SIMILAR PATTERNS OF AMINO ACIDS FOR 4AT0_A_ACTA1490_0

List of similar pattern of amino acids derived from ASSAM search

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click link on the last column to view superposed patterns of amino acids in NGL viewer)
(Note that only 3-12 residue patterns can be used for ASSAM searches)
Filter list by:
Hit Macromolecule/
Organism		 Pfam Res. Interface HETATM RMSD Dali Z-score Seq. Identity (%) View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
12as ASPARAGINE
SYNTHETASE

(Escherichia
coli) 		PF03590
(AsnA) 		3 GLU A  31
TYR A  93
SER A  20
 None
 0.99A 4at0A-12asA:
undetectable		 4at0A-12asA:
22.44
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ak0 P1 NUCLEASE

(Penicillium
citrinum) 		PF02265
(S1-P1_nuclease) 		3 GLU A 170
TYR A  11
SER A  35
 None
 0.77A 4at0A-1ak0A:
0.0		 4at0A-1ak0A:
21.68
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1bq0 DNAJ

(Escherichia
coli) 		PF00226
(DnaJ) 		3 GLU A   7
TYR A   6
SER A  12
 None
 0.58A 4at0A-1bq0A:
undetectable		 4at0A-1bq0A:
12.61
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1dle COMPLEMENT FACTOR B

(Homo sapiens) 		PF00089
(Trypsin) 		3 GLU A  49
TYR A 114
SER A   1
 None
 0.89A 4at0A-1dleA:
0.0		 4at0A-1dleA:
19.96
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1drt CLAVAMINATE SYNTHASE
1

(Streptomyces
clavuligerus) 		PF02668
(TauD) 		3 GLU A 135
TYR A 124
SER A  81
 None
 0.96A 4at0A-1drtA:
0.0		 4at0A-1drtA:
21.94
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1e3j NADP(H)-DEPENDENT
KETOSE REDUCTASE

(Bemisia
argentifolii) 		PF00107
(ADH_zinc_N)
PF08240
(ADH_N) 		3 GLU A 146
TYR A  37
SER A 348
 None
 0.72A 4at0A-1e3jA:
2.7		 4at0A-1e3jA:
23.76
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1gll GLYCEROL KINASE

(Escherichia
coli) 		no annotation 3 GLU Y 222
TYR Y 224
SER Y 240
 None
 0.92A 4at0A-1gllY:
0.0		 4at0A-1gllY:
21.82
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ha5 STREPTOCOCCAL
PYOGENIC EXOTOXIN A1

(Streptococcus
pyogenes) 		PF01123
(Stap_Strp_toxin)
PF02876
(Stap_Strp_tox_C) 		3 GLU A1061
TYR A1100
SER A1195
 None
 1.00A 4at0A-1ha5A:
undetectable		 4at0A-1ha5A:
16.67
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1lw3 MYOTUBULARIN-RELATED
PROTEIN 2

(Homo sapiens) 		PF02893
(GRAM)
PF06602
(Myotub-related) 		3 GLU A 300
TYR A 343
SER A 339
 None
 0.96A 4at0A-1lw3A:
undetectable		 4at0A-1lw3A:
22.42
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ms8 TRANS-SIALIDASE

(Trypanosoma
cruzi) 		PF13385
(Laminin_G_3)
PF13859
(BNR_3) 		3 GLU A  78
TYR A  69
SER A 150
 None
 0.68A 4at0A-1ms8A:
0.0		 4at0A-1ms8A:
23.96
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1mwo ALPHA AMYLASE

(Pyrococcus
woesei) 		PF00128
(Alpha-amylase)
PF09154
(DUF1939) 		3 GLU A  72
TYR A  73
SER A 136
 None
 0.73A 4at0A-1mwoA:
undetectable		 4at0A-1mwoA:
21.61
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1no7 MAJOR CAPSID PROTEIN

(Human
alphaherpesvirus
1) 		PF03122
(Herpes_MCP) 		3 GLU A 638
TYR A 673
SER A 669
 None
 1.02A 4at0A-1no7A:
undetectable		 4at0A-1no7A:
23.79
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1no7 MAJOR CAPSID PROTEIN

