SIMILAR PATTERNS OF AMINO ACIDS FOR 4AX8_A_SAMA1474_0

List of similar pattern of amino acids derived from ASSAM search

Hit pattern: 3D amino acid arrangements similar to known drug binding site

Query pattern: Residues from known binding site for annotated drug that match the hit pattern


(Click link on the last column to view superposed patterns of amino acids in NGL viewer)
(Note that only 3-12 residue patterns can be used for ASSAM searches)
Filter list by:
Hit Macromolecule/
Organism
Pfam Res. Interface HETATM RMSD Dali Z-score Seq. Identity (%) View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1cen CELLULASE CELC

(Ruminiclostridium
thermocellum)
PF00150
(Cellulase)
5 ASN A  82
ILE A  37
VAL A  45
HIS A  44
ILE A   8
None
0.98A 4ax8A-1cenA:
2.5
4ax8A-1cenA:
20.57
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1dy6 CARBAPENEM-HYDROLYSI
NG BETA-LACTAMASE
SME-1


(Serratia
marcescens)
PF13354
(Beta-lactamase2)
5 ARG A 256
ILE A 250
SER A 262
VAL A 261
ILE A 287
None
0.97A 4ax8A-1dy6A:
undetectable
4ax8A-1dy6A:
18.95
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ebd DIHYDROLIPOAMIDE
DEHYDROGENASE


(Geobacillus
stearothermophilus)
PF02852
(Pyr_redox_dim)
PF07992
(Pyr_redox_2)
5 GLY A 192
ALA A 194
ASN A 197
ILE A 204
ILE A 211
None
0.85A 4ax8A-1ebdA:
4.6
4ax8A-1ebdA:
22.49
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1fep FERRIC ENTEROBACTIN
RECEPTOR


(Escherichia
coli)
PF00593
(TonB_dep_Rec)
PF07715
(Plug)
5 ASN A 230
ILE A 119
SER A  46
VAL A  45
ILE A  36
None
0.97A 4ax8A-1fepA:
undetectable
4ax8A-1fepA:
21.47
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1hq0 CYTOTOXIC
NECROTIZING FACTOR 1


(Escherichia
coli)
PF05785
(CNF1)
5 GLY A 842
ILE A 843
SER A 834
VAL A 833
ILE A 831
None
None
PO4  A 302 ( 4.5A)
None
None
0.94A 4ax8A-1hq0A:
undetectable
4ax8A-1hq0A:
19.28
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1hq0 CYTOTOXIC
NECROTIZING FACTOR 1


(Escherichia
coli)
PF05785
(CNF1)
5 GLY A 842
ILE A 843
SER A 834
VAL A 833
ILE A 858
None
None
PO4  A 302 ( 4.5A)
None
None
0.94A 4ax8A-1hq0A:
undetectable
4ax8A-1hq0A:
19.28
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1kkr 3-METHYLASPARTATE
AMMONIA-LYASE


(Citrobacter
amalonaticus)
PF05034
(MAAL_N)
PF07476
(MAAL_C)
6 GLY A 274
ILE A 304
GLN A 329
ILE A 272
HIS A 194
ILE A 237
None
None
2AS  A 801 (-3.5A)
None
2AS  A 801 (-3.8A)
None
1.22A 4ax8A-1kkrA:
undetectable
4ax8A-1kkrA:
23.16
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1kkr 3-METHYLASPARTATE
AMMONIA-LYASE


(Citrobacter
amalonaticus)
PF05034
(MAAL_N)
PF07476
(MAAL_C)
6 GLY A 274
ILE A 304
GLN A 329
ILE A 272
VAL A 239
ILE A 237
None
None
2AS  A 801 (-3.5A)
None
None
None
1.19A 4ax8A-1kkrA:
undetectable
4ax8A-1kkrA:
23.16
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1lml LEISHMANOLYSIN

(Leishmania
major)
PF01457
(Peptidase_M8)
5 ALA A 486
ILE A 490
SER A 523
VAL A 524
ILE A 556
None
0.97A 4ax8A-1lmlA:
undetectable
4ax8A-1lmlA:
21.11
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1q5a EP-CADHERIN

(Mus musculus)
PF00028
(Cadherin)
5 GLY A 115
ILE A 208
ILE A 209
VAL A 127
ILE A 172
None
NAG  A 801 ( 4.7A)
None
None
None
0.24A 4ax8A-1q5aA:
undetectable
4ax8A-1q5aA:
20.38
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1rf5 5-ENOLPYRUVYLSHIKIMA
TE-3-PHOSPHATE
SYNTHASE


(Streptococcus
pneumoniae)
PF00275
(EPSP_synthase)
6 GLY A  30
ALA A  33
ILE A  28
ILE A  27
VAL A  71
ILE A  69
None
1.04A 4ax8A-1rf5A:
undetectable
4ax8A-1rf5A:
21.60
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1wa5 IMPORTIN ALPHA
SUBUNIT


