SIMILAR PATTERNS OF AMINO ACIDS FOR 4AX8_A_SAMA1474_0
List of similar pattern of amino acids derived from ASSAM searchHit | Macromolecule/ Organism |
Pfam | Res. | Interface | HETATM | RMSD | Dali Z-score | Seq. Identity (%) | View | Dock | |
---|---|---|---|---|---|---|---|---|---|---|---|
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 1cen | CELLULASE CELC (Ruminiclostridiumthermocellum) |
PF00150(Cellulase) | 5 | ASN A 82ILE A 37VAL A 45HIS A 44ILE A 8 | None | 0.98A | 4ax8A-1cenA:2.5 | 4ax8A-1cenA:20.57 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 1dy6 | CARBAPENEM-HYDROLYSING BETA-LACTAMASESME-1 (Serratiamarcescens) |
PF13354(Beta-lactamase2) | 5 | ARG A 256ILE A 250SER A 262VAL A 261ILE A 287 | None | 0.97A | 4ax8A-1dy6A:undetectable | 4ax8A-1dy6A:18.95 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 1ebd | DIHYDROLIPOAMIDEDEHYDROGENASE (Geobacillusstearothermophilus) |
PF02852(Pyr_redox_dim)PF07992(Pyr_redox_2) | 5 | GLY A 192ALA A 194ASN A 197ILE A 204ILE A 211 | None | 0.85A | 4ax8A-1ebdA:4.6 | 4ax8A-1ebdA:22.49 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 1fep | FERRIC ENTEROBACTINRECEPTOR (Escherichiacoli) |
PF00593(TonB_dep_Rec)PF07715(Plug) | 5 | ASN A 230ILE A 119SER A 46VAL A 45ILE A 36 | None | 0.97A | 4ax8A-1fepA:undetectable | 4ax8A-1fepA:21.47 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 1hq0 | CYTOTOXICNECROTIZING FACTOR 1 (Escherichiacoli) |
PF05785(CNF1) | 5 | GLY A 842ILE A 843SER A 834VAL A 833ILE A 831 | NoneNonePO4 A 302 ( 4.5A)NoneNone | 0.94A | 4ax8A-1hq0A:undetectable | 4ax8A-1hq0A:19.28 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 1hq0 | CYTOTOXICNECROTIZING FACTOR 1 (Escherichiacoli) |
PF05785(CNF1) | 5 | GLY A 842ILE A 843SER A 834VAL A 833ILE A 858 | NoneNonePO4 A 302 ( 4.5A)NoneNone | 0.94A | 4ax8A-1hq0A:undetectable | 4ax8A-1hq0A:19.28 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 1kkr | 3-METHYLASPARTATEAMMONIA-LYASE (Citrobacteramalonaticus) |
PF05034(MAAL_N)PF07476(MAAL_C) | 6 | GLY A 274ILE A 304GLN A 329ILE A 272HIS A 194ILE A 237 | NoneNone2AS A 801 (-3.5A)None2AS A 801 (-3.8A)None | 1.22A | 4ax8A-1kkrA:undetectable | 4ax8A-1kkrA:23.16 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 1kkr | 3-METHYLASPARTATEAMMONIA-LYASE (Citrobacteramalonaticus) |
PF05034(MAAL_N)PF07476(MAAL_C) | 6 | GLY A 274ILE A 304GLN A 329ILE A 272VAL A 239ILE A 237 | NoneNone2AS A 801 (-3.5A)NoneNoneNone | 1.19A | 4ax8A-1kkrA:undetectable | 4ax8A-1kkrA:23.16 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 1lml | LEISHMANOLYSIN (Leishmaniamajor) |
PF01457(Peptidase_M8) | 5 | ALA A 486ILE A 490SER A 523VAL A 524ILE A 556 | None | 0.97A | 4ax8A-1lmlA:undetectable | 4ax8A-1lmlA:21.11 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 1q5a | EP-CADHERIN (Mus musculus) |
PF00028(Cadherin) | 5 | GLY A 115ILE A 208ILE A 209VAL A 127ILE A 172 | NoneNAG A 801 ( 4.7A)NoneNoneNone | 0.24A | 4ax8A-1q5aA:undetectable | 4ax8A-1q5aA:20.38 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 1rf5 | 5-ENOLPYRUVYLSHIKIMATE-3-PHOSPHATESYNTHASE (Streptococcuspneumoniae) |
PF00275(EPSP_synthase) | 6 | GLY A 30ALA A 33ILE A 28ILE A 27VAL A 71ILE A 69 | None | 1.04A | 4ax8A-1rf5A:undetectable | 4ax8A-1rf5A:21.60 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 1wa5 | IMPORTIN ALPHASUBUNIT (Saccharomycescerevisiae) |