(Human
alphaherpesvirus
1) 		PF03122
(Herpes_MCP) 		3 GLU A 638
TYR A 673
SER A 672
 None
 0.97A 4at0A-1no7A:
undetectable		 4at0A-1no7A:
23.79
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1poi GLUTACONATE COENZYME
A-TRANSFERASE

(Acidaminococcus
fermentans) 		PF01144
(CoA_trans) 		3 GLU B 236
TYR B 212
SER B 217
 None
 0.90A 4at0A-1poiB:
undetectable		 4at0A-1poiB:
19.10
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1pto PERTUSSIS TOXIN

(Bordetella
pertussis) 		PF02918
(Pertussis_S2S3)
PF03440
(APT) 		3 GLU C  84
TYR C  55
SER C  53
 None
 0.98A 4at0A-1ptoC:
undetectable		 4at0A-1ptoC:
17.59
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1qfx PROTEIN (PH 2.5 ACID
PHOSPHATASE)

(Aspergillus
niger) 		PF00328
(His_Phos_2) 		3 GLU A 166
TYR A 173
SER A 174
 None
 1.01A 4at0A-1qfxA:
undetectable		 4at0A-1qfxA:
22.18
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1qwr MANNOSE-6-PHOSPHATE
ISOMERASE

(Bacillus
subtilis) 		PF01238
(PMI_typeI) 		3 GLU A 282
TYR A 281
SER A   4
 None
 0.94A 4at0A-1qwrA:
undetectable		 4at0A-1qwrA:
21.51
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1um7 SYNAPSE-ASSOCIATED
PROTEIN 102

(Homo sapiens) 		PF00595
(PDZ) 		3 GLU A 106
TYR A 102
SER A  44
 None
 0.93A 4at0A-1um7A:
undetectable		 4at0A-1um7A:
14.02
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1un1 XYLOGLUCAN
ENDOTRANSGLYCOSYLASE

(Populus tremula) 		PF00722
(Glyco_hydro_16)
PF06955
(XET_C) 		3 GLU A 208
TYR A  51
SER A  50
 None
 0.96A 4at0A-1un1A:
undetectable		 4at0A-1un1A:
20.16
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1zsq MYOTUBULARIN-RELATED
PROTEIN 2

(Homo sapiens) 		PF02893
(GRAM)
PF06602
(Myotub-related) 		3 GLU A 300
TYR A 343
SER A 339
 None
 0.98A 4at0A-1zsqA:
undetectable		 4at0A-1zsqA:
23.59
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2e2n HEXOKINASE

(Sulfurisphaera
tokodaii) 		PF01869
(BcrAD_BadFG) 		3 GLU A 225
TYR A 262
SER A 229
 None
 0.85A 4at0A-2e2nA:
undetectable		 4at0A-2e2nA:
22.40
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2fa0 HMG-COA SYNTHASE

(Brassica juncea) 		PF01154
(HMG_CoA_synt_N)
PF08540
(HMG_CoA_synt_C) 		3 GLU A 200
TYR A 414
SER A 199
 None
 0.97A 4at0A-2fa0A:
undetectable		 4at0A-2fa0A:
23.73
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2gaf POLY(A) POLYMERASE
CATALYTIC SUBUNIT

(Vaccinia virus) 		PF03296
(Pox_polyA_pol)
PF12629
(Pox_polyA_pol_C)
PF12630
(Pox_polyA_pol_N) 		3 GLU D 363
TYR D 399
SER D 401
 None
 0.82A 4at0A-2gafD:
undetectable		 4at0A-2gafD:
19.32
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2hlp MALATE DEHYDROGENASE

(Haloarcula
marismortui) 		PF00056
(Ldh_1_N)
PF02866
(Ldh_1_C) 		3 GLU A 151
TYR A 326
SER A 330
 None
 1.01A 4at0A-2hlpA:
2.9		 4at0A-2hlpA:
21.61
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2hqy CONSERVED
HYPOTHETICAL PROTEIN

(Bacteroides
thetaiotaomicron) 		PF09924
(DUF2156) 		3 GLU A 116
TYR A 291
SER A  98
 None
 0.90A 4at0A-2hqyA:
undetectable		 4at0A-2hqyA:
18.79
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2l3b CONSERVED PROTEIN
FOUND IN CONJUGATE
TRANSPOSON

