SIMILAR PATTERNS OF AMINO ACIDS FOR 4AN2_A_EUIA1382_2

List of similar pattern of amino acids derived from ASSAM search

Hit pattern: 3D amino acid arrangements similar to known drug binding site

Query pattern: Residues from known binding site for annotated drug that match the hit pattern


(Click link on the last column to view superposed patterns of amino acids in NGL viewer)
(Note that only 3-12 residue patterns can be used for ASSAM searches)
Filter list by:
Hit Macromolecule/
Organism
Pfam Res. Interface HETATM RMSD Dali Z-score Seq. Identity (%) View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1alq CP254 BETA-LACTAMASE

(Staphylococcus
aureus)
PF13354
(Beta-lactamase2)
4 ASN A 191
SER A 200
LEU A 199
THR A  51
None
1.47A 4an2A-1alqA:
0.0
4an2A-1alqA:
22.64
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1aun PR-5D

(Nicotiana
tabacum)
PF00314
(Thaumatin)
4 ASN A 106
SER A 137
LEU A 138
THR A  64
None
1.28A 4an2A-1aunA:
0.0
4an2A-1aunA:
18.94
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1axk GLUXYN-1

(Bacillus
subtilis)
PF00457
(Glyco_hydro_11)
PF00722
(Glyco_hydro_16)
4 ASN A 208
SER A 240
LEU A 222
THR A 206
None
1.42A 4an2A-1axkA:
undetectable
4an2A-1axkA:
19.76
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1dkp PHYTASE

(Escherichia
coli)
PF00328
(His_Phos_2)
4 ASN A 251
SER A 206
LEU A 207
THR A 327
None
None
None
HG  A 503 ( 3.7A)
1.41A 4an2A-1dkpA:
0.3
4an2A-1dkpA:
19.37
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1fep FERRIC ENTEROBACTIN
RECEPTOR


(Escherichia
coli)
PF00593
(TonB_dep_Rec)
PF07715
(Plug)
4 ASN A 534
SER A 590
LEU A 599
THR A 506
None
1.48A 4an2A-1fepA:
0.1
4an2A-1fepA:
17.24
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1fpq ISOLIQUIRITIGENIN
2'-O-METHYLTRANSFERA
SE


(Medicago sativa)
PF00891
(Methyltransf_2)
PF08100
(Dimerisation)
4 ASN A  42
SER A  94
LEU A  91
THR A 136
None
1.32A 4an2A-1fpqA:
0.7
4an2A-1fpqA:
21.03
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1fs2 SKP2

(Homo sapiens)
PF12937
(F-box-like)
4 ASN A 236
SER A 224
LEU A 225
THR A 262
None
1.36A 4an2A-1fs2A:
undetectable
4an2A-1fs2A:
21.36
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1hwn EBULIN

(Sambucus ebulus)
PF00161
(RIP)
4 ASN A  61
SER A 177
LEU A 178
THR A 142
None
1.46A 4an2A-1hwnA:
undetectable
4an2A-1hwnA:
21.34
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ikp EXOTOXIN A

(Pseudomonas
aeruginosa)
PF09009
(Exotox-A_cataly)
PF09101
(Exotox-A_bind)
PF09102
(Exotox-A_target)
4 ASN A 112
SER A  65
LEU A  64
THR A 273
None
NA  A 703 ( 4.5A)
None
None
1.33A 4an2A-1ikpA:
0.4
4an2A-1ikpA:
18.46
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1kqf FORMATE
DEHYDROGENASE,
NITRATE-INDUCIBLE,
MAJOR SUBUNIT


(Escherichia
coli)
PF00384
(Molybdopterin)
PF01568
(Molydop_binding)
PF04879
(Molybdop_Fe4S4)
4 ASN A 144
SER A 461
LEU A 187
THR A 550
None
1.31A 4an2A-1kqfA:
undetectable
4an2A-1kqfA:
14.98
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1mox EPIDERMAL GROWTH
FACTOR RECEPTOR


(Homo sapiens)
PF00757
(Furin-like)
PF01030
(Recep_L_domain)
4 ASN A  40
SER A  99
LEU A  98
THR A  10
None
1.30A 4an2A-1moxA:
undetectable
4an2A-1moxA:
21.87
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1p9m INTERLEUKIN-6
RECEPTOR BETA CHAIN


