SIMILAR PATTERNS OF AMINO ACIDS FOR 4AX8_A_SAMA1474

List of similar pattern of amino acids derived from ASSAM search

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click link on the last column to view superposed patterns of amino acids in NGL viewer)
(Note that only 3-12 residue patterns can be used for ASSAM searches)
Filter list by:
Hit Macromolecule/
Organism		 Pfam Res. Interface HETATM RMSD Dali Z-score Seq. Identity (%) View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1cen CELLULASE CELC

(Ruminiclostridium
thermocellum) 		PF00150
(Cellulase) 		5 ASN A  82
ILE A  37
VAL A  45
HIS A  44
ILE A   8
 None
 0.98A 4ax8A-1cenA:
2.5		 4ax8A-1cenA:
20.57
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1dy6 CARBAPENEM-HYDROLYSI
NG BETA-LACTAMASE
SME-1

(Serratia
marcescens) 		PF13354
(Beta-lactamase2) 		5 ARG A 256
ILE A 250
SER A 262
VAL A 261
ILE A 287
 None
 0.97A 4ax8A-1dy6A:
undetectable		 4ax8A-1dy6A:
18.95
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ebd DIHYDROLIPOAMIDE
DEHYDROGENASE

(Geobacillus
stearothermophilus) 		PF02852
(Pyr_redox_dim)
PF07992
(Pyr_redox_2) 		5 GLY A 192
ALA A 194
ASN A 197
ILE A 204
ILE A 211
 None
 0.85A 4ax8A-1ebdA:
4.6		 4ax8A-1ebdA:
22.49
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1fep FERRIC ENTEROBACTIN
RECEPTOR

(Escherichia
coli) 		PF00593
(TonB_dep_Rec)
PF07715
(Plug) 		5 ASN A 230
ILE A 119
SER A  46
VAL A  45
ILE A  36
 None
 0.97A 4ax8A-1fepA:
undetectable		 4ax8A-1fepA:
21.47
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1hq0 CYTOTOXIC
NECROTIZING FACTOR 1

(Escherichia
coli) 		PF05785
(CNF1) 		5 GLY A 842
ILE A 843
SER A 834
VAL A 833
ILE A 831
 None
None
PO4  A 302 ( 4.5A)
None
None
 0.94A 4ax8A-1hq0A:
undetectable		 4ax8A-1hq0A:
19.28
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1hq0 CYTOTOXIC
NECROTIZING FACTOR 1

(Escherichia
coli) 		PF05785
(CNF1) 		5 GLY A 842
ILE A 843
SER A 834
VAL A 833
ILE A 858
 None
None
PO4  A 302 ( 4.5A)
None
None
 0.94A 4ax8A-1hq0A:
undetectable		 4ax8A-1hq0A:
19.28
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1kkr 3-METHYLASPARTATE
AMMONIA-LYASE

(Citrobacter
amalonaticus) 		PF05034
(MAAL_N)
PF07476
(MAAL_C) 		6 GLY A 274
ILE A 304
GLN A 329
ILE A 272
HIS A 194
ILE A 237
 None
None
2AS  A 801 (-3.5A)
None
2AS  A 801 (-3.8A)
None
 1.22A 4ax8A-1kkrA:
undetectable		 4ax8A-1kkrA:
23.16
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1kkr 3-METHYLASPARTATE
AMMONIA-LYASE

(Citrobacter
amalonaticus) 		PF05034
(MAAL_N)
PF07476
(MAAL_C) 		6 GLY A 274
ILE A 304
GLN A 329
ILE A 272
VAL A 239
ILE A 237
 None
None
2AS  A 801 (-3.5A)
None
None
None
 1.19A 4ax8A-1kkrA:
undetectable		 4ax8A-1kkrA:
23.16
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1lml LEISHMANOLYSIN

(Leishmania
major) 		PF01457
(Peptidase_M8) 		5 ALA A 486
ILE A 490
SER A 523
VAL A 524
ILE A 556
 None
 0.97A 4ax8A-1lmlA:
undetectable		 4ax8A-1lmlA:
21.11
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1q5a EP-CADHERIN

(Mus musculus) 		PF00028
(Cadherin) 		5 GLY A 115
ILE A 208
ILE A 209
VAL A 127
ILE A 172
 None
NAG  A 801 ( 4.7A)
None
None
None
 0.24A 4ax8A-1q5aA:
undetectable		 4ax8A-1q5aA:
20.38
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1rf5 5-ENOLPYRUVYLSHIKIMA
TE-3-PHOSPHATE
SYNTHASE

(Streptococcus
pneumoniae) 		PF00275
(EPSP_synthase) 		6 GLY A  30
ALA A  33
ILE A  28
ILE A  27
VAL A  71
ILE A  69
 None
 1.04A 4ax8A-1rf5A:
undetectable		 4ax8A-1rf5A:
21.60
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1wa5 IMPORTIN ALPHA
SUBUNIT

(Saccharomyces
cerevisiae) 		PF00514
(Arm)
PF01749
(IBB)
PF16186
(Arm_3) 		5 ILE B 477
ILE B 455
SER B 426
VAL B 425
ILE B 421
 None
 1.00A 4ax8A-1wa5B:
undetectable		 4ax8A-1wa5B:
22.58
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1wuf HYPOTHETICAL PROTEIN
LIN2664

(Listeria
innocua) 		PF02746
(MR_MLE_N)
PF13378
(MR_MLE_C) 		5 GLY A1046
ILE A1034
ILE A1033
VAL A1297
ILE A1328
 None
 0.95A 4ax8A-1wufA:
undetectable		 4ax8A-1wufA:
21.96
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1z6x ADP-RIBOSYLATION
FACTOR 4

(Homo sapiens) 		PF00025
(Arf) 		5 GLY A  29
ALA A  27
ILE A  33
VAL A  91
ILE A  89
 GDP  A 201 (-3.0A)
GDP  A 201 (-4.1A)
None
None
None
 0.87A 4ax8A-1z6xA:
2.5		 4ax8A-1z6xA:
14.39
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2e5f HYPOTHETICAL PROTEIN
PH0510

(Pyrococcus
horikoshii) 		PF01380
(SIS) 		5 GLY A  13
ILE A  15
ILE A  14
SER A 138
ILE A 292
 None
 0.81A 4ax8A-2e5fA:
3.6		 4ax8A-2e5fA:
21.54
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2ji9 OXALYL-COA
DECARBOXYLASE

(Oxalobacter
formigenes) 		PF00205
(TPP_enzyme_M)
PF02775
(TPP_enzyme_C)
PF02776
(TPP_enzyme_N) 		6 ALA A 235
ILE A 218
ILE A 279
SER A 331
VAL A 330
ILE A 326
 None
None
None
None
None
ADP  A1556 (-4.0A)
 1.26A 4ax8A-2ji9A:
2.6		 4ax8A-2ji9A:
22.31
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2m71 TRANSLATION
INITIATION FACTOR
IF-3

(Campylobacter
jejuni) 		PF00707
(IF3_C) 		5 GLY A  56
ALA A  55
PHE A  79
SER A  14
VAL A  43
 None
 0.98A 4ax8A-2m71A:
3.9		 4ax8A-2m71A:
10.52
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2nzu CATABOLITE CONTROL
PROTEIN

(Bacillus
megaterium) 		PF13377
(Peripla_BP_3) 		5 GLY G 226
ILE G 227
SER G 184
VAL G 183
ILE G 243
 None
 0.89A 4ax8A-2nzuG:
3.3		 4ax8A-2nzuG:
19.06
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2p8j S-ADENOSYLMETHIONINE
-DEPENDENT
METHYLTRANSFERASE

(Clostridium
acetobutylicum) 		PF08241
(Methyltransf_11) 		5 GLY A  30
ILE A  51
GLN A  57
ILE A  79
HIS A 100
 GOL  A 213 ( 3.7A)
None
None
GOL  A 213 ( 4.6A)
None
 0.99A 4ax8A-2p8jA:
14.9		 4ax8A-2p8jA:
16.05
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2po2 PROBABLE EXOSOME
COMPLEX EXONUCLEASE
2

(Pyrococcus
abyssi) 		PF01138
(RNase_PH)
PF03725
(RNase_PH_C) 		5 ILE B 158
ASN B 163
ILE B 155
VAL B  52
ILE B  36
 None
 0.92A 4ax8A-2po2B:
undetectable		 4ax8A-2po2B:
20.67
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2v0j BIFUNCTIONAL PROTEIN
GLMU

(Haemophilus
influenzae) 		PF00132
(Hexapep)
PF12804
(NTP_transf_3) 		5 GLY A 321
ALA A 340
ILE A 319
VAL A 307
ILE A 309
 None
 0.99A 4ax8A-2v0jA:
undetectable		 4ax8A-2v0jA:
22.50
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2v1o CYTOSOLIC ACYL
COENZYME A THIOESTER
HYDROLASE

(Mus musculus) 		PF03061
(4HBT) 		5 GLY A  42
ILE A  44
ILE A  45
VAL A  96
ILE A  86
 None
 0.92A 4ax8A-2v1oA:
undetectable		 4ax8A-2v1oA:
14.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2vo1 CTP SYNTHASE 1

(Homo sapiens) 		PF06418
(CTP_synth_N) 		6 GLY A  15
ILE A  18
ILE A  19
SER A 181
VAL A 180
ILE A 178
 SO4  A1273 (-3.1A)
None
None
None
None
None
 0.85A 4ax8A-2vo1A:
undetectable		 4ax8A-2vo1A:
19.21
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2vo1 CTP SYNTHASE 1

(Homo sapiens) 		PF06418
(CTP_synth_N) 		6 ILE A  18
ILE A  19
SER A 181
VAL A 180
HIS A 179
ILE A 178
 None
 1.25A 4ax8A-2vo1A:
undetectable		 4ax8A-2vo1A:
19.21
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2wbn TERMINASE LARGE
SUBUNIT