(Bacteroides
thetaiotaomicron) 		PF12988
(DUF3872) 		3 GLU A  31
TYR A  84
SER A  63
 None
 0.84A 4at0A-2l3bA:
undetectable		 4at0A-2l3bA:
12.16
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2lfc FUMARATE REDUCTASE,
FLAVOPROTEIN SUBUNIT

(Lactobacillus
plantarum) 		PF00890
(FAD_binding_2) 		3 GLU A 150
TYR A  55
SER A  27
 None
 0.99A 4at0A-2lfcA:
10.4		 4at0A-2lfcA:
14.31
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2qts ACID-SENSING ION
CHANNEL

(Gallus gallus) 		PF00858
(ASC) 		3 GLU A 278
TYR A 371
SER A 252
 None
None
NAG  A   1 ( 4.0A)
 0.91A 4at0A-2qtsA:
undetectable		 4at0A-2qtsA:
23.70
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2qwv UPF0217 PROTEIN
VC_A1059

(Vibrio cholerae) 		PF04013
(Methyltrn_RNA_2) 		3 GLU A 176
TYR A 134
SER A 132
 None
 0.94A 4at0A-2qwvA:
undetectable		 4at0A-2qwvA:
17.86
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2r4f 3-HYDROXY-3-METHYLGL
UTARYL-COENZYME A
REDUCTASE

(Homo sapiens) 		PF00368
(HMG-CoA_red) 		3 GLU A 782
TYR A 792
SER A 794
 None
 0.95A 4at0A-2r4fA:
undetectable		 4at0A-2r4fA:
21.29
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2yq8 PROLYL 4-HYDROXYLASE
SUBUNIT ALPHA-1

(Homo sapiens) 		PF08336
(P4Ha_N) 		3 GLU A  32
TYR A  28
SER A  90
 None
 0.95A 4at0A-2yq8A:
undetectable		 4at0A-2yq8A:
17.88
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2yqp PROBABLE
ATP-DEPENDENT RNA
HELICASE DDX59

(Homo sapiens) 		PF04438
(zf-HIT) 		3 GLU A  30
TYR A  31
SER A  42
 None
 0.77A 4at0A-2yqpA:
undetectable		 4at0A-2yqpA:
9.07
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3bga BETA-GALACTOSIDASE

(Bacteroides
thetaiotaomicron) 		PF00703
(Glyco_hydro_2)
PF02836
(Glyco_hydro_2_C)
PF02837
(Glyco_hydro_2_N)
PF02929
(Bgal_small_N)
PF16353
(DUF4981) 		3 GLU A  63
TYR A  68
SER A  70
 None
 0.75A 4at0A-3bgaA:
undetectable		 4at0A-3bgaA:
18.78
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3bwk CYSTEINE PROTEASE
FALCIPAIN-3

(Plasmodium
falciparum) 		PF00112
(Peptidase_C1) 		3 GLU A 130
TYR A 132
SER A 109
 None
 0.88A 4at0A-3bwkA:
undetectable		 4at0A-3bwkA:
19.06
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ce9 GLYCEROL
DEHYDROGENASE

(Clostridium
acetobutylicum) 		PF13685
(Fe-ADH_2) 		3 GLU A  67
TYR A  39
SER A  37
 PEG  A 404 (-4.0A)
None
None
 0.98A 4at0A-3ce9A:
undetectable		 4at0A-3ce9A:
21.07
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ctt MALTASE-GLUCOAMYLASE

(Homo sapiens) 		PF00088
(Trefoil)
PF01055
(Glyco_hydro_31)
PF16863
(NtCtMGAM_N) 		3 GLU A 823
TYR A 844
SER A 846
 None
 0.75A 4at0A-3cttA:
undetectable		 4at0A-3cttA:
20.64
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3dec BETA-GALACTOSIDASE

