SIMILAR PATTERNS OF AMINO ACIDS FOR 4AQL_A_TXCA1452_2

List of similar pattern of amino acids derived from ASSAM search

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click link on the last column to view superposed patterns of amino acids in NGL viewer)
(Note that only 3-12 residue patterns can be used for ASSAM searches)
Filter list by:
Hit Macromolecule/
Organism		 Pfam Res. Interface HETATM RMSD Dali Z-score Seq. Identity (%) View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1b24 PROTEIN (I-DMOI)

(Desulfurococcus
mucosus) 		PF14528
(LAGLIDADG_3) 		4 HIS A 152
LEU A 142
LEU A 125
ASP A 169
 None
 1.27A 4aqlA-1b24A:
undetectable		 4aqlA-1b24A:
16.49
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1bqg D-GLUCARATE
DEHYDRATASE

(Pseudomonas
putida) 		PF02746
(MR_MLE_N)
PF13378
(MR_MLE_C) 		4 HIS A 416
LEU A  71
LEU A  19
ASP A  73
 None
 1.31A 4aqlA-1bqgA:
3.8		 4aqlA-1bqgA:
20.16
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1dmw PHENYLALANINE
HYDROXYLASE

(Homo sapiens) 		PF00351
(Biopterin_H) 		4 HIS A 170
LEU A 227
LEU A 234
ASP A 229
 None
 1.17A 4aqlA-1dmwA:
undetectable		 4aqlA-1dmwA:
21.68
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1drt CLAVAMINATE SYNTHASE
1

(Streptomyces
clavuligerus) 		PF02668
(TauD) 		4 HIS A 108
LEU A 270
LEU A  63
ASP A 268
 None
 1.30A 4aqlA-1drtA:
undetectable		 4aqlA-1drtA:
22.42
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1fwx NITROUS OXIDE
REDUCTASE

(Paracoccus
denitrificans) 		PF13473
(Cupredoxin_1) 		4 HIS A 270
LEU A  78
LEU A 130
ASP A  99
 CUZ  A4801 (-3.2A)
None
None
None
 1.23A 4aqlA-1fwxA:
undetectable		 4aqlA-1fwxA:
20.99
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1phz PROTEIN
(PHENYLALANINE
HYDROXYLASE)

(Rattus
norvegicus) 		PF00351
(Biopterin_H)
PF01842
(ACT) 		4 HIS A 170
LEU A 227
LEU A 234
ASP A 229
 None
 1.22A 4aqlA-1phzA:
undetectable		 4aqlA-1phzA:
21.16
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1rp1 PANCREATIC LIPASE
RELATED PROTEIN 1

(Canis lupus) 		PF00151
(Lipase)
PF01477
(PLAT) 		4 HIS A 151
LEU A 248
LEU A 213
ASP A 247
 None
 1.23A 4aqlA-1rp1A:
undetectable		 4aqlA-1rp1A:
22.30
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1szq 2-METHYLCITRATE
DEHYDRATASE

(Escherichia
coli) 		PF03972
(MmgE_PrpD) 		4 HIS A 346
LEU A 282
TRP A 110
ASP A 103
 None
 1.05A 4aqlA-1szqA:
undetectable		 4aqlA-1szqA:
20.66
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1tvd T CELL RECEPTOR

(Homo sapiens) 		PF07686
(V-set) 		4 HIS A  64
LEU A  92
LEU A 104
ASP A 102
 None
 1.28A 4aqlA-1tvdA:
undetectable		 4aqlA-1tvdA:
14.10
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1um1 KIAA1849 PROTEIN

(Homo sapiens) 		PF00595
(PDZ) 		4 HIS A  83
LEU A  25
LEU A  69
ASP A  27
 None
 1.31A 4aqlA-1um1A:
undetectable		 4aqlA-1um1A:
14.20
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1umi F-BOX ONLY PROTEIN 2

(Mus musculus) 		PF04300
(FBA) 		4 LEU A 188
TRP A 194
LEU A 127
ASP A 187
 None
 1.22A 4aqlA-1umiA:
undetectable		 4aqlA-1umiA:
17.39
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1vli SPORE COAT
POLYSACCHARIDE
BIOSYNTHESIS PROTEIN
SPSE

(Bacillus
subtilis) 		PF03102
(NeuB)
PF08666
(SAF) 		4 HIS A 214
LEU A 232
LEU A 106
ASP A  47
 ZN  A 374 (-3.5A)
None
None
None
 1.29A 4aqlA-1vliA:
3.8		 4aqlA-1vliA:
21.41
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1z5y THIOL:DISULFIDE
INTERCHANGE PROTEIN
DSBE

