SIMILAR PATTERNS OF AMINO ACIDS FOR 4ASD_A_BAXA1500_2
List of similar pattern of amino acids derived from ASSAM searchHit | Macromolecule/ Organism |
Pfam | Res. | Interface | HETATM | RMSD | Dali Z-score | Seq. Identity (%) | View | Dock | |
---|---|---|---|---|---|---|---|---|---|---|---|
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 1fiw | BETA-ACROSIN HEAVYCHAIN (Ovis aries) |
PF00089(Trypsin) | 4 | ILE A 118VAL A 31LEU A 33ILE A 65 | None | 0.89A | 4asdA-1fiwA:undetectable | 4asdA-1fiwA:21.96 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 1fiz | BETA-ACROSIN HEAVYCHAIN (Sus scrofa) |
PF00089(Trypsin) | 4 | ILE A 118VAL A 31LEU A 33ILE A 65 | None | 0.83A | 4asdA-1fizA:undetectable | 4asdA-1fizA:21.69 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 1fts | FTSY (Escherichiacoli) |
PF00448(SRP54)PF02881(SRP54_N) | 4 | ILE A 376VAL A 295LEU A 297ILE A 380 | None | 0.80A | 4asdA-1ftsA:undetectable | 4asdA-1ftsA:24.73 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 1guz | MALATE DEHYDROGENASE (Chlorobaculumtepidum;Prosthecochlorisvibrioformis) |
PF00056(Ldh_1_N)PF02866(Ldh_1_C) | 4 | ILE A 192VAL A 181LEU A 171CYH A 169 | None | 0.94A | 4asdA-1guzA:undetectable | 4asdA-1guzA:22.90 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 1h0h | FORMATEDEHYDROGENASESUBUNIT BETA (Desulfovibriogigas) |
PF13247(Fer4_11) | 4 | ILE B 141VAL B 101CYH B 80ILE B 93 | NoneSF4 B1013 ( 4.5A)SF4 B1013 (-2.3A)None | 0.92A | 4asdA-1h0hB:undetectable | 4asdA-1h0hB:20.40 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 1j8m | SIGNAL RECOGNITION54 KDA PROTEIN (Acidianusambivalens) |
PF00448(SRP54)PF02881(SRP54_N) | 4 | ILE F 97VAL F 129LEU F 131ILE F 184 | None | 0.80A | 4asdA-1j8mF:undetectable | 4asdA-1j8mF:23.10 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 1m2v | PROTEIN TRANSPORTPROTEIN SEC24 (Saccharomycescerevisiae) |
PF00626(Gelsolin)PF04810(zf-Sec23_Sec24)PF04811(Sec23_trunk)PF04815(Sec23_helical)PF08033(Sec23_BS) | 4 | ILE B 435VAL B 497LEU B 499ILE B 443 | None | 0.91A | 4asdA-1m2vB:undetectable | 4asdA-1m2vB:17.08 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 1ofe | FERREDOXIN-DEPENDENTGLUTAMATE SYNTHASE 2 (Synechocystissp. PCC 6803) |
PF00310(GATase_2)PF01493(GXGXG)PF01645(Glu_synthase)PF04898(Glu_syn_central) | 5 | ILE A 390VAL A 363LEU A 373ILE A 356CYH A 355 | None | 1.25A | 4asdA-1ofeA:undetectable | 4asdA-1ofeA:12.77 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 1pd1 | PROTEIN TRANSPORTPROTEIN SEC24 (Saccharomycescerevisiae) |
PF00626(Gelsolin)PF04810(zf-Sec23_Sec24)PF04811(Sec23_trunk)PF04815(Sec23_helical)PF08033(Sec23_BS) | 4 | ILE A 435VAL A 497LEU A 499ILE A 443 | None | 0.90A | 4asdA-1pd1A:undetectable | 4asdA-1pd1A:19.03 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 1pl8 | HUMAN SORBITOLDEHYDROGENASE (Homo sapiens) |
PF00107(ADH_zinc_N)PF08240(ADH_N) | 4 | ILE A 307VAL A 91LEU A 36CYH A 139 | None | 0.81A | 4asdA-1pl8A:undetectable | 4asdA-1pl8A:22.14 | ||
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target. | 1rjb | FL CYTOKINE RECEPTOR (Homo sapiens) |
PF07714(Pkinase_Tyr) | 5 | VAL A 675CYH A 694LEU A 818ILE A 827CYH A 828 | None | 0.55A | 4asdA-1rjbA:40.6 | 4asdA-1rjbA:47.80 | ||
