SIMILAR PATTERNS OF AMINO ACIDS FOR 4ARC_A_LEUA1001

List of similar pattern of amino acids derived from ASSAM search

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click link on the last column to view superposed patterns of amino acids in NGL viewer)
(Note that only 3-12 residue patterns can be used for ASSAM searches)
Filter list by:
Hit Macromolecule/
Organism		 Pfam Res. Interface HETATM RMSD Dali Z-score Seq. Identity (%) View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1a2v METHYLAMINE OXIDASE

(Ogataea angusta) 		PF01179
(Cu_amine_oxid)
PF02727
(Cu_amine_oxidN2)
PF02728
(Cu_amine_oxidN3) 		4 LEU A 429
ASP A 630
TYR A 305
HIS A 458
 None
None
TPQ  A 405 ( 4.7A)
CU  A   1 (-3.2A)
 0.98A 4arcA-1a2vA:
0.0		 4arcA-1a2vA:
21.36
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1d2f MALY PROTEIN

(Escherichia
coli) 		PF00155
(Aminotran_1_2) 		4 LEU A 288
SER A 234
TYR A 281
HIS A  81
 None
 1.37A 4arcA-1d2fA:
0.3		 4arcA-1d2fA:
20.75
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1dk5 ANNEXIN 24(CA32)

(Capsicum annuum) 		PF00191
(Annexin) 		4 ASP A 189
SER A 188
TYR A 216
HIS A 184
 None
 1.34A 4arcA-1dk5A:
0.0		 4arcA-1dk5A:
17.19
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1kqg FORMATE
DEHYDROGENASE,
NITRATE-INDUCIBLE,
IRON-SULFUR SUBUNIT

(Escherichia
coli) 		PF09163
(Form-deh_trans)
PF12800
(Fer4_4)
PF13247
(Fer4_11) 		4 ASP B  35
SER B  37
TYR B 237
HIS B 229
 None
 1.17A 4arcA-1kqgB:
undetectable		 4arcA-1kqgB:
14.96
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ksi COPPER AMINE OXIDASE

(Pisum sativum) 		PF01179
(Cu_amine_oxid)
PF02727
(Cu_amine_oxidN2)
PF02728
(Cu_amine_oxidN3) 		4 LEU A 411
ASP A 609
TYR A 286
HIS A 444
 None
None
TPQ  A 387 ( 4.5A)
CU  A 650 ( 3.3A)
 0.96A 4arcA-1ksiA:
undetectable		 4arcA-1ksiA:
21.27
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1lrz FACTOR ESSENTIAL FOR
EXPRESSION OF
METHICILLIN
RESISTANCE

(Staphylococcus
aureus) 		PF02388
(FemAB) 		4 TYR A  71
ASP A 108
TYR A 364
HIS A  22
 None
 1.25A 4arcA-1lrzA:
undetectable		 4arcA-1lrzA:
18.35
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1m3d TYPE IV COLLAGEN
NONCOLLAGENOUS
DOMAIN- ALPHA2

(Bos taurus) 		PF01413
(C4) 		4 LEU C  48
ASP C  45
SER C 157
HIS C  10
 None
 1.18A 4arcA-1m3dC:
undetectable		 4arcA-1m3dC:
13.54
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1m3d TYPE IV COLLAGEN
NONCOLLAGENOUS
DOMAIN- ALPHA2

(Bos taurus) 		PF01413
(C4) 		4 LEU C  48
ASP C  45
SER C 157
TYR C   5
 None
 1.30A 4arcA-1m3dC:
undetectable		 4arcA-1m3dC:
13.54
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1obh LEUCYL-TRNA
SYNTHETASE

(Thermus
thermophilus) 		PF00133
(tRNA-synt_1)
PF08264
(Anticodon_1)
PF13603
(tRNA-synt_1_2)
PF14795
(Leucyl-specific) 		5 TYR A  43
ASP A  80
SER A 504
TYR A 535
HIS A 545
 NVA  A1816 ( 3.5A)
NVA  A1816 (-3.9A)
NVA  A1816 ( 4.8A)
None
NVA  A1816 (-3.5A)
 0.30A 4arcA-1obhA:
45.5		 4arcA-1obhA:
45.70
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1odt CEPHALOSPORIN C
DEACETYLASE

(Bacillus
subtilis) 		PF05448
(AXE1) 		4 ASP C 249
SER C 208
TYR C  14
HIS C 283
 None
 1.30A 4arcA-1odtC:
0.1		 4arcA-1odtC:
17.05
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1r8w GLYCEROL DEHYDRATASE

(Clostridium
butyricum) 		PF01228
(Gly_radical)
PF02901
(PFL-like) 		4 SER A 282
TYR A 157
HIS A 446
HIS A 164
 None
 1.38A 4arcA-1r8wA:
2.8		 4arcA-1r8wA:
20.91
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1u61 HYPOTHETICAL PROTEIN

