SIMILAR PATTERNS OF AMINO ACIDS FOR 4AN2_A_EUIA1382_2
List of similar pattern of amino acids derived from ASSAM searchHit | Macromolecule/ Organism |
Pfam | Res. | Interface | HETATM | RMSD | Dali Z-score | Seq. Identity (%) | View | Dock | |
---|---|---|---|---|---|---|---|---|---|---|---|
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 1alq | CP254 BETA-LACTAMASE (Staphylococcusaureus) |
PF13354(Beta-lactamase2) | 4 | ASN A 191SER A 200LEU A 199THR A 51 | None | 1.47A | 4an2A-1alqA:0.0 | 4an2A-1alqA:22.64 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 1aun | PR-5D (Nicotianatabacum) |
PF00314(Thaumatin) | 4 | ASN A 106SER A 137LEU A 138THR A 64 | None | 1.28A | 4an2A-1aunA:0.0 | 4an2A-1aunA:18.94 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 1axk | GLUXYN-1 (Bacillussubtilis) |
PF00457(Glyco_hydro_11)PF00722(Glyco_hydro_16) | 4 | ASN A 208SER A 240LEU A 222THR A 206 | None | 1.42A | 4an2A-1axkA:undetectable | 4an2A-1axkA:19.76 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 1dkp | PHYTASE (Escherichiacoli) |
PF00328(His_Phos_2) | 4 | ASN A 251SER A 206LEU A 207THR A 327 | NoneNoneNone HG A 503 ( 3.7A) | 1.41A | 4an2A-1dkpA:0.3 | 4an2A-1dkpA:19.37 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 1fep | FERRIC ENTEROBACTINRECEPTOR (Escherichiacoli) |
PF00593(TonB_dep_Rec)PF07715(Plug) | 4 | ASN A 534SER A 590LEU A 599THR A 506 | None | 1.48A | 4an2A-1fepA:0.1 | 4an2A-1fepA:17.24 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 1fpq | ISOLIQUIRITIGENIN2'-O-METHYLTRANSFERASE (Medicago sativa) |
PF00891(Methyltransf_2)PF08100(Dimerisation) | 4 | ASN A 42SER A 94LEU A 91THR A 136 | None | 1.32A | 4an2A-1fpqA:0.7 | 4an2A-1fpqA:21.03 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 1fs2 | SKP2 (Homo sapiens) |
PF12937(F-box-like) | 4 | ASN A 236SER A 224LEU A 225THR A 262 | None | 1.36A | 4an2A-1fs2A:undetectable | 4an2A-1fs2A:21.36 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 1hwn | EBULIN (Sambucus ebulus) |
PF00161(RIP) | 4 | ASN A 61SER A 177LEU A 178THR A 142 | None | 1.46A | 4an2A-1hwnA:undetectable | 4an2A-1hwnA:21.34 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 1ikp | EXOTOXIN A (Pseudomonasaeruginosa) |
PF09009(Exotox-A_cataly)PF09101(Exotox-A_bind)PF09102(Exotox-A_target) | 4 | ASN A 112SER A 65LEU A 64THR A 273 | None NA A 703 ( 4.5A)NoneNone | 1.33A | 4an2A-1ikpA:0.4 | 4an2A-1ikpA:18.46 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 1kqf | FORMATEDEHYDROGENASE,NITRATE-INDUCIBLE,MAJOR SUBUNIT (Escherichiacoli) |
PF00384(Molybdopterin)PF01568(Molydop_binding)PF04879(Molybdop_Fe4S4) | 4 | ASN A 144SER A 461LEU A 187THR A 550 | None | 1.31A | 4an2A-1kqfA:undetectable | 4an2A-1kqfA:14.98 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 1mox | EPIDERMAL GROWTHFACTOR RECEPTOR (Homo sapiens) |
PF00757(Furin-like)PF01030(Recep_L_domain) | 4 | ASN A 40SER A 99LEU A 98THR A 10 | None | 1.30A | 4an2A-1moxA:undetectable | 4an2A-1moxA:21.87 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 1p9m | INTERLEUKIN-6RECEPTOR BETA CHAIN (Homo sapiens) |