(Bacillus phage
SPP1) 		PF17288
(Terminase_3C) 		5 GLY A 264
ALA A 404
ILE A 319
PHE A 409
ILE A 261
 None
 0.84A 4ax8A-2wbnA:
undetectable		 4ax8A-2wbnA:
17.10
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2wfi PEPTIDYL-PROLYL
CIS-TRANS ISOMERASE
G

(Homo sapiens) 		PF00160
(Pro_isomerase) 		5 GLY A  22
GLN A  19
ILE A  14
VAL A 150
ILE A 154
 None
 0.99A 4ax8A-2wfiA:
undetectable		 4ax8A-2wfiA:
16.73
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2xk0 POLYCOMB PROTEIN PCL

(Drosophila
melanogaster) 		no annotation 6 ALA A  23
ILE A  43
GLN A  45
ILE A  52
VAL A  28
ILE A  30
 None
 1.43A 4ax8A-2xk0A:
undetectable		 4ax8A-2xk0A:
8.89
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2y6p 3-DEOXY-MANNO-OCTULO
SONATE
CYTIDYLYLTRANSFERASE

(Aquifex
aeolicus) 		PF02348
(CTP_transf_3) 		5 GLY A 171
ILE A  89
ARG A   3
ILE A  90
ILE A 104
 None
 0.86A 4ax8A-2y6pA:
undetectable		 4ax8A-2y6pA:
17.36
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2yk6 CMP-N-ACETYLNEURAMIN
ATE-BETA-GALACTOSAMI
DE-ALPHA-2,3-SIALYLT
RANSFERASE

(Neisseria
meningitidis) 		PF07922
(Glyco_transf_52) 		5 ALA A 325
ILE A 299
ILE A 303
VAL A 334
ILE A 307
 None
CDP  A1374 (-4.1A)
None
None
None
 0.99A 4ax8A-2yk6A:
2.1		 4ax8A-2yk6A:
20.87
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2z8z LIPASE

(Pseudomonas sp.
MIS38) 		PF00353
(HemolysinCabind) 		5 GLY A 321
ALA A 317
ILE A 325
VAL A 342
ILE A 340
 None
 0.83A 4ax8A-2z8zA:
undetectable		 4ax8A-2z8zA:
22.42
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3aq4 ADP-RIBOSYLATION
FACTOR 1

(Arabidopsis
thaliana) 		PF00025
(Arf) 		5 GLY A  29
ALA A  27
ILE A  33
VAL A  91
ILE A  89
 GDP  A 183 (-3.3A)
GDP  A 183 (-4.3A)
None
None
None
 0.87A 4ax8A-3aq4A:
undetectable		 4ax8A-3aq4A:
15.04
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3bxz PREPROTEIN
TRANSLOCASE SUBUNIT
SECA

(Escherichia
coli) 		PF07517
(SecA_DEAD) 		6 ALA A 503
ILE A 557
ILE A 442
VAL A 500
HIS A 476
ILE A 474
 None
 1.43A 4ax8A-3bxzA:
3.3		 4ax8A-3bxzA:
22.71
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3e11 PREDICTED
ZINCIN-LIKE
METALLOPROTEASE

(Acidothermus
cellulolyticus) 		PF06262
(Zincin_1) 		5 GLY A  46
ILE A  69
ILE A  68
HIS A  99
ILE A  97
 None
 0.90A 4ax8A-3e11A:
undetectable		 4ax8A-3e11A:
13.20
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ebv CHINITASE A

(Streptomyces
coelicolor) 		PF00704
(Glyco_hydro_18) 		5 ALA A  29
ILE A  32
ILE A  33
VAL A  26
ILE A  23
 None
 0.96A 4ax8A-3ebvA:
undetectable		 4ax8A-3ebvA:
18.65
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3h7t GROUP 3 ALLERGEN
SMIPP-S YVT004A06

(Sarcoptes
scabiei) 		PF00089
(Trypsin) 		5 GLY A  28
ALA A  15
ILE A  37
VAL A  18
ILE A  51
 None
 0.88A 4ax8A-3h7tA:
undetectable		 4ax8A-3h7tA:
16.98
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3hxg EUKARYOTIC
TRANSLATION
INITIATION FACTOR 4E

(Schistosoma
mansoni) 		PF01652
(IF4E) 		5 GLY A 137
ILE A 135
SER A 150
VAL A 151
ILE A 165
 None
 0.99A 4ax8A-3hxgA:
undetectable		 4ax8A-3hxgA:
15.82
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ihl CTP SYNTHASE 2

(Homo sapiens) 		PF06418
(CTP_synth_N) 		6 GLY A  15
ILE A  18
ILE A  19
SER A 181
VAL A 180
ILE A 178
 ADP  A 300 (-3.4A)
ADP  A 300 (-4.3A)
None
None
None
None
 0.80A 4ax8A-3ihlA:
undetectable		 4ax8A-3ihlA:
18.31
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3il3 3-OXOACYL-[ACYL-CARR
IER-PROTEIN]
SYNTHASE 3

(Haemophilus
influenzae) 		PF08541
(ACP_syn_III_C)
PF08545
(ACP_syn_III) 		5 ALA A  58
ILE A 165
ASN A  61
ILE A  73
ILE A 100
 None
 0.93A 4ax8A-3il3A:
2.0		 4ax8A-3il3A:
21.68
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3lrp ADP-RIBOSYLATION
FACTOR 1

(Plasmodium
falciparum) 		PF00025
(Arf) 		5 GLY A  29
ALA A  27
ILE A  33
VAL A  91
ILE A  89
 GDP  A 182 (-3.1A)
GDP  A 182 (-4.3A)
None
None
None
 0.92A 4ax8A-3lrpA:
3.3		 4ax8A-3lrpA:
14.52
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3lvr ARF-GAP WITH SH3
DOMAIN, ANK REPEAT
AND PH
DOMAIN-CONTAINING
PROTEIN 3,
ADP-RIBOSYLATION
FACTOR 6

(Homo sapiens;
synthetic
construct) 		PF00025
(Arf)
PF01412
(ArfGap)
PF12796
(Ank_2) 		5 GLY E  25
ALA E  23
ILE E  29
VAL E  87
ILE E  85
 GDP  E 737 (-3.2A)
GDP  E 737 ( 4.4A)
None
None
None
 0.86A 4ax8A-3lvrE:
3.0		 4ax8A-3lvrE:
23.13
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3m1r FORMIMIDOYLGLUTAMASE

(Bacillus
subtilis) 		PF00491
(Arginase) 		6 GLY A 124
ALA A  54
ILE A 285
ILE A 122
VAL A  42
ILE A  40
 None
 1.41A 4ax8A-3m1rA:
5.1		 4ax8A-3m1rA:
21.39
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3mst PUTATIVE NITRATE
TRANSPORT PROTEIN

(Thermoplasma
volcanium) 		PF12916
(DUF3834) 		5 GLY A 159
ALA A 155
ILE A 160
VAL A  17
ILE A 174
 None
EDO  A 233 (-3.8A)
None
None
None
 0.90A 4ax8A-3mstA:
undetectable		 4ax8A-3mstA:
19.48
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3nzq BIOSYNTHETIC
ARGININE
DECARBOXYLASE

(Escherichia
coli) 		PF02784
(Orn_Arg_deC_N) 		5 ALA A 346
ILE A 340
ILE A 339
VAL A 287
ILE A 283
 None
 0.97A 4ax8A-3nzqA:
2.4		 4ax8A-3nzqA:
22.67
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3o47 ADP-RIBOSYLATION
FACTOR
GTPASE-ACTIVATING
PROTEIN 1,
ADP-RIBOSYLATION
FACTOR 1

(Homo sapiens) 		PF00025
(Arf)
PF01412
(ArfGap) 		5 GLY A 159
ALA A 157
ILE A 163
VAL A 221
ILE A 219
 GDP  A 502 (-3.2A)
GDP  A 502 (-4.4A)
None
None
None
 0.84A 4ax8A-3o47A:
undetectable		 4ax8A-3o47A:
21.95
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3pbp NUCLEOPORIN
NUP116/NSP116

(Saccharomyces
cerevisiae) 		PF04096
(Nucleoporin2) 		5 GLY B1020
ASN B 967
ILE B1024
VAL B 995
ILE B1003
 None
 0.98A 4ax8A-3pbpB:
undetectable		 4ax8A-3pbpB:
13.90
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3qi7 PUTATIVE
TRANSCRIPTIONAL
REGULATOR

(Clostridioides
difficile) 		PF12683
(DUF3798) 		5 ILE A 100
ILE A 103
SER A 118
VAL A 117
ILE A 115
 None
 0.87A 4ax8A-3qi7A:
2.5		 4ax8A-3qi7A:
20.55
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3r38 UDP-N-ACETYLGLUCOSAM
INE
1-CARBOXYVINYLTRANSF
ERASE 1

(Listeria
monocytogenes) 		PF00275
(EPSP_synthase) 		5 GLY A 380
ALA A 383
ILE A 377
VAL A   6
ILE A   4
 None
 0.99A 4ax8A-3r38A:
undetectable		 4ax8A-3r38A:
24.87
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3rrw THYLAKOID LUMENAL 29
KDA PROTEIN,
CHLOROPLASTIC

(Arabidopsis
thaliana) 		PF00141
(peroxidase) 		5 GLY A  57
ILE A  59
ILE A 102
SER A 152
ILE A 101
 None
None
None
GOL  A 273 ( 4.5A)
None
 0.99A 4ax8A-3rrwA:
undetectable		 4ax8A-3rrwA:
18.92
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3s7z PUTATIVE ASPARTATE
RACEMASE

