SIMILAR PATTERNS OF AMINO ACIDS FOR 4AX8_A_SAMA1474_1

List of similar pattern of amino acids derived from ASSAM search

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click link on the last column to view superposed patterns of amino acids in NGL viewer)
(Note that only 3-12 residue patterns can be used for ASSAM searches)
Filter list by:
Hit Macromolecule/
Organism		 Pfam Res. Interface HETATM RMSD Dali Z-score Seq. Identity (%) View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1d9s CYCLIN-DEPENDENT
KINASE 4 INHIBITOR B

(Mus musculus) 		PF12796
(Ank_2) 		4 ARG A  23
ASP A  86
GLU A  82
LEU A  56
 None
 1.24A 4ax8A-1d9sA:
0.0		 4ax8A-1d9sA:
15.32
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1e5i DEACETOXYCEPHALOSPOR
IN C SYNTHASE

(Streptomyces
clavuligerus) 		PF03171
(2OG-FeII_Oxy) 		4 ARG A 266
ASP A 107
GLU A 116
LEU A 158
 None
 1.19A 4ax8A-1e5iA:
0.0		 4ax8A-1e5iA:
18.37
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1fbv SIGNAL TRANSDUCTION
PROTEIN CBL

(Homo sapiens) 		PF02262
(Cbl_N)
PF02761
(Cbl_N2)
PF02762
(Cbl_N3)
PF14447
(Prok-RING_4) 		4 GLN A 316
ASP A 275
GLU A 143
LEU A 281
 None
 1.29A 4ax8A-1fbvA:
0.0		 4ax8A-1fbvA:
21.88
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1h31 DIHEME CYTOCHROME C

(Rhodovulum
sulfidophilum) 		no annotation 4 GLN A 196
ARG A 248
ASP A  29
LEU A  24
 None
 1.40A 4ax8A-1h31A:
0.0		 4ax8A-1h31A:
19.04
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1h6d PRECURSOR FORM OF
GLUCOSE-FRUCTOSE
OXIDOREDUCTASE

(Zymomonas
mobilis) 		PF01408
(GFO_IDH_MocA)
PF02894
(GFO_IDH_MocA_C) 		4 TYR A 412
GLN A 409
ARG A 255
GLU A 180
 None
None
None
NDP  A 500 (-3.2A)
 1.28A 4ax8A-1h6dA:
4.0		 4ax8A-1h6dA:
21.86
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1irx LYSYL-TRNA
SYNTHETASE

(Pyrococcus
horikoshii) 		PF01921
(tRNA-synt_1f) 		4 TYR A 424
ASP A 318
GLU A 329
LEU A 293
 None
 1.40A 4ax8A-1irxA:
2.6		 4ax8A-1irxA:
21.07
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1mio NITROGENASE
MOLYBDENUM IRON
PROTEIN (BETA CHAIN)

(Clostridium
pasteurianum) 		PF00148
(Oxidored_nitro) 		4 ARG B 189
ASP B 274
GLU B 282
LEU B 190
 None
 1.23A 4ax8A-1mioB:
0.6		 4ax8A-1mioB:
21.81
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1n21 (+)-BORNYL
DIPHOSPHATE SYNTHASE

(Salvia
officinalis) 		PF01397
(Terpene_synth)
PF03936
(Terpene_synth_C) 		4 GLN A 254
ASP A 120
GLU A 125
LEU A 116
 None
 1.10A 4ax8A-1n21A:
0.0		 4ax8A-1n21A:
22.35
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1qgr PROTEIN (IMPORTIN
BETA SUBUNIT)
PROTEIN (IMPORTIN
ALPHA-2 SUBUNIT)

(Homo sapiens;
Homo sapiens) 		PF03810
(IBN_N)
PF13513
(HEAT_EZ)
PF01749
(IBB) 		4 GLN A 589
ARG A 593
GLU A 760
LEU B  38
 None
 1.17A 4ax8A-1qgrA:
0.6		 4ax8A-1qgrA:
20.56
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1r4n AMYLOID BETA
PRECURSOR
PROTEIN-BINDING
PROTEIN 1

(Homo sapiens) 		PF00899
(ThiF) 		4 GLN A 343
ASP A 331
GLU A 263
LEU A 342
 None
 1.33A 4ax8A-1r4nA:
5.9		 4ax8A-1r4nA:
22.19
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1wao SERINE/THREONINE
PROTEIN PHOSPHATASE
5

(Homo sapiens) 		PF00149
(Metallophos)
PF00515
(TPR_1)
PF08321
(PPP5) 		4 TYR 1  78
ARG 1 275
ASP 1 388
GLU 1 435
 None
MN  1 602 ( 4.7A)
None
None
 1.37A 4ax8A-1wao1:
undetectable		 4ax8A-1wao1:
22.15
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1woy METHIONYL-TRNA
SYNTHETASE