(Escherichia
coli) 		PF08534
(Redoxin) 		4 HIS E  87
LEU E 127
LEU E  73
ASP E 129
 None
 1.27A 4aqlA-1z5yE:
undetectable		 4aqlA-1z5yE:
14.14
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2atf CYSTEINE DIOXYGENASE
TYPE I

(Mus musculus) 		PF05995
(CDO_I) 		4 HIS A 140
LEU A 154
TRP A  77
LEU A 156
 NI  A 201 (-3.3A)
None
None
None
 1.31A 4aqlA-2atfA:
undetectable		 4aqlA-2atfA:
17.70
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2bdw HYPOTHETICAL PROTEIN
K11E8.1D

(Caenorhabditis
elegans) 		PF00069
(Pkinase) 		4 HIS A 127
LEU A 252
LEU A 203
ASP A 249
 None
 1.26A 4aqlA-2bdwA:
undetectable		 4aqlA-2bdwA:
21.62
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2d40 PUTATIVE GENTISATE
1,2-DIOXYGENASE

(Escherichia
coli) 		PF07883
(Cupin_2) 		4 LEU A  73
TRP A  45
LEU A 163
ASP A 159
 None
 1.33A 4aqlA-2d40A:
undetectable		 4aqlA-2d40A:
22.98
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2dut HETEROCHROMATIN-ASSO
CIATED PROTEIN MENT

(Gallus gallus) 		PF00079
(Serpin) 		4 HIS A  59
LEU A 312
LEU A  19
ASP A 314
 None
 1.13A 4aqlA-2dutA:
undetectable		 4aqlA-2dutA:
22.20
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2ehb CALCINEURIN B-LIKE
PROTEIN 4
CBL-INTERACTING
SERINE/THREONINE-PRO
TEIN KINASE 24

(Arabidopsis
thaliana) 		PF03822
(NAF)
PF13202
(EF-hand_5)
PF13499
(EF-hand_7) 		4 HIS A 103
LEU D 327
LEU A  41
ASP D 329
 None
 1.26A 4aqlA-2ehbA:
undetectable		 4aqlA-2ehbA:
19.46
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2fkz BACTERIOFERRITIN

(Azotobacter
vinelandii) 		PF00210
(Ferritin) 		4 HIS A 130
LEU A  58
LEU A  19
ASP A  56
 FE2  A1601 ( 4.7A)
None
None
None
 1.29A 4aqlA-2fkzA:
undetectable		 4aqlA-2fkzA:
16.08
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2g0f THIOL:DISULFIDE
INTERCHANGE PROTEIN
DSBE

(Escherichia
coli) 		PF08534
(Redoxin) 		4 HIS A  87
LEU A 127
LEU A  73
ASP A 129
 None
 1.33A 4aqlA-2g0fA:
undetectable		 4aqlA-2g0fA:
16.10
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2gq0 CHAPERONE PROTEIN
HTPG

(Escherichia
coli) 		PF00183
(HSP90) 		4 HIS A 265
LEU A 348
LEU A 299
ASP A 329
 None
 1.30A 4aqlA-2gq0A:
undetectable		 4aqlA-2gq0A:
19.11
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2ppl PANCREATIC
LIPASE-RELATED
PROTEIN 1

(Homo sapiens) 		PF00151
(Lipase)
PF01477
(PLAT) 		4 HIS A 170
LEU A 266
LEU A 231
ASP A 265
 None
 1.23A 4aqlA-2pplA:
undetectable		 4aqlA-2pplA:
23.58
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2qzc TRANSCRIPTIONAL
ACTIVATOR TENA-1

(Sulfolobus
solfataricus) 		PF03070
(TENA_THI-4) 		4 HIS A  88
LEU A  37
LEU A  35
ASP A  38
 None
 1.18A 4aqlA-2qzcA:
undetectable		 4aqlA-2qzcA:
20.04
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2r6f EXCINUCLEASE ABC
SUBUNIT A

(Geobacillus
stearothermophilus) 		PF00005
(ABC_tran) 		4 HIS A 660
LEU A 852
LEU A 882
ASP A 853
 None
 1.19A 4aqlA-2r6fA:
2.4		 4aqlA-2r6fA:
19.65
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2rad SUCCINOGLYCAN
BIOSYNTHESIS PROTEIN

(Bacillus cereus) 		PF05139
(Erythro_esteras) 		4 HIS A  95
LEU A 122
TRP A 304
ASP A 123
 None
 1.24A 4aqlA-2radA:
undetectable		 4aqlA-2radA:
22.09
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2vrk ALPHA-L-ARABINOFURAN
OSIDASE