PF00041(fn3)PF06328(Lep_receptor_Ig)PF09240(IL6Ra-bind) | 4 | ASN A 236SER A 207LEU A 206THR A 255 | None | 1.20A | 4an2A-1p9mA:undetectable | 4an2A-1p9mA:21.32 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 1r4n | AMYLOID BETAPRECURSORPROTEIN-BINDINGPROTEIN 1 (Homo sapiens) |
PF00899(ThiF) | 4 | ASN A 72SER A 523LEU A 158THR A 39 | None | 1.48A | 4an2A-1r4nA:undetectable | 4an2A-1r4nA:21.43 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 1umr | CONVULXIN BETA (Crotalusdurissus) |
PF00059(Lectin_C) | 4 | ASN C 306SER C 310LEU C 309THR C 247 | None | 1.45A | 4an2A-1umrC:undetectable | 4an2A-1umrC:15.05 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 1xp4 | D-ALANYL-D-ALANINECARBOXYPEPTIDASE (Streptococcuspneumoniae) |
PF00768(Peptidase_S11)PF07943(PBP5_C) | 4 | ASN A 163SER A 122LEU A 90THR A 243 | None | 1.22A | 4an2A-1xp4A:undetectable | 4an2A-1xp4A:20.73 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 1yts | YERSINIA PROTEINTYROSINE PHOSPHATASE (Yersiniaenterocolitica) |
PF00102(Y_phosphatase) | 4 | ASN A 424SER A 362LEU A 457THR A 254 | None | 1.49A | 4an2A-1ytsA:undetectable | 4an2A-1ytsA:22.59 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 1yz4 | DUAL SPECIFICITYPHOSPHATASE-LIKE 15ISOFORM A (Homo sapiens) |
PF00782(DSPc) | 4 | ASN A 83SER A 95LEU A 14THR A 32 | NoneSO4 A 211 ( 4.5A)NoneNone | 1.39A | 4an2A-1yz4A:undetectable | 4an2A-1yz4A:21.21 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 2ass | S-PHASEKINASE-ASSOCIATEDPROTEIN 2 (Homo sapiens) |
PF12937(F-box-like) | 4 | ASN B2224SER B2212LEU B2213THR B2250 | None | 1.28A | 4an2A-2assB:undetectable | 4an2A-2assB:21.95 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 2dpn | GLYCEROL KINASE (Thermusthermophilus) |
PF00370(FGGY_N)PF02782(FGGY_C) | 4 | ASN A 271SER A 279LEU A 283THR A 296 | None | 1.49A | 4an2A-2dpnA:undetectable | 4an2A-2dpnA:20.08 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 2e0i | 432AA LONGHYPOTHETICALDEOXYRIBODIPYRIMIDINE PHOTOLYASE (Sulfurisphaeratokodaii) |
PF00875(DNA_photolyase)PF03441(FAD_binding_7) | 4 | ASN A 145SER A 133LEU A 134THR A 141 | None | 1.32A | 4an2A-2e0iA:undetectable | 4an2A-2e0iA:22.69 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 2eae | ALPHA-FUCOSIDASE (Bifidobacteriumbifidum) |
PF14498(Glyco_hyd_65N_2) | 4 | ASN A 695SER A 730LEU A 685THR A 785 | None | 1.41A | 4an2A-2eaeA:undetectable | 4an2A-2eaeA:15.46 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 2eae | ALPHA-FUCOSIDASE (Bifidobacteriumbifidum) |
PF14498(Glyco_hyd_65N_2) | 4 | ASN A 755SER A 162LEU A 161THR A 61 | None | 1.42A | 4an2A-2eaeA:undetectable | 4an2A-2eaeA:15.46 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 2gtr | CHROMODOMAIN Y-LIKEPROTEIN (Homo sapiens) |
PF00378(ECH_1) | 4 | ASN A 31SER A 118LEU A 115THR A 22 | None | 1.46A | 4an2A-2gtrA:undetectable | 4an2A-2gtrA:22.39 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 2hga | CONSERVED PROTEINMTH1368 (Methanothermobacterthermautotrophicus) |
PF00595(PDZ) | 4 | ASN A 76SER A 63LEU A 66THR A 78 | None | 1.41A | 4an2A-2hgaA:undetectable | 4an2A-2hgaA:18.56 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 2ivf | ETHYLBENZENEDEHYDROGENASEALPHA-SUBUNIT (Aromatoleumaromaticum) |