(Thermus
thermophilus) 		PF00133
(tRNA-synt_1)
PF09334
(tRNA-synt_1g) 		4 TYR A  24
ASP A 260
GLU A 189
LEU A 256
 None
 1.37A 4ax8A-1woyA:
undetectable		 4ax8A-1woyA:
22.59
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1wz2 LEUCYL-TRNA
SYNTHETASE

(Pyrococcus
horikoshii) 		PF00133
(tRNA-synt_1)
PF08264
(Anticodon_1) 		4 GLN A 276
ARG A 256
ASP A 208
GLU A 425
 None
 1.11A 4ax8A-1wz2A:
undetectable		 4ax8A-1wz2A:
19.34
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1xrs D-LYSINE
5,6-AMINOMUTASE
ALPHA SUBUNIT

(Acetoanaerobium
sticklandii) 		PF09043
(Lys-AminoMut_A) 		4 TYR A 230
ARG A 217
ASP A 178
LEU A 233
 None
 1.14A 4ax8A-1xrsA:
undetectable		 4ax8A-1xrsA:
21.80
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1yxa SERINE (OR CYSTEINE)
PROTEINASE
INHIBITOR, CLADE A,
MEMBER 3N

(Mus musculus) 		PF00079
(Serpin) 		4 GLN A 169
ARG A 144
ASP A 198
GLU A 323
 None
 1.41A 4ax8A-1yxaA:
undetectable		 4ax8A-1yxaA:
23.08
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1zj9 PROBABLE
FERREDOXIN-DEPENDENT
NITRITE REDUCTASE
NIRA

(Mycobacterium
tuberculosis) 		PF01077
(NIR_SIR)
PF03460
(NIR_SIR_ferr) 		4 ARG A 433
ASP A 526
GLU A 446
LEU A 437
 None
 1.28A 4ax8A-1zj9A:
undetectable		 4ax8A-1zj9A:
23.48
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1zjj HYPOTHETICAL PROTEIN
PH1952

(Pyrococcus
horikoshii) 		PF13242
(Hydrolase_like)
PF13344
(Hydrolase_6) 		4 ARG A 112
ASP A 129
GLU A  92
LEU A 108
 None
 1.26A 4ax8A-1zjjA:
2.5		 4ax8A-1zjjA:
18.45
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2bb3 COBALAMIN
BIOSYNTHESIS
PRECORRIN-6Y
METHYLASE (CBIE)

(Archaeoglobus
fulgidus) 		PF00590
(TP_methylase) 		4 ARG A 173
ASP A 178
GLU A 194
LEU A 161
 None
 1.42A 4ax8A-2bb3A:
undetectable		 4ax8A-2bb3A:
19.48
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2cly ATP SYNTHASE B
CHAIN, MITOCHONDRIAL
ATP SYNTHASE D
CHAIN, MITOCHONDRIAL

(Bos taurus;
Bos taurus) 		PF05405
(Mt_ATP-synt_B)
PF05873
(Mt_ATP-synt_D) 		4 GLN B  23
ARG A 121
GLU B  35
LEU A 124
 None
 1.19A 4ax8A-2clyB:
undetectable		 4ax8A-2clyB:
14.26
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2dkk CYTOCHROME P450

(Streptomyces
coelicolor) 		PF00067
(p450) 		4 ARG A 363
ASP A 340
GLU A 265
LEU A 281
 None
 1.23A 4ax8A-2dkkA:
undetectable		 4ax8A-2dkkA:
22.42
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2fd5 TRANSCRIPTIONAL
REGULATOR

(Pseudomonas
aeruginosa) 		PF00440
(TetR_N) 		4 GLN A  18
ASP A 101
GLU A  72
LEU A  62
 None
 1.27A 4ax8A-2fd5A:
undetectable		 4ax8A-2fd5A:
17.31
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2gdu SUCROSE
PHOSPHORYLASE

(Bifidobacterium
adolescentis) 		PF00128
(Alpha-amylase)
PF09244
(DUF1964) 		4 TYR A 109
ARG A 150
ASP A 164
GLU A 200
 None
 1.24A 4ax8A-2gduA:
undetectable		 4ax8A-2gduA:
21.97
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2ihy ABC TRANSPORTER,
ATP-BINDING PROTEIN

(Staphylococcus
aureus) 		PF00005
(ABC_tran) 		4 ARG A 253
ASP A 174
GLU A 147
LEU A 182
 None
 1.24A 4ax8A-2ihyA:
undetectable		 4ax8A-2ihyA:
19.83
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2o8r POLYPHOSPHATE KINASE

(Porphyromonas
gingivalis) 		PF02503
(PP_kinase)
PF13089
(PP_kinase_N)
PF13090
(PP_kinase_C) 		4 TYR A  97
ASP A 102
GLU A 109
LEU A  40
 SO4  A 705 (-4.5A)
None
None
None
 1.27A 4ax8A-2o8rA:
undetectable		 4ax8A-2o8rA:
22.24
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2qyk CYCLIC AMP-SPECIFIC
PHOSPHODIESTERASE
HSPDE4A10

