SIMILAR PATTERNS OF AMINO ACIDS FOR 4AZT_A_SAMA1472

List of similar pattern of amino acids derived from ASSAM search

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click link on the last column to view superposed patterns of amino acids in NGL viewer)
(Note that only 3-12 residue patterns can be used for ASSAM searches)
Filter list by:
Hit Macromolecule/
Organism		 Pfam Res. Interface HETATM RMSD Dali Z-score Seq. Identity (%) View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1a2o CHEB METHYLESTERASE

(Salmonella
enterica) 		PF00072
(Response_reg)
PF01339
(CheB_methylest) 		5 GLY A 166
ALA A 170
ILE A 102
VAL A 310
ILE A 135
 None
 1.11A 4aztA-1a2oA:
3.6		 4aztA-1a2oA:
22.85
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ebd DIHYDROLIPOAMIDE
DEHYDROGENASE

(Geobacillus
stearothermophilus) 		PF02852
(Pyr_redox_dim)
PF07992
(Pyr_redox_2) 		5 GLY A 192
ALA A 194
ASN A 197
ILE A 204
ILE A 211
 None
 0.87A 4aztA-1ebdA:
4.1		 4aztA-1ebdA:
22.49
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1eom ENDO-BETA-N-ACETYLGL
UCOSAMINIDASE F3

(Elizabethkingia
meningoseptica) 		PF00704
(Glyco_hydro_18) 		5 ARG A  73
GLY A 122
ILE A 123
VAL A 114
ILE A 110
 None
 1.06A 4aztA-1eomA:
undetectable		 4aztA-1eomA:
17.75
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1es6 MATRIX PROTEIN VP40

(Ebola virus sp.) 		PF07447
(VP40) 		5 ALA A 318
ILE A 216
LEU A 288
VAL A 287
ILE A 261
 None
 1.07A 4aztA-1es6A:
undetectable		 4aztA-1es6A:
19.08
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1gpp ENDONUCLEASE PI-SCEI

(Saccharomyces
cerevisiae) 		PF05203
(Hom_end_hint) 		5 ALA A  11
ILE A 434
LEU A 445
VAL A   8
ILE A  18
 None
 1.09A 4aztA-1gppA:
undetectable		 4aztA-1gppA:
19.33
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1hq0 CYTOTOXIC
NECROTIZING FACTOR 1

(Escherichia
coli) 		PF05785
(CNF1) 		5 GLY A 842
ALA A 840
ILE A 843
VAL A 833
ILE A 858
 None
 1.11A 4aztA-1hq0A:
undetectable		 4aztA-1hq0A:
19.28
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1j6o TATD-RELATED
DEOXYRIBONUCLEASE

(Thermotoga
maritima) 		PF01026
(TatD_DNase) 		5 ALA A 183
PHE A 153
ILE A 172
VAL A 188
ILE A 196
 None
 1.12A 4aztA-1j6oA:
undetectable		 4aztA-1j6oA:
19.86
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1jy1 TYROSYL-DNA
PHOSPHODIESTERASE

(Homo sapiens) 		PF06087
(Tyr-DNA_phospho) 		5 TYR A 302
ILE A 188
LEU A 268
VAL A 278
ILE A 296
 None
 1.11A 4aztA-1jy1A:
2.0		 4aztA-1jy1A:
21.55
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1nzn FISSION PROTEIN
FIS1P

(Homo sapiens) 		PF14852
(Fis1_TPR_N)
PF14853
(Fis1_TPR_C) 		5 TYR A  96
GLY A  83
ALA A  81
ILE A  54
LEU A  61
 None
 1.10A 4aztA-1nznA:
undetectable		 4aztA-1nznA:
14.62
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1pc2 MITOCHONDRIA FISSION
PROTEIN

(Homo sapiens) 		PF14852
(Fis1_TPR_N)
PF14853
(Fis1_TPR_C) 		5 TYR A  93
GLY A  80
ALA A  78
ILE A  51
LEU A  58
 None
 1.11A 4aztA-1pc2A:
undetectable		 4aztA-1pc2A:
14.44
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1rf5 5-ENOLPYRUVYLSHIKIMA
TE-3-PHOSPHATE
SYNTHASE

(Streptococcus
pneumoniae) 		PF00275
(EPSP_synthase) 		5 GLY A  30
ALA A  33
ILE A  27
VAL A  71
ILE A  69
 None
 1.07A 4aztA-1rf5A:
undetectable		 4aztA-1rf5A:
21.60
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1suw PROBABLE INORGANIC
POLYPHOSPHATE/ATP-NA
D KINASE

(Archaeoglobus
fulgidus) 		PF01513
(NAD_kinase) 		5 GLY A  67
ALA A  79
PHE A 232
ILE A  65
ILE A  43
 None
 1.11A 4aztA-1suwA:
undetectable		 4aztA-1suwA:
17.75
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1tjr BX1

(Zea mays) 		PF00290
(Trp_syntA) 		5 GLY A 322
ALA A 324
LEU A 334
VAL A 318
ILE A 149
 None
 1.13A 4aztA-1tjrA:
undetectable		 4aztA-1tjrA:
19.72
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1v71 HYPOTHETICAL PROTEIN
C320.14 IN
CHROMOSOME III

(Schizosaccharomyces
pombe) 		PF00291
(PALP) 		5 ARG A 316
GLY A 284
ILE A 307
VAL A 280
ILE A 278
 None
PLP  A 350 ( 4.8A)
None
None
None
 1.11A 4aztA-1v71A:
2.7		 4aztA-1v71A:
21.31
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1z0u PROBABLE INORGANIC
POLYPHOSPHATE/ATP-NA
D KINASE

(Archaeoglobus
fulgidus) 		PF01513
(NAD_kinase) 		5 GLY A  67
ALA A  79
PHE A 232
ILE A  65
ILE A  43
 None
 1.06A 4aztA-1z0uA:
undetectable		 4aztA-1z0uA:
19.28
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1z6x ADP-RIBOSYLATION
FACTOR 4

(Homo sapiens) 		PF00025
(Arf) 		5 GLY A  29
ALA A  27
ILE A  33
VAL A  91
ILE A  89
 GDP  A 201 (-3.0A)
GDP  A 201 (-4.1A)
None
None
None
 0.89A 4aztA-1z6xA:
undetectable		 4aztA-1z6xA:
14.39
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1z8w PYRROLIDONE-CARBOXYL
ATE PEPTIDASE

(Pyrococcus
furiosus) 		PF01470
(Peptidase_C15) 		6 ALA A  23
ILE A 200
GLU A 201
LEU A   4
VAL A  36
ILE A  31
 None
 1.27A 4aztA-1z8wA:
undetectable		 4aztA-1z8wA:
17.13
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1zjk MANNAN-BINDING
LECTIN SERINE
PROTEASE 2

(Homo sapiens) 		PF00084
(Sushi)
PF00089
(Trypsin) 		5 GLY A 470
ALA A 636
ILE A 462
LEU A 472
VAL A 478
 None
 1.12A 4aztA-1zjkA:
undetectable		 4aztA-1zjkA:
20.61
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1zy9 ALPHA-GALACTOSIDASE

(Thermotoga
maritima) 		PF02065
(Melibiase) 		5 GLY A 351
ALA A 347
ILE A 355
LEU A 298
ILE A 326
 None
 1.02A 4aztA-1zy9A:
undetectable		 4aztA-1zy9A:
21.94
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2aeg HYPOTHETICAL PROTEIN
AGR_PAT_140

(Agrobacterium
fabrum) 		PF02586
(SRAP) 		5 ARG A 167
GLY A 180
PHE A 155
ASN A  99
LEU A 178
 None
 0.97A 4aztA-2aegA:
undetectable		 4aztA-2aegA:
20.84
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2eax PEPTIDOGLYCAN
RECOGNITION
PROTEIN-I-BETA

(Homo sapiens) 		PF01510
(Amidase_2) 		5 TYR A 300
GLY A 236
ALA A 304
LEU A 344
ILE A 365
 None
 1.09A 4aztA-2eaxA:
undetectable		 4aztA-2eaxA:
12.98
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2eh6 ACETYLORNITHINE
AMINOTRANSFERASE

(Aquifex
aeolicus) 		PF00202
(Aminotran_3) 		6 TYR A 109
GLY A 175
ALA A 106
ILE A 176
VAL A 207
ILE A 201
 None
 1.40A 4aztA-2eh6A:
3.1		 4aztA-2eh6A:
19.72
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2eo5 419AA LONG
HYPOTHETICAL
AMINOTRANSFERASE

(Sulfurisphaera
tokodaii) 		PF00202
(Aminotran_3) 		5 ARG A 296
GLY A 215
ILE A 132
VAL A 124
ILE A 121
 None
 1.11A 4aztA-2eo5A:
undetectable		 4aztA-2eo5A:
20.98
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2etv IRON(III) ABC
TRANSPORTER,
PERIPLASMIC
IRON-BINDING
PROTEIN, PUTATIVE

(Thermotoga
maritima) 		PF01497
(Peripla_BP_2) 		5 ALA A  48
ILE A 159
LEU A  27
VAL A 134
ILE A  34
 None
MLY  A 158 (-4.3A)
None
None
None
 1.13A 4aztA-2etvA:
undetectable		 4aztA-2etvA:
21.24
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2i7g MONOOXYGENASE