PF00384(Molybdopterin)PF01568(Molydop_binding) | 4 | ASN A 958SER A 214LEU A 543THR A 224 | NoneNoneNoneGOL A1980 ( 4.9A) | 1.37A | 4an2A-2ivfA:undetectable | 4an2A-2ivfA:15.22 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 2j5g | ALR4455 PROTEIN (Nostoc sp. PCC7120) |
PF00378(ECH_1) | 4 | ASN D 14SER D 112LEU D 64THR D 31 | None | 1.15A | 4an2A-2j5gD:undetectable | 4an2A-2j5gD:23.05 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 2ka9 | DISKS LARGE HOMOLOG4 (Rattusnorvegicus) |
PF00595(PDZ) | 4 | ASN A 156SER A 128LEU A 153THR A 175 | None | 1.32A | 4an2A-2ka9A:undetectable | 4an2A-2ka9A:24.44 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 2o0y | TRANSCRIPTIONALREGULATOR (Rhodococcus sp.) |
PF01614(IclR)PF09339(HTH_IclR) | 4 | ASN A 115SER A 252LEU A 212THR A 113 | None | 1.47A | 4an2A-2o0yA:undetectable | 4an2A-2o0yA:22.26 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 2wiu | HTH-TYPETRANSCRIPTIONALREGULATOR HIPB (Escherichiacoli) |
PF01381(HTH_3) | 4 | ASN B 15SER B 63LEU B 64THR B 11 | None | 1.44A | 4an2A-2wiuB:undetectable | 4an2A-2wiuB:15.59 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 2wl7 | DISKS LARGE HOMOLOG2 (Mus musculus) |
PF00595(PDZ) | 4 | ASN A 149SER A 161LEU A 153THR A 132 | CL A1193 (-4.3A)NoneNoneNone | 1.25A | 4an2A-2wl7A:undetectable | 4an2A-2wl7A:21.96 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3a1z | HEMOLYMPH JUVENILEHORMONE BINDINGPROTEIN (Bombyx mori) |
PF06585(JHBP) | 4 | ASN A 66SER A 162LEU A 115THR A 68 | None | 0.96A | 4an2A-3a1zA:undetectable | 4an2A-3a1zA:21.24 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3c0r | UBIQUITINTHIOESTERASE OTU1 (Saccharomycescerevisiae) |
PF02338(OTU) | 4 | ASN A 255SER A 225LEU A 226THR A 259 | None | 1.25A | 4an2A-3c0rA:undetectable | 4an2A-3c0rA:23.10 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3d3m | EUKARYOTICTRANSLATIONINITIATION FACTOR 4GAMMA 2 (Homo sapiens) |
PF02020(W2) | 4 | ASN A 770SER A 759LEU A 762THR A 774 | None | 1.14A | 4an2A-3d3mA:undetectable | 4an2A-3d3mA:19.80 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3dwk | PENICILLIN-BINDINGPROTEIN 2 (Staphylococcusaureus) |
PF00905(Transpeptidase)PF00912(Transgly) | 4 | ASN A 418SER A 454LEU A 451THR A 687 | NoneSO4 A 26 (-3.1A)NoneNone | 1.48A | 4an2A-3dwkA:undetectable | 4an2A-3dwkA:18.38 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3hs3 | RIBOSE OPERONREPRESSOR (Lactobacillusacidophilus) |
PF13377(Peripla_BP_3) | 4 | ASN A 235SER A 182LEU A 183THR A 233 | None | 1.37A | 4an2A-3hs3A:undetectable | 4an2A-3hs3A:24.69 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3hur | ALANINE RACEMASE (Oenococcus oeni) |
PF00842(Ala_racemase_C)PF01168(Ala_racemase_N) | 4 | ASN A 204SER A 59LEU A 22THR A 207 | SO4 A 395 (-4.0A)NoneNoneNone | 1.38A | 4an2A-3hurA:undetectable | 4an2A-3hurA:23.41 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3ilv | GLUTAMINE-DEPENDENTNAD(+) SYNTHETASE (Cytophagahutchinsonii) |