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target. | 1t46 | HOMO SAPIENS V-KITHARDY-ZUCKERMAN 4FELINE SARCOMA VIRALONCOGENE HOMOLOG (Homo sapiens) |
PF07714(Pkinase_Tyr) | 5 | VAL A 654CYH A 673LEU A 799ILE A 808CYH A 809 | STI A 3 (-4.3A)STI A 3 (-4.5A)STI A 3 (-4.4A)NoneSTI A 3 (-4.5A) | 0.32A | 4asdA-1t46A:32.9 | 4asdA-1t46A:49.44 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 1tu2 | APOCYTOCHROME F (Nostoc sp. PCC7119) |
PF01333(Apocytochr_F_C)PF16639(Apocytochr_F_N) | 4 | ILE B 90VAL B 131LEU B 78ILE B 84 | None | 0.80A | 4asdA-1tu2B:undetectable | 4asdA-1tu2B:20.00 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 1w0h | 3'-5' EXONUCLEASEERI1 (Homo sapiens) |
PF00929(RNase_T) | 4 | VAL A 156LEU A 158ILE A 132CYH A 131 | None | 0.89A | 4asdA-1w0hA:undetectable | 4asdA-1w0hA:18.77 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 1wg1 | KIAA1579 PROTEIN (Homo sapiens) |
PF00076(RRM_1) | 4 | ILE A 146VAL A 99LEU A 102ILE A 160 | None | 0.94A | 4asdA-1wg1A:undetectable | 4asdA-1wg1A:13.49 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 1zlt | SERINE/THREONINE-PROTEIN KINASE CHK1 (Homo sapiens) |
PF00069(Pkinase) | 4 | VAL A 68CYH A 87LEU A 137ILE A 146 | HYM A 400 (-4.8A)HYM A 400 (-4.2A)HYM A 400 (-4.5A)None | 0.44A | 4asdA-1zltA:20.6 | 4asdA-1zltA:23.90 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 2bs9 | BETA-XYLOSIDASE (Geobacillusstearothermophilus) |
PF01229(Glyco_hydro_39) | 4 | ILE A 276LEU A 163ILE A 200CYH A 201 | None | 0.86A | 4asdA-2bs9A:undetectable | 4asdA-2bs9A:21.30 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 2fge | ZINC METALLOPROTEASE(INSULINASE FAMILY) (Arabidopsisthaliana) |
PF00675(Peptidase_M16)PF05193(Peptidase_M16_C)PF08367(M16C_assoc) | 4 | ILE A 470VAL A 302LEU A 300ILE A 363 | None | 0.92A | 4asdA-2fgeA:undetectable | 4asdA-2fgeA:17.06 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 2h5g | DELTA1-PYRROLINE-5-CARBOXYLATE SYNTHETASE (Homo sapiens) |
PF00171(Aldedh) | 4 | ILE A 552VAL A 478CYH A 486ILE A 479 | None | 0.93A | 4asdA-2h5gA:undetectable | 4asdA-2h5gA:22.81 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 2i80 | D-ALANINE-D-ALANINELIGASE (Staphylococcusaureus) |
PF01820(Dala_Dala_lig_N)PF07478(Dala_Dala_lig_C) | 4 | ILE A 338VAL A 91ILE A 8CYH A 7 | None | 0.89A | 4asdA-2i80A:undetectable | 4asdA-2i80A:23.32 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 2ixd | LMBE-RELATED PROTEIN (Bacillus cereus) |
PF02585(PIG-L) | 4 | ILE A 24CYH A 116LEU A 39CYH A 37 | None | 0.89A | 4asdA-2ixdA:undetectable | 4asdA-2ixdA:22.04 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 2jax | HYPOTHETICAL PROTEINTB31.7 (Mycobacteriumtuberculosis) |
PF00582(Usp) | 4 | ILE A 14VAL A 115LEU A 113ILE A 11 | None | 0.73A | 4asdA-2jaxA:undetectable | 4asdA-2jaxA:21.96 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 2jc6 | CALCIUM/CALMODULIN-DEPENDENT PROTEINKINASE TYPE 1D (Homo sapiens) |
PF00069(Pkinase) | 4 | ILE A 76VAL A 82LEU A 151ILE A 163 | None | 0.76A | 4asdA-2jc6A:20.4 | 4asdA-2jc6A:25.31 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 2ocx | NODULATIONFUCOSYLTRANSFERASENODZ (Bradyrhizobiumsp. WM9) |
PF05830(NodZ) | 4 | ILE A 301VAL A 201LEU A 198CYH A 202 | None | 0.92A | 4asdA-2ocxA:undetectable | 4asdA-2ocxA:19.69 | ||