(Agrobacterium
fabrum) 		PF00296
(Bac_luciferase) 		5 GLY A 316
ASN A  12
ARG A  52
VAL A 257
ILE A 261
 None
 0.94A 4aztA-2i7gA:
undetectable		 4aztA-2i7gA:
22.90
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2iny HEXON PROTEIN

(Fowl
aviadenovirus A) 		PF01065
(Adeno_hexon)
PF03678
(Adeno_hexon_C) 		5 TYR A 682
GLY A 679
ASN A 858
LEU A 652
ILE A 297
 None
 1.08A 4aztA-2inyA:
undetectable		 4aztA-2inyA:
21.05
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2ipx RRNA
2'-O-METHYLTRANSFERA
SE FIBRILLARIN

(Homo sapiens) 		PF01269
(Fibrillarin) 		5 GLY A 168
ALA A 170
PHE A 193
VAL A 238
ILE A 246
 MTA  A4001 (-3.3A)
MTA  A4001 (-3.6A)
MTA  A4001 (-3.5A)
MTA  A4001 (-4.1A)
None
 1.07A 4aztA-2ipxA:
10.2		 4aztA-2ipxA:
18.87
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2oqh PUTATIVE ISOMERASE

(Streptomyces
coelicolor) 		PF02746
(MR_MLE_N)
PF13378
(MR_MLE_C) 		5 ARG A  61
ASN A  14
ILE A 334
VAL A  35
ILE A 304
 None
 0.98A 4aztA-2oqhA:
2.6		 4aztA-2oqhA:
20.45
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2pvz PRPF METHYLACONITATE
ISOMERASE

(Shewanella
oneidensis) 		PF04303
(PrpF) 		5 GLY A 115
ALA A 113
ILE A 119
VAL A 152
ILE A 154
 None
 1.12A 4aztA-2pvzA:
undetectable		 4aztA-2pvzA:
22.11
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2r4g TELOMERASE REVERSE
TRANSCRIPTASE

(Tetrahymena
thermophila) 		PF12009
(Telomerase_RBD) 		6 GLY A 457
ASN A 297
ILE A 460
LEU A 420
VAL A 419
ILE A 464
 None
 1.43A 4aztA-2r4gA:
undetectable		 4aztA-2r4gA:
18.69
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2xa7 ADAPTOR-RELATED
PROTEIN COMPLEX 2,
ALPHA 2 SUBUNIT

(Rattus
norvegicus) 		PF01602
(Adaptin_N) 		5 ALA A  79
ASN A  81
ILE A 112
LEU A 101
ILE A 109
 None
 0.96A 4aztA-2xa7A:
undetectable		 4aztA-2xa7A:
23.21
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2xfg ENDOGLUCANASE 1

(Ruminiclostridium
thermocellum) 		PF00759
(Glyco_hydro_9) 		5 TYR A  69
GLY A  75
ALA A  72
ILE A  94
ILE A  14
 None
 0.89A 4aztA-2xfgA:
undetectable		 4aztA-2xfgA:
22.28
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2z8z LIPASE

(Pseudomonas sp.
MIS38) 		PF00353
(HemolysinCabind) 		5 GLY A 321
ALA A 317
ILE A 325
VAL A 342
ILE A 340
 None
 0.82A 4aztA-2z8zA:
undetectable		 4aztA-2z8zA:
22.42
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3aib GLUCOSYLTRANSFERASE-
SI

(Streptococcus
mutans) 		PF02324
(Glyco_hydro_70) 		5 ALA A 435
ASN A 436
ILE A1053
GLU A 375
LEU A 382
 None
 1.11A 4aztA-3aibA:
2.8		 4aztA-3aibA:
20.56
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3aq4 ADP-RIBOSYLATION
FACTOR 1

(Arabidopsis
thaliana) 		PF00025
(Arf) 		5 GLY A  29
ALA A  27
ILE A  33
VAL A  91
ILE A  89
 GDP  A 183 (-3.3A)
GDP  A 183 (-4.3A)
None
None
None
 0.89A 4aztA-3aq4A:
undetectable		 4aztA-3aq4A:
15.04
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3co8 ALANINE RACEMASE

(Oenococcus oeni) 		PF00842
(Ala_racemase_C)
PF01168
(Ala_racemase_N) 		5 GLY A  70
ALA A  72
ILE A  84
LEU A  62
VAL A  64
 None
 1.13A 4aztA-3co8A:
undetectable		 4aztA-3co8A:
21.47
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3db7 PUTATIVE
CALCIUM-REGULATED
PERIPLASMIC PROTEIN

(Bacteroides
thetaiotaomicron) 		PF11396
(PepSY_like) 		5 PHE A  43
ASN A  68
ILE A  39
LEU A  50
VAL A  64
 None
None
None
EDO  A   4 ( 4.8A)
None
 1.13A 4aztA-3db7A:
undetectable		 4aztA-3db7A:
12.52
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3do6 FORMATE--TETRAHYDROF
OLATE LIGASE

(Thermotoga
maritima) 		PF01268
(FTHFS) 		5 ALA A 456
ILE A 434
GLU A 435
LEU A 511
VAL A 496
 EDO  A 544 ( 4.0A)
None
None
None
None
 0.96A 4aztA-3do6A:
undetectable		 4aztA-3do6A:
22.39
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3fwz INNER MEMBRANE
PROTEIN YBAL

(Escherichia
coli) 		PF02254
(TrkA_N) 		5 ALA A 477
ILE A 498
GLU A 494
VAL A 423
ILE A 489
 None
None
AMP  A 601 (-3.6A)
AMP  A 601 ( 4.9A)
AMP  A 601 (-3.6A)
 1.13A 4aztA-3fwzA:
6.0		 4aztA-3fwzA:
14.54
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3htx HEN1

(Arabidopsis
thaliana) 		PF13847
(Methyltransf_31) 		5 ARG A 701
GLY A 721
ILE A 779
LEU A 795
VAL A 797
 G  B  22 (-3.9A)
SAH  A 951 (-4.3A)
SAH  A 951 (-3.9A)
SAH  A 951 (-3.9A)
SAH  A 951 (-3.9A)
 0.85A 4aztA-3htxA:
11.9		 4aztA-3htxA:
20.27
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ibg ATPASE, SUBUNIT OF
THE GET COMPLEX

(Aspergillus
fumigatus) 		PF02374
(ArsA_ATPase) 		5 ALA A  51
ASN A  88
ILE A 155
LEU A  46
ILE A  60
 None
 1.04A 4aztA-3ibgA:
undetectable		 4aztA-3ibgA:
20.69
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3l6u ABC-TYPE SUGAR
TRANSPORT SYSTEM
PERIPLASMIC
COMPONENT

(Exiguobacterium
sibiricum) 		PF13407
(Peripla_BP_4) 		5 GLY A  12
ALA A  41
ILE A  68
VAL A  65
ILE A  90
 None
 1.11A 4aztA-3l6uA:
2.6		 4aztA-3l6uA:
19.65
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3lrp ADP-RIBOSYLATION
FACTOR 1

(Plasmodium
falciparum) 		PF00025
(Arf) 		5 GLY A  29
ALA A  27
ILE A  33
VAL A  91
ILE A  89
 GDP  A 182 (-3.1A)
GDP  A 182 (-4.3A)
None
None
None
 0.94A 4aztA-3lrpA:
2.4		 4aztA-3lrpA:
14.52
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3lvr ARF-GAP WITH SH3
DOMAIN, ANK REPEAT
AND PH
DOMAIN-CONTAINING
PROTEIN 3,
ADP-RIBOSYLATION
FACTOR 6

(Homo sapiens;
synthetic
construct) 		PF00025
(Arf)
PF01412
(ArfGap)
PF12796
(Ank_2) 		5 GLY E  25
ALA E  23
ILE E  29
VAL E  87
ILE E  85
 GDP  E 737 (-3.2A)
GDP  E 737 ( 4.4A)
None
None
None
 0.86A 4aztA-3lvrE:
2.5		 4aztA-3lvrE:
23.13
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3m1r FORMIMIDOYLGLUTAMASE

(Bacillus
subtilis) 		PF00491
(Arginase) 		6 GLY A 124
ALA A  54
ILE A 122
LEU A  44
VAL A  42
ILE A  40
 None
 1.36A 4aztA-3m1rA:
undetectable		 4aztA-3m1rA:
21.39
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3mes CHOLINE KINASE

(Cryptosporidium
parvum) 		PF01633
(Choline_kinase) 		5 GLY A 372
ALA A 395
ASN A 396
ILE A 369
ILE A 232
 None
 1.13A 4aztA-3mesA:
7.3		 4aztA-3mesA:
22.26
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3n11 CHITINASE A

(Bacillus cereus) 		PF00704
(Glyco_hydro_18) 		5 GLY A  67
ASN A  42
ILE A 106
VAL A  76
ILE A 128
 None
 1.00A 4aztA-3n11A:
undetectable		 4aztA-3n11A:
19.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3nd6 PHOSPHOPANTETHEINE
ADENYLYLTRANSFERASE