(Homo sapiens) 		PF00233
(PDEase_I) 		4 TYR A 435
ASP A 415
GLU A 455
LEU A 446
 None
 1.21A 4ax8A-2qykA:
undetectable		 4ax8A-2qykA:
22.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2w49 TROPONIN C, SKELETAL
MUSCLE

(Gallus gallus) 		PF13499
(EF-hand_7)
PF13833
(EF-hand_8) 		4 ARG 0  10
ASP 0  26
GLU 0  40
LEU 0  78
 None
None
CA  01003 (-2.3A)
None
 1.35A 4ax8A-2w490:
undetectable		 4ax8A-2w490:
14.29
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2zts PUTATIVE
UNCHARACTERIZED
PROTEIN PH0186

(Pyrococcus
horikoshii) 		PF06745
(ATPase) 		4 ARG A 150
ASP A  73
GLU A  89
LEU A  67
 None
 1.35A 4ax8A-2ztsA:
3.8		 4ax8A-2ztsA:
18.10
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3bdq STEROL CARRIER
PROTEIN 2-LIKE 2

(Aedes aegypti) 		PF02036
(SCP2) 		4 GLN A  48
ASP A  52
GLU A   8
LEU A  49
 None
 1.22A 4ax8A-3bdqA:
undetectable		 4ax8A-3bdqA:
11.25
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3c8z CYSTEINYL-TRNA
SYNTHETASE

(Mycolicibacterium
smegmatis) 		PF01406
(tRNA-synt_1e) 		4 GLN A 200
ARG A 178
ASP A 191
LEU A 201
 None
 1.21A 4ax8A-3c8zA:
undetectable		 4ax8A-3c8zA:
22.39
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3dls PAS
DOMAIN-CONTAINING
SERINE/THREONINE-PRO
TEIN KINASE

(Homo sapiens) 		PF00069
(Pkinase) 		4 GLN A1253
ARG A1110
ASP A1101
GLU A1264
 None
 1.42A 4ax8A-3dlsA:
3.4		 4ax8A-3dlsA:
20.58
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3e4b ALGK

(Pseudomonas
fluorescens) 		no annotation 4 GLN A 269
ASP A 275
GLU A 286
LEU A 254
 None
 1.14A 4ax8A-3e4bA:
undetectable		 4ax8A-3e4bA:
22.17
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3f8t PREDICTED ATPASE
INVOLVED IN
REPLICATION CONTROL,
CDC46/MCM FAMILY

(Methanopyrus
kandleri) 		PF00493
(MCM) 		4 ARG A 197
ASP A 475
GLU A 238
LEU A 467
 None
 1.22A 4ax8A-3f8tA:
undetectable		 4ax8A-3f8tA:
25.29
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3g4g CAMP-SPECIFIC
3',5'-CYCLIC
PHOSPHODIESTERASE 4D

(Homo sapiens) 		PF00233
(PDEase_I) 		4 TYR A 389
ASP A 369
GLU A 409
LEU A 400
 None
 1.21A 4ax8A-3g4gA:
undetectable		 4ax8A-3g4gA:
20.51
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3h2u RAVER-1

(Homo sapiens) 		PF00076
(RRM_1) 		4 ARG B 221
ASP B 209
GLU B 179
LEU B 217
 None
 1.41A 4ax8A-3h2uB:
undetectable		 4ax8A-3h2uB:
21.34
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3hea ARYLESTERASE

(Pseudomonas
fluorescens) 		PF00561
(Abhydrolase_1) 		4 TYR A 163
GLN A 176
GLU A 146
LEU A 180
 None
 1.21A 4ax8A-3heaA:
2.9		 4ax8A-3heaA:
18.71
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3hje 704AA LONG
HYPOTHETICAL
GLYCOSYLTRANSFERASE

(Sulfurisphaera
tokodaii) 		PF00128
(Alpha-amylase)
PF09196
(DUF1953) 		4 ARG A 588
ASP A 441
GLU A 514
LEU A 590
 None
GOL  A 802 ( 3.7A)
None
None
 1.27A 4ax8A-3hjeA:
undetectable		 4ax8A-3hjeA:
20.51
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3iup PUTATIVE
NADPH:QUINONE
OXIDOREDUCTASE

(Cupriavidus
pinatubonensis) 		no annotation 4 ARG A  68
ASP A  25
GLU A 103
LEU A   5
 None
EDO  A 381 (-3.3A)
None
None
 1.27A 4ax8A-3iupA:
5.5		 4ax8A-3iupA:
21.89
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3k9y 1,25-DIHYDROXYVITAMI
N D(3)
24-HYDROXYLASE,
MITOCHONDRIAL

