY A 101
ALA A  97
ASN A 138
ILE A 105
ILE A 128
None
1.08A 4aztA-4ikvA:
undetectable
4aztA-4ikvA:
20.93
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4oja SUPEROXIDE DISMUTASE
[CU-ZN]


(Hydra vulgaris)
PF00080
(Sod_Cu)
5 GLY A  43
ALA A 139
ASN A 121
ILE A  86
ILE A  33
None
1.03A 4aztA-4ojaA:
undetectable
4aztA-4ojaA:
14.41
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4qww ACETYLCHOLINESTERASE

(Bungarus
fasciatus)
PF00135
(COesterase)
5 TYR A 375
ARG A 517
ALA A 390
VAL A 395
ILE A 287
None
1.11A 4aztA-4qwwA:
undetectable
4aztA-4qwwA:
21.58
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ru4 TAIL SPIKE PROTEIN
GP49


(Pseudomonas
virus LKA1)
PF13229
(Beta_helix)
5 GLY A 389
ASN A 409
ILE A 380
LEU A 391
ILE A 267
None
1.13A 4aztA-4ru4A:
undetectable
4aztA-4ru4A:
22.54
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4w4t MXAA

(Stigmatella
aurantiaca)
PF07993
(NAD_binding_4)
5 GLY A1262
ALA A1258
ASN A1259
ILE A1266
ILE A1239
None
1.13A 4aztA-4w4tA:
undetectable
4aztA-4w4tA:
23.31
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4x1z VP1

(Rabbit
hemorrhagic
disease virus)
PF00915
(Calici_coat)
5 GLY A 486
ALA A 464
ARG A 469
ILE A 426
ILE A 434
None
1.12A 4aztA-4x1zA:
undetectable
4aztA-4x1zA:
20.69
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4xk8 PUTATIVE
UNCHARACTERIZED
PROTEIN


(Pisum sativum)
PF02605
(PsaL)
5 GLY L  85
ALA L  83
ILE L 144
LEU L  60
VAL L 147
None
BCR  L 201 ( 3.9A)
None
None
None
0.89A 4aztA-4xk8L:
undetectable
4aztA-4xk8L:
14.79
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4xni DI-OR TRIPEPTIDE:H+
SYMPORTER


(Streptococcus
thermophilus)
PF00854
(PTR2)
5 GLY A  91
ALA A  87
ASN A 128
ILE A  95
ILE A 118
None
0.99A 4aztA-4xniA:
undetectable
4aztA-4xniA:
22.46
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ylg ADP-RIBOSYLATION
FACTOR


(Entamoeba
histolytica)
PF00025
(Arf)
5 GLY A  25
ALA A  23
ILE A  29
VAL A  87
ILE A  85
GDP  A 201 (-3.3A)
GDP  A 201 (-4.2A)
None
None
None
0.88A 4aztA-4ylgA:
undetectable
4aztA-4ylgA:
15.28
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5b48 2-OXOACID--FERREDOXI
N OXIDOREDUCTASE
ALPHA SUBUNIT


(Sulfurisphaera
tokodaii)
PF01558
(POR)
PF01855
(POR_N)
5 ARG A 455
ALA A 304
ILE A 298
VAL A 337
ILE A 339
None
1.03A 4aztA-5b48A:
3.2
4aztA-5b48A:
21.86
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5b5z PTLCIB4 H88A MUTANT

(Phaeodactylum
tricornutum)
no annotation 5 GLY A 112
ALA A 124
LEU A 196
VAL A 103
ILE A 233
None
1.03A 4aztA-5b5zA:
3.0
4aztA-5b5zA:
18.50
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5d8h 50S RIBOSOMAL
PROTEIN L11


(Methanocaldococcus
jannaschii)
PF00298
(Ribosomal_L11)
PF03946
(Ribosomal_L11_N)
5 ILE C  38
GLU C  37
LEU C   8
VAL C  52
ILE C  65
None
None
U  A1171 ( 4.4A)
None
None
1.10A 4aztA-5d8hC:
undetectable
4aztA-5d8hC:
11.93
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5efv PHI ETA ORF 56-LIKE
PROTEIN


