SIMILAR PATTERNS OF AMINO ACIDS FOR 4ASD_A_BAXA1500_2

List of similar pattern of amino acids derived from ASSAM search

Hit pattern: 3D amino acid arrangements similar to known drug binding site

Query pattern: Residues from known binding site for annotated drug that match the hit pattern


(Click link on the last column to view superposed patterns of amino acids in NGL viewer)
(Note that only 3-12 residue patterns can be used for ASSAM searches)
Filter list by:
Hit Macromolecule/
Organism
Pfam Res. Interface HETATM RMSD Dali Z-score Seq. Identity (%) View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1fiw BETA-ACROSIN HEAVY
CHAIN


(Ovis aries)
PF00089
(Trypsin)
4 ILE A 118
VAL A  31
LEU A  33
ILE A  65
None
0.89A 4asdA-1fiwA:
undetectable
4asdA-1fiwA:
21.96
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1fiz BETA-ACROSIN HEAVY
CHAIN


(Sus scrofa)
PF00089
(Trypsin)
4 ILE A 118
VAL A  31
LEU A  33
ILE A  65
None
0.83A 4asdA-1fizA:
undetectable
4asdA-1fizA:
21.69
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1fts FTSY

(Escherichia
coli)
PF00448
(SRP54)
PF02881
(SRP54_N)
4 ILE A 376
VAL A 295
LEU A 297
ILE A 380
None
0.80A 4asdA-1ftsA:
undetectable
4asdA-1ftsA:
24.73
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1guz MALATE DEHYDROGENASE

(Chlorobaculum
tepidum;
Prosthecochloris
vibrioformis)
PF00056
(Ldh_1_N)
PF02866
(Ldh_1_C)
4 ILE A 192
VAL A 181
LEU A 171
CYH A 169
None
0.94A 4asdA-1guzA:
undetectable
4asdA-1guzA:
22.90
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1h0h FORMATE
DEHYDROGENASE
SUBUNIT BETA


(Desulfovibrio
gigas)
PF13247
(Fer4_11)
4 ILE B 141
VAL B 101
CYH B  80
ILE B  93
None
SF4  B1013 ( 4.5A)
SF4  B1013 (-2.3A)
None
0.92A 4asdA-1h0hB:
undetectable
4asdA-1h0hB:
20.40
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1j8m SIGNAL RECOGNITION
54 KDA PROTEIN


(Acidianus
ambivalens)
PF00448
(SRP54)
PF02881
(SRP54_N)
4 ILE F  97
VAL F 129
LEU F 131
ILE F 184
None
0.80A 4asdA-1j8mF:
undetectable
4asdA-1j8mF:
23.10
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1m2v PROTEIN TRANSPORT
PROTEIN SEC24


(Saccharomyces
cerevisiae)
PF00626
(Gelsolin)
PF04810
(zf-Sec23_Sec24)
PF04811
(Sec23_trunk)
PF04815
(Sec23_helical)
PF08033
(Sec23_BS)
4 ILE B 435
VAL B 497
LEU B 499
ILE B 443
None
0.91A 4asdA-1m2vB:
undetectable
4asdA-1m2vB:
17.08
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ofe FERREDOXIN-DEPENDENT
GLUTAMATE SYNTHASE 2


(Synechocystis
sp. PCC 6803)
PF00310
(GATase_2)
PF01493
(GXGXG)
PF01645
(Glu_synthase)
PF04898
(Glu_syn_central)
5 ILE A 390
VAL A 363
LEU A 373
ILE A 356
CYH A 355
None
1.25A 4asdA-1ofeA:
undetectable
4asdA-1ofeA:
12.77
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1pd1 PROTEIN TRANSPORT
PROTEIN SEC24


(Saccharomyces
cerevisiae)
PF00626
(Gelsolin)
PF04810
(zf-Sec23_Sec24)
PF04811
(Sec23_trunk)
PF04815
(Sec23_helical)
PF08033
(Sec23_BS)
4 ILE A 435
VAL A 497
LEU A 499
ILE A 443
None
0.90A 4asdA-1pd1A:
undetectable
4asdA-1pd1A:
19.03
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1pl8 HUMAN SORBITOL
DEHYDROGENASE


(Homo sapiens)
PF00107
(ADH_zinc_N)
PF08240
(ADH_N)
4 ILE A 307
VAL A  91
LEU A  36
CYH A 139
None
0.81A 4asdA-1pl8A:
undetectable
4asdA-1pl8A:
22.14
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1rjb FL CYTOKINE RECEPTOR