(Homo sapiens)
PF00041
(fn3)
PF06328
(Lep_receptor_Ig)
PF09240
(IL6Ra-bind)
4 ASN A 236
SER A 207
LEU A 206
THR A 255
None
1.20A 4an2A-1p9mA:
undetectable
4an2A-1p9mA:
21.32
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1r4n AMYLOID BETA
PRECURSOR
PROTEIN-BINDING
PROTEIN 1


(Homo sapiens)
PF00899
(ThiF)
4 ASN A  72
SER A 523
LEU A 158
THR A  39
None
1.48A 4an2A-1r4nA:
undetectable
4an2A-1r4nA:
21.43
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1umr CONVULXIN BETA

(Crotalus
durissus)
PF00059
(Lectin_C)
4 ASN C 306
SER C 310
LEU C 309
THR C 247
None
1.45A 4an2A-1umrC:
undetectable
4an2A-1umrC:
15.05
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1xp4 D-ALANYL-D-ALANINE
CARBOXYPEPTIDASE


(Streptococcus
pneumoniae)
PF00768
(Peptidase_S11)
PF07943
(PBP5_C)
4 ASN A 163
SER A 122
LEU A  90
THR A 243
None
1.22A 4an2A-1xp4A:
undetectable
4an2A-1xp4A:
20.73
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1yts YERSINIA PROTEIN
TYROSINE PHOSPHATASE


(Yersinia
enterocolitica)
PF00102
(Y_phosphatase)
4 ASN A 424
SER A 362
LEU A 457
THR A 254
None
1.49A 4an2A-1ytsA:
undetectable
4an2A-1ytsA:
22.59
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1yz4 DUAL SPECIFICITY
PHOSPHATASE-LIKE 15
ISOFORM A


(Homo sapiens)
PF00782
(DSPc)
4 ASN A  83
SER A  95
LEU A  14
THR A  32
None
SO4  A 211 ( 4.5A)
None
None
1.39A 4an2A-1yz4A:
undetectable
4an2A-1yz4A:
21.21
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2ass S-PHASE
KINASE-ASSOCIATED
PROTEIN 2


(Homo sapiens)
PF12937
(F-box-like)
4 ASN B2224
SER B2212
LEU B2213
THR B2250
None
1.28A 4an2A-2assB:
undetectable
4an2A-2assB:
21.95
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2dpn GLYCEROL KINASE

(Thermus
thermophilus)
PF00370
(FGGY_N)
PF02782
(FGGY_C)
4 ASN A 271
SER A 279
LEU A 283
THR A 296
None
1.49A 4an2A-2dpnA:
undetectable
4an2A-2dpnA:
20.08
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2e0i 432AA LONG
HYPOTHETICAL
DEOXYRIBODIPYRIMIDIN
E PHOTOLYASE


(Sulfurisphaera
tokodaii)
PF00875
(DNA_photolyase)
PF03441
(FAD_binding_7)
4 ASN A 145
SER A 133
LEU A 134
THR A 141
None
1.32A 4an2A-2e0iA:
undetectable
4an2A-2e0iA:
22.69
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2eae ALPHA-FUCOSIDASE

(Bifidobacterium
bifidum)
PF14498
(Glyco_hyd_65N_2)
4 ASN A 695
SER A 730
LEU A 685
THR A 785
None
1.41A 4an2A-2eaeA:
undetectable
4an2A-2eaeA:
15.46
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2eae ALPHA-FUCOSIDASE

(Bifidobacterium
bifidum)
PF14498
(Glyco_hyd_65N_2)
4 ASN A 755
SER A 162
LEU A 161
THR A  61
None
1.42A 4an2A-2eaeA:
undetectable
4an2A-2eaeA:
15.46
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2gtr CHROMODOMAIN Y-LIKE
PROTEIN


(Homo sapiens)
PF00378
(ECH_1)
4 ASN A  31
SER A 118
LEU A 115
THR A  22
None
1.46A 4an2A-2gtrA:
undetectable
4an2A-2gtrA:
22.39
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2hga CONSERVED PROTEIN
MTH1368