(Thermobacillus
xylanilyticus) 		PF06964
(Alpha-L-AF_C) 		4 HIS A 334
LEU A 324
LEU A 447
ASP A 322
 None
 0.83A 4aqlA-2vrkA:
4.4		 4aqlA-2vrkA:
21.23
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2vrk ALPHA-L-ARABINOFURAN
OSIDASE

(Thermobacillus
xylanilyticus) 		PF06964
(Alpha-L-AF_C) 		4 HIS A 378
LEU A 324
LEU A 447
ASP A 322
 None
 0.97A 4aqlA-2vrkA:
4.4		 4aqlA-2vrkA:
21.23
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2wjs LAMININ SUBUNIT
ALPHA-2

(Mus musculus) 		PF00054
(Laminin_G_1) 		4 HIS A2257
LEU A2203
LEU A2191
ASP A2205
 NAG  A4001 (-3.5A)
None
None
None
 1.26A 4aqlA-2wjsA:
undetectable		 4aqlA-2wjsA:
22.31
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2xvg ALPHA XYLOSIDASE

(Cellvibrio
japonicus) 		PF01055
(Glyco_hydro_31)
PF16338
(DUF4968)
PF17137
(DUF5110) 		4 HIS A 352
LEU A 241
LEU A 308
ASP A 275
 None
 1.28A 4aqlA-2xvgA:
3.5		 4aqlA-2xvgA:
18.68
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2ywb GMP SYNTHASE
[GLUTAMINE-HYDROLYZI
NG]

(Thermus
thermophilus) 		PF00117
(GATase)
PF00958
(GMP_synt_C) 		4 HIS A 164
LEU A   5
LEU A  83
ASP A  32
 None
 1.06A 4aqlA-2ywbA:
undetectable		 4aqlA-2ywbA:
22.88
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2z00 DIHYDROOROTASE

(Thermus
thermophilus) 		PF01979
(Amidohydro_1) 		4 HIS A  55
LEU A  73
LEU A 103
ASP A  68
 ZN  A1004 (-3.2A)
None
None
None
 1.23A 4aqlA-2z00A:
19.6		 4aqlA-2z00A:
22.11
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2zbl PUTATIVE ISOMERASE

(Salmonella
enterica) 		PF07221
(GlcNAc_2-epim) 		4 HIS A   9
LEU A 352
LEU A 384
ASP A 354
 None
 1.22A 4aqlA-2zblA:
undetectable		 4aqlA-2zblA:
20.35
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3b2d CD180 ANTIGEN

(Homo sapiens) 		PF00560
(LRR_1)
PF13855
(LRR_8) 		4 HIS A  69
LEU A 106
LEU A  79
ASP A  83
 None
 1.33A 4aqlA-3b2dA:
undetectable		 4aqlA-3b2dA:
21.50
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3bg2 DGTP
TRIPHOSPHOHYDROLASE

(Leeuwenhoekiella
blandensis) 		PF01966
(HD) 		4 HIS A 243
LEU A 338
LEU A  79
ASP A 254
 None
 1.31A 4aqlA-3bg2A:
undetectable		 4aqlA-3bg2A:
22.66
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3czq PUTATIVE
POLYPHOSPHATE KINASE
2

(Sinorhizobium
meliloti) 		PF03976
(PPK2) 		4 HIS A 189
TRP A  77
LEU A  67
ASP A 280
 None
 1.22A 4aqlA-3czqA:
undetectable		 4aqlA-3czqA:
19.68
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3dbx CD1-2 ANTIGEN

(Gallus gallus) 		PF07654
(C1-set)
PF16497
(MHC_I_3) 		4 HIS A 102
LEU A 107
TRP A 114
LEU A  35
 None
 1.28A 4aqlA-3dbxA:
undetectable		 4aqlA-3dbxA:
21.40
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ddm PUTATIVE MANDELATE
RACEMASE/MUCONATE
LACTONIZING ENZYME

(Bordetella
bronchiseptica) 		PF02746
(MR_MLE_N)
PF13378
(MR_MLE_C) 		4 HIS A 308
LEU A 176
LEU A 227
ASP A 185
 None
 1.21A 4aqlA-3ddmA:
6.4		 4aqlA-3ddmA:
21.74
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3dmk DOWN SYNDROME CELL
ADHESION MOLECULE
(DSCAM) ISOFORM
1.30.30, N-TERMINAL
EIGHT IG DOMAINS