(Homo sapiens)
PF07714
(Pkinase_Tyr)
5 VAL A 675
CYH A 694
LEU A 818
ILE A 827
CYH A 828
None
0.55A 4asdA-1rjbA:
40.6
4asdA-1rjbA:
47.80
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1t46 HOMO SAPIENS V-KIT
HARDY-ZUCKERMAN 4
FELINE SARCOMA VIRAL
ONCOGENE HOMOLOG


(Homo sapiens)
PF07714
(Pkinase_Tyr)
5 VAL A 654
CYH A 673
LEU A 799
ILE A 808
CYH A 809
STI  A   3 (-4.3A)
STI  A   3 (-4.5A)
STI  A   3 (-4.4A)
None
STI  A   3 (-4.5A)
0.32A 4asdA-1t46A:
32.9
4asdA-1t46A:
49.44
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1tu2 APOCYTOCHROME F

(Nostoc sp. PCC
7119)
PF01333
(Apocytochr_F_C)
PF16639
(Apocytochr_F_N)
4 ILE B  90
VAL B 131
LEU B  78
ILE B  84
None
0.80A 4asdA-1tu2B:
undetectable
4asdA-1tu2B:
20.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1w0h 3'-5' EXONUCLEASE
ERI1


(Homo sapiens)
PF00929
(RNase_T)
4 VAL A 156
LEU A 158
ILE A 132
CYH A 131
None
0.89A 4asdA-1w0hA:
undetectable
4asdA-1w0hA:
18.77
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1wg1 KIAA1579 PROTEIN

(Homo sapiens)
PF00076
(RRM_1)
4 ILE A 146
VAL A  99
LEU A 102
ILE A 160
None
0.94A 4asdA-1wg1A:
undetectable
4asdA-1wg1A:
13.49
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1zlt SERINE/THREONINE-PRO
TEIN KINASE CHK1


(Homo sapiens)
PF00069
(Pkinase)
4 VAL A  68
CYH A  87
LEU A 137
ILE A 146
HYM  A 400 (-4.8A)
HYM  A 400 (-4.2A)
HYM  A 400 (-4.5A)
None
0.44A 4asdA-1zltA:
20.6
4asdA-1zltA:
23.90
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2bs9 BETA-XYLOSIDASE

(Geobacillus
stearothermophilus)
PF01229
(Glyco_hydro_39)
4 ILE A 276
LEU A 163
ILE A 200
CYH A 201
None
0.86A 4asdA-2bs9A:
undetectable
4asdA-2bs9A:
21.30
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2fge ZINC METALLOPROTEASE
(INSULINASE FAMILY)


(Arabidopsis
thaliana)
PF00675
(Peptidase_M16)
PF05193
(Peptidase_M16_C)
PF08367
(M16C_assoc)
4 ILE A 470
VAL A 302
LEU A 300
ILE A 363
None
0.92A 4asdA-2fgeA:
undetectable
4asdA-2fgeA:
17.06
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2h5g DELTA
1-PYRROLINE-5-CARBOX
YLATE SYNTHETASE


(Homo sapiens)
PF00171
(Aldedh)
4 ILE A 552
VAL A 478
CYH A 486
ILE A 479
None
0.93A 4asdA-2h5gA:
undetectable
4asdA-2h5gA:
22.81
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2i80 D-ALANINE-D-ALANINE
LIGASE


(Staphylococcus
aureus)
PF01820
(Dala_Dala_lig_N)
PF07478
(Dala_Dala_lig_C)
4 ILE A 338
VAL A  91
ILE A   8
CYH A   7
None
0.89A 4asdA-2i80A:
undetectable
4asdA-2i80A:
23.32
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2ixd LMBE-RELATED PROTEIN

(Bacillus cereus)
PF02585
(PIG-L)
4 ILE A  24
CYH A 116
LEU A  39
CYH A  37
None
0.89A 4asdA-2ixdA:
undetectable
4asdA-2ixdA:
22.04
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2jax HYPOTHETICAL PROTEIN
TB31.7


(Mycobacterium
tuberculosis)
PF00582
(Usp)
4 ILE A  14
VAL A 115
LEU A 113
ILE A  11
None
0.73A 4asdA-2jaxA:
undetectable
4asdA-2jaxA:
21.96
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2jc6 CALCIUM/CALMODULIN-D
EPENDENT PROTEIN
KINASE TYPE 1D


(Homo sapiens)
PF00069
(Pkinase)
4 ILE A  76
VAL A  82
LEU A 151
ILE A 163
None
0.76A 4asdA-2jc6A:
20.4
4asdA-2jc6A:
25.31
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2ocx NODULATION
FUCOSYLTRANSFERASE
NODZ