(Methanothermobacter
thermautotrophicus)
PF00595
(PDZ)
4 ASN A  76
SER A  63
LEU A  66
THR A  78
None
1.41A 4an2A-2hgaA:
undetectable
4an2A-2hgaA:
18.56
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2ivf ETHYLBENZENE
DEHYDROGENASE
ALPHA-SUBUNIT


(Aromatoleum
aromaticum)
PF00384
(Molybdopterin)
PF01568
(Molydop_binding)
4 ASN A 958
SER A 214
LEU A 543
THR A 224
None
None
None
GOL  A1980 ( 4.9A)
1.37A 4an2A-2ivfA:
undetectable
4an2A-2ivfA:
15.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2j5g ALR4455 PROTEIN

(Nostoc sp. PCC
7120)
PF00378
(ECH_1)
4 ASN D  14
SER D 112
LEU D  64
THR D  31
None
1.15A 4an2A-2j5gD:
undetectable
4an2A-2j5gD:
23.05
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2ka9 DISKS LARGE HOMOLOG
4


(Rattus
norvegicus)
PF00595
(PDZ)
4 ASN A 156
SER A 128
LEU A 153
THR A 175
None
1.32A 4an2A-2ka9A:
undetectable
4an2A-2ka9A:
24.44
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2o0y TRANSCRIPTIONAL
REGULATOR


(Rhodococcus sp.)
PF01614
(IclR)
PF09339
(HTH_IclR)
4 ASN A 115
SER A 252
LEU A 212
THR A 113
None
1.47A 4an2A-2o0yA:
undetectable
4an2A-2o0yA:
22.26
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2wiu HTH-TYPE
TRANSCRIPTIONAL
REGULATOR HIPB


(Escherichia
coli)
PF01381
(HTH_3)
4 ASN B  15
SER B  63
LEU B  64
THR B  11
None
1.44A 4an2A-2wiuB:
undetectable
4an2A-2wiuB:
15.59
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2wl7 DISKS LARGE HOMOLOG
2


(Mus musculus)
PF00595
(PDZ)
4 ASN A 149
SER A 161
LEU A 153
THR A 132
CL  A1193 (-4.3A)
None
None
None
1.25A 4an2A-2wl7A:
undetectable
4an2A-2wl7A:
21.96
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3a1z HEMOLYMPH JUVENILE
HORMONE BINDING
PROTEIN


(Bombyx mori)
PF06585
(JHBP)
4 ASN A  66
SER A 162
LEU A 115
THR A  68
None
0.96A 4an2A-3a1zA:
undetectable
4an2A-3a1zA:
21.24
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3c0r UBIQUITIN
THIOESTERASE OTU1


(Saccharomyces
cerevisiae)
PF02338
(OTU)
4 ASN A 255
SER A 225
LEU A 226
THR A 259
None
1.25A 4an2A-3c0rA:
undetectable
4an2A-3c0rA:
23.10
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3d3m EUKARYOTIC
TRANSLATION
INITIATION FACTOR 4
GAMMA 2


(Homo sapiens)
PF02020
(W2)
4 ASN A 770
SER A 759
LEU A 762
THR A 774
None
1.14A 4an2A-3d3mA:
undetectable
4an2A-3d3mA:
19.80
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3dwk PENICILLIN-BINDING
PROTEIN 2


(Staphylococcus
aureus)
PF00905
(Transpeptidase)
PF00912
(Transgly)
4 ASN A 418
SER A 454
LEU A 451
THR A 687
None
SO4  A  26 (-3.1A)
None
None
1.48A 4an2A-3dwkA:
undetectable
4an2A-3dwkA:
18.38
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3hs3 RIBOSE OPERON
REPRESSOR


(Lactobacillus
acidophilus)
PF13377
(Peripla_BP_3)
4 ASN A 235
SER A 182
LEU A 183
THR A 233
None
1.37A 4an2A-3hs3A:
undetectable
4an2A-3hs3A:
24.69
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3hur ALANINE RACEMASE

(Oenococcus oeni)
PF00842
(Ala_racemase_C)
PF01168
(Ala_racemase_N)
4 ASN A 204
SER A  59
LEU A  22
THR A 207
SO4  A 395 (-4.0A)
None
None
None
1.38A 4an2A-3hurA:
undetectable
4an2A-3hurA:
23.41
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ilv GLUTAMINE-DEPENDENT
NAD(+) SYNTHETASE