PF00514(Arm)PF01749(IBB)PF16186(Arm_3) | 5 | ILE B 477ILE B 455SER B 426VAL B 425ILE B 421 | None | 1.00A | 4ax8A-1wa5B:undetectable | 4ax8A-1wa5B:22.58 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 1wuf | HYPOTHETICAL PROTEINLIN2664 (Listeriainnocua) |
PF02746(MR_MLE_N)PF13378(MR_MLE_C) | 5 | GLY A1046ILE A1034ILE A1033VAL A1297ILE A1328 | None | 0.95A | 4ax8A-1wufA:undetectable | 4ax8A-1wufA:21.96 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 1z6x | ADP-RIBOSYLATIONFACTOR 4 (Homo sapiens) |
PF00025(Arf) | 5 | GLY A 29ALA A 27ILE A 33VAL A 91ILE A 89 | GDP A 201 (-3.0A)GDP A 201 (-4.1A)NoneNoneNone | 0.87A | 4ax8A-1z6xA:2.5 | 4ax8A-1z6xA:14.39 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 2e5f | HYPOTHETICAL PROTEINPH0510 (Pyrococcushorikoshii) |
PF01380(SIS) | 5 | GLY A 13ILE A 15ILE A 14SER A 138ILE A 292 | None | 0.81A | 4ax8A-2e5fA:3.6 | 4ax8A-2e5fA:21.54 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 2ji9 | OXALYL-COADECARBOXYLASE (Oxalobacterformigenes) |
PF00205(TPP_enzyme_M)PF02775(TPP_enzyme_C)PF02776(TPP_enzyme_N) | 6 | ALA A 235ILE A 218ILE A 279SER A 331VAL A 330ILE A 326 | NoneNoneNoneNoneNoneADP A1556 (-4.0A) | 1.26A | 4ax8A-2ji9A:2.6 | 4ax8A-2ji9A:22.31 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 2m71 | TRANSLATIONINITIATION FACTORIF-3 (Campylobacterjejuni) |
PF00707(IF3_C) | 5 | GLY A 56ALA A 55PHE A 79SER A 14VAL A 43 | None | 0.98A | 4ax8A-2m71A:3.9 | 4ax8A-2m71A:10.52 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 2nzu | CATABOLITE CONTROLPROTEIN (Bacillusmegaterium) |
PF13377(Peripla_BP_3) | 5 | GLY G 226ILE G 227SER G 184VAL G 183ILE G 243 | None | 0.89A | 4ax8A-2nzuG:3.3 | 4ax8A-2nzuG:19.06 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 2p8j | S-ADENOSYLMETHIONINE-DEPENDENTMETHYLTRANSFERASE (Clostridiumacetobutylicum) |
PF08241(Methyltransf_11) | 5 | GLY A 30ILE A 51GLN A 57ILE A 79HIS A 100 | GOL A 213 ( 3.7A)NoneNoneGOL A 213 ( 4.6A)None | 0.99A | 4ax8A-2p8jA:14.9 | 4ax8A-2p8jA:16.05 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 2po2 | PROBABLE EXOSOMECOMPLEX EXONUCLEASE2 (Pyrococcusabyssi) |
PF01138(RNase_PH)PF03725(RNase_PH_C) | 5 | ILE B 158ASN B 163ILE B 155VAL B 52ILE B 36 | None | 0.92A | 4ax8A-2po2B:undetectable | 4ax8A-2po2B:20.67 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 2v0j | BIFUNCTIONAL PROTEINGLMU (Haemophilusinfluenzae) |
PF00132(Hexapep)PF12804(NTP_transf_3) | 5 | GLY A 321ALA A 340ILE A 319VAL A 307ILE A 309 | None | 0.99A | 4ax8A-2v0jA:undetectable | 4ax8A-2v0jA:22.50 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 2v1o | CYTOSOLIC ACYLCOENZYME A THIOESTERHYDROLASE (Mus musculus) |
PF03061(4HBT) | 5 | GLY A 42ILE A 44ILE A 45VAL A 96ILE A 86 | None | 0.92A | 4ax8A-2v1oA:undetectable | 4ax8A-2v1oA:14.00 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 2vo1 | CTP SYNTHASE 1 (Homo sapiens) |
PF06418(CTP_synth_N) | 6 | GLY A 15ILE A 18ILE A 19SER A 181VAL A 180ILE A 178 | SO4 A1273 (-3.1A)NoneNoneNoneNoneNone | 0.85A | 4ax8A-2vo1A:undetectable | 4ax8A-2vo1A:19.21 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 2vo1 | CTP SYNTHASE 1 (Homo sapiens) |
PF06418(CTP_synth_N) | 6 | ILE A 18ILE A 19SER A 181VAL A 180HIS A 179ILE A 178 | None | 1.25A | 4ax8A-2vo1A:undetectable | 4ax8A-2vo1A:19.21 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 2wbn | TERMINASE LARGESUBUNIT (Bacillus phageSPP1) |