(Saccharomyces
cerevisiae)
PF00514
(Arm)
PF01749
(IBB)
PF16186
(Arm_3)
5 ILE B 477
ILE B 455
SER B 426
VAL B 425
ILE B 421
None
1.00A 4ax8A-1wa5B:
undetectable
4ax8A-1wa5B:
22.58
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1wuf HYPOTHETICAL PROTEIN
LIN2664


(Listeria
innocua)
PF02746
(MR_MLE_N)
PF13378
(MR_MLE_C)
5 GLY A1046
ILE A1034
ILE A1033
VAL A1297
ILE A1328
None
0.95A 4ax8A-1wufA:
undetectable
4ax8A-1wufA:
21.96
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1z6x ADP-RIBOSYLATION
FACTOR 4


(Homo sapiens)
PF00025
(Arf)
5 GLY A  29
ALA A  27
ILE A  33
VAL A  91
ILE A  89
GDP  A 201 (-3.0A)
GDP  A 201 (-4.1A)
None
None
None
0.87A 4ax8A-1z6xA:
2.5
4ax8A-1z6xA:
14.39
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2e5f HYPOTHETICAL PROTEIN
PH0510


(Pyrococcus
horikoshii)
PF01380
(SIS)
5 GLY A  13
ILE A  15
ILE A  14
SER A 138
ILE A 292
None
0.81A 4ax8A-2e5fA:
3.6
4ax8A-2e5fA:
21.54
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2ji9 OXALYL-COA
DECARBOXYLASE


(Oxalobacter
formigenes)
PF00205
(TPP_enzyme_M)
PF02775
(TPP_enzyme_C)
PF02776
(TPP_enzyme_N)
6 ALA A 235
ILE A 218
ILE A 279
SER A 331
VAL A 330
ILE A 326
None
None
None
None
None
ADP  A1556 (-4.0A)
1.26A 4ax8A-2ji9A:
2.6
4ax8A-2ji9A:
22.31
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2m71 TRANSLATION
INITIATION FACTOR
IF-3


(Campylobacter
jejuni)
PF00707
(IF3_C)
5 GLY A  56
ALA A  55
PHE A  79
SER A  14
VAL A  43
None
0.98A 4ax8A-2m71A:
3.9
4ax8A-2m71A:
10.52
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2nzu CATABOLITE CONTROL
PROTEIN


(Bacillus
megaterium)
PF13377
(Peripla_BP_3)
5 GLY G 226
ILE G 227
SER G 184
VAL G 183
ILE G 243
None
0.89A 4ax8A-2nzuG:
3.3
4ax8A-2nzuG:
19.06
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2p8j S-ADENOSYLMETHIONINE
-DEPENDENT
METHYLTRANSFERASE


(Clostridium
acetobutylicum)
PF08241
(Methyltransf_11)
5 GLY A  30
ILE A  51
GLN A  57
ILE A  79
HIS A 100
GOL  A 213 ( 3.7A)
None
None
GOL  A 213 ( 4.6A)
None
0.99A 4ax8A-2p8jA:
14.9
4ax8A-2p8jA:
16.05
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2po2 PROBABLE EXOSOME
COMPLEX EXONUCLEASE
2


(Pyrococcus
abyssi)
PF01138
(RNase_PH)
PF03725
(RNase_PH_C)
5 ILE B 158
ASN B 163
ILE B 155
VAL B  52
ILE B  36
None
0.92A 4ax8A-2po2B:
undetectable
4ax8A-2po2B:
20.67
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2v0j BIFUNCTIONAL PROTEIN
GLMU


(Haemophilus
influenzae)
PF00132
(Hexapep)
PF12804
(NTP_transf_3)
5 GLY A 321
ALA A 340
ILE A 319
VAL A 307
ILE A 309
None
0.99A 4ax8A-2v0jA:
undetectable
4ax8A-2v0jA:
22.50
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2v1o CYTOSOLIC ACYL
COENZYME A THIOESTER
HYDROLASE


(Mus musculus)
PF03061
(4HBT)
5 GLY A  42
ILE A  44
ILE A  45
VAL A  96
ILE A  86
None
0.92A 4ax8A-2v1oA:
undetectable
4ax8A-2v1oA:
14.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2vo1 CTP SYNTHASE 1

(Homo sapiens)
PF06418
(CTP_synth_N)
6 GLY A  15
ILE A  18
ILE A  19
SER A 181
VAL A 180
ILE A 178
SO4  A1273 (-3.1A)
None
None
None
None
None
0.85A 4ax8A-2vo1A:
undetectable
4ax8A-2vo1A:
19.21
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2vo1 CTP SYNTHASE 1

(Homo sapiens)
PF06418
(CTP_synth_N)
6 ILE A  18
ILE A  19
SER A 181
VAL A 180
HIS A 179
ILE A 178
None
1.25A 4ax8A-2vo1A:
undetectable
4ax8A-2vo1A:
19.21
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2wbn TERMINASE LARGE
SUBUNIT


