SIMILAR PATTERNS OF AMINO ACIDS FOR 4ASD_A_BAXA1500_1

List of similar pattern of amino acids derived from ASSAM search

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click link on the last column to view superposed patterns of amino acids in NGL viewer)
(Note that only 3-12 residue patterns can be used for ASSAM searches)
Filter list by:
Hit Macromolecule/
Organism		 Pfam Res. Interface HETATM RMSD Dali Z-score Seq. Identity (%) View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1cm8 PHOSPHORYLATED MAP
KINASE P38-GAMMA

(Homo sapiens) 		PF00069
(Pkinase) 		7 VAL A  41
ALA A  54
LYS A  56
GLU A  74
LEU A  78
PHE A 111
HIS A 151
 ANP  A 400 (-4.1A)
ANP  A 400 (-3.3A)
ANP  A 400 (-2.9A)
None
None
ANP  A 400 ( 4.3A)
None
 0.59A 4asdA-1cm8A:
20.6		 4asdA-1cm8A:
24.88
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1opk PROTO-ONCOGENE
TYROSINE-PROTEIN
KINASE ABL1

(Mus musculus) 		PF00017
(SH2)
PF00018
(SH3_1)
PF07714
(Pkinase_Tyr) 		9 LEU A 267
VAL A 275
ALA A 288
LYS A 290
GLU A 305
PHE A 336
GLY A 340
LEU A 373
HIS A 380
 P16  A   2 ( 4.2A)
P16  A   2 (-4.5A)
P16  A   2 (-3.4A)
P16  A   2 (-4.5A)
P16  A   2 (-4.2A)
P16  A   2 ( 4.4A)
P16  A   2 (-3.4A)
None
None
 0.62A 4asdA-1opkA:
30.0		 4asdA-1opkA:
28.12
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1q8y SR PROTEIN KINASE

(Saccharomyces
cerevisiae) 		PF00069
(Pkinase) 		8 LEU A 164
VAL A 172
ALA A 185
LYS A 187
GLU A 202
LEU A 206
GLY A 250
HIS A 292
 ADP  A 810 ( 4.3A)
ADP  A 810 (-4.1A)
ADP  A 810 (-3.3A)
ADP  A 810 (-3.1A)
None
None
None
None
 0.89A 4asdA-1q8yA:
20.9		 4asdA-1q8yA:
23.45
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1rjb FL CYTOKINE RECEPTOR

(Homo sapiens) 		PF07714
(Pkinase_Tyr) 		8 LEU A 616
VAL A 624
ALA A 642
LYS A 644
GLU A 661
GLY A 697
LEU A 802
HIS A 809
 None
 0.53A 4asdA-1rjbA:
40.6		 4asdA-1rjbA:
47.80
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1t46 HOMO SAPIENS V-KIT
HARDY-ZUCKERMAN 4
FELINE SARCOMA VIRAL
ONCOGENE HOMOLOG

(Homo sapiens) 		PF07714
(Pkinase_Tyr) 		10 LEU A 595
VAL A 603
ALA A 621
LYS A 623
GLU A 640
LEU A 644
GLY A 676
LEU A 783
HIS A 790
PHE A 811
 STI  A   3 ( 3.8A)
STI  A   3 ( 4.6A)
STI  A   3 (-3.5A)
STI  A   3 (-3.7A)
STI  A   3 (-3.6A)
STI  A   3 (-4.4A)
STI  A   3 ( 3.8A)
None
STI  A   3 (-4.5A)
STI  A   3 (-3.6A)
 0.70A 4asdA-1t46A:
32.9		 4asdA-1t46A:
49.44
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1u59 TYROSINE-PROTEIN
KINASE ZAP-70

(Homo sapiens) 		PF07714
(Pkinase_Tyr) 		7 LEU A 344
VAL A 352
ALA A 367
GLU A 386
GLY A 420
LEU A 452
HIS A 459
 STU  A 100 (-3.8A)
STU  A 100 (-4.8A)
STU  A 100 (-3.2A)
None
STU  A 100 (-3.5A)
None
None
 0.58A 4asdA-1u59A:
31.1		 4asdA-1u59A:
30.34
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1u5q SERINE/THREONINE
PROTEIN KINASE TAO2

(Rattus
norvegicus) 		PF00069
(Pkinase) 		8 VAL A  42
ALA A  55
LYS A  57
GLU A  76
LEU A  80
GLY A 110
LEU A 142
HIS A 149
 None
 0.66A 4asdA-1u5qA:
23.3		 4asdA-1u5qA:
27.97
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1zlt SERINE/THREONINE-PRO
TEIN KINASE CHK1

(Homo sapiens) 		PF00069
(Pkinase) 		8 LEU A  15
VAL A  23
ALA A  36
LYS A  38
GLU A  55
GLY A  90
LEU A 121
HIS A 128
 HYM  A 400 (-4.2A)
HYM  A 400 (-4.3A)
HYM  A 400 (-3.5A)
HYM  A 400 (-3.2A)
None
None
None
None
 0.56A 4asdA-1zltA:
20.6		 4asdA-1zltA:
23.90
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1zws DAP-KINASE RELATED
PROTEIN 1

(Homo sapiens) 		PF00069
(Pkinase) 		8 LEU A  19
VAL A  27
ALA A  40
LYS A  42
GLU A  64
LEU A  68
LEU A 130
HIS A 137
 None
 0.78A 4asdA-1zwsA:
21.9		 4asdA-1zwsA:
25.55
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2a2a DEATH-ASSOCIATED
PROTEIN KINASE 2

(Homo sapiens) 		PF00069
(Pkinase) 		8 LEU A  19
VAL A  27
ALA A  40
LYS A  42
GLU A  64
LEU A  68
LEU A 130
HIS A 137
 None
None
GOL  A3001 (-3.5A)
None
None
None
None
None
 0.55A 4asdA-2a2aA:
22.3		 4asdA-2a2aA:
25.96
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2a2a DEATH-ASSOCIATED
PROTEIN KINASE 2

(Homo sapiens) 		PF00069
(Pkinase) 		8 LEU A  19
VAL A  27
LYS A  42
GLU A  64
LEU A  68
GLY A  99
LEU A 130
HIS A 137
 None
 0.76A 4asdA-2a2aA:
22.3		 4asdA-2a2aA:
25.96
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2buj SERINE/THREONINE-PRO
TEIN KINASE 16

(Homo sapiens) 		PF00069
(Pkinase) 		8 LEU A  26
VAL A  34
ALA A  47
LYS A  49
GLU A  65
PHE A 100
GLY A 104
HIS A 146
 STU  A1301 (-4.2A)
STU  A1301 (-4.8A)
STU  A1301 (-3.6A)
STU  A1301 ( 4.0A)
None
STU  A1301 (-4.5A)
STU  A1301 ( 4.0A)
None
 0.75A 4asdA-2bujA:
22.6		 4asdA-2bujA:
27.42
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2dq7 PROTO-ONCOGENE
TYROSINE-PROTEIN
KINASE FYN

(Homo sapiens) 		PF07714
(Pkinase_Tyr) 		7 LEU X  17
VAL X  25
ALA X  37
LYS X  39
GLU X  54
GLY X  88
HIS X 128
 STU  X 902 (-3.8A)
STU  X 902 ( 4.8A)
STU  X 902 (-3.1A)
STU  X 902 (-3.1A)
STU  X 902 ( 4.4A)
STU  X 902 (-3.5A)
None
 0.60A 4asdA-2dq7X:
30.8		 4asdA-2dq7X:
32.93
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2eu9 DUAL SPECIFICITY
PROTEIN KINASE CLK3