(Bradyrhizobium
sp. WM9)
PF05830
(NodZ)
4 ILE A 301
VAL A 201
LEU A 198
CYH A 202
None
0.92A 4asdA-2ocxA:
undetectable
4asdA-2ocxA:
19.69
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2ogv MACROPHAGE
COLONY-STIMULATING
FACTOR 1 RECEPTOR
PRECURSOR


(Homo sapiens)
PF07714
(Pkinase_Tyr)
4 VAL A 647
CYH A 666
LEU A 785
ILE A 794
None
0.49A 4asdA-2ogvA:
39.9
4asdA-2ogvA:
48.31
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2ohc TRNA-SPLICING
ENDONUCLEASE


(Thermoplasma
acidophilum)
PF01974
(tRNA_int_endo)
4 VAL A 228
LEU A 230
ILE A 215
CYH A 214
None
0.80A 4asdA-2ohcA:
undetectable
4asdA-2ohcA:
23.85
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2pid TYROSYL-TRNA
SYNTHETASE


(Homo sapiens)
PF00579
(tRNA-synt_1b)
4 ILE A 251
VAL A 271
LEU A  47
ILE A 269
None
0.90A 4asdA-2pidA:
undetectable
4asdA-2pidA:
23.76
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2q50 GLYOXYLATE
REDUCTASE/HYDROXYPYR
UVATE REDUCTASE


(Homo sapiens)
PF00389
(2-Hacid_dh)
PF02826
(2-Hacid_dh_C)
4 ILE A 168
VAL A 214
CYH A 226
ILE A 241
None
0.75A 4asdA-2q50A:
undetectable
4asdA-2q50A:
23.23
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2q5o PHENYLPYRUVATE
DECARBOXYLASE


(Azospirillum
brasilense)
PF00205
(TPP_enzyme_M)
PF02775
(TPP_enzyme_C)
PF02776
(TPP_enzyme_N)
4 ILE A 376
VAL A 451
LEU A 515
ILE A 452
None
0.92A 4asdA-2q5oA:
undetectable
4asdA-2q5oA:
22.39
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2r5r UPF0343 PROTEIN
NE1163


(Nitrosomonas
europaea)
PF02649
(GCHY-1)
4 ILE A 131
VAL A 176
LEU A 233
ILE A 243
None
0.94A 4asdA-2r5rA:
undetectable
4asdA-2r5rA:
18.36
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2x8x TLR1789 PROTEIN

(Thermosynechococcus
elongatus)
PF07244
(POTRA)
PF08479
(POTRA_2)
4 ILE X 296
VAL X 279
LEU X 281
ILE X 293
None
0.85A 4asdA-2x8xX:
undetectable
4asdA-2x8xX:
21.90
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2xe4 OLIGOPEPTIDASE B

(Leishmania
major)
PF00326
(Peptidase_S9)
PF02897
(Peptidase_S9_N)
4 VAL A 277
LEU A 279
ILE A 267
CYH A 266
None
0.85A 4asdA-2xe4A:
undetectable
4asdA-2xe4A:
19.16
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3a0f XYLOGLUCANASE

(Geotrichum sp.
M128)
no annotation 4 ILE A 439
VAL A   8
ILE A 749
CYH A 750
None
0.86A 4asdA-3a0fA:
undetectable
4asdA-3a0fA:
18.67
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3a76 GAMMA-HEXACHLOROCYCL
OHEXANE
DEHYDROCHLORINASE


(Sphingomonas
paucimobilis)
PF13577
(SnoaL_4)
4 ILE A  72
VAL A  24
LEU A  32
ILE A  22
None
0.79A 4asdA-3a76A:
undetectable
4asdA-3a76A:
21.78
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3a9v 4-COUMARATE--COA
LIGASE


(Populus
tomentosa)
PF00501
(AMP-binding)
PF13193
(AMP-binding_C)
4 ILE A 252
VAL A 272
LEU A 299
ILE A 274
None
0.74A 4asdA-3a9vA:
undetectable
4asdA-3a9vA:
22.83
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3hng VASCULAR ENDOTHELIAL
GROWTH FACTOR
RECEPTOR 1


(Homo sapiens)
PF07714
(Pkinase_Tyr)
6 ILE A 885
VAL A 892
CYH A 912
LEU A1029
ILE A1038
CYH A1039
None
8ST  A2001 ( 4.7A)
8ST  A2001 (-3.8A)
None
None
8ST  A2001 (-4.2A)
0.54A 4asdA-3hngA:
44.3
4asdA-3hngA:
67.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3hps 2-ISOPROPYLMALATE
SYNTHASE


(Mycobacterium
tuberculosis)
PF00682
(HMGL-like)
PF08502
(LeuA_dimer)
4 ILE A 239
VAL A 280
LEU A 282
ILE A 248
None
0.87A 4asdA-3hpsA:
undetectable
4asdA-3hpsA:
18.67
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ibs CONSERVED
HYPOTHETICAL PROTEIN
BATB