(Salmonella
enterica) 		PF01177
(Asp_Glu_race) 		5 ALA A 170
ILE A 178
VAL A 200
HIS A 203
ILE A 207
 None
 0.89A 4ax8A-3s7zA:
undetectable		 4ax8A-3s7zA:
20.32
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3t6c PUTATIVE MAND FAMILY
DEHYDRATASE

(Pantoea
ananatis) 		PF02746
(MR_MLE_N)
PF13378
(MR_MLE_C) 		5 GLY A 103
ALA A 106
ILE A 101
VAL A 110
ILE A 305
 None
 0.92A 4ax8A-3t6cA:
undetectable		 4ax8A-3t6cA:
22.54
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ulv FAB12 HEAVY CHAIN

(Homo sapiens) 		PF07654
(C1-set)
PF07686
(V-set) 		5 GLY D  37
ALA D 100
GLN D   6
ILE D  73
ILE D  71
 None
 0.91A 4ax8A-3ulvD:
undetectable		 4ax8A-3ulvD:
17.74
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3v9f TWO-COMPONENT SYSTEM
SENSOR HISTIDINE
KINASE/RESPONSE
REGULATOR, HYBRID
(ONE-COMPONENT
SYSTEM)

(Bacteroides
thetaiotaomicron) 		PF07494
(Reg_prop)
PF07495
(Y_Y_Y) 		5 GLY A 296
ALA A 330
ILE A 297
ASN A 329
ILE A 277
 None
 0.91A 4ax8A-3v9fA:
undetectable		 4ax8A-3v9fA:
21.77
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3w1z HEAT SHOCK PROTEIN
16

(Schizosaccharomyces
pombe) 		PF00011
(HSP20) 		5 ALA A 108
PHE A  17
ILE A 104
SER A  49
ILE A  39
 None
 0.90A 4ax8A-3w1zA:
undetectable		 4ax8A-3w1zA:
13.19
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3w25 GLYCOSIDE HYDROLASE
FAMILY 10

(Thermoanaerobacterium
saccharolyticum) 		PF00331
(Glyco_hydro_10) 		5 ILE A 186
PHE A 185
ILE A 218
VAL A 245
ILE A 247
 None
 0.95A 4ax8A-3w25A:
undetectable		 4ax8A-3w25A:
20.59
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ads PYRIDOXINE
BIOSYNTHETIC ENZYME
PDX1 HOMOLOGUE,
PUTATIVE

(Plasmodium
berghei) 		PF01680
(SOR_SNZ) 		6 GLY A 217
ALA A 155
ILE A 218
ILE A 160
HIS A 166
ILE A 164
 PO4  A 302 (-3.8A)
PO4  A 302 ( 4.1A)
None
None
None
None
 1.49A 4ax8A-4adsA:
undetectable		 4ax8A-4adsA:
22.41
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4azv WBDD

(Escherichia
coli) 		PF00069
(Pkinase)
PF13847
(Methyltransf_31) 		11 GLY A  61
ALA A  63
ILE A  81
PHE A  83
GLN A  84
ASN A  87
ILE A 110
SER A 129
VAL A 130
HIS A 133
ILE A 134
 SAM  A1474 (-3.2A)
SAM  A1474 (-3.0A)
SAM  A1474 ( 4.5A)
SAM  A1474 (-3.6A)
SAM  A1474 (-3.9A)
SAM  A1474 (-3.7A)
SAM  A1474 (-3.8A)
SAM  A1474 ( 4.5A)
SAM  A1474 ( 3.4A)
SAM  A1474 (-3.8A)
SAM  A1474 ( 4.8A)
 0.15A 4ax8A-4azvA:
53.3		 4ax8A-4azvA:
99.82
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4azv WBDD

(Escherichia
coli) 		PF00069
(Pkinase)
PF13847
(Methyltransf_31) 		6 GLY A  61
ILE A  81
ARG A 109
ILE A 110
VAL A 130
ILE A 134
 SAM  A1474 (-3.2A)
SAM  A1474 ( 4.5A)
SAM  A1474 (-4.8A)
SAM  A1474 (-3.8A)
SAM  A1474 ( 3.4A)
SAM  A1474 ( 4.8A)
 0.97A 4ax8A-4azvA:
53.3		 4ax8A-4azvA:
99.82
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4azw WBDD

(Escherichia
coli) 		PF00069
(Pkinase)
PF13847
(Methyltransf_31) 		12 GLY A  61
ALA A  63
ILE A  81
PHE A  83
GLN A  84
ASN A  87
ARG A 109
ILE A 110
SER A 129
VAL A 130
HIS A 133
ILE A 134
 SAM  A1451 (-3.6A)
SAM  A1451 (-3.7A)
None
SAM  A1451 (-3.5A)
SAM  A1451 (-4.2A)
SAM  A1451 (-4.0A)
SAM  A1451 (-3.9A)
SAM  A1451 (-4.0A)
SAM  A1451 (-4.5A)
SAM  A1451 (-4.6A)
None
None
 0.28A 4ax8A-4azwA:
51.5		 4ax8A-4azwA:
99.36
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4c2k 3-KETOACYL-COA
THIOLASE,
MITOCHONDRIAL

(Homo sapiens) 		PF00108
(Thiolase_N)
PF02803
(Thiolase_C) 		5 ILE A 262
GLN A 104
ASN A 101
ILE A 279
VAL A 391
 None
 0.94A 4ax8A-4c2kA:
undetectable		 4ax8A-4c2kA:
22.20
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4de8 CPS2A

(Streptococcus
pneumoniae) 		PF02916
(DNA_PPF)
PF03816
(LytR_cpsA_psr) 		5 ILE A 385
GLN A 379
SER A 231
VAL A 230
ILE A 228
 0K3  A 501 ( 4.2A)
None
None
None
None
 1.00A 4ax8A-4de8A:
undetectable		 4ax8A-4de8A:
22.13
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4dsq PEROXIREDOXIN TYPE-2

(Saccharomyces
cerevisiae) 		PF08534
(Redoxin) 		5 ILE A  51
ILE A  50
SER A 171
VAL A 172
HIS A 175
 None
 1.00A 4ax8A-4dsqA:
undetectable		 4ax8A-4dsqA:
15.61
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4e7n SNAKE-VENOM
THROMBIN-LIKE ENZYME

(Gloydius halys) 		PF00089
(Trypsin) 		5 GLY A 142
ILE A 144
ILE A  16
SER A 195
ILE A 138
 None
 1.00A 4ax8A-4e7nA:
undetectable		 4ax8A-4e7nA:
18.08
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4eht ACTIVATOR OF
2-HYDROXYISOCAPROYL-
COA DEHYDRATASE

(Clostridioides
difficile) 		PF01869
(BcrAD_BadFG) 		6 GLY A 128
ALA A 127
ILE A 100
SER A 199
VAL A 197
ILE A  98
 None
SF4  A 301 ( 4.4A)
None
None
None
None
 1.46A 4ax8A-4ehtA:
undetectable		 4ax8A-4ehtA:
18.24
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4fcx DNA REPAIR PROTEIN
RAD32

(Schizosaccharomyces
pombe) 		no annotation 5 GLN B 240
ILE B 186
SER B 170
VAL B 169
ILE B 167
 None
 0.94A 4ax8A-4fcxB:
undetectable		 4ax8A-4fcxB:
22.28
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4fe4 XYLOSE OPERON
REGULATORY PROTEIN

(Escherichia
coli) 		PF12833
(HTH_18)
PF13377
(Peripla_BP_3) 		5 GLY A 186
ALA A 123
ILE A 216
PHE A 111
VAL A 119
 None
 0.95A 4ax8A-4fe4A:
3.5		 4ax8A-4fe4A:
21.69
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4fme ADP-RIBOSYLATION
FACTOR 6

(Homo sapiens) 		PF00025
(Arf) 		5 GLY C  25
ALA C  23
ILE C  29
VAL C  87
ILE C  85
 GTP  C 201 (-3.0A)
GTP  C 201 (-4.5A)
None
None
None
 0.89A 4ax8A-4fmeC:
undetectable		 4ax8A-4fmeC:
14.47
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4h6x THIAZOLINE
OXIDASE/SUBTILISIN-L
IKE PROTEASE

(Prochloron
didemni) 		PF00082
(Peptidase_S8) 		5 ALA A 785
ILE A 792
SER A 713
VAL A 712
ILE A 679
 None
 0.99A 4ax8A-4h6xA:
undetectable		 4ax8A-4h6xA:
19.75
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ihc MANDELATE
RACEMASE/MUCONATE
LACTONIZING PROTEIN

(Dickeya
paradisiaca) 		PF02746
(MR_MLE_N)
PF13378
(MR_MLE_C) 		5 GLY A 103
ALA A 106
ILE A 101
VAL A 110
ILE A 305
 None
 0.94A 4ax8A-4ihcA:
2.3		 4ax8A-4ihcA:
23.14
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ilr CRISPR-ASSOCIATED
ENDORIBONUCLEASE
CAS6 2

(Sulfolobus
solfataricus) 		PF10040
(CRISPR_Cas6) 		5 GLY A 271
ILE A  53
PHE A  54
ILE A  55
HIS A  57
 None
 0.99A 4ax8A-4ilrA:
undetectable		 4ax8A-4ilrA:
17.71
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4lgi UNCHARACTERIZED
PROTEIN

(Escherichia
coli) 		PF13678
(Peptidase_M85) 		5 ILE A 182
ILE A 185
SER A 162
VAL A 161
ILE A 108
 None
 0.96A 4ax8A-4lgiA:
undetectable		 4ax8A-4lgiA:
19.47
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4mio INOSITOL
2-DEHYDROGENASE/D-CH
IRO-INOSITOL
3-DEHYDROGENASE

(Lactobacillus
casei) 		PF01408
(GFO_IDH_MocA) 		5 GLY A  14
ALA A  12
ILE A  18
VAL A  73
ILE A   8
 None
NAI  A 401 (-3.6A)
None
NAI  A 401 (-4.6A)
None
 0.96A 4ax8A-4mioA:
5.2		 4ax8A-4mioA:
19.90
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4mz0 CURL