(Drosophila
melanogaster) 		PF07679
(I-set)
PF13927
(Ig_3) 		4 HIS A 483
LEU A 430
TRP A 428
ASP A 466
 None
 1.18A 4aqlA-3dmkA:
undetectable		 4aqlA-3dmkA:
21.02
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3e0l GUANINE DEAMINASE

(Homo sapiens) 		PF01979
(Amidohydro_1) 		4 HIS A  84
LEU A 100
TRP A 102
ASP A 244
 ZN  A1452 (-3.1A)
None
None
None
 1.04A 4aqlA-3e0lA:
66.7		 4aqlA-3e0lA:
94.33
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3e3b CASEIN KINASE II
SUBUNIT ALPHA'

(Homo sapiens) 		PF00069
(Pkinase) 		4 HIS X 149
LEU X 306
LEU X 223
ASP X 303
 None
 1.03A 4aqlA-3e3bX:
undetectable		 4aqlA-3e3bX:
21.65
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3g0i EPOXIDE HYDROLASE

(Aspergillus
niger) 		PF06441
(EHN) 		4 HIS A 312
LEU A 176
LEU A 114
ASP A 174
 None
 1.33A 4aqlA-3g0iA:
2.1		 4aqlA-3g0iA:
20.33
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3gsi N,N-DIMETHYLGLYCINE
OXIDASE

(Arthrobacter
globiformis) 		PF01266
(DAO)
PF01571
(GCV_T)
PF08669
(GCV_T_C)
PF16350
(FAO_M) 		4 HIS A 225
TRP A 361
LEU A 147
ASP A 145
 FAD  A 902 (-4.3A)
None
None
None
 1.09A 4aqlA-3gsiA:
undetectable		 4aqlA-3gsiA:
21.42
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3gvy BACTERIOFERRITIN

(Rhodobacter
sphaeroides) 		PF00210
(Ferritin) 		4 HIS A 130
LEU A  58
LEU A  19
ASP A  56
 None
 1.15A 4aqlA-3gvyA:
undetectable		 4aqlA-3gvyA:
16.74
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3hba PUTATIVE
PHOSPHOSUGAR
ISOMERASE

(Shewanella
denitrificans) 		PF01380
(SIS) 		4 HIS A  54
LEU A 209
LEU A 206
ASP A 257
 None
 1.06A 4aqlA-3hbaA:
undetectable		 4aqlA-3hbaA:
22.50
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3igh UNCHARACTERIZED
METAL-DEPENDENT
HYDROLASE

(Pyrococcus
horikoshii) 		PF07969
(Amidohydro_3) 		4 HIS X 379
LEU X 213
LEU X  93
ASP X 215
 SO4  X   4 (-4.0A)
None
None
None
 1.33A 4aqlA-3ighX:
3.1		 4aqlA-3ighX:
23.26
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3jwe MGLL PROTEIN

(Homo sapiens) 		PF12146
(Hydrolase_4) 		4 HIS A 113
LEU A  80
LEU A 124
ASP A  79
 None
 1.32A 4aqlA-3jweA:
2.9		 4aqlA-3jweA:
24.44
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3kl8 CALCIUM/CALMODULIN
DEPENDENT PROTEIN
KINASE II

(Caenorhabditis
elegans) 		PF00069
(Pkinase) 		4 HIS A 127
LEU A 251
LEU A 202
ASP A 248
 None
 1.30A 4aqlA-3kl8A:
undetectable		 4aqlA-3kl8A:
19.29
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3m3i PUTATIVE
UNCHARACTERIZED
PROTEIN

(Leishmania
major) 		PF06172
(Cupin_5) 		4 HIS A  66
LEU A  84
LEU A  58
ASP A  82
 None
 1.18A 4aqlA-3m3iA:
undetectable		 4aqlA-3m3iA:
15.38
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3mzb NICKEL-BINDING
PERIPLASMIC PROTEIN

(Escherichia
coli) 		PF00496
(SBP_bac_5) 		4 HIS A 459
LEU A 269
LEU A 251
ASP A 363
 ACT  A 502 (-3.8A)
None
None
None
 1.30A 4aqlA-3mzbA:
undetectable		 4aqlA-3mzbA:
24.28
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3nk4 ZONA PELLUCIDA 3

(Gallus gallus) 		PF00100
(Zona_pellucida) 		4 HIS A 219
LEU A 297
LEU A 274
ASP A 227
 None
 1.22A 4aqlA-3nk4A:
undetectable		 4aqlA-3nk4A:
18.48
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3nyb POLY(A) RNA
POLYMERASE PROTEIN 2
PROTEIN AIR2