(Bacteroides
thetaiotaomicron)
PF00092
(VWA)
4 ILE A 203
VAL A  47
LEU A  60
ILE A  10
None
0.81A 4asdA-3ibsA:
undetectable
4asdA-3ibsA:
19.53
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3nkl UDP-D-QUINOVOSAMINE
4-DEHYDROGENASE


(Aliivibrio
fischeri)
PF02629
(CoA_binding)
4 ILE A  29
VAL A  66
LEU A  68
ILE A   6
None
0.84A 4asdA-3nklA:
undetectable
4asdA-3nklA:
18.36
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3qe3 SORBITOL
DEHYDROGENASE


(Ovis aries)
PF00107
(ADH_zinc_N)
PF08240
(ADH_N)
4 ILE A 306
VAL A  90
LEU A  35
CYH A 138
None
0.91A 4asdA-3qe3A:
undetectable
4asdA-3qe3A:
21.98
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3s29 SUCROSE SYNTHASE 1

(Arabidopsis
thaliana)
PF00534
(Glycos_transf_1)
PF00862
(Sucrose_synth)
4 ILE A  43
VAL A  86
LEU A  88
ILE A  80
None
0.88A 4asdA-3s29A:
undetectable
4asdA-3s29A:
16.97
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3s5c LINA

(uncultured
organism)
no annotation 4 ILE B  72
VAL B  24
LEU B  32
ILE B  22
None
0.88A 4asdA-3s5cB:
undetectable
4asdA-3s5cB:
18.39
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3sth GLYCERALDEHYDE-3-PHO
SPHATE DEHYDROGENASE


(Toxoplasma
gondii)
PF00044
(Gp_dh_N)
PF02800
(Gp_dh_C)
4 ILE A 146
CYH A   3
LEU A   5
ILE A  94
None
0.89A 4asdA-3sthA:
undetectable
4asdA-3sthA:
25.37
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3uyk NDP-RHAMNOSYLTRANSFE
RASE


(Saccharopolyspora
spinosa)
PF06722
(DUF1205)
4 ILE A 349
VAL A 289
ILE A 222
CYH A 221
None
0.86A 4asdA-3uykA:
undetectable
4asdA-3uykA:
22.44
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3vid VASCULAR ENDOTHELIAL
GROWTH FACTOR
RECEPTOR 2


(Homo sapiens)
PF07714
(Pkinase_Tyr)
6 ILE A 892
VAL A 899
CYH A 919
LEU A1035
ILE A1044
CYH A1045
None
None
4TT  A2001 (-4.3A)
4TT  A2001 (-4.8A)
None
None
0.37A 4asdA-3vidA:
39.8
4asdA-3vidA:
85.96
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3wzd VASCULAR ENDOTHELIAL
GROWTH FACTOR
RECEPTOR 2


(Homo sapiens)
PF07714
(Pkinase_Tyr)
6 ILE A 892
VAL A 899
CYH A 919
LEU A1035
ILE A1044
CYH A1045
None
None
LEV  A1201 (-4.1A)
LEV  A1201 (-4.8A)
None
GOL  A1210 ( 3.3A)
0.39A 4asdA-3wzdA:
38.3
4asdA-3wzdA:
100.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4a4i PROTEIN LIN-28
HOMOLOG B


(Homo sapiens)
PF00313
(CSD)
5 ILE A  49
VAL A  83
CYH A 107
LEU A  77
CYH A  34
None
1.44A 4asdA-4a4iA:
undetectable
4asdA-4a4iA:
13.94
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4agd VASCULAR ENDOTHELIAL
GROWTH FACTOR
RECEPTOR 2


(Homo sapiens)
PF07714
(Pkinase_Tyr)
6 ILE A 892
VAL A 899
CYH A 919
LEU A1035
ILE A1044
CYH A1045
None
B49  A2000 ( 4.6A)
B49  A2000 (-4.2A)
B49  A2000 (-4.5A)
None
B49  A2000 ( 4.1A)
0.36A 4asdA-4agdA:
34.3
4asdA-4agdA:
100.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4agu CYCLIN-DEPENDENT
KINASE-LIKE 1


(Homo sapiens)
PF00069
(Pkinase)
4 VAL A  64
CYH A  83
LEU A 133
CYH A 143
None
D15  A 500 (-4.3A)
D15  A 500 (-4.5A)
D15  A 500 ( 4.0A)
0.28A 4asdA-4aguA:
22.5
4asdA-4aguA:
25.43
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4c95 DNA POLYMERASE
ALPHA-BINDING
PROTEIN