(Rattus
norvegicus) 		PF00067
(p450) 		4 TYR A 220
ASP A 300
GLU A 171
LEU A 217
 None
 1.42A 4ax8A-3k9yA:
undetectable		 4ax8A-3k9yA:
22.24
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3kwl UNCHARACTERIZED
PROTEIN

(Helicobacter
pylori) 		no annotation 4 TYR A 276
ARG A 378
ASP A 273
LEU A 313
 None
 1.41A 4ax8A-3kwlA:
undetectable		 4ax8A-3kwlA:
23.24
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3lsc TRIAZINE HYDROLASE

(Paenarthrobacter
aurescens) 		PF01979
(Amidohydro_1) 		4 ARG A 419
ASP A 440
GLU A 109
LEU A 120
 None
 1.39A 4ax8A-3lscA:
undetectable		 4ax8A-3lscA:
22.49
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3mfq HIGH-AFFINITY ZINC
UPTAKE SYSTEM
PROTEIN ZNUA

(Streptococcus
suis) 		PF01297
(ZnuA) 		4 GLN A  49
ASP A 295
GLU A 182
LEU A 172
 None
 1.25A 4ax8A-3mfqA:
undetectable		 4ax8A-3mfqA:
21.14
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3oqv ALBC

(Streptomyces
noursei) 		PF16715
(CDPS) 		4 ARG A 117
ASP A 188
GLU A 133
LEU A 122
 None
 1.26A 4ax8A-3oqvA:
undetectable		 4ax8A-3oqvA:
19.18
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3pig BETA-FRUCTOFURANOSID
ASE

(Bifidobacterium
longum) 		PF00251
(Glyco_hydro_32N)
PF08244
(Glyco_hydro_32C) 		5 TYR A  40
ARG A  96
ASP A 465
GLU A 364
LEU A 517
 None
 1.21A 4ax8A-3pigA:
undetectable		 4ax8A-3pigA:
21.41
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3q41 GLUTAMATE [NMDA]
RECEPTOR SUBUNIT
ZETA-1

(Rattus
norvegicus) 		PF01094
(ANF_receptor) 		4 TYR A 351
GLN A 147
ARG A 124
GLU A 342
 None
 1.35A 4ax8A-3q41A:
3.6		 4ax8A-3q41A:
19.41
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3sl5 CAMP-SPECIFIC
3',5'-CYCLIC
PHOSPHODIESTERASE 4D

(Homo sapiens) 		PF00233
(PDEase_I) 		4 TYR A 223
ASP A 203
GLU A 243
LEU A 234
 TYR  A 223 ( 1.3A)
ASP  A 203 ( 0.6A)
GLU  A 243 ( 0.5A)
LEU  A 234 ( 0.6A)
 1.16A 4ax8A-3sl5A:
undetectable		 4ax8A-3sl5A:
21.36
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3u44 ATP-DEPENDENT
HELICASE/NUCLEASE
SUBUNIT A

(Bacillus
subtilis) 		PF00580
(UvrD-helicase)
PF12705
(PDDEXK_1)
PF13361
(UvrD_C) 		4 TYR A 187
GLN A 183
GLU A 863
LEU A 823
 None
 1.41A 4ax8A-3u44A:
undetectable		 4ax8A-3u44A:
19.72
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ayg GLUCANSUCRASE

(Lactobacillus
reuteri) 		PF01473
(CW_binding_1)
PF02324
(Glyco_hydro_70) 		4 TYR A1511
GLN A1509
GLU A 931
LEU A 940
 None
GOL  A2773 (-3.0A)
None
None
 1.27A 4ax8A-4aygA:
2.3		 4ax8A-4aygA:
20.81
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4azv WBDD

(Escherichia
coli) 		PF00069
(Pkinase)
PF13847
(Methyltransf_31) 		6 TYR A  16
GLN A  17
ARG A  36
ASP A  82
GLU A 111
LEU A 128
 SAM  A1474 (-3.5A)
SAM  A1474 (-3.5A)
SAM  A1474 ( 3.1A)
SAM  A1474 (-1.7A)
SAM  A1474 (-2.5A)
SAM  A1474 (-4.3A)
 0.09A 4ax8A-4azvA:
53.3		 4ax8A-4azvA:
99.82
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4azw WBDD

(Escherichia
coli) 		PF00069
(Pkinase)
PF13847
(Methyltransf_31) 		6 TYR A  16
GLN A  17
ARG A  36
ASP A  82
GLU A 111
LEU A 128
 SAM  A1451 (-3.6A)
SAM  A1451 (-3.9A)
SAM  A1451 (-3.2A)
SAM  A1451 (-2.7A)
SAM  A1451 (-3.1A)
SAM  A1451 (-4.1A)
 0.42A 4ax8A-4azwA:
51.5		 4ax8A-4azwA:
99.36
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4b67 L-ORNITHINE N5
MONOOXYGENASE