(Homo sapiens) 		PF00069
(Pkinase) 		7 LEU A 162
VAL A 170
ALA A 184
LYS A 186
GLU A 201
LEU A 205
HIS A 281
 None
 0.55A 4asdA-2eu9A:
21.9		 4asdA-2eu9A:
22.66
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2gcd SERINE/THREONINE-PRO
TEIN KINASE TAO2

(Rattus
norvegicus) 		PF00069
(Pkinase) 		7 VAL A  42
ALA A  55
GLU A  76
LEU A  80
GLY A 110
LEU A 142
HIS A 149
 STU  A 400 ( 4.8A)
STU  A 400 (-3.2A)
None
None
STU  A 400 (-3.4A)
None
None
 0.58A 4asdA-2gcdA:
24.1		 4asdA-2gcdA:
26.89
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2hk5 TYROSINE-PROTEIN
KINASE HCK

(Homo sapiens) 		PF07714
(Pkinase_Tyr) 		8 LEU A 251
VAL A 259
ALA A 271
LYS A 273
GLU A 288
PHE A 318
GLY A 322
HIS A 362
 1BM  A 499 ( 3.7A)
1BM  A 499 ( 4.8A)
1BM  A 499 (-3.6A)
1BM  A 499 (-3.8A)
1BM  A 499 (-3.2A)
1BM  A 499 (-4.1A)
1BM  A 499 (-3.5A)
None
 0.98A 4asdA-2hk5A:
30.3		 4asdA-2hk5A:
35.61
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2hw6 MAP
KINASE-INTERACTING
SERINE/THREONINE-PRO
TEIN KINASE 1

(Homo sapiens) 		PF00069
(Pkinase) 		8 LEU A  55
VAL A  63
ALA A  76
LYS A  78
LEU A  98
GLY A 130
LEU A 161
HIS A 168
 None
 0.77A 4asdA-2hw6A:
20.7		 4asdA-2hw6A:
24.94
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2hz0 PROTO-ONCOGENE
TYROSINE-PROTEIN
KINASE ABL1

(Homo sapiens) 		PF07714
(Pkinase_Tyr) 		10 LEU A 248
VAL A 256
ALA A 269
LYS A 271
GLU A 286
PHE A 317
GLY A 321
LEU A 354
HIS A 361
PHE A 382
 GIN  A 600 ( 4.6A)
GIN  A 600 ( 4.7A)
GIN  A 600 (-3.1A)
GIN  A 600 (-3.6A)
GIN  A 600 (-3.6A)
GIN  A 600 (-4.3A)
None
GIN  A 600 ( 4.6A)
GIN  A 600 (-4.3A)
GIN  A 600 (-4.0A)
 0.69A 4asdA-2hz0A:
31.8		 4asdA-2hz0A:
35.55
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2ogv MACROPHAGE
COLONY-STIMULATING
FACTOR 1 RECEPTOR
PRECURSOR

(Homo sapiens) 		PF07714
(Pkinase_Tyr) 		8 LEU A 588
VAL A 596
ALA A 614
LYS A 616
GLU A 633
GLY A 669
LEU A 769
HIS A 776
 None
 0.63A 4asdA-2ogvA:
39.9		 4asdA-2ogvA:
48.31
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2ogv MACROPHAGE
COLONY-STIMULATING
FACTOR 1 RECEPTOR
PRECURSOR

(Homo sapiens) 		PF07714
(Pkinase_Tyr) 		8 VAL A 596
ALA A 614
LYS A 616
GLU A 633
GLY A 669
LEU A 769
HIS A 776
PHE A 797
 None
 0.84A 4asdA-2ogvA:
39.9		 4asdA-2ogvA:
48.31
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2phk PHOSPHORYLASE KINASE

(Oryctolagus
cuniculus) 		PF00069
(Pkinase) 		8 LEU A  25
VAL A  33
ALA A  46
LYS A  48
GLU A  73
LEU A  77
GLY A 109
HIS A 147
 ATP  A 381 ( 4.3A)
ATP  A 381 (-4.1A)
ATP  A 381 (-3.5A)
ATP  A 381 (-3.2A)
None
None
None
None
 0.69A 4asdA-2phkA:
21.9		 4asdA-2phkA:
23.56
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2psq FIBROBLAST GROWTH
FACTOR RECEPTOR 2

(Homo sapiens) 		PF07714
(Pkinase_Tyr) 		8 LEU A 487
VAL A 495
ALA A 515
GLU A 534
VAL A 564
GLY A 570
LEU A 617
HIS A 624
 None
 0.69A 4asdA-2psqA:
26.3		 4asdA-2psqA:
50.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2qlu ACTIVIN RECEPTOR
TYPE IIB

(Homo sapiens) 		PF00069
(Pkinase) 		8 VAL A 204
ALA A 215
LYS A 217
GLU A 230
PHE A 267
GLY A 271
LEU A 301
HIS A 319
 ADE  A 488 ( 4.9A)
ADE  A 488 (-3.2A)
None
None
ADE  A 488 (-4.3A)
ADE  A 488 ( 4.1A)
None
None
 0.89A 4asdA-2qluA:
24.3		 4asdA-2qluA:
23.96
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2w4k DEATH-ASSOCIATED
PROTEIN KINASE 1

(Homo sapiens) 		PF00069
(Pkinase) 		9 LEU A  19
VAL A  27
ALA A  40
LYS A  42
GLU A  64
LEU A  68
GLY A  99
LEU A 130
HIS A 137
 ADP  A1303 ( 3.9A)
ADP  A1303 (-4.0A)
ADP  A1303 (-3.5A)
ADP  A1303 (-2.7A)
ADP  A1303 ( 4.8A)
None
None
None
None
 0.76A 4asdA-2w4kA:
16.4		 4asdA-2w4kA:
25.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2xik SERINE/THREONINE
PROTEIN KINASE 25

(Homo sapiens) 		PF00069
(Pkinase) 		7 VAL A  34
ALA A  47
GLU A  66
LEU A  70
GLY A 101
LEU A 131
HIS A 138
 J60  A1294 ( 4.9A)
J60  A1294 (-3.3A)
None
None
J60  A1294 ( 3.8A)
None
None
 0.56A 4asdA-2xikA:
23.6		 4asdA-2xikA:
27.08
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2yab DEATH-ASSOCIATED
PROTEIN KINASE 2

(Mus musculus) 		PF00069
(Pkinase) 		9 LEU A  19
VAL A  27
ALA A  40
LYS A  42
GLU A  64
LEU A  68
GLY A  99
LEU A 130
HIS A 137
 AMP  A1302 (-3.7A)
AMP  A1302 (-4.2A)
AMP  A1302 (-3.6A)
AMP  A1302 (-2.8A)
None
None
None
None
None
 0.72A 4asdA-2yabA:
5.7		 4asdA-2yabA:
25.67
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2z7r RIBOSOMAL PROTEIN S6
KINASE ALPHA-1

(Homo sapiens) 		PF00069
(Pkinase) 		7 LEU A  68
VAL A  76
ALA A  92
LYS A  94
PHE A 143
GLY A 147
LEU A 178
 STU  A   1 (-3.8A)
None
STU  A   1 (-3.3A)
STU  A   1 (-2.8A)
STU  A   1 (-4.6A)
STU  A   1 ( 3.9A)
None
 0.42A 4asdA-2z7rA:
21.5		 4asdA-2z7rA:
27.82
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3b2t FIBROBLAST GROWTH
FACTOR RECEPTOR 2