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target. | 2ogv | MACROPHAGECOLONY-STIMULATINGFACTOR 1 RECEPTORPRECURSOR (Homo sapiens) |
PF07714(Pkinase_Tyr) | 4 | VAL A 647CYH A 666LEU A 785ILE A 794 | None | 0.49A | 4asdA-2ogvA:39.9 | 4asdA-2ogvA:48.31 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 2ohc | TRNA-SPLICINGENDONUCLEASE (Thermoplasmaacidophilum) |
PF01974(tRNA_int_endo) | 4 | VAL A 228LEU A 230ILE A 215CYH A 214 | None | 0.80A | 4asdA-2ohcA:undetectable | 4asdA-2ohcA:23.85 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 2pid | TYROSYL-TRNASYNTHETASE (Homo sapiens) |
PF00579(tRNA-synt_1b) | 4 | ILE A 251VAL A 271LEU A 47ILE A 269 | None | 0.90A | 4asdA-2pidA:undetectable | 4asdA-2pidA:23.76 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 2q50 | GLYOXYLATEREDUCTASE/HYDROXYPYRUVATE REDUCTASE (Homo sapiens) |
PF00389(2-Hacid_dh)PF02826(2-Hacid_dh_C) | 4 | ILE A 168VAL A 214CYH A 226ILE A 241 | None | 0.75A | 4asdA-2q50A:undetectable | 4asdA-2q50A:23.23 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 2q5o | PHENYLPYRUVATEDECARBOXYLASE (Azospirillumbrasilense) |
PF00205(TPP_enzyme_M)PF02775(TPP_enzyme_C)PF02776(TPP_enzyme_N) | 4 | ILE A 376VAL A 451LEU A 515ILE A 452 | None | 0.92A | 4asdA-2q5oA:undetectable | 4asdA-2q5oA:22.39 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 2r5r | UPF0343 PROTEINNE1163 (Nitrosomonaseuropaea) |
PF02649(GCHY-1) | 4 | ILE A 131VAL A 176LEU A 233ILE A 243 | None | 0.94A | 4asdA-2r5rA:undetectable | 4asdA-2r5rA:18.36 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 2x8x | TLR1789 PROTEIN (Thermosynechococcuselongatus) |
PF07244(POTRA)PF08479(POTRA_2) | 4 | ILE X 296VAL X 279LEU X 281ILE X 293 | None | 0.85A | 4asdA-2x8xX:undetectable | 4asdA-2x8xX:21.90 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 2xe4 | OLIGOPEPTIDASE B (Leishmaniamajor) |
PF00326(Peptidase_S9)PF02897(Peptidase_S9_N) | 4 | VAL A 277LEU A 279ILE A 267CYH A 266 | None | 0.85A | 4asdA-2xe4A:undetectable | 4asdA-2xe4A:19.16 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3a0f | XYLOGLUCANASE (Geotrichum sp.M128) |
no annotation | 4 | ILE A 439VAL A 8ILE A 749CYH A 750 | None | 0.86A | 4asdA-3a0fA:undetectable | 4asdA-3a0fA:18.67 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3a76 | GAMMA-HEXACHLOROCYCLOHEXANEDEHYDROCHLORINASE (Sphingomonaspaucimobilis) |
PF13577(SnoaL_4) | 4 | ILE A 72VAL A 24LEU A 32ILE A 22 | None | 0.79A | 4asdA-3a76A:undetectable | 4asdA-3a76A:21.78 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3a9v | 4-COUMARATE--COALIGASE (Populustomentosa) |
PF00501(AMP-binding)PF13193(AMP-binding_C) | 4 | ILE A 252VAL A 272LEU A 299ILE A 274 | None | 0.74A | 4asdA-3a9vA:undetectable | 4asdA-3a9vA:22.83 | ||
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target. | 3hng | VASCULAR ENDOTHELIALGROWTH FACTORRECEPTOR 1 (Homo sapiens) |
PF07714(Pkinase_Tyr) | 6 | ILE A 885VAL A 892CYH A 912LEU A1029ILE A1038CYH A1039 | None8ST A2001 ( 4.7A)8ST A2001 (-3.8A)NoneNone8ST A2001 (-4.2A) | 0.54A | 4asdA-3hngA:44.3 | 4asdA-3hngA:67.22 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3hps | 2-ISOPROPYLMALATESYNTHASE (Mycobacteriumtuberculosis) |
PF00682(HMGL-like)PF08502(LeuA_dimer) | 4 | ILE A 239VAL A 280LEU A 282ILE A 248 | None | 0.87A | 4asdA-3hpsA:undetectable | 4asdA-3hpsA:18.67 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3ibs | CONSERVEDHYPOTHETICAL PROTEINBATB (Bacteroidesthetaiotaomicron) |
