SIMILAR PATTERNS OF AMINO ACIDS FOR 4AQ7_D_LEUD902_0

List of similar pattern of amino acids derived from ASSAM search

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click link on the last column to view superposed patterns of amino acids in NGL viewer)
(Note that only 3-12 residue patterns can be used for ASSAM searches)
Filter list by:
Hit Macromolecule/
Organism		 Pfam Res. Interface HETATM RMSD Dali Z-score Seq. Identity (%) View Dock
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1obh LEUCYL-TRNA
SYNTHETASE

(Thermus
thermophilus) 		PF00133
(tRNA-synt_1)
PF08264
(Anticodon_1)
PF13603
(tRNA-synt_1_2)
PF14795
(Leucyl-specific) 		6 MET A  40
ASP A  80
SER A 504
TYR A 507
TYR A 535
HIS A 545
 LMS  A1817 ( 3.7A)
NVA  A1816 (-3.9A)
NVA  A1816 ( 4.8A)
None
None
NVA  A1816 (-3.5A)
 0.38A 4aq7D-1obhA:
45.4		 4aq7D-1obhA:
45.70
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3bxz PREPROTEIN
TRANSLOCASE SUBUNIT
SECA

(Escherichia
coli) 		PF07517
(SecA_DEAD) 		5 LEU A 423
SER A 583
TYR A 587
GLU A 444
HIS A 555
 None
 1.31A 4aq7D-3bxzA:
0.0		 4aq7D-3bxzA:
20.00
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3ziu LEUCYL-TRNA
SYNTHETASE

(Mycoplasma
mobile) 		PF00133
(tRNA-synt_1)
PF08264
(Anticodon_1) 		8 MET A  43
ASP A  84
SER A 324
TYR A 327
TYR A 361
GLU A 366
HIS A 367
HIS A 371
 LSS  A1638 (-3.9A)
LSS  A1638 (-3.7A)
LSS  A1638 ( 3.9A)
LSS  A1638 (-4.8A)
None
LSS  A1638 (-3.0A)
LSS  A1638 (-3.8A)
LSS  A1638 (-3.7A)
 0.72A 4aq7D-3ziuA:
40.3		 4aq7D-3ziuA:
31.41
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4arc LEUCINE--TRNA LIGASE

(Escherichia
coli) 		PF00133
(tRNA-synt_1)
PF08264
(Anticodon_1)
PF13603
(tRNA-synt_1_2) 		8 MET A  40
LEU A  41
ASP A  80
SER A 496
TYR A 499
TYR A 527
HIS A 533
HIS A 537
 LEU  A1001 ( 4.3A)
LEU  A1001 (-4.9A)
LEU  A1001 (-3.9A)
LEU  A1001 ( 3.7A)
None
None
LEU  A1001 (-4.2A)
LEU  A1001 (-3.6A)
 0.43A 4aq7D-4arcA:
53.4		 4aq7D-4arcA:
100.00
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4arc LEUCINE--TRNA LIGASE

(Escherichia
coli) 		PF00133
(tRNA-synt_1)
PF08264
(Anticodon_1)
PF13603
(tRNA-synt_1_2) 		8 MET A  40
LEU A  41
SER A 496
TYR A 499
TYR A 527
GLU A 532
HIS A 533
HIS A 537
 LEU  A1001 ( 4.3A)
LEU  A1001 (-4.9A)
LEU  A1001 ( 3.7A)
None
None
None
LEU  A1001 (-4.2A)
LEU  A1001 (-3.6A)
 0.76A 4aq7D-4arcA:
53.4		 4aq7D-4arcA:
100.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ft2 DNA
(CYTOSINE-5)-METHYLT
RANSFERASE 1

(Zea mays) 		PF00145
(DNA_methylase)
PF00385
(Chromo)
PF01426
(BAH) 		5 LEU A 170
ASP A 259
TYR A 155
GLU A 212
HIS A 175
 None
 1.32A 4aq7D-4ft2A:
1.0		 4aq7D-4ft2A:
22.48
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5ah5 LEUCINE--TRNA LIGASE

(Agrobacterium
tumefaciens) 		PF00133
(tRNA-synt_1)
PF08264
(Anticodon_1)
PF13603
(tRNA-synt_1_2) 		8 MET A  38
ASP A  78
SER A 493
TYR A 496
TYR A 523
GLU A 528
HIS A 529
HIS A 533
 LSS  A1818 (-3.9A)
LSS  A1818 (-3.6A)
LSS  A1818 (-3.6A)
None
None
LSS  A1818 (-2.9A)
LSS  A1818 (-4.0A)
LSS  A1818 (-3.6A)
 0.85A 4aq7D-5ah5A:
42.5		 4aq7D-5ah5A:
38.53