(Bacillus phage
SPP1)
PF17288
(Terminase_3C)
5 GLY A 264
ALA A 404
ILE A 319
PHE A 409
ILE A 261
None
0.84A 4ax8A-2wbnA:
undetectable
4ax8A-2wbnA:
17.10
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2wfi PEPTIDYL-PROLYL
CIS-TRANS ISOMERASE
G


(Homo sapiens)
PF00160
(Pro_isomerase)
5 GLY A  22
GLN A  19
ILE A  14
VAL A 150
ILE A 154
None
0.99A 4ax8A-2wfiA:
undetectable
4ax8A-2wfiA:
16.73
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2xk0 POLYCOMB PROTEIN PCL

(Drosophila
melanogaster)
no annotation 6 ALA A  23
ILE A  43
GLN A  45
ILE A  52
VAL A  28
ILE A  30
None
1.43A 4ax8A-2xk0A:
undetectable
4ax8A-2xk0A:
8.89
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2y6p 3-DEOXY-MANNO-OCTULO
SONATE
CYTIDYLYLTRANSFERASE


(Aquifex
aeolicus)
PF02348
(CTP_transf_3)
5 GLY A 171
ILE A  89
ARG A   3
ILE A  90
ILE A 104
None
0.86A 4ax8A-2y6pA:
undetectable
4ax8A-2y6pA:
17.36
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2yk6 CMP-N-ACETYLNEURAMIN
ATE-BETA-GALACTOSAMI
DE-ALPHA-2,3-SIALYLT
RANSFERASE


(Neisseria
meningitidis)
PF07922
(Glyco_transf_52)
5 ALA A 325
ILE A 299
ILE A 303
VAL A 334
ILE A 307
None
CDP  A1374 (-4.1A)
None
None
None
0.99A 4ax8A-2yk6A:
2.1
4ax8A-2yk6A:
20.87
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2z8z LIPASE

(Pseudomonas sp.
MIS38)
PF00353
(HemolysinCabind)
5 GLY A 321
ALA A 317
ILE A 325
VAL A 342
ILE A 340
None
0.83A 4ax8A-2z8zA:
undetectable
4ax8A-2z8zA:
22.42
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3aq4 ADP-RIBOSYLATION
FACTOR 1


(Arabidopsis
thaliana)
PF00025
(Arf)
5 GLY A  29
ALA A  27
ILE A  33
VAL A  91
ILE A  89
GDP  A 183 (-3.3A)
GDP  A 183 (-4.3A)
None
None
None
0.87A 4ax8A-3aq4A:
undetectable
4ax8A-3aq4A:
15.04
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3bxz PREPROTEIN
TRANSLOCASE SUBUNIT
SECA


(Escherichia
coli)
PF07517
(SecA_DEAD)
6 ALA A 503
ILE A 557
ILE A 442
VAL A 500
HIS A 476
ILE A 474
None
1.43A 4ax8A-3bxzA:
3.3
4ax8A-3bxzA:
22.71
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3e11 PREDICTED
ZINCIN-LIKE
METALLOPROTEASE


(Acidothermus
cellulolyticus)
PF06262
(Zincin_1)
5 GLY A  46
ILE A  69
ILE A  68
HIS A  99
ILE A  97
None
0.90A 4ax8A-3e11A:
undetectable
4ax8A-3e11A:
13.20
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ebv CHINITASE A

(Streptomyces
coelicolor)
PF00704
(Glyco_hydro_18)
5 ALA A  29
ILE A  32
ILE A  33
VAL A  26
ILE A  23
None
0.96A 4ax8A-3ebvA:
undetectable
4ax8A-3ebvA:
18.65
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3h7t GROUP 3 ALLERGEN
SMIPP-S YVT004A06


(Sarcoptes
scabiei)
PF00089
(Trypsin)
5 GLY A  28
ALA A  15
ILE A  37
VAL A  18
ILE A  51
None
0.88A 4ax8A-3h7tA:
undetectable
4ax8A-3h7tA:
16.98
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3hxg EUKARYOTIC
TRANSLATION
INITIATION FACTOR 4E


(Schistosoma
mansoni)
PF01652
(IF4E)
5 GLY A 137
ILE A 135
SER A 150
VAL A 151
ILE A 165
None
0.99A 4ax8A-3hxgA:
undetectable
4ax8A-3hxgA:
15.82
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ihl CTP SYNTHASE 2

(Homo sapiens)
PF06418
(CTP_synth_N)
6 GLY A  15
ILE A  18
ILE A  19
SER A 181
VAL A 180
ILE A 178
ADP  A 300 (-3.4A)
ADP  A 300 (-4.3A)
None
None
None
None
0.80A 4ax8A-3ihlA:
undetectable
4ax8A-3ihlA:
18.31
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3il3 3-OXOACYL-[ACYL-CARR
IER-PROTEIN]
SYNTHASE 3


(Haemophilus
influenzae)
PF08541
(ACP_syn_III_C)
PF08545
(ACP_syn_III)
5 ALA A  58
ILE A 165
ASN A  61
ILE A  73
ILE A 100
None
0.93A 4ax8A-3il3A:
2.0
4ax8A-3il3A:
21.68
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3lrp ADP-RIBOSYLATION
FACTOR 1