PF00092(VWA) | 4 | ILE A 203VAL A 47LEU A 60ILE A 10 | None | 0.81A | 4asdA-3ibsA:undetectable | 4asdA-3ibsA:19.53 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3nkl | UDP-D-QUINOVOSAMINE4-DEHYDROGENASE (Aliivibriofischeri) |
PF02629(CoA_binding) | 4 | ILE A 29VAL A 66LEU A 68ILE A 6 | None | 0.84A | 4asdA-3nklA:undetectable | 4asdA-3nklA:18.36 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3qe3 | SORBITOLDEHYDROGENASE (Ovis aries) |
PF00107(ADH_zinc_N)PF08240(ADH_N) | 4 | ILE A 306VAL A 90LEU A 35CYH A 138 | None | 0.91A | 4asdA-3qe3A:undetectable | 4asdA-3qe3A:21.98 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3s29 | SUCROSE SYNTHASE 1 (Arabidopsisthaliana) |
PF00534(Glycos_transf_1)PF00862(Sucrose_synth) | 4 | ILE A 43VAL A 86LEU A 88ILE A 80 | None | 0.88A | 4asdA-3s29A:undetectable | 4asdA-3s29A:16.97 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3s5c | LINA (unculturedorganism) |
no annotation | 4 | ILE B 72VAL B 24LEU B 32ILE B 22 | None | 0.88A | 4asdA-3s5cB:undetectable | 4asdA-3s5cB:18.39 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3sth | GLYCERALDEHYDE-3-PHOSPHATE DEHYDROGENASE (Toxoplasmagondii) |
PF00044(Gp_dh_N)PF02800(Gp_dh_C) | 4 | ILE A 146CYH A 3LEU A 5ILE A 94 | None | 0.89A | 4asdA-3sthA:undetectable | 4asdA-3sthA:25.37 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3uyk | NDP-RHAMNOSYLTRANSFERASE (Saccharopolysporaspinosa) |
PF06722(DUF1205) | 4 | ILE A 349VAL A 289ILE A 222CYH A 221 | None | 0.86A | 4asdA-3uykA:undetectable | 4asdA-3uykA:22.44 | ||
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target. | 3vid | VASCULAR ENDOTHELIALGROWTH FACTORRECEPTOR 2 (Homo sapiens) |
PF07714(Pkinase_Tyr) | 6 | ILE A 892VAL A 899CYH A 919LEU A1035ILE A1044CYH A1045 | NoneNone4TT A2001 (-4.3A)4TT A2001 (-4.8A)NoneNone | 0.37A | 4asdA-3vidA:39.8 | 4asdA-3vidA:85.96 | ||
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target. | 3wzd | VASCULAR ENDOTHELIALGROWTH FACTORRECEPTOR 2 (Homo sapiens) |
PF07714(Pkinase_Tyr) | 6 | ILE A 892VAL A 899CYH A 919LEU A1035ILE A1044CYH A1045 | NoneNoneLEV A1201 (-4.1A)LEV A1201 (-4.8A)NoneGOL A1210 ( 3.3A) | 0.39A | 4asdA-3wzdA:38.3 | 4asdA-3wzdA:100.00 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4a4i | PROTEIN LIN-28HOMOLOG B (Homo sapiens) |
PF00313(CSD) | 5 | ILE A 49VAL A 83CYH A 107LEU A 77CYH A 34 | None | 1.44A | 4asdA-4a4iA:undetectable | 4asdA-4a4iA:13.94 | ||
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target. | 4agd | VASCULAR ENDOTHELIALGROWTH FACTORRECEPTOR 2 (Homo sapiens) |
PF07714(Pkinase_Tyr) | 6 | ILE A 892VAL A 899CYH A 919LEU A1035ILE A1044CYH A1045 | NoneB49 A2000 ( 4.6A)B49 A2000 (-4.2A)B49 A2000 (-4.5A)NoneB49 A2000 ( 4.1A) | 0.36A | 4asdA-4agdA:34.3 | 4asdA-4agdA:100.00 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4agu | CYCLIN-DEPENDENTKINASE-LIKE 1 (Homo sapiens) |
PF00069(Pkinase) | 4 | VAL A 64CYH A 83LEU A 133CYH A 143 | NoneD15 A 500 (-4.3A)D15 A 500 (-4.5A)D15 A 500 ( 4.0A) | 0.28A | 4asdA-4aguA:22.5 | 4asdA-4aguA:25.43 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4c95 | DNA POLYMERASEALPHA-BINDINGPROTEIN (Saccharomycescerevisiae) |