(Bacteroides
thetaiotaomicron) 		PF00703
(Glyco_hydro_2)
PF02836
(Glyco_hydro_2_C)
PF02837
(Glyco_hydro_2_N)
PF02929
(Bgal_small_N)
PF16353
(DUF4981) 		3 GLU A  39
TYR A  44
SER A  46
 None
 0.82A 4at0A-3decA:
undetectable		 4at0A-3decA:
19.28
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3fgb UNCHARACTERIZED
PROTEIN Q89ZH8_BACTN

(Bacteroides
thetaiotaomicron) 		PF10282
(Lactonase) 		3 GLU A 261
TYR A 246
SER A 245
 None
 0.99A 4at0A-3fgbA:
undetectable		 4at0A-3fgbA:
20.87
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3fw8 RETICULINE OXIDASE

(Eschscholzia
californica) 		PF01565
(FAD_binding_4)
PF08031
(BBE) 		3 GLU A 154
TYR A 150
SER A 342
 None
 0.70A 4at0A-3fw8A:
undetectable		 4at0A-3fw8A:
20.04
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3gqj CELL INHIBITING
FACTOR (CIF)

(Photorhabdus
laumondii) 		PF16374
(CIF) 		3 GLU A 280
TYR A 170
SER A 165
 None
 0.79A 4at0A-3gqjA:
undetectable		 4at0A-3gqjA:
18.40
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3gqk PRENECK APPENDAGE
PROTEIN

(Bacillus virus
phi29) 		PF11962
(Peptidase_G2) 		3 GLU A 741
TYR A 696
SER A 790
 None
 0.95A 4at0A-3gqkA:
undetectable		 4at0A-3gqkA:
16.47
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3h0g DNA-DIRECTED RNA
POLYMERASE II
SUBUNIT RPB1
DNA-DIRECTED RNA
POLYMERASES I, II,
AND III SUBUNIT
RPABC1

(Schizosaccharomyces
pombe;
Schizosaccharomyces
pombe) 		PF00623
(RNA_pol_Rpb1_2)
PF04983
(RNA_pol_Rpb1_3)
PF04990
(RNA_pol_Rpb1_7)
PF04992
(RNA_pol_Rpb1_6)
PF04997
(RNA_pol_Rpb1_1)
PF04998
(RNA_pol_Rpb1_5)
PF05000
(RNA_pol_Rpb1_4)
PF01191
(RNA_pol_Rpb5_C)
PF03871
(RNA_pol_Rpb5_N) 		3 GLU A 876
TYR E 203
SER E 205
 None
 0.81A 4at0A-3h0gA:
undetectable		 4at0A-3h0gA:
15.48
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3h4x PHOSPHATIDYLINOSITOL
-SPECIFIC
PHOSPHOLIPASE C1

(Streptomyces
antibioticus) 		PF16670
(PI-PLC-C1) 		3 GLU A  41
TYR A  40
SER A  75
 None
 0.56A 4at0A-3h4xA:
undetectable		 4at0A-3h4xA:
25.38
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3hbz PUTATIVE GLYCOSIDE
HYDROLASE

(Bacteroides
thetaiotaomicron) 		PF13201
(PCMD) 		3 GLU A 296
TYR A 238
SER A 346
 None
 1.00A 4at0A-3hbzA:
undetectable		 4at0A-3hbzA:
23.06
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3hcw MALTOSE OPERON
TRANSCRIPTIONAL
REPRESSOR

(Staphylococcus
aureus) 		PF13377
(Peripla_BP_3) 		3 GLU A 206
TYR A 216
SER A 210
 None
 0.99A 4at0A-3hcwA:
undetectable		 4at0A-3hcwA:
17.45
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3hh1 TETRAPYRROLE
METHYLASE FAMILY
PROTEIN

(Chlorobaculum
tepidum) 		PF00590
(TP_methylase) 		3 GLU A  41
TYR A  63
SER A  65
 None
 0.96A 4at0A-3hh1A:
undetectable		 4at0A-3hh1A:
13.73
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3i1a SPECTINOMYCIN
PHOSPHOTRANSFERASE

(Legionella
pneumophila) 		PF01636
(APH) 		3 GLU A 283
TYR A 279
SER A 196
 None
 0.81A 4at0A-3i1aA:
undetectable		 4at0A-3i1aA:
20.50
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3iec SERINE/THREONINE-PRO
TEIN KINASE MARK2