PF00795(CN_hydrolase)PF02540(NAD_synthase) | 4 | ASN A 12SER A 82LEU A 42THR A 14 | None | 1.34A | 4an2A-3ilvA:undetectable | 4an2A-3ilvA:20.57 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3jcl | SPIKE GLYCOPROTEIN (Murinecoronavirus) |
PF01601(Corona_S2)PF09408(Spike_rec_bind)PF16451(Spike_NTD) | 4 | ASN A1048SER A1026LEU A1027THR A1052 | None | 1.48A | 4an2A-3jclA:1.6 | 4an2A-3jclA:13.22 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3l6a | EUKARYOTICTRANSLATIONINITIATION FACTOR 4GAMMA 2 (Homo sapiens) |
PF02020(W2)PF02847(MA3) | 4 | ASN A 233SER A 222LEU A 225THR A 237 | None | 1.16A | 4an2A-3l6aA:undetectable | 4an2A-3l6aA:23.47 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3mkl | HTH-TYPETRANSCRIPTIONALREGULATOR GADX (Escherichiacoli) |
PF12833(HTH_18) | 4 | ASN A 142SER A 171LEU A 174THR A 145 | None | 1.17A | 4an2A-3mklA:undetectable | 4an2A-3mklA:18.43 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3pnt | IMMUNITY FACTOR FORSPN (Streptococcuspyogenes) |
PF16718(IFS) | 4 | ASN B 97SER B 108LEU B 109THR B 160 | None | 1.33A | 4an2A-3pntB:undetectable | 4an2A-3pntB:21.19 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3qk8 | ENOYL-COA HYDRATASEECHA15 (Mycobacteriummarinum) |
PF00378(ECH_1) | 4 | ASN A 22SER A 67LEU A 25THR A 199 | None | 1.30A | 4an2A-3qk8A:undetectable | 4an2A-3qk8A:22.91 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3rks | HYDROXYNITRILASE (Manihotesculenta) |
PF00561(Abhydrolase_1) | 4 | ASN A 52SER A 115LEU A 184THR A 140 | None | 1.42A | 4an2A-3rksA:undetectable | 4an2A-3rksA:21.10 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3rpi | LIGHT CHAIN FROMHIGHLY POTENTANTI-HIVNEUTRALIZINGANTIBODY (Homo sapiens) |
no annotation | 4 | ASN L 126SER L 191LEU L 190THR L 161 | None | 1.43A | 4an2A-3rpiL:undetectable | 4an2A-3rpiL:22.76 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3rpi | LIGHT CHAIN FROMHIGHLY POTENTANTI-HIVNEUTRALIZINGANTIBODY (Homo sapiens) |
no annotation | 4 | ASN L 127SER L 191LEU L 190THR L 161 | None | 1.49A | 4an2A-3rpiL:undetectable | 4an2A-3rpiL:22.76 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3ss7 | D-SERINE DEHYDRATASE (Escherichiacoli) |
PF00291(PALP) | 4 | ASN X 170SER X 241LEU X 244THR X 424 | PLP X 502 (-3.8A)NoneNonePLP X 502 (-3.0A) | 1.36A | 4an2A-3ss7X:undetectable | 4an2A-3ss7X:21.30 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3sy8 | ROCR (Pseudomonasaeruginosa) |
PF00072(Response_reg)PF00563(EAL) | 4 | ASN A 233SER A 241LEU A 244THR A 267 | MG A 401 (-2.7A)NoneNoneNone | 1.31A | 4an2A-3sy8A:undetectable | 4an2A-3sy8A:24.11 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3t8j | PURINE NUCLEOSIDASE,(IUNH-1) (Sulfolobussolfataricus) |
PF01156(IU_nuc_hydro) | 4 | ASN A 309SER A 17LEU A 20THR A 208 | None | 1.49A | 4an2A-3t8jA:undetectable | 4an2A-3t8jA:21.41 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3tht | ALKYLATED DNA REPAIRPROTEIN ALKB HOMOLOG8 (Homo sapiens) |
PF00076(RRM_1)PF13532(2OG-FeII_Oxy_2) | 4 | ASN A 49SER A 93LEU A 45THR A 114 | None | 1.45A | 4an2A-3thtA:undetectable | 4an2A-3thtA:23.06 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3tql | ARGININE-BINDINGPROTEIN (Coxiellaburnetii) |