(Enterococcus
faecalis) 		PF01467
(CTP_transf_like) 		5 ALA A  26
ASN A  64
ILE A  34
LEU A  21
ILE A  55
 None
None
None
ATP  A 961 (-4.4A)
None
 1.14A 4aztA-3nd6A:
3.3		 4aztA-3nd6A:
15.56
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3nva CTP SYNTHASE

(Sulfolobus
solfataricus) 		PF00117
(GATase)
PF06418
(CTP_synth_N) 		5 ALA A 136
ILE A 127
LEU A 140
VAL A  39
ILE A  90
 None
 0.98A 4aztA-3nvaA:
undetectable		 4aztA-3nvaA:
23.31
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3o47 ADP-RIBOSYLATION
FACTOR
GTPASE-ACTIVATING
PROTEIN 1,
ADP-RIBOSYLATION
FACTOR 1

(Homo sapiens) 		PF00025
(Arf)
PF01412
(ArfGap) 		5 GLY A 159
ALA A 157
ILE A 163
VAL A 221
ILE A 219
 GDP  A 502 (-3.2A)
GDP  A 502 (-4.4A)
None
None
None
 0.85A 4aztA-3o47A:
undetectable		 4aztA-3o47A:
21.95
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3p8c NCK-ASSOCIATED
PROTEIN 1

(Homo sapiens) 		PF09735
(Nckap1) 		5 TYR B 545
ALA B 548
ILE B 409
GLU B 413
LEU B 385
 None
 1.12A 4aztA-3p8cB:
undetectable		 4aztA-3p8cB:
18.37
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3pbp NUCLEOPORIN
NUP116/NSP116

(Saccharomyces
cerevisiae) 		PF04096
(Nucleoporin2) 		5 GLY B1020
ASN B 967
ILE B1024
VAL B 995
ILE B1003
 None
 0.96A 4aztA-3pbpB:
undetectable		 4aztA-3pbpB:
13.90
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3r38 UDP-N-ACETYLGLUCOSAM
INE
1-CARBOXYVINYLTRANSF
ERASE 1

(Listeria
monocytogenes) 		PF00275
(EPSP_synthase) 		5 GLY A 380
ALA A 383
ILE A 377
VAL A   6
ILE A   4
 None
 0.95A 4aztA-3r38A:
undetectable		 4aztA-3r38A:
24.87
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3rza TRIPEPTIDASE

(Staphylococcus
aureus) 		PF01546
(Peptidase_M20)
PF07687
(M20_dimer) 		6 GLY A 114
ALA A 117
PHE A  11
GLU A 351
LEU A 339
VAL A 341
 None
 1.46A 4aztA-3rzaA:
undetectable		 4aztA-3rzaA:
20.73
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3u02 PUTATIVE
TRANSCRIPTION-ASSOCI
ATED PROTEIN TFIIS

(Pyrococcus
furiosus) 		PF08489
(DUF1743) 		5 TYR A  79
PHE A  97
ILE A   3
VAL A  72
ILE A  69
 None
 0.91A 4aztA-3u02A:
undetectable		 4aztA-3u02A:
19.57
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3vvd AMINO ACID ABC
TRANSPORTER, BINDING
PROTEIN

(Thermus
thermophilus) 		PF00497
(SBP_bac_3) 		5 GLY A  17
ALA A  77
ASN A  26
ILE A  56
LEU A  67
 None
 1.05A 4aztA-3vvdA:
undetectable		 4aztA-3vvdA:
19.27
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3wyz RIBONUCLEASE P
PROTEIN COMPONENT 3

(Thermococcus
kodakarensis) 		PF01876
(RNase_P_p30) 		5 ARG A  19
GLY A  93
ILE A  98
VAL A  91
ILE A  77
 GOL  A 301 (-2.9A)
None
None
None
None
 1.04A 4aztA-3wyzA:
undetectable		 4aztA-3wyzA:
17.07
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ayg GLUCANSUCRASE

(Lactobacillus
reuteri) 		PF01473
(CW_binding_1)
PF02324
(Glyco_hydro_70) 		5 ALA A 983
ASN A 984
ILE A1601
GLU A 931
LEU A 940
 None
 1.09A 4aztA-4aygA:
2.5		 4aztA-4aygA:
20.90
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4azv WBDD

(Escherichia
coli) 		PF00069
(Pkinase)
PF13847
(Methyltransf_31) 		7 GLY A  61
ARG A 109
ILE A 110
GLU A 111
LEU A 128
VAL A 130
ILE A 134
 SAM  A1474 (-3.2A)
SAM  A1474 (-4.8A)
SAM  A1474 (-3.8A)
SAM  A1474 (-2.5A)
SAM  A1474 (-4.3A)
SAM  A1474 ( 3.4A)
SAM  A1474 ( 4.8A)
 1.06A 4aztA-4azvA:
55.9		 4aztA-4azvA:
100.00
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4azv WBDD

(Escherichia
coli) 		PF00069
(Pkinase)
PF13847
(Methyltransf_31) 		11 TYR A  16
ARG A  36
GLY A  61
ALA A  63
PHE A  83
ASN A  87
ILE A 110
GLU A 111
LEU A 128
VAL A 130
ILE A 134
 SAM  A1474 (-3.5A)
SAM  A1474 ( 3.1A)
SAM  A1474 (-3.2A)
SAM  A1474 (-3.0A)
SAM  A1474 (-3.6A)
SAM  A1474 (-3.7A)
SAM  A1474 (-3.8A)
SAM  A1474 (-2.5A)
SAM  A1474 (-4.3A)
SAM  A1474 ( 3.4A)
SAM  A1474 ( 4.8A)
 0.10A 4aztA-4azvA:
55.9		 4aztA-4azvA:
100.00
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4azw WBDD

(Escherichia
coli) 		PF00069
(Pkinase)
PF13847
(Methyltransf_31) 		9 ARG A  31
GLY A  61
PHE A  83
ASN A  87
ARG A 109
ILE A 110
GLU A 111
VAL A 130
ILE A 134
 SAM  A1451 ( 4.9A)
SAM  A1451 (-3.6A)
SAM  A1451 (-3.5A)
SAM  A1451 (-4.0A)
SAM  A1451 (-3.9A)
SAM  A1451 (-4.0A)
SAM  A1451 (-3.1A)
SAM  A1451 (-4.6A)
None
 1.21A 4aztA-4azwA:
49.9		 4aztA-4azwA:
99.36
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4azw WBDD

(Escherichia
coli) 		PF00069
(Pkinase)
PF13847
(Methyltransf_31) 		12 TYR A  16
ARG A  36
GLY A  61
ALA A  63
PHE A  83
ASN A  87
ARG A 109
ILE A 110
GLU A 111
LEU A 128
VAL A 130
ILE A 134
 SAM  A1451 (-3.6A)
SAM  A1451 (-3.2A)
SAM  A1451 (-3.6A)
SAM  A1451 (-3.7A)
SAM  A1451 (-3.5A)
SAM  A1451 (-4.0A)
SAM  A1451 (-3.9A)
SAM  A1451 (-4.0A)
SAM  A1451 (-3.1A)
SAM  A1451 (-4.1A)
SAM  A1451 (-4.6A)
None
 0.40A 4aztA-4azwA:
49.9		 4aztA-4azwA:
99.36
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4b3i FATTY ACID
BETA-OXIDATION
COMPLEX ALPHA-CHAIN
FADB

(Mycobacterium
tuberculosis) 		PF00378
(ECH_1)
PF00725
(3HCDH)
PF02737
(3HCDH_N) 		5 ALA A 662
PHE A 672
ASN A 663
ILE A 670
VAL A 514
 None
 1.06A 4aztA-4b3iA:
4.2		 4aztA-4b3iA:
23.47
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4bc5 XYLULOSE KINASE

(Homo sapiens) 		PF00370
(FGGY_N)
PF02782
(FGGY_C) 		5 GLY A 414
ALA A 418
ARG A 391
GLU A 407
ILE A 346
 None
 1.04A 4aztA-4bc5A:
undetectable		 4aztA-4bc5A:
23.44
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4c30 DNA HELICASE II

(Deinococcus
radiodurans) 		PF00580
(UvrD-helicase)
PF13361
(UvrD_C) 		5 GLY A 337
ALA A 335
ILE A 370
VAL A 340
ILE A 359
 None
 1.11A 4aztA-4c30A:
3.9		 4aztA-4c30A:
24.13
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4dg5 PHOSPHOGLYCERATE
KINASE

(Staphylococcus
aureus) 		PF00162
(PGK) 		5 ALA A  78
ILE A  44
LEU A 113
VAL A 112
ILE A  48
 None
 1.04A 4aztA-4dg5A:
4.2		 4aztA-4dg5A:
23.09
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4fme ADP-RIBOSYLATION
FACTOR 6

(Homo sapiens) 		PF00025
(Arf) 		5 GLY C  25
ALA C  23
ILE C  29
VAL C  87
ILE C  85
 GTP  C 201 (-3.0A)
GTP  C 201 (-4.5A)
None
None
None
 0.91A 4aztA-4fmeC:
undetectable		 4aztA-4fmeC:
14.47
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ikv DI-TRIPEPTIDE ABC
TRANSPORTER
(PERMEASE)