(Bacillus cereus) 		PF00636
(Ribonuclease_3) 		4 LEU A 126
SER A  45
TYR A  20
HIS A  27
 None
 1.27A 4arcA-1u61A:
undetectable		 4arcA-1u61A:
10.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2a7m N-ACYL HOMOSERINE
LACTONE HYDROLASE

(Bacillus
thuringiensis) 		PF00753
(Lactamase_B) 		4 ASP A  50
SER A 103
HIS A 169
HIS A 173
 None
None
ZN  A 252 (-3.3A)
None
 1.37A 4arcA-2a7mA:
undetectable		 4arcA-2a7mA:
14.17
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2anp LEUCYL
AMINOPEPTIDASE

(Vibrio
proteolyticus) 		PF04389
(Peptidase_M28) 		4 LEU A 155
TYR A 148
SER A 228
HIS A 230
 None
 1.02A 4arcA-2anpA:
undetectable		 4arcA-2anpA:
15.03
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2bi3 PHOSPHOSERINE
AMINOTRANSFERASE

(Bacillus
alcalophilus) 		PF00266
(Aminotran_5) 		4 TYR A 158
SER A 103
TYR A 191
HIS A 146
 None
 1.11A 4arcA-2bi3A:
undetectable		 4arcA-2bi3A:
17.91
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2cn3 BETA-1,4-XYLOGLUCAN
HYDROLASE

(Ruminiclostridium
thermocellum) 		PF02012
(BNR) 		4 TYR A 608
ASP A 600
TYR A 692
HIS A 649
 None
 1.34A 4arcA-2cn3A:
undetectable		 4arcA-2cn3A:
21.87
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2e7u GLUTAMATE-1-SEMIALDE
HYDE 2,1-AMINOMUTASE

(Thermus
thermophilus) 		PF00202
(Aminotran_3) 		4 TYR A 325
SER A 405
TYR A  57
HIS A 408
 None
 1.34A 4arcA-2e7uA:
undetectable		 4arcA-2e7uA:
20.55
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2w1k PUTATIVE SORTASE

(Streptococcus
pneumoniae) 		PF04203
(Sortase) 		4 LEU A 132
SER A  59
TYR A 167
HIS A 124
 MES  A1243 (-3.6A)
None
None
None
 1.37A 4arcA-2w1kA:
undetectable		 4arcA-2w1kA:
15.45
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2w1k PUTATIVE SORTASE

(Streptococcus
pneumoniae) 		PF04203
(Sortase) 		4 TYR A 167
SER A 139
TYR A  62
HIS A 124
 None
 1.34A 4arcA-2w1kA:
undetectable		 4arcA-2w1kA:
15.45
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2wsk GLYCOGEN DEBRANCHING
ENZYME

(Escherichia
coli) 		PF00128
(Alpha-amylase)
PF02922
(CBM_48) 		4 LEU A 513
TYR A 154
HIS A 518
HIS A 520
 None
 1.38A 4arcA-2wskA:
1.9		 4arcA-2wskA:
22.44
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2ymz GALECTIN 2

(Gallus gallus) 		PF00337
(Gal-bind_lectin) 		4 LEU A  60
ASP A  63
SER A  40
TYR A 111
 None
 1.19A 4arcA-2ymzA:
undetectable		 4arcA-2ymzA:
8.98
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2z81 TOLL-LIKE RECEPTOR
2, VARIABLE
LYMPHOCYTE RECEPTOR
B

(Eptatretus
burgeri;
Mus musculus) 		PF11921
(DUF3439)
PF13306
(LRR_5)
PF13516
(LRR_6)
PF13855
(LRR_8) 		4 TYR A 128
ASP A 106
SER A 108
TYR A 136
 None
 1.23A 4arcA-2z81A:
undetectable		 4arcA-2z81A:
19.53
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2ztg ALANYL-TRNA
SYNTHETASE

(Archaeoglobus
fulgidus) 		PF01411
(tRNA-synt_2c)
PF07973
(tRNA_SAD) 		4 LEU A 213
TYR A 161
HIS A 151
HIS A 150
 None
 1.30A 4arcA-2ztgA:
1.9		 4arcA-2ztgA:
23.99
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2zzg ALANYL-TRNA
SYNTHETASE

(Pyrococcus
horikoshii) 		PF01411
(tRNA-synt_2c)
PF07973
(tRNA_SAD) 		4 LEU A 214
TYR A 161
HIS A 151
HIS A 150
 None
 1.22A 4arcA-2zzgA:
2.4		 4arcA-2zzgA:
23.32
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3b7c UNCHARACTERIZED
PROTEIN