(Saccharomyces
cerevisiae) 		PF00098
(zf-CCHC)
PF01909
(NTP_transf_2)
PF03828
(PAP_assoc) 		4 LEU A 179
TRP B 140
LEU A 372
ASP A 177
 None
 1.33A 4aqlA-3nybA:
undetectable		 4aqlA-3nybA:
21.24
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3oz6 MITOGEN-ACTIVATED
PROTEIN KINASE 1,
SERINE/THREONINE
PROTEIN KINASE

(Cryptosporidium
parvum) 		PF00069
(Pkinase) 		4 HIS A 126
LEU A 313
LEU A 221
ASP A 310
 None
 1.05A 4aqlA-3oz6A:
undetectable		 4aqlA-3oz6A:
23.09
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3rv1 K. POLYSPORUS DCR1

(Vanderwaltozyma
polyspora) 		PF00636
(Ribonuclease_3) 		4 HIS A 123
LEU A 187
LEU A 194
ASP A 189
 None
 1.15A 4aqlA-3rv1A:
undetectable		 4aqlA-3rv1A:
23.01
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ux8 EXCINUCLEASE ABC, A
SUBUNIT

(Geobacillus sp.
Y412MC52) 		PF00005
(ABC_tran) 		4 HIS A 660
LEU A 852
LEU A 882
ASP A 853
 None
 1.25A 4aqlA-3ux8A:
undetectable		 4aqlA-3ux8A:
23.20
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3v7p AMIDOHYDROLASE
FAMILY PROTEIN

(Nitratiruptor
sp. SB155-2) 		PF01979
(Amidohydro_1) 		4 HIS A 206
LEU A 308
TRP A  81
LEU A  64
 FE  A 429 (-3.3A)
None
None
None
 1.33A 4aqlA-3v7pA:
40.4		 4aqlA-3v7pA:
24.25
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4a3q ALANINE RACEMASE 1

(Staphylococcus
aureus) 		PF00842
(Ala_racemase_C)
PF01168
(Ala_racemase_N) 		4 HIS A 369
LEU A 360
LEU A 331
ASP A 286
 None
 1.13A 4aqlA-4a3qA:
3.6		 4aqlA-4a3qA:
22.61
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4bwp PAB-DEPENDENT
POLY(A)-SPECIFIC
RIBONUCLEASE SUBUNIT
PAN-3

(Drosophila
melanogaster) 		no annotation 4 HIS A 474
LEU A 480
LEU A 532
ASP A 550
 None
 1.23A 4aqlA-4bwpA:
undetectable		 4aqlA-4bwpA:
22.54
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4cnk L-AMINO ACID OXIDASE

(Streptococcus
cristatus) 		PF03486
(HI0933_like) 		4 HIS A 231
LEU A 227
LEU A 240
ASP A 226
 None
 1.33A 4aqlA-4cnkA:
undetectable		 4aqlA-4cnkA:
20.97
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4do7 AMIDOHYDROLASE 2

(Burkholderia
multivorans) 		PF04909
(Amidohydro_2) 		4 HIS A   9
LEU A  42
LEU A 249
ASP A 255
 ZN  A 401 (-4.2A)
None
None
None
 1.29A 4aqlA-4do7A:
12.7		 4aqlA-4do7A:
20.75
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4h5y LIDA PROTEIN,
SUBSTRATE OF THE
DOT/ICM SYSTEM

(Legionella
pneumophila) 		no annotation 4 HIS A 317
LEU A 254
LEU A 394
ASP A 256
 None
 1.16A 4aqlA-4h5yA:
undetectable		 4aqlA-4h5yA:
23.71
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4hiz ENDOSIALIDASE

(Enterobacteria
phage phi92) 		PF12217
(End_beta_propel)
PF12218
(End_N_terminal)
PF12219
(End_tail_spike) 		4 HIS A 220
LEU A 349
LEU A 395
ASP A 351
 EDO  A 810 (-3.9A)
None
None
None
 1.16A 4aqlA-4hizA:
undetectable		 4aqlA-4hizA:
21.36
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4jc8 HOPS COMPONENT VPS33

(Chaetomium
thermophilum) 		PF00995
(Sec1) 		4 HIS A 108
LEU A  52
LEU A  21
ASP A  54
 None
 1.12A 4aqlA-4jc8A:
3.8		 4aqlA-4jc8A:
22.48
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4jza UNCHARACTERIZED
PROTEIN