(Homo sapiens) 		PF00069
(Pkinase)
PF00627
(UBA) 		3 GLU A  78
TYR A 131
SER A 133
 None
 0.85A 4at0A-3iecA:
undetectable		 4at0A-3iecA:
20.32
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3jux PROTEIN TRANSLOCASE
SUBUNIT SECA

(Thermotoga
maritima) 		PF00271
(Helicase_C)
PF01043
(SecA_PP_bind)
PF07516
(SecA_SW)
PF07517
(SecA_DEAD) 		3 GLU A 206
TYR A 157
SER A 156
 None
 1.01A 4at0A-3juxA:
undetectable		 4at0A-3juxA:
21.38
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3py9 PROTEIN KINASE

(Staphylococcus
aureus) 		PF03793
(PASTA) 		3 GLU A 103
TYR A 136
SER A 119
 None
 0.96A 4at0A-3py9A:
undetectable		 4at0A-3py9A:
19.88
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3qgv ALPHA AMYLASE

(Pyrococcus
woesei) 		PF00128
(Alpha-amylase)
PF09154
(DUF1939) 		3 GLU A  72
TYR A  73
SER A 136
 SUC  A 701 (-3.1A)
None
None
 0.99A 4at0A-3qgvA:
undetectable		 4at0A-3qgvA:
21.98
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3qha PUTATIVE
OXIDOREDUCTASE

(Mycobacterium
avium) 		PF03446
(NAD_binding_2)
PF14833
(NAD_binding_11) 		3 GLU A 252
TYR A 276
SER A 256
 None
 1.01A 4at0A-3qhaA:
1.9		 4at0A-3qhaA:
21.83
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ram HMRA PROTEIN

(Staphylococcus
aureus) 		PF01546
(Peptidase_M20)
PF07687
(M20_dimer) 		3 GLU A  35
TYR A  83
SER A  39
 None
 0.98A 4at0A-3ramA:
undetectable		 4at0A-3ramA:
23.52
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3syb GLYCINE-GLUTAMATE
DIPEPTIDE PORIN OPDP

(Pseudomonas
aeruginosa) 		PF03573
(OprD) 		3 GLU A 216
TYR A 326
SER A 331
 None
 0.87A 4at0A-3sybA:
undetectable		 4at0A-3sybA:
23.79
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3v0a NTNH

(Clostridium
botulinum) 		PF01742
(Peptidase_M27)
PF07953
(Toxin_R_bind_N)
PF08470
(NTNH_C) 		3 GLU B 342
TYR B 338
SER B 452
 None
 0.51A 4at0A-3v0aB:
undetectable		 4at0A-3v0aB:
16.77
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3vsv XYLOSIDASE

(Thermoanaerobacterium
saccharolyticum) 		PF13229
(Beta_helix) 		3 GLU A 588
TYR A 526
SER A 500
 None
 0.78A 4at0A-3vsvA:
undetectable		 4at0A-3vsvA:
21.29
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3wmt PROBABLE FERULOYL
ESTERASE B-1

(Aspergillus
oryzae) 		PF07519
(Tannase) 		3 GLU A 257
TYR A 345
SER A 346
 None
 0.98A 4at0A-3wmtA:
undetectable		 4at0A-3wmtA:
22.67
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3zpx LIPASE

(Ustilago maydis) 		PF03583
(LIP) 		3 GLU A 370
TYR A 183
SER A 184
 None
 0.80A 4at0A-3zpxA:
1.3		 4at0A-3zpxA:
21.44
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4at0 3-KETOSTEROID-DELTA4
-5ALPHA-DEHYDROGENAS
E

(Rhodococcus
jostii) 		PF00890
(FAD_binding_2) 		3 GLU A 290
TYR A 466
SER A 468
 ACT  A1490 ( 4.4A)
ACT  A1490 ( 4.4A)
ACT  A1490 (-2.6A)
 0.00A 4at0A-4at0A:
73.7		 4at0A-4at0A:
100.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4cvu BETA-MANNOSIDASE