PF17288(Terminase_3C) | 5 | GLY A 264ALA A 404ILE A 319PHE A 409ILE A 261 | None | 0.84A | 4ax8A-2wbnA:undetectable | 4ax8A-2wbnA:17.10 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 2wfi | PEPTIDYL-PROLYLCIS-TRANS ISOMERASEG (Homo sapiens) |
PF00160(Pro_isomerase) | 5 | GLY A 22GLN A 19ILE A 14VAL A 150ILE A 154 | None | 0.99A | 4ax8A-2wfiA:undetectable | 4ax8A-2wfiA:16.73 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 2xk0 | POLYCOMB PROTEIN PCL (Drosophilamelanogaster) |
no annotation | 6 | ALA A 23ILE A 43GLN A 45ILE A 52VAL A 28ILE A 30 | None | 1.43A | 4ax8A-2xk0A:undetectable | 4ax8A-2xk0A:8.89 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 2y6p | 3-DEOXY-MANNO-OCTULOSONATECYTIDYLYLTRANSFERASE (Aquifexaeolicus) |
PF02348(CTP_transf_3) | 5 | GLY A 171ILE A 89ARG A 3ILE A 90ILE A 104 | None | 0.86A | 4ax8A-2y6pA:undetectable | 4ax8A-2y6pA:17.36 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 2yk6 | CMP-N-ACETYLNEURAMINATE-BETA-GALACTOSAMIDE-ALPHA-2,3-SIALYLTRANSFERASE (Neisseriameningitidis) |
PF07922(Glyco_transf_52) | 5 | ALA A 325ILE A 299ILE A 303VAL A 334ILE A 307 | NoneCDP A1374 (-4.1A)NoneNoneNone | 0.99A | 4ax8A-2yk6A:2.1 | 4ax8A-2yk6A:20.87 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 2z8z | LIPASE (Pseudomonas sp.MIS38) |
PF00353(HemolysinCabind) | 5 | GLY A 321ALA A 317ILE A 325VAL A 342ILE A 340 | None | 0.83A | 4ax8A-2z8zA:undetectable | 4ax8A-2z8zA:22.42 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3aq4 | ADP-RIBOSYLATIONFACTOR 1 (Arabidopsisthaliana) |
PF00025(Arf) | 5 | GLY A 29ALA A 27ILE A 33VAL A 91ILE A 89 | GDP A 183 (-3.3A)GDP A 183 (-4.3A)NoneNoneNone | 0.87A | 4ax8A-3aq4A:undetectable | 4ax8A-3aq4A:15.04 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3bxz | PREPROTEINTRANSLOCASE SUBUNITSECA (Escherichiacoli) |
PF07517(SecA_DEAD) | 6 | ALA A 503ILE A 557ILE A 442VAL A 500HIS A 476ILE A 474 | None | 1.43A | 4ax8A-3bxzA:3.3 | 4ax8A-3bxzA:22.71 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3e11 | PREDICTEDZINCIN-LIKEMETALLOPROTEASE (Acidothermuscellulolyticus) |
PF06262(Zincin_1) | 5 | GLY A 46ILE A 69ILE A 68HIS A 99ILE A 97 | None | 0.90A | 4ax8A-3e11A:undetectable | 4ax8A-3e11A:13.20 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3ebv | CHINITASE A (Streptomycescoelicolor) |
PF00704(Glyco_hydro_18) | 5 | ALA A 29ILE A 32ILE A 33VAL A 26ILE A 23 | None | 0.96A | 4ax8A-3ebvA:undetectable | 4ax8A-3ebvA:18.65 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3h7t | GROUP 3 ALLERGENSMIPP-S YVT004A06 (Sarcoptesscabiei) |
PF00089(Trypsin) | 5 | GLY A 28ALA A 15ILE A 37VAL A 18ILE A 51 | None | 0.88A | 4ax8A-3h7tA:undetectable | 4ax8A-3h7tA:16.98 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3hxg | EUKARYOTICTRANSLATIONINITIATION FACTOR 4E (Schistosomamansoni) |
PF01652(IF4E) | 5 | GLY A 137ILE A 135SER A 150VAL A 151ILE A 165 | None | 0.99A | 4ax8A-3hxgA:undetectable | 4ax8A-3hxgA:15.82 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3ihl | CTP SYNTHASE 2 (Homo sapiens) |
PF06418(CTP_synth_N) | 6 | GLY A 15ILE A 18ILE A 19SER A 181VAL A 180ILE A 178 | ADP A 300 (-3.4A)ADP A 300 (-4.3A)NoneNoneNoneNone | 0.80A | 4ax8A-3ihlA:undetectable | 4ax8A-3ihlA:18.31 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3il3 | 3-OXOACYL-[ACYL-CARRIER-PROTEIN]SYNTHASE 3 (Haemophilusinfluenzae) |
PF08541(ACP_syn_III_C)PF08545(ACP_syn_III) | 5 | ALA A 58ILE A 165ASN A 61ILE A 73ILE A 100 | None | 0.93A | 4ax8A-3il3A:2.0 | 4ax8A-3il3A:21.68 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3lrp | ADP-RIBOSYLATIONFACTOR 1 (Plasmodiumfalciparum) |