(Geobacillus
kaustophilus) 		PF00854
(PTR2) 		5 GLY A 101
ALA A  97
ASN A 138
ILE A 105
ILE A 128
 None
 1.08A 4aztA-4ikvA:
undetectable		 4aztA-4ikvA:
20.93
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4oja SUPEROXIDE DISMUTASE
[CU-ZN]

(Hydra vulgaris) 		PF00080
(Sod_Cu) 		5 GLY A  43
ALA A 139
ASN A 121
ILE A  86
ILE A  33
 None
 1.03A 4aztA-4ojaA:
undetectable		 4aztA-4ojaA:
14.41
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4qww ACETYLCHOLINESTERASE

(Bungarus
fasciatus) 		PF00135
(COesterase) 		5 TYR A 375
ARG A 517
ALA A 390
VAL A 395
ILE A 287
 None
 1.11A 4aztA-4qwwA:
undetectable		 4aztA-4qwwA:
21.58
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ru4 TAIL SPIKE PROTEIN
GP49

(Pseudomonas
virus LKA1) 		PF13229
(Beta_helix) 		5 GLY A 389
ASN A 409
ILE A 380
LEU A 391
ILE A 267
 None
 1.13A 4aztA-4ru4A:
undetectable		 4aztA-4ru4A:
22.54
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4w4t MXAA

(Stigmatella
aurantiaca) 		PF07993
(NAD_binding_4) 		5 GLY A1262
ALA A1258
ASN A1259
ILE A1266
ILE A1239
 None
 1.13A 4aztA-4w4tA:
undetectable		 4aztA-4w4tA:
23.31
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4x1z VP1

(Rabbit
hemorrhagic
disease virus) 		PF00915
(Calici_coat) 		5 GLY A 486
ALA A 464
ARG A 469
ILE A 426
ILE A 434
 None
 1.12A 4aztA-4x1zA:
undetectable		 4aztA-4x1zA:
20.69
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4xk8 PUTATIVE
UNCHARACTERIZED
PROTEIN

(Pisum sativum) 		PF02605
(PsaL) 		5 GLY L  85
ALA L  83
ILE L 144
LEU L  60
VAL L 147
 None
BCR  L 201 ( 3.9A)
None
None
None
 0.89A 4aztA-4xk8L:
undetectable		 4aztA-4xk8L:
14.79
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4xni DI-OR TRIPEPTIDE:H+
SYMPORTER

(Streptococcus
thermophilus) 		PF00854
(PTR2) 		5 GLY A  91
ALA A  87
ASN A 128
ILE A  95
ILE A 118
 None
 0.99A 4aztA-4xniA:
undetectable		 4aztA-4xniA:
22.46
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ylg ADP-RIBOSYLATION
FACTOR

(Entamoeba
histolytica) 		PF00025
(Arf) 		5 GLY A  25
ALA A  23
ILE A  29
VAL A  87
ILE A  85
 GDP  A 201 (-3.3A)
GDP  A 201 (-4.2A)
None
None
None
 0.88A 4aztA-4ylgA:
undetectable		 4aztA-4ylgA:
15.28
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5b48 2-OXOACID--FERREDOXI
N OXIDOREDUCTASE
ALPHA SUBUNIT

(Sulfurisphaera
tokodaii) 		PF01558
(POR)
PF01855
(POR_N) 		5 ARG A 455
ALA A 304
ILE A 298
VAL A 337
ILE A 339
 None
 1.03A 4aztA-5b48A:
3.2		 4aztA-5b48A:
21.86
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5b5z PTLCIB4 H88A MUTANT

(Phaeodactylum
tricornutum) 		no annotation 5 GLY A 112
ALA A 124
LEU A 196
VAL A 103
ILE A 233
 None
 1.03A 4aztA-5b5zA:
3.0		 4aztA-5b5zA:
18.50
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5d8h 50S RIBOSOMAL
PROTEIN L11

(Methanocaldococcus
jannaschii) 		PF00298
(Ribosomal_L11)
PF03946
(Ribosomal_L11_N) 		5 ILE C  38
GLU C  37
LEU C   8
VAL C  52
ILE C  65
 None
None
U  A1171 ( 4.4A)
None
None
 1.10A 4aztA-5d8hC:
undetectable		 4aztA-5d8hC:
11.93
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5efv PHI ETA ORF 56-LIKE
PROTEIN

(Staphylococcus
virus 11) 		no annotation 5 GLY A 405
ALA A 386
ILE A 418
LEU A 389
ILE A 176
 None
 1.09A 4aztA-5efvA:
undetectable		 4aztA-5efvA:
21.50
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5eoe BETA-LACTAMASE

(Pseudomonas
aeruginosa) 		PF13354
(Beta-lactamase2) 		6 GLY A  51
ILE A  26
GLU A  30
LEU A  41
VAL A  39
ILE A  37
 None
 1.03A 4aztA-5eoeA:
undetectable		 4aztA-5eoeA:
19.37
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5hxb EUKARYOTIC PEPTIDE
CHAIN RELEASE FACTOR
GTP-BINDING SUBUNIT
ERF3A

(Homo sapiens) 		no annotation 5 GLY X 627
ALA X 533
ILE X 626
LEU X 552
ILE X 538
 85C  Z 502 (-3.8A)
None
85C  Z 502 (-3.9A)
None
None
 1.13A 4aztA-5hxbX:
undetectable		 4aztA-5hxbX:
14.94
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ijl DNA POLYMERASE II
LARGE SUBUNIT

(Pyrococcus
abyssi) 		PF03833
(PolC_DP2) 		5 GLY A  49
ALA A  44
ILE A  64
VAL A  51
ILE A 109
 None
 1.01A 4aztA-5ijlA:
undetectable		 4aztA-5ijlA:
20.26
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ipw OLIGOPEPTIDE ABC
TRANSPORTER,
PERIPLASMIC
OLIGOPEPTIDE-BINDING
PROTEIN, PUTATIVE

(Thermotoga
maritima) 		PF00496
(SBP_bac_5) 		5 GLY A 362
ALA A 414
LEU A 416
VAL A 417
ILE A 358
 None
 1.14A 4aztA-5ipwA:
undetectable		 4aztA-5ipwA:
21.85
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ir6 BD-TYPE QUINOL
OXIDASE SUBUNIT I

(Geobacillus
stearothermophilus) 		PF01654
(Cyt_bd_oxida_I) 		5 TYR A 389
ALA A  90
GLU A 101
VAL A 149
ILE A 146
 None
None
HEB  A 502 (-3.0A)
HDD  A 503 ( 4.9A)
HDD  A 503 ( 2.9A)
 1.14A 4aztA-5ir6A:
undetectable		 4aztA-5ir6A:
22.78
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5kzd N-ACETYLNEURAMINATE
LYASE

(Staphylococcus
aureus) 		PF00701
(DHDPS) 		5 GLY A  82
ASN A  46
ILE A 126
LEU A  84
ILE A  90
 None
 1.06A 4aztA-5kzdA:
undetectable		 4aztA-5kzdA:
19.93
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5lj6 MACROLIDE EXPORT
ATP-BINDING/PERMEASE
PROTEIN MACB

(Aggregatibacter
actinomycetemcomitans) 		no annotation 5 GLY A 579
ALA A 582
ILE A 575
LEU A 273
ILE A 261
 None
 1.09A 4aztA-5lj6A:
undetectable		 4aztA-5lj6A:
23.17
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5msy GLYCOSIDE HYDROLASE

(Bacteroides
thetaiotaomicron) 		PF12904
(Collagen_bind_2)
PF13204
(DUF4038) 		5 TYR A 112
GLY A 167
ALA A 165
ILE A 204
ILE A 184
 None
 1.03A 4aztA-5msyA:
undetectable		 4aztA-5msyA:
20.95
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ng6 CRISPR-ASSOCIATED
ENDONUCLEASE CPF1

(Francisella
tularensis) 		no annotation 5 GLY A1263
ALA A1259
ILE A 913
VAL A1004
ILE A1002
 None
 1.08A 4aztA-5ng6A:
undetectable		 4aztA-5ng6A:
17.02
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5nks DIHYDROPYRIMIDINASE-
RELATED PROTEIN 4

(Homo sapiens) 		no annotation 5 GLY A 450
ILE A 447
LEU A  41
VAL A  37
ILE A  19
 GLY  A 450 ( 0.0A)
ILE  A 447 ( 0.6A)
LEU  A  41 ( 0.5A)
VAL  A  37 ( 0.6A)
ILE  A  19 ( 0.7A)
 0.88A 4aztA-5nksA:
undetectable		 4aztA-5nksA:
22.46
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5uf8 POTENTIAL
ADP-RIBOSYLATION
FACTOR

(Candida
albicans) 		PF00025
(Arf) 		5 GLY A  29
ALA A  27
ILE A  33
VAL A  91
ILE A  89
 GDP  A 500 (-3.2A)
GDP  A 500 (-4.2A)
None
None
None
 0.85A 4aztA-5uf8A:
undetectable		 4aztA-5uf8A:
15.21
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5uow N-METHYL-D-ASPARTATE
RECEPTOR SUBUNIT
NR1-8A

(Xenopus laevis) 		PF00060
(Lig_chan)
PF01094
(ANF_receptor)
PF10613
(Lig_chan-Glu_bd) 		5 GLY A  30
ALA A  62
ILE A  90
VAL A  87
ILE A 116
 None
 1.12A 4aztA-5uowA:
undetectable		 4aztA-5uowA:
20.27
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5wh8 PUTATIVE
CARBOHYDRATE-ACTIVE
ENZYME