(Moorea
producens) 		PF00109
(ketoacyl-synt)
PF00698
(Acyl_transf_1)
PF02801
(Ketoacyl-synt_C)
PF16197
(KAsynt_C_assoc) 		5 GLY A 393
ALA A 389
SER A 447
VAL A 446
ILE A 460
 None
 0.95A 4ax8A-4mz0A:
undetectable		 4ax8A-4mz0A:
21.35
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4oja SUPEROXIDE DISMUTASE
[CU-ZN]

(Hydra vulgaris) 		PF00080
(Sod_Cu) 		6 GLY A  43
ALA A 139
GLN A 120
ASN A 121
ILE A  86
ILE A  33
 None
 1.24A 4ax8A-4ojaA:
undetectable		 4ax8A-4ojaA:
14.41
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4pzv 2-AMINO-4-HYDROXY-6-
HYDROXYMETHYLDIHYDRO
PTERIDINE
PYROPHOSPHOKINASE/DI
HYDROPTEROATE
SYNTHASE

(Francisella
tularensis) 		PF00809
(Pterin_bind)
PF01288
(HPPK) 		5 ALA A 168
ASN A 169
ILE A  18
SER A  38
ILE A   7
 None
 0.94A 4ax8A-4pzvA:
undetectable		 4ax8A-4pzvA:
21.02
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4rvh D-MYCAROSE
3-C-METHYLTRANSFERAS
E

(Streptomyces
argillaceus) 		PF08421
(Methyltransf_13)
PF08484
(Methyltransf_14)
PF13489
(Methyltransf_23) 		5 GLY A 114
ILE A 134
VAL A 179
HIS A 182
ILE A 183
 SAH  A 502 (-3.5A)
None
SAH  A 502 (-4.2A)
3YN  A 503 (-3.9A)
SAH  A 502 (-4.2A)
 0.70A 4ax8A-4rvhA:
12.6		 4ax8A-4rvhA:
21.75
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4xni DI-OR TRIPEPTIDE:H+
SYMPORTER

(Streptococcus
thermophilus) 		PF00854
(PTR2) 		5 GLY A  91
ALA A  87
ASN A 128
ILE A  95
ILE A 118
 None
 0.98A 4ax8A-4xniA:
undetectable		 4ax8A-4xniA:
22.46
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ylg ADP-RIBOSYLATION
FACTOR

(Entamoeba
histolytica) 		PF00025
(Arf) 		5 GLY A  25
ALA A  23
ILE A  29
VAL A  87
ILE A  85
 GDP  A 201 (-3.3A)
GDP  A 201 (-4.2A)
None
None
None
 0.86A 4ax8A-4ylgA:
undetectable		 4ax8A-4ylgA:
15.28
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4z0z AURONE SYNTHASE

(Coreopsis
grandiflora) 		PF00264
(Tyrosinase)
PF12142
(PPO1_DWL) 		5 GLN A 203
ASN A 207
ILE A 160
HIS A 181
ILE A 182
 None
 0.94A 4ax8A-4z0zA:
undetectable		 4ax8A-4z0zA:
18.29
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4zv3 CYTOSOLIC ACYL
COENZYME A THIOESTER
HYDROLASE

(Mus musculus) 		PF03061
(4HBT) 		5 GLY A  88
ILE A  90
ILE A  91
VAL A 142
ILE A 132
 None
 0.94A 4ax8A-4zv3A:
undetectable		 4ax8A-4zv3A:
17.50
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5c1e PECTINESTERASE

(Aspergillus
niger) 		PF01095
(Pectinesterase) 		5 ILE A 228
ASN A 230
ILE A 258
VAL A 309
ILE A 305
 None
 0.99A 4ax8A-5c1eA:
undetectable		 4ax8A-5c1eA:
19.82
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5cyx PROTEIN CDHR2

(Mus musculus) 		PF00028
(Cadherin) 		5 ALA A 234
ARG A 322
ILE A 321
SER A 239
VAL A 240
 None
 1.00A 4ax8A-5cyxA:
undetectable		 4ax8A-5cyxA:
19.34
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5dds CRMG

(Actinoalloteichus
sp. WH1-2216-6) 		PF00202
(Aminotran_3) 		5 GLY A 322
ALA A 326
ILE A 321
ILE A  59
VAL A 403
 None
 1.00A 4ax8A-5ddsA:
undetectable		 4ax8A-5ddsA:
22.56
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5e6k POLYKETIDE SYNTHASE
PKSL

(Bacillus
subtilis) 		PF00109
(ketoacyl-synt)
PF02801
(Ketoacyl-synt_C)
PF16197
(KAsynt_C_assoc) 		5 GLY A 353
ALA A 349
SER A 408
VAL A 407
ILE A 421
 None
 0.97A 4ax8A-5e6kA:
undetectable		 4ax8A-5e6kA:
23.68
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5eny POLYKETIDE SYNTHASE
PKSL

(Bacillus
subtilis) 		PF00109
(ketoacyl-synt)
PF02801
(Ketoacyl-synt_C)
PF16197
(KAsynt_C_assoc) 		5 GLY A 353
ALA A 349
SER A 408
VAL A 407
ILE A 421
 None
 0.96A 4ax8A-5enyA:
2.3		 4ax8A-5enyA:
22.21
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5eoe BETA-LACTAMASE

(Pseudomonas
aeruginosa) 		PF13354
(Beta-lactamase2) 		5 GLY A  51
ILE A  26
SER A 253
VAL A  39
ILE A  37
 None
 0.99A 4ax8A-5eoeA:
undetectable		 4ax8A-5eoeA:
19.37
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5feu NOROXOMARITIDINE/NOR
CRAUGSODINE
REDUCTASE

(Narcissus
pseudonarcissus) 		PF13561
(adh_short_C2) 		5 ILE A 261
ILE A 203
VAL A 158
HIS A 159
ILE A 160
 None
None
None
None
NAP  A 301 (-4.3A)
 0.98A 4ax8A-5feuA:
7.5		 4ax8A-5feuA:
21.35
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ff9 NOROXOMARITIDINE/NOR
CRAUGSODINE
REDUCTASE

(Narcissus
pseudonarcissus) 		PF13561
(adh_short_C2) 		5 ILE A 261
ILE A 203
VAL A 158
HIS A 159
ILE A 160
 None
None
None
None
NAP  A 301 (-4.3A)
 0.96A 4ax8A-5ff9A:
7.5		 4ax8A-5ff9A:
19.64
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5fv0 ESSC

(Geobacillus
thermodenitrificans) 		PF01580
(FtsK_SpoIIIE) 		5 GLY A1261
ILE A1475
PHE A1464
GLN A1471
ILE A1258
 None
 0.78A 4ax8A-5fv0A:
4.2		 4ax8A-5fv0A:
21.11
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5hgq LYSINE--TRNA LIGASE

(Loa loa) 		PF00152
(tRNA-synt_2)
PF01336
(tRNA_anti-codon) 		5 GLY A  62
ILE A 113
PHE A  31
ILE A 114
ILE A 135
 None
 0.91A 4ax8A-5hgqA:
undetectable		 4ax8A-5hgqA:
20.55
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5tfl CADHERIN-23

(Mus musculus) 		no annotation 5 ALA A 779
ILE A 810
SER A 836
VAL A 835
ILE A 833
 None
 0.98A 4ax8A-5tflA:
undetectable		 4ax8A-5tflA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5u03 CTP SYNTHASE 1

(Homo sapiens) 		PF00117
(GATase)
PF06418
(CTP_synth_N) 		5 GLY A  15
ILE A  18
ILE A  19
SER A 181
VAL A 180
 ATP  A 601 (-3.5A)
ATP  A 601 (-4.0A)
None
None
None
 0.93A 4ax8A-5u03A:
undetectable		 4ax8A-5u03A:
21.69
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5u03 CTP SYNTHASE 1

(Homo sapiens) 		PF00117
(GATase)
PF06418
(CTP_synth_N) 		5 GLY A  15
ILE A  18
SER A 181
VAL A 180
ILE A 178
 ATP  A 601 (-3.5A)
ATP  A 601 (-4.0A)
None
None
None
 1.00A 4ax8A-5u03A:
undetectable		 4ax8A-5u03A:
21.69
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5uf8 POTENTIAL
ADP-RIBOSYLATION
FACTOR

(Candida
albicans) 		PF00025
(Arf) 		5 GLY A  29
ALA A  27
ILE A  33
VAL A  91
ILE A  89
 GDP  A 500 (-3.2A)
GDP  A 500 (-4.2A)
None
None
None
 0.83A 4ax8A-5uf8A:
undetectable		 4ax8A-5uf8A:
15.21
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5wi5 UDP-N-ACETYLGLUCOSAM
INE
1-CARBOXYVINYLTRANSF
ERASE 1

(Streptococcus
pneumoniae) 		PF00275
(EPSP_synthase) 		5 GLY A 384
ALA A 387
ILE A 381
VAL A   6
ILE A   4
 None
 0.99A 4ax8A-5wi5A:
2.6		 4ax8A-5wi5A:
22.57
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5z9s GLYCOSYL HYDROLASE
FAMILY 3 PROTEIN

(Bifidobacterium
longum) 		no annotation 5 GLY A 463
ILE A 498
GLN A 537
VAL A 408
ILE A 511
 None
 0.93A 4ax8A-5z9sA:
undetectable		 4ax8A-5z9sA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5znn SORTILIN

(Mus musculus) 		no annotation 5 GLY A 529
ILE A 531
ASN A 651
ILE A 532
ILE A 505
 None
 0.83A 4ax8A-5znnA:
undetectable		 4ax8A-5znnA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6bbp CYTOHESIN-3,ADP-RIBO
SYLATION FACTOR 6