(Aspergillus
fumigatus) 		PF13434
(K_oxygenase) 		4 GLN A 102
ASP A 288
GLU A 294
LEU A 467
 NAP  A1493 (-4.0A)
None
None
FAD  A1492 (-3.8A)
 1.32A 4ax8A-4b67A:
2.4		 4ax8A-4b67A:
21.69
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4c25 L-FUCULOSE PHOSPHATE
ALDOLASE

(Streptococcus
pneumoniae) 		PF00596
(Aldolase_II) 		4 GLN A  36
ASP A  89
GLU A   7
LEU A  37
 None
 1.14A 4ax8A-4c25A:
undetectable		 4ax8A-4c25A:
16.23
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4fas HYDROXYLAMINE
OXIDOREDUCTASE

(Nitrosomonas
europaea) 		PF13447
(Multi-haem_cyto) 		4 TYR A  33
GLN A 236
ARG A 183
ASP A  59
 None
None
HEC  A 604 ( 4.3A)
None
 1.34A 4ax8A-4fasA:
undetectable		 4ax8A-4fasA:
19.47
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4g7w PUTATIVE
UNCHARACTERIZED
PROTEIN

(Vibrio cholerae) 		PF16710
(CTXphi_pIII-N1) 		4 GLN A  66
ASP A  35
GLU A  83
LEU A  28
 None
 1.01A 4ax8A-4g7wA:
undetectable		 4ax8A-4g7wA:
16.31
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4h1g MALTOSE BINDING
PROTEIN-CAKAR3 MOTOR
DOMAIN FUSION
PROTEIN

(Escherichia
coli;
Candida
albicans) 		PF00225
(Kinesin)
PF13416
(SBP_bac_8) 		4 ARG A 349
ASP A 432
GLU A 473
LEU A 426
 None
 1.40A 4ax8A-4h1gA:
undetectable		 4ax8A-4h1gA:
21.47
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4h3s GLUTAMINE-TRNA
LIGASE

(Saccharomyces
cerevisiae) 		PF00749
(tRNA-synt_1c)
PF03950
(tRNA-synt_1c_C)
PF04557
(tRNA_synt_1c_R2) 		4 TYR A 469
ASP A 474
GLU A 239
LEU A 446
 GOL  A 906 ( 4.9A)
None
None
None
 1.11A 4ax8A-4h3sA:
undetectable		 4ax8A-4h3sA:
20.51
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4hl0 GALECTIN

(Toxascaris
leonina) 		PF00337
(Gal-bind_lectin) 		4 TYR A 138
ASP A  94
GLU A 112
LEU A  25
 None
 1.40A 4ax8A-4hl0A:
undetectable		 4ax8A-4hl0A:
20.32
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4hvt POST-PROLINE
CLEAVING ENZYME

(Rickettsia
typhi) 		PF00326
(Peptidase_S9)
PF02897
(Peptidase_S9_N) 		4 GLN A  94
ASP A 679
GLU A  47
LEU A 688
 None
 1.00A 4ax8A-4hvtA:
undetectable		 4ax8A-4hvtA:
22.97
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4km3 METHIONINE
AMINOPEPTIDASE

(Streptococcus
pneumoniae) 		PF00557
(Peptidase_M24) 		4 TYR A  87
ASP A  77
GLU A 149
LEU A  95
 None
 1.27A 4ax8A-4km3A:
undetectable		 4ax8A-4km3A:
18.09
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4leu PENTATRICOPEPTIDE
REPEAT-CONTAINING
PROTEIN AT3G46870

(Arabidopsis
thaliana) 		PF13041
(PPR_2) 		4 ARG A 230
ASP A 248
GLU A 212
LEU A 220
 None
 1.40A 4ax8A-4leuA:
undetectable		 4ax8A-4leuA:
18.42
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4n0y IGH526 HEAVY CHAIN

(Homo sapiens) 		PF07654
(C1-set)
PF07686
(V-set) 		4 TYR H  27
GLN H   3
ASP H 101
LEU H   4
 None
 1.38A 4ax8A-4n0yH:
undetectable		 4ax8A-4n0yH:
17.54
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4nek ENOYL-COA
HYDRATASE/CARNITHINE
RACEMASE

(Magnetospirillum
magneticum) 		PF00378
(ECH_1) 		4 ARG A 218
ASP A 114
GLU A  43
LEU A 207
 None
 1.29A 4ax8A-4nekA:
undetectable		 4ax8A-4nekA:
18.38
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4pj3 INTRON-BINDING
PROTEIN AQUARIUS

(Homo sapiens) 		PF13086
(AAA_11)
PF13087
(AAA_12)
PF16399
(Aquarius_N) 		4 TYR A1112
ARG A 252
GLU A 158
LEU A 148
 None
 1.19A 4ax8A-4pj3A:
2.1		 4ax8A-4pj3A:
16.59
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4qhr ALANINE RACEMASE