(Homo sapiens) 		PF07714
(Pkinase_Tyr) 		7 LEU A 487
VAL A 495
ALA A 515
VAL A 564
GLY A 570
LEU A 617
HIS A 624
 M33  A1996 (-4.0A)
M33  A1996 ( 4.7A)
M33  A1996 (-3.3A)
None
M33  A1996 ( 4.8A)
None
None
 0.53A 4asdA-3b2tA:
34.1		 4asdA-3b2tA:
49.01
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3bqr DEATH-ASSOCIATED
PROTEIN KINASE 3

(Homo sapiens) 		PF00069
(Pkinase) 		9 LEU A  19
VAL A  27
ALA A  40
LYS A  42
GLU A  64
LEU A  68
GLY A  99
LEU A 130
HIS A 137
 4RB  A 401 ( 3.9A)
4RB  A 401 ( 4.4A)
4RB  A 401 (-3.3A)
4RB  A 401 ( 2.8A)
GOL  A 503 (-2.8A)
None
None
None
None
 0.82A 4asdA-3bqrA:
20.0		 4asdA-3bqrA:
25.88
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3c4f BASIC FIBROBLAST
GROWTH FACTOR
RECEPTOR 1

(Homo sapiens) 		PF07714
(Pkinase_Tyr) 		8 LEU A 484
ALA A 512
GLU A 531
VAL A 561
GLY A 567
LEU A 614
HIS A 621
PHE A 489
 C4F  A   1 ( 3.9A)
C4F  A   1 (-3.3A)
None
C4F  A   1 ( 4.8A)
None
None
None
C4F  A   1 (-3.7A)
 0.80A 4asdA-3c4fA:
25.6		 4asdA-3c4fA:
54.78
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3c4f BASIC FIBROBLAST
GROWTH FACTOR
RECEPTOR 1

(Homo sapiens) 		PF07714
(Pkinase_Tyr) 		8 LEU A 484
VAL A 492
ALA A 512
GLU A 531
VAL A 561
GLY A 567
LEU A 614
HIS A 621
 C4F  A   1 ( 3.9A)
None
C4F  A   1 (-3.3A)
None
C4F  A   1 ( 4.8A)
None
None
None
 0.64A 4asdA-3c4fA:
25.6		 4asdA-3c4fA:
54.78
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3hng VASCULAR ENDOTHELIAL
GROWTH FACTOR
RECEPTOR 1

(Homo sapiens) 		PF07714
(Pkinase_Tyr) 		11 LEU A 833
VAL A 841
ALA A 859
LYS A 861
GLU A 878
LEU A 882
VAL A 909
GLY A 915
LEU A1013
HIS A1020
PHE A1041
 8ST  A2001 ( 4.7A)
8ST  A2001 ( 4.6A)
8ST  A2001 ( 3.8A)
8ST  A2001 (-4.0A)
8ST  A2001 (-3.7A)
None
8ST  A2001 (-4.1A)
None
8ST  A2001 (-4.6A)
8ST  A2001 ( 4.8A)
8ST  A2001 ( 3.7A)
 0.49A 4asdA-3hngA:
44.3		 4asdA-3hngA:
67.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3lj0 SERINE/THREONINE-PRO
TEIN
KINASE/ENDORIBONUCLE
ASE IRE1

(Saccharomyces
cerevisiae) 		PF00069
(Pkinase)
PF06479
(Ribonuc_2-5A) 		8 LEU A 680
VAL A 689
ALA A 700
LYS A 702
GLU A 715
LEU A 719
LEU A 788
HIS A 795
 ADP  A2101 ( 4.1A)
ADP  A2101 (-4.5A)
ADP  A2101 (-3.5A)
ADP  A2101 (-2.7A)
None
None
None
None
 0.78A 4asdA-3lj0A:
21.9		 4asdA-3lj0A:
22.47
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3lm5 SERINE/THREONINE-PRO
TEIN KINASE 17B

(Homo sapiens) 		PF00069
(Pkinase) 		8 LEU A  39
VAL A  47
ALA A  60
GLU A  80
LEU A  84
GLY A 116
LEU A 149
HIS A 156
 QUE  A   1 ( 3.8A)
QUE  A   1 ( 4.6A)
QUE  A   1 (-3.2A)
QUE  A   1 (-3.1A)
QUE  A   1 ( 4.6A)
None
None
None
 0.77A 4asdA-3lm5A:
23.6		 4asdA-3lm5A:
25.32
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3mvj CAMP-DEPENDENT
PROTEIN KINASE
CATALYTIC SUBUNIT
ALPHA

(Homo sapiens) 		PF00069
(Pkinase) 		7 LEU A  49
VAL A  57
ALA A  70
LYS A  72
GLU A  91
LEU A  95
GLY A 126
 XFE  A 351 (-4.2A)
XFE  A 351 ( 4.5A)
XFE  A 351 (-3.2A)
None
None
None
None
 0.51A 4asdA-3mvjA:
21.0		 4asdA-3mvjA:
25.06
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3nuu PKB-LIKE

(Homo sapiens) 		PF00069
(Pkinase) 		8 LEU A  88
VAL A  96
ALA A 109
LYS A 111
GLU A 130
GLY A 165
LEU A 196
HIS A 203
 JOZ  A 361 (-4.1A)
JOZ  A 361 ( 4.7A)
JOZ  A 361 (-3.4A)
SO4  A   5 (-2.8A)
SO4  A   5 (-3.1A)
None
None
None
 0.66A 4asdA-3nuuA:
22.9		 4asdA-3nuuA:
25.21
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3nyo G PROTEIN-COUPLED
RECEPTOR KINASE 6

(Homo sapiens) 		PF00069
(Pkinase)
PF00615
(RGS) 		8 LEU A 192
VAL A 200
ALA A 213
LYS A 215
GLU A 234
LEU A 238
GLY A 269
LEU A 302
 AMP  A 577 ( 4.3A)
AMP  A 577 (-4.3A)
AMP  A 577 (-3.4A)
AMP  A 577 (-2.8A)
None
None
None
None
 0.65A 4asdA-3nyoA:
21.2		 4asdA-3nyoA:
22.03
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3q5i PROTEIN KINASE

(Plasmodium
berghei) 		PF00069
(Pkinase)
PF13499
(EF-hand_7) 		10 LEU A  63
VAL A  71
ALA A  84
LYS A  86
GLU A 115
LEU A 119
PHE A 146
GLY A 150
LEU A 181
HIS A 188
 ANP  A1634 ( 4.3A)
ANP  A1634 (-4.1A)
ANP  A1634 (-3.6A)
ANP  A1634 (-3.1A)
None
None
ANP  A1634 (-4.8A)
None
None
None
 0.72A 4asdA-3q5iA:
19.9		 4asdA-3q5iA:
22.57
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3she MAP KINASE-ACTIVATED
PROTEIN KINASE 3

(Homo sapiens) 		PF00069
(Pkinase) 		8 LEU A  50
VAL A  58
ALA A  71
LYS A  73
GLU A  84
GLY A 124
LEU A 157
HIS A 164
 I85  A 350 (-3.7A)
I85  A 350 (-4.9A)
I85  A 350 (-3.3A)
I85  A 350 (-2.8A)
None
I85  A 350 (-3.0A)
None
None
 0.85A 4asdA-3sheA:
18.3		 4asdA-3sheA:
22.28
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3tt0 BASIC FIBROBLAST
GROWTH FACTOR
RECEPTOR 1