(uncultured
organism) 		no annotation 5 GLY A  80
PHE A 110
ILE A 109
VAL A 316
ILE A 152
 None
 1.12A 4aztA-5wh8A:
undetectable		 4aztA-5wh8A:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5wi5 UDP-N-ACETYLGLUCOSAM
INE
1-CARBOXYVINYLTRANSF
ERASE 1

(Streptococcus
pneumoniae) 		PF00275
(EPSP_synthase) 		5 GLY A 384
ALA A 387
ILE A 381
VAL A   6
ILE A   4
 None
 0.99A 4aztA-5wi5A:
undetectable		 4aztA-5wi5A:
22.57
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ys9 ACYL-COENZYME A
OXIDASE 3

(Yarrowia
lipolytica) 		no annotation 5 GLY A 203
ALA A 208
ILE A 259
VAL A 124
ILE A 120
 None
 1.11A 4aztA-5ys9A:
undetectable		 4aztA-5ys9A:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5zqj BETA-XYLOSIDASE

(Bacillus
pumilus) 		no annotation 5 ALA A 406
PHE A 398
ILE A 452
VAL A 459
ILE A 456
 None
 1.06A 4aztA-5zqjA:
undetectable		 4aztA-5zqjA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6bbp CYTOHESIN-3,ADP-RIBO
SYLATION FACTOR 6

(Homo sapiens;
Mus musculus) 		no annotation 5 GLY A 423
ALA A 421
ILE A 427
VAL A 485
ILE A 483
 GTP  A 601 (-3.3A)
GTP  A 601 (-4.2A)
None
None
None
 0.83A 4aztA-6bbpA:
undetectable		 4aztA-6bbpA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6esq HYDROXYMETHYLGLUTARY
L-COA SYNTHASE

(Methanothermococcus
thermolithotrophicus) 		no annotation 6 GLY I 279
ALA I 275
ILE I 283
LEU I 263
VAL I 236
ILE I 293
 None
 1.29A 4aztA-6esqI:
undetectable		 4aztA-6esqI:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6exs PEPTIDE ABC
TRANSPORTER PERMEASE

(Staphylococcus
hominis) 		no annotation 5 GLY A 102
ALA A  98
ASN A 139
ILE A 106
ILE A 129
 None
 0.96A 4aztA-6exsA:
undetectable		 4aztA-6exsA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6fae ADP-RIBOSYLATION
FACTOR 1

(Homo sapiens) 		no annotation 5 GLY B  29
ALA B  27
ILE B  33
VAL B  91
ILE B  89
 None
 0.85A 4aztA-6faeB:
undetectable		 4aztA-6faeB:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1c7o CYSTALYSIN

(Treponema
denticola) 		PF00155
(Aminotran_1_2) 		3 GLN A 220
ASP A 228
GLN A 225
 None
 0.77A 4aztA-1c7oA:
4.6		 4aztA-1c7oA:
18.98
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ko0 DIAMINOPIMELATE
DECARBOXYLASE

(Escherichia
coli) 		PF00278
(Orn_DAP_Arg_deC)
PF02784
(Orn_Arg_deC_N) 		3 GLN A 234
ASP A 374
GLN A 276
 None
 0.75A 4aztA-1ko0A:
0.0		 4aztA-1ko0A:
24.62
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1m5y SURVIVAL PROTEIN
SURA

(Escherichia
coli) 		PF00639
(Rotamase)
PF09312
(SurA_N)
PF13616
(Rotamase_3) 		3 GLN A  69
ASP A 222
GLN A 224
 None
 0.80A 4aztA-1m5yA:
3.1		 4aztA-1m5yA:
20.85
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1m6z CYTOCHROME C4

(Pseudomonas
stutzeri) 		PF00034
(Cytochrom_C) 		3 GLN A 114
ASP A 178
GLN A 102
 None
 0.84A 4aztA-1m6zA:
undetectable		 4aztA-1m6zA:
13.99
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1oah CYTOCHROME C NITRITE
REDUCTASE

(Desulfovibrio
desulfuricans) 		PF02335
(Cytochrom_C552) 		3 GLN A  96
ASP A 423
GLN A 419
 None
 0.86A 4aztA-1oahA:
undetectable		 4aztA-1oahA:
21.03
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ouo NUCLEASE

(Vibrio
vulnificus) 		PF04231
(Endonuclease_1) 		3 GLN A 217
ASP A 210
GLN A 225
 None
 0.84A 4aztA-1ouoA:
undetectable		 4aztA-1ouoA:
16.98
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ulv GLUCODEXTRANASE

(Arthrobacter
globiformis) 		PF00723
(Glyco_hydro_15)
PF09136
(Glucodextran_B)
PF09137
(Glucodextran_N)
PF09985
(Glucodextran_C) 		3 GLN A 336
ASP A 386
GLN A 384
 None
 0.54A 4aztA-1ulvA:
2.5		 4aztA-1ulvA:
21.15
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1uuo DIHYDROOROTATE
DEHYDROGENASE

(Rattus rattus) 		PF01180
(DHO_dh) 		3 GLN A 225
ASP A 264
GLN A 263
 None
 0.70A 4aztA-1uuoA:
1.2		 4aztA-1uuoA:
22.72
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1w85 PYRUVATE
DEHYDROGENASE E1
COMPONENT, ALPHA
SUBUNIT
PYRUVATE
DEHYDROGENASE E1
COMPONENT, BETA
SUBUNIT

(Geobacillus
stearothermophilus;
Geobacillus
stearothermophilus) 		PF00676
(E1_dh)
PF02779
(Transket_pyr)
PF02780
(Transketolase_C) 		3 GLN A 178
ASP B  91
GLN B  96
 TDP  A1370 (-3.9A)
None
None
 0.87A 4aztA-1w85A:
3.4		 4aztA-1w85A:
21.93
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1w9x ALPHA AMYLASE

(Bacillus
halmapalus) 		PF00128
(Alpha-amylase)
PF09154
(DUF1939) 		3 GLN A 319
ASP A 403
GLN A 401
 None
 0.92A 4aztA-1w9xA:
undetectable		 4aztA-1w9xA:
21.15
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1x9s DNA POLYMERASE

(Escherichia
virus T7) 		PF00476
(DNA_pol_A) 		3 GLN A 266
ASP A 340
GLN A 343
 None
 0.78A 4aztA-1x9sA:
undetectable		 4aztA-1x9sA:
22.40
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2aey FRUCTAN
1-EXOHYDROLASE IIA

(Cichorium
intybus) 		PF00251
(Glyco_hydro_32N)
PF08244
(Glyco_hydro_32C) 		3 GLN A  14
ASP A 477
GLN A 364
 None
 0.77A 4aztA-2aeyA:
undetectable		 4aztA-2aeyA:
21.53
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2d3l GLUCAN
1,4-ALPHA-MALTOHEXAO
SIDASE

(Bacillus sp.
707) 		PF00128
(Alpha-amylase)
PF09154
(DUF1939) 		3 GLN A 319
ASP A 403
GLN A 401
 None
 0.85A 4aztA-2d3lA:
undetectable		 4aztA-2d3lA:
22.01
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2die AMYLASE

(Bacillus sp.
(in: Bacteria)) 		PF00128
(Alpha-amylase)
PF09154
(DUF1939) 		3 GLN A 319
ASP A 403
GLN A 401
 None
 0.85A 4aztA-2dieA:
undetectable		 4aztA-2dieA:
20.44
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2fd4 AVIRULENCE PROTEIN
AVRPTOB

(Pseudomonas
syringae) 		PF09046
(AvrPtoB-E3_ubiq) 		3 GLN A 524
ASP A 518
GLN A 491
 None
 0.84A 4aztA-2fd4A:
undetectable		 4aztA-2fd4A:
13.49
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2ffh PROTEIN (FFH)

(Thermus
aquaticus) 		PF00448
(SRP54)
PF02881
(SRP54_N)
PF02978
(SRP_SPB) 		3 GLN A 137
ASP A 195
GLN A 193
 None
 0.84A 4aztA-2ffhA:
2.6		 4aztA-2ffhA:
21.91
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2gsk VITAMIN B12
TRANSPORTER BTUB

(Escherichia
coli) 		PF00593
(TonB_dep_Rec)
PF07715
(Plug) 		3 GLN A  62
ASP A 193
GLN A 191
 None
CA  A   2 ( 2.1A)
None
 0.84A 4aztA-2gskA:
undetectable		 4aztA-2gskA:
22.26
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2j7a CYTOCHROME C NITRITE
REDUCTASE NRFA

(Desulfovibrio
vulgaris) 		PF02335
(Cytochrom_C552) 		3 GLN A  99
ASP A 423
GLN A 419
 None
 0.86A 4aztA-2j7aA:
undetectable		 4aztA-2j7aA:
21.39
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2l6z LIM DOMAIN ONLY 2,
LINKER, LIM
DOMAIN-BINDING
PROTEIN 1