PF00025(Arf) | 5 | GLY A 29ALA A 27ILE A 33VAL A 91ILE A 89 | GDP A 182 (-3.1A)GDP A 182 (-4.3A)NoneNoneNone | 0.92A | 4ax8A-3lrpA:3.3 | 4ax8A-3lrpA:14.52 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3lvr | ARF-GAP WITH SH3DOMAIN, ANK REPEATAND PHDOMAIN-CONTAININGPROTEIN 3,ADP-RIBOSYLATIONFACTOR 6 (Homo sapiens;syntheticconstruct) |
PF00025(Arf)PF01412(ArfGap)PF12796(Ank_2) | 5 | GLY E 25ALA E 23ILE E 29VAL E 87ILE E 85 | GDP E 737 (-3.2A)GDP E 737 ( 4.4A)NoneNoneNone | 0.86A | 4ax8A-3lvrE:3.0 | 4ax8A-3lvrE:23.13 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3m1r | FORMIMIDOYLGLUTAMASE (Bacillussubtilis) |
PF00491(Arginase) | 6 | GLY A 124ALA A 54ILE A 285ILE A 122VAL A 42ILE A 40 | None | 1.41A | 4ax8A-3m1rA:5.1 | 4ax8A-3m1rA:21.39 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3mst | PUTATIVE NITRATETRANSPORT PROTEIN (Thermoplasmavolcanium) |
PF12916(DUF3834) | 5 | GLY A 159ALA A 155ILE A 160VAL A 17ILE A 174 | NoneEDO A 233 (-3.8A)NoneNoneNone | 0.90A | 4ax8A-3mstA:undetectable | 4ax8A-3mstA:19.48 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3nzq | BIOSYNTHETICARGININEDECARBOXYLASE (Escherichiacoli) |
PF02784(Orn_Arg_deC_N) | 5 | ALA A 346ILE A 340ILE A 339VAL A 287ILE A 283 | None | 0.97A | 4ax8A-3nzqA:2.4 | 4ax8A-3nzqA:22.67 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3o47 | ADP-RIBOSYLATIONFACTORGTPASE-ACTIVATINGPROTEIN 1,ADP-RIBOSYLATIONFACTOR 1 (Homo sapiens) |
PF00025(Arf)PF01412(ArfGap) | 5 | GLY A 159ALA A 157ILE A 163VAL A 221ILE A 219 | GDP A 502 (-3.2A)GDP A 502 (-4.4A)NoneNoneNone | 0.84A | 4ax8A-3o47A:undetectable | 4ax8A-3o47A:21.95 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3pbp | NUCLEOPORINNUP116/NSP116 (Saccharomycescerevisiae) |
PF04096(Nucleoporin2) | 5 | GLY B1020ASN B 967ILE B1024VAL B 995ILE B1003 | None | 0.98A | 4ax8A-3pbpB:undetectable | 4ax8A-3pbpB:13.90 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3qi7 | PUTATIVETRANSCRIPTIONALREGULATOR (Clostridioidesdifficile) |
PF12683(DUF3798) | 5 | ILE A 100ILE A 103SER A 118VAL A 117ILE A 115 | None | 0.87A | 4ax8A-3qi7A:2.5 | 4ax8A-3qi7A:20.55 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3r38 | UDP-N-ACETYLGLUCOSAMINE1-CARBOXYVINYLTRANSFERASE 1 (Listeriamonocytogenes) |
PF00275(EPSP_synthase) | 5 | GLY A 380ALA A 383ILE A 377VAL A 6ILE A 4 | None | 0.99A | 4ax8A-3r38A:undetectable | 4ax8A-3r38A:24.87 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3rrw | THYLAKOID LUMENAL 29KDA PROTEIN,CHLOROPLASTIC (Arabidopsisthaliana) |
PF00141(peroxidase) | 5 | GLY A 57ILE A 59ILE A 102SER A 152ILE A 101 | NoneNoneNoneGOL A 273 ( 4.5A)None | 0.99A | 4ax8A-3rrwA:undetectable | 4ax8A-3rrwA:18.92 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3s7z | PUTATIVE ASPARTATERACEMASE (Salmonellaenterica) |
PF01177(Asp_Glu_race) | 5 | ALA A 170ILE A 178VAL A 200HIS A 203ILE A 207 | None | 0.89A | 4ax8A-3s7zA:undetectable | 4ax8A-3s7zA:20.32 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3t6c | PUTATIVE MAND FAMILYDEHYDRATASE (Pantoeaananatis) |
PF02746(MR_MLE_N)PF13378(MR_MLE_C) | 5 | GLY A 103ALA A 106ILE A 101VAL A 110ILE A 305 | None | 0.92A | 4ax8A-3t6cA:undetectable | 4ax8A-3t6cA:22.54 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3ulv | FAB12 HEAVY CHAIN (Homo sapiens) |