(Homo sapiens) 		PF07714
(Pkinase_Tyr) 		9 LEU A 484
VAL A 492
ALA A 512
LYS A 514
GLU A 531
VAL A 561
GLY A 567
LEU A 614
HIS A 621
 07J  A   1 ( 4.3A)
07J  A   1 (-4.0A)
07J  A   1 (-3.5A)
07J  A   1 (-4.5A)
07J  A   1 (-3.8A)
07J  A   1 (-4.7A)
07J  A   1 (-3.7A)
None
None
 0.66A 4asdA-3tt0A:
34.6		 4asdA-3tt0A:
50.26
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3txo PROTEIN KINASE C ETA
TYPE

(Homo sapiens) 		PF00069
(Pkinase)
PF00433
(Pkinase_C) 		9 LEU A 361
VAL A 369
ALA A 382
LYS A 384
GLU A 403
LEU A 407
PHE A 435
GLY A 439
LEU A 470
 07U  A   1 ( 4.8A)
07U  A   1 (-4.8A)
07U  A   1 (-3.3A)
07U  A   1 (-3.0A)
07U  A   1 ( 4.8A)
None
None
None
None
 0.80A 4asdA-3txoA:
13.6		 4asdA-3txoA:
23.89
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3vid VASCULAR ENDOTHELIAL
GROWTH FACTOR
RECEPTOR 2

(Homo sapiens) 		PF07714
(Pkinase_Tyr) 		10 LEU A 840
VAL A 848
ALA A 866
GLU A 885
LEU A 889
VAL A 916
PHE A 918
GLY A 922
LEU A1019
HIS A1026
 4TT  A2001 ( 4.0A)
4TT  A2001 ( 4.5A)
4TT  A2001 (-3.5A)
None
None
None
4TT  A2001 (-4.5A)
4TT  A2001 (-3.7A)
None
None
 0.43A 4asdA-3vidA:
39.8		 4asdA-3vidA:
85.96
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3vid VASCULAR ENDOTHELIAL
GROWTH FACTOR
RECEPTOR 2

(Homo sapiens) 		PF07714
(Pkinase_Tyr) 		9 LEU A 840
VAL A 848
ALA A 866
LYS A 868
GLU A 885
LEU A 889
VAL A 916
PHE A 918
GLY A 922
 4TT  A2001 ( 4.0A)
4TT  A2001 ( 4.5A)
4TT  A2001 (-3.5A)
None
None
None
None
4TT  A2001 (-4.5A)
4TT  A2001 (-3.7A)
 0.57A 4asdA-3vidA:
39.8		 4asdA-3vidA:
85.96
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3wzd VASCULAR ENDOTHELIAL
GROWTH FACTOR
RECEPTOR 2

(Homo sapiens) 		PF07714
(Pkinase_Tyr) 		10 LEU A 840
VAL A 848
ALA A 866
GLU A 885
LEU A 889
VAL A 916
PHE A 918
GLY A 922
LEU A1019
HIS A1026
 LEV  A1201 ( 3.8A)
LEV  A1201 ( 4.9A)
LEV  A1201 (-3.5A)
LEV  A1201 (-3.7A)
LEV  A1201 ( 4.4A)
LEV  A1201 ( 4.6A)
LEV  A1201 (-4.7A)
LEV  A1201 (-3.6A)
None
None
 0.58A 4asdA-3wzdA:
38.3		 4asdA-3wzdA:
100.00
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3wzd VASCULAR ENDOTHELIAL
GROWTH FACTOR
RECEPTOR 2

(Homo sapiens) 		PF07714
(Pkinase_Tyr) 		9 LEU A 840
VAL A 848
ALA A 866
LYS A 868
GLU A 885
LEU A 889
VAL A 916
PHE A 918
GLY A 922
 LEV  A1201 ( 3.8A)
LEV  A1201 ( 4.9A)
LEV  A1201 (-3.5A)
None
LEV  A1201 (-3.7A)
LEV  A1201 ( 4.4A)
LEV  A1201 ( 4.6A)
LEV  A1201 (-4.7A)
LEV  A1201 (-3.6A)
 0.66A 4asdA-3wzdA:
38.3		 4asdA-3wzdA:
100.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3zdu CYCLIN-DEPENDENT
KINASE-LIKE 3

(Homo sapiens) 		PF00069
(Pkinase) 		8 VAL A  18
ALA A  31
LYS A  33
GLU A  50
LEU A  54
PHE A  81
LEU A 116
HIS A 123
 38R  A 350 ( 4.8A)
38R  A 350 (-3.4A)
38R  A 350 (-2.9A)
38R  A 350 ( 4.8A)
None
38R  A 350 (-4.2A)
None
None
 0.79A 4asdA-3zduA:
7.2		 4asdA-3zduA:
27.57
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3zfx EPHRIN TYPE-B
RECEPTOR 1

(Homo sapiens) 		PF07714
(Pkinase_Tyr) 		8 VAL A 633
ALA A 649
LYS A 651
GLU A 668
PHE A 699
GLY A 703
LEU A 735
HIS A 742
 None
 0.98A 4asdA-3zfxA:
31.9		 4asdA-3zfxA:
30.71
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4agd VASCULAR ENDOTHELIAL
GROWTH FACTOR
RECEPTOR 2

(Homo sapiens) 		PF07714
(Pkinase_Tyr) 		11 LEU A 840
VAL A 848
ALA A 866
GLU A 885
LEU A 889
VAL A 916
PHE A 918
GLY A 922
LEU A1019
HIS A1026
PHE A1047
 B49  A2000 (-3.7A)
None
B49  A2000 (-3.5A)
None
None
B49  A2000 (-4.8A)
B49  A2000 (-4.4A)
B49  A2000 ( 3.7A)
None
None
B49  A2000 (-4.0A)
 0.59A 4asdA-4agdA:
34.3		 4asdA-4agdA:
100.00
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4agd VASCULAR ENDOTHELIAL
GROWTH FACTOR
RECEPTOR 2

(Homo sapiens) 		PF07714
(Pkinase_Tyr) 		10 VAL A 848
ALA A 866
LYS A 868
GLU A 885
LEU A 889
VAL A 916
GLY A 922
LEU A1019
HIS A1026
PHE A1047
 None
B49  A2000 (-3.5A)
B49  A2000 (-3.0A)
None
None
B49  A2000 (-4.8A)
B49  A2000 ( 3.7A)
None
None
B49  A2000 (-4.0A)
 0.77A 4asdA-4agdA:
34.3		 4asdA-4agdA:
100.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4bc6 SERINE/THREONINE-PRO
TEIN KINASE 10

(Homo sapiens) 		PF00069
(Pkinase) 		8 LEU A  42
VAL A  50
ALA A  63
GLU A  81
LEU A  85
PHE A 112
GLY A 116
HIS A 155
 XZN  A1317 (-3.6A)
XZN  A1317 ( 4.7A)
XZN  A1317 (-3.5A)
XZN  A1317 (-3.9A)
None
XZN  A1317 (-4.5A)
XZN  A1317 ( 3.7A)
None
 0.79A 4asdA-4bc6A:
20.6		 4asdA-4bc6A:
25.33
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4c0t LIKELY PROTEIN
KINASE

(Candida
albicans) 		PF00069
(Pkinase) 		8 LEU A 246
VAL A 254
ALA A 267
LYS A 269
GLU A 288
LEU A 292
GLY A 324
HIS A 362
 None
 0.71A 4asdA-4c0tA:
22.3		 4asdA-4c0tA:
16.94
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4eut SERINE/THREONINE-PRO
TEIN KINASE TBK1