(Cytophaga
hutchinsonii)
PF00795
(CN_hydrolase)
PF02540
(NAD_synthase)
4 ASN A  12
SER A  82
LEU A  42
THR A  14
None
1.34A 4an2A-3ilvA:
undetectable
4an2A-3ilvA:
20.57
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3jcl SPIKE GLYCOPROTEIN

(Murine
coronavirus)
PF01601
(Corona_S2)
PF09408
(Spike_rec_bind)
PF16451
(Spike_NTD)
4 ASN A1048
SER A1026
LEU A1027
THR A1052
None
1.48A 4an2A-3jclA:
1.6
4an2A-3jclA:
13.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3l6a EUKARYOTIC
TRANSLATION
INITIATION FACTOR 4
GAMMA 2


(Homo sapiens)
PF02020
(W2)
PF02847
(MA3)
4 ASN A 233
SER A 222
LEU A 225
THR A 237
None
1.16A 4an2A-3l6aA:
undetectable
4an2A-3l6aA:
23.47
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3mkl HTH-TYPE
TRANSCRIPTIONAL
REGULATOR GADX


(Escherichia
coli)
PF12833
(HTH_18)
4 ASN A 142
SER A 171
LEU A 174
THR A 145
None
1.17A 4an2A-3mklA:
undetectable
4an2A-3mklA:
18.43
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3pnt IMMUNITY FACTOR FOR
SPN


(Streptococcus
pyogenes)
PF16718
(IFS)
4 ASN B  97
SER B 108
LEU B 109
THR B 160
None
1.33A 4an2A-3pntB:
undetectable
4an2A-3pntB:
21.19
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3qk8 ENOYL-COA HYDRATASE
ECHA15


(Mycobacterium
marinum)
PF00378
(ECH_1)
4 ASN A  22
SER A  67
LEU A  25
THR A 199
None
1.30A 4an2A-3qk8A:
undetectable
4an2A-3qk8A:
22.91
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3rks HYDROXYNITRILASE

(Manihot
esculenta)
PF00561
(Abhydrolase_1)
4 ASN A  52
SER A 115
LEU A 184
THR A 140
None
1.42A 4an2A-3rksA:
undetectable
4an2A-3rksA:
21.10
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3rpi LIGHT CHAIN FROM
HIGHLY POTENT
ANTI-HIV
NEUTRALIZING
ANTIBODY


(Homo sapiens)
no annotation 4 ASN L 126
SER L 191
LEU L 190
THR L 161
None
1.43A 4an2A-3rpiL:
undetectable
4an2A-3rpiL:
22.76
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3rpi LIGHT CHAIN FROM
HIGHLY POTENT
ANTI-HIV
NEUTRALIZING
ANTIBODY


(Homo sapiens)
no annotation 4 ASN L 127
SER L 191
LEU L 190
THR L 161
None
1.49A 4an2A-3rpiL:
undetectable
4an2A-3rpiL:
22.76
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ss7 D-SERINE DEHYDRATASE

(Escherichia
coli)
PF00291
(PALP)
4 ASN X 170
SER X 241
LEU X 244
THR X 424
PLP  X 502 (-3.8A)
None
None
PLP  X 502 (-3.0A)
1.36A 4an2A-3ss7X:
undetectable
4an2A-3ss7X:
21.30
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3sy8 ROCR

(Pseudomonas
aeruginosa)
PF00072
(Response_reg)
PF00563
(EAL)
4 ASN A 233
SER A 241
LEU A 244
THR A 267
MG  A 401 (-2.7A)
None
None
None
1.31A 4an2A-3sy8A:
undetectable
4an2A-3sy8A:
24.11
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3t8j PURINE NUCLEOSIDASE,
(IUNH-1)


(Sulfolobus
solfataricus)
PF01156
(IU_nuc_hydro)
4 ASN A 309
SER A  17
LEU A  20
THR A 208
None
1.49A 4an2A-3t8jA:
undetectable
4an2A-3t8jA:
21.41
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3tht ALKYLATED DNA REPAIR
PROTEIN ALKB HOMOLOG
8