(Saccharomyces
cerevisiae)
PF12341
(Mcl1_mid)
4 ILE A 615
VAL A 581
LEU A 545
ILE A 589
None
0.84A 4asdA-4c95A:
undetectable
4asdA-4c95A:
22.04
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ci8 ECHINODERM
MICROTUBULE-ASSOCIAT
ED PROTEIN-LIKE 1


(Homo sapiens)
PF00400
(WD40)
PF03451
(HELP)
4 ILE A 463
VAL A 475
LEU A 469
CYH A 467
None
0.93A 4asdA-4ci8A:
undetectable
4asdA-4ci8A:
19.79
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4cok PYRUVATE
DECARBOXYLASE


(Gluconacetobacter
diazotrophicus)
PF00205
(TPP_enzyme_M)
PF02775
(TPP_enzyme_C)
PF02776
(TPP_enzyme_N)
4 VAL A 304
LEU A 306
ILE A 281
CYH A 282
None
0.91A 4asdA-4cokA:
undetectable
4asdA-4cokA:
20.63
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4cs6 AMINOGLYCOSIDE
ADENYLTRANSFERASE


(Salmonella
enterica)
PF01909
(NTP_transf_2)
PF13427
(DUF4111)
4 ILE A  48
VAL A  38
LEU A   3
ILE A   5
None
0.90A 4asdA-4cs6A:
undetectable
4asdA-4cs6A:
20.49
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4d7a TRNA
THREONYLCARBAMOYLADE
NOSINE DEHYDRATASE


(Escherichia
coli)
PF00899
(ThiF)
4 ILE A  38
CYH A 142
LEU A 149
ILE A 126
None
None
GOL  A 502 (-4.7A)
None
0.87A 4asdA-4d7aA:
undetectable
4asdA-4d7aA:
21.95
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4dgj ENTEROPEPTIDASE
CATALYTIC LIGHT
CHAIN


(Homo sapiens)
PF00089
(Trypsin)
4 ILE A 108
VAL A  16
LEU A  18
ILE A  56
None
0.85A 4asdA-4dgjA:
undetectable
4asdA-4dgjA:
20.11
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4fg8 CALCIUM/CALMODULIN-D
EPENDENT PROTEIN
KINASE TYPE 1


(Homo sapiens)
PF00069
(Pkinase)
4 ILE A  73
VAL A  79
LEU A 148
ILE A 160
None
ATP  A 401 (-4.7A)
ATP  A 401 (-4.6A)
None
0.65A 4asdA-4fg8A:
21.2
4asdA-4fg8A:
26.61
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ghb HYPOTHETICAL PROTEIN

(Bacteroides
uniformis)
PF15283
(DUF4595)
4 ILE A  65
VAL A 285
LEU A 279
ILE A 284
None
0.93A 4asdA-4ghbA:
undetectable
4asdA-4ghbA:
22.07
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4gps KLLA0E02245P

(Kluyveromyces
lactis)
no annotation 4 ILE A 190
CYH A  44
LEU A  42
ILE A 392
None
0.89A 4asdA-4gpsA:
undetectable
4asdA-4gpsA:
24.27
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4h37 LMO2059 PROTEIN

(Listeria
monocytogenes)
PF07885
(Ion_trans_2)
4 ILE A  29
VAL A  24
LEU A  20
ILE A  22
None
0.76A 4asdA-4h37A:
undetectable
4asdA-4h37A:
16.76
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4hv4 UDP-N-ACETYLMURAMATE
--L-ALANINE LIGASE


(Yersinia pestis)
PF01225
(Mur_ligase)
PF02875
(Mur_ligase_C)
PF08245
(Mur_ligase_M)
4 ILE A 247
VAL A 236
ILE A 231
CYH A 230
None
0.92A 4asdA-4hv4A:
undetectable
4asdA-4hv4A:
21.40
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4iao NAD-DEPENDENT
HISTONE DEACETYLASE
SIR2


(Saccharomyces
cerevisiae)
PF02146
(SIR2)
PF04574
(DUF592)
4 ILE A 516
LEU A 260
ILE A 468
CYH A 469
None
0.75A 4asdA-4iaoA:
undetectable
4asdA-4iaoA:
22.60
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4l52 MITOGEN-ACTIVATED
PROTEIN KINASE
KINASE KINASE 7,
TGF-BETA-ACTIVATED
KINASE 1 AND
MAP3K7-BINDING
PROTEIN 1 CHIMERA


(Homo sapiens)
PF07714
(Pkinase_Tyr)
4 VAL A  90
LEU A 163
ILE A 173
CYH A 174
None
1UL  A 501 (-4.3A)
None
1UL  A 501 (-3.6A)
0.29A 4asdA-4l52A:
19.9
4asdA-4l52A:
28.01
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4o38 CYCLIN-G-ASSOCIATED
KINASE