(Homo sapiens) 		PF00069
(Pkinase) 		10 LEU A  15
VAL A  23
ALA A  36
LYS A  38
GLU A  55
LEU A  59
PHE A  88
GLY A  92
LEU A 126
HIS A 133
 BX7  A 401 (-3.7A)
BX7  A 401 (-4.4A)
BX7  A 401 (-3.4A)
BX7  A 401 ( 4.0A)
None
None
BX7  A 401 ( 4.6A)
BX7  A 401 (-3.5A)
None
None
 0.68A 4asdA-4eutA:
19.4		 4asdA-4eutA:
22.09
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4euu SERINE/THREONINE-PRO
TEIN KINASE TBK1

(Homo sapiens) 		PF00069
(Pkinase) 		10 LEU A  15
VAL A  23
ALA A  36
LYS A  38
GLU A  55
LEU A  59
PHE A  88
GLY A  92
LEU A 126
HIS A 133
 BX7  A 401 (-3.9A)
BX7  A 401 ( 4.6A)
BX7  A 401 (-3.4A)
BX7  A 401 (-3.5A)
None
None
BX7  A 401 ( 4.6A)
BX7  A 401 (-3.3A)
None
None
 0.61A 4asdA-4euuA:
21.8		 4asdA-4euuA:
24.74
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4feq TYROSINE-PROTEIN
KINASE RECEPTOR
TYRO3

(Mus musculus) 		PF07714
(Pkinase_Tyr) 		8 LEU A 514
VAL A 522
ALA A 538
LYS A 540
PHE A 595
GLY A 599
LEU A 636
HIS A 643
 0T8  A 901 (-3.6A)
0T8  A 901 ( 4.4A)
0T8  A 901 (-3.2A)
0T8  A 901 (-3.5A)
0T8  A 901 (-3.9A)
0T8  A 901 ( 3.8A)
None
None
 0.75A 4asdA-4feqA:
22.4		 4asdA-4feqA:
34.99
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4gl9 TYROSINE-PROTEIN
KINASE

(Mus musculus) 		PF07714
(Pkinase_Tyr) 		8 LEU A 855
VAL A 863
ALA A 880
LYS A 882
GLU A 898
GLY A 935
LEU A 967
HIS A 974
 IZA  A2001 (-3.7A)
None
IZA  A2001 (-3.4A)
IZA  A2001 ( 4.7A)
None
IZA  A2001 (-3.3A)
None
None
 0.85A 4asdA-4gl9A:
28.2		 4asdA-4gl9A:
30.48
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4gv1 RAC-ALPHA
SERINE/THREONINE-PRO
TEIN KINASE

(Homo sapiens) 		PF00069
(Pkinase)
PF00433
(Pkinase_C) 		7 LEU A 156
VAL A 164
ALA A 177
LYS A 179
GLU A 198
LEU A 202
GLY A 233
 0XZ  A 501 ( 4.1A)
0XZ  A 501 (-4.5A)
0XZ  A 501 (-3.3A)
GOL  A 503 ( 2.8A)
GOL  A 503 (-3.6A)
None
None
 0.58A 4asdA-4gv1A:
20.8		 4asdA-4gv1A:
23.20
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4hvi TYROSINE-PROTEIN
KINASE JAK3

(Homo sapiens) 		PF07714
(Pkinase_Tyr) 		9 LEU A 828
VAL A 836
ALA A 853
LYS A 855
GLU A 871
LEU A 875
GLY A 908
LEU A 940
HIS A 947
 19S  A1201 (-3.9A)
19S  A1201 (-4.4A)
19S  A1201 (-3.3A)
19S  A1201 (-3.5A)
None
None
19S  A1201 ( 3.8A)
None
None
 0.78A 4asdA-4hviA:
30.0		 4asdA-4hviA:
31.32
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4idt MITOGEN-ACTIVATED
PROTEIN KINASE
KINASE KINASE 14

(Homo sapiens) 		PF00069
(Pkinase) 		8 LEU A 406
VAL A 414
ALA A 427
LYS A 429
GLU A 440
GLY A 475
LEU A 506
HIS A 513
 T28  A 701 (-3.8A)
T28  A 701 (-4.7A)
T28  A 701 (-3.0A)
T28  A 701 ( 3.8A)
None
T28  A 701 ( 3.0A)
None
None
 0.84A 4asdA-4idtA:
21.6		 4asdA-4idtA:
26.84
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4jlc SERINE/THREONINE-PRO
TEIN KINASE TBK1

(Mus musculus) 		PF00069
(Pkinase) 		8 LEU A  15
VAL A  23
ALA A  36
LYS A  38
PHE A  88
GLY A  92
LEU A 126
HIS A 133
 SU6  A 701 (-3.6A)
None
SU6  A 701 (-3.4A)
None
SU6  A 701 (-4.0A)
SU6  A 701 (-3.8A)
None
None
 0.68A 4asdA-4jlcA:
18.1		 4asdA-4jlcA:
20.61
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4k33 FIBROBLAST GROWTH
FACTOR RECEPTOR 3

(Homo sapiens) 		PF07714
(Pkinase_Tyr) 		9 LEU A 478
VAL A 486
ALA A 506
LYS A 508
GLU A 525
VAL A 555
GLY A 561
LEU A 608
HIS A 615
 ACP  A 801 (-3.8A)
ACP  A 801 (-4.2A)
ACP  A 801 (-3.3A)
ACP  A 801 (-2.7A)
ACP  A 801 ( 4.8A)
ACP  A 801 (-4.7A)
ACP  A 801 ( 4.6A)
None
None
 0.81A 4asdA-4k33A:
34.9		 4asdA-4k33A:
51.55
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4l52 MITOGEN-ACTIVATED
PROTEIN KINASE
KINASE KINASE 7,
TGF-BETA-ACTIVATED
KINASE 1 AND
MAP3K7-BINDING
PROTEIN 1 CHIMERA

(Homo sapiens) 		PF07714
(Pkinase_Tyr) 		8 VAL A  50
ALA A  61
LYS A  63
GLU A  77
LEU A  81
GLY A 110
LEU A 144
HIS A 154
 1UL  A 501 ( 4.9A)
1UL  A 501 (-3.1A)
None
None
None
1UL  A 501 ( 3.7A)
None
None
 0.76A 4asdA-4l52A:
19.9		 4asdA-4l52A:
28.01
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4oli NON-RECEPTOR
TYROSINE-PROTEIN
KINASE TYK2

(Homo sapiens) 		PF07714
(Pkinase_Tyr) 		8 LEU A 903
VAL A 911
ALA A 928
GLU A 947
LEU A 951
GLY A 984
LEU A1014
HIS A1021
 2TT  A1202 (-3.5A)
2TT  A1202 (-4.5A)
2TT  A1202 ( 3.9A)
None
None
2TT  A1202 (-3.4A)
None
None
 0.95A 4asdA-4oliA:
27.5		 4asdA-4oliA:
24.92
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4rt7 RECEPTOR-TYPE
TYROSINE-PROTEIN
KINASE FLT3

(Homo sapiens) 		PF07714
(Pkinase_Tyr) 		9 LEU A 616
VAL A 624
ALA A 642
LYS A 644
GLU A 661
GLY A 697
LEU A 802
HIS A 809
PHE A 830
 P30  A1001 (-3.8A)
None
P30  A1001 (-3.4A)
P30  A1001 (-3.4A)
P30  A1001 (-3.6A)
P30  A1001 (-3.4A)
None
P30  A1001 ( 4.3A)
P30  A1001 (-3.9A)
 0.38A 4asdA-4rt7A:
32.2		 4asdA-4rt7A:
43.33
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4tnb G PROTEIN-COUPLED
RECEPTOR KINASE 5