(Shewanella
oneidensis) 		PF14534
(DUF4440) 		4 LEU A 103
TYR A  29
ASP A 117
SER A 119
 EDO  A 128 ( 4.8A)
EDO  A 128 (-4.9A)
EDO  A 128 (-3.2A)
EDO  A 128 ( 3.7A)
 1.31A 4arcA-3b7cA:
undetectable		 4arcA-3b7cA:
9.69
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3bxz PREPROTEIN
TRANSLOCASE SUBUNIT
SECA

(Escherichia
coli) 		PF07517
(SecA_DEAD) 		4 LEU A 423
SER A 583
TYR A 587
HIS A 555
 None
 1.27A 4arcA-3bxzA:
undetectable		 4arcA-3bxzA:
20.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3dxp PUTATIVE ACYL-COA
DEHYDROGENASE

(Cupriavidus
pinatubonensis) 		PF01636
(APH) 		4 TYR A 173
SER A 216
TYR A 291
HIS A 155
 None
 1.37A 4arcA-3dxpA:
undetectable		 4arcA-3dxpA:
18.37
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3e74 ALLANTOINASE

(Escherichia
coli) 		PF01979
(Amidohydro_1) 		4 ASP A  57
SER A 314
TYR A 406
HIS A 316
 None
 1.29A 4arcA-3e74A:
undetectable		 4arcA-3e74A:
19.82
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3fa3 2,3-DIMETHYLMALATE
LYASE

(Aspergillus
niger) 		PF13714
(PEP_mutase) 		4 LEU A 132
TYR A 138
ASP A 117
SER A 164
 None
 1.20A 4arcA-3fa3A:
undetectable		 4arcA-3fa3A:
17.72
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3fvr ACETYL XYLAN
ESTERASE

(Bacillus
pumilus) 		PF05448
(AXE1) 		4 ASP A 249
SER A 208
TYR A  14
HIS A 283
 None
 1.29A 4arcA-3fvrA:
undetectable		 4arcA-3fvrA:
17.50
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3g8m SERINE
HYDROXYMETHYLTRANSFE
RASE

(Escherichia
coli) 		PF00464
(SHMT) 		4 ASP A 352
SER A 348
TYR A 177
HIS A 123
 None
 1.17A 4arcA-3g8mA:
1.9		 4arcA-3g8mA:
19.05
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3gyc PUTATIVE GLYCOSIDE
HYDROLASE

(Parabacteroides
distasonis) 		PF12876
(Cellulase-like) 		4 TYR A 181
ASP A 183
SER A 237
TYR A 246
 None
 1.16A 4arcA-3gycA:
undetectable		 4arcA-3gycA:
17.12
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3h9c METHIONYL-TRNA
SYNTHETASE

(Escherichia
coli) 		PF09334
(tRNA-synt_1g) 		4 TYR A  94
ASP A  51
HIS A  28
HIS A  24
 None
 1.12A 4arcA-3h9cA:
27.6		 4arcA-3h9cA:
21.06
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3hea ARYLESTERASE

(Pseudomonas
fluorescens) 		PF00561
(Abhydrolase_1) 		4 TYR A  69
ASP A  99
SER A  25
HIS A  26
 None
 1.24A 4arcA-3heaA:
undetectable		 4arcA-3heaA:
15.02
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3hm7 ALLANTOINASE

(Bacillus
halodurans) 		PF01979
(Amidohydro_1) 		4 ASP A  61
SER A 314
TYR A 408
HIS A 316
 None
 1.31A 4arcA-3hm7A:
undetectable		 4arcA-3hm7A:
19.05
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3icj UNCHARACTERIZED
METAL-DEPENDENT
HYDROLASE

(Pyrococcus
furiosus) 		PF07969
(Amidohydro_3) 		4 TYR A 416
ASP A 400
SER A 399
HIS A 395
 None
 1.36A 4arcA-3icjA:
undetectable		 4arcA-3icjA:
19.87
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ihy PHOSPHATIDYLINOSITOL
3-KINASE CATALYTIC
SUBUNIT TYPE 3

(Homo sapiens) 		PF00454
(PI3_PI4_kinase)
PF00613
(PI3Ka) 		4 LEU A 286
TYR A 321
ASP A 283
SER A 282
 None
 1.26A 4arcA-3ihyA:
undetectable		 4arcA-3ihyA:
22.48
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3k7t 6-HYDROXY-L-NICOTINE
OXIDASE

(Paenarthrobacter
nicotinovorans) 		PF01593
(Amino_oxidase) 		4 LEU A 198
TYR A 407
HIS A  64
HIS A 187
 None
FAD  A 434 (-4.3A)
None
None
 1.17A 4arcA-3k7tA:
undetectable		 4arcA-3k7tA:
19.30
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3loy COPPER AMINE OXIDASE

(Ogataea angusta) 		PF01179
(Cu_amine_oxid) 		4 LEU A 410
ASP A 603
TYR A 288
HIS A 438
 None
None
TPQ  A 386 ( 4.3A)
CU  A 635 (-3.2A)
 1.02A 4arcA-3loyA:
undetectable		 4arcA-3loyA:
21.42
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3m1u PUTATIVE
GAMMA-D-GLUTAMYL-L-D
IAMINO ACID
ENDOPEPTIDASE