(Legionella
longbeachae) 		no annotation 4 HIS A 354
LEU A 359
LEU A 148
ASP A 158
 None
 1.18A 4aqlA-4jzaA:
undetectable		 4aqlA-4jzaA:
21.55
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4md8 CASEIN KINASE II
SUBUNIT ALPHA

(Homo sapiens) 		PF00069
(Pkinase) 		4 HIS E 148
LEU E 305
LEU E 222
ASP E 302
 None
 0.97A 4aqlA-4md8E:
undetectable		 4aqlA-4md8E:
19.50
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4mkv RIBULOSE
BISPHOSPHATE
CARBOXYLASE LARGE
CHAIN

(Pisum sativum) 		PF00016
(RuBisCO_large)
PF02788
(RuBisCO_large_N) 		4 HIS A 294
LEU A 169
LEU A 400
ASP A 397
 RUB  A 501 ( 4.8A)
None
None
None
 1.30A 4aqlA-4mkvA:
5.9		 4aqlA-4mkvA:
21.11
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4mud RING OXYDATION
COMPLEX/
PHENYLACETIC ACID
DEGRADATION RELATED
PROTEIN

(Sulfolobus
solfataricus) 		PF05138
(PaaA_PaaC) 		4 HIS A 145
LEU A  30
LEU A  66
ASP A  27
 None
 1.19A 4aqlA-4mudA:
undetectable		 4aqlA-4mudA:
19.70
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ow8 SERINE/THREONINE-PRO
TEIN KINASE PKNA

(Mycobacterium
tuberculosis) 		PF00069
(Pkinase) 		4 HIS A 139
LEU A 122
LEU A 103
ASP A 120
 None
 1.33A 4aqlA-4ow8A:
undetectable		 4aqlA-4ow8A:
20.46
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4qtb MITOGEN-ACTIVATED
PROTEIN KINASE 3

(Homo sapiens) 		PF00069
(Pkinase) 		4 HIS A 158
LEU A 311
LEU A 235
ASP A 308
 None
 1.02A 4aqlA-4qtbA:
undetectable		 4aqlA-4qtbA:
21.29
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4toc BACTERIOFERRITIN

(Pseudomonas
aeruginosa) 		PF00210
(Ferritin) 		4 HIS A 130
LEU A  58
LEU A  19
ASP A  56
 FE2  A 205 (-4.0A)
None
None
HEM  A 207 ( 4.7A)
 1.29A 4aqlA-4tocA:
undetectable		 4aqlA-4tocA:
17.10
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4w8i PROBABLE
SPHINGOSINE-1-PHOSPH
ATE LYASE

(Legionella
pneumophila) 		PF00282
(Pyridoxal_deC) 		4 HIS A 477
LEU A 521
LEU A 501
ASP A 520
 None
 1.15A 4aqlA-4w8iA:
undetectable		 4aqlA-4w8iA:
22.65
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4x00 PUTATIVE HYDROLASE

(Burkholderia
cenocepacia) 		PF12697
(Abhydrolase_6) 		4 HIS A 102
LEU A  94
LEU A  24
ASP A  92
 None
 1.27A 4aqlA-4x00A:
undetectable		 4aqlA-4x00A:
21.63
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4xrl MITOGEN-ACTIVATED
PROTEIN KINASE 1

(Rattus
norvegicus) 		PF00069
(Pkinase) 		4 HIS A 139
LEU A 292
LEU A 216
ASP A 289
 None
 0.97A 4aqlA-4xrlA:
undetectable		 4aqlA-4xrlA:
22.52
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4y23 GAMMA GLUTAMYL
TRANSPEPTIDASE,GAMMA
-GLUTAMYLTRANSPEPTID
ASE

(Bacillus
licheniformis) 		PF01019
(G_glu_transpept) 		4 HIS A 277
LEU A 349
LEU A 300
ASP A 350
 None
 1.20A 4aqlA-4y23A:
undetectable		 4aqlA-4y23A:
21.70
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ydz STRESS-INDUCED
PROTEIN 1

(Caenorhabditis
elegans) 		PF00011
(HSP20) 		4 HIS A 111
LEU A  57
LEU A  67
ASP A  58
 None
 1.10A 4aqlA-4ydzA:
undetectable		 4aqlA-4ydzA:
15.32
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4z5y COENZYME PQQ
SYNTHESIS PROTEIN B

(Pseudomonas
putida) 		PF12706
(Lactamase_B_2) 		4 HIS A 307
LEU A 257
LEU A 208
ASP A 258
 None
 1.25A 4aqlA-4z5yA:
undetectable		 4aqlA-4z5yA:
20.79
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4zoy SQT1