PF12341(Mcl1_mid) | 4 | ILE A 615VAL A 581LEU A 545ILE A 589 | None | 0.84A | 4asdA-4c95A:undetectable | 4asdA-4c95A:22.04 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4ci8 | ECHINODERMMICROTUBULE-ASSOCIATED PROTEIN-LIKE 1 (Homo sapiens) |
PF00400(WD40)PF03451(HELP) | 4 | ILE A 463VAL A 475LEU A 469CYH A 467 | None | 0.93A | 4asdA-4ci8A:undetectable | 4asdA-4ci8A:19.79 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4cok | PYRUVATEDECARBOXYLASE (Gluconacetobacterdiazotrophicus) |
PF00205(TPP_enzyme_M)PF02775(TPP_enzyme_C)PF02776(TPP_enzyme_N) | 4 | VAL A 304LEU A 306ILE A 281CYH A 282 | None | 0.91A | 4asdA-4cokA:undetectable | 4asdA-4cokA:20.63 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4cs6 | AMINOGLYCOSIDEADENYLTRANSFERASE (Salmonellaenterica) |
PF01909(NTP_transf_2)PF13427(DUF4111) | 4 | ILE A 48VAL A 38LEU A 3ILE A 5 | None | 0.90A | 4asdA-4cs6A:undetectable | 4asdA-4cs6A:20.49 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4d7a | TRNATHREONYLCARBAMOYLADENOSINE DEHYDRATASE (Escherichiacoli) |
PF00899(ThiF) | 4 | ILE A 38CYH A 142LEU A 149ILE A 126 | NoneNoneGOL A 502 (-4.7A)None | 0.87A | 4asdA-4d7aA:undetectable | 4asdA-4d7aA:21.95 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4dgj | ENTEROPEPTIDASECATALYTIC LIGHTCHAIN (Homo sapiens) |
PF00089(Trypsin) | 4 | ILE A 108VAL A 16LEU A 18ILE A 56 | None | 0.85A | 4asdA-4dgjA:undetectable | 4asdA-4dgjA:20.11 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4fg8 | CALCIUM/CALMODULIN-DEPENDENT PROTEINKINASE TYPE 1 (Homo sapiens) |
PF00069(Pkinase) | 4 | ILE A 73VAL A 79LEU A 148ILE A 160 | NoneATP A 401 (-4.7A)ATP A 401 (-4.6A)None | 0.65A | 4asdA-4fg8A:21.2 | 4asdA-4fg8A:26.61 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4ghb | HYPOTHETICAL PROTEIN (Bacteroidesuniformis) |
PF15283(DUF4595) | 4 | ILE A 65VAL A 285LEU A 279ILE A 284 | None | 0.93A | 4asdA-4ghbA:undetectable | 4asdA-4ghbA:22.07 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4gps | KLLA0E02245P (Kluyveromyceslactis) |
no annotation | 4 | ILE A 190CYH A 44LEU A 42ILE A 392 | None | 0.89A | 4asdA-4gpsA:undetectable | 4asdA-4gpsA:24.27 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4h37 | LMO2059 PROTEIN (Listeriamonocytogenes) |
PF07885(Ion_trans_2) | 4 | ILE A 29VAL A 24LEU A 20ILE A 22 | None | 0.76A | 4asdA-4h37A:undetectable | 4asdA-4h37A:16.76 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4hv4 | UDP-N-ACETYLMURAMATE--L-ALANINE LIGASE (Yersinia pestis) |
PF01225(Mur_ligase)PF02875(Mur_ligase_C)PF08245(Mur_ligase_M) | 4 | ILE A 247VAL A 236ILE A 231CYH A 230 | None | 0.92A | 4asdA-4hv4A:undetectable | 4asdA-4hv4A:21.40 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4iao | NAD-DEPENDENTHISTONE DEACETYLASESIR2 (Saccharomycescerevisiae) |
PF02146(SIR2)PF04574(DUF592) | 4 | ILE A 516LEU A 260ILE A 468CYH A 469 | None | 0.75A | 4asdA-4iaoA:undetectable | 4asdA-4iaoA:22.60 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4l52 | MITOGEN-ACTIVATEDPROTEIN KINASEKINASE KINASE 7,TGF-BETA-ACTIVATEDKINASE 1 ANDMAP3K7-BINDINGPROTEIN 1 CHIMERA (Homo sapiens) |
PF07714(Pkinase_Tyr) | 4 | VAL A 90LEU A 163ILE A 173CYH A 174 | None1UL A 501 (-4.3A)None1UL A 501 (-3.6A) | 0.29A | 4asdA-4l52A:19.9 | 4asdA-4l52A:28.01 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4o38 | CYCLIN-G-ASSOCIATEDKINASE (Homo sapiens) |