(Trichoderma
harzianum) 		PF00703
(Glyco_hydro_2) 		3 GLU A 686
TYR A 586
SER A 580
 None
 0.99A 4at0A-4cvuA:
undetectable		 4at0A-4cvuA:
18.79
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ged ASCORBATE PEROXIDASE

(Leishmania
major) 		PF00141
(peroxidase) 		3 GLU A  49
TYR A 134
SER A  53
 None
 0.90A 4at0A-4gedA:
undetectable		 4at0A-4gedA:
20.24
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4had PROBABLE
OXIDOREDUCTASE
PROTEIN

(Rhizobium etli) 		PF01408
(GFO_IDH_MocA) 		3 GLU A 200
TYR A 210
SER A 211
 None
 0.90A 4at0A-4hadA:
undetectable		 4at0A-4hadA:
22.50
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4had PROBABLE
OXIDOREDUCTASE
PROTEIN

(Rhizobium etli) 		PF01408
(GFO_IDH_MocA) 		3 GLU A 200
TYR A 210
SER A 212
 None
 0.88A 4at0A-4hadA:
undetectable		 4at0A-4hadA:
22.50
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ij3 SULFHYDRYL OXIDASE 1

(Homo sapiens) 		PF00085
(Thioredoxin) 		3 GLU A 186
TYR A 187
SER A 267
 None
 0.82A 4at0A-4ij3A:
undetectable		 4at0A-4ij3A:
17.86
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4nx1 C4-DICARBOXYLATE
TRANSPORT SYSTEM
SUBSTRATE-BINDING
PROTEIN

(Sulfitobacter
sp. NAS-14.1) 		PF03480
(DctP) 		3 GLU A  75
TYR A  78
SER A  35
 X1X  A 401 (-2.8A)
None
None
 0.90A 4at0A-4nx1A:
undetectable		 4at0A-4nx1A:
24.25
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4nzp ARGININOSUCCINATE
SYNTHASE

(Campylobacter
jejuni) 		PF00764
(Arginosuc_synth) 		3 GLU A 133
TYR A 136
SER A 119
 None
 1.00A 4at0A-4nzpA:
undetectable		 4at0A-4nzpA:
23.46
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4od1 CAP256-VRC26.03
HEAVY CHAIN

(Homo sapiens) 		PF07654
(C1-set)
PF07686
(V-set) 		3 GLU H  98
TYR H  32
SER H  28
 None
 0.99A 4at0A-4od1H:
undetectable		 4at0A-4od1H:
17.51
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4pw8 TRYPTOPHAN
2,3-DIOXYGENASE

(Homo sapiens) 		PF03301
(Trp_dioxygenase) 		3 GLU A 145
TYR A 146
SER A  59
 None
 0.98A 4at0A-4pw8A:
undetectable		 4at0A-4pw8A:
20.30
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4s3k SPORE GERMINATION
PROTEIN YAAH

(Bacillus
megaterium) 		PF00704
(Glyco_hydro_18)
PF01476
(LysM) 		3 GLU A 311
TYR A 307
SER A 255
 None
 0.94A 4at0A-4s3kA:
undetectable		 4at0A-4s3kA:
20.44
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4upe NICKEL-DEPENDENT
HYDROGENASE LARGE
SUBUNIT

(Desulfovibrio
fructosivorans) 		PF00374
(NiFeSe_Hases) 		3 GLU Q 382
TYR Q 289
SER Q 287
 None
 1.00A 4at0A-4upeQ:
undetectable		 4at0A-4upeQ:
21.70
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4v17 CARBOHYDRATE BINDING
MODULE

(Ruminococcus
flavefaciens) 		no annotation 3 GLU A 521
TYR A 495
SER A 489
 None
 0.99A 4at0A-4v17A:
undetectable		 4at0A-4v17A:
14.90
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4v1r ALPHA-1,6-MANNANASE

(Bacteroides
thetaiotaomicron) 		PF03663
(Glyco_hydro_76) 		3 GLU A 298
TYR A 302
SER A 304
 None
 0.98A 4at0A-4v1rA:
undetectable		 4at0A-4v1rA:
19.89
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4wj3 ASPARTATE--TRNA(ASP/
ASN) LIGASE