(Homo sapiens)
PF00069
(Pkinase)
4 VAL A  99
CYH A 126
LEU A 180
CYH A 190
None
SIN  A 401 (-4.3A)
SIN  A 401 ( 4.5A)
None
0.52A 4asdA-4o38A:
20.1
4asdA-4o38A:
24.56
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4p1c TOLUENE-4-MONOOXYGEN
ASE SYSTEM PROTEIN A


(Pseudomonas
mendocina)
PF02332
(Phenol_Hydrox)
5 ILE A 170
VAL A 396
LEU A 404
ILE A 402
CYH A 397
None
1.41A 4asdA-4p1cA:
undetectable
4asdA-4p1cA:
19.84
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4pw0 ALPHA/BETA HYDROLASE
FOLD PROTEIN


(Chitinophaga
pinensis)
PF00561
(Abhydrolase_1)
4 ILE A 124
LEU A  63
ILE A  37
CYH A  38
None
0.92A 4asdA-4pw0A:
undetectable
4asdA-4pw0A:
21.53
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4qtb MITOGEN-ACTIVATED
PROTEIN KINASE 3


(Homo sapiens)
PF00069
(Pkinase)
4 ILE A  91
LEU A 173
ILE A 182
CYH A 183
None
38Z  A 418 (-4.4A)
None
38Z  A 418 ( 3.8A)
0.81A 4asdA-4qtbA:
21.1
4asdA-4qtbA:
26.45
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4r72 ABC-TYPE FE3+
TRANSPORT SYSTEM,
PERIPLASMIC
COMPONENT


(Actinobacillus
pleuropneumoniae)
PF13343
(SBP_bac_6)
4 ILE A 155
VAL A 312
LEU A 317
ILE A 315
None
0.89A 4asdA-4r72A:
undetectable
4asdA-4r72A:
18.08
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4rhe 3-OCTAPRENYL-4-HYDRO
XYBENZOATE
CARBOXY-LYASE


(Colwellia
psychrerythraea)
PF02441
(Flavoprotein)
4 ILE A 122
LEU A  25
ILE A  13
CYH A 103
None
0.89A 4asdA-4rheA:
undetectable
4asdA-4rheA:
20.23
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4rt7 RECEPTOR-TYPE
TYROSINE-PROTEIN
KINASE FLT3


(Homo sapiens)
PF07714
(Pkinase_Tyr)
5 VAL A 675
CYH A 694
LEU A 818
ILE A 827
CYH A 828
None
None
P30  A1001 (-4.6A)
P30  A1001 ( 4.8A)
P30  A1001 (-4.1A)
0.36A 4asdA-4rt7A:
32.2
4asdA-4rt7A:
43.33
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4w7s PRE-MRNA-SPLICING
ATP-DEPENDENT RNA
HELICASE PRP28


(Saccharomyces
cerevisiae)
PF00270
(DEAD)
PF00271
(Helicase_C)
4 ILE A 443
VAL A 510
LEU A 508
ILE A 440
None
0.91A 4asdA-4w7sA:
undetectable
4asdA-4w7sA:
21.38
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4wsq AP2-ASSOCIATED
PROTEIN KINASE 1


(Homo sapiens)
PF00069
(Pkinase)
4 VAL A 104
CYH A 129
LEU A 183
CYH A 193
None
KSA  A 405 (-4.5A)
KSA  A 405 (-4.6A)
KSA  A 405 (-3.4A)
0.51A 4asdA-4wsqA:
22.6
4asdA-4wsqA:
24.38
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4xgj UNCHARACTERIZED
PROTEIN


(Pectobacterium
atrosepticum)
PF07005
(DUF1537)
PF17042
(DUF1357_C)
4 ILE A  91
VAL A  14
LEU A  12
ILE A  88
None
0.86A 4asdA-4xgjA:
undetectable
4asdA-4xgjA:
22.46
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4xr7 PAB-DEPENDENT
POLY(A)-SPECIFIC
RIBONUCLEASE SUBUNIT
PAN3


(Saccharomyces
cerevisiae)
no annotation 4 ILE L 349
VAL L 412
LEU L 409
ILE L 423
None
0.92A 4asdA-4xr7L:
12.9
4asdA-4xr7L:
18.75
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4xrl MITOGEN-ACTIVATED
PROTEIN KINASE 1


(Rattus
norvegicus)
PF00069
(Pkinase)
4 ILE A  72
LEU A 154
ILE A 163
CYH A 164
None
42A  A 402 ( 4.9A)
None
None
0.87A 4asdA-4xrlA:
20.9
4asdA-4xrlA:
25.71
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4xuf RECEPTOR-TYPE
TYROSINE-PROTEIN
KINASE FLT3