(Desulfovibrio
vulgaris) 		PF00877
(NLPC_P60)
PF12912
(N_NLPC_P60)
PF12913
(SH3_6)
PF12914
(SH3_7) 		4 TYR A 322
ASP A 332
SER A 334
HIS A 392
 GOL  A   8 ( 4.9A)
GOL  A   1 (-3.1A)
ACT  A  13 (-2.9A)
GOL  A   8 (-4.0A)
 1.26A 4arcA-3m1uA:
undetectable		 4arcA-3m1uA:
20.07
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3mn2 PROBABLE ARAC FAMILY
TRANSCRIPTIONAL
REGULATOR

(Rhodopseudomonas
palustris) 		PF12833
(HTH_18) 		4 ASP A 282
SER A 281
TYR A 308
HIS A 277
 None
 1.34A 4arcA-3mn2A:
undetectable		 4arcA-3mn2A:
8.72
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3npf PUTATIVE
DIPEPTIDYL-PEPTIDASE
VI

(Bacteroides
ovatus) 		PF00877
(NLPC_P60) 		4 TYR A 191
ASP A 202
SER A 204
HIS A 263
 CSA  A 203 ( 4.5A)
GOL  A 329 (-3.3A)
GOL  A 329 (-3.5A)
CSA  A 203 ( 4.1A)
 1.34A 4arcA-3npfA:
undetectable		 4arcA-3npfA:
15.38
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3p94 GDSL-LIKE LIPASE

(Parabacteroides
distasonis) 		PF13472
(Lipase_GDSL_2) 		4 TYR A 181
ASP A 183
SER A 186
HIS A 185
 None
 1.28A 4arcA-3p94A:
undetectable		 4arcA-3p94A:
12.31
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3pbi INVASION PROTEIN

(Mycobacterium
tuberculosis) 		PF00877
(NLPC_P60) 		4 TYR A 127
ASP A 151
SER A 153
HIS A 201
 None
 1.33A 4arcA-3pbiA:
undetectable		 4arcA-3pbiA:
14.02
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3r89 OROTIDINE
5'-PHOSPHATE
DECARBOXYLASE

(Anaerococcus
prevotii) 		PF00215
(OMPdecase) 		4 LEU A 253
TYR A  66
ASP A  22
SER A 249
 None
 1.31A 4arcA-3r89A:
undetectable		 4arcA-3r89A:
15.80
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3shs HOC HEAD OUTER
CAPSID PROTEIN

(Escherichia
virus RB49) 		no annotation 4 LEU A  92
TYR A 128
SER A 171
HIS A 131
 None
 1.34A 4arcA-3shsA:
undetectable		 4arcA-3shsA:
15.53
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ujz METALLOPROTEASE STCE

(Escherichia
coli) 		PF10462
(Peptidase_M66) 		4 LEU A 356
TYR A 418
ASP A 360
TYR A 706
 None
 0.94A 4arcA-3ujzA:
undetectable		 4arcA-3ujzA:
21.87
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ul4 CELLULOSOME-ANCHORIN
G PROTEIN
CELLULOSOME ENZYME,
DOCKERIN TYPE I

(Ruminiclostridium
thermocellum;
Ruminiclostridium
thermocellum) 		PF00963
(Cohesin)
PF00404
(Dockerin_1) 		4 LEU B  26
ASP A  41
SER B  49
TYR B  19
 None
 1.32A 4arcA-3ul4B:
undetectable		 4arcA-3ul4B:
5.80
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3wo9 VARIABLE LYMPHOCYTE
RECEPTOR C

(Lethenteron
camtschaticum) 		PF01462
(LRRNT)
PF13855
(LRR_8) 		4 TYR A  99
ASP A 123
SER A 146
TYR A 142
 None
 1.33A 4arcA-3wo9A:
undetectable		 4arcA-3wo9A:
13.53
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3zhb R-IMINE REDUCTASE

(Streptomyces
kanamyceticus) 		PF03446
(NAD_binding_2) 		4 ASP A 130
SER A 157
TYR A 175
HIS A 180
 None
 1.30A 4arcA-3zhbA:
undetectable		 4arcA-3zhbA:
16.57
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3ziu LEUCYL-TRNA
SYNTHETASE

(Mycoplasma
mobile) 		PF00133
(tRNA-synt_1)
PF08264
(Anticodon_1) 		5 ASP A  84
SER A 324
TYR A 361
HIS A 367
HIS A 371
 LSS  A1638 (-3.7A)
LSS  A1638 ( 3.9A)
None
LSS  A1638 (-3.8A)
LSS  A1638 (-3.7A)
 0.66A 4arcA-3ziuA:
40.5		 4arcA-3ziuA:
31.41
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3ziu LEUCYL-TRNA
SYNTHETASE