(Plasmodium
falciparum)
PF00025
(Arf)
5 GLY A  29
ALA A  27
ILE A  33
VAL A  91
ILE A  89
GDP  A 182 (-3.1A)
GDP  A 182 (-4.3A)
None
None
None
0.92A 4ax8A-3lrpA:
3.3
4ax8A-3lrpA:
14.52
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3lvr ARF-GAP WITH SH3
DOMAIN, ANK REPEAT
AND PH
DOMAIN-CONTAINING
PROTEIN 3,
ADP-RIBOSYLATION
FACTOR 6


(Homo sapiens;
synthetic
construct)
PF00025
(Arf)
PF01412
(ArfGap)
PF12796
(Ank_2)
5 GLY E  25
ALA E  23
ILE E  29
VAL E  87
ILE E  85
GDP  E 737 (-3.2A)
GDP  E 737 ( 4.4A)
None
None
None
0.86A 4ax8A-3lvrE:
3.0
4ax8A-3lvrE:
23.13
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3m1r FORMIMIDOYLGLUTAMASE

(Bacillus
subtilis)
PF00491
(Arginase)
6 GLY A 124
ALA A  54
ILE A 285
ILE A 122
VAL A  42
ILE A  40
None
1.41A 4ax8A-3m1rA:
5.1
4ax8A-3m1rA:
21.39
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3mst PUTATIVE NITRATE
TRANSPORT PROTEIN


(Thermoplasma
volcanium)
PF12916
(DUF3834)
5 GLY A 159
ALA A 155
ILE A 160
VAL A  17
ILE A 174
None
EDO  A 233 (-3.8A)
None
None
None
0.90A 4ax8A-3mstA:
undetectable
4ax8A-3mstA:
19.48
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3nzq BIOSYNTHETIC
ARGININE
DECARBOXYLASE


(Escherichia
coli)
PF02784
(Orn_Arg_deC_N)
5 ALA A 346
ILE A 340
ILE A 339
VAL A 287
ILE A 283
None
0.97A 4ax8A-3nzqA:
2.4
4ax8A-3nzqA:
22.67
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3o47 ADP-RIBOSYLATION
FACTOR
GTPASE-ACTIVATING
PROTEIN 1,
ADP-RIBOSYLATION
FACTOR 1


(Homo sapiens)
PF00025
(Arf)
PF01412
(ArfGap)
5 GLY A 159
ALA A 157
ILE A 163
VAL A 221
ILE A 219
GDP  A 502 (-3.2A)
GDP  A 502 (-4.4A)
None
None
None
0.84A 4ax8A-3o47A:
undetectable
4ax8A-3o47A:
21.95
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3pbp NUCLEOPORIN
NUP116/NSP116


(Saccharomyces
cerevisiae)
PF04096
(Nucleoporin2)
5 GLY B1020
ASN B 967
ILE B1024
VAL B 995
ILE B1003
None
0.98A 4ax8A-3pbpB:
undetectable
4ax8A-3pbpB:
13.90
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3qi7 PUTATIVE
TRANSCRIPTIONAL
REGULATOR


(Clostridioides
difficile)
PF12683
(DUF3798)
5 ILE A 100
ILE A 103
SER A 118
VAL A 117
ILE A 115
None
0.87A 4ax8A-3qi7A:
2.5
4ax8A-3qi7A:
20.55
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3r38 UDP-N-ACETYLGLUCOSAM
INE
1-CARBOXYVINYLTRANSF
ERASE 1


(Listeria
monocytogenes)
PF00275
(EPSP_synthase)
5 GLY A 380
ALA A 383
ILE A 377
VAL A   6
ILE A   4
None
0.99A 4ax8A-3r38A:
undetectable
4ax8A-3r38A:
24.87
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3rrw THYLAKOID LUMENAL 29
KDA PROTEIN,
CHLOROPLASTIC


(Arabidopsis
thaliana)
PF00141
(peroxidase)
5 GLY A  57
ILE A  59
ILE A 102
SER A 152
ILE A 101
None
None
None
GOL  A 273 ( 4.5A)
None
0.99A 4ax8A-3rrwA:
undetectable
4ax8A-3rrwA:
18.92
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3s7z PUTATIVE ASPARTATE
RACEMASE


(Salmonella
enterica)
PF01177
(Asp_Glu_race)
5 ALA A 170
ILE A 178
VAL A 200
HIS A 203
ILE A 207
None
0.89A 4ax8A-3s7zA:
undetectable
4ax8A-3s7zA:
20.32
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3t6c PUTATIVE MAND FAMILY
DEHYDRATASE


(Pantoea
ananatis)
PF02746
(MR_MLE_N)
PF13378
(MR_MLE_C)
5 GLY A 103
ALA A 106
ILE A 101
VAL A 110
ILE A 305
None
0.92A 4ax8A-3t6cA:
undetectable
4ax8A-3t6cA:
22.54
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ulv FAB12 HEAVY CHAIN