PF07654(C1-set)PF07686(V-set) | 5 | GLY D 37ALA D 100GLN D 6ILE D 73ILE D 71 | None | 0.91A | 4ax8A-3ulvD:undetectable | 4ax8A-3ulvD:17.74 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3v9f | TWO-COMPONENT SYSTEMSENSOR HISTIDINEKINASE/RESPONSEREGULATOR, HYBRID(ONE-COMPONENTSYSTEM) (Bacteroidesthetaiotaomicron) |
PF07494(Reg_prop)PF07495(Y_Y_Y) | 5 | GLY A 296ALA A 330ILE A 297ASN A 329ILE A 277 | None | 0.91A | 4ax8A-3v9fA:undetectable | 4ax8A-3v9fA:21.77 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3w1z | HEAT SHOCK PROTEIN16 (Schizosaccharomycespombe) |
PF00011(HSP20) | 5 | ALA A 108PHE A 17ILE A 104SER A 49ILE A 39 | None | 0.90A | 4ax8A-3w1zA:undetectable | 4ax8A-3w1zA:13.19 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3w25 | GLYCOSIDE HYDROLASEFAMILY 10 (Thermoanaerobacteriumsaccharolyticum) |
PF00331(Glyco_hydro_10) | 5 | ILE A 186PHE A 185ILE A 218VAL A 245ILE A 247 | None | 0.95A | 4ax8A-3w25A:undetectable | 4ax8A-3w25A:20.59 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4ads | PYRIDOXINEBIOSYNTHETIC ENZYMEPDX1 HOMOLOGUE,PUTATIVE (Plasmodiumberghei) |
PF01680(SOR_SNZ) | 6 | GLY A 217ALA A 155ILE A 218ILE A 160HIS A 166ILE A 164 | PO4 A 302 (-3.8A)PO4 A 302 ( 4.1A)NoneNoneNoneNone | 1.49A | 4ax8A-4adsA:undetectable | 4ax8A-4adsA:22.41 | ||
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target. | 4azv | WBDD (Escherichiacoli) |
PF00069(Pkinase)PF13847(Methyltransf_31) | 11 | GLY A 61ALA A 63ILE A 81PHE A 83GLN A 84ASN A 87ILE A 110SER A 129VAL A 130HIS A 133ILE A 134 | SAM A1474 (-3.2A)SAM A1474 (-3.0A)SAM A1474 ( 4.5A)SAM A1474 (-3.6A)SAM A1474 (-3.9A)SAM A1474 (-3.7A)SAM A1474 (-3.8A)SAM A1474 ( 4.5A)SAM A1474 ( 3.4A)SAM A1474 (-3.8A)SAM A1474 ( 4.8A) | 0.15A | 4ax8A-4azvA:53.3 | 4ax8A-4azvA:99.82 | ||
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target. | 4azv | WBDD (Escherichiacoli) |
PF00069(Pkinase)PF13847(Methyltransf_31) | 6 | GLY A 61ILE A 81ARG A 109ILE A 110VAL A 130ILE A 134 | SAM A1474 (-3.2A)SAM A1474 ( 4.5A)SAM A1474 (-4.8A)SAM A1474 (-3.8A)SAM A1474 ( 3.4A)SAM A1474 ( 4.8A) | 0.97A | 4ax8A-4azvA:53.3 | 4ax8A-4azvA:99.82 | ||
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target. | 4azw | WBDD (Escherichiacoli) |
PF00069(Pkinase)PF13847(Methyltransf_31) | 12 | GLY A 61ALA A 63ILE A 81PHE A 83GLN A 84ASN A 87ARG A 109ILE A 110SER A 129VAL A 130HIS A 133ILE A 134 | SAM A1451 (-3.6A)SAM A1451 (-3.7A)NoneSAM A1451 (-3.5A)SAM A1451 (-4.2A)SAM A1451 (-4.0A)SAM A1451 (-3.9A)SAM A1451 (-4.0A)SAM A1451 (-4.5A)SAM A1451 (-4.6A)NoneNone | 0.28A | 4ax8A-4azwA:51.5 | 4ax8A-4azwA:99.36 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4c2k | 3-KETOACYL-COATHIOLASE,MITOCHONDRIAL (Homo sapiens) |
PF00108(Thiolase_N)PF02803(Thiolase_C) | 5 | ILE A 262GLN A 104ASN A 101ILE A 279VAL A 391 | None | 0.94A | 4ax8A-4c2kA:undetectable | 4ax8A-4c2kA:22.20 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4de8 | CPS2A (Streptococcuspneumoniae) |
PF02916(DNA_PPF)PF03816(LytR_cpsA_psr) | 5 | ILE A 385GLN A 379SER A 231VAL A 230ILE A 228 | 0K3 A 501 ( 4.2A)NoneNoneNoneNone | 1.00A | 4ax8A-4de8A:undetectable | 4ax8A-4de8A:22.13 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4dsq | PEROXIREDOXIN TYPE-2 (Saccharomycescerevisiae) |
PF08534(Redoxin) | 5 | ILE A 51ILE A 50SER A 171VAL A 172HIS A 175 | None | 1.00A | 4ax8A-4dsqA:undetectable | 4ax8A-4dsqA:15.61 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4e7n | SNAKE-VENOMTHROMBIN-LIKE ENZYME (Gloydius halys) |