(Mycoplasma
mobile) 		PF00133
(tRNA-synt_1)
PF08264
(Anticodon_1) 		5 TYR A  46
ASP A  84
SER A 324
TYR A 361
HIS A 371
 LSS  A1638 (-3.3A)
LSS  A1638 (-3.7A)
LSS  A1638 ( 3.9A)
None
LSS  A1638 (-3.7A)
 0.29A 4arcA-3ziuA:
40.5		 4arcA-3ziuA:
31.41
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4a0h ADENOSYLMETHIONINE-8
-AMINO-7-OXONONANOAT
E AMINOTRANSFERASE

(Arabidopsis
thaliana) 		PF00202
(Aminotran_3)
PF13500
(AAA_26) 		4 ASP A 429
SER A 682
TYR A 426
HIS A 677
 None
 1.35A 4arcA-4a0hA:
undetectable		 4arcA-4a0hA:
23.90
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4arc LEUCINE--TRNA LIGASE

(Escherichia
coli) 		PF00133
(tRNA-synt_1)
PF08264
(Anticodon_1)
PF13603
(tRNA-synt_1_2) 		7 LEU A  41
TYR A  43
ASP A  80
SER A 496
TYR A 527
HIS A 533
HIS A 537
 LEU  A1001 (-4.9A)
LEU  A1001 (-3.5A)
LEU  A1001 (-3.9A)
LEU  A1001 ( 3.7A)
None
LEU  A1001 (-4.2A)
LEU  A1001 (-3.6A)
 0.00A 4arcA-4arcA:
60.8		 4arcA-4arcA:
100.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4be3 ALGINATE LYASE,
FAMILY PL7

(Zobellia
galactanivorans) 		PF08787
(Alginate_lyase2) 		4 LEU A  55
TYR A 299
SER A  96
HIS A 149
 SRT  A 400 ( 4.0A)
None
SRT  A 400 ( 4.0A)
SRT  A 400 (-3.4A)
 1.33A 4arcA-4be3A:
undetectable		 4arcA-4be3A:
16.92
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4bkx HISTONE DEACETYLASE
1

(Homo sapiens) 		PF00850
(Hist_deacetyl) 		4 ASP B  99
SER B 148
HIS B 178
HIS B 141
 None
None
ZN  B 600 (-3.3A)
ACT  B 601 (-3.8A)
 1.29A 4arcA-4bkxB:
undetectable		 4arcA-4bkxB:
20.14
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4dx3 MANDELATE RACEMASE /
MUCONATE LACTONIZING
ENZYME FAMILY
PROTEIN

(Agrobacterium
fabrum) 		PF02746
(MR_MLE_N)
PF13378
(MR_MLE_C) 		4 ASP A 243
SER A 265
TYR A 118
HIS A 318
 None
None
None
SNN  A 319 ( 3.0A)
 1.37A 4arcA-4dx3A:
1.3		 4arcA-4dx3A:
18.59
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4e2z TCAB9

(Micromonospora
chalcea) 		PF08421
(Methyltransf_13)
PF08484
(Methyltransf_14)
PF13489
(Methyltransf_23) 		4 TYR A  76
ASP A  33
SER A  32
HIS A 181
 SAH  A 503 ( 4.4A)
JHZ  A 504 ( 4.4A)
None
SAH  A 503 (-4.4A)
 1.29A 4arcA-4e2zA:
undetectable		 4arcA-4e2zA:
19.39
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4e51 HISTIDINE--TRNA
LIGASE

(Burkholderia
thailandensis) 		PF03129
(HGTP_anticodon)
PF13393
(tRNA-synt_His) 		4 SER A 368
TYR A 337
HIS A 340
HIS A 366
 None
 1.20A 4arcA-4e51A:
undetectable		 4arcA-4e51A:
19.66
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4f92 U5 SMALL NUCLEAR
RIBONUCLEOPROTEIN
200 KDA HELICASE

(Homo sapiens) 		PF00270
(DEAD)
PF00271
(Helicase_C)
PF02889
(Sec63) 		4 LEU B 500
TYR B 675
SER B 652
TYR B 924
 None
 1.33A 4arcA-4f92B:
undetectable		 4arcA-4f92B:
18.97
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4fdy SIMILAR TO
LIPOPROTEIN, NLP/P60
FAMILY

(Staphylococcus
aureus) 		PF00877
(NLPC_P60)
PF13702
(Lysozyme_like) 		4 TYR A 233
ASP A 245
SER A 247
HIS A 300
 None
OCS  A 246 ( 4.2A)
OCS  A 246 ( 3.5A)
OCS  A 246 ( 3.8A)
 1.36A 4arcA-4fdyA:
undetectable		 4arcA-4fdyA:
16.91
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4flm S-FORMYLGLUTATHIONE
HYDROLASE