(Homo sapiens)
PF07654
(C1-set)
PF07686
(V-set)
5 GLY D  37
ALA D 100
GLN D   6
ILE D  73
ILE D  71
None
0.91A 4ax8A-3ulvD:
undetectable
4ax8A-3ulvD:
17.74
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3v9f TWO-COMPONENT SYSTEM
SENSOR HISTIDINE
KINASE/RESPONSE
REGULATOR, HYBRID
(ONE-COMPONENT
SYSTEM)


(Bacteroides
thetaiotaomicron)
PF07494
(Reg_prop)
PF07495
(Y_Y_Y)
5 GLY A 296
ALA A 330
ILE A 297
ASN A 329
ILE A 277
None
0.91A 4ax8A-3v9fA:
undetectable
4ax8A-3v9fA:
21.77
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3w1z HEAT SHOCK PROTEIN
16


(Schizosaccharomyces
pombe)
PF00011
(HSP20)
5 ALA A 108
PHE A  17
ILE A 104
SER A  49
ILE A  39
None
0.90A 4ax8A-3w1zA:
undetectable
4ax8A-3w1zA:
13.19
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3w25 GLYCOSIDE HYDROLASE
FAMILY 10


(Thermoanaerobacterium
saccharolyticum)
PF00331
(Glyco_hydro_10)
5 ILE A 186
PHE A 185
ILE A 218
VAL A 245
ILE A 247
None
0.95A 4ax8A-3w25A:
undetectable
4ax8A-3w25A:
20.59
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ads PYRIDOXINE
BIOSYNTHETIC ENZYME
PDX1 HOMOLOGUE,
PUTATIVE


(Plasmodium
berghei)
PF01680
(SOR_SNZ)
6 GLY A 217
ALA A 155
ILE A 218
ILE A 160
HIS A 166
ILE A 164
PO4  A 302 (-3.8A)
PO4  A 302 ( 4.1A)
None
None
None
None
1.49A 4ax8A-4adsA:
undetectable
4ax8A-4adsA:
22.41
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4azv WBDD

(Escherichia
coli)
PF00069
(Pkinase)
PF13847
(Methyltransf_31)
11 GLY A  61
ALA A  63
ILE A  81
PHE A  83
GLN A  84
ASN A  87
ILE A 110
SER A 129
VAL A 130
HIS A 133
ILE A 134
SAM  A1474 (-3.2A)
SAM  A1474 (-3.0A)
SAM  A1474 ( 4.5A)
SAM  A1474 (-3.6A)
SAM  A1474 (-3.9A)
SAM  A1474 (-3.7A)
SAM  A1474 (-3.8A)
SAM  A1474 ( 4.5A)
SAM  A1474 ( 3.4A)
SAM  A1474 (-3.8A)
SAM  A1474 ( 4.8A)
0.15A 4ax8A-4azvA:
53.3
4ax8A-4azvA:
99.82
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4azv WBDD

(Escherichia
coli)
PF00069
(Pkinase)
PF13847
(Methyltransf_31)
6 GLY A  61
ILE A  81
ARG A 109
ILE A 110
VAL A 130
ILE A 134
SAM  A1474 (-3.2A)
SAM  A1474 ( 4.5A)
SAM  A1474 (-4.8A)
SAM  A1474 (-3.8A)
SAM  A1474 ( 3.4A)
SAM  A1474 ( 4.8A)
0.97A 4ax8A-4azvA:
53.3
4ax8A-4azvA:
99.82
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4azw WBDD

(Escherichia
coli)
PF00069
(Pkinase)
PF13847
(Methyltransf_31)
12 GLY A  61
ALA A  63
ILE A  81
PHE A  83
GLN A  84
ASN A  87
ARG A 109
ILE A 110
SER A 129
VAL A 130
HIS A 133
ILE A 134
SAM  A1451 (-3.6A)
SAM  A1451 (-3.7A)
None
SAM  A1451 (-3.5A)
SAM  A1451 (-4.2A)
SAM  A1451 (-4.0A)
SAM  A1451 (-3.9A)
SAM  A1451 (-4.0A)
SAM  A1451 (-4.5A)
SAM  A1451 (-4.6A)
None
None
0.28A 4ax8A-4azwA:
51.5
4ax8A-4azwA:
99.36
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4c2k 3-KETOACYL-COA
THIOLASE,
MITOCHONDRIAL


(Homo sapiens)
PF00108
(Thiolase_N)
PF02803
(Thiolase_C)
5 ILE A 262
GLN A 104
ASN A 101
ILE A 279
VAL A 391
None
0.94A 4ax8A-4c2kA:
undetectable
4ax8A-4c2kA:
22.20
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4de8 CPS2A

(Streptococcus
pneumoniae)
PF02916
(DNA_PPF)
PF03816
(LytR_cpsA_psr)
5 ILE A 385
GLN A 379
SER A 231
VAL A 230
ILE A 228
0K3  A 501 ( 4.2A)
None
None
None
None
1.00A 4ax8A-4de8A:
undetectable
4ax8A-4de8A:
22.13
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4dsq PEROXIREDOXIN TYPE-2