(Homo sapiens;
Mus musculus) 		no annotation 5 GLY A 423
ALA A 421
ILE A 427
VAL A 485
ILE A 483
 GTP  A 601 (-3.3A)
GTP  A 601 (-4.2A)
None
None
None
 0.83A 4ax8A-6bbpA:
3.0		 4ax8A-6bbpA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6epi ZETA_1 TOXIN

(Neisseria
gonorrhoeae) 		no annotation 5 GLY B 374
ILE B 339
ILE B 373
VAL B 313
ILE B 311
 None
 0.85A 4ax8A-6epiB:
2.1		 4ax8A-6epiB:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6exs PEPTIDE ABC
TRANSPORTER PERMEASE

(Staphylococcus
hominis) 		no annotation 5 GLY A 102
ALA A  98
ASN A 139
ILE A 106
ILE A 129
 None
 0.96A 4ax8A-6exsA:
undetectable		 4ax8A-6exsA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6fae ADP-RIBOSYLATION
FACTOR 1

(Homo sapiens) 		no annotation 5 GLY B  29
ALA B  27
ILE B  33
VAL B  91
ILE B  89
 None
 0.85A 4ax8A-6faeB:
2.1		 4ax8A-6faeB:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1d9s CYCLIN-DEPENDENT
KINASE 4 INHIBITOR B

(Mus musculus) 		PF12796
(Ank_2) 		4 ARG A  23
ASP A  86
GLU A  82
LEU A  56
 None
 1.24A 4ax8A-1d9sA:
0.0		 4ax8A-1d9sA:
15.32
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1e5i DEACETOXYCEPHALOSPOR
IN C SYNTHASE

(Streptomyces
clavuligerus) 		PF03171
(2OG-FeII_Oxy) 		4 ARG A 266
ASP A 107
GLU A 116
LEU A 158
 None
 1.19A 4ax8A-1e5iA:
0.0		 4ax8A-1e5iA:
18.37
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1fbv SIGNAL TRANSDUCTION
PROTEIN CBL

(Homo sapiens) 		PF02262
(Cbl_N)
PF02761
(Cbl_N2)
PF02762
(Cbl_N3)
PF14447
(Prok-RING_4) 		4 GLN A 316
ASP A 275
GLU A 143
LEU A 281
 None
 1.29A 4ax8A-1fbvA:
0.0		 4ax8A-1fbvA:
21.88
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1h31 DIHEME CYTOCHROME C

(Rhodovulum
sulfidophilum) 		no annotation 4 GLN A 196
ARG A 248
ASP A  29
LEU A  24
 None
 1.40A 4ax8A-1h31A:
0.0		 4ax8A-1h31A:
19.04
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1h6d PRECURSOR FORM OF
GLUCOSE-FRUCTOSE
OXIDOREDUCTASE

(Zymomonas
mobilis) 		PF01408
(GFO_IDH_MocA)
PF02894
(GFO_IDH_MocA_C) 		4 TYR A 412
GLN A 409
ARG A 255
GLU A 180
 None
None
None
NDP  A 500 (-3.2A)
 1.28A 4ax8A-1h6dA:
4.0		 4ax8A-1h6dA:
21.86
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1irx LYSYL-TRNA
SYNTHETASE

(Pyrococcus
horikoshii) 		PF01921
(tRNA-synt_1f) 		4 TYR A 424
ASP A 318
GLU A 329
LEU A 293
 None
 1.40A 4ax8A-1irxA:
2.6		 4ax8A-1irxA:
21.07
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1mio NITROGENASE
MOLYBDENUM IRON
PROTEIN (BETA CHAIN)

(Clostridium
pasteurianum) 		PF00148
(Oxidored_nitro) 		4 ARG B 189
ASP B 274
GLU B 282
LEU B 190
 None
 1.23A 4ax8A-1mioB:
0.6		 4ax8A-1mioB:
21.81
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1n21 (+)-BORNYL
DIPHOSPHATE SYNTHASE

(Salvia
officinalis) 		PF01397
(Terpene_synth)
PF03936
(Terpene_synth_C) 		4 GLN A 254
ASP A 120
GLU A 125
LEU A 116
 None
 1.10A 4ax8A-1n21A:
0.0		 4ax8A-1n21A:
22.35
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1qgr PROTEIN (IMPORTIN
BETA SUBUNIT)
PROTEIN (IMPORTIN
ALPHA-2 SUBUNIT)

(Homo sapiens;
Homo sapiens) 		PF03810
(IBN_N)
PF13513
(HEAT_EZ)
PF01749
(IBB) 		4 GLN A 589
ARG A 593
GLU A 760
LEU B  38
 None
 1.17A 4ax8A-1qgrA:
0.6		 4ax8A-1qgrA:
20.56
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1r4n AMYLOID BETA
PRECURSOR
PROTEIN-BINDING
PROTEIN 1

(Homo sapiens) 		PF00899
(ThiF) 		4 GLN A 343
ASP A 331
GLU A 263
LEU A 342
 None
 1.33A 4ax8A-1r4nA:
5.9		 4ax8A-1r4nA:
22.19
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1wao SERINE/THREONINE
PROTEIN PHOSPHATASE
5

(Homo sapiens) 		PF00149
(Metallophos)
PF00515
(TPR_1)
PF08321
(PPP5) 		4 TYR 1  78
ARG 1 275
ASP 1 388
GLU 1 435
 None
MN  1 602 ( 4.7A)
None
None
 1.37A 4ax8A-1wao1:
undetectable		 4ax8A-1wao1:
22.15
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1woy METHIONYL-TRNA
SYNTHETASE

(Thermus
thermophilus) 		PF00133
(tRNA-synt_1)
PF09334
(tRNA-synt_1g) 		4 TYR A  24
ASP A 260
GLU A 189
LEU A 256
 None
 1.37A 4ax8A-1woyA:
undetectable		 4ax8A-1woyA:
22.59
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1wz2 LEUCYL-TRNA
SYNTHETASE

(Pyrococcus
horikoshii) 		PF00133
(tRNA-synt_1)
PF08264
(Anticodon_1) 		4 GLN A 276
ARG A 256
ASP A 208
GLU A 425
 None
 1.11A 4ax8A-1wz2A:
undetectable		 4ax8A-1wz2A:
19.34
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1xrs D-LYSINE
5,6-AMINOMUTASE
ALPHA SUBUNIT

(Acetoanaerobium
sticklandii) 		PF09043
(Lys-AminoMut_A) 		4 TYR A 230
ARG A 217
ASP A 178
LEU A 233
 None
 1.14A 4ax8A-1xrsA:
undetectable		 4ax8A-1xrsA:
21.80
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1yxa SERINE (OR CYSTEINE)
PROTEINASE
INHIBITOR, CLADE A,
MEMBER 3N

(Mus musculus) 		PF00079
(Serpin) 		4 GLN A 169
ARG A 144
ASP A 198
GLU A 323
 None
 1.41A 4ax8A-1yxaA:
undetectable		 4ax8A-1yxaA:
23.08
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1zj9 PROBABLE
FERREDOXIN-DEPENDENT
NITRITE REDUCTASE
NIRA

(Mycobacterium
tuberculosis) 		PF01077
(NIR_SIR)
PF03460
(NIR_SIR_ferr) 		4 ARG A 433
ASP A 526
GLU A 446
LEU A 437
 None
 1.28A 4ax8A-1zj9A:
undetectable		 4ax8A-1zj9A:
23.48
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1zjj HYPOTHETICAL PROTEIN
PH1952

(Pyrococcus
horikoshii) 		PF13242
(Hydrolase_like)
PF13344
(Hydrolase_6) 		4 ARG A 112
ASP A 129
GLU A  92
LEU A 108
 None
 1.26A 4ax8A-1zjjA:
2.5		 4ax8A-1zjjA:
18.45
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2bb3 COBALAMIN
BIOSYNTHESIS
PRECORRIN-6Y
METHYLASE (CBIE)

(Archaeoglobus
fulgidus) 		PF00590
(TP_methylase) 		4 ARG A 173
ASP A 178
GLU A 194
LEU A 161
 None
 1.42A 4ax8A-2bb3A:
undetectable		 4ax8A-2bb3A:
19.48
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2cly ATP SYNTHASE B
CHAIN, MITOCHONDRIAL
ATP SYNTHASE D
CHAIN, MITOCHONDRIAL

(Bos taurus;
Bos taurus) 		PF05405
(Mt_ATP-synt_B)
PF05873
(Mt_ATP-synt_D) 		4 GLN B  23
ARG A 121
GLU B  35
LEU A 124
 None
 1.19A 4ax8A-2clyB:
undetectable		 4ax8A-2clyB:
14.26
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2dkk CYTOCHROME P450

(Streptomyces
coelicolor) 		PF00067
(p450) 		4 ARG A 363
ASP A 340
GLU A 265
LEU A 281
 None
 1.23A 4ax8A-2dkkA:
undetectable		 4ax8A-2dkkA:
22.42
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2fd5 TRANSCRIPTIONAL
REGULATOR

(Pseudomonas
aeruginosa) 		PF00440
(TetR_N) 		4 GLN A  18
ASP A 101
GLU A  72
LEU A  62
 None
 1.27A 4ax8A-2fd5A:
undetectable		 4ax8A-2fd5A:
17.31
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2gdu SUCROSE
PHOSPHORYLASE

(Bifidobacterium
adolescentis) 		PF00128
(Alpha-amylase)
PF09244
(DUF1964) 		4 TYR A 109
ARG A 150
ASP A 164
GLU A 200
 None
 1.24A 4ax8A-2gduA:
undetectable		 4ax8A-2gduA:
21.97
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2ihy ABC TRANSPORTER,
ATP-BINDING PROTEIN