(Homo sapiens) 		PF00069
(Pkinase)
PF00615
(RGS) 		7 LEU A 192
VAL A 200
ALA A 213
LYS A 215
GLU A 234
LEU A 238
LEU A 302
 SGV  A 601 (-4.1A)
SGV  A 601 ( 4.6A)
SGV  A 601 (-3.3A)
SGV  A 601 ( 4.2A)
None
None
None
 0.61A 4asdA-4tnbA:
20.1		 4asdA-4tnbA:
21.84
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4wbo RHODOPSIN KINASE

(Bos taurus) 		PF00069
(Pkinase)
PF00615
(RGS) 		8 LEU A 193
VAL A 201
ALA A 214
LYS A 216
GLU A 235
LEU A 239
GLY A 270
LEU A 305
 ANW  A 601 ( 4.0A)
None
ANW  A 601 (-3.4A)
None
None
None
ANW  A 601 ( 4.5A)
None
 0.91A 4asdA-4wboA:
22.2		 4asdA-4wboA:
21.21
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4wsq AP2-ASSOCIATED
PROTEIN KINASE 1

(Homo sapiens) 		PF00069
(Pkinase) 		8 LEU A  52
VAL A  60
ALA A  72
GLU A  90
PHE A 128
GLY A 132
LEU A 165
HIS A 174
 KSA  A 405 ( 4.0A)
KSA  A 405 ( 4.9A)
KSA  A 405 (-3.2A)
None
KSA  A 405 (-4.8A)
KSA  A 405 (-3.5A)
None
None
 0.80A 4asdA-4wsqA:
22.6		 4asdA-4wsqA:
24.38
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4xcu FIBROBLAST GROWTH
FACTOR RECEPTOR 4

(Homo sapiens) 		PF07714
(Pkinase_Tyr) 		8 LEU A 473
VAL A 481
ALA A 501
GLU A 520
VAL A 550
GLY A 556
LEU A 603
HIS A 610
 40M  A1002 ( 4.6A)
40M  A1002 ( 4.5A)
40M  A1002 ( 4.1A)
40M  A1002 (-3.7A)
40M  A1002 (-4.7A)
40M  A1002 ( 3.7A)
None
None
 0.61A 4asdA-4xcuA:
33.8		 4asdA-4xcuA:
47.04
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4xuf RECEPTOR-TYPE
TYROSINE-PROTEIN
KINASE FLT3

(Homo sapiens) 		PF07714
(Pkinase_Tyr) 		8 LEU A 616
VAL A 624
ALA A 642
GLU A 661
GLY A 697
LEU A 802
HIS A 809
PHE A 830
 P30  A1001 (-4.0A)
P30  A1001 ( 4.8A)
P30  A1001 (-3.5A)
P30  A1001 (-3.1A)
P30  A1001 (-3.5A)
None
P30  A1001 (-4.4A)
P30  A1001 ( 4.1A)
 0.57A 4asdA-4xufA:
39.0		 4asdA-4xufA:
51.75
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4xuf RECEPTOR-TYPE
TYROSINE-PROTEIN
KINASE FLT3

(Homo sapiens) 		PF07714
(Pkinase_Tyr) 		8 LEU A 616
VAL A 624
ALA A 642
LYS A 644
GLU A 661
GLY A 697
HIS A 809
PHE A 830
 P30  A1001 (-4.0A)
P30  A1001 ( 4.8A)
P30  A1001 (-3.5A)
P30  A1001 ( 4.0A)
P30  A1001 (-3.1A)
P30  A1001 (-3.5A)
P30  A1001 (-4.4A)
P30  A1001 ( 4.1A)
 0.69A 4asdA-4xufA:
39.0		 4asdA-4xufA:
51.75
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4yff SERINE/THREONINE-PRO
TEIN KINASE TNNI3K

(Homo sapiens) 		PF07714
(Pkinase_Tyr) 		8 VAL A 477
ALA A 488
LYS A 490
GLU A 509
LEU A 513
GLY A 545
LEU A 577
HIS A 586
 None
4CV  A 801 (-3.5A)
4CV  A 801 (-3.9A)
None
None
4CV  A 801 ( 4.0A)
None
None
 0.76A 4asdA-4yffA:
25.0		 4asdA-4yffA:
29.01
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4yhj G PROTEIN-COUPLED
RECEPTOR KINASE 4

(Homo sapiens) 		PF00069
(Pkinase)
PF00615
(RGS) 		8 LEU A 193
VAL A 201
ALA A 214
LYS A 216
GLU A 235
LEU A 239
GLY A 270
LEU A 303
 AN2  A 601 ( 4.2A)
AN2  A 601 (-4.0A)
AN2  A 601 (-3.6A)
AN2  A 601 ( 3.9A)
None
None
None
None
 0.97A 4asdA-4yhjA:
20.3		 4asdA-4yhjA:
21.67
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ysj CALMODULIN-LIKE
DOMAIN PROTEIN
KINASE

(Eimeria tenella) 		PF00069
(Pkinase)
PF13499
(EF-hand_7) 		8 LEU A  34
VAL A  42
ALA A  55
LYS A  57
GLU A  76
LEU A  80
GLY A 111
HIS A 149
 ADP  A 506 ( 3.8A)
ADP  A 506 (-4.3A)
ADP  A 506 (-3.3A)
ADP  A 506 (-2.4A)
None
None
None
None
 0.58A 4asdA-4ysjA:
22.2		 4asdA-4ysjA:
23.28
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4z7g SERINE/THREONINE-PRO
TEIN
KINASE/ENDORIBONUCLE
ASE IRE1

(Homo sapiens) 		PF00069
(Pkinase)
PF06479
(Ribonuc_2-5A) 		8 LEU A 577
VAL A 586
ALA A 597
LYS A 599
GLU A 612
LEU A 616
LEU A 679
HIS A 686
 None
 1.00A 4asdA-4z7gA:
20.0		 4asdA-4z7gA:
22.70
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5a46 FIBROBLAST GROWTH
FACTOR RECEPTOR 1
(FMS-RELATED
TYROSINE KINASE 2,
PFEIFFER SYNDROME),
ISOFORM CRA_B

(Homo sapiens) 		PF07714
(Pkinase_Tyr) 		9 LEU A 484
VAL A 492
ALA A 512
LYS A 514
GLU A 531
VAL A 561
GLY A 567
LEU A 614
HIS A 621
 38O  A1769 (-3.2A)
38O  A1769 (-4.5A)
38O  A1769 (-3.6A)
38O  A1769 ( 3.1A)
EDO  A1766 (-4.1A)
38O  A1769 (-4.3A)
38O  A1769 (-3.4A)
None
None
 0.54A 4asdA-5a46A:
25.8		 4asdA-5a46A:
45.43
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5d7a TRAF2 AND
NCK-INTERACTING
PROTEIN KINASE

(Homo sapiens) 		PF00069
(Pkinase) 		9 VAL A  39
ALA A  52
LYS A  54
GLU A  69
LEU A  73
PHE A 107
GLY A 111
LEU A 144
HIS A 151
 VAL  A  39 (-0.6A)
ALA  A  52 (-0.0A)
LYS  A  54 ( 0.0A)
GLU  A  69 ( 0.6A)
LEU  A  73 ( 0.6A)
PHE  A 107 ( 1.3A)
GLY  A 111 (-0.0A)
LEU  A 144 ( 0.6A)
HIS  A 151 ( 1.0A)
 0.79A 4asdA-5d7aA:
10.1		 4asdA-5d7aA:
26.26
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5e8y TGF-BETA RECEPTOR
TYPE-2