(Saccharomyces
cerevisiae)
PF08534
(Redoxin)
5 ILE A  51
ILE A  50
SER A 171
VAL A 172
HIS A 175
None
1.00A 4ax8A-4dsqA:
undetectable
4ax8A-4dsqA:
15.61
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4e7n SNAKE-VENOM
THROMBIN-LIKE ENZYME


(Gloydius halys)
PF00089
(Trypsin)
5 GLY A 142
ILE A 144
ILE A  16
SER A 195
ILE A 138
None
1.00A 4ax8A-4e7nA:
undetectable
4ax8A-4e7nA:
18.08
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4eht ACTIVATOR OF
2-HYDROXYISOCAPROYL-
COA DEHYDRATASE


(Clostridioides
difficile)
PF01869
(BcrAD_BadFG)
6 GLY A 128
ALA A 127
ILE A 100
SER A 199
VAL A 197
ILE A  98
None
SF4  A 301 ( 4.4A)
None
None
None
None
1.46A 4ax8A-4ehtA:
undetectable
4ax8A-4ehtA:
18.24
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4fcx DNA REPAIR PROTEIN
RAD32


(Schizosaccharomyces
pombe)
no annotation 5 GLN B 240
ILE B 186
SER B 170
VAL B 169
ILE B 167
None
0.94A 4ax8A-4fcxB:
undetectable
4ax8A-4fcxB:
22.28
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4fe4 XYLOSE OPERON
REGULATORY PROTEIN


(Escherichia
coli)
PF12833
(HTH_18)
PF13377
(Peripla_BP_3)
5 GLY A 186
ALA A 123
ILE A 216
PHE A 111
VAL A 119
None
0.95A 4ax8A-4fe4A:
3.5
4ax8A-4fe4A:
21.69
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4fme ADP-RIBOSYLATION
FACTOR 6


(Homo sapiens)
PF00025
(Arf)
5 GLY C  25
ALA C  23
ILE C  29
VAL C  87
ILE C  85
GTP  C 201 (-3.0A)
GTP  C 201 (-4.5A)
None
None
None
0.89A 4ax8A-4fmeC:
undetectable
4ax8A-4fmeC:
14.47
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4h6x THIAZOLINE
OXIDASE/SUBTILISIN-L
IKE PROTEASE


(Prochloron
didemni)
PF00082
(Peptidase_S8)
5 ALA A 785
ILE A 792
SER A 713
VAL A 712
ILE A 679
None
0.99A 4ax8A-4h6xA:
undetectable
4ax8A-4h6xA:
19.75
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ihc MANDELATE
RACEMASE/MUCONATE
LACTONIZING PROTEIN


(Dickeya
paradisiaca)
PF02746
(MR_MLE_N)
PF13378
(MR_MLE_C)
5 GLY A 103
ALA A 106
ILE A 101
VAL A 110
ILE A 305
None
0.94A 4ax8A-4ihcA:
2.3
4ax8A-4ihcA:
23.14
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ilr CRISPR-ASSOCIATED
ENDORIBONUCLEASE
CAS6 2


(Sulfolobus
solfataricus)
PF10040
(CRISPR_Cas6)
5 GLY A 271
ILE A  53
PHE A  54
ILE A  55
HIS A  57
None
0.99A 4ax8A-4ilrA:
undetectable
4ax8A-4ilrA:
17.71
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4lgi UNCHARACTERIZED
PROTEIN


(Escherichia
coli)
PF13678
(Peptidase_M85)
5 ILE A 182
ILE A 185
SER A 162
VAL A 161
ILE A 108
None
0.96A 4ax8A-4lgiA:
undetectable
4ax8A-4lgiA:
19.47
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4mio INOSITOL
2-DEHYDROGENASE/D-CH
IRO-INOSITOL
3-DEHYDROGENASE


(Lactobacillus
casei)
PF01408
(GFO_IDH_MocA)
5 GLY A  14
ALA A  12
ILE A  18
VAL A  73
ILE A   8
None
NAI  A 401 (-3.6A)
None
NAI  A 401 (-4.6A)
None
0.96A 4ax8A-4mioA:
5.2
4ax8A-4mioA:
19.90
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4mz0 CURL

(Moorea
producens)
PF00109
(ketoacyl-synt)
PF00698
(Acyl_transf_1)
PF02801
(Ketoacyl-synt_C)
PF16197
(KAsynt_C_assoc)
5 GLY A 393
ALA A 389
SER A 447
VAL A 446
ILE A 460
None
0.95A 4ax8A-4mz0A:
undetectable
4ax8A-4mz0A:
21.35
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4oja SUPEROXIDE DISMUTASE
[CU-ZN]