(Staphylococcus
virus 11)
no annotation 5 GLY A 405
ALA A 386
ILE A 418
LEU A 389
ILE A 176
None
1.09A 4aztA-5efvA:
undetectable
4aztA-5efvA:
21.50
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5eoe BETA-LACTAMASE

(Pseudomonas
aeruginosa)
PF13354
(Beta-lactamase2)
6 GLY A  51
ILE A  26
GLU A  30
LEU A  41
VAL A  39
ILE A  37
None
1.03A 4aztA-5eoeA:
undetectable
4aztA-5eoeA:
19.37
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5hxb EUKARYOTIC PEPTIDE
CHAIN RELEASE FACTOR
GTP-BINDING SUBUNIT
ERF3A


(Homo sapiens)
no annotation 5 GLY X 627
ALA X 533
ILE X 626
LEU X 552
ILE X 538
85C  Z 502 (-3.8A)
None
85C  Z 502 (-3.9A)
None
None
1.13A 4aztA-5hxbX:
undetectable
4aztA-5hxbX:
14.94
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ijl DNA POLYMERASE II
LARGE SUBUNIT


(Pyrococcus
abyssi)
PF03833
(PolC_DP2)
5 GLY A  49
ALA A  44
ILE A  64
VAL A  51
ILE A 109
None
1.01A 4aztA-5ijlA:
undetectable
4aztA-5ijlA:
20.26
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ipw OLIGOPEPTIDE ABC
TRANSPORTER,
PERIPLASMIC
OLIGOPEPTIDE-BINDING
PROTEIN, PUTATIVE


(Thermotoga
maritima)
PF00496
(SBP_bac_5)
5 GLY A 362
ALA A 414
LEU A 416
VAL A 417
ILE A 358
None
1.14A 4aztA-5ipwA:
undetectable
4aztA-5ipwA:
21.85
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ir6 BD-TYPE QUINOL
OXIDASE SUBUNIT I


(Geobacillus
stearothermophilus)
PF01654
(Cyt_bd_oxida_I)
5 TYR A 389
ALA A  90
GLU A 101
VAL A 149
ILE A 146
None
None
HEB  A 502 (-3.0A)
HDD  A 503 ( 4.9A)
HDD  A 503 ( 2.9A)
1.14A 4aztA-5ir6A:
undetectable
4aztA-5ir6A:
22.78
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5kzd N-ACETYLNEURAMINATE
LYASE


(Staphylococcus
aureus)
PF00701
(DHDPS)
5 GLY A  82
ASN A  46
ILE A 126
LEU A  84
ILE A  90
None
1.06A 4aztA-5kzdA:
undetectable
4aztA-5kzdA:
19.93
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5lj6 MACROLIDE EXPORT
ATP-BINDING/PERMEASE
PROTEIN MACB


(Aggregatibacter
actinomycetemcomitans)
no annotation 5 GLY A 579
ALA A 582
ILE A 575
LEU A 273
ILE A 261
None
1.09A 4aztA-5lj6A:
undetectable
4aztA-5lj6A:
23.17
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5msy GLYCOSIDE HYDROLASE

(Bacteroides
thetaiotaomicron)
PF12904
(Collagen_bind_2)
PF13204
(DUF4038)
5 TYR A 112
GLY A 167
ALA A 165
ILE A 204
ILE A 184
None
1.03A 4aztA-5msyA:
undetectable
4aztA-5msyA:
20.95
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ng6 CRISPR-ASSOCIATED
ENDONUCLEASE CPF1


(Francisella
tularensis)
no annotation 5 GLY A1263
ALA A1259
ILE A 913
VAL A1004
ILE A1002
None
1.08A 4aztA-5ng6A:
undetectable
4aztA-5ng6A:
17.02
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5nks DIHYDROPYRIMIDINASE-
RELATED PROTEIN 4