(Acinetobacter
baumannii) 		PF00842
(Ala_racemase_C)
PF01168
(Ala_racemase_N) 		4 TYR A  15
ASP A   9
GLU A 321
LEU A 230
 None
 1.06A 4ax8A-4qhrA:
undetectable		 4ax8A-4qhrA:
22.05
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4r3u 2-HYDROXYISOBUTYRYL-
COA MUTASE LARGE
SUBUNIT

(Aquincola
tertiaricarbonis) 		PF01642
(MM_CoA_mutase) 		4 GLN A 526
ARG A 220
GLU A 184
LEU A 528
 None
 1.00A 4ax8A-4r3uA:
undetectable		 4ax8A-4r3uA:
22.62
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4rf7 ARGININE KINASE

(Anthopleura
japonica) 		PF00217
(ATP-gua_Ptrans)
PF02807
(ATP-gua_PtransN) 		4 ARG A 501
ASP A 408
GLU A 429
LEU A 496
 None
 1.26A 4ax8A-4rf7A:
undetectable		 4ax8A-4rf7A:
20.76
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4uxv SEPTATION RING
FORMATION REGULATOR
EZRA

(Bacillus
subtilis) 		PF06160
(EzrA) 		4 GLN A 406
ARG A 340
GLU A 417
LEU A 408
 None
 1.32A 4ax8A-4uxvA:
undetectable		 4ax8A-4uxvA:
23.70
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4wjl INACTIVE DIPEPTIDYL
PEPTIDASE 10

(Homo sapiens) 		PF00326
(Peptidase_S9)
PF00930
(DPPIV_N) 		4 GLN A 191
ASP A 247
GLU A 350
LEU A 251
 None
 1.15A 4ax8A-4wjlA:
undetectable		 4ax8A-4wjlA:
22.18
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4wzi CAMP-SPECIFIC
3',5'-CYCLIC
PHOSPHODIESTERASE 4B

(Homo sapiens) 		PF00233
(PDEase_I) 		4 TYR A 469
ASP A 449
GLU A 489
LEU A 480
 None
 1.23A 4ax8A-4wziA:
undetectable		 4ax8A-4wziA:
21.67
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4xgc ORIGIN RECOGNITION
COMPLEX SUBUNIT 5

(Drosophila
melanogaster) 		PF13191
(AAA_16)
PF14630
(ORC5_C) 		4 GLN E 182
ARG E  15
GLU E 164
LEU E 180
 None
 1.07A 4ax8A-4xgcE:
undetectable		 4ax8A-4xgcE:
23.20
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4yhg GH5

(Bacteroidetes
bacterium AC2a) 		PF00150
(Cellulase) 		4 GLN A 190
ASP A 129
GLU A 146
LEU A 194
 None
 1.24A 4ax8A-4yhgA:
undetectable		 4ax8A-4yhgA:
22.09
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4zwj CHIMERA PROTEIN OF
HUMAN RHODOPSIN,
MOUSE S-ARRESTIN,
AND T4 ENDOLYSIN

(Homo sapiens;
Mus musculus;
Escherichia
virus T4) 		PF00001
(7tm_1)
PF00339
(Arrestin_N)
PF00959
(Phage_lysozyme)
PF02752
(Arrestin_C)
PF10413
(Rhodopsin_N) 		4 ARG A 135
ASP A  83
GLU A 122
LEU A 131
 None
 1.36A 4ax8A-4zwjA:
undetectable		 4ax8A-4zwjA:
20.70
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5a29 EXOPOLYGALACTURONATE
LYASE

(Vibrio
vulnificus) 		PF06917
(Pectate_lyase_2) 		4 TYR A 157
ASP A 514
GLU A 517
LEU A  90
 EDO  A1574 ( 4.9A)
EDO  A1572 ( 4.7A)
None
None
 1.01A 4ax8A-5a29A:
undetectable		 4ax8A-5a29A:
22.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5cwa ANTHRANILATE
SYNTHASE COMPONENT 1

(Mycobacterium
tuberculosis) 		PF00425
(Chorismate_bind)
PF04715
(Anth_synt_I_N) 		4 ARG A 464
ASP A 156
GLU A 146
LEU A 152
 None
None
None
GOL  A 605 (-4.7A)
 1.41A 4ax8A-5cwaA:
2.5		 4ax8A-5cwaA:
21.43
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5fu7 CCR4-NOT
TRANSCRIPTION
COMPLEX SUBUNIT 1
CCR4-NOT
TRANSCRIPTION
COMPLEX SUBUNIT 2

(Homo sapiens;
Homo sapiens) 		PF04054
(Not1)
PF04153
(NOT2_3_5) 		4 ARG A2197
ASP B 353
GLU A2298
LEU A2258
 None
 1.24A 4ax8A-5fu7A:
undetectable		 4ax8A-5fu7A:
23.52
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5gai PORTAL PROTEIN