(Homo sapiens)
PF07714
(Pkinase_Tyr)
5 VAL A 675
CYH A 694
LEU A 818
ILE A 827
CYH A 828
None
P30  A1001 (-4.2A)
P30  A1001 (-4.3A)
P30  A1001 (-4.7A)
P30  A1001 (-4.8A)
0.24A 4asdA-4xufA:
39.0
4asdA-4xufA:
51.75
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4zdk CTP SYNTHASE

(Mycobacterium
tuberculosis)
PF00117
(GATase)
PF06418
(CTP_synth_N)
4 ILE A 488
LEU A 394
ILE A 399
CYH A 398
None
ONL  A 601 ( 4.1A)
None
None
0.79A 4asdA-4zdkA:
undetectable
4asdA-4zdkA:
20.50
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5b04 PROBABLE TRANSLATION
INITIATION FACTOR
EIF-2B SUBUNIT DELTA


(Schizosaccharomyces
pombe)
PF01008
(IF-2B)
5 ILE G 332
VAL G 298
CYH G 310
LEU G 314
CYH G 321
None
1.49A 4asdA-5b04G:
3.1
4asdA-5b04G:
21.21
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ci6 MITOGEN-ACTIVATED
PROTEIN KINASE 6


(Arabidopsis
thaliana)
PF00069
(Pkinase)
4 VAL A 123
LEU A 196
ILE A 205
CYH A 206
None
0.28A 4asdA-5ci6A:
20.2
4asdA-5ci6A:
24.94
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ci7 SERINE/THREONINE-PRO
TEIN KINASE ULK1


(Homo sapiens)
PF00069
(Pkinase)
4 VAL A  76
CYH A  95
LEU A 145
ILE A 163
None
51W  A 401 (-3.9A)
51W  A 401 (-4.5A)
None
0.42A 4asdA-5ci7A:
23.3
4asdA-5ci7A:
26.50
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5cyp SEPTIN-9

(Homo sapiens)
PF00735
(Septin)
4 ILE A 273
VAL A 162
LEU A 158
CYH A 136
None
0.91A 4asdA-5cypA:
undetectable
4asdA-5cypA:
23.90
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5dl2 REGULATOR OF
PROTEASE B (ROPB)


(Streptococcus
pyogenes)
no annotation 4 VAL A 250
LEU A 272
ILE A 252
CYH A 249
None
0.86A 4asdA-5dl2A:
undetectable
4asdA-5dl2A:
22.32
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5eaw DNA REPLICATION
ATP-DEPENDENT
HELICASE/NUCLEASE
DNA2


(Mus musculus)
PF08696
(Dna2)
PF13086
(AAA_11)
PF13087
(AAA_12)
5 ILE A 647
VAL A 762
CYH A 744
ILE A 761
CYH A 760
None
1.34A 4asdA-5eawA:
2.9
4asdA-5eawA:
16.86
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5eus PRESTIN,RAT PRESTIN
STAS DOMAIN


(Rattus
norvegicus)
PF01740
(STAS)
4 ILE A 639
VAL A 674
LEU A 676
ILE A 643
None
0.80A 4asdA-5eusA:
undetectable
4asdA-5eusA:
15.25
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5grn PLATELET-DERIVED
GROWTH FACTOR
RECEPTOR ALPHA


(Homo sapiens)
PF07714
(Pkinase_Tyr)
5 VAL A 658
CYH A 677
LEU A 825
ILE A 834
CYH A 835
748  A1001 ( 4.8A)
748  A1001 (-4.5A)
748  A1001 (-4.3A)
748  A1001 (-4.8A)
748  A1001 (-4.5A)
0.27A 4asdA-5grnA:
42.2
4asdA-5grnA:
48.40
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5i3o BMP-2-INDUCIBLE
PROTEIN KINASE


(Homo sapiens)
PF00069
(Pkinase)
4 VAL A 109
CYH A 133
LEU A 187
CYH A 197
None
IDV  A 401 (-4.6A)
IDV  A 401 (-4.4A)
IDV  A 401 (-3.6A)
0.40A 4asdA-5i3oA:
4.9
4asdA-5i3oA:
22.77
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5irr SEPTIN-LIKE PROTEIN

(Chlamydomonas
reinhardtii)
PF00735
(Septin)
4 ILE A 376
VAL A 255
LEU A 251
CYH A 231
None
0.84A 4asdA-5irrA:
undetectable
4asdA-5irrA:
20.60
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5j46 PEPTIDE DEFORMYLASE