(Homo sapiens)
PF00076
(RRM_1)
PF13532
(2OG-FeII_Oxy_2)
4 ASN A  49
SER A  93
LEU A  45
THR A 114
None
1.45A 4an2A-3thtA:
undetectable
4an2A-3thtA:
23.06
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3tql ARGININE-BINDING
PROTEIN


(Coxiella
burnetii)
PF00497
(SBP_bac_3)
4 ASN A 109
SER A  91
LEU A  92
THR A 111
ARG  A   1 (-3.6A)
None
None
None
1.32A 4an2A-3tqlA:
undetectable
4an2A-3tqlA:
21.52
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3twi VARIABLE LYMPHOCYTE
RECEPTOR B


(Petromyzon
marinus)
PF01462
(LRRNT)
PF13855
(LRR_8)
4 ASN D  34
SER D  42
LEU D  40
THR D  32
None
1.41A 4an2A-3twiD:
undetectable
4an2A-3twiD:
20.60
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3v98 ARACHIDONATE
5-LIPOXYGENASE


(Homo sapiens)
PF00305
(Lipoxygenase)
PF01477
(PLAT)
4 ASN A 407
SER A 608
LEU A 607
THR A 403
None
1.37A 4an2A-3v98A:
undetectable
4an2A-3v98A:
18.68
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3vzm ENDO-1,4-BETA-XYLANA
SE


(Bacillus
circulans)
PF00457
(Glyco_hydro_11)
4 ASN A  52
SER A  84
LEU A  66
THR A  50
None
1.40A 4an2A-3vzmA:
undetectable
4an2A-3vzmA:
17.55
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3w0s HYGROMYCIN-B
4-O-KINASE


(Escherichia
coli)
PF01636
(APH)
4 ASN A 203
SER A  69
LEU A  72
THR A  99
ANP  A 402 ( 4.6A)
None
None
None
1.40A 4an2A-3w0sA:
6.6
4an2A-3w0sA:
22.82
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3znj 5-CHLOROMUCONOLACTON
E DEHALOGENASE


(Rhodococcus
opacus)
PF02426
(MIase)
4 ASN 1  10
SER 1  26
LEU 1  23
THR 1   8
None
1.31A 4an2A-3znj1:
undetectable
4an2A-3znj1:
14.48
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3znj 5-CHLOROMUCONOLACTON
E DEHALOGENASE


(Rhodococcus
opacus)
PF02426
(MIase)
4 ASN 1  10
SER 1  26
LEU 1  23
THR 1  78
None
1.48A 4an2A-3znj1:
undetectable
4an2A-3znj1:
14.48
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4anj UNCONVENTIONAL
MYOSIN-VI, GREEN
FLUORESCENT PROTEIN


(Aequorea
victoria;
Sus scrofa)
PF00063
(Myosin_head)
PF01353
(GFP)
4 ASN A  76
SER A 687
LEU A 686
THR A  88
None
1.31A 4an2A-4anjA:
1.4
4an2A-4anjA:
14.49
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4arv PHYTASE

(Yersinia
kristensenii)
PF00328
(His_Phos_2)
4 ASN A 171
SER A 247
LEU A 165
THR A  34
None
1.19A 4an2A-4arvA:
undetectable
4an2A-4arvA:
22.53
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4buj ANTIVIRAL PROTEIN
SKI8


(Saccharomyces
cerevisiae)
PF00400
(WD40)
4 ASN C 222
SER C 195
LEU C 199
THR C 208
None
1.30A 4an2A-4bujC:
undetectable
4an2A-4bujC:
22.63
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4c23 L-FUCULOSE KINASE
FUCK


(Streptococcus
pneumoniae)
PF00370
(FGGY_N)
PF02782
(FGGY_C)
4 ASN A 124
SER A 110
LEU A 115
THR A 177
None
1.43A 4an2A-4c23A:
undetectable
4an2A-4c23A:
21.13
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4cvu BETA-MANNOSIDASE

(Trichoderma
harzianum)
PF00703
(Glyco_hydro_2)
4 ASN A 855
SER A 884
LEU A 885
THR A 658
None
1.49A 4an2A-4cvuA:
undetectable
4an2A-4cvuA:
16.51
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4dgu PUTATIVE CELL
ADHESION PROTEIN