PF00069(Pkinase) | 4 | VAL A 99CYH A 126LEU A 180CYH A 190 | NoneSIN A 401 (-4.3A)SIN A 401 ( 4.5A)None | 0.52A | 4asdA-4o38A:20.1 | 4asdA-4o38A:24.56 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4p1c | TOLUENE-4-MONOOXYGENASE SYSTEM PROTEIN A (Pseudomonasmendocina) |
PF02332(Phenol_Hydrox) | 5 | ILE A 170VAL A 396LEU A 404ILE A 402CYH A 397 | None | 1.41A | 4asdA-4p1cA:undetectable | 4asdA-4p1cA:19.84 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4pw0 | ALPHA/BETA HYDROLASEFOLD PROTEIN (Chitinophagapinensis) |
PF00561(Abhydrolase_1) | 4 | ILE A 124LEU A 63ILE A 37CYH A 38 | None | 0.92A | 4asdA-4pw0A:undetectable | 4asdA-4pw0A:21.53 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4qtb | MITOGEN-ACTIVATEDPROTEIN KINASE 3 (Homo sapiens) |
PF00069(Pkinase) | 4 | ILE A 91LEU A 173ILE A 182CYH A 183 | None38Z A 418 (-4.4A)None38Z A 418 ( 3.8A) | 0.81A | 4asdA-4qtbA:21.1 | 4asdA-4qtbA:26.45 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4r72 | ABC-TYPE FE3+TRANSPORT SYSTEM,PERIPLASMICCOMPONENT (Actinobacilluspleuropneumoniae) |
PF13343(SBP_bac_6) | 4 | ILE A 155VAL A 312LEU A 317ILE A 315 | None | 0.89A | 4asdA-4r72A:undetectable | 4asdA-4r72A:18.08 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4rhe | 3-OCTAPRENYL-4-HYDROXYBENZOATECARBOXY-LYASE (Colwelliapsychrerythraea) |
PF02441(Flavoprotein) | 4 | ILE A 122LEU A 25ILE A 13CYH A 103 | None | 0.89A | 4asdA-4rheA:undetectable | 4asdA-4rheA:20.23 | ||
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target. | 4rt7 | RECEPTOR-TYPETYROSINE-PROTEINKINASE FLT3 (Homo sapiens) |
PF07714(Pkinase_Tyr) | 5 | VAL A 675CYH A 694LEU A 818ILE A 827CYH A 828 | NoneNoneP30 A1001 (-4.6A)P30 A1001 ( 4.8A)P30 A1001 (-4.1A) | 0.36A | 4asdA-4rt7A:32.2 | 4asdA-4rt7A:43.33 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4w7s | PRE-MRNA-SPLICINGATP-DEPENDENT RNAHELICASE PRP28 (Saccharomycescerevisiae) |
PF00270(DEAD)PF00271(Helicase_C) | 4 | ILE A 443VAL A 510LEU A 508ILE A 440 | None | 0.91A | 4asdA-4w7sA:undetectable | 4asdA-4w7sA:21.38 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4wsq | AP2-ASSOCIATEDPROTEIN KINASE 1 (Homo sapiens) |
PF00069(Pkinase) | 4 | VAL A 104CYH A 129LEU A 183CYH A 193 | NoneKSA A 405 (-4.5A)KSA A 405 (-4.6A)KSA A 405 (-3.4A) | 0.51A | 4asdA-4wsqA:22.6 | 4asdA-4wsqA:24.38 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4xgj | UNCHARACTERIZEDPROTEIN (Pectobacteriumatrosepticum) |
PF07005(DUF1537)PF17042(DUF1357_C) | 4 | ILE A 91VAL A 14LEU A 12ILE A 88 | None | 0.86A | 4asdA-4xgjA:undetectable | 4asdA-4xgjA:22.46 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4xr7 | PAB-DEPENDENTPOLY(A)-SPECIFICRIBONUCLEASE SUBUNITPAN3 (Saccharomycescerevisiae) |
no annotation | 4 | ILE L 349VAL L 412LEU L 409ILE L 423 | None | 0.92A | 4asdA-4xr7L:12.9 | 4asdA-4xr7L:18.75 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4xrl | MITOGEN-ACTIVATEDPROTEIN KINASE 1 (Rattusnorvegicus) |
PF00069(Pkinase) | 4 | ILE A 72LEU A 154ILE A 163CYH A 164 | None42A A 402 ( 4.9A)NoneNone | 0.87A | 4asdA-4xrlA:20.9 | 4asdA-4xrlA:25.71 | ||
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target. | 4xuf | RECEPTOR-TYPETYROSINE-PROTEINKINASE FLT3 (Homo sapiens) |