(Pseudomonas
aeruginosa) 		PF00152
(tRNA-synt_2)
PF01336
(tRNA_anti-codon)
PF02938
(GAD) 		3 GLU M 244
TYR M 475
SER M 488
 None
 0.90A 4at0A-4wj3M:
undetectable		 4at0A-4wj3M:
24.33
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ysl BETA-LACTAMASE
DOMAIN PROTEIN

(Pseudomonas
putida) 		PF00753
(Lactamase_B) 		3 GLU A  15
TYR A  13
SER A  18
 None
 0.88A 4at0A-4yslA:
undetectable		 4at0A-4yslA:
19.81
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5b4x REELIN

(Mus musculus) 		PF07974
(EGF_2) 		3 GLU A2091
TYR A2080
SER A2078
 None
 0.91A 4at0A-5b4xA:
undetectable		 4at0A-5b4xA:
20.41
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5c16 MYOTUBULARIN-RELATED
PROTEIN 1

(Homo sapiens) 		PF02893
(GRAM)
PF06602
(Myotub-related) 		3 GLU A 321
TYR A 364
SER A 360
 None
 0.94A 4at0A-5c16A:
undetectable		 4at0A-5c16A:
21.99
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5f5n MONOOXYGENASE

(Micromonospora
sp. TP-A0468) 		PF05368
(NmrA) 		3 GLU A 133
TYR A 111
SER A 112
 None
 0.83A 4at0A-5f5nA:
3.5		 4at0A-5f5nA:
23.06
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5hr4 MMEI

(Methylophilus
methylotrophus) 		no annotation 3 GLU C 751
TYR C 776
SER C 812
 None
 0.93A 4at0A-5hr4C:
undetectable		 4at0A-5hr4C:
19.27
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5iy2 BETA-LACTAMASE
OXA-143

(Acinetobacter
baumannii) 		PF00905
(Transpeptidase) 		3 GLU A  39
TYR A  66
SER A  64
 None
 0.96A 4at0A-5iy2A:
undetectable		 4at0A-5iy2A:
19.88
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ldd CCZ1
RAB SMALL MONOMERIC
GTPASE-LIKE PROTEIN

(Chaetomium
thermophilum;
Chaetomium
thermophilum) 		PF08217
(DUF1712)
PF00071
(Ras) 		3 GLU B 113
TYR C  37
SER C  36
 None
 1.00A 4at0A-5lddB:
undetectable		 4at0A-5lddB:
19.14
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5mqs BETA-L-ARABINOBIOSID
ASE

(Bacteroides
thetaiotaomicron) 		PF13088
(BNR_2) 		3 GLU A 656
TYR A 624
SER A 628
 None
 0.85A 4at0A-5mqsA:
undetectable		 4at0A-5mqsA:
19.07
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5n4c PROLYL
OLIGOPEPTIDASE

(Galerina
marginata) 		no annotation 3 GLU A 291
TYR A 272
SER A 322
 None
 0.97A 4at0A-5n4cA:
undetectable		 4at0A-5n4cA:
21.50
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5nbs BETA-GLUCOSIDASE

(Neurospora
crassa) 		no annotation 3 GLU A 853
TYR A 842
SER A 786
 None
 0.87A 4at0A-5nbsA:
undetectable		 4at0A-5nbsA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5nth PUTATIVE
AMINOPEPTIDASE

(Leishmania
major) 		PF00883
(Peptidase_M17) 		3 GLU A 406
TYR A 401
SER A 502
 None
 1.00A 4at0A-5nthA:
undetectable		 4at0A-5nthA:
23.34
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5oih -

(-) 		no annotation 3 GLU A 401
TYR A 397
SER A 339
 None
 0.74A 4at0A-5oihA:
undetectable		 4at0A-5oihA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ojs TRANSCRIPTION-ASSOCI
ATED PROTEIN 1

(Saccharomyces
cerevisiae) 		PF00454
(PI3_PI4_kinase)
PF02259
(FAT) 		3 GLU T 681
TYR T 685
SER T 592
 None
 0.84A 4at0A-5ojsT:
undetectable		 4at0A-5ojsT:
8.34
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5oo7 SLA2