PF00497(SBP_bac_3) | 4 | ASN A 109SER A 91LEU A 92THR A 111 | ARG A 1 (-3.6A)NoneNoneNone | 1.32A | 4an2A-3tqlA:undetectable | 4an2A-3tqlA:21.52 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3twi | VARIABLE LYMPHOCYTERECEPTOR B (Petromyzonmarinus) |
PF01462(LRRNT)PF13855(LRR_8) | 4 | ASN D 34SER D 42LEU D 40THR D 32 | None | 1.41A | 4an2A-3twiD:undetectable | 4an2A-3twiD:20.60 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3v98 | ARACHIDONATE5-LIPOXYGENASE (Homo sapiens) |
PF00305(Lipoxygenase)PF01477(PLAT) | 4 | ASN A 407SER A 608LEU A 607THR A 403 | None | 1.37A | 4an2A-3v98A:undetectable | 4an2A-3v98A:18.68 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3vzm | ENDO-1,4-BETA-XYLANASE (Bacilluscirculans) |
PF00457(Glyco_hydro_11) | 4 | ASN A 52SER A 84LEU A 66THR A 50 | None | 1.40A | 4an2A-3vzmA:undetectable | 4an2A-3vzmA:17.55 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3w0s | HYGROMYCIN-B4-O-KINASE (Escherichiacoli) |
PF01636(APH) | 4 | ASN A 203SER A 69LEU A 72THR A 99 | ANP A 402 ( 4.6A)NoneNoneNone | 1.40A | 4an2A-3w0sA:6.6 | 4an2A-3w0sA:22.82 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3znj | 5-CHLOROMUCONOLACTONE DEHALOGENASE (Rhodococcusopacus) |
PF02426(MIase) | 4 | ASN 1 10SER 1 26LEU 1 23THR 1 8 | None | 1.31A | 4an2A-3znj1:undetectable | 4an2A-3znj1:14.48 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3znj | 5-CHLOROMUCONOLACTONE DEHALOGENASE (Rhodococcusopacus) |
PF02426(MIase) | 4 | ASN 1 10SER 1 26LEU 1 23THR 1 78 | None | 1.48A | 4an2A-3znj1:undetectable | 4an2A-3znj1:14.48 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4anj | UNCONVENTIONALMYOSIN-VI, GREENFLUORESCENT PROTEIN (Aequoreavictoria;Sus scrofa) |
PF00063(Myosin_head)PF01353(GFP) | 4 | ASN A 76SER A 687LEU A 686THR A 88 | None | 1.31A | 4an2A-4anjA:1.4 | 4an2A-4anjA:14.49 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4arv | PHYTASE (Yersiniakristensenii) |
PF00328(His_Phos_2) | 4 | ASN A 171SER A 247LEU A 165THR A 34 | None | 1.19A | 4an2A-4arvA:undetectable | 4an2A-4arvA:22.53 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4buj | ANTIVIRAL PROTEINSKI8 (Saccharomycescerevisiae) |
PF00400(WD40) | 4 | ASN C 222SER C 195LEU C 199THR C 208 | None | 1.30A | 4an2A-4bujC:undetectable | 4an2A-4bujC:22.63 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4c23 | L-FUCULOSE KINASEFUCK (Streptococcuspneumoniae) |
PF00370(FGGY_N)PF02782(FGGY_C) | 4 | ASN A 124SER A 110LEU A 115THR A 177 | None | 1.43A | 4an2A-4c23A:undetectable | 4an2A-4c23A:21.13 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4cvu | BETA-MANNOSIDASE (Trichodermaharzianum) |
PF00703(Glyco_hydro_2) | 4 | ASN A 855SER A 884LEU A 885THR A 658 | None | 1.49A | 4an2A-4cvuA:undetectable | 4an2A-4cvuA:16.51 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4dgu | PUTATIVE CELLADHESION PROTEIN (Bacteroidesthetaiotaomicron) |
no annotation | 4 | ASN A 208SER A 171LEU A 172THR A 206 | None | 1.47A | 4an2A-4dguA:undetectable | 4an2A-4dguA:22.81 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4e2a | PUTATIVEACETYLTRANSFERASE (Streptococcusmutans) |