(Saccharomyces
cerevisiae) 		PF00756
(Esterase) 		4 LEU A  55
TYR A 165
TYR A 180
HIS A 130
 None
 1.36A 4arcA-4flmA:
undetectable		 4arcA-4flmA:
15.84
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4hpe PUTATIVE CELL WALL
HYDROLASE
TN916-LIKE,CTN1-ORF1
7

(Clostridioides
difficile) 		PF00877
(NLPC_P60)
PF13702
(Lysozyme_like) 		4 TYR A 229
ASP A 241
SER A 243
HIS A 296
 OCS  A 242 ( 4.7A)
OCS  A 242 ( 4.1A)
OCS  A 242 ( 3.6A)
OCS  A 242 ( 3.7A)
 1.26A 4arcA-4hpeA:
undetectable		 4arcA-4hpeA:
16.02
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4itx CYSTATHIONINE
BETA-LYASE METC

(Escherichia
coli) 		PF01053
(Cys_Met_Meta_PP) 		4 LEU A 193
TYR A 211
SER A 307
HIS A 267
 None
 1.38A 4arcA-4itxA:
undetectable		 4arcA-4itxA:
18.19
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4j5t MANNOSYL-OLIGOSACCHA
RIDE GLUCOSIDASE

(Saccharomyces
cerevisiae) 		PF03200
(Glyco_hydro_63)
PF16923
(Glyco_hydro_63N) 		4 TYR A 247
ASP A 218
SER A 214
TYR A 256
 None
 1.30A 4arcA-4j5tA:
undetectable		 4arcA-4j5tA:
21.30
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4jrm 3-OXOACYL-[ACYL-CARR
IER-PROTEIN]
SYNTHASE 2

(Vibrio cholerae) 		no annotation 4 TYR D  77
ASP D 234
SER D 195
HIS D  40
 None
 1.38A 4arcA-4jrmD:
undetectable		 4arcA-4jrmD:
19.09
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4nz0 GENOME POLYPROTEIN

(Cardiovirus A) 		PF00680
(RdRP_1) 		4 LEU A 286
TYR A 285
SER A 276
HIS A  57
 None
 1.37A 4arcA-4nz0A:
undetectable		 4arcA-4nz0A:
20.18
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4q9t NUCLEOPORIN NUP133

(Vanderwaltozyma
polyspora) 		PF08801
(Nucleoporin_N) 		4 LEU A 431
TYR A 357
SER A 447
TYR A 398
 None
 1.27A 4arcA-4q9tA:
undetectable		 4arcA-4q9tA:
17.66
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4qhz PUTATIVE GLYCOSYL
HYDROLASE

(Parabacteroides
distasonis) 		PF06439
(DUF1080) 		4 LEU A 151
TYR A 159
SER A 134
HIS A 248
 None
 1.37A 4arcA-4qhzA:
undetectable		 4arcA-4qhzA:
14.07
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4r0k DIPEPTIDYL-PEPTIDASE
VI

(Bacteroides
thetaiotaomicron) 		PF00877
(NLPC_P60) 		4 TYR A 191
ASP A 202
SER A 204
HIS A 263
 CSA  A 203 ( 4.5A)
EDO  A 404 (-2.9A)
EDO  A 404 (-3.1A)
CSA  A 203 ( 4.0A)
 1.32A 4arcA-4r0kA:
undetectable		 4arcA-4r0kA:
16.25
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ruh CYTOSOLIC
NON-SPECIFIC
DIPEPTIDASE

(Homo sapiens) 		PF01546
(Peptidase_M20)
PF07687
(M20_dimer) 		4 LEU A 473
ASP A 475
TYR A 466
HIS A 393
 None
 1.18A 4arcA-4ruhA:
undetectable		 4arcA-4ruhA:
20.93
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4tmc OLD YELLOW ENZYME

(Kluyveromyces
marxianus) 		PF00724
(Oxidored_FMN) 		4 TYR A 358
ASP A 355
SER A 387
TYR A   3
 None
 1.29A 4arcA-4tmcA:
undetectable		 4arcA-4tmcA:
20.21
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4u4e THIOLASE

(Sphaerobacter
thermophilus) 		PF02803
(Thiolase_C) 		4 LEU A 288
ASP A 292
SER A 252
TYR A 143
 None
 1.22A 4arcA-4u4eA:
undetectable		 4arcA-4u4eA:
18.11
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4v06 TRYPTOPHAN
5-HYDROXYLASE 2

(Homo sapiens) 		PF00351
(Biopterin_H) 		4 TYR A 310
SER A 306
HIS A 179
HIS A 304
 None
 1.21A 4arcA-4v06A:
undetectable		 4arcA-4v06A:
17.66
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4v15 D-THREONINE ALDOLASE