(Hydra vulgaris)
PF00080
(Sod_Cu)
6 GLY A  43
ALA A 139
GLN A 120
ASN A 121
ILE A  86
ILE A  33
None
1.24A 4ax8A-4ojaA:
undetectable
4ax8A-4ojaA:
14.41
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4pzv 2-AMINO-4-HYDROXY-6-
HYDROXYMETHYLDIHYDRO
PTERIDINE
PYROPHOSPHOKINASE/DI
HYDROPTEROATE
SYNTHASE


(Francisella
tularensis)
PF00809
(Pterin_bind)
PF01288
(HPPK)
5 ALA A 168
ASN A 169
ILE A  18
SER A  38
ILE A   7
None
0.94A 4ax8A-4pzvA:
undetectable
4ax8A-4pzvA:
21.02
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4rvh D-MYCAROSE
3-C-METHYLTRANSFERAS
E


(Streptomyces
argillaceus)
PF08421
(Methyltransf_13)
PF08484
(Methyltransf_14)
PF13489
(Methyltransf_23)
5 GLY A 114
ILE A 134
VAL A 179
HIS A 182
ILE A 183
SAH  A 502 (-3.5A)
None
SAH  A 502 (-4.2A)
3YN  A 503 (-3.9A)
SAH  A 502 (-4.2A)
0.70A 4ax8A-4rvhA:
12.6
4ax8A-4rvhA:
21.75
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4xni DI-OR TRIPEPTIDE:H+
SYMPORTER


(Streptococcus
thermophilus)
PF00854
(PTR2)
5 GLY A  91
ALA A  87
ASN A 128
ILE A  95
ILE A 118
None
0.98A 4ax8A-4xniA:
undetectable
4ax8A-4xniA:
22.46
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ylg ADP-RIBOSYLATION
FACTOR


(Entamoeba
histolytica)
PF00025
(Arf)
5 GLY A  25
ALA A  23
ILE A  29
VAL A  87
ILE A  85
GDP  A 201 (-3.3A)
GDP  A 201 (-4.2A)
None
None
None
0.86A 4ax8A-4ylgA:
undetectable
4ax8A-4ylgA:
15.28
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4z0z AURONE SYNTHASE

(Coreopsis
grandiflora)
PF00264
(Tyrosinase)
PF12142
(PPO1_DWL)
5 GLN A 203
ASN A 207
ILE A 160
HIS A 181
ILE A 182
None
0.94A 4ax8A-4z0zA:
undetectable
4ax8A-4z0zA:
18.29
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4zv3 CYTOSOLIC ACYL
COENZYME A THIOESTER
HYDROLASE


(Mus musculus)
PF03061
(4HBT)
5 GLY A  88
ILE A  90
ILE A  91
VAL A 142
ILE A 132
None
0.94A 4ax8A-4zv3A:
undetectable
4ax8A-4zv3A:
17.50
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5c1e PECTINESTERASE

(Aspergillus
niger)
PF01095
(Pectinesterase)
5 ILE A 228
ASN A 230
ILE A 258
VAL A 309
ILE A 305
None
0.99A 4ax8A-5c1eA:
undetectable
4ax8A-5c1eA:
19.82
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5cyx PROTEIN CDHR2

(Mus musculus)
PF00028
(Cadherin)
5 ALA A 234
ARG A 322
ILE A 321
SER A 239
VAL A 240
None
1.00A 4ax8A-5cyxA:
undetectable
4ax8A-5cyxA:
19.34
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5dds CRMG

(Actinoalloteichus
sp. WH1-2216-6)
PF00202
(Aminotran_3)
5 GLY A 322
ALA A 326
ILE A 321
ILE A  59
VAL A 403
None
1.00A 4ax8A-5ddsA:
undetectable
4ax8A-5ddsA:
22.56
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5e6k POLYKETIDE SYNTHASE
PKSL


(Bacillus
subtilis)
PF00109
(ketoacyl-synt)
PF02801
(Ketoacyl-synt_C)
PF16197
(KAsynt_C_assoc)
5 GLY A 353
ALA A 349
SER A 408
VAL A 407
ILE A 421
None
0.97A 4ax8A-5e6kA:
undetectable
4ax8A-5e6kA:
23.68
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5eny POLYKETIDE SYNTHASE
PKSL


(Bacillus
subtilis)
PF00109
(ketoacyl-synt)
PF02801
(Ketoacyl-synt_C)
PF16197
(KAsynt_C_assoc)
5 GLY A 353
ALA A 349
SER A 408
VAL A 407
ILE A 421
None
0.96A 4ax8A-5enyA:
2.3
4ax8A-5enyA:
22.21
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5eoe BETA-LACTAMASE

(Pseudomonas
aeruginosa)
PF13354
(Beta-lactamase2)
5 GLY A  51
ILE A  26
SER A 253
VAL A  39
ILE A  37
None
0.99A 4ax8A-5eoeA:
undetectable
4ax8A-5eoeA:
19.37
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5feu NOROXOMARITIDINE/NOR
CRAUGSODINE
REDUCTASE