(Bacteroides
thetaiotaomicron)
no annotation 4 ASN A 208
SER A 171
LEU A 172
THR A 206
None
1.47A 4an2A-4dguA:
undetectable
4an2A-4dguA:
22.81
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4e2a PUTATIVE
ACETYLTRANSFERASE


(Streptococcus
mutans)
PF13673
(Acetyltransf_10)
4 ASN A  78
SER A 126
LEU A 125
THR A  84
None
1.28A 4an2A-4e2aA:
undetectable
4an2A-4e2aA:
19.93
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4eb0 LCC

(uncultured
bacterium)
PF12695
(Abhydrolase_5)
4 ASN A 288
SER A 258
LEU A 274
THR A 230
None
1.43A 4an2A-4eb0A:
undetectable
4an2A-4eb0A:
20.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4eud SUCCINYL-COA:ACETATE
COENZYME A
TRANSFERASE


(Acetobacter
aceti)
PF02550
(AcetylCoA_hydro)
PF13336
(AcetylCoA_hyd_C)
4 ASN A 173
SER A 318
LEU A 319
THR A 137
None
1.48A 4an2A-4eudA:
undetectable
4an2A-4eudA:
20.85
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4fgv CHROMOSOME REGION
MAINTENANCE 1 (CRM1)
OR EXPORTIN 1 (XPO1)


(Chaetomium
thermophilum)
PF03810
(IBN_N)
PF08389
(Xpo1)
PF08767
(CRM1_C)
4 ASN A 194
SER A 200
LEU A 201
THR A 229
None
1.14A 4an2A-4fgvA:
undetectable
4an2A-4fgvA:
15.10
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4gbf PHIKZ131

(Pseudomonas
virus phiKZ)
no annotation 4 ASN A 575
SER A 505
LEU A 516
THR A 587
None
1.39A 4an2A-4gbfA:
undetectable
4an2A-4gbfA:
22.31
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4gnr ABC TRANSPORTER
SUBSTRATE-BINDING
PROTEIN-BRANCHED
CHAIN AMINO ACID
TRANSPORT


(Streptococcus
pneumoniae)
PF13458
(Peripla_BP_6)
4 ASN A 265
SER A  91
LEU A  53
THR A 314
None
1.38A 4an2A-4gnrA:
undetectable
4an2A-4gnrA:
23.27
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4hum PROTEIN B

(Escherichia
coli)
PF00041
(fn3)
4 ASN B  88
SER B  17
LEU B  18
THR B  39
None
1.45A 4an2A-4humB:
undetectable
4an2A-4humB:
14.98
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4jhp X-LINKED RETINITIS
PIGMENTOSA GTPASE
REGULATOR


(Homo sapiens)
PF00415
(RCC1)
4 ASN C 107
SER C 152
LEU C 100
THR C 137
None
1.47A 4an2A-4jhpC:
undetectable
4an2A-4jhpC:
20.94
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4k15 LMO2686 PROTEIN

(Listeria
monocytogenes)
no annotation 4 ASN A 160
SER A 127
LEU A 130
THR A 162
None
1.49A 4an2A-4k15A:
undetectable
4an2A-4k15A:
18.89
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4mu6 KINECTIN 1 (KINESIN
RECEPTOR)


(Legionella
pneumophila)
no annotation 4 ASN A 106
SER A 175
LEU A 176
THR A 102
None
1.25A 4an2A-4mu6A:
undetectable
4an2A-4mu6A:
23.12
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4p1n ATG1 TMIT

(Kluyveromyces
marxianus)
PF12063
(DUF3543)
4 ASN A 570
SER A 679
LEU A 683
THR A 697
None
1.20A 4an2A-4p1nA:
undetectable
4an2A-4p1nA:
21.71
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4qex ANTIBODY HEAVY CHAIN

(Mus musculus)
PF07654
(C1-set)
PF07686
(V-set)
4 ASN H 195
SER H 160
LEU H 158
THR H 150
None
1.35A 4an2A-4qexH:
undetectable
4an2A-4qexH:
19.80
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4uf7 GLYCOPROTEIN

(Ghanaian bat
henipavirus)
PF00423
(HN)
4 ASN A 224
SER A 288
LEU A 265
THR A 226
None
1.44A 4an2A-4uf7A:
0.9
4an2A-4uf7A:
22.32
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4whb PHENYLUREA HYDROLASE
B