(Homo sapiens)
no annotation 5 GLY A 450
ILE A 447
LEU A  41
VAL A  37
ILE A  19
GLY  A 450 ( 0.0A)
ILE  A 447 ( 0.6A)
LEU  A  41 ( 0.5A)
VAL  A  37 ( 0.6A)
ILE  A  19 ( 0.7A)
0.88A 4aztA-5nksA:
undetectable
4aztA-5nksA:
22.46
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5uf8 POTENTIAL
ADP-RIBOSYLATION
FACTOR


(Candida
albicans)
PF00025
(Arf)
5 GLY A  29
ALA A  27
ILE A  33
VAL A  91
ILE A  89
GDP  A 500 (-3.2A)
GDP  A 500 (-4.2A)
None
None
None
0.85A 4aztA-5uf8A:
undetectable
4aztA-5uf8A:
15.21
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5uow N-METHYL-D-ASPARTATE
RECEPTOR SUBUNIT
NR1-8A


(Xenopus laevis)
PF00060
(Lig_chan)
PF01094
(ANF_receptor)
PF10613
(Lig_chan-Glu_bd)
5 GLY A  30
ALA A  62
ILE A  90
VAL A  87
ILE A 116
None
1.12A 4aztA-5uowA:
undetectable
4aztA-5uowA:
20.27
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5wh8 PUTATIVE
CARBOHYDRATE-ACTIVE
ENZYME


(uncultured
organism)
no annotation 5 GLY A  80
PHE A 110
ILE A 109
VAL A 316
ILE A 152
None
1.12A 4aztA-5wh8A:
undetectable
4aztA-5wh8A:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5wi5 UDP-N-ACETYLGLUCOSAM
INE
1-CARBOXYVINYLTRANSF
ERASE 1


(Streptococcus
pneumoniae)
PF00275
(EPSP_synthase)
5 GLY A 384
ALA A 387
ILE A 381
VAL A   6
ILE A   4
None
0.99A 4aztA-5wi5A:
undetectable
4aztA-5wi5A:
22.57
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ys9 ACYL-COENZYME A
OXIDASE 3


(Yarrowia
lipolytica)
no annotation 5 GLY A 203
ALA A 208
ILE A 259
VAL A 124
ILE A 120
None
1.11A 4aztA-5ys9A:
undetectable
4aztA-5ys9A:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5zqj BETA-XYLOSIDASE

(Bacillus
pumilus)
no annotation 5 ALA A 406
PHE A 398
ILE A 452
VAL A 459
ILE A 456
None
1.06A 4aztA-5zqjA:
undetectable
4aztA-5zqjA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6bbp CYTOHESIN-3,ADP-RIBO
SYLATION FACTOR 6


(Homo sapiens;
Mus musculus)
no annotation 5 GLY A 423
ALA A 421
ILE A 427
VAL A 485
ILE A 483
GTP  A 601 (-3.3A)
GTP  A 601 (-4.2A)
None
None
None
0.83A 4aztA-6bbpA:
undetectable
4aztA-6bbpA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6esq HYDROXYMETHYLGLUTARY
L-COA SYNTHASE


(Methanothermococcus
thermolithotrophicus)
no annotation 6 GLY I 279
ALA I 275
ILE I 283
LEU I 263
VAL I 236
ILE I 293
None
1.29A 4aztA-6esqI:
undetectable
4aztA-6esqI:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6exs PEPTIDE ABC
TRANSPORTER PERMEASE


(Staphylococcus
hominis)
no annotation 5 GLY A 102
ALA A  98
ASN A 139
ILE A 106
ILE A 129
None
0.96A 4aztA-6exsA:
undetectable
4aztA-6exsA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6fae ADP-RIBOSYLATION
FACTOR 1


(Homo sapiens)
no annotation 5 GLY B  29
ALA B  27
ILE B  33
VAL B  91
ILE B  89
None
0.85A 4aztA-6faeB:
undetectable
4aztA-6faeB:
undetectable