(Narcissus
pseudonarcissus)
PF13561
(adh_short_C2)
5 ILE A 261
ILE A 203
VAL A 158
HIS A 159
ILE A 160
None
None
None
None
NAP  A 301 (-4.3A)
0.98A 4ax8A-5feuA:
7.5
4ax8A-5feuA:
21.35
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ff9 NOROXOMARITIDINE/NOR
CRAUGSODINE
REDUCTASE


(Narcissus
pseudonarcissus)
PF13561
(adh_short_C2)
5 ILE A 261
ILE A 203
VAL A 158
HIS A 159
ILE A 160
None
None
None
None
NAP  A 301 (-4.3A)
0.96A 4ax8A-5ff9A:
7.5
4ax8A-5ff9A:
19.64
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5fv0 ESSC

(Geobacillus
thermodenitrificans)
PF01580
(FtsK_SpoIIIE)
5 GLY A1261
ILE A1475
PHE A1464
GLN A1471
ILE A1258
None
0.78A 4ax8A-5fv0A:
4.2
4ax8A-5fv0A:
21.11
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5hgq LYSINE--TRNA LIGASE

(Loa loa)
PF00152
(tRNA-synt_2)
PF01336
(tRNA_anti-codon)
5 GLY A  62
ILE A 113
PHE A  31
ILE A 114
ILE A 135
None
0.91A 4ax8A-5hgqA:
undetectable
4ax8A-5hgqA:
20.55
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5tfl CADHERIN-23

(Mus musculus)
no annotation 5 ALA A 779
ILE A 810
SER A 836
VAL A 835
ILE A 833
None
0.98A 4ax8A-5tflA:
undetectable
4ax8A-5tflA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5u03 CTP SYNTHASE 1

(Homo sapiens)
PF00117
(GATase)
PF06418
(CTP_synth_N)
5 GLY A  15
ILE A  18
ILE A  19
SER A 181
VAL A 180
ATP  A 601 (-3.5A)
ATP  A 601 (-4.0A)
None
None
None
0.93A 4ax8A-5u03A:
undetectable
4ax8A-5u03A:
21.69
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5u03 CTP SYNTHASE 1

(Homo sapiens)
PF00117
(GATase)
PF06418
(CTP_synth_N)
5 GLY A  15
ILE A  18
SER A 181
VAL A 180
ILE A 178
ATP  A 601 (-3.5A)
ATP  A 601 (-4.0A)
None
None
None
1.00A 4ax8A-5u03A:
undetectable
4ax8A-5u03A:
21.69
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5uf8 POTENTIAL
ADP-RIBOSYLATION
FACTOR


(Candida
albicans)
PF00025
(Arf)
5 GLY A  29
ALA A  27
ILE A  33
VAL A  91
ILE A  89
GDP  A 500 (-3.2A)
GDP  A 500 (-4.2A)
None
None
None
0.83A 4ax8A-5uf8A:
undetectable
4ax8A-5uf8A:
15.21
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5wi5 UDP-N-ACETYLGLUCOSAM
INE
1-CARBOXYVINYLTRANSF
ERASE 1


(Streptococcus
pneumoniae)
PF00275
(EPSP_synthase)
5 GLY A 384
ALA A 387
ILE A 381
VAL A   6
ILE A   4
None
0.99A 4ax8A-5wi5A:
2.6
4ax8A-5wi5A:
22.57
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5z9s GLYCOSYL HYDROLASE
FAMILY 3 PROTEIN


(Bifidobacterium
longum)
no annotation 5 GLY A 463
ILE A 498
GLN A 537
VAL A 408
ILE A 511
None
0.93A 4ax8A-5z9sA:
undetectable
4ax8A-5z9sA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5znn SORTILIN

(Mus musculus)
no annotation 5 GLY A 529
ILE A 531
ASN A 651
ILE A 532
ILE A 505
None
0.83A 4ax8A-5znnA:
undetectable
4ax8A-5znnA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6bbp CYTOHESIN-3,ADP-RIBO
SYLATION FACTOR 6


(Homo sapiens;
Mus musculus)
no annotation 5 GLY A 423
ALA A 421
ILE A 427
VAL A 485
ILE A 483
GTP  A 601 (-3.3A)
GTP  A 601 (-4.2A)
None
None
None
0.83A 4ax8A-6bbpA:
3.0
4ax8A-6bbpA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6epi ZETA_1 TOXIN

(Neisseria
gonorrhoeae)
no annotation 5 GLY B 374
ILE B 339
ILE B 373
VAL B 313
ILE B 311
None
0.85A 4ax8A-6epiB:
2.1
4ax8A-6epiB:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6exs PEPTIDE ABC
TRANSPORTER PERMEASE


(Staphylococcus
hominis)
no annotation 5 GLY A 102
ALA A  98
ASN A 139
ILE A 106
ILE A 129
None
0.96A 4ax8A-6exsA:
undetectable
4ax8A-6exsA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6fae ADP-RIBOSYLATION
FACTOR 1


(Homo sapiens)
no annotation 5 GLY B  29
ALA B  27
ILE B  33
VAL B  91
ILE B  89
None
0.85A 4ax8A-6faeB:
2.1
4ax8A-6faeB:
undetectable