(Achromobacter
xylosoxidans) 		PF01168
(Ala_racemase_N)
PF14031
(D-ser_dehydrat) 		4 LEU A 248
TYR A 245
ASP A 239
SER A 235
 None
 1.25A 4arcA-4v15A:
undetectable		 4arcA-4v15A:
18.74
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4zo6 LIN1840 PROTEIN

(Listeria
innocua) 		PF00933
(Glyco_hydro_3)
PF01915
(Glyco_hydro_3_C)
PF14310
(Fn3-like) 		4 ASP A  68
SER A  63
TYR A  96
HIS A 131
 None
 1.23A 4arcA-4zo6A:
undetectable		 4arcA-4zo6A:
22.05
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4zwe DEOXYNUCLEOSIDE
TRIPHOSPHATE
TRIPHOSPHOHYDROLASE
SAMHD1

(Homo sapiens) 		PF01966
(HD) 		4 LEU A 150
TYR A 315
ASP A 319
HIS A 370
 None
DGT  A 701 (-3.6A)
DGT  A 701 (-3.2A)
DGT  A 701 (-4.6A)
 1.30A 4arcA-4zweA:
undetectable		 4arcA-4zweA:
21.55
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5ah5 LEUCINE--TRNA LIGASE

(Agrobacterium
tumefaciens) 		PF00133
(tRNA-synt_1)
PF08264
(Anticodon_1)
PF13603
(tRNA-synt_1_2) 		6 TYR A  41
ASP A  78
SER A 493
TYR A 523
HIS A 529
HIS A 533
 LSS  A1818 (-3.1A)
LSS  A1818 (-3.6A)
LSS  A1818 (-3.6A)
None
LSS  A1818 (-4.0A)
LSS  A1818 (-3.6A)
 0.75A 4arcA-5ah5A:
43.2		 4arcA-5ah5A:
38.53
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5dxx ARTEMISINIC ALDEHYDE
DELTA(11(13))
REDUCTASE

(Artemisia annua) 		PF00724
(Oxidored_FMN) 		4 ASP A 188
SER A 234
HIS A 239
HIS A 183
 None
None
None
FMN  A7401 (-4.5A)
 1.31A 4arcA-5dxxA:
undetectable		 4arcA-5dxxA:
18.09
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5fei DISTAL TUBE PROTEIN

(Bacillus virus
phi29) 		PF16838
(Caud_tail_N) 		4 LEU A 327
ASP A 322
SER A 527
TYR A 535
 None
 1.21A 4arcA-5feiA:
undetectable		 4arcA-5feiA:
20.18
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5gms ESTERASE

(uncultured
bacterium) 		PF07859
(Abhydrolase_3) 		4 TYR A  32
SER A 145
TYR A  73
HIS A 273
 None
 1.36A 4arcA-5gmsA:
undetectable		 4arcA-5gmsA:
17.75
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5gne LEUCINE
AMINOPEPTIDASE

(Legionella
pneumophila) 		PF04389
(Peptidase_M28) 		4 LEU A 264
TYR A 257
SER A 338
HIS A 340
 None
None
ZN  A 402 ( 4.8A)
None
 1.11A 4arcA-5gneA:
undetectable		 4arcA-5gneA:
18.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5gy3 GLUCANASE

(Klebsiella
pneumoniae) 		PF01270
(Glyco_hydro_8) 		4 TYR A 175
ASP A 110
TYR A 316
HIS A  51
 None
 1.19A 4arcA-5gy3A:
undetectable		 4arcA-5gy3A:
17.31
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5hk8 PROBABLE
PHEOPHORBIDASE

(Arabidopsis
thaliana) 		PF12697
(Abhydrolase_6) 		4 LEU A 213
TYR A 163
HIS A  86
HIS A  21
 None
 1.38A 4arcA-5hk8A:
undetectable		 4arcA-5hk8A:
17.48
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5hl3 LMO2470 PROTEIN

(Listeria
monocytogenes) 		PF00560
(LRR_1)
PF12354
(Internalin_N)
PF13855
(LRR_8) 		4 TYR A 288
ASP A 272
SER A 291
TYR A 369
 None
 1.15A 4arcA-5hl3A:
undetectable		 4arcA-5hl3A:
17.10
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5imy VAGINOLYSIN

(Gardnerella
vaginalis) 		PF01289
(Thiol_cytolysin)
PF17440
(Thiol_cytolys_C) 		4 LEU A 206
SER A 199
TYR A 395
HIS A 229
 None
 1.34A 4arcA-5imyA:
undetectable		 4arcA-5imyA:
21.13
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5j68 ASTROTACTIN-2

(Homo sapiens) 		PF01823
(MACPF) 		4 LEU A 979
TYR A 983
SER A 851
HIS A 852
 None
NAG  A1300 ( 4.1A)
None
NAG  A1300 ( 4.3A)
 1.31A 4arcA-5j68A:
undetectable		 4arcA-5j68A:
21.36
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5jbo BETA-GLUCOSIDASE