(Mycolicibacterium
brisbanense)
no annotation 4 ASN E 331
SER E 254
LEU E 260
THR E 327
None
1.40A 4an2A-4whbE:
undetectable
4an2A-4whbE:
20.99
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4yfz OUTER CAPSID PROTEIN
VP4


(Rotavirus A)
no annotation 4 ASN A 176
SER A  74
LEU A  76
THR A 105
None
1.39A 4an2A-4yfzA:
undetectable
4an2A-4yfzA:
22.45
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4zhj MG-CHELATASE SUBUNIT
CHLH


(Synechocystis
sp. PCC 6803)
PF02514
(CobN-Mg_chel)
PF11965
(DUF3479)
4 ASN A1161
SER A1212
LEU A1211
THR A1201
None
1.39A 4an2A-4zhjA:
undetectable
4an2A-4zhjA:
13.49
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4zo6 LIN1840 PROTEIN

(Listeria
innocua)
PF00933
(Glyco_hydro_3)
PF01915
(Glyco_hydro_3_C)
PF14310
(Fn3-like)
4 ASN A 253
SER A 321
LEU A 324
THR A 247
None
1.36A 4an2A-4zo6A:
undetectable
4an2A-4zo6A:
18.42
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5a8q PUTATIVE RETAINING
B-GLYCOSIDASE


(Saccharophagus
degradans)
PF00150
(Cellulase)
4 ASN A  72
SER A  88
LEU A  89
THR A 328
None
1.06A 4an2A-5a8qA:
undetectable
4an2A-5a8qA:
19.14
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5aa4 MEMBRANE-BOUND LYTIC
MUREIN
TRANSGLYCOSYLASE F


(Pseudomonas
aeruginosa)
PF00497
(SBP_bac_3)
PF01464
(SLT)
4 ASN B  51
SER B 159
LEU B 156
THR B  86
None
1.15A 4an2A-5aa4B:
undetectable
4an2A-5aa4B:
20.90
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5b37 TRYPTOPHAN
DEHYDROGENASE


(Nostoc
punctiforme)
PF00208
(ELFV_dehydrog)
PF02812
(ELFV_dehydrog_N)
4 ASN A 309
SER A 147
LEU A 148
THR A 313
None
1.48A 4an2A-5b37A:
undetectable
4an2A-5b37A:
23.06
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5c3l NUCLEOPORIN NUP58
NUP54


(Xenopus laevis)
PF13874
(Nup54)
PF15967
(Nucleoporin_FG2)
4 ASN A 392
SER B 329
LEU B 328
THR A 396
None
1.36A 4an2A-5c3lA:
undetectable
4an2A-5c3lA:
23.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5dv0 SORTASE SRTA

(Streptococcus
pneumoniae)
PF04203
(Sortase)
4 ASN A 117
SER A 155
LEU A 153
THR A 124
None
1.46A 4an2A-5dv0A:
undetectable
4an2A-5dv0A:
20.20
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5evm FUSION GLYCOPROTEIN
F0


(Nipah
henipavirus)
PF00523
(Fusion_gly)
4 ASN A  84
SER A 208
LEU A 207
THR A  88
None
1.14A 4an2A-5evmA:
undetectable
4an2A-5evmA:
19.66
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ewp ARO (ARMADILLO
REPEATS ONLY
PROTEIN)


(Plasmodium
falciparum)
no annotation 4 ASN A 200
SER A 266
LEU A 254
THR A 196
None
1.28A 4an2A-5ewpA:
undetectable
4an2A-5ewpA:
22.96
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5fl7 ATP SYNTHASE SUBUNIT
BETA


(Yarrowia
lipolytica)
PF00006
(ATP-synt_ab)
PF02874
(ATP-synt_ab_N)
4 ASN D 404
SER D 386
LEU D 389
THR D 408
None
1.36A 4an2A-5fl7D:
undetectable
4an2A-5fl7D:
19.77
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5i51 TRANSKETOLASE

(Scheffersomyces
stipitis)
PF00456
(Transketolase_N)
PF02779
(Transket_pyr)
PF02780
(Transketolase_C)
4 ASN A 441
SER A 377
LEU A 380
THR A 483
None
1.24A 4an2A-5i51A:
undetectable
4an2A-5i51A:
18.72
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5imt INTERMEDILYSIN