PF13673(Acetyltransf_10) | 4 | ASN A 78SER A 126LEU A 125THR A 84 | None | 1.28A | 4an2A-4e2aA:undetectable | 4an2A-4e2aA:19.93 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4eb0 | LCC (unculturedbacterium) |
PF12695(Abhydrolase_5) | 4 | ASN A 288SER A 258LEU A 274THR A 230 | None | 1.43A | 4an2A-4eb0A:undetectable | 4an2A-4eb0A:20.00 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4eud | SUCCINYL-COA:ACETATECOENZYME ATRANSFERASE (Acetobacteraceti) |
PF02550(AcetylCoA_hydro)PF13336(AcetylCoA_hyd_C) | 4 | ASN A 173SER A 318LEU A 319THR A 137 | None | 1.48A | 4an2A-4eudA:undetectable | 4an2A-4eudA:20.85 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4fgv | CHROMOSOME REGIONMAINTENANCE 1 (CRM1)OR EXPORTIN 1 (XPO1) (Chaetomiumthermophilum) |
PF03810(IBN_N)PF08389(Xpo1)PF08767(CRM1_C) | 4 | ASN A 194SER A 200LEU A 201THR A 229 | None | 1.14A | 4an2A-4fgvA:undetectable | 4an2A-4fgvA:15.10 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4gbf | PHIKZ131 (Pseudomonasvirus phiKZ) |
no annotation | 4 | ASN A 575SER A 505LEU A 516THR A 587 | None | 1.39A | 4an2A-4gbfA:undetectable | 4an2A-4gbfA:22.31 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4gnr | ABC TRANSPORTERSUBSTRATE-BINDINGPROTEIN-BRANCHEDCHAIN AMINO ACIDTRANSPORT (Streptococcuspneumoniae) |
PF13458(Peripla_BP_6) | 4 | ASN A 265SER A 91LEU A 53THR A 314 | None | 1.38A | 4an2A-4gnrA:undetectable | 4an2A-4gnrA:23.27 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4hum | PROTEIN B (Escherichiacoli) |
PF00041(fn3) | 4 | ASN B 88SER B 17LEU B 18THR B 39 | None | 1.45A | 4an2A-4humB:undetectable | 4an2A-4humB:14.98 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4jhp | X-LINKED RETINITISPIGMENTOSA GTPASEREGULATOR (Homo sapiens) |
PF00415(RCC1) | 4 | ASN C 107SER C 152LEU C 100THR C 137 | None | 1.47A | 4an2A-4jhpC:undetectable | 4an2A-4jhpC:20.94 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4k15 | LMO2686 PROTEIN (Listeriamonocytogenes) |
no annotation | 4 | ASN A 160SER A 127LEU A 130THR A 162 | None | 1.49A | 4an2A-4k15A:undetectable | 4an2A-4k15A:18.89 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4mu6 | KINECTIN 1 (KINESINRECEPTOR) (Legionellapneumophila) |
no annotation | 4 | ASN A 106SER A 175LEU A 176THR A 102 | None | 1.25A | 4an2A-4mu6A:undetectable | 4an2A-4mu6A:23.12 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4p1n | ATG1 TMIT (Kluyveromycesmarxianus) |
PF12063(DUF3543) | 4 | ASN A 570SER A 679LEU A 683THR A 697 | None | 1.20A | 4an2A-4p1nA:undetectable | 4an2A-4p1nA:21.71 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4qex | ANTIBODY HEAVY CHAIN (Mus musculus) |
PF07654(C1-set)PF07686(V-set) | 4 | ASN H 195SER H 160LEU H 158THR H 150 | None | 1.35A | 4an2A-4qexH:undetectable | 4an2A-4qexH:19.80 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4uf7 | GLYCOPROTEIN (Ghanaian bathenipavirus) |
PF00423(HN) | 4 | ASN A 224SER A 288LEU A 265THR A 226 | None | 1.44A | 4an2A-4uf7A:0.9 | 4an2A-4uf7A:22.32 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4whb | PHENYLUREA HYDROLASEB (Mycolicibacteriumbrisbanense) |