(Mus musculus) 		PF00412
(LIM) 		3 GLN C 126
ASP C 147
GLN C 146
 None
ZN  C 181 (-2.4A)
ZN  C 181 ( 4.9A)
 0.86A 4aztA-2l6zC:
undetectable		 4aztA-2l6zC:
10.87
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2ny0 ENVELOPE
GLYCOPROTEIN GP120

(Human
immunodeficiency
virus 1) 		PF00516
(GP120) 		3 GLN A 203
ASP A 113
GLN A 428
 None
 0.89A 4aztA-2ny0A:
undetectable		 4aztA-2ny0A:
17.46
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2p8j S-ADENOSYLMETHIONINE
-DEPENDENT
METHYLTRANSFERASE

(Clostridium
acetobutylicum) 		PF08241
(Methyltransf_11) 		3 GLN A 148
ASP A 132
GLN A 193
 None
 0.89A 4aztA-2p8jA:
13.2		 4aztA-2p8jA:
16.05
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2qqu BETA-FRUCTOFURANOSID
ASE

(Arabidopsis
thaliana) 		PF00251
(Glyco_hydro_32N)
PF08244
(Glyco_hydro_32C) 		3 GLN A  15
ASP A 484
GLN A 370
 None
 0.85A 4aztA-2qquA:
undetectable		 4aztA-2qquA:
22.15
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2vph TYROSINE-PROTEIN
PHOSPHATASE
NON-RECEPTOR TYPE 4

(Homo sapiens) 		PF00595
(PDZ) 		3 GLN A 581
ASP A 537
GLN A 538
 None
 0.90A 4aztA-2vphA:
undetectable		 4aztA-2vphA:
11.83
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2vz9 FATTY ACID SYNTHASE

(Sus scrofa) 		PF00107
(ADH_zinc_N)
PF00109
(ketoacyl-synt)
PF00698
(Acyl_transf_1)
PF02801
(Ketoacyl-synt_C)
PF08242
(Methyltransf_12)
PF08659
(KR)
PF14765
(PS-DH)
PF16197
(KAsynt_C_assoc) 		3 GLN A 259
ASP A 254
GLN A 269
 None
 0.91A 4aztA-2vz9A:
undetectable		 4aztA-2vz9A:
12.99
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2xyb LACCASE

(Trametes
cinnabarina) 		PF00394
(Cu-oxidase)
PF07731
(Cu-oxidase_2)
PF07732
(Cu-oxidase_3) 		3 GLN A  98
ASP A 101
GLN A 102
 None
 0.84A 4aztA-2xybA:
undetectable		 4aztA-2xybA:
22.31
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2y0k PYROGLUTATMATE PORIN
OPDO

(Pseudomonas
aeruginosa) 		PF03573
(OprD) 		3 GLN A  86
ASP A 159
GLN A 161
 None
 0.43A 4aztA-2y0kA:
undetectable		 4aztA-2y0kA:
22.07
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2y4f PEROXIDASE YCDB

(Escherichia
coli) 		PF04261
(Dyp_perox) 		3 GLN A 214
ASP A 222
GLN A 223
 None
 0.84A 4aztA-2y4fA:
undetectable		 4aztA-2y4fA:
21.16
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2yha POST-TRANSCRIPTIONAL
GENE SILENCING
PROTEIN QDE-2

(Neurospora
crassa) 		PF02171
(Piwi) 		3 GLN A 753
ASP A 758
GLN A 708
 None
 0.92A 4aztA-2yhaA:
undetectable		 4aztA-2yhaA:
21.28
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2yn9 POTASSIUM-TRANSPORTI
NG ATPASE ALPHA
CHAIN 1

(Sus scrofa) 		PF00122
(E1-E2_ATPase)
PF00689
(Cation_ATPase_C)
PF00690
(Cation_ATPase_N)
PF09040
(H-K_ATPase_N)
PF13246
(Cation_ATPase) 		3 GLN A 923
ASP A 909
GLN A 913
 None
 0.93A 4aztA-2yn9A:
undetectable		 4aztA-2yn9A:
20.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2zb9 PUTATIVE
TRANSCRIPTIONAL
REGULATOR

(Streptomyces
coelicolor) 		PF00440
(TetR_N)
PF16859
(TetR_C_11) 		3 GLN A 169
ASP A 162
GLN A 164
 None
 0.87A 4aztA-2zb9A:
undetectable		 4aztA-2zb9A:
18.12
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3bbl REGULATORY PROTEIN
OF LACI FAMILY

(Chloroflexus
aggregans) 		PF13377
(Peripla_BP_3) 		3 GLN A  84
ASP A 284
GLN A 289
 None
 0.88A 4aztA-3bblA:
undetectable		 4aztA-3bblA:
18.38
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3c2u XYLOSIDASE/ARABINOSI
DASE

(Selenomonas
ruminantium) 		PF04616
(Glyco_hydro_43)
PF07081
(DUF1349) 		3 GLN A 300
ASP A 229
GLN A 227
 None
 0.91A 4aztA-3c2uA:
undetectable		 4aztA-3c2uA:
21.99
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3e48 PUTATIVE
NUCLEOSIDE-DIPHOSPHA
TE-SUGAR EPIMERASE

(Staphylococcus
aureus) 		PF13460
(NAD_binding_10) 		3 GLN A  19
ASP A 176
GLN A 271
 None
 0.72A 4aztA-3e48A:
undetectable		 4aztA-3e48A:
19.61
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3e82 PUTATIVE
OXIDOREDUCTASE

(Klebsiella
pneumoniae) 		PF01408
(GFO_IDH_MocA)
PF02894
(GFO_IDH_MocA_C) 		3 GLN A 195
ASP A 264
GLN A 266
 None
 0.92A 4aztA-3e82A:
3.6		 4aztA-3e82A:
22.01
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3f2b DNA-DIRECTED DNA
POLYMERASE III ALPHA
CHAIN

(Geobacillus
kaustophilus) 		PF02811
(PHP)
PF07733
(DNA_pol3_alpha)
PF14579
(HHH_6) 		3 GLN A 353
ASP A1074
GLN A1070
 None
 0.90A 4aztA-3f2bA:
undetectable		 4aztA-3f2bA:
20.83
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3gp6 PROTEIN PAGP

(Escherichia
coli) 		PF07017
(PagP) 		3 GLN A 139
ASP A  24
GLN A 160
 SDS  A 163 ( 3.9A)
None
None
 0.89A 4aztA-3gp6A:
undetectable		 4aztA-3gp6A:
14.46
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3guz PANTOTHENATE
SYNTHETASE

(Escherichia
coli) 		PF02569
(Pantoate_ligase) 		3 GLN A  61
ASP A 152
GLN A 154
 PAF  A 177 (-3.1A)
None
None
 0.87A 4aztA-3guzA:
undetectable		 4aztA-3guzA:
16.34
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3iv0 SUSD HOMOLOG

(Bacteroides
thetaiotaomicron) 		PF07980
(SusD_RagB)
PF14322
(SusD-like_3) 		3 GLN A  62
ASP A 115
GLN A 113
 None
 0.89A 4aztA-3iv0A:
undetectable		 4aztA-3iv0A:
22.18
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3jwe MGLL PROTEIN

(Homo sapiens) 		PF12146
(Hydrolase_4) 		3 GLN A  38
ASP A 109
GLN A 112
 None
 0.88A 4aztA-3jweA:
undetectable		 4aztA-3jweA:
21.39
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3kg6 CURF

(Lyngbya
majuscula) 		PF14765
(PS-DH) 		3 GLN A1819
ASP A1949
GLN A1951
 None
 0.84A 4aztA-3kg6A:
undetectable		 4aztA-3kg6A:
18.45
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3kvn ESTERASE ESTA

(Pseudomonas
aeruginosa) 		no annotation 3 GLN X 539
ASP X 337
GLN X 333
 None
 0.89A 4aztA-3kvnX:
undetectable		 4aztA-3kvnX:
24.52
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3kzq PUTATIVE
UNCHARACTERIZED
PROTEIN VP2116

(Vibrio
parahaemolyticus) 		PF13743
(Thioredoxin_5) 		3 GLN A 156
ASP A  46
GLN A  90
 None
 0.79A 4aztA-3kzqA:
undetectable		 4aztA-3kzqA:
15.89
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3kzw CYTOSOL
AMINOPEPTIDASE

(Staphylococcus
aureus) 		PF00883
(Peptidase_M17)
PF02789
(Peptidase_M17_N) 		3 GLN A 486
ASP A 122
GLN A 119
 None
 0.93A 4aztA-3kzwA:
undetectable		 4aztA-3kzwA:
24.26
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3mve UPF0255 PROTEIN
VV1_0328

(Vibrio
vulnificus) 		PF06500
(DUF1100) 		3 GLN A  34
ASP A  83
GLN A  85
 None
 0.82A 4aztA-3mveA:
undetectable		 4aztA-3mveA:
21.90
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3pxl LACCASE

(Trametes
hirsuta) 		PF00394
(Cu-oxidase)
PF07731
(Cu-oxidase_2)
PF07732
(Cu-oxidase_3) 		3 GLN A  98
ASP A 101
GLN A 102
 None
 0.80A 4aztA-3pxlA:
undetectable		 4aztA-3pxlA:
22.15
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3tgq HIV-1 YU2 GP120