(Streptococcus
intermedius)
PF01289
(Thiol_cytolysin)
PF17440
(Thiol_cytolys_C)
4 ASN A 287
SER A 269
LEU A  64
THR A 290
None
1.34A 4an2A-5imtA:
undetectable
4an2A-5imtA:
21.37
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5imw INTERMEDILYSIN

(Streptococcus
intermedius)
PF01289
(Thiol_cytolysin)
PF17440
(Thiol_cytolys_C)
4 ASN A 287
SER A 269
LEU A  64
THR A 290
None
1.44A 4an2A-5imwA:
undetectable
4an2A-5imwA:
20.93
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5utk ANGIOPOIETIN-1
RECEPTOR


(Homo sapiens)
PF00041
(fn3)
4 ASN A 560
SER A 666
LEU A 634
THR A 562
None
1.43A 4an2A-5utkA:
undetectable
4an2A-5utkA:
22.32
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5wdu ENVELOPE
GLYCOPROTEIN GP160


(Human
immunodeficiency
virus 1)
no annotation 4 ASN G 295
SER G 256
LEU G 261
THR G 297
NAG  G 634 (-1.9A)
None
NAG  G 627 ( 4.8A)
NAG  G 641 (-3.4A)
1.44A 4an2A-5wduG:
undetectable
4an2A-5wduG:
14.75
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5wq8 TYPE II SECRETION
SYSTEM PROTEIN D


(Vibrio cholerae)
PF00263
(Secretin)
PF03958
(Secretin_N)
4 ASN A 354
SER A 413
LEU A 422
THR A 568
None
1.31A 4an2A-5wq8A:
2.9
4an2A-5wq8A:
19.11
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5xog RNA POLYMERASE II
SUBUNIT B12.5
RNA POLYMERASE II
THIRD LARGEST
SUBUNIT B44, PART OF
CENTRAL CORE


(Komagataella
phaffii)
PF01000
(RNA_pol_A_bac)
PF01193
(RNA_pol_L)
PF13656
(RNA_pol_L_2)
4 ASN K  96
SER C  31
LEU K  45
THR K 100
None
1.20A 4an2A-5xogK:
3.1
4an2A-5xogK:
20.07
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6ar3 GSI-IIC RT

(Geobacillus
stearothermophilus)
no annotation 4 ASN A  12
SER A 196
LEU A 195
THR A  15
None
1.35A 4an2A-6ar3A:
1.9
4an2A-6ar3A:
23.23
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6bzg SPORULATION-SPECIFIC
PROTEIN 16


(Saccharomyces
cerevisiae)
no annotation 4 ASN A  83
SER A 101
LEU A  98
THR A  85
None
1.47A 4an2A-6bzgA:
undetectable
4an2A-6bzgA:
17.10
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6c01 ECTONUCLEOTIDE
PYROPHOSPHATASE/PHOS
PHODIESTERASE FAMILY
MEMBER 3


(Homo sapiens)
no annotation 4 ASN A 594
SER A 632
LEU A 625
THR A 596
NAG  A 925 (-1.9A)
None
None
NAG  A 925 (-4.2A)
1.11A 4an2A-6c01A:
undetectable
4an2A-6c01A:
13.12
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6cfw MBH SUBUNIT
MONOVALENT CATION/H+
ANTIPORTER SUBUNIT B


(Pyrococcus
furiosus)
no annotation 4 ASN F 122
SER F 107
LEU F 113
THR E  61
None
1.49A 4an2A-6cfwF:
undetectable
4an2A-6cfwF:
18.78
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6cfz DAD1,DAD1
DUO1


(Chaetomium
thermophilum)
no annotation 4 ASN D  82
SER F  48
LEU F  49
THR D  85
None
1.49A 4an2A-6cfzD:
undetectable
4an2A-6cfzD:
16.25
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6cty DIHYDROOROTASE

(Yersinia pestis)
no annotation 4 ASN A  45
SER A  27
LEU A  26
THR A 111
MLT  A 403 (-3.6A)
None
None
MLT  A 403 (-3.2A)
1.40A 4an2A-6ctyA:
undetectable
4an2A-6ctyA:
13.99