no annotation | 4 | ASN E 331SER E 254LEU E 260THR E 327 | None | 1.40A | 4an2A-4whbE:undetectable | 4an2A-4whbE:20.99 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4yfz | OUTER CAPSID PROTEINVP4 (Rotavirus A) |
no annotation | 4 | ASN A 176SER A 74LEU A 76THR A 105 | None | 1.39A | 4an2A-4yfzA:undetectable | 4an2A-4yfzA:22.45 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4zhj | MG-CHELATASE SUBUNITCHLH (Synechocystissp. PCC 6803) |
PF02514(CobN-Mg_chel)PF11965(DUF3479) | 4 | ASN A1161SER A1212LEU A1211THR A1201 | None | 1.39A | 4an2A-4zhjA:undetectable | 4an2A-4zhjA:13.49 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4zo6 | LIN1840 PROTEIN (Listeriainnocua) |
PF00933(Glyco_hydro_3)PF01915(Glyco_hydro_3_C)PF14310(Fn3-like) | 4 | ASN A 253SER A 321LEU A 324THR A 247 | None | 1.36A | 4an2A-4zo6A:undetectable | 4an2A-4zo6A:18.42 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 5a8q | PUTATIVE RETAININGB-GLYCOSIDASE (Saccharophagusdegradans) |
PF00150(Cellulase) | 4 | ASN A 72SER A 88LEU A 89THR A 328 | None | 1.06A | 4an2A-5a8qA:undetectable | 4an2A-5a8qA:19.14 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 5aa4 | MEMBRANE-BOUND LYTICMUREINTRANSGLYCOSYLASE F (Pseudomonasaeruginosa) |
PF00497(SBP_bac_3)PF01464(SLT) | 4 | ASN B 51SER B 159LEU B 156THR B 86 | None | 1.15A | 4an2A-5aa4B:undetectable | 4an2A-5aa4B:20.90 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 5b37 | TRYPTOPHANDEHYDROGENASE (Nostocpunctiforme) |
PF00208(ELFV_dehydrog)PF02812(ELFV_dehydrog_N) | 4 | ASN A 309SER A 147LEU A 148THR A 313 | None | 1.48A | 4an2A-5b37A:undetectable | 4an2A-5b37A:23.06 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 5c3l | NUCLEOPORIN NUP58NUP54 (Xenopus laevis) |
PF13874(Nup54)PF15967(Nucleoporin_FG2) | 4 | ASN A 392SER B 329LEU B 328THR A 396 | None | 1.36A | 4an2A-5c3lA:undetectable | 4an2A-5c3lA:23.22 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 5dv0 | SORTASE SRTA (Streptococcuspneumoniae) |
PF04203(Sortase) | 4 | ASN A 117SER A 155LEU A 153THR A 124 | None | 1.46A | 4an2A-5dv0A:undetectable | 4an2A-5dv0A:20.20 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 5evm | FUSION GLYCOPROTEINF0 (Nipahhenipavirus) |
PF00523(Fusion_gly) | 4 | ASN A 84SER A 208LEU A 207THR A 88 | None | 1.14A | 4an2A-5evmA:undetectable | 4an2A-5evmA:19.66 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 5ewp | ARO (ARMADILLOREPEATS ONLYPROTEIN) (Plasmodiumfalciparum) |
no annotation | 4 | ASN A 200SER A 266LEU A 254THR A 196 | None | 1.28A | 4an2A-5ewpA:undetectable | 4an2A-5ewpA:22.96 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 5fl7 | ATP SYNTHASE SUBUNITBETA (Yarrowialipolytica) |
PF00006(ATP-synt_ab)PF02874(ATP-synt_ab_N) | 4 | ASN D 404SER D 386LEU D 389THR D 408 | None | 1.36A | 4an2A-5fl7D:undetectable | 4an2A-5fl7D:19.77 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 5i51 | TRANSKETOLASE (Scheffersomycesstipitis) |
PF00456(Transketolase_N)PF02779(Transket_pyr)PF02780(Transketolase_C) | 4 | ASN A 441SER A 377LEU A 380THR A 483 | None | 1.24A | 4an2A-5i51A:undetectable | 4an2A-5i51A:18.72 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 5imt | INTERMEDILYSIN (Streptococcusintermedius) |