(Human
immunodeficiency
virus 1) 		PF00516
(GP120) 		3 GLN A 203
ASP A 113
GLN A 428
 None
 0.80A 4aztA-3tgqA:
undetectable		 4aztA-3tgqA:
17.01
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3to3 PETROBACTIN
BIOSYNTHESIS PROTEIN
ASBB

(Bacillus
anthracis) 		PF04183
(IucA_IucC)
PF06276
(FhuF) 		3 GLN A  27
ASP A 129
GLN A 133
 None
 0.86A 4aztA-3to3A:
4.5		 4aztA-3to3A:
21.97
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3to3 PETROBACTIN
BIOSYNTHESIS PROTEIN
ASBB

(Bacillus
anthracis) 		PF04183
(IucA_IucC)
PF06276
(FhuF) 		3 GLN A  27
ASP A 156
GLN A 133
 None
 0.89A 4aztA-3to3A:
4.5		 4aztA-3to3A:
21.97
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ttl POLYAMINE TRANSPORT
PROTEIN

(Pseudomonas
aeruginosa) 		PF13416
(SBP_bac_8) 		3 GLN A 116
ASP A 338
GLN A 334
 None
 0.76A 4aztA-3ttlA:
undetectable		 4aztA-3ttlA:
19.82
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3u4v TELOMERASE-ASSOCIATE
D PROTEIN 82

(Tetrahymena
thermophila) 		PF01336
(tRNA_anti-codon) 		3 GLN A 218
ASP A 256
GLN A 260
 None
 0.86A 4aztA-3u4vA:
undetectable		 4aztA-3u4vA:
13.24
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3v6a APOPTOSIS INHIBITOR
5

(Homo sapiens) 		PF05918
(API5) 		3 GLN A 142
ASP A 100
GLN A 104
 None
 0.86A 4aztA-3v6aA:
undetectable		 4aztA-3v6aA:
23.68
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3w3a V-TYPE ATP SYNTHASE
BETA CHAIN

(Thermus
thermophilus) 		PF00006
(ATP-synt_ab)
PF02874
(ATP-synt_ab_N) 		3 GLN D 425
ASP D 139
GLN D 132
 None
 0.83A 4aztA-3w3aD:
2.2		 4aztA-3w3aD:
22.26
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3wxr PROTEASOME SUBUNIT
BETA TYPE-4

(Saccharomyces
cerevisiae) 		PF00227
(Proteasome) 		3 GLN K 190
ASP K 193
GLN K 197
 None
 0.78A 4aztA-3wxrK:
undetectable		 4aztA-3wxrK:
17.02
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3zn6 VP17
VP16

(Thermus virus
P23-77;
Thermus virus
P23-77) 		no annotation
no annotation 		3 GLN B  68
ASP B 100
GLN A 126
 None
 0.86A 4aztA-3zn6B:
undetectable		 4aztA-3zn6B:
14.64
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ac1 ENDO-N-ACETYL-BETA-D
-GLUCOSAMINIDASE

(Trichoderma
reesei) 		PF00704
(Glyco_hydro_18) 		3 GLN X 132
ASP X 129
GLN X 193
 None
ACT  X1288 (-2.9A)
ZN  X1294 ( 2.5A)
 0.86A 4aztA-4ac1X:
undetectable		 4aztA-4ac1X:
18.74
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4azv WBDD

(Escherichia
coli) 		PF00069
(Pkinase)
PF13847
(Methyltransf_31) 		3 GLN A  17
ASP A  82
GLN A  84
 SAM  A1474 (-3.5A)
SAM  A1474 (-1.7A)
SAM  A1474 (-3.9A)
 0.09A 4aztA-4azvA:
55.9		 4aztA-4azvA:
100.00
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4azw WBDD

(Escherichia
coli) 		PF00069
(Pkinase)
PF13847
(Methyltransf_31) 		3 GLN A  17
ASP A  82
GLN A  84
 SAM  A1451 (-3.9A)
SAM  A1451 (-2.7A)
SAM  A1451 (-4.2A)
 0.27A 4aztA-4azwA:
49.6		 4aztA-4azwA:
99.36
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ev1 ANABENA TIC22

(Anabaena sp.) 		PF04278
(Tic22) 		3 GLN A 174
ASP A 213
GLN A 215
 None
None
NHE  A 302 (-3.1A)
 0.93A 4aztA-4ev1A:
undetectable		 4aztA-4ev1A:
19.14
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4f4f THREONINE SYNTHASE

(Brucella
melitensis) 		PF00291
(PALP)
PF14821
(Thr_synth_N) 		3 GLN A 176
ASP A 113
GLN A 117
 None
 0.93A 4aztA-4f4fA:
2.8		 4aztA-4f4fA:
22.36
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4gnr ABC TRANSPORTER
SUBSTRATE-BINDING
PROTEIN-BRANCHED
CHAIN AMINO ACID
TRANSPORT

(Streptococcus
pneumoniae) 		PF13458
(Peripla_BP_6) 		3 GLN A  81
ASP A  69
GLN A  65
 None
 0.78A 4aztA-4gnrA:
2.0		 4aztA-4gnrA:
20.57
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4h32 HEMAGGLUTININ
HEMAGGLUTININ

(Influenza A
virus;
Influenza A
virus) 		PF00509
(Hemagglutinin)
PF00509
(Hemagglutinin) 		3 GLN A 298
ASP B 410
GLN B 406
 None
 0.84A 4aztA-4h32A:
undetectable		 4aztA-4h32A:
19.51
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4igg CATENIN ALPHA-1

(Homo sapiens) 		PF01044
(Vinculin) 		3 GLN A 206
ASP A 200
GLN A 271
 None
 0.69A 4aztA-4iggA:
undetectable		 4aztA-4iggA:
20.94
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4jm2 GP120

(Human
immunodeficiency
virus 1) 		PF00516
(GP120) 		3 GLN E 203
ASP E 113
GLN E 428
 None
 0.90A 4aztA-4jm2E:
undetectable		 4aztA-4jm2E:
18.80
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4lry PTS-DEPENDENT
DIHYDROXYACETONE
KINASE,
DIHYDROXYACETONE-BIN
DING SUBUNIT DHAK

(Escherichia
coli) 		PF02733
(Dak1) 		3 GLN A 183
ASP A 276
GLN A 273
 None
 0.93A 4aztA-4lryA:
undetectable		 4aztA-4lryA:
20.83
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4m5p NADPH DEHYDROGENASE

(Scheffersomyces
stipitis) 		PF00724
(Oxidored_FMN) 		3 GLN A 248
ASP A 196
GLN A 200
 None
 0.90A 4aztA-4m5pA:
undetectable		 4aztA-4m5pA:
23.29
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4mmo SSO-CP2
METALLO-CARBOXYPETID
ASE

(Sulfolobus
solfataricus) 		PF01546
(Peptidase_M20)
PF07687
(M20_dimer) 		3 GLN A 381
ASP A 104
GLN A  75
 None
ZN  A 501 (-2.5A)
None
 0.75A 4aztA-4mmoA:
undetectable		 4aztA-4mmoA:
22.58
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4n75 OUTER MEMBRANE
PROTEIN ASSEMBLY
FACTOR BAMA

(Escherichia
coli) 		PF01103
(Bac_surface_Ag) 		3 GLN A 561
ASP A 497
GLN A 495
 None
 0.54A 4aztA-4n75A:
undetectable		 4aztA-4n75A:
19.50
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4opf NRPS/PKS

(Streptomyces
albus) 		PF00109
(ketoacyl-synt)
PF02801
(Ketoacyl-synt_C) 		3 GLN A6250
ASP A6192
GLN A6194
 None
 0.90A 4aztA-4opfA:
undetectable		 4aztA-4opfA:
21.90
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4q6k BNR/ASP-BOX REPEAT
PROTEIN

(Bacteroides
caccae) 		PF13088
(BNR_2)
PF14873
(BNR_assoc_N) 		3 GLN A 330
ASP A 351
GLN A 352
 None
 0.89A 4aztA-4q6kA:
undetectable		 4aztA-4q6kA:
21.52
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4r4n HIV-1 GP120

(Human
immunodeficiency
virus 1) 		PF00516
(GP120) 		3 GLN A 203
ASP A 113
GLN A 428
 None
 0.84A 4aztA-4r4nA:
undetectable		 4aztA-4r4nA:
19.38
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ye4 HT593.1 GP120

(Human
immunodeficiency
virus) 		PF00516
(GP120) 		3 GLN G 203
ASP G 113
GLN G 428
 None
 0.84A 4aztA-4ye4G:
undetectable		 4aztA-4ye4G:
16.64
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4yn0 AMYLOID BETA A4
PROTEIN

(Mus musculus) 		PF12925
(APP_E2) 		3 GLN B 492
ASP B 485
GLN B 484
 None
 0.91A 4aztA-4yn0B:
undetectable		 4aztA-4yn0B:
18.10
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ahk ACETOLACTATE
SYNTHASE II, LARGE
SUBUNIT

(Pseudomonas
protegens) 		PF00205
(TPP_enzyme_M)
PF02775
(TPP_enzyme_C)
PF02776
(TPP_enzyme_N) 		3 GLN A 313
ASP A 287
GLN A 290
 FAD  A 701 (-3.8A)
FAD  A 701 (-3.2A)
FAD  A 701 (-3.8A)
 0.92A 4aztA-5ahkA:
undetectable		 4aztA-5ahkA:
21.88
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5cfa BONE
SIALOPROTEIN-BINDING
PROTEIN