PF00089(Trypsin) | 5 | GLY A 142ILE A 144ILE A 16SER A 195ILE A 138 | None | 1.00A | 4ax8A-4e7nA:undetectable | 4ax8A-4e7nA:18.08 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4eht | ACTIVATOR OF2-HYDROXYISOCAPROYL-COA DEHYDRATASE (Clostridioidesdifficile) |
PF01869(BcrAD_BadFG) | 6 | GLY A 128ALA A 127ILE A 100SER A 199VAL A 197ILE A 98 | NoneSF4 A 301 ( 4.4A)NoneNoneNoneNone | 1.46A | 4ax8A-4ehtA:undetectable | 4ax8A-4ehtA:18.24 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4fcx | DNA REPAIR PROTEINRAD32 (Schizosaccharomycespombe) |
no annotation | 5 | GLN B 240ILE B 186SER B 170VAL B 169ILE B 167 | None | 0.94A | 4ax8A-4fcxB:undetectable | 4ax8A-4fcxB:22.28 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4fe4 | XYLOSE OPERONREGULATORY PROTEIN (Escherichiacoli) |
PF12833(HTH_18)PF13377(Peripla_BP_3) | 5 | GLY A 186ALA A 123ILE A 216PHE A 111VAL A 119 | None | 0.95A | 4ax8A-4fe4A:3.5 | 4ax8A-4fe4A:21.69 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4fme | ADP-RIBOSYLATIONFACTOR 6 (Homo sapiens) |
PF00025(Arf) | 5 | GLY C 25ALA C 23ILE C 29VAL C 87ILE C 85 | GTP C 201 (-3.0A)GTP C 201 (-4.5A)NoneNoneNone | 0.89A | 4ax8A-4fmeC:undetectable | 4ax8A-4fmeC:14.47 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4h6x | THIAZOLINEOXIDASE/SUBTILISIN-LIKE PROTEASE (Prochlorondidemni) |
PF00082(Peptidase_S8) | 5 | ALA A 785ILE A 792SER A 713VAL A 712ILE A 679 | None | 0.99A | 4ax8A-4h6xA:undetectable | 4ax8A-4h6xA:19.75 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4ihc | MANDELATERACEMASE/MUCONATELACTONIZING PROTEIN (Dickeyaparadisiaca) |
PF02746(MR_MLE_N)PF13378(MR_MLE_C) | 5 | GLY A 103ALA A 106ILE A 101VAL A 110ILE A 305 | None | 0.94A | 4ax8A-4ihcA:2.3 | 4ax8A-4ihcA:23.14 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4ilr | CRISPR-ASSOCIATEDENDORIBONUCLEASECAS6 2 (Sulfolobussolfataricus) |
PF10040(CRISPR_Cas6) | 5 | GLY A 271ILE A 53PHE A 54ILE A 55HIS A 57 | None | 0.99A | 4ax8A-4ilrA:undetectable | 4ax8A-4ilrA:17.71 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4lgi | UNCHARACTERIZEDPROTEIN (Escherichiacoli) |
PF13678(Peptidase_M85) | 5 | ILE A 182ILE A 185SER A 162VAL A 161ILE A 108 | None | 0.96A | 4ax8A-4lgiA:undetectable | 4ax8A-4lgiA:19.47 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4mio | INOSITOL2-DEHYDROGENASE/D-CHIRO-INOSITOL3-DEHYDROGENASE (Lactobacilluscasei) |
PF01408(GFO_IDH_MocA) | 5 | GLY A 14ALA A 12ILE A 18VAL A 73ILE A 8 | NoneNAI A 401 (-3.6A)NoneNAI A 401 (-4.6A)None | 0.96A | 4ax8A-4mioA:5.2 | 4ax8A-4mioA:19.90 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4mz0 | CURL (Mooreaproducens) |
PF00109(ketoacyl-synt)PF00698(Acyl_transf_1)PF02801(Ketoacyl-synt_C)PF16197(KAsynt_C_assoc) | 5 | GLY A 393ALA A 389SER A 447VAL A 446ILE A 460 | None | 0.95A | 4ax8A-4mz0A:undetectable | 4ax8A-4mz0A:21.35 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4oja | SUPEROXIDE DISMUTASE[CU-ZN] (Hydra vulgaris) |
PF00080(Sod_Cu) | 6 | GLY A 43ALA A 139GLN A 120ASN A 121ILE A 86ILE A 33 | None | 1.24A | 4ax8A-4ojaA:undetectable | 4ax8A-4ojaA:14.41 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4pzv | 2-AMINO-4-HYDROXY-6-HYDROXYMETHYLDIHYDROPTERIDINEPYROPHOSPHOKINASE/DIHYDROPTEROATESYNTHASE (Francisellatularensis) |