(Staphylococcus
aureus) 		PF00005
(ABC_tran) 		4 ARG A 253
ASP A 174
GLU A 147
LEU A 182
 None
 1.24A 4ax8A-2ihyA:
undetectable		 4ax8A-2ihyA:
19.83
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2o8r POLYPHOSPHATE KINASE

(Porphyromonas
gingivalis) 		PF02503
(PP_kinase)
PF13089
(PP_kinase_N)
PF13090
(PP_kinase_C) 		4 TYR A  97
ASP A 102
GLU A 109
LEU A  40
 SO4  A 705 (-4.5A)
None
None
None
 1.27A 4ax8A-2o8rA:
undetectable		 4ax8A-2o8rA:
22.24
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2qyk CYCLIC AMP-SPECIFIC
PHOSPHODIESTERASE
HSPDE4A10

(Homo sapiens) 		PF00233
(PDEase_I) 		4 TYR A 435
ASP A 415
GLU A 455
LEU A 446
 None
 1.21A 4ax8A-2qykA:
undetectable		 4ax8A-2qykA:
22.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2w49 TROPONIN C, SKELETAL
MUSCLE

(Gallus gallus) 		PF13499
(EF-hand_7)
PF13833
(EF-hand_8) 		4 ARG 0  10
ASP 0  26
GLU 0  40
LEU 0  78
 None
None
CA  01003 (-2.3A)
None
 1.35A 4ax8A-2w490:
undetectable		 4ax8A-2w490:
14.29
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2zts PUTATIVE
UNCHARACTERIZED
PROTEIN PH0186

(Pyrococcus
horikoshii) 		PF06745
(ATPase) 		4 ARG A 150
ASP A  73
GLU A  89
LEU A  67
 None
 1.35A 4ax8A-2ztsA:
3.8		 4ax8A-2ztsA:
18.10
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3bdq STEROL CARRIER
PROTEIN 2-LIKE 2

(Aedes aegypti) 		PF02036
(SCP2) 		4 GLN A  48
ASP A  52
GLU A   8
LEU A  49
 None
 1.22A 4ax8A-3bdqA:
undetectable		 4ax8A-3bdqA:
11.25
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3c8z CYSTEINYL-TRNA
SYNTHETASE

(Mycolicibacterium
smegmatis) 		PF01406
(tRNA-synt_1e) 		4 GLN A 200
ARG A 178
ASP A 191
LEU A 201
 None
 1.21A 4ax8A-3c8zA:
undetectable		 4ax8A-3c8zA:
22.39
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3dls PAS
DOMAIN-CONTAINING
SERINE/THREONINE-PRO
TEIN KINASE

(Homo sapiens) 		PF00069
(Pkinase) 		4 GLN A1253
ARG A1110
ASP A1101
GLU A1264
 None
 1.42A 4ax8A-3dlsA:
3.4		 4ax8A-3dlsA:
20.58
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3e4b ALGK

(Pseudomonas
fluorescens) 		no annotation 4 GLN A 269
ASP A 275
GLU A 286
LEU A 254
 None
 1.14A 4ax8A-3e4bA:
undetectable		 4ax8A-3e4bA:
22.17
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3f8t PREDICTED ATPASE
INVOLVED IN
REPLICATION CONTROL,
CDC46/MCM FAMILY

(Methanopyrus
kandleri) 		PF00493
(MCM) 		4 ARG A 197
ASP A 475
GLU A 238
LEU A 467
 None
 1.22A 4ax8A-3f8tA:
undetectable		 4ax8A-3f8tA:
25.29
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3g4g CAMP-SPECIFIC
3',5'-CYCLIC
PHOSPHODIESTERASE 4D

(Homo sapiens) 		PF00233
(PDEase_I) 		4 TYR A 389
ASP A 369
GLU A 409
LEU A 400
 None
 1.21A 4ax8A-3g4gA:
undetectable		 4ax8A-3g4gA:
20.51
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3h2u RAVER-1

(Homo sapiens) 		PF00076
(RRM_1) 		4 ARG B 221
ASP B 209
GLU B 179
LEU B 217
 None
 1.41A 4ax8A-3h2uB:
undetectable		 4ax8A-3h2uB:
21.34
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3hea ARYLESTERASE

(Pseudomonas
fluorescens) 		PF00561
(Abhydrolase_1) 		4 TYR A 163
GLN A 176
GLU A 146
LEU A 180
 None
 1.21A 4ax8A-3heaA:
2.9		 4ax8A-3heaA:
18.71
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3hje 704AA LONG
HYPOTHETICAL
GLYCOSYLTRANSFERASE

(Sulfurisphaera
tokodaii) 		PF00128
(Alpha-amylase)
PF09196
(DUF1953) 		4 ARG A 588
ASP A 441
GLU A 514
LEU A 590
 None
GOL  A 802 ( 3.7A)
None
None
 1.27A 4ax8A-3hjeA:
undetectable		 4ax8A-3hjeA:
20.51
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3iup PUTATIVE
NADPH:QUINONE
OXIDOREDUCTASE

(Cupriavidus
pinatubonensis) 		no annotation 4 ARG A  68
ASP A  25
GLU A 103
LEU A   5
 None
EDO  A 381 (-3.3A)
None
None
 1.27A 4ax8A-3iupA:
5.5		 4ax8A-3iupA:
21.89
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3k9y 1,25-DIHYDROXYVITAMI
N D(3)
24-HYDROXYLASE,
MITOCHONDRIAL

(Rattus
norvegicus) 		PF00067
(p450) 		4 TYR A 220
ASP A 300
GLU A 171
LEU A 217
 None
 1.42A 4ax8A-3k9yA:
undetectable		 4ax8A-3k9yA:
22.24
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3kwl UNCHARACTERIZED
PROTEIN

(Helicobacter
pylori) 		no annotation 4 TYR A 276
ARG A 378
ASP A 273
LEU A 313
 None
 1.41A 4ax8A-3kwlA:
undetectable		 4ax8A-3kwlA:
23.24
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3lsc TRIAZINE HYDROLASE

(Paenarthrobacter
aurescens) 		PF01979
(Amidohydro_1) 		4 ARG A 419
ASP A 440
GLU A 109
LEU A 120
 None
 1.39A 4ax8A-3lscA:
undetectable		 4ax8A-3lscA:
22.49
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3mfq HIGH-AFFINITY ZINC
UPTAKE SYSTEM
PROTEIN ZNUA

(Streptococcus
suis) 		PF01297
(ZnuA) 		4 GLN A  49
ASP A 295
GLU A 182
LEU A 172
 None
 1.25A 4ax8A-3mfqA:
undetectable		 4ax8A-3mfqA:
21.14
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3oqv ALBC

(Streptomyces
noursei) 		PF16715
(CDPS) 		4 ARG A 117
ASP A 188
GLU A 133
LEU A 122
 None
 1.26A 4ax8A-3oqvA:
undetectable		 4ax8A-3oqvA:
19.18
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3pig BETA-FRUCTOFURANOSID
ASE

(Bifidobacterium
longum) 		PF00251
(Glyco_hydro_32N)
PF08244
(Glyco_hydro_32C) 		5 TYR A  40
ARG A  96
ASP A 465
GLU A 364
LEU A 517
 None
 1.21A 4ax8A-3pigA:
undetectable		 4ax8A-3pigA:
21.41
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3q41 GLUTAMATE [NMDA]
RECEPTOR SUBUNIT
ZETA-1

(Rattus
norvegicus) 		PF01094
(ANF_receptor) 		4 TYR A 351
GLN A 147
ARG A 124
GLU A 342
 None
 1.35A 4ax8A-3q41A:
3.6		 4ax8A-3q41A:
19.41
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3sl5 CAMP-SPECIFIC
3',5'-CYCLIC
PHOSPHODIESTERASE 4D

(Homo sapiens) 		PF00233
(PDEase_I) 		4 TYR A 223
ASP A 203
GLU A 243
LEU A 234
 TYR  A 223 ( 1.3A)
ASP  A 203 ( 0.6A)
GLU  A 243 ( 0.5A)
LEU  A 234 ( 0.6A)
 1.16A 4ax8A-3sl5A:
undetectable		 4ax8A-3sl5A:
21.36
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3u44 ATP-DEPENDENT
HELICASE/NUCLEASE
SUBUNIT A

(Bacillus
subtilis) 		PF00580
(UvrD-helicase)
PF12705
(PDDEXK_1)
PF13361
(UvrD_C) 		4 TYR A 187
GLN A 183
GLU A 863
LEU A 823
 None
 1.41A 4ax8A-3u44A:
undetectable		 4ax8A-3u44A:
19.72
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ayg GLUCANSUCRASE

(Lactobacillus
reuteri) 		PF01473
(CW_binding_1)
PF02324
(Glyco_hydro_70) 		4 TYR A1511
GLN A1509
GLU A 931
LEU A 940
 None
GOL  A2773 (-3.0A)
None
None
 1.27A 4ax8A-4aygA:
2.3		 4ax8A-4aygA:
20.81
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4azv WBDD

(Escherichia
coli) 		PF00069
(Pkinase)
PF13847
(Methyltransf_31) 		6 TYR A  16
GLN A  17
ARG A  36
ASP A  82
GLU A 111
LEU A 128
 SAM  A1474 (-3.5A)
SAM  A1474 (-3.5A)
SAM  A1474 ( 3.1A)
SAM  A1474 (-1.7A)
SAM  A1474 (-2.5A)
SAM  A1474 (-4.3A)
 0.09A 4ax8A-4azvA:
53.3		 4ax8A-4azvA:
99.82
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4azw WBDD

(Escherichia
coli) 		PF00069
(Pkinase)
PF13847
(Methyltransf_31) 		6 TYR A  16
GLN A  17
ARG A  36
ASP A  82
GLU A 111
LEU A 128
 SAM  A1451 (-3.6A)
SAM  A1451 (-3.9A)
SAM  A1451 (-3.2A)
SAM  A1451 (-2.7A)
SAM  A1451 (-3.1A)
SAM  A1451 (-4.1A)
 0.42A 4ax8A-4azwA:
51.5		 4ax8A-4azwA:
99.36
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4b67 L-ORNITHINE N5
MONOOXYGENASE