(Chaetomium
thermophilum) 		no annotation 3 GLU A 189
TYR A 252
SER A 193
 None
 1.00A 4at0A-5oo7A:
undetectable		 4at0A-5oo7A:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5t1j T-BOX TRANSCRIPTION
FACTOR TBX21

(Mus musculus) 		PF00907
(T-box) 		3 GLU A 274
TYR A 183
SER A 181
 None
 0.92A 4at0A-5t1jA:
undetectable		 4at0A-5t1jA:
17.49
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ta1 GLYCOSIDE HYDROLASE

(Bacteroides
uniformis) 		no annotation 3 GLU A  54
TYR A  56
SER A 372
 None
EDO  A 709 (-4.4A)
None
 0.99A 4at0A-5ta1A:
undetectable		 4at0A-5ta1A:
25.15
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5v57 SMOOTHENED
HOMOLOG,FLAVODOXIN,S
MOOTHENED HOMOLOG

(Desulfovibrio
vulgaris;
Homo sapiens) 		PF00258
(Flavodoxin_1)
PF01392
(Fz)
PF01534
(Frizzled) 		3 GLU A1099
TYR A1100
SER A1064
 None
 0.79A 4at0A-5v57A:
undetectable		 4at0A-5v57A:
21.44
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5vfd BETA-LACTAMASE

(Acinetobacter
baumannii) 		PF00905
(Transpeptidase) 		3 GLU A  39
TYR A  66
SER A  64
 None
 0.99A 4at0A-5vfdA:
undetectable		 4at0A-5vfdA:
19.60
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5xj4 PROGRAMMED CELL
DEATH 1 LIGAND 1

(Homo sapiens) 		no annotation 3 GLU A 223
TYR A 208
SER A 170
 None
 0.93A 4at0A-5xj4A:
undetectable		 4at0A-5xj4A:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5y7f UGGT

(Thermomyces
dupontii) 		PF01501
(Glyco_transf_8) 		3 GLU A1448
TYR A1452
SER A1213
 None
 0.92A 4at0A-5y7fA:
undetectable		 4at0A-5y7fA:
20.08
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5yg7 RIBOSE
1,5-BISPHOSPHATE
ISOMERASE

(Pyrococcus
horikoshii) 		no annotation 3 GLU A 237
TYR A 239
SER A  70
 RI2  A 401 ( 4.3A)
None
None
 0.94A 4at0A-5yg7A:
undetectable		 4at0A-5yg7A:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6ave ACID-SENSING ION
CHANNEL 1

(Gallus gallus) 		no annotation 3 GLU A 278
TYR A 371
SER A 252
 None
 0.84A 4at0A-6aveA:
undetectable		 4at0A-6aveA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6bqw BACTERIAL ACTIN ALFA

(Bacillus
subtilis) 		no annotation 3 GLU A  83
TYR A  55
SER A  35
 None
 0.95A 4at0A-6bqwA:
undetectable		 4at0A-6bqwA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6c26 DOLICHYL-DIPHOSPHOOL
IGOSACCHARIDE--PROTE
IN
GLYCOSYLTRANSFERASE
SUBUNIT SWP1

(Saccharomyces
cerevisiae) 		no annotation 3 GLU C  99
TYR C 109
SER C 107
 None
 1.01A 4at0A-6c26C:
undetectable		 4at0A-6c26C:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6ces RAS-RELATED
GTP-BINDING PROTEIN
C

(Homo sapiens) 		no annotation 3 GLU C 209
TYR C 165
SER C 162
 None
 0.98A 4at0A-6cesC:
undetectable		 4at0A-6cesC:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6czx PHOSPHOSERINE
AMINOTRANSFERASE 1,
CHLOROPLASTIC

(Arabidopsis
thaliana) 		no annotation 3 GLU A 135
TYR A 136
SER A 254
 None
 0.91A 4at0A-6czxA:
undetectable		 4at0A-6czxA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6f8y THREONYLCARBAMOYL-AM
P SYNTHASE

(Pyrococcus
abyssi) 		no annotation 3 GLU A 256
TYR A 277
SER A 276
 None
 0.86A 4at0A-6f8yA:
undetectable		 4at0A-6f8yA:
undetectable