PF00809(Pterin_bind)PF01288(HPPK) | 5 | ALA A 168ASN A 169ILE A 18SER A 38ILE A 7 | None | 0.94A | 4ax8A-4pzvA:undetectable | 4ax8A-4pzvA:21.02 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4rvh | D-MYCAROSE3-C-METHYLTRANSFERASE (Streptomycesargillaceus) |
PF08421(Methyltransf_13)PF08484(Methyltransf_14)PF13489(Methyltransf_23) | 5 | GLY A 114ILE A 134VAL A 179HIS A 182ILE A 183 | SAH A 502 (-3.5A)NoneSAH A 502 (-4.2A)3YN A 503 (-3.9A)SAH A 502 (-4.2A) | 0.70A | 4ax8A-4rvhA:12.6 | 4ax8A-4rvhA:21.75 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4xni | DI-OR TRIPEPTIDE:H+SYMPORTER (Streptococcusthermophilus) |
PF00854(PTR2) | 5 | GLY A 91ALA A 87ASN A 128ILE A 95ILE A 118 | None | 0.98A | 4ax8A-4xniA:undetectable | 4ax8A-4xniA:22.46 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4ylg | ADP-RIBOSYLATIONFACTOR (Entamoebahistolytica) |
PF00025(Arf) | 5 | GLY A 25ALA A 23ILE A 29VAL A 87ILE A 85 | GDP A 201 (-3.3A)GDP A 201 (-4.2A)NoneNoneNone | 0.86A | 4ax8A-4ylgA:undetectable | 4ax8A-4ylgA:15.28 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4z0z | AURONE SYNTHASE (Coreopsisgrandiflora) |
PF00264(Tyrosinase)PF12142(PPO1_DWL) | 5 | GLN A 203ASN A 207ILE A 160HIS A 181ILE A 182 | None | 0.94A | 4ax8A-4z0zA:undetectable | 4ax8A-4z0zA:18.29 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4zv3 | CYTOSOLIC ACYLCOENZYME A THIOESTERHYDROLASE (Mus musculus) |
PF03061(4HBT) | 5 | GLY A 88ILE A 90ILE A 91VAL A 142ILE A 132 | None | 0.94A | 4ax8A-4zv3A:undetectable | 4ax8A-4zv3A:17.50 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 5c1e | PECTINESTERASE (Aspergillusniger) |
PF01095(Pectinesterase) | 5 | ILE A 228ASN A 230ILE A 258VAL A 309ILE A 305 | None | 0.99A | 4ax8A-5c1eA:undetectable | 4ax8A-5c1eA:19.82 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 5cyx | PROTEIN CDHR2 (Mus musculus) |
PF00028(Cadherin) | 5 | ALA A 234ARG A 322ILE A 321SER A 239VAL A 240 | None | 1.00A | 4ax8A-5cyxA:undetectable | 4ax8A-5cyxA:19.34 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 5dds | CRMG (Actinoalloteichussp. WH1-2216-6) |
PF00202(Aminotran_3) | 5 | GLY A 322ALA A 326ILE A 321ILE A 59VAL A 403 | None | 1.00A | 4ax8A-5ddsA:undetectable | 4ax8A-5ddsA:22.56 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 5e6k | POLYKETIDE SYNTHASEPKSL (Bacillussubtilis) |
PF00109(ketoacyl-synt)PF02801(Ketoacyl-synt_C)PF16197(KAsynt_C_assoc) | 5 | GLY A 353ALA A 349SER A 408VAL A 407ILE A 421 | None | 0.97A | 4ax8A-5e6kA:undetectable | 4ax8A-5e6kA:23.68 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 5eny | POLYKETIDE SYNTHASEPKSL (Bacillussubtilis) |
PF00109(ketoacyl-synt)PF02801(Ketoacyl-synt_C)PF16197(KAsynt_C_assoc) | 5 | GLY A 353ALA A 349SER A 408VAL A 407ILE A 421 | None | 0.96A | 4ax8A-5enyA:2.3 | 4ax8A-5enyA:22.21 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 5eoe | BETA-LACTAMASE (Pseudomonasaeruginosa) |
PF13354(Beta-lactamase2) | 5 | GLY A 51ILE A 26SER A 253VAL A 39ILE A 37 | None | 0.99A | 4ax8A-5eoeA:undetectable | 4ax8A-5eoeA:19.37 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 5feu | NOROXOMARITIDINE/NORCRAUGSODINEREDUCTASE (Narcissuspseudonarcissus) |
PF13561(adh_short_C2) | 5 | ILE A 261ILE A 203VAL A 158HIS A 159ILE A 160 | NoneNoneNoneNoneNAP A 301 (-4.3A) | 0.98A | 4ax8A-5feuA:7.5 | 4ax8A-5feuA:21.35 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 5ff9 | NOROXOMARITIDINE/NORCRAUGSODINEREDUCTASE (Narcissuspseudonarcissus) |