(Aspergillus
fumigatus) 		PF13434
(K_oxygenase) 		4 GLN A 102
ASP A 288
GLU A 294
LEU A 467
 NAP  A1493 (-4.0A)
None
None
FAD  A1492 (-3.8A)
 1.32A 4ax8A-4b67A:
2.4		 4ax8A-4b67A:
21.69
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4c25 L-FUCULOSE PHOSPHATE
ALDOLASE

(Streptococcus
pneumoniae) 		PF00596
(Aldolase_II) 		4 GLN A  36
ASP A  89
GLU A   7
LEU A  37
 None
 1.14A 4ax8A-4c25A:
undetectable		 4ax8A-4c25A:
16.23
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4fas HYDROXYLAMINE
OXIDOREDUCTASE

(Nitrosomonas
europaea) 		PF13447
(Multi-haem_cyto) 		4 TYR A  33
GLN A 236
ARG A 183
ASP A  59
 None
None
HEC  A 604 ( 4.3A)
None
 1.34A 4ax8A-4fasA:
undetectable		 4ax8A-4fasA:
19.47
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4g7w PUTATIVE
UNCHARACTERIZED
PROTEIN

(Vibrio cholerae) 		PF16710
(CTXphi_pIII-N1) 		4 GLN A  66
ASP A  35
GLU A  83
LEU A  28
 None
 1.01A 4ax8A-4g7wA:
undetectable		 4ax8A-4g7wA:
16.31
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4h1g MALTOSE BINDING
PROTEIN-CAKAR3 MOTOR
DOMAIN FUSION
PROTEIN

(Escherichia
coli;
Candida
albicans) 		PF00225
(Kinesin)
PF13416
(SBP_bac_8) 		4 ARG A 349
ASP A 432
GLU A 473
LEU A 426
 None
 1.40A 4ax8A-4h1gA:
undetectable		 4ax8A-4h1gA:
21.47
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4h3s GLUTAMINE-TRNA
LIGASE

(Saccharomyces
cerevisiae) 		PF00749
(tRNA-synt_1c)
PF03950
(tRNA-synt_1c_C)
PF04557
(tRNA_synt_1c_R2) 		4 TYR A 469
ASP A 474
GLU A 239
LEU A 446
 GOL  A 906 ( 4.9A)
None
None
None
 1.11A 4ax8A-4h3sA:
undetectable		 4ax8A-4h3sA:
20.51
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4hl0 GALECTIN

(Toxascaris
leonina) 		PF00337
(Gal-bind_lectin) 		4 TYR A 138
ASP A  94
GLU A 112
LEU A  25
 None
 1.40A 4ax8A-4hl0A:
undetectable		 4ax8A-4hl0A:
20.32
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4hvt POST-PROLINE
CLEAVING ENZYME

(Rickettsia
typhi) 		PF00326
(Peptidase_S9)
PF02897
(Peptidase_S9_N) 		4 GLN A  94
ASP A 679
GLU A  47
LEU A 688
 None
 1.00A 4ax8A-4hvtA:
undetectable		 4ax8A-4hvtA:
22.97
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4km3 METHIONINE
AMINOPEPTIDASE

(Streptococcus
pneumoniae) 		PF00557
(Peptidase_M24) 		4 TYR A  87
ASP A  77
GLU A 149
LEU A  95
 None
 1.27A 4ax8A-4km3A:
undetectable		 4ax8A-4km3A:
18.09
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4leu PENTATRICOPEPTIDE
REPEAT-CONTAINING
PROTEIN AT3G46870

(Arabidopsis
thaliana) 		PF13041
(PPR_2) 		4 ARG A 230
ASP A 248
GLU A 212
LEU A 220
 None
 1.40A 4ax8A-4leuA:
undetectable		 4ax8A-4leuA:
18.42
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4n0y IGH526 HEAVY CHAIN

(Homo sapiens) 		PF07654
(C1-set)
PF07686
(V-set) 		4 TYR H  27
GLN H   3
ASP H 101
LEU H   4
 None
 1.38A 4ax8A-4n0yH:
undetectable		 4ax8A-4n0yH:
17.54
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4nek ENOYL-COA
HYDRATASE/CARNITHINE
RACEMASE

(Magnetospirillum
magneticum) 		PF00378
(ECH_1) 		4 ARG A 218
ASP A 114
GLU A  43
LEU A 207
 None
 1.29A 4ax8A-4nekA:
undetectable		 4ax8A-4nekA:
18.38
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4pj3 INTRON-BINDING
PROTEIN AQUARIUS

(Homo sapiens) 		PF13086
(AAA_11)
PF13087
(AAA_12)
PF16399
(Aquarius_N) 		4 TYR A1112
ARG A 252
GLU A 158
LEU A 148
 None
 1.19A 4ax8A-4pj3A:
2.1		 4ax8A-4pj3A:
16.59
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4qhr ALANINE RACEMASE

(Acinetobacter
baumannii) 		PF00842
(Ala_racemase_C)
PF01168
(Ala_racemase_N) 		4 TYR A  15
ASP A   9
GLU A 321
LEU A 230
 None
 1.06A 4ax8A-4qhrA:
undetectable		 4ax8A-4qhrA:
22.05
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4r3u 2-HYDROXYISOBUTYRYL-
COA MUTASE LARGE
SUBUNIT

(Aquincola
tertiaricarbonis) 		PF01642
(MM_CoA_mutase) 		4 GLN A 526
ARG A 220
GLU A 184
LEU A 528
 None
 1.00A 4ax8A-4r3uA:
undetectable		 4ax8A-4r3uA:
22.62
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4rf7 ARGININE KINASE

(Anthopleura
japonica) 		PF00217
(ATP-gua_Ptrans)
PF02807
(ATP-gua_PtransN) 		4 ARG A 501
ASP A 408
GLU A 429
LEU A 496
 None
 1.26A 4ax8A-4rf7A:
undetectable		 4ax8A-4rf7A:
20.76
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4uxv SEPTATION RING
FORMATION REGULATOR
EZRA

(Bacillus
subtilis) 		PF06160
(EzrA) 		4 GLN A 406
ARG A 340
GLU A 417
LEU A 408
 None
 1.32A 4ax8A-4uxvA:
undetectable		 4ax8A-4uxvA:
23.70
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4wjl INACTIVE DIPEPTIDYL
PEPTIDASE 10

(Homo sapiens) 		PF00326
(Peptidase_S9)
PF00930
(DPPIV_N) 		4 GLN A 191
ASP A 247
GLU A 350
LEU A 251
 None
 1.15A 4ax8A-4wjlA:
undetectable		 4ax8A-4wjlA:
22.18
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4wzi CAMP-SPECIFIC
3',5'-CYCLIC
PHOSPHODIESTERASE 4B

(Homo sapiens) 		PF00233
(PDEase_I) 		4 TYR A 469
ASP A 449
GLU A 489
LEU A 480
 None
 1.23A 4ax8A-4wziA:
undetectable		 4ax8A-4wziA:
21.67
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4xgc ORIGIN RECOGNITION
COMPLEX SUBUNIT 5

(Drosophila
melanogaster) 		PF13191
(AAA_16)
PF14630
(ORC5_C) 		4 GLN E 182
ARG E  15
GLU E 164
LEU E 180
 None
 1.07A 4ax8A-4xgcE:
undetectable		 4ax8A-4xgcE:
23.20
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4yhg GH5

(Bacteroidetes
bacterium AC2a) 		PF00150
(Cellulase) 		4 GLN A 190
ASP A 129
GLU A 146
LEU A 194
 None
 1.24A 4ax8A-4yhgA:
undetectable		 4ax8A-4yhgA:
22.09
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4zwj CHIMERA PROTEIN OF
HUMAN RHODOPSIN,
MOUSE S-ARRESTIN,
AND T4 ENDOLYSIN

(Homo sapiens;
Mus musculus;
Escherichia
virus T4) 		PF00001
(7tm_1)
PF00339
(Arrestin_N)
PF00959
(Phage_lysozyme)
PF02752
(Arrestin_C)
PF10413
(Rhodopsin_N) 		4 ARG A 135
ASP A  83
GLU A 122
LEU A 131
 None
 1.36A 4ax8A-4zwjA:
undetectable		 4ax8A-4zwjA:
20.70
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5a29 EXOPOLYGALACTURONATE
LYASE

(Vibrio
vulnificus) 		PF06917
(Pectate_lyase_2) 		4 TYR A 157
ASP A 514
GLU A 517
LEU A  90
 EDO  A1574 ( 4.9A)
EDO  A1572 ( 4.7A)
None
None
 1.01A 4ax8A-5a29A:
undetectable		 4ax8A-5a29A:
22.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5cwa ANTHRANILATE
SYNTHASE COMPONENT 1

(Mycobacterium
tuberculosis) 		PF00425
(Chorismate_bind)
PF04715
(Anth_synt_I_N) 		4 ARG A 464
ASP A 156
GLU A 146
LEU A 152
 None
None
None
GOL  A 605 (-4.7A)
 1.41A 4ax8A-5cwaA:
2.5		 4ax8A-5cwaA:
21.43
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5fu7 CCR4-NOT
TRANSCRIPTION
COMPLEX SUBUNIT 1
CCR4-NOT
TRANSCRIPTION
COMPLEX SUBUNIT 2

(Homo sapiens;
Homo sapiens) 		PF04054
(Not1)
PF04153
(NOT2_3_5) 		4 ARG A2197
ASP B 353
GLU A2298
LEU A2258
 None
 1.24A 4ax8A-5fu7A:
undetectable		 4ax8A-5fu7A:
23.52
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5gai PORTAL PROTEIN