(Staphylococcus
aureus) 		PF10425
(SdrG_C_C) 		3 GLN A 149
ASP A  30
GLN A  27
 None
 0.85A 4aztA-5cfaA:
undetectable		 4aztA-5cfaA:
19.93
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5diz PROTEINACEOUS RNASE
P 2

(Arabidopsis
thaliana) 		PF16953
(PRORP)
PF17177
(PPR_long) 		3 GLN A 329
ASP A 303
GLN A 299
 None
 0.77A 4aztA-5dizA:
undetectable		 4aztA-5dizA:
23.06
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5dll AMINOPEPTIDASE N

(Francisella
tularensis) 		PF01433
(Peptidase_M1)
PF11940
(DUF3458)
PF17432
(DUF3458_C) 		3 GLN A 707
ASP A 699
GLN A 695
 None
 0.89A 4aztA-5dllA:
undetectable		 4aztA-5dllA:
20.67
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5dxi TREHALOSE-6-PHOSPHAT
E PHOSPHATASE

(Candida
albicans) 		PF02358
(Trehalose_PPase) 		3 GLN A  60
ASP A  93
GLN A 204
 None
 0.61A 4aztA-5dxiA:
2.9		 4aztA-5dxiA:
19.26
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5f2v GTP
PYROPHOSPHOKINASE
YJBM

(Bacillus
subtilis) 		no annotation 3 GLN V 195
ASP V  85
GLN V  81
 None
 0.81A 4aztA-5f2vV:
undetectable		 4aztA-5f2vV:
16.97
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5fhx ANTIBODY FRAGMENT
HEAVY-CHAIN
ANTIBODY FRAGMENT
LIGHT CHAIN

(Homo sapiens;
Homo sapiens) 		PF07654
(C1-set)
PF07686
(V-set)
PF07654
(C1-set)
PF07686
(V-set) 		3 GLN H  65
ASP L  86
GLN L  83
 None
 0.93A 4aztA-5fhxH:
undetectable		 4aztA-5fhxH:
19.66
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5g5z ABC TRANSPORTER,
SUBSTRATE-BINDING
PROTEIN

(Streptococcus
pneumoniae) 		PF01547
(SBP_bac_1) 		3 GLN A  70
ASP A 389
GLN A 392
 None
 0.90A 4aztA-5g5zA:
undetectable		 4aztA-5g5zA:
21.94
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5gjv VOLTAGE-DEPENDENT
L-TYPE CALCIUM
CHANNEL SUBUNIT
ALPHA-1S
VOLTAGE-DEPENDENT
L-TYPE CALCIUM
CHANNEL SUBUNIT
BETA-1

(Oryctolagus
cuniculus;
Oryctolagus
cuniculus) 		PF00520
(Ion_trans)
PF08763
(Ca_chan_IQ)
PF16905
(GPHH)
PF00625
(Guanylate_kin) 		3 GLN C 438
ASP A 362
GLN A 358
 None
 0.91A 4aztA-5gjvC:
undetectable		 4aztA-5gjvC:
16.64
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5gly GLYCOSIDE HYDROLASE
FAMILY 45 PROTEIN

(Thielavia
terrestris) 		PF02015
(Glyco_hydro_45) 		3 GLN A  38
ASP A  59
GLN A  60
 None
 0.74A 4aztA-5glyA:
undetectable		 4aztA-5glyA:
15.56
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5gw5 T-COMPLEX PROTEIN 1
SUBUNIT ETA

(Saccharomyces
cerevisiae) 		PF00118
(Cpn60_TCP1) 		3 GLN h 232
ASP h 309
GLN h 305
 None
 0.92A 4aztA-5gw5h:
undetectable		 4aztA-5gw5h:
25.30
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5h64 SERINE/THREONINE-PRO
TEIN KINASE MTOR

(Homo sapiens) 		PF00454
(PI3_PI4_kinase)
PF02259
(FAT)
PF02260
(FATC)
PF08771
(FRB_dom)
PF11865
(DUF3385) 		3 GLN A 908
ASP A1565
GLN A1561
 None
 0.87A 4aztA-5h64A:
3.8		 4aztA-5h64A:
12.64
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ihz 1E01 FAB FRAGMENT
LIGHT CHAIN

(Homo sapiens) 		PF07654
(C1-set)
PF07686
(V-set) 		3 GLN B  45
ASP B  98
GLN B  95
 None
 0.92A 4aztA-5ihzB:
undetectable		 4aztA-5ihzB:
17.59
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5iy9 GENERAL
TRANSCRIPTION FACTOR
IIH SUBUNIT 4

(Homo sapiens) 		PF03849
(Tfb2) 		3 GLN 2 181
ASP 2 174
GLN 2 173
 None
 0.81A 4aztA-5iy92:
undetectable		 4aztA-5iy92:
23.28
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5iy9 GENERAL
TRANSCRIPTION FACTOR
IIH SUBUNIT 4

(Homo sapiens) 		PF03849
(Tfb2) 		3 GLN 2 239
ASP 2 207
GLN 2 202
 None
 0.73A 4aztA-5iy92:
undetectable		 4aztA-5iy92:
23.28
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5meb CELL DIVISION CYCLE
PROTEIN CDT1

(Saccharomyces
cerevisiae) 		PF16679
(CDT1_C) 		3 GLN A 596
ASP A 604
GLN A 603
 None
 0.89A 4aztA-5mebA:
undetectable		 4aztA-5mebA:
14.49
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5mua RICIN B-RELATED
LECTIN

(Polyporus
squamosus) 		PF14200
(RicinB_lectin_2) 		3 GLN A 147
ASP A  43
GLN A 186
 None
 0.89A 4aztA-5muaA:
undetectable		 4aztA-5muaA:
19.01
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5my0 FATTY ACID SYNTHASE

(Mus musculus) 		no annotation 3 GLN B 259
ASP B 254
GLN B 269
 None
 0.88A 4aztA-5my0B:
undetectable		 4aztA-5my0B:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5svc ACETONE CARBOXYLASE
ALPHA SUBUNIT

(Xanthobacter
autotrophicus) 		PF02538
(Hydantoinase_B) 		3 GLN A 668
ASP A 641
GLN A 637
 None
 0.76A 4aztA-5svcA:
undetectable		 4aztA-5svcA:
20.90
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5v54 5-HYDROXYTRYPTAMINE
RECEPTOR 1B,OB-1
FUSED 5-HT1B
RECEPTOR,5-HYDROXYTR
YPTAMINE RECEPTOR 1B

(Spodoptera
frugiperda;
Homo sapiens) 		no annotation 3 GLN A 189
ASP A 123
GLN A 119
 None
 0.90A 4aztA-5v54A:
undetectable		 4aztA-5v54A:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5vpr CYSTEINE DESULFURASE

(Elizabethkingia
anophelis) 		PF00266
(Aminotran_5) 		3 GLN A  10
ASP A   3
GLN A   5
 None
 0.84A 4aztA-5vprA:
undetectable		 4aztA-5vprA:
22.72
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5xfm ALPHA-GLUCOSIDASE

(Bacteroides
thetaiotaomicron) 		no annotation 3 GLN A 640
ASP A 473
GLN A 469
 None
 0.91A 4aztA-5xfmA:
undetectable		 4aztA-5xfmA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5y7o UGGT

(Thermomyces
dupontii) 		PF06427
(UDP-g_GGTase) 		3 GLN A 567
ASP A 553
GLN A 549
 None
 0.81A 4aztA-5y7oA:
undetectable		 4aztA-5y7oA:
19.34
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5yo8 TETRAPRENYL-BETA-CUR
CUMENE SYNTHASE

(Bacillus
alcalophilus) 		no annotation 3 GLN A 170
ASP A  85
GLN A  81
 None
 0.91A 4aztA-5yo8A:
undetectable		 4aztA-5yo8A:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6c3p ATP-BINDING CASSETTE
SUB-FAMILY C MEMBER
8

(Homo sapiens) 		no annotation 3 GLN E1483
ASP E1427
GLN E1426
 None
 0.76A 4aztA-6c3pE:
undetectable		 4aztA-6c3pE:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6ch3 FLAGELLAR
BIOSYNTHESIS PROTEIN
FLHA
FLAGELLAR SECRETION
CHAPERONE
FLIS,FLAGELLIN

(Salmonella
enterica;
Salmonella
enterica) 		no annotation
no annotation 		3 GLN B  12
ASP A 397
GLN A 396
 None
 0.78A 4aztA-6ch3B:
undetectable		 4aztA-6ch3B:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6ez8 HUNTINGTIN

(Homo sapiens) 		no annotation 3 GLN A2555
ASP A2574
GLN A2525
 None
 0.91A 4aztA-6ez8A:
undetectable		 4aztA-6ez8A:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6fos PHOTOSYSTEM I P700
CHLOROPHYLL A
APOPROTEIN A2

(Cyanidioschyzon
merolae) 		no annotation 3 GLN D  79
ASP D  99
GLN D  93
 None
 0.87A 4aztA-6fosD:
undetectable		 4aztA-6fosD:
undetectable