(Homo sapiens) 		PF07714
(Pkinase_Tyr) 		8 VAL A 258
ALA A 275
LYS A 277
GLU A 290
PHE A 327
GLY A 331
LEU A 361
HIS A 377
 STU  A 601 (-4.0A)
STU  A 601 (-3.1A)
STU  A 601 (-2.4A)
STU  A 601 ( 3.8A)
STU  A 601 (-3.4A)
STU  A 601 (-3.5A)
None
None
 0.75A 4asdA-5e8yA:
24.3		 4asdA-5e8yA:
27.55
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5f1z NON-RECEPTOR
TYROSINE-PROTEIN
KINASE TYK2

(Homo sapiens) 		PF07714
(Pkinase_Tyr) 		8 LEU A 903
VAL A 911
ALA A 928
LYS A 930
GLU A 947
GLY A 984
LEU A1014
HIS A1021
 5U3  A1200 (-3.8A)
5U3  A1200 ( 4.4A)
5U3  A1200 (-3.5A)
None
None
5U3  A1200 (-3.2A)
None
None
 0.81A 4asdA-5f1zA:
28.3		 4asdA-5f1zA:
28.84
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5f1z NON-RECEPTOR
TYROSINE-PROTEIN
KINASE TYK2

(Homo sapiens) 		PF07714
(Pkinase_Tyr) 		8 LEU A 903
VAL A 911
ALA A 928
LYS A 930
GLU A 947
LEU A 951
GLY A 984
LEU A1014
 5U3  A1200 (-3.8A)
5U3  A1200 ( 4.4A)
5U3  A1200 (-3.5A)
None
None
None
5U3  A1200 (-3.2A)
None
 0.91A 4asdA-5f1zA:
28.3		 4asdA-5f1zA:
28.84
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5fm2 PROTO-ONCOGENE
TYROSINE-PROTEIN
KINASE RECEPTOR RET

(Homo sapiens) 		PF07714
(Pkinase_Tyr) 		8 LEU A 730
VAL A 738
ALA A 756
GLU A 775
LEU A 779
VAL A 804
LEU A 865
HIS A 872
 PP1  A2012 (-4.6A)
PP1  A2012 (-4.4A)
PP1  A2012 (-3.2A)
PP1  A2012 (-3.5A)
None
PP1  A2012 (-4.5A)
None
None
 0.99A 4asdA-5fm2A:
32.5		 4asdA-5fm2A:
41.29
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5fm2 PROTO-ONCOGENE
TYROSINE-PROTEIN
KINASE RECEPTOR RET

(Homo sapiens) 		PF07714
(Pkinase_Tyr) 		8 LEU A 730
VAL A 738
ALA A 756
LEU A 779
VAL A 804
GLY A 810
LEU A 865
HIS A 872
 PP1  A2012 (-4.6A)
PP1  A2012 (-4.4A)
PP1  A2012 (-3.2A)
None
PP1  A2012 (-4.5A)
PTR  A 809 (-2.4A)
None
None
 0.81A 4asdA-5fm2A:
32.5		 4asdA-5fm2A:
41.29
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5fm2 PROTO-ONCOGENE
TYROSINE-PROTEIN
KINASE RECEPTOR RET

(Homo sapiens) 		PF07714
(Pkinase_Tyr) 		8 LEU A 730
VAL A 738
ALA A 756
LYS A 758
GLU A 775
LEU A 779
VAL A 804
HIS A 872
 PP1  A2012 (-4.6A)
PP1  A2012 (-4.4A)
PP1  A2012 (-3.2A)
PP1  A2012 (-4.1A)
PP1  A2012 (-3.5A)
None
PP1  A2012 (-4.5A)
None
 0.96A 4asdA-5fm2A:
32.5		 4asdA-5fm2A:
41.29
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5fm2 PROTO-ONCOGENE
TYROSINE-PROTEIN
KINASE RECEPTOR RET

(Homo sapiens) 		PF07714
(Pkinase_Tyr) 		8 LEU A 730
VAL A 738
ALA A 756
LYS A 758
LEU A 779
VAL A 804
GLY A 810
HIS A 872
 PP1  A2012 (-4.6A)
PP1  A2012 (-4.4A)
PP1  A2012 (-3.2A)
PP1  A2012 (-4.1A)
None
PP1  A2012 (-4.5A)
PTR  A 809 (-2.4A)
None
 0.78A 4asdA-5fm2A:
32.5		 4asdA-5fm2A:
41.29
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5grn PLATELET-DERIVED
GROWTH FACTOR
RECEPTOR ALPHA

(Homo sapiens) 		PF07714
(Pkinase_Tyr) 		9 LEU A 599
VAL A 607
ALA A 625
LYS A 627
GLU A 644
GLY A 680
LEU A 809
HIS A 816
PHE A 837
 748  A1001 (-3.8A)
748  A1001 ( 4.7A)
748  A1001 (-3.7A)
748  A1001 (-4.0A)
748  A1001 (-3.3A)
748  A1001 ( 4.0A)
748  A1001 ( 4.6A)
748  A1001 (-3.8A)
748  A1001 (-3.7A)
 0.51A 4asdA-5grnA:
42.2		 4asdA-5grnA:
48.40
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5i3o BMP-2-INDUCIBLE
PROTEIN KINASE

(Homo sapiens) 		PF00069
(Pkinase) 		8 LEU A  57
VAL A  65
ALA A  77
LYS A  79
GLU A  95
GLY A 136
LEU A 169
HIS A 178
 IDV  A 401 (-3.8A)
IDV  A 401 (-4.6A)
IDV  A 401 (-3.6A)
IDV  A 401 ( 4.8A)
None
IDV  A 401 (-3.4A)
None
None
 0.97A 4asdA-5i3oA:
22.3		 4asdA-5i3oA:
22.77
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5j5t MITOGEN-ACTIVATED
PROTEIN KINASE
KINASE KINASE KINASE
3

(Homo sapiens) 		PF00069
(Pkinase) 		8 VAL A  30
ALA A  43
LYS A  45
GLU A  61
PHE A  92
GLY A  96
LEU A 127
HIS A 134
 6G2  A 901 ( 4.9A)
6G2  A 901 (-3.2A)
6G2  A 901 ( 3.9A)
None
6G2  A 901 (-4.1A)
6G2  A 901 (-3.6A)
None
None
 0.64A 4asdA-5j5tA:
20.4		 4asdA-5j5tA:
21.50
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5jzn SERINE/THREONINE-PRO
TEIN KINASE DCLK1

(Homo sapiens) 		PF00069
(Pkinase) 		8 VAL A 404
ALA A 417
LYS A 419
GLU A 436
LEU A 440
GLY A 471
LEU A 502
HIS A 509
 GUI  A 701 (-4.4A)
GUI  A 701 ( 3.9A)
GUI  A 701 (-3.1A)
None
None
GUI  A 701 (-3.6A)
None
None
 0.97A 4asdA-5jznA:
21.8		 4asdA-5jznA:
25.47
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5lpy PROTEIN
BRASSINOSTEROID
INSENSITIVE 1

(Arabidopsis
thaliana) 		PF00069
(Pkinase) 		8 VAL A 897
ALA A 909
LYS A 911
GLU A 927
PHE A 958
GLY A 962
LEU A 997
HIS A1007
 ATP  A1200 ( 4.5A)
ATP  A1200 (-3.5A)
ATP  A1200 (-3.8A)
None
ATP  A1200 ( 4.0A)
ATP  A1200 ( 4.0A)
None
None
 0.84A 4asdA-5lpyA:
22.7		 4asdA-5lpyA:
27.71
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5td2 TYROSINE-PROTEIN
KINASE MER