PF01289(Thiol_cytolysin)PF17440(Thiol_cytolys_C) | 4 | ASN A 287SER A 269LEU A 64THR A 290 | None | 1.34A | 4an2A-5imtA:undetectable | 4an2A-5imtA:21.37 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 5imw | INTERMEDILYSIN (Streptococcusintermedius) |
PF01289(Thiol_cytolysin)PF17440(Thiol_cytolys_C) | 4 | ASN A 287SER A 269LEU A 64THR A 290 | None | 1.44A | 4an2A-5imwA:undetectable | 4an2A-5imwA:20.93 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 5utk | ANGIOPOIETIN-1RECEPTOR (Homo sapiens) |
PF00041(fn3) | 4 | ASN A 560SER A 666LEU A 634THR A 562 | None | 1.43A | 4an2A-5utkA:undetectable | 4an2A-5utkA:22.32 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 5wdu | ENVELOPEGLYCOPROTEIN GP160 (Humanimmunodeficiencyvirus 1) |
no annotation | 4 | ASN G 295SER G 256LEU G 261THR G 297 | NAG G 634 (-1.9A)NoneNAG G 627 ( 4.8A)NAG G 641 (-3.4A) | 1.44A | 4an2A-5wduG:undetectable | 4an2A-5wduG:14.75 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 5wq8 | TYPE II SECRETIONSYSTEM PROTEIN D (Vibrio cholerae) |
PF00263(Secretin)PF03958(Secretin_N) | 4 | ASN A 354SER A 413LEU A 422THR A 568 | None | 1.31A | 4an2A-5wq8A:2.9 | 4an2A-5wq8A:19.11 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 5xog | RNA POLYMERASE IISUBUNIT B12.5RNA POLYMERASE IITHIRD LARGESTSUBUNIT B44, PART OFCENTRAL CORE (Komagataellaphaffii) |
PF01000(RNA_pol_A_bac)PF01193(RNA_pol_L)PF13656(RNA_pol_L_2) | 4 | ASN K 96SER C 31LEU K 45THR K 100 | None | 1.20A | 4an2A-5xogK:3.1 | 4an2A-5xogK:20.07 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 6ar3 | GSI-IIC RT (Geobacillusstearothermophilus) |
no annotation | 4 | ASN A 12SER A 196LEU A 195THR A 15 | None | 1.35A | 4an2A-6ar3A:1.9 | 4an2A-6ar3A:23.23 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 6bzg | SPORULATION-SPECIFICPROTEIN 16 (Saccharomycescerevisiae) |
no annotation | 4 | ASN A 83SER A 101LEU A 98THR A 85 | None | 1.47A | 4an2A-6bzgA:undetectable | 4an2A-6bzgA:17.10 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 6c01 | ECTONUCLEOTIDEPYROPHOSPHATASE/PHOSPHODIESTERASE FAMILYMEMBER 3 (Homo sapiens) |
no annotation | 4 | ASN A 594SER A 632LEU A 625THR A 596 | NAG A 925 (-1.9A)NoneNoneNAG A 925 (-4.2A) | 1.11A | 4an2A-6c01A:undetectable | 4an2A-6c01A:13.12 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 6cfw | MBH SUBUNITMONOVALENT CATION/H+ANTIPORTER SUBUNIT B (Pyrococcusfuriosus) |
no annotation | 4 | ASN F 122SER F 107LEU F 113THR E 61 | None | 1.49A | 4an2A-6cfwF:undetectable | 4an2A-6cfwF:18.78 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 6cfz | DAD1,DAD1DUO1 (Chaetomiumthermophilum) |
no annotation | 4 | ASN D 82SER F 48LEU F 49THR D 85 | None | 1.49A | 4an2A-6cfzD:undetectable | 4an2A-6cfzD:16.25 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 6cty | DIHYDROOROTASE (Yersinia pestis) |
no annotation | 4 | ASN A 45SER A 27LEU A 26THR A 111 | MLT A 403 (-3.6A)NoneNoneMLT A 403 (-3.2A) | 1.40A | 4an2A-6ctyA:undetectable | 4an2A-6ctyA:13.99 |