PF07714(Pkinase_Tyr) | 5 | VAL A 675CYH A 694LEU A 818ILE A 827CYH A 828 | NoneP30 A1001 (-4.2A)P30 A1001 (-4.3A)P30 A1001 (-4.7A)P30 A1001 (-4.8A) | 0.24A | 4asdA-4xufA:39.0 | 4asdA-4xufA:51.75 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4zdk | CTP SYNTHASE (Mycobacteriumtuberculosis) |
PF00117(GATase)PF06418(CTP_synth_N) | 4 | ILE A 488LEU A 394ILE A 399CYH A 398 | NoneONL A 601 ( 4.1A)NoneNone | 0.79A | 4asdA-4zdkA:undetectable | 4asdA-4zdkA:20.50 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 5b04 | PROBABLE TRANSLATIONINITIATION FACTOREIF-2B SUBUNIT DELTA (Schizosaccharomycespombe) |
PF01008(IF-2B) | 5 | ILE G 332VAL G 298CYH G 310LEU G 314CYH G 321 | None | 1.49A | 4asdA-5b04G:3.1 | 4asdA-5b04G:21.21 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 5ci6 | MITOGEN-ACTIVATEDPROTEIN KINASE 6 (Arabidopsisthaliana) |
PF00069(Pkinase) | 4 | VAL A 123LEU A 196ILE A 205CYH A 206 | None | 0.28A | 4asdA-5ci6A:20.2 | 4asdA-5ci6A:24.94 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 5ci7 | SERINE/THREONINE-PROTEIN KINASE ULK1 (Homo sapiens) |
PF00069(Pkinase) | 4 | VAL A 76CYH A 95LEU A 145ILE A 163 | None51W A 401 (-3.9A)51W A 401 (-4.5A)None | 0.42A | 4asdA-5ci7A:23.3 | 4asdA-5ci7A:26.50 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 5cyp | SEPTIN-9 (Homo sapiens) |
PF00735(Septin) | 4 | ILE A 273VAL A 162LEU A 158CYH A 136 | None | 0.91A | 4asdA-5cypA:undetectable | 4asdA-5cypA:23.90 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 5dl2 | REGULATOR OFPROTEASE B (ROPB) (Streptococcuspyogenes) |
no annotation | 4 | VAL A 250LEU A 272ILE A 252CYH A 249 | None | 0.86A | 4asdA-5dl2A:undetectable | 4asdA-5dl2A:22.32 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 5eaw | DNA REPLICATIONATP-DEPENDENTHELICASE/NUCLEASEDNA2 (Mus musculus) |
PF08696(Dna2)PF13086(AAA_11)PF13087(AAA_12) | 5 | ILE A 647VAL A 762CYH A 744ILE A 761CYH A 760 | None | 1.34A | 4asdA-5eawA:2.9 | 4asdA-5eawA:16.86 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 5eus | PRESTIN,RAT PRESTINSTAS DOMAIN (Rattusnorvegicus) |
PF01740(STAS) | 4 | ILE A 639VAL A 674LEU A 676ILE A 643 | None | 0.80A | 4asdA-5eusA:undetectable | 4asdA-5eusA:15.25 | ||
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target. | 5grn | PLATELET-DERIVEDGROWTH FACTORRECEPTOR ALPHA (Homo sapiens) |
PF07714(Pkinase_Tyr) | 5 | VAL A 658CYH A 677LEU A 825ILE A 834CYH A 835 | 748 A1001 ( 4.8A)748 A1001 (-4.5A)748 A1001 (-4.3A)748 A1001 (-4.8A)748 A1001 (-4.5A) | 0.27A | 4asdA-5grnA:42.2 | 4asdA-5grnA:48.40 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 5i3o | BMP-2-INDUCIBLEPROTEIN KINASE (Homo sapiens) |
PF00069(Pkinase) | 4 | VAL A 109CYH A 133LEU A 187CYH A 197 | NoneIDV A 401 (-4.6A)IDV A 401 (-4.4A)IDV A 401 (-3.6A) | 0.40A | 4asdA-5i3oA:4.9 | 4asdA-5i3oA:22.77 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 5irr | SEPTIN-LIKE PROTEIN (Chlamydomonasreinhardtii) |
PF00735(Septin) | 4 | ILE A 376VAL A 255LEU A 251CYH A 231 | None | 0.84A | 4asdA-5irrA:undetectable | 4asdA-5irrA:20.60 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 5j46 | PEPTIDE DEFORMYLASE (Burkholderiamultivorans) |
PF01327(Pep_deformylase) | 4 | VAL A 144LEU A 141ILE A 146CYH A 145 | None | 0.84A | 4asdA-5j46A:undetectable | 4asdA-5j46A:19.61 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 5j4g | UNCHARACTERIZEDPROTEIN (Helicobacterpylori) |