(Salmonella
virus P22) 		PF16510
(P22_portal) 		4 TYR A 447
ARG A 458
ASP A  77
LEU A  94
 None
 1.17A 4ax8A-5gaiA:
undetectable		 4ax8A-5gaiA:
22.07
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5h1a ICLR TRANSCRIPTION
FACTOR HOMOLOG

(Microbacterium
sp.) 		PF01614
(IclR)
PF09339
(HTH_IclR) 		4 GLN A  86
ASP A 244
GLU A 236
LEU A  89
 None
 1.20A 4ax8A-5h1aA:
undetectable		 4ax8A-5h1aA:
19.82
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5hb3 NUCLEOPORIN NIC96

(Chaetomium
thermophilum) 		PF04097
(Nic96) 		4 GLN A 652
ARG A 533
ASP A 542
LEU A 539
 None
 1.35A 4ax8A-5hb3A:
undetectable		 4ax8A-5hb3A:
23.70
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5hb4 NUP192,NUCLEOPORIN
NUP192

(Chaetomium
thermophilum) 		PF11894
(Nup192) 		4 ARG B 875
ASP B 390
GLU B 717
LEU B 787
 None
 1.23A 4ax8A-5hb4B:
undetectable		 4ax8A-5hb4B:
17.18
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5hr4 MMEI

(Methylophilus
methylotrophus) 		no annotation 4 ARG C 168
ASP C 201
GLU C 212
LEU C 282
 None
CA  C1001 (-2.1A)
None
None
 1.37A 4ax8A-5hr4C:
9.4		 4ax8A-5hr4C:
21.30
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5hwq HYDROXYMETHYLGLUTARY
L-COA SYNTHASE

(Myxococcus
xanthus) 		PF01154
(HMG_CoA_synt_N)
PF08540
(HMG_CoA_synt_C) 		4 GLN A 324
ARG A 306
ASP A 365
LEU A 370
 SO4  A 506 (-3.6A)
None
SO4  A 506 ( 4.9A)
None
 1.16A 4ax8A-5hwqA:
2.0		 4ax8A-5hwqA:
22.77
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ik2 ATP SYNTHASE SUBUNIT
ALPHA

(Caldalkalibacillus
thermarum) 		PF00006
(ATP-synt_ab)
PF00306
(ATP-synt_ab_C)
PF02874
(ATP-synt_ab_N) 		4 ARG A 465
ASP A 423
GLU A 418
LEU A 461
 None
 1.36A 4ax8A-5ik2A:
undetectable		 4ax8A-5ik2A:
23.73
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ip9 DNA-DIRECTED RNA
POLYMERASES I, II,
AND III SUBUNIT
RPABC3

(Saccharomyces
cerevisiae) 		PF03870
(RNA_pol_Rpb8) 		4 TYR H 115
ASP H  41
GLU H  14
LEU H 125
 None
 1.20A 4ax8A-5ip9H:
2.1		 4ax8A-5ip9H:
13.81
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5iv9 LPS-ASSEMBLY PROTEIN
LPTD
LPS-ASSEMBLY
LIPOPROTEIN LPTE

(Klebsiella
pneumoniae;
Klebsiella
pneumoniae) 		PF03968
(OstA)
PF04453
(OstA_C)
PF04390
(LptE) 		4 GLN A 369
ARG A 405
ASP B 141
LEU A 522
 None
 1.08A 4ax8A-5iv9A:
undetectable		 4ax8A-5iv9A:
21.03
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5k5m RNA DEPENDENT RNA
POLYMERASE

(Dengue virus) 		PF00972
(Flavi_NS5) 		4 GLN A 760
ASP A 808
GLU A 831
LEU A 764
 None
 1.27A 4ax8A-5k5mA:
undetectable		 4ax8A-5k5mA:
21.90
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ko9 EMBRYONIC STEM
CELL-SPECIFIC
5-HYDROXYMETHYLCYTOS
INE-BINDING PROTEIN

(Homo sapiens) 		PF02586
(SRAP) 		4 GLN A  27
ASP A  22
GLU A  60
LEU A  29
 None
 1.11A 4ax8A-5ko9A:
undetectable		 4ax8A-5ko9A:
18.20
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5lcw MITOTIC CHECKPOINT
SERINE/THREONINE-PRO
TEIN KINASE BUB1
BETA,MITOTIC
CHECKPOINT
SERINE/THREONINE-PRO
TEIN KINASE BUB1
BETA

(Homo sapiens) 		PF08311
(Mad3_BUB1_I) 		4 GLN S  91
ARG S  36
GLU S 161
LEU S  32
 None
 1.37A 4ax8A-5lcwS:
undetectable		 4ax8A-5lcwS:
22.90
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5mdn DNA POLYMERASE

(Pyrobaculum
calidifontis) 		PF00136
(DNA_pol_B)
PF03104
(DNA_pol_B_exo1) 		4 ARG A 305
ASP A 671
GLU A 318
LEU A 310
 None
 1.27A 4ax8A-5mdnA:
undetectable		 4ax8A-5mdnA:
22.28
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5n9j MEDIATOR OF RNA
POLYMERASE II
TRANSCRIPTION
SUBUNIT 14
MEDIATOR OF RNA
POLYMERASE II
TRANSCRIPTION
SUBUNIT 17

(Schizosaccharomyces
pombe;
Schizosaccharomyces
pombe) 		PF08638
(Med14)
PF10156
(Med17) 		4 GLN W 302
ASP W 309
GLU A 288
LEU W 301
 None
 1.36A 4ax8A-5n9jW:
undetectable		 4ax8A-5n9jW:
20.87
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5nju GENOME POLYPROTEIN

(Zika virus) 		no annotation 4 GLN A 238
ASP A 245
GLU A  23
LEU A 240
 None
 1.15A 4ax8A-5njuA:
8.6		 4ax8A-5njuA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5nug CYTOPLASMIC DYNEIN 1
HEAVY CHAIN 1

(Homo sapiens) 		PF03028
(Dynein_heavy)
PF07728
(AAA_5)
PF08393
(DHC_N2)
PF12774
(AAA_6)
PF12775
(AAA_7)
PF12777
(MT)
PF12780
(AAA_8)
PF12781
(AAA_9) 		4 ARG A3007
ASP A2636
GLU A3048
LEU A3020
 None
 1.32A 4ax8A-5nugA:
undetectable		 4ax8A-5nugA:
8.27
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5oa3 EUKARYOTIC
TRANSLATION
INITIATION FACTOR 2D

(Homo sapiens) 		no annotation 4 GLN 0 545
ARG 0 498
ASP 0 492
GLU 0 575
 None
 1.38A 4ax8A-5oa30:
2.1		 4ax8A-5oa30:
21.88
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ohj CAMP-SPECIFIC
3',5'-CYCLIC
PHOSPHODIESTERASE 4B

(Homo sapiens) 		no annotation 4 TYR A 469
ASP A 449
GLU A 489
LEU A 480
 None
 1.35A 4ax8A-5ohjA:
undetectable		 4ax8A-5ohjA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5sy4 CHAPERONE YAJL

(Escherichia
coli) 		PF01965
(DJ-1_PfpI) 		4 GLN A 138
ASP A 117
GLU A  90
LEU A 152
 None
 1.30A 4ax8A-5sy4A:
3.8		 4ax8A-5sy4A:
17.49
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5u89 AMINO ACID
ADENYLATION DOMAIN
PROTEIN

(Geobacillus sp.
Y4.1MC1) 		PF00501
(AMP-binding)
PF00550
(PP-binding)
PF00668
(Condensation)
PF13193
(AMP-binding_C) 		4 GLN A1227
ARG A1061
GLU A1105
LEU A1056
 None
 1.13A 4ax8A-5u89A:
3.6		 4ax8A-5u89A:
20.13
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5voc ENVELOPE
GLYCOPROTEIN H

(Human
betaherpesvirus
5) 		PF02489
(Herpes_glycop_H)
PF17488
(Herpes_glycoH_C) 		4 ARG A 421
ASP A 517
GLU A 499
LEU A 469
 None
 1.07A 4ax8A-5vocA:
undetectable		 4ax8A-5vocA:
21.39
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5wh6 CAMP-SPECIFIC
3',5'-CYCLIC
PHOSPHODIESTERASE 4D

(Homo sapiens) 		no annotation 4 TYR A 223
ASP A 203
GLU A 243
LEU A 234
 None
 1.22A 4ax8A-5wh6A:
undetectable		 4ax8A-5wh6A:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5z06 BDI_3064 PROTEIN

(Parabacteroides
distasonis) 		no annotation 4 TYR A 315
GLN A 685
GLU A  29
LEU A 679
 None
 1.30A 4ax8A-5z06A:
undetectable		 4ax8A-5z06A:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6bfi VIN1

(Oscarella
pearsei) 		no annotation 4 GLN A 358
ARG A 365
ASP A 280
GLU A 680
 None
 1.23A 4ax8A-6bfiA:
undetectable		 4ax8A-6bfiA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6bzh PROBABLE
ATP-DEPENDENT RNA
HELICASE DDX58

(Mus musculus) 		no annotation 4 TYR A  15
ARG A 104
ASP A  93
LEU A 100
 None
 1.21A 4ax8A-6bzhA:
undetectable		 4ax8A-6bzhA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6f5d ATP SYNTHASE GAMMA
SUBUNIT
ATP SYNTHASE DELTA
SUBUNIT
ATP SYNTHASE EPSILON
SUBUNIT

(Trypanosoma
brucei;
Trypanosoma
brucei;
Trypanosoma
brucei) 		no annotation
no annotation
no annotation 		4 TYR I  14
ASP G 215
GLU G 209
LEU H  75
 None
 1.29A 4ax8A-6f5dI:
undetectable		 4ax8A-6f5dI:
undetectable