(Chaetomium
thermophilum) 		PF00400
(WD40) 		4 HIS A  74
LEU A 221
LEU A 183
ASP A 222
 None
 1.34A 4aqlA-4zoyA:
undetectable		 4aqlA-4zoyA:
21.44
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4zxi TYROCIDINE
SYNTHETASE 3

(Acinetobacter
baumannii) 		PF00501
(AMP-binding)
PF00550
(PP-binding)
PF00668
(Condensation)
PF00975
(Thioesterase)
PF13193
(AMP-binding_C) 		4 HIS A  15
LEU A  69
LEU A 292
ASP A  65
 None
 1.30A 4aqlA-4zxiA:
undetectable		 4aqlA-4zxiA:
16.86
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5a3f DYNAMIN 3

(Homo sapiens) 		PF00169
(PH)
PF00350
(Dynamin_N)
PF01031
(Dynamin_M)
PF02212
(GED) 		4 HIS A 288
LEU A  16
LEU A  29
ASP A  18
 None
 1.16A 4aqlA-5a3fA:
undetectable		 4aqlA-5a3fA:
19.95
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5b5k IZUMO SPERM-EGG
FUSION PROTEIN 1

(Mus musculus) 		PF15005
(IZUMO)
PF16706
(Izumo-Ig) 		4 HIS A  44
LEU A  33
LEU A  91
ASP A  31
 None
None
EPE  A 302 ( 2.4A)
None
 1.08A 4aqlA-5b5kA:
undetectable		 4aqlA-5b5kA:
20.12
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5csa ACETYL-COA
CARBOXYLASE

(Saccharomyces
cerevisiae) 		PF00364
(Biotin_lipoyl)
PF08326
(ACC_central) 		4 HIS A 912
LEU A 850
LEU A 900
ASP A 859
 None
 0.95A 4aqlA-5csaA:
undetectable		 4aqlA-5csaA:
20.62
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5csl ACETYL-COA
CARBOXYLASE

(Saccharomyces
cerevisiae) 		PF00289
(Biotin_carb_N)
PF00364
(Biotin_lipoyl)
PF01039
(Carboxyl_trans)
PF02785
(Biotin_carb_C)
PF02786
(CPSase_L_D2)
PF08326
(ACC_central) 		4 HIS A 912
LEU A 850
LEU A 900
ASP A 859
 None
 0.93A 4aqlA-5cslA:
2.1		 4aqlA-5cslA:
12.60
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5gui CHAPERONE PROTEIN
CLPC1, CHLOROPLASTIC

(Arabidopsis
thaliana) 		PF02861
(Clp_N) 		4 HIS A 118
LEU A 149
LEU A 127
ASP A 151
 None
 1.09A 4aqlA-5guiA:
undetectable		 4aqlA-5guiA:
15.30
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5hss LINALOOL
DEHYDRATASE/ISOMERAS
E

(Castellaniella
defragrans) 		no annotation 4 HIS A 249
LEU A 311
LEU A 300
ASP A 313
 None
 1.28A 4aqlA-5hssA:
undetectable		 4aqlA-5hssA:
22.61
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5hvm ALPHA,ALPHA-TREHALOS
E-PHOSPHATE SYNTHASE
(UDP-FORMING)

(Aspergillus
fumigatus) 		PF00982
(Glyco_transf_20) 		4 LEU A  14
TRP A  57
LEU A 474
ASP A 145
 None
 1.23A 4aqlA-5hvmA:
undetectable		 4aqlA-5hvmA:
21.03
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5i6e ACETYL-COA
CARBOXYLASE

(Saccharomyces
cerevisiae) 		PF08326
(ACC_central) 		4 HIS A 912
LEU A 850
LEU A 900
ASP A 859
 None
 1.05A 4aqlA-5i6eA:
undetectable		 4aqlA-5i6eA:
21.78
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5jk6 PHENYLALANINE-4-HYDR
OXYLASE

(Dictyostelium
discoideum) 		PF00351
(Biopterin_H) 		4 HIS A 158
LEU A 215
LEU A 222
ASP A 217
 None
 1.19A 4aqlA-5jk6A:
undetectable		 4aqlA-5jk6A:
24.90
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ktk POLYKETIDE SYNTHASE
PKSJ

(Bacillus
subtilis) 		PF08659
(KR) 		4 HIS A 158
TRP A  24
LEU A 173
ASP A 191
 None
 1.19A 4aqlA-5ktkA:
undetectable		 4aqlA-5ktkA:
23.02
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5l5n PLEXIN-A4