(Salmonella
virus P22) 		PF16510
(P22_portal) 		4 TYR A 447
ARG A 458
ASP A  77
LEU A  94
 None
 1.17A 4ax8A-5gaiA:
undetectable		 4ax8A-5gaiA:
22.07
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5h1a ICLR TRANSCRIPTION
FACTOR HOMOLOG

(Microbacterium
sp.) 		PF01614
(IclR)
PF09339
(HTH_IclR) 		4 GLN A  86
ASP A 244
GLU A 236
LEU A  89
 None
 1.20A 4ax8A-5h1aA:
undetectable		 4ax8A-5h1aA:
19.82
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5hb3 NUCLEOPORIN NIC96

(Chaetomium
thermophilum) 		PF04097
(Nic96) 		4 GLN A 652
ARG A 533
ASP A 542
LEU A 539
 None
 1.35A 4ax8A-5hb3A:
undetectable		 4ax8A-5hb3A:
23.70
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5hb4 NUP192,NUCLEOPORIN
NUP192

(Chaetomium
thermophilum) 		PF11894
(Nup192) 		4 ARG B 875
ASP B 390
GLU B 717
LEU B 787
 None
 1.23A 4ax8A-5hb4B:
undetectable		 4ax8A-5hb4B:
17.18
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5hr4 MMEI

(Methylophilus
methylotrophus) 		no annotation 4 ARG C 168
ASP C 201
GLU C 212
LEU C 282
 None
CA  C1001 (-2.1A)
None
None
 1.37A 4ax8A-5hr4C:
9.4		 4ax8A-5hr4C:
21.30
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5hwq HYDROXYMETHYLGLUTARY
L-COA SYNTHASE

(Myxococcus
xanthus) 		PF01154
(HMG_CoA_synt_N)
PF08540
(HMG_CoA_synt_C) 		4 GLN A 324
ARG A 306
ASP A 365
LEU A 370
 SO4  A 506 (-3.6A)
None
SO4  A 506 ( 4.9A)
None
 1.16A 4ax8A-5hwqA:
2.0		 4ax8A-5hwqA:
22.77
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ik2 ATP SYNTHASE SUBUNIT
ALPHA

(Caldalkalibacillus
thermarum) 		PF00006
(ATP-synt_ab)
PF00306
(ATP-synt_ab_C)
PF02874
(ATP-synt_ab_N) 		4 ARG A 465
ASP A 423
GLU A 418
LEU A 461
 None
 1.36A 4ax8A-5ik2A:
undetectable		 4ax8A-5ik2A:
23.73
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ip9 DNA-DIRECTED RNA
POLYMERASES I, II,
AND III SUBUNIT
RPABC3

(Saccharomyces
cerevisiae) 		PF03870
(RNA_pol_Rpb8) 		4 TYR H 115
ASP H  41
GLU H  14
LEU H 125
 None
 1.20A 4ax8A-5ip9H:
2.1		 4ax8A-5ip9H:
13.81
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5iv9 LPS-ASSEMBLY PROTEIN
LPTD
LPS-ASSEMBLY
LIPOPROTEIN LPTE

(Klebsiella
pneumoniae;
Klebsiella
pneumoniae) 		PF03968
(OstA)
PF04453
(OstA_C)
PF04390
(LptE) 		4 GLN A 369
ARG A 405
ASP B 141
LEU A 522
 None
 1.08A 4ax8A-5iv9A:
undetectable		 4ax8A-5iv9A:
21.03
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5k5m RNA DEPENDENT RNA
POLYMERASE

(Dengue virus) 		PF00972
(Flavi_NS5) 		4 GLN A 760
ASP A 808
GLU A 831
LEU A 764
 None
 1.27A 4ax8A-5k5mA:
undetectable		 4ax8A-5k5mA:
21.90
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ko9 EMBRYONIC STEM
CELL-SPECIFIC
5-HYDROXYMETHYLCYTOS
INE-BINDING PROTEIN

(Homo sapiens) 		PF02586
(SRAP) 		4 GLN A  27
ASP A  22
GLU A  60
LEU A  29
 None
 1.11A 4ax8A-5ko9A:
undetectable		 4ax8A-5ko9A:
18.20
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5lcw MITOTIC CHECKPOINT
SERINE/THREONINE-PRO
TEIN KINASE BUB1
BETA,MITOTIC
CHECKPOINT
SERINE/THREONINE-PRO
TEIN KINASE BUB1
BETA

(Homo sapiens) 		PF08311
(Mad3_BUB1_I) 		4 GLN S  91
ARG S  36
GLU S 161
LEU S  32
 None
 1.37A 4ax8A-5lcwS:
undetectable		 4ax8A-5lcwS:
22.90
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5mdn DNA POLYMERASE

(Pyrobaculum
calidifontis) 		PF00136
(DNA_pol_B)
PF03104
(DNA_pol_B_exo1) 		4 ARG A 305
ASP A 671
GLU A 318
LEU A 310
 None
 1.27A 4ax8A-5mdnA:
undetectable		 4ax8A-5mdnA:
22.28
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5n9j MEDIATOR OF RNA
POLYMERASE II
TRANSCRIPTION
SUBUNIT 14
MEDIATOR OF RNA
POLYMERASE II
TRANSCRIPTION
SUBUNIT 17