(Homo sapiens) 		PF07714
(Pkinase_Tyr) 		8 LEU A 593
VAL A 601
ALA A 617
LYS A 619
PHE A 673
GLY A 677
LEU A 714
HIS A 721
 7AE  A1000 ( 3.9A)
7AE  A1000 ( 4.9A)
7AE  A1000 (-3.3A)
7AE  A1000 (-3.1A)
7AE  A1000 (-4.1A)
7AE  A1000 ( 3.7A)
None
None
 0.72A 4asdA-5td2A:
29.0		 4asdA-5td2A:
36.52
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5vef SERINE/THREONINE-PRO
TEIN KINASE PAK 4

(Homo sapiens) 		no annotation 7 VAL A 335
ALA A 348
LYS A 350
GLU A 366
PHE A 397
GLY A 401
HIS A 438
 M77  A 601 (-4.5A)
M77  A 601 ( 3.5A)
M77  A 601 ( 4.7A)
None
M77  A 601 (-4.1A)
M77  A 601 ( 4.8A)
None
 0.58A 4asdA-5vefA:
21.8		 4asdA-5vefA:
26.01
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5vil MITOGEN-ACTIVATED
PROTEIN KINASE
KINASE KINASE 5

(Homo sapiens) 		no annotation 8 LEU A 686
VAL A 694
ALA A 707
LYS A 709
GLU A 725
GLY A 760
LEU A 794
HIS A 801
 9E1  A1001 (-3.7A)
9E1  A1001 ( 4.0A)
9E1  A1001 (-3.5A)
9E1  A1001 (-2.8A)
None
9E1  A1001 (-3.4A)
None
None
 0.57A 4asdA-5vilA:
18.7		 4asdA-5vilA:
12.31
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5xv7 SERINE-ARGININE (SR)
PROTEIN KINASE 1

(Homo sapiens) 		no annotation 8 LEU A  86
VAL A  94
ALA A 107
LYS A 109
GLU A 124
LEU A 128
LEU A 203
HIS A 211
 EMH  A 705 (-3.9A)
EMH  A 705 ( 4.4A)
EMH  A 705 (-3.6A)
EMH  A 705 ( 4.8A)
None
None
None
None
 0.88A 4asdA-5xv7A:
20.8		 4asdA-5xv7A:
11.82
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5xzw SERINE/THREONINE-PRO
TEIN KINASE RAD53

(Saccharomyces
cerevisiae) 		no annotation 8 VAL A 212
ALA A 225
LYS A 227
GLU A 244
LEU A 248
PHE A 275
GLY A 279
HIS A 317
 None
 0.86A 4asdA-5xzwA:
19.1		 4asdA-5xzwA:
22.96
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6c7y TYROSINE-PROTEIN
KINASE JAK1

(Homo sapiens) 		no annotation 10 LEU A 881
VAL A 889
ALA A 906
LYS A 908
GLU A 925
LEU A 929
PHE A 958
GLY A 962
LEU A 994
HIS A1001
 ADP  A1201 ( 4.5A)
ADP  A1201 (-4.3A)
ADP  A1201 (-3.4A)
ADP  A1201 (-2.8A)
None
None
None
ADP  A1201 ( 4.1A)
None
None
 0.85A 4asdA-6c7yA:
27.8		 4asdA-6c7yA:
13.88
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6cmj CALCIUM/CALMODULIN-D
EPENDENT PROTEIN
KINASE KINASE 2

(Homo sapiens) 		no annotation 8 VAL A 179
ALA A 192
LYS A 194
GLU A 236
LEU A 240
GLY A 273
LEU A 303
HIS A 310
 F6J  A 501 (-4.6A)
F6J  A 501 (-3.4A)
F6J  A 501 (-2.9A)
F6J  A 501 ( 4.7A)
None
F6J  A 501 ( 3.7A)
None
None
 0.83A 4asdA-6cmjA:
22.0		 4asdA-6cmjA:
15.59
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6fek PROTO-ONCOGENE
TYROSINE-PROTEIN
KINASE RECEPTOR RET

(Homo sapiens) 		no annotation 8 LEU A 730
VAL A 738
ALA A 756
GLU A 775
LEU A 779
VAL A 804
LEU A 865
HIS A 872
 ADN  A1104 ( 4.0A)
ADN  A1104 (-4.4A)
ADN  A1104 (-3.4A)
None
None
ADN  A1104 ( 4.6A)
None
None
 0.79A 4asdA-6fekA:
31.9		 4asdA-6fekA:
23.72
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6fek PROTO-ONCOGENE
TYROSINE-PROTEIN
KINASE RECEPTOR RET

(Homo sapiens) 		no annotation 8 LEU A 730
VAL A 738
ALA A 756
LEU A 779
VAL A 804
GLY A 810
LEU A 865
HIS A 872
 ADN  A1104 ( 4.0A)
ADN  A1104 (-4.4A)
ADN  A1104 (-3.4A)
None
ADN  A1104 ( 4.6A)
ADN  A1104 ( 3.8A)
None
None
 0.67A 4asdA-6fekA:
31.9		 4asdA-6fekA:
23.72
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6fyl DUAL SPECIFICITY
PROTEIN KINASE CLK2

(Homo sapiens) 		no annotation 9 LEU A 169
VAL A 177
ALA A 191
LYS A 193
GLU A 208
LEU A 212
GLY A 247
LEU A 281
HIS A 288
 3NG  A 501 (-3.9A)
3NG  A 501 ( 4.4A)
3NG  A 501 (-3.3A)
3NG  A 501 (-3.0A)
3NG  A 501 ( 4.9A)
None
None
None
None
 0.87A 4asdA-6fylA:
22.0		 4asdA-6fylA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6fyo DUAL SPECIFICITY
PROTEIN KINASE CLK1

(Homo sapiens) 		no annotation 9 LEU A 167
VAL A 175
ALA A 189
LYS A 191
GLU A 206
LEU A 210
GLY A 245
LEU A 279
HIS A 286
 EAQ  A 501 (-3.9A)
None
EAQ  A 501 (-3.6A)
EAQ  A 501 (-3.2A)
EAQ  A 501 (-3.4A)
None
EAQ  A 501 (-3.9A)
None
None
 1.26A 4asdA-6fyoA:
21.8		 4asdA-6fyoA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6fyv DUAL SPECIFICITY
PROTEIN KINASE CLK4

(Homo sapiens) 		no annotation 8 LEU A 167
VAL A 175
ALA A 189
LYS A 191
GLU A 206
LEU A 210
GLY A 245
HIS A 286
 3NG  A 501 (-3.9A)
3NG  A 501 ( 4.3A)
3NG  A 501 (-3.5A)
3NG  A 501 (-2.7A)
3NG  A 501 ( 4.7A)
None
None
None
 0.91A 4asdA-6fyvA:
21.7		 4asdA-6fyvA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6fyv DUAL SPECIFICITY
PROTEIN KINASE CLK4

(Homo sapiens) 		no annotation 8 LEU A 167
VAL A 175
LYS A 191
GLU A 206
LEU A 210
GLY A 245
LEU A 279
HIS A 286
 3NG  A 501 (-3.9A)
3NG  A 501 ( 4.3A)
3NG  A 501 (-2.7A)
3NG  A 501 ( 4.7A)
None
None
None
None
 1.05A 4asdA-6fyvA:
21.7		 4asdA-6fyvA:
undetectable