(Mus musculus) 		PF01403
(Sema)
PF01437
(PSI)
PF01833
(TIG) 		4 HIS A 490
LEU A 333
LEU A 314
ASP A 331
 HIS  A 490 ( 1.0A)
LEU  A 333 ( 0.5A)
LEU  A 314 ( 0.5A)
ASP  A 331 ( 0.5A)
 1.26A 4aqlA-5l5nA:
undetectable		 4aqlA-5l5nA:
18.56
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5lew DNA POLYMERASE III
SUBUNIT ALPHA

(Mycobacterium
tuberculosis) 		no annotation 4 HIS A 469
LEU A  22
LEU A 536
ASP A  23
 None
None
None
ZN  A1003 (-2.5A)
 1.12A 4aqlA-5lewA:
4.7		 4aqlA-5lewA:
20.11
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5mov CASEIN KINASE II
SUBUNIT ALPHA

(Homo sapiens) 		PF00069
(Pkinase) 		4 HIS A 148
LEU A 305
LEU A 222
ASP A 302
 None
 1.00A 4aqlA-5movA:
undetectable		 4aqlA-5movA:
20.04
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5oc1 ARYL-ALCOHOL OXIDASE

(Pleurotus
eryngii) 		no annotation 4 HIS A  91
LEU A 539
LEU A 553
ASP A 102
 FAD  A 602 (-4.3A)
None
None
None
 1.24A 4aqlA-5oc1A:
undetectable		 4aqlA-5oc1A:
20.20
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5toa ESTROGEN RECEPTOR
BETA

(Homo sapiens) 		PF00104
(Hormone_recep) 		4 HIS A 475
LEU A 301
LEU A 339
ASP A 303
 EST  A 601 (-4.4A)
EST  A 601 ( 4.3A)
EST  A 601 (-3.9A)
None
 1.25A 4aqlA-5toaA:
undetectable		 4aqlA-5toaA:
19.96
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5wiv D(4) DOPAMINE
RECEPTOR, SOLUBLE
CYTOCHROME B562
CHIMERA

(Escherichia
coli;
Homo sapiens) 		no annotation 4 HIS A 414
LEU A 118
LEU A  88
ASP A  80
 AQD  A1201 (-4.0A)
None
None
NA  A1224 (-3.2A)
 1.23A 4aqlA-5wivA:
undetectable		 4aqlA-5wivA:
20.49
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5xu1 ABC TRANSPORTER
ATP-BINDING PROTEIN

(Streptococcus
pneumoniae) 		no annotation 4 HIS A 202
LEU A  50
LEU A 167
ASP A  58
 None
 1.25A 4aqlA-5xu1A:
undetectable		 4aqlA-5xu1A:
10.99
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5za2 BETA-LACTAMASE

(Escherichia
coli) 		no annotation 4 HIS A 255
LEU A 231
LEU A  69
ASP A 230
 None
 1.32A 4aqlA-5za2A:
undetectable		 4aqlA-5za2A:
11.94
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6b2q SERINE/THREONINE-PRO
TEIN KINASE PKNA

(Mycobacterium
tuberculosis) 		no annotation 4 HIS A 139
LEU A 122
LEU A 103
ASP A 120
 None
None
None
0BD  A 302 (-4.3A)
 1.30A 4aqlA-6b2qA:
undetectable		 4aqlA-6b2qA:
12.18
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6b3e CYCLIN-DEPENDENT
KINASE 12

(Homo sapiens) 		no annotation 4 HIS A 851
LEU A1001
LEU A 926
ASP A 998
 None
 0.97A 4aqlA-6b3eA:
undetectable		 4aqlA-6b3eA:
10.36
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6czx PHOSPHOSERINE
AMINOTRANSFERASE 1,
CHLOROPLASTIC

(Arabidopsis
thaliana) 		no annotation 4 HIS A 215
LEU A 293
LEU A 141
ASP A 294
 None
None
None
SO4  A 501 ( 4.3A)
 1.12A 4aqlA-6czxA:
undetectable		 4aqlA-6czxA:
10.73
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6f0k ACTF

(Rhodothermus
marinus) 		no annotation 4 HIS F 224
LEU F 126
LEU F 367
ASP F 125
 None
 1.13A 4aqlA-6f0kF:
undetectable		 4aqlA-6f0kF:
9.87
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6f74 ALCOHOL OXIDASE

(Thermothelomyces
thermophila) 		no annotation 4 HIS A 246
TRP A 493
LEU A 162
ASP A 548
 FAD  A 601 (-3.3A)
None
None
None
 1.15A 4aqlA-6f74A:
undetectable		 4aqlA-6f74A:
11.02