no annotation | 4 | ILE A 57VAL A 91ILE A 31CYH A 32 | None | 0.94A | 4asdA-5j4gA:undetectable | 4asdA-5j4gA:15.32 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 5jxr | CHROMATIN-REMODELINGCOMPLEX ATPASE-LIKEPROTEIN (Thermothelomycesthermophila) |
PF00176(SNF2_N)PF00271(Helicase_C) | 4 | ILE A 312LEU A 266ILE A 290CYH A 289 | None | 0.87A | 4asdA-5jxrA:undetectable | 4asdA-5jxrA:17.26 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 5m0y | CELLULOSOMEANCHORING PROTEINCOHESIN REGIONIG DOMAIN PROTEINGROUP 2 DOMAINPROTEIN (Ruminiclostridiumthermocellum) |
PF00963(Cohesin)no annotation | 4 | ILE A 95VAL B 153LEU B 139ILE B 150 | None | 0.89A | 4asdA-5m0yA:undetectable | 4asdA-5m0yA:18.96 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 5mj7 | UNCHARACTERIZEDPROTEIN (Caenorhabditiselegans) |
PF01156(IU_nuc_hydro) | 4 | ILE A 64VAL A 9LEU A 130ILE A 10 | None | 0.93A | 4asdA-5mj7A:undetectable | 4asdA-5mj7A:24.00 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 5o0y | SERINE/THREONINE-PROTEIN KINASETOUSLED-LIKE 2 (Homo sapiens) |
no annotation | 4 | VAL A 527CYH A 547LEU A 599ILE A 611 | NoneAGS A 801 (-4.3A)NoneNone | 0.87A | 4asdA-5o0yA:20.3 | 4asdA-5o0yA:13.66 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 5oy0 | PHOTOSYSTEM I P700CHLOROPHYLL AAPOPROTEIN A1 (Synechocystissp. PCC 6803) |
no annotation | 4 | VAL 1 443LEU 1 440ILE 1 445CYH 1 444 | CLA 1 838 (-4.9A)CLA 1 838 (-3.5A)CLA 1 832 (-4.1A)None | 0.93A | 4asdA-5oy01:undetectable | 4asdA-5oy01:14.06 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 5ux5 | BIFUNCTIONAL PROTEINPROLINE UTILIZATIONA (PUTA) (Corynebacteriumfreiburgense) |
PF00171(Aldedh)PF01619(Pro_dh) | 4 | ILE A 875VAL A 729LEU A 731ILE A 697 | None | 0.90A | 4asdA-5ux5A:undetectable | 4asdA-5ux5A:15.84 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 5v2m | MEVALONATEDIPHOSPHATEDECARBOXYLASE (Enterococcusfaecalis) |
no annotation | 4 | ILE A 235VAL A 289LEU A 299CYH A 277 | None | 0.79A | 4asdA-5v2mA:undetectable | 4asdA-5v2mA:22.05 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 5xfm | ALPHA-GLUCOSIDASE (Bacteroidesthetaiotaomicron) |
no annotation | 4 | VAL A 609LEU A 611ILE A 646CYH A 645 | None | 0.83A | 4asdA-5xfmA:undetectable | 4asdA-5xfmA:14.98 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 5xxu | RIBOSOMAL PROTEINUS2 (Toxoplasmagondii) |
PF00318(Ribosomal_S2) | 4 | ILE A 124VAL A 158ILE A 160CYH A 161 | None | 0.90A | 4asdA-5xxuA:undetectable | 4asdA-5xxuA:20.28 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 6d6q | EXOSOME COMPLEXEXONUCLEASE RRP44 (Homo sapiens) |
no annotation | 4 | ILE K 582VAL K 504ILE K 563CYH K 562 | None | 0.92A | 4asdA-6d6qK:undetectable | 4asdA-6d6qK:15.24 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 6fdy | - (-) |
no annotation | 4 | ILE U 69VAL U 75CYH U 94LEU U 144 | NoneDB8 U 301 (-4.8A)DB8 U 301 (-4.2A)DB8 U 301 (-4.8A) | 0.75A | 4asdA-6fdyU:20.8 | 4asdA-6fdyU:undetectable | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 6ft1 | FLAVODOXIN (Bacillus cereus) |
no annotation | 4 | ILE A 33VAL A 25LEU A 137ILE A 22 | None | 0.92A | 4asdA-6ft1A:undetectable | 4asdA-6ft1A:12.17 |