(Schizosaccharomyces
pombe;
Schizosaccharomyces
pombe) 		PF08638
(Med14)
PF10156
(Med17) 		4 GLN W 302
ASP W 309
GLU A 288
LEU W 301
 None
 1.36A 4ax8A-5n9jW:
undetectable		 4ax8A-5n9jW:
20.87
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5nju GENOME POLYPROTEIN

(Zika virus) 		no annotation 4 GLN A 238
ASP A 245
GLU A  23
LEU A 240
 None
 1.15A 4ax8A-5njuA:
8.6		 4ax8A-5njuA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5nug CYTOPLASMIC DYNEIN 1
HEAVY CHAIN 1

(Homo sapiens) 		PF03028
(Dynein_heavy)
PF07728
(AAA_5)
PF08393
(DHC_N2)
PF12774
(AAA_6)
PF12775
(AAA_7)
PF12777
(MT)
PF12780
(AAA_8)
PF12781
(AAA_9) 		4 ARG A3007
ASP A2636
GLU A3048
LEU A3020
 None
 1.32A 4ax8A-5nugA:
undetectable		 4ax8A-5nugA:
8.27
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5oa3 EUKARYOTIC
TRANSLATION
INITIATION FACTOR 2D

(Homo sapiens) 		no annotation 4 GLN 0 545
ARG 0 498
ASP 0 492
GLU 0 575
 None
 1.38A 4ax8A-5oa30:
2.1		 4ax8A-5oa30:
21.88
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ohj CAMP-SPECIFIC
3',5'-CYCLIC
PHOSPHODIESTERASE 4B

(Homo sapiens) 		no annotation 4 TYR A 469
ASP A 449
GLU A 489
LEU A 480
 None
 1.35A 4ax8A-5ohjA:
undetectable		 4ax8A-5ohjA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5sy4 CHAPERONE YAJL

(Escherichia
coli) 		PF01965
(DJ-1_PfpI) 		4 GLN A 138
ASP A 117
GLU A  90
LEU A 152
 None
 1.30A 4ax8A-5sy4A:
3.8		 4ax8A-5sy4A:
17.49
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5u89 AMINO ACID
ADENYLATION DOMAIN
PROTEIN

(Geobacillus sp.
Y4.1MC1) 		PF00501
(AMP-binding)
PF00550
(PP-binding)
PF00668
(Condensation)
PF13193
(AMP-binding_C) 		4 GLN A1227
ARG A1061
GLU A1105
LEU A1056
 None
 1.13A 4ax8A-5u89A:
3.6		 4ax8A-5u89A:
20.13
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5voc ENVELOPE
GLYCOPROTEIN H

(Human
betaherpesvirus
5) 		PF02489
(Herpes_glycop_H)
PF17488
(Herpes_glycoH_C) 		4 ARG A 421
ASP A 517
GLU A 499
LEU A 469
 None
 1.07A 4ax8A-5vocA:
undetectable		 4ax8A-5vocA:
21.39
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5wh6 CAMP-SPECIFIC
3',5'-CYCLIC
PHOSPHODIESTERASE 4D

(Homo sapiens) 		no annotation 4 TYR A 223
ASP A 203
GLU A 243
LEU A 234
 None
 1.22A 4ax8A-5wh6A:
undetectable		 4ax8A-5wh6A:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5z06 BDI_3064 PROTEIN

(Parabacteroides
distasonis) 		no annotation 4 TYR A 315
GLN A 685
GLU A  29
LEU A 679
 None
 1.30A 4ax8A-5z06A:
undetectable		 4ax8A-5z06A:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6bfi VIN1

(Oscarella
pearsei) 		no annotation 4 GLN A 358
ARG A 365
ASP A 280
GLU A 680
 None
 1.23A 4ax8A-6bfiA:
undetectable		 4ax8A-6bfiA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6bzh PROBABLE
ATP-DEPENDENT RNA
HELICASE DDX58

(Mus musculus) 		no annotation 4 TYR A  15
ARG A 104
ASP A  93
LEU A 100
 None
 1.21A 4ax8A-6bzhA:
undetectable		 4ax8A-6bzhA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6f5d ATP SYNTHASE GAMMA
SUBUNIT
ATP SYNTHASE DELTA
SUBUNIT
ATP SYNTHASE EPSILON
SUBUNIT

(Trypanosoma
brucei;
Trypanosoma
brucei;
Trypanosoma
brucei) 		no annotation
no annotation
no annotation 		4 TYR I  14
ASP G 215
GLU G 209
LEU H  75
 None
 1.29A 4ax8A-6f5dI:
undetectable		 4ax8A-6f5dI:
undetectable