PF13561(adh_short_C2) | 5 | ILE A 261ILE A 203VAL A 158HIS A 159ILE A 160 | NoneNoneNoneNoneNAP A 301 (-4.3A) | 0.96A | 4ax8A-5ff9A:7.5 | 4ax8A-5ff9A:19.64 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 5fv0 | ESSC (Geobacillusthermodenitrificans) |
PF01580(FtsK_SpoIIIE) | 5 | GLY A1261ILE A1475PHE A1464GLN A1471ILE A1258 | None | 0.78A | 4ax8A-5fv0A:4.2 | 4ax8A-5fv0A:21.11 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 5hgq | LYSINE--TRNA LIGASE (Loa loa) |
PF00152(tRNA-synt_2)PF01336(tRNA_anti-codon) | 5 | GLY A 62ILE A 113PHE A 31ILE A 114ILE A 135 | None | 0.91A | 4ax8A-5hgqA:undetectable | 4ax8A-5hgqA:20.55 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 5tfl | CADHERIN-23 (Mus musculus) |
no annotation | 5 | ALA A 779ILE A 810SER A 836VAL A 835ILE A 833 | None | 0.98A | 4ax8A-5tflA:undetectable | 4ax8A-5tflA:undetectable | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 5u03 | CTP SYNTHASE 1 (Homo sapiens) |
PF00117(GATase)PF06418(CTP_synth_N) | 5 | GLY A 15ILE A 18ILE A 19SER A 181VAL A 180 | ATP A 601 (-3.5A)ATP A 601 (-4.0A)NoneNoneNone | 0.93A | 4ax8A-5u03A:undetectable | 4ax8A-5u03A:21.69 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 5u03 | CTP SYNTHASE 1 (Homo sapiens) |
PF00117(GATase)PF06418(CTP_synth_N) | 5 | GLY A 15ILE A 18SER A 181VAL A 180ILE A 178 | ATP A 601 (-3.5A)ATP A 601 (-4.0A)NoneNoneNone | 1.00A | 4ax8A-5u03A:undetectable | 4ax8A-5u03A:21.69 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 5uf8 | POTENTIALADP-RIBOSYLATIONFACTOR (Candidaalbicans) |
PF00025(Arf) | 5 | GLY A 29ALA A 27ILE A 33VAL A 91ILE A 89 | GDP A 500 (-3.2A)GDP A 500 (-4.2A)NoneNoneNone | 0.83A | 4ax8A-5uf8A:undetectable | 4ax8A-5uf8A:15.21 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 5wi5 | UDP-N-ACETYLGLUCOSAMINE1-CARBOXYVINYLTRANSFERASE 1 (Streptococcuspneumoniae) |
PF00275(EPSP_synthase) | 5 | GLY A 384ALA A 387ILE A 381VAL A 6ILE A 4 | None | 0.99A | 4ax8A-5wi5A:2.6 | 4ax8A-5wi5A:22.57 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 5z9s | GLYCOSYL HYDROLASEFAMILY 3 PROTEIN (Bifidobacteriumlongum) |
no annotation | 5 | GLY A 463ILE A 498GLN A 537VAL A 408ILE A 511 | None | 0.93A | 4ax8A-5z9sA:undetectable | 4ax8A-5z9sA:undetectable | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 5znn | SORTILIN (Mus musculus) |
no annotation | 5 | GLY A 529ILE A 531ASN A 651ILE A 532ILE A 505 | None | 0.83A | 4ax8A-5znnA:undetectable | 4ax8A-5znnA:undetectable | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 6bbp | CYTOHESIN-3,ADP-RIBOSYLATION FACTOR 6 (Homo sapiens;Mus musculus) |
no annotation | 5 | GLY A 423ALA A 421ILE A 427VAL A 485ILE A 483 | GTP A 601 (-3.3A)GTP A 601 (-4.2A)NoneNoneNone | 0.83A | 4ax8A-6bbpA:3.0 | 4ax8A-6bbpA:undetectable | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 6epi | ZETA_1 TOXIN (Neisseriagonorrhoeae) |
no annotation | 5 | GLY B 374ILE B 339ILE B 373VAL B 313ILE B 311 | None | 0.85A | 4ax8A-6epiB:2.1 | 4ax8A-6epiB:undetectable | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 6exs | PEPTIDE ABCTRANSPORTER PERMEASE (Staphylococcushominis) |
no annotation | 5 | GLY A 102ALA A 98ASN A 139ILE A 106ILE A 129 | None | 0.96A | 4ax8A-6exsA:undetectable | 4ax8A-6exsA:undetectable | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 6fae | ADP-RIBOSYLATIONFACTOR 1 (Homo sapiens) |
no annotation | 5 | GLY B 29ALA B 27ILE B 33VAL B 91ILE B 89 | None | 0.85A | 4ax8A-6faeB:2.1 | 4ax8A-6faeB:undetectable |