(Trichoderma
harzianum) 		PF00232
(Glyco_hydro_1) 		4 LEU A 358
SER A 360
TYR A 315
HIS A 413
 None
 1.36A 4arcA-5jboA:
undetectable		 4arcA-5jboA:
20.09
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5jzd ISOCHORISMATE
SYNTHASE ENTC

(Escherichia
coli) 		PF00425
(Chorismate_bind) 		4 LEU A 232
ASP A 238
SER A 215
HIS A 276
 None
None
ISC  A 401 (-2.7A)
ISC  A 401 (-3.5A)
 1.34A 4arcA-5jzdA:
undetectable		 4arcA-5jzdA:
18.58
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5kgn 2,3-BISPHOSPHOGLYCER
ATE-INDEPENDENT
PHOSPHOGLYCERATE
MUTASE

(Caenorhabditis
elegans) 		PF01676
(Metalloenzyme)
PF06415
(iPGM_N) 		4 LEU A 140
ASP A 175
TYR A 283
HIS A 149
 None
 1.09A 4arcA-5kgnA:
undetectable		 4arcA-5kgnA:
20.58
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5lts RNA-DIRECTED RNA
POLYMERASE L

(Lymphocytic
choriomeningitis
mammarenavirus) 		PF17296
(ArenaCapSnatch) 		4 LEU A  21
ASP A  18
HIS A  63
HIS A  61
 None
 0.89A 4arcA-5ltsA:
undetectable		 4arcA-5ltsA:
15.16
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5m59 PRE-MRNA SPLICING
HELICASE-LIKE
PROTEIN

(Chaetomium
thermophilum) 		PF00270
(DEAD)
PF00271
(Helicase_C)
PF02889
(Sec63) 		4 LEU A 548
TYR A 723
SER A 700
TYR A 974
 None
 1.35A 4arcA-5m59A:
undetectable		 4arcA-5m59A:
19.59
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5mih PA-I GALACTOPHILIC
LECTIN

(Pseudomonas
aeruginosa) 		no annotation 4 LEU A  55
TYR A  98
ASP A 100
HIS A  50
 None
None
7NU  A 201 ( 2.5A)
7NU  A 201 (-3.9A)
 1.33A 4arcA-5mihA:
undetectable		 4arcA-5mihA:
8.79
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5t67 SUGAR 3-C-METHYL
TRANSFERASE

(Actinomadura
kijaniata) 		PF08421
(Methyltransf_13)
PF08484
(Methyltransf_14)
PF13489
(Methyltransf_23) 		4 TYR A  76
ASP A  33
SER A  32
TYR A  47
 SAH  A 502 (-4.4A)
JHZ  A 503 ( 4.3A)
None
None
 1.32A 4arcA-5t67A:
undetectable		 4arcA-5t67A:
19.98
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5t81 EPOB

(Sorangium
cellulosum) 		PF00668
(Condensation) 		4 LEU A 459
TYR A 453
TYR A 482
HIS A 450
 None
 1.31A 4arcA-5t81A:
undetectable		 4arcA-5t81A:
22.05
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5w1u CARBOXYLIC ESTER
HYDROLASE

(Culex
quinquefasciatus) 		PF00135
(COesterase) 		4 LEU A 120
TYR A 428
TYR A 105
HIS A 190
 EPE  A 600 ( 3.2A)
EPE  A 600 (-3.3A)
None
EPE  A 600 ( 4.5A)
 1.15A 4arcA-5w1uA:
undetectable		 4arcA-5w1uA:
20.02
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6brk DEOXYNUCLEOSIDE
TRIPHOSPHATE
TRIPHOSPHOHYDROLASE
SAMHD1

(Mus musculus) 		no annotation 4 LEU A 182
TYR A 347
ASP A 351
HIS A 413
 DGT  A 701 (-4.4A)
DGT  A 701 (-3.8A)
DGT  A 701 (-3.2A)
None
 1.32A 4arcA-6brkA:
undetectable		 4arcA-6brkA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6esl BACTERIAL LEUCYL
AMINOPEPTIDASE

(Legionella
pneumophila) 		no annotation 4 LEU A 245
TYR A 238
SER A 319
HIS A 321
 None
None
ZN  A 402 ( 4.6A)
None
 1.11A 4arcA-6eslA:
undetectable		 4arcA-6eslA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6fb3 TENEURIN-2

(Gallus gallus) 		no annotation 4 ASP A1200
SER A1202
TYR A1647
HIS A1212
 None
 1.17A 4arcA-6fb3A:
undetectable		 4arcA-6fb3A:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6fb3 TENEURIN-2

(Gallus gallus) 		no annotation 4 SER A1202
TYR A1647
HIS A1630
HIS A1212
 None
 1.38A 4arcA-6fb3A:
undetectable		 4arcA-6fb3A:
undetectable