(Burkholderia
multivorans)
PF01327
(Pep_deformylase)
4 VAL A 144
LEU A 141
ILE A 146
CYH A 145
None
0.84A 4asdA-5j46A:
undetectable
4asdA-5j46A:
19.61
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5j4g UNCHARACTERIZED
PROTEIN


(Helicobacter
pylori)
no annotation 4 ILE A  57
VAL A  91
ILE A  31
CYH A  32
None
0.94A 4asdA-5j4gA:
undetectable
4asdA-5j4gA:
15.32
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5jxr CHROMATIN-REMODELING
COMPLEX ATPASE-LIKE
PROTEIN


(Thermothelomyces
thermophila)
PF00176
(SNF2_N)
PF00271
(Helicase_C)
4 ILE A 312
LEU A 266
ILE A 290
CYH A 289
None
0.87A 4asdA-5jxrA:
undetectable
4asdA-5jxrA:
17.26
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5m0y CELLULOSOME
ANCHORING PROTEIN
COHESIN REGION
IG DOMAIN PROTEIN
GROUP 2 DOMAIN
PROTEIN


(Ruminiclostridium
thermocellum)
PF00963
(Cohesin)
no annotation
4 ILE A  95
VAL B 153
LEU B 139
ILE B 150
None
0.89A 4asdA-5m0yA:
undetectable
4asdA-5m0yA:
18.96
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5mj7 UNCHARACTERIZED
PROTEIN


(Caenorhabditis
elegans)
PF01156
(IU_nuc_hydro)
4 ILE A  64
VAL A   9
LEU A 130
ILE A  10
None
0.93A 4asdA-5mj7A:
undetectable
4asdA-5mj7A:
24.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5o0y SERINE/THREONINE-PRO
TEIN KINASE
TOUSLED-LIKE 2


(Homo sapiens)
no annotation 4 VAL A 527
CYH A 547
LEU A 599
ILE A 611
None
AGS  A 801 (-4.3A)
None
None
0.87A 4asdA-5o0yA:
20.3
4asdA-5o0yA:
13.66
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5oy0 PHOTOSYSTEM I P700
CHLOROPHYLL A
APOPROTEIN A1


(Synechocystis
sp. PCC 6803)
no annotation 4 VAL 1 443
LEU 1 440
ILE 1 445
CYH 1 444
CLA  1 838 (-4.9A)
CLA  1 838 (-3.5A)
CLA  1 832 (-4.1A)
None
0.93A 4asdA-5oy01:
undetectable
4asdA-5oy01:
14.06
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ux5 BIFUNCTIONAL PROTEIN
PROLINE UTILIZATION
A (PUTA)


(Corynebacterium
freiburgense)
PF00171
(Aldedh)
PF01619
(Pro_dh)
4 ILE A 875
VAL A 729
LEU A 731
ILE A 697
None
0.90A 4asdA-5ux5A:
undetectable
4asdA-5ux5A:
15.84
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5v2m MEVALONATE
DIPHOSPHATE
DECARBOXYLASE


(Enterococcus
faecalis)
no annotation 4 ILE A 235
VAL A 289
LEU A 299
CYH A 277
None
0.79A 4asdA-5v2mA:
undetectable
4asdA-5v2mA:
22.05
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5xfm ALPHA-GLUCOSIDASE

(Bacteroides
thetaiotaomicron)
no annotation 4 VAL A 609
LEU A 611
ILE A 646
CYH A 645
None
0.83A 4asdA-5xfmA:
undetectable
4asdA-5xfmA:
14.98
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5xxu RIBOSOMAL PROTEIN
US2


(Toxoplasma
gondii)
PF00318
(Ribosomal_S2)
4 ILE A 124
VAL A 158
ILE A 160
CYH A 161
None
0.90A 4asdA-5xxuA:
undetectable
4asdA-5xxuA:
20.28
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6d6q EXOSOME COMPLEX
EXONUCLEASE RRP44


(Homo sapiens)
no annotation 4 ILE K 582
VAL K 504
ILE K 563
CYH K 562
None
0.92A 4asdA-6d6qK:
undetectable
4asdA-6d6qK:
15.24
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6fdy -

(-)
no annotation 4 ILE U  69
VAL U  75
CYH U  94
LEU U 144
None
DB8  U 301 (-4.8A)
DB8  U 301 (-4.2A)
DB8  U 301 (-4.8A)
0.75A 4asdA-6fdyU:
20.8
4asdA-6fdyU:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6ft1 FLAVODOXIN

(Bacillus cereus)
no annotation 4 ILE A  33
VAL A  25
LEU A 137
ILE A  22
None
0.92A 4asdA-6ft1A:
undetectable
4